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Mammalian Phenotype (MP): abnormal neuron morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   nervous system phenotype [MP:0003631] <2>(98|127) (112|79|50)
+ 1:   abnormal nervous system morphology [MP:0003632] <17>(76|104) (91|64|47)
0:   abnormal neuron morphology [MP:0002882] <29>(36|59) (40|26|19)
- 1:   abnormal sensory neuron morphology [MP:0000965] <16>(16|28) (19|14|9)
- 1:   abnormal neuron differentiation [MP:0009937] <8>(8|11) (8|2|1)
- 1:   ectopic neuron [MP:0011723] <8>(4|5) (5|2|2)
- 1:   neuron degeneration [MP:0003224] <8>(3|3) (3|3|1)
- 1:   abnormal synapse morphology [MP:0009538] <7>(3|6) (3|2|2)
- 1:   abnormal Purkinje cell morphology [MP:0000877] <5>(0|1) (1|0|0)
- 1:   abnormal neuroendocrine cell morphology [MP:0010913] <5>(0|1) (1|0|0)
- 1:   abnormal cerebral cortex pyramidal cell morphology [MP:0009969] <4>(0|0) (0|0|0)
- 1:   abnormal dopaminergic neuron morphology [MP:0003243] <4>(0|0) (0|0|0)
- 1:   abnormal hippocampus neuron morphology [MP:0009939] <4>(2|2) (2|2|1)
- 1:   abnormal motor neuron morphology [MP:0000937] <4>(1|1) (1|0|0)
- 1:   abnormal Cajal-Retzius cell morphology [MP:0008030] <3>(1|1) (1|0|0)
- 1:   abnormal neuron number [MP:0008946] <3>(8|16) (9|9|8)
- 1:   abnormal enteric neuron morphology [MP:0001046] <2>(0|1) (0|0|0)
- 1:   abnormal neurite morphology [MP:0008415] <2>(4|9) (4|3|1)
- 1:   abnormal GABAergic neuron morphology [MP:0003245] <1>(1|1) (1|0|0)
- 1:   abnormal cholinergic neuron morphology [MP:0001038] <1>(0|0) (0|0|0)
- 1:   abnormal glutaminergic neuron morphology [MP:0003247] <1>(0|0) (0|0|0)
- 1:   abnormal adrenergic neuron morphology [MP:0001026](0|0) (0|0|0)
- 1:   abnormal glycinergic neuron morphology [MP:0010385](0|0) (0|0|0)
- 1:   abnormal medium spiny neuron morphology [MP:0008462](0|0) (0|0|0)
- 1:   abnormal neuron specification [MP:0002948](0|0) (1|0|0)
- 1:   abnormal peptidergic neuron morphology [MP:0001032](0|0) (0|0|0)
- 1:   abnormal serotonergic neuron morphology [MP:0003877](0|1) (1|0|0)
- 1:   abnormal thalamus neuron morphology [MP:0010369](0|0) (0|0|0)
- 1:   chromatolysis [MP:0002883](0|0) (0|0|0)
- 1:   neuron hypertrophy [MP:0005603](0|0) (0|0|0)
- 1:   neuronal cytoplasmic inclusions [MP:0011975](0|0) (0|0|0)
- 1:   neuronal intranuclear inclusions [MP:0004191](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Composite domain of metallo-dependent hydrolases0Direct
Lamin A/C globular tail domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
Tubby C-terminal domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Plexin repeat0.0009752Direct
Sema domain0.003084Inherited
Proton glutamate symport protein0.009331Inherited
Spectrin repeat0.01941Inherited
GTPase activation domain, GAP0.02935Inherited
EGF/Laminin0.03681Inherited
Nicotinic receptor ligand binding domain-like0.05745Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.05745Inherited
HLH, helix-loop-helix DNA-binding domain0.1185Inherited
Fibronectin type III0.1196Inherited
Clc chloride channel0.1859Inherited
Orange domain-like0.1859Inherited
Cyclin-like0.187Inherited
SAM/Pointed domain0.2377Inherited
GAF domain-like0.2614Inherited
Cap-Gly domain0.2614Inherited
Galactose-binding domain-like0.2909Inherited
Metallo-dependent hydrolases0.2929Inherited
lambda repressor-like DNA-binding domains0.2972Inherited
Homeodomain-like0.339Inherited
SNARE fusion complex0.3806Inherited
CBS-domain pair0.3806Inherited
HD-domain/PDEase-like0.3954Inherited
BAR/IMD domain-like0.4251Inherited
Notch domain0.4888Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.5943Inherited
Family A G protein-coupled receptor-like0.7322Inherited
HMG-box0.7808Inherited
E2F-DP heterodimerization region0.803Inherited
RNA-binding domain, RBD0.8153Inherited
alpha/beta-Hydrolases1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
Other IPT/TIG domains0Direct
Hydantoinase (dihydropyrimidinase), catalytic domain0Direct
Lamin A/C globular tail domain0Direct
Synapsin domain0Direct
Transcriptional factor tubby, C-terminal domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
Synapsin C-terminal domain0Direct
Oligoxyloglucan reducing end-specific cellobiohydrolase0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Neurotrophin0Direct
Hydantoinase (dihydropyrimidinase)0Direct
Ephrin ectodomain0.0001039Direct
Plexin repeat0.0007324Direct
DEP domain0.001173Inherited
L domain0.00192Inherited
Sema domain0.002369Inherited
Laminin-type module0.004919Inherited
Proton glutamate symport protein0.007085Inherited
Spectrin repeat0.01056Inherited
SAM (sterile alpha motif) domain0.02323Inherited
I set domains0.03878Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.04931Inherited
Nicotinic receptor ligand binding domain-like0.04931Inherited
Ephrin receptor ligand binding domain0.0528Inherited
EGF-type module0.08279Inherited
Adenylyl and guanylyl cyclase catalytic domain0.111Inherited
Extracellular domain of cell surface receptors0.1124Inherited
HLH, helix-loop-helix DNA-binding domain0.1139Inherited
Fibronectin type III0.1176Inherited
POU-specific domain0.1497Inherited
Clc chloride channel0.1626Inherited
Enabled/VASP homology 1 domain (EVH1 domain)0.1626Inherited
Hairy Orange domain0.1626Inherited
Cyclin0.2017Inherited
Calmodulin-like0.2307Inherited
GAF domain0.234Inherited
Cap-Gly domain0.234Inherited
p120GAP domain-like0.234Inherited
BAR domain0.2678Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.2685Inherited
PLC-like (P variant)0.2954Inherited
Homeodomain0.2957Inherited
PDEase0.3075Inherited
cAMP-binding domain0.3516Inherited
CBS-domain pair0.3551Inherited
SNARE fusion complex0.3551Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.4619Inherited
DIX domain0.4619Inherited
Acetylcholinesterase-like0.4619Inherited
Notch domain0.4619Inherited
Transforming growth factor (TGF)-beta0.5188Inherited
Canonical RBD0.5571Inherited
Rhodopsin-like0.6482Inherited
E2F dimerization segment0.6498Inherited
HMG-box0.7686Inherited
Cell cycle transcription factor e2f-dp0.7865Inherited
Synaptotagmin-like (S variant)0.9246Inherited
Forkhead DNA-binding domain0.9698Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Tubby C-terminal domain-like0Direct
Composite domain of metallo-dependent hydrolases0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Lamin A/C globular tail domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
Plexin repeat0.000531Direct
Sema domain0.001791Inherited
Proton glutamate symport protein0.00581Inherited
Spectrin repeat0.01273Inherited
GTPase activation domain, GAP0.01995Inherited
EGF/Laminin0.0254Inherited
L domain-like0.03766Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.04122Inherited
Nicotinic receptor ligand binding domain-like0.04122Inherited
HLH, helix-loop-helix DNA-binding domain0.09138Inherited
Nucleotide cyclase0.09212Inherited
Fibronectin type III0.09231Inherited
Clc chloride channel0.1506Inherited
Orange domain-like0.1506Inherited
Cyclin-like0.1515Inherited
SAM/Pointed domain0.1984Inherited
GAF domain-like0.2203Inherited
Cap-Gly domain0.2203Inherited
Galactose-binding domain-like0.2482Inherited
Metallo-dependent hydrolases0.2501Inherited
lambda repressor-like DNA-binding domains0.2541Inherited
Homeodomain-like0.294Inherited
CBS-domain pair0.3345Inherited
SNARE fusion complex0.3345Inherited
HD-domain/PDEase-like0.349Inherited
TPR-like0.3527Inherited
BAR/IMD domain-like0.3785Inherited
Notch domain0.4412Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.5486Inherited
Family A G protein-coupled receptor-like0.6933Inherited
HMG-box0.7447Inherited
E2F-DP heterodimerization region0.7684Inherited
RNA-binding domain, RBD0.7815Inherited
"Winged helix" DNA-binding domain0.8411Inherited
alpha/beta-Hydrolases0.9943Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
46966,51045
  • 46966 - Spectrin repeat
  • 51045 - WW domain
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    50044,50156
  • 50044 - SH3-domain
  • 50156 - PDZ domain-like
  • 0Direct
    51045,47473
  • 51045 - WW domain
  • 47473 - EF-hand
  • 0Direct
    51556,51338
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0Direct
    51338,51556
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 0Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.001453Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.001453Inherited
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.001791Inherited
    56112,55073
  • 56112 - Protein kinase-like (PK-like)
  • 55073 - Nucleotide cyclase
  • 0.01244Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.01451Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.01768Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.04122Inherited
    56112,47769
  • 56112 - Protein kinase-like (PK-like)
  • 47769 - SAM/Pointed domain
  • 0.04689Inherited
    81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.09898Inherited
    47473,57850
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.1506Inherited
    57196,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.1506Inherited
    47459,158457
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 158457 - Orange domain-like
  • 0.1506Inherited
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0.1983Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1983Inherited
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.2203Inherited
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.2203Inherited
    57184,49265
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0.2203Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.4412Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.6991Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.7684Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    51045,47473,47473
  • 51045 - WW domain
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0Direct
    51338,51556,51338
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    52058,48726,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0Direct
    46966,51045,47473
  • 46966 - Spectrin repeat
  • 51045 - WW domain
  • 47473 - EF-hand
  • 0Direct
    75399,75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    46966,46966,51045
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 51045 - WW domain
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.001453Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.00257Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.002672Inherited
    49899,57196,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.06944Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.07114Inherited
    81296,81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.09898Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.1026Inherited
    47473,47473,57850
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.1506Inherited
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.2203Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.2501Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.2561Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.5501Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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