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Mammalian Phenotype (MP): abnormal innate immunity

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ 1:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
0:   abnormal innate immunity [MP:0002419] <5>(17|15) (18|9|5)
- 1:   abnormal macrophage physiology [MP:0002451] <10>(7|6) (8|4|2)
- 1:   abnormal complement pathway [MP:0002471] <6>(2|2) (2|1|1)
- 1:   abnormal acute phase protein level [MP:0010211] <3>(1|1) (1|1|0)
- 1:   abnormal neutrophil physiology [MP:0002463] <3>(1|1) (2|2|1)
- 1:   abnormal NK cell physiology [MP:0010766] <2>(7|5) (7|5|3)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
DEATH domain0.000002316Direct
Complement control module/SCR domain0.0002417Direct
Toll/Interleukin receptor TIR domain0.0003148Direct
4-helical cytokines0.001094Inherited
Transcription factor STAT-4 N-domain0.001881Inherited
STAT0.001881Inherited
SH2 domain0.003944Inherited
Flavoproteins0.008093Inherited
Kringle-like0.0177Inherited
Trypsin-like serine proteases0.02166Inherited
p53-like transcription factors0.08763Inherited
EGF/Laminin0.1796Inherited
MHC antigen-recognition domain0.214Inherited
Caspase-like0.247Inherited
L domain-like0.4214Inherited
SH3-domain0.6504Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Complement control module/SCR domain0.0001839Direct
Cytochrome p450 reductase N-terminal domain-like0.0004168Direct
Toll/Interleukin receptor TIR domain0.0005785Direct
STAT0.001379Inherited
Transcription factor STAT-4 N-domain0.001379Inherited
STAT DNA-binding domain0.001379Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.001494Inherited
NADPH-cytochrome p450 reductase-like0.001494Inherited
SH2 domain0.004031Inherited
Eukaryotic proteases0.01378Inherited
Kringle modules0.03268Inherited
Caspase catalytic domain0.1692Inherited
MHC antigen-recognition domain0.2009Inherited
SH3-domain0.6687Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
DEATH domain0.0000009633Direct
Complement control module/SCR domain0.0001227Direct
Toll/Interleukin receptor TIR domain0.0001626Direct
4-helical cytokines0.0006006Direct
Transcription factor STAT-4 N-domain0.001066Inherited
STAT0.001066Inherited
RNI-like0.001857Inherited
SH2 domain0.002323Inherited
Flavoproteins0.004989Inherited
Kringle-like0.01153Inherited
Trypsin-like serine proteases0.01431Inherited
p53-like transcription factors0.06532Inherited
EGF/Laminin0.1448Inherited
MHC antigen-recognition domain0.1762Inherited
Caspase-like0.207Inherited
L domain-like0.3745Inherited
SH3-domain0.6069Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.0003127Direct
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.0006607Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.001066Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.001066Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.001066Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.02799Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.05903Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.1211Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.001066Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.001066Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.00133Inherited
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.02347Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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