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Mammalian Phenotype (MP): abnormal blood cell morphology/development

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ 1:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(58|86) (66|47|21)
0:   abnormal blood cell morphology/development [MP:0002429] <3>(26|35) (28|24|9)
- 1:   anemia [MP:0001577] <4>(1|1) (1|0|0)
- 1:   abnormal hemopoiesis [MP:0013693] <2>(25|34) (27|24|9)
- 1:   impaired hematopoiesis [MP:0001606](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
PsbU/PolX domain-like0Direct
Transcription factor STAT-4 N-domain0Direct
STAT0Direct
SPOC domain-like0Direct
p53-like transcription factors0.000000009948Direct
SH2 domain0.00000001077Direct
DNA polymerase beta, N-terminal domain-like0.000722Direct
Cyclin-like0.002626Inherited
Protein kinase-like (PK-like)0.003008Inherited
AraD/HMP-PK domain-like0.003622Inherited
BRCT domain0.00451Inherited
E2F-DP heterodimerization region0.006432Inherited
SMAD/FHA domain0.007918Inherited
Bcl-2 inhibitors of programmed cell death0.02855Inherited
TNF receptor-like0.05659Inherited
Cysteine-rich domain0.06296Inherited
4-helical cytokines0.06705Inherited
Nucleotidyltransferase0.09524Inherited
Notch domain0.09955Inherited
DEATH domain0.1105Inherited
DNA/RNA polymerases0.2346Inherited
SET domain0.2351Inherited
SH3-domain0.2779Inherited
DBL homology domain (DH-domain)0.4693Inherited
Ankyrin repeat0.5695Inherited
Calponin-homology domain, CH-domain0.7831Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
STAT0Direct
Rel/Dorsal transcription factors, DNA-binding domain0Direct
RUNT domain0Direct
DNA polymerase beta-like, second domain0Direct
DNA polymerase beta-like0Direct
Transcription factor STAT-4 N-domain0Direct
STAT DNA-binding domain0Direct
SH2 domain0.0000000157Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.00000006461Direct
DNA polymerase beta, N-terminal domain-like0.0004942Direct
ets domain0.001863Inherited
E2F dimerization segment0.001952Inherited
AraD-like aldolase/epimerase0.002587Inherited
Cyclin0.002754Inherited
Short-chain cytokines0.00359Inherited
Cell cycle transcription factor e2f-dp0.01637Inherited
Bcl-2 inhibitors of programmed cell death0.02291Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.03134Inherited
Pointed domain0.04416Inherited
DEATH domain, DD0.0456Inherited
Myb/SANT domain0.05318Inherited
PLC-like (P variant)0.05444Inherited
TNF receptor-like0.07056Inherited
Notch domain0.08419Inherited
FHA domain0.1236Inherited
Pleckstrin-homology domain (PH domain)0.1257Inherited
V set domains (antibody variable domain-like)0.1487Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.1606Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.1623Inherited
DNA polymerase I0.1989Inherited
SH3-domain0.2932Inherited
MATH domain0.3269Inherited
DBL homology domain (DH-domain)0.4614Inherited
Ankyrin repeat0.5808Inherited
Calponin-homology domain, CH-domain0.7809Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SPOC domain-like0Direct
Transcription factor STAT-4 N-domain0Direct
STAT0Direct
PsbU/PolX domain-like0Direct
p53-like transcription factors0.000000003762Direct
SH2 domain0.00000000408Direct
DNA polymerase beta, N-terminal domain-like0.000387Direct
Cyclin-like0.001511Inherited
Protein kinase-like (PK-like)0.001745Inherited
AraD/HMP-PK domain-like0.002125Inherited
BRCT domain0.002677Inherited
E2F-DP heterodimerization region0.003919Inherited
SMAD/FHA domain0.004872Inherited
beta-beta-alpha zinc fingers0.01588Inherited
Bcl-2 inhibitors of programmed cell death0.01932Inherited
TNF receptor-like0.04048Inherited
Cysteine-rich domain0.0456Inherited
4-helical cytokines0.04882Inherited
Nucleotidyltransferase0.07152Inherited
Notch domain0.0751Inherited
DEATH domain0.08451Inherited
DNA/RNA polymerases0.1954Inherited
SET domain0.1959Inherited
SH3-domain0.236Inherited
DBL homology domain (DH-domain)0.4216Inherited
Acyl-CoA N-acyltransferases (Nat)0.5214Inherited
Ankyrin repeat0.5231Inherited
Calponin-homology domain, CH-domain0.7471Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.00005946Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.00006501Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.00008578Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.0004783Direct
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.0008514Direct
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0.002125Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.002125Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.003919Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.00821Inherited
    56112,56112
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.01932Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.03836Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.04069Inherited
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.04192Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.06059Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.08411Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.4216Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.002125Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.00242Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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