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Mammalian Phenotype (MP): abnormal adaptive immunity

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ 1:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
0:   abnormal adaptive immunity [MP:0002420] <8>(36|48) (38|33|21)
- 1:   abnormal leukocyte physiology [MP:0002442] <5>(34|48) (36|33|20)
- 1:   abnormal professional antigen presenting cell physiology [MP:0002452] <3>(25|32) (26|19|12)
- 1:   abnormal type I hypersensitivity reaction [MP:0002531] <2>(1|1) (1|0|0)
- 1:   abnormal type II hypersensitivity reaction [MP:0002532] <2>(0|0) (0|0|0)
- 1:   abnormal type III hypersensitivity reaction [MP:0002533] <2>(0|0) (0|0|0)
- 1:   abnormal type IV hypersensitivity reaction [MP:0002534] <2>(0|1) (0|0|0)
- 1:   abnormal class switch recombination [MP:0004816](1|1) (1|0|0)
- 1:   abnormal somatic hypermutation frequency [MP:0004815](1|0) (1|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Transcription factor STAT-4 N-domain0Direct
STAT0Direct
SH2 domain0.0001034Direct
Immunoglobulin0.0001096Direct
DEATH domain0.0003086Direct
SH3-domain0.0003565Direct
p53-like transcription factors0.004463Inherited
DBL homology domain (DH-domain)0.02159Inherited
Toll/Interleukin receptor TIR domain0.03895Inherited
TNF receptor-like0.04112Inherited
Caspase-like0.06549Inherited
MHC antigen-recognition domain0.06828Inherited
Flavoproteins0.08047Inherited
L30e-like0.1157Inherited
Interleukin 8-like chemokines0.1195Inherited
Bcl-2 inhibitors of programmed cell death0.1524Inherited
Cysteine-rich domain0.1681Inherited
Inhibitor of apoptosis (IAP) repeat0.2004Inherited
DNA/RNA polymerases0.2004Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.2629Inherited
4-helical cytokines0.305Inherited
E set domains0.3182Inherited
Integrin domains0.3428Inherited
WWE domain0.3453Inherited
Family A G protein-coupled receptor-like0.357Inherited
TNF-like0.3789Inherited
Integrin beta tail domain0.5004Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.5051Inherited
Integrin alpha N-terminal domain0.5305Inherited
C-type lectin-like0.6477Inherited
SMAD/FHA domain0.6601Inherited
Complement control module/SCR domain0.779Inherited
vWA-like0.8292Inherited
L domain-like1Inherited
EGF/Laminin1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
STAT0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cysteine rich domain0Direct
Proteasome subunits0Direct
Transcription factor STAT-4 N-domain0Direct
STAT DNA-binding domain0Direct
Rel/Dorsal transcription factors, DNA-binding domain0.000000762Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0000212Direct
SH2 domain0.00005107Direct
Pyrin domain, PYD0.0000847Direct
SH3-domain0.0001863Direct
Inhibitor of apoptosis (IAP) repeat0.0003754Direct
28-residue LRR0.0008558Direct
Pleckstrin-homology domain (PH domain)0.001256Inherited
Cytochrome p450 reductase N-terminal domain-like0.006349Inherited
C1 set domains (antibody constant domain-like)0.00697Inherited
V set domains (antibody variable domain-like)0.01013Inherited
DBL homology domain (DH-domain)0.01893Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.01955Inherited
NADPH-cytochrome p450 reductase-like0.01955Inherited
Caspase recruitment domain, CARD0.02564Inherited
Toll/Interleukin receptor TIR domain0.03538Inherited
TNF receptor-like0.05093Inherited
MHC antigen-recognition domain0.05093Inherited
PLC-like (P variant)0.05807Inherited
Caspase catalytic domain0.06647Inherited
DEATH domain, DD0.09349Inherited
Interleukin 8-like chemokines0.09349Inherited
ets domain0.09912Inherited
I set domains0.1057Inherited
Short-chain cytokines0.112Inherited
Bcl-2 inhibitors of programmed cell death0.1231Inherited
Rhodopsin-like0.192Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.2328Inherited
Interferon regulatory factor0.2941Inherited
Integrin domains0.3002Inherited
WWE domain0.3041Inherited
C-type lectin domain0.314Inherited
TNF-like0.3353Inherited
Integrin alpha N-terminal domain0.3998Inherited
FHA domain0.4393Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.4579Inherited
Integrin beta EGF-like domains0.4579Inherited
Integrin beta tail domain0.4579Inherited
Interleukin 17F, IL-17F0.561Inherited
Integrin A (or I) domain0.6827Inherited
Complement control module/SCR domain0.7445Inherited
EGF-type module0.9653Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Transcription factor STAT-4 N-domain0Direct
STAT0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
SH2 domain0.00005016Direct
Immunoglobulin0.00005324Direct
DEATH domain0.0001591Direct
SH3-domain0.0001854Direct
p53-like transcription factors0.002645Inherited
DBL homology domain (DH-domain)0.01427Inherited
Toll/Interleukin receptor TIR domain0.02697Inherited
TNF receptor-like0.02861Inherited
Caspase-like0.0476Inherited
MHC antigen-recognition domain0.04984Inherited
Flavoproteins0.05942Inherited
L30e-like0.08898Inherited
Interleukin 8-like chemokines0.09215Inherited
Bcl-2 inhibitors of programmed cell death0.1208Inherited
Cysteine-rich domain0.1345Inherited
RNI-like0.1406Inherited
DNA/RNA polymerases0.1637Inherited
Inhibitor of apoptosis (IAP) repeat0.1637Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.2217Inherited
4-helical cytokines0.2616Inherited
E set domains0.2741Inherited
Transducin (alpha subunit), insertion domain0.2908Inherited
Integrin domains0.2975Inherited
WWE domain0.3Inherited
Family A G protein-coupled receptor-like0.3115Inherited
TNF-like0.3328Inherited
Integrin beta tail domain0.4528Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.4575Inherited
Integrin alpha N-terminal domain0.4834Inherited
C-type lectin-like0.6042Inherited
SMAD/FHA domain0.6173Inherited
Complement control module/SCR domain0.7427Inherited
vWA-like0.7965Inherited
L domain-like0.9898Inherited
EGF/Laminin0.9934Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0Direct
    50370,57440
  • 50370 - Ricin B-like lectins
  • 57440 - Kringle-like
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    57440,56436
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    48366,47473
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0000004877Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0003015Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0003425Direct
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.00401Inherited
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.00546Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.01615Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.02112Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.02508Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.02861Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.03518Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.1101Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1208Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.1208Inherited
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.1637Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.1637Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.1637Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.2217Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.2217Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.2681Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.3Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.3962Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.3962Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.4528Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.4528Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.6362Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    50370,57440,56436
  • 50370 - Ricin B-like lectins
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    57440,56436,56436
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    48366,47473,57889
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 57889 - Cysteine-rich domain
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    57850,49599,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 49599 - TRAF domain-like
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.00546Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.00546Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.02508Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.02966Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.2217Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.2217Inherited
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.3Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.3Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.3962Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.4528Inherited
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.4733Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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