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Mammalian Phenotype (MP): abnormal macrophage physiology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   abnormal hematopoietic system physiology [MP:0001545] <5>(39|53) (40|38|21)
+ + + 3:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + 2:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
+ + 2:   abnormal cell-mediated immunity [MP:0002421] <3>(35|48) (37|33|21)
+ + 2:   abnormal adaptive immunity [MP:0002420] <8>(36|48) (38|33|21)
+ + 2:   abnormal blood cell physiology [MP:0012382] <3>(38|53) (39|38|21)
+ + 2:   abnormal immune cell physiology [MP:0001819] <3>(35|48) (37|33|21)
+ 1:   abnormal leukocyte physiology [MP:0002442] <5>(34|48) (36|33|20)
+ 1:   abnormal professional antigen presenting cell physiology [MP:0002452] <3>(25|32) (26|19|12)
+ 1:   abnormal innate immunity [MP:0002419] <5>(17|15) (18|9|5)
0:   abnormal macrophage physiology [MP:0002451] <10>(7|6) (8|4|2)
- 1:   abnormal macrophage apoptosis [MP:0011073] <2>(2|1) (2|1|0)
- 1:   abnormal macrophage chemotaxis [MP:0010760] <2>(1|0) (1|0|0)
- 1:   abnormal macrophage cytokine production [MP:0011072] <2>(2|1) (2|0|0)
- 1:   abnormal macrophage nitric oxide production [MP:0011074] <2>(1|0) (1|0|0)
- 1:   abnormal macrophage proliferation [MP:0011985] <2>(0|0) (0|0|0)
- 1:   abnormal microglial cell physiology [MP:0003691] <2>(0|0) (0|0|0)
- 1:   abnormal macrophage antigen presentation [MP:0002454] <1>(0|0) (0|0|0)
- 1:   abnormal macrophage activation involved in immune response [MP:0011075](0|0) (0|0|0)
- 1:   abnormal osteoclast physiology [MP:0001541](2|4) (2|0|0)
- 1:   impaired macrophage phagocytosis [MP:0001798](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
DEATH domain0.00007865Direct
Toll/Interleukin receptor TIR domain0.0002582Direct
Flavoproteins0.002757Inherited
L domain-like0.03863Inherited
EGF/Laminin0.1024Inherited
Caspase-like0.2155Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0.000117Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0.0004461Direct
NADPH-cytochrome p450 reductase-like0.0004461Direct
Toll/Interleukin receptor TIR domain0.0004623Direct
Caspase catalytic domain0.1349Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
DEATH domain0.00003761Direct
Toll/Interleukin receptor TIR domain0.000132Direct
RNI-like0.0006617Direct
Flavoproteins0.00159Inherited
L domain-like0.02674Inherited
EGF/Laminin0.07751Inherited
Caspase-like0.1776Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.0000874Direct
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.0001901Direct
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.07666Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.0003398Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)