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Mammalian Phenotype (MP): abnormal leukocyte physiology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + + 3:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + 2:   abnormal hematopoietic system physiology [MP:0001545] <5>(39|53) (40|38|21)
+ + 2:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
+ 1:   abnormal cell-mediated immunity [MP:0002421] <3>(35|48) (37|33|21)
+ 1:   abnormal adaptive immunity [MP:0002420] <8>(36|48) (38|33|21)
+ 1:   abnormal blood cell physiology [MP:0012382] <3>(38|53) (39|38|21)
+ 1:   abnormal immune cell physiology [MP:0001819] <3>(35|48) (37|33|21)
0:   abnormal leukocyte physiology [MP:0002442] <5>(34|48) (36|33|20)
- 1:   abnormal macrophage physiology [MP:0002451] <10>(7|6) (8|4|2)
- 1:   abnormal leukocyte migration [MP:0003156] <7>(8|9) (8|5|3)
- 1:   abnormal granulocyte physiology [MP:0002462] <6>(3|3) (3|2|1)
- 1:   abnormal lymphocyte physiology [MP:0003945] <4>(21|31) (23|22|13)
- 1:   leukostasis [MP:0008541](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Transcription factor STAT-4 N-domain0Direct
STAT0Direct
TNF receptor-like0.00000004638Direct
p53-like transcription factors0.0000004999Direct
MHC antigen-recognition domain0.000002726Direct
4-helical cytokines0.00001404Direct
Caspase-like0.00002708Direct
Interleukin 8-like chemokines0.0001244Direct
Cysteine-rich domain0.000418Direct
Bcl-2 inhibitors of programmed cell death0.001494Inherited
Inhibitor of apoptosis (IAP) repeat0.001931Inherited
Integrin beta tail domain0.01562Inherited
DBL homology domain (DH-domain)0.01584Inherited
DEATH domain0.04298Inherited
E set domains0.05648Inherited
SH2 domain0.07146Inherited
Flavoproteins0.0727Inherited
WWE domain0.0727Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.09052Inherited
L30e-like0.1056Inherited
SMAD/FHA domain0.1407Inherited
SH3-domain0.1456Inherited
Toll/Interleukin receptor TIR domain0.2509Inherited
vWA-like0.3911Inherited
C-type lectin-like0.44Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.5904Inherited
TNF-like0.5985Inherited
L domain-like0.6652Inherited
Integrin domains0.7203Inherited
EGF/Laminin0.7652Inherited
Integrin alpha N-terminal domain0.8156Inherited
Family A G protein-coupled receptor-like0.9586Inherited
Complement control module/SCR domain0.9657Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
STAT0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cysteine rich domain0Direct
Proteasome subunits0Direct
Transcription factor STAT-4 N-domain0Direct
STAT DNA-binding domain0Direct
C1 set domains (antibody constant domain-like)0.00000003346Direct
TNF receptor-like0.00000004088Direct
Rel/Dorsal transcription factors, DNA-binding domain0.000000518Direct
MHC antigen-recognition domain0.000001904Direct
Short-chain cytokines0.000004123Direct
Caspase recruitment domain, CARD0.00001057Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.00001438Direct
Pyrin domain, PYD0.0000657Direct
Caspase catalytic domain0.00007324Direct
Interleukin 8-like chemokines0.00009193Direct
Inhibitor of apoptosis (IAP) repeat0.0003037Direct
28-residue LRR0.0006317Direct
Bcl-2 inhibitors of programmed cell death0.001046Inherited
Interferon regulatory factor0.001046Inherited
Cytochrome p450 reductase N-terminal domain-like0.005574Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.01181Inherited
Integrin beta tail domain0.01181Inherited
DBL homology domain (DH-domain)0.01364Inherited
Interleukin 17F, IL-17F0.01733Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.01733Inherited
NADPH-cytochrome p450 reductase-like0.01733Inherited
Integrin beta EGF-like domains0.02221Inherited
WWE domain0.03536Inherited
SH2 domain0.0461Inherited
ets domain0.08425Inherited
SH3-domain0.1028Inherited
Toll/Interleukin receptor TIR domain0.2194Inherited
V set domains (antibody variable domain-like)0.2249Inherited
I set domains0.2249Inherited
DEATH domain, DD0.2829Inherited
FHA domain0.4082Inherited
C-type lectin domain0.4126Inherited
Integrin A (or I) domain0.433Inherited
Pleckstrin-homology domain (PH domain)0.4338Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.5132Inherited
TNF-like0.5386Inherited
PLC-like (P variant)0.5386Inherited
Integrin domains0.6688Inherited
Integrin alpha N-terminal domain0.808Inherited
EGF-type module0.8094Inherited
Rhodopsin-like0.9247Inherited
Complement control module/SCR domain0.9463Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Transcription factor STAT-4 N-domain0Direct
STAT0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
TNF receptor-like0.00000001789Direct
p53-like transcription factors0.0000002012Direct
MHC antigen-recognition domain0.000001143Direct
4-helical cytokines0.00000621Direct
Caspase-like0.0000124Direct
Interleukin 8-like chemokines0.00006122Direct
Cysteine-rich domain0.0002192Direct
Bcl-2 inhibitors of programmed cell death0.0008363Direct
Inhibitor of apoptosis (IAP) repeat0.001095Inherited
Integrin beta tail domain0.01006Inherited
DBL homology domain (DH-domain)0.01023Inherited
RNI-like0.01799Inherited
DEATH domain0.03002Inherited
E set domains0.04039Inherited
SH2 domain0.05237Inherited
WWE domain0.05338Inherited
Flavoproteins0.05338Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.06765Inherited
L30e-like0.08023Inherited
SMAD/FHA domain0.1104Inherited
SH3-domain0.1148Inherited
Toll/Interleukin receptor TIR domain0.2106Inherited
vWA-like0.3447Inherited
C-type lectin-like0.3925Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.5443Inherited
TNF-like0.5531Inherited
L domain-like0.6227Inherited
Integrin domains0.6807Inherited
EGF/Laminin0.7276Inherited
Integrin alpha N-terminal domain0.7818Inherited
Family A G protein-coupled receptor-like0.9382Inherited
Complement control module/SCR domain0.9462Inherited
Transducin (alpha subunit), insertion domain0.9844Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0Direct
    50370,57440
  • 50370 - Ricin B-like lectins
  • 57440 - Kringle-like
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    57440,56436
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    48366,47473
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0000003295Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0000005396Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.000005384Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.000006903Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.000008096Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.0002433Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0002433Direct
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.0002433Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0002702Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.0008363Direct
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.00478Inherited
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.00641Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.01006Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.01006Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.01513Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.01551Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.03141Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.283Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.5531Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.667Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.667Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.8152Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.8152Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.9739Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.9844Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    50370,57440,56436
  • 50370 - Ricin B-like lectins
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    57440,56436,56436
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    48366,47473,57889
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 57889 - Cysteine-rich domain
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.00008921Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.001107Inherited
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.00478Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.00478Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.01006Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.01513Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.02497Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.667Inherited
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.7244Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.8152Inherited
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.8488Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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