SUPERFAMILY 1.75 HMM library and genome assignments server

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Mammalian Phenotype (MP): nervous system phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   nervous system phenotype [MP:0003631] <2>(98|127) (112|79|50)
- 1:   abnormal nervous system physiology [MP:0003633] <38>(43|59) (51|31|18)
- 1:   abnormal nervous system morphology [MP:0003632] <17>(76|104) (91|64|47)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Proton glutamate symport protein0Direct
Synuclein0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Metallothionein0Direct
Notch domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
E2F-DP heterodimerization region0Direct
Tubby C-terminal domain-like0Direct
Hedgehog/intein (Hint) domain0Direct
Oligoxyloglucan reducing end-specific cellobiohydrolase0Direct
Composite domain of metallo-dependent hydrolases0Direct
Hedgehog/DD-peptidase0Direct
Lamin A/C globular tail domain0Direct
Homeodomain-like0.0000000000008443Direct
Nicotinic receptor ligand binding domain-like0.0000000003546Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0000000003546Direct
Periplasmic binding protein-like I0.00000002825Direct
PDZ domain-like0.000003366Direct
HLH, helix-loop-helix DNA-binding domain0.00002416Direct
Voltage-gated potassium channels0.00003854Direct
Spectrin repeat0.0001243Direct
Periplasmic binding protein-like II0.0001255Direct
Sema domain0.0001591Direct
Nuclear receptor ligand-binding domain0.000226Direct
Plexin repeat0.0002901Direct
NHL repeat0.000339Direct
Frizzled cysteine-rich domain0.000527Direct
Galactose-binding domain-like0.001569Inherited
L27 domain0.001738Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.005348Inherited
Family A G protein-coupled receptor-like0.006265Inherited
Fibronectin type III0.007465Inherited
Orange domain-like0.008303Inherited
Caspase-like0.01069Inherited
YWTD domain0.01317Inherited
GAF domain-like0.01751Inherited
EGF/Laminin0.02265Inherited
Concanavalin A-like lectins/glucanases0.02375Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.02455Inherited
p53-like transcription factors0.02688Inherited
SMAD MH1 domain0.02861Inherited
Cupredoxins0.04274Inherited
SNF-like0.04274Inherited
Doublecortin (DC)0.05363Inherited
HCP-like0.05363Inherited
SH3-domain0.05933Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.06735Inherited
Riboflavin synthase domain-like0.06735Inherited
Metallo-dependent hydrolases0.06735Inherited
HMA, heavy metal-associated domain0.07325Inherited
GDNF receptor-like0.07325Inherited
SRF-like0.07325Inherited
Growth factor receptor domain0.08606Inherited
lambda repressor-like DNA-binding domains0.0868Inherited
Clc chloride channel0.1064Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain0.1064Inherited
GTPase activation domain, GAP0.1173Inherited
TIMP-like0.1293Inherited
Cysteine-rich domain0.1664Inherited
Kringle-like0.1676Inherited
Cystine-knot cytokines0.1678Inherited
L domain-like0.1696Inherited
PH domain-like0.1703Inherited
Bcl-2 inhibitors of programmed cell death0.1725Inherited
Flavoproteins0.1747Inherited
Cap-Gly domain0.1747Inherited
Cadherin-like0.1894Inherited
SNARE fusion complex0.1909Inherited
cAMP-binding domain-like0.1943Inherited
4-helical cytokines0.2365Inherited
Cyclin-like0.2385Inherited
Immunoglobulin0.2462Inherited
Zn-dependent exopeptidases0.2596Inherited
Formate/glycerate dehydrogenase catalytic domain-like0.2763Inherited
CBS-domain pair0.3012Inherited
Second domain of FERM0.3112Inherited
Integrin domains0.4381Inherited
SAM/Pointed domain0.4806Inherited
Spermadhesin, CUB domain0.4869Inherited
PLP-dependent transferases0.5051Inherited
MFS general substrate transporter0.5259Inherited
HD-domain/PDEase-like0.5438Inherited
BAR/IMD domain-like0.5733Inherited
HMG-box0.6032Inherited
TNF receptor-like0.6051Inherited
Toll/Interleukin receptor TIR domain0.6212Inherited
Bromodomain0.6466Inherited
PreATP-grasp domain0.6706Inherited
Intermediate filament protein, coiled coil region0.7137Inherited
Complement control module/SCR domain0.7391Inherited
FAD/NAD(P)-binding domain0.7726Inherited
ABC transporter transmembrane region0.8394Inherited
Glutathione synthetase ATP-binding domain-like0.8772Inherited
SAP domain0.89Inherited
beta-beta-alpha zinc fingers0.9347Inherited
alpha/beta-Hydrolases0.9746Inherited
RNA-binding domain, RBD0.9998Inherited
Cysteine proteinases1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
Lamin A/C globular tail domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Other IPT/TIG domains0Direct
Hedgehog (development protein), N-terminal signaling domain0Direct
Hydantoinase (dihydropyrimidinase), catalytic domain0Direct
Hydantoinase (dihydropyrimidinase)0Direct
Transcriptional factor tubby, C-terminal domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
Notch domain0Direct
Oligoxyloglucan reducing end-specific cellobiohydrolase0Direct
Proton glutamate symport protein0Direct
Metallothionein0Direct
E2F dimerization segment0Direct
Hedgehog C-terminal (Hog) autoprocessing domain0Direct
Synapsin domain0Direct
Neurotrophin0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Synuclein0Direct
Synapsin C-terminal domain0Direct
Homeodomain0.000000000002245Direct
Nicotinic receptor ligand binding domain-like0.0000000004001Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0000000004001Direct
L-arabinose binding protein-like0.0000006828Direct
Laminin G-like module0.000001353Direct
Phosphate binding protein-like0.000005016Direct
PDZ domain0.00002325Direct
HLH, helix-loop-helix DNA-binding domain0.00003328Direct
Nuclear receptor0.00006422Direct
Sema domain0.0001385Direct
Nuclear receptor ligand-binding domain0.0002244Direct
Plexin repeat0.000268Direct
Frizzled cysteine-rich domain0.0004268Direct
Spectrin repeat0.0007553Direct
Laminin-type module0.0008429Direct
L27 domain0.001302Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.002299Inherited
DEP domain0.002922Inherited
Caspase catalytic domain0.002922Inherited
Rhodopsin-like0.003427Inherited
Voltage-gated potassium channels0.004643Inherited
Ephrin ectodomain0.006398Inherited
Hairy Orange domain0.006398Inherited
Fibronectin type III0.01011Inherited
YWTD domain0.01098Inherited
Cell cycle transcription factor e2f-dp0.01198Inherited
Paired domain0.01198Inherited
I set domains0.01304Inherited
DIX domain0.01378Inherited
GAF domain0.01378Inherited
LDL receptor-like module0.0232Inherited
SMAD domain0.02341Inherited
SMAD MH1 domain0.02341Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.0291Inherited
NADPH-cytochrome p450 reductase-like0.0291Inherited
Extracellular domain of cell surface receptors0.02988Inherited
Enabled/VASP homology 1 domain (EVH1 domain)0.02988Inherited
SNF-like0.03696Inherited
cAMP-binding domain0.03738Inherited
L domain0.04465Inherited
Doublecortin (DC)0.04465Inherited
HMA, heavy metal-associated domain0.06075Inherited
beta-glycanases0.06075Inherited
SRF-like0.06075Inherited
Mib/herc2 domain0.06075Inherited
Formate/glycerate dehydrogenases, substrate-binding domain0.06075Inherited
GDNF receptor-like0.06075Inherited
Multidrug efflux transporter AcrB transmembrane domain0.06075Inherited
SH3-domain0.07368Inherited
Pyridoxal-dependent decarboxylase0.0833Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain0.09342Inherited
Clc chloride channel0.09342Inherited
Ephrin receptor ligand binding domain0.09706Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.09706Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.09757Inherited
Forkhead DNA-binding domain0.1046Inherited
Ngr ectodomain-like0.1196Inherited
EGF-type module0.1272Inherited
Phosphotyrosine-binding domain (PTB)0.1297Inherited
POU-specific domain0.1342Inherited
EF-hand modules in multidomain proteins0.1342Inherited
Bcl-2 inhibitors of programmed cell death0.1565Inherited
Cap-Gly domain0.1571Inherited
Tetramerization domain of potassium channels0.1806Inherited
SNARE fusion complex0.1806Inherited
Cadherin0.202Inherited
Long-chain cytokines0.2044Inherited
Motor proteins0.2082Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.2154Inherited
CBS-domain pair0.2172Inherited
Calmodulin-like0.2183Inherited
Synaptotagmin-like (S variant)0.2297Inherited
Fibronectin type II module0.2305Inherited
Adenylyl and guanylyl cyclase catalytic domain0.2321Inherited
SAM (sterile alpha motif) domain0.2373Inherited
Formate/glycerate dehydrogenases, NAD-domain0.2558Inherited
Leucine zipper domain0.2827Inherited
Transforming growth factor (TGF)-beta0.2941Inherited
Acetylcholinesterase-like0.3109Inherited
PLC-like (P variant)0.3137Inherited
FYVE, a phosphatidylinositol-3-phosphate binding domain0.3625Inherited
Cyclin0.3736Inherited
Cytoplasmic domain of inward rectifier potassium channel0.3939Inherited
Growth factor receptor domain0.3939Inherited
PDEase0.4043Inherited
p120GAP domain-like0.4305Inherited
Integrin domains0.4362Inherited
C1 set domains (antibody constant domain-like)0.438Inherited
Actin/HSP700.438Inherited
Integrin alpha N-terminal domain0.438Inherited
Spermadhesin, CUB domain0.4965Inherited
TNF receptor-like0.5109Inherited
HMG-box0.6135Inherited
Bromodomain0.6501Inherited
G proteins0.6871Inherited
Toll/Interleukin receptor TIR domain0.7123Inherited
Intermediate filament protein, coiled coil region0.7229Inherited
Complement control module/SCR domain0.7457Inherited
BAR domain0.7465Inherited
ABC transporter transmembrane region0.8396Inherited
SAP domain0.8858Inherited
MAM domain0.8858Inherited
Classic zinc finger, C2H20.8998Inherited
ABC transporter ATPase domain-like0.915Inherited
SH2 domain0.926Inherited
Canonical RBD0.9693Inherited
V set domains (antibody variable domain-like)1Inherited


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Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Oligoxyloglucan reducing end-specific cellobiohydrolase0Direct
E2F-DP heterodimerization region0Direct
Hedgehog/intein (Hint) domain0Direct
Proton glutamate symport protein0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
Notch domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Hedgehog/DD-peptidase0Direct
Composite domain of metallo-dependent hydrolases0Direct
Metallothionein0Direct
Synuclein0Direct
Lamin A/C globular tail domain0Direct
Tubby C-terminal domain-like0Direct
Homeodomain-like0.0000000000003061Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0000000001303Direct
Nicotinic receptor ligand binding domain-like0.0000000001303Direct
Periplasmic binding protein-like I0.00000001081Direct
PDZ domain-like0.000001425Direct
HLH, helix-loop-helix DNA-binding domain0.00001097Direct
Voltage-gated potassium channels0.00001783Direct
Spectrin repeat0.00006114Direct
Periplasmic binding protein-like II0.00006173Direct
Sema domain0.00007954Direct
Nuclear receptor ligand-binding domain0.0001146Direct
Plexin repeat0.0001489Direct
NHL repeat0.0001763Direct
Frizzled cysteine-rich domain0.0002789Direct
Galactose-binding domain-like0.0008803Direct
L27 domain0.0009814Direct
Glucocorticoid receptor-like (DNA-binding domain)0.003216Inherited
Family A G protein-coupled receptor-like0.003808Inherited
Fibronectin type III0.004582Inherited
Orange domain-like0.00513Inherited
Caspase-like0.006716Inherited
YWTD domain0.008383Inherited
GAF domain-like0.0114Inherited
EGF/Laminin0.01502Inherited
Concanavalin A-like lectins/glucanases0.01582Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.01641Inherited
LDL receptor-like module0.01649Inherited
p53-like transcription factors0.01809Inherited
SMAD MH1 domain0.01937Inherited
SNF-like0.02983Inherited
Cupredoxins0.02983Inherited
HCP-like0.0381Inherited
Doublecortin (DC)0.0381Inherited
E set domains0.04234Inherited
SH3-domain0.04265Inherited
Metallo-dependent hydrolases0.04908Inherited
Riboflavin synthase domain-like0.04908Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.04908Inherited
SRF-like0.05378Inherited
GDNF receptor-like0.05378Inherited
HMA, heavy metal-associated domain0.05378Inherited
Mib/herc2 domain-like0.05378Inherited
Growth factor receptor domain0.06402Inherited
lambda repressor-like DNA-binding domains0.06461Inherited
Glutamine synthetase/guanido kinase0.07305Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain0.08097Inherited
Clc chloride channel0.08097Inherited
Multidrug efflux transporter AcrB transmembrane domain0.08097Inherited
GTPase activation domain, GAP0.09038Inherited
TIMP-like0.1005Inherited
Cysteine-rich domain0.133Inherited
Kringle-like0.1341Inherited
Cystine-knot cytokines0.1343Inherited
L domain-like0.1357Inherited
PH domain-like0.1364Inherited
Bcl-2 inhibitors of programmed cell death0.1384Inherited
Flavoproteins0.1403Inherited
Cap-Gly domain0.1403Inherited
Cadherin-like0.1537Inherited
SNARE fusion complex0.155Inherited
cAMP-binding domain-like0.1582Inherited
BRCT domain0.1724Inherited
4-helical cytokines0.1972Inherited
Cyclin-like0.1991Inherited
Nucleotide cyclase0.2018Inherited
Immunoglobulin0.2063Inherited
Zn-dependent exopeptidases0.2187Inherited
Leucine zipper domain0.2327Inherited
Formate/glycerate dehydrogenase catalytic domain-like0.2345Inherited
CBS-domain pair0.2579Inherited
Second domain of FERM0.2675Inherited
"Winged helix" DNA-binding domain0.3019Inherited
ARM repeat0.3232Inherited
Quinoprotein alcohol dehydrogenase-like0.3285Inherited
Integrin domains0.3906Inherited
TPR-like0.402Inherited
Integrin alpha N-terminal domain0.4228Inherited
SAM/Pointed domain0.433Inherited
Spermadhesin, CUB domain0.4394Inherited
PLP-dependent transferases0.4575Inherited
MFS general substrate transporter0.4786Inherited
HD-domain/PDEase-like0.497Inherited
BAR/IMD domain-like0.5269Inherited
HMG-box0.5577Inherited
TNF receptor-like0.5597Inherited
Toll/Interleukin receptor TIR domain0.5764Inherited
Bromodomain0.6031Inherited
PreATP-grasp domain0.6282Inherited
Intermediate filament protein, coiled coil region0.6738Inherited
Complement control module/SCR domain0.7006Inherited
FAD/NAD(P)-binding domain0.7356Inherited
ABC transporter transmembrane region0.8076Inherited
Glutathione synthetase ATP-binding domain-like0.8484Inherited
SAP domain0.8623Inherited
SH2 domain0.8823Inherited
beta-beta-alpha zinc fingers0.9113Inherited
alpha/beta-Hydrolases0.9565Inherited
RNA-binding domain, RBD0.9868Inherited
Cysteine proteinases1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    101288,50156
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 0Direct
    55166,51294
  • 55166 - Hedgehog/DD-peptidase
  • 51294 - Hedgehog/intein (Hint) domain
  • 0Direct
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    46966,51045
  • 46966 - Spectrin repeat
  • 51045 - WW domain
  • 0Direct
    50729,57889
  • 50729 - PH domain-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0Direct
    56496,49899
  • 56496 - Fibrinogen C-terminal domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    49785,49899
  • 49785 - Galactose-binding domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    50044,50156
  • 50044 - SH3-domain
  • 50156 - PDZ domain-like
  • 0Direct
    50729,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57196,56496
  • 57196 - EGF/Laminin
  • 56496 - Fibrinogen C-terminal domain-like
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    48726,82895
  • 48726 - Immunoglobulin
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    51338,51556
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 0Direct
    81296,101898
  • 81296 - E set domains
  • 101898 - NHL repeat
  • 0Direct
    51556,51338
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0Direct
    51045,47473
  • 51045 - WW domain
  • 47473 - EF-hand
  • 0Direct
    49562,51045
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 51045 - WW domain
  • 0Direct
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    47473,57850
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.0000000001303Direct
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0.00001153Direct
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.00007954Direct
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.0001582Direct
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.0001901Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0002206Direct
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.0002789Direct
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.0009814Direct
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.00513Inherited
    47459,158457
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 158457 - Orange domain-like
  • 0.00513Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.00609Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.009603Inherited
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.0114Inherited
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0.0114Inherited
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.0114Inherited
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.0114Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.0114Inherited
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.01711Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.01937Inherited
    103575,48726
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0.02465Inherited
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0.02508Inherited
    57184,49265
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0.02508Inherited
    81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.03102Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0381Inherited
    57196,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.0381Inherited
    89837,89837
  • 89837 - Doublecortin (DC)
  • 89837 - Doublecortin (DC)
  • 0.0381Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0381Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.0381Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.04883Inherited
    57535,49854
  • 57535 - Complement control module/SCR domain
  • 49854 - Spermadhesin, CUB domain
  • 0.05378Inherited
    48452,81901
  • 48452 - TPR-like
  • 81901 - HCP-like
  • 0.05378Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.05737Inherited
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.07184Inherited
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0.07184Inherited
    81324,81324
  • 81324 - Voltage-gated potassium channels
  • 81324 - Voltage-gated potassium channels
  • 0.08097Inherited
    56112,47769
  • 56112 - Protein kinase-like (PK-like)
  • 47769 - SAM/Pointed domain
  • 0.08145Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.08363Inherited
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0.1403Inherited
    56112,55073
  • 56112 - Protein kinase-like (PK-like)
  • 55073 - Nucleotide cyclase
  • 0.1403Inherited
    52058,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 0.1926Inherited
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.2121Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.2153Inherited
    52283,51735
  • 52283 - Formate/glycerate dehydrogenase catalytic domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.2345Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.3349Inherited
    49854,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0.3397Inherited
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0.3606Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.3606Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.37Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.4319Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.4319Inherited
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.5361Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.5404Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.8066Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.8076Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.841Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.8729Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    101288,50156,50044
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 0Direct
    57196,56496,49899
  • 57196 - EGF/Laminin
  • 56496 - Fibrinogen C-terminal domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    50729,50156,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    49785,49899,49899
  • 49785 - Galactose-binding domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    47473,47473,57850
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0Direct
    75399,75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    56496,49899,49899
  • 56496 - Fibrinogen C-terminal domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    46966,51045,47473
  • 46966 - Spectrin repeat
  • 51045 - WW domain
  • 47473 - EF-hand
  • 0Direct
    49899,57196,56496
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 56496 - Fibrinogen C-terminal domain-like
  • 0Direct
    48726,48726,82895
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    49503,49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    63411,63411,63411
  • 63411 - LuxS/MPP-like metallohydrolase
  • 63411 - LuxS/MPP-like metallohydrolase
  • 63411 - LuxS/MPP-like metallohydrolase
  • 0Direct
    48726,82895,82895
  • 48726 - Immunoglobulin
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    46966,46966,51045
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 51045 - WW domain
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    52058,48726,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0Direct
    51045,47473,47473
  • 51045 - WW domain
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0Direct
    51338,51556,51338
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0Direct
    49899,49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0Direct
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.0004039Direct
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0004122Direct
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.0004648Direct
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.002191Inherited
    49899,57196,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.002259Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.003392Inherited
    81296,81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.003392Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.003915Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.00441Inherited
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.0114Inherited
    50044,50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.0114Inherited
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.0114Inherited
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.0114Inherited
    101912,103575,48726
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0.02465Inherited
    48065,50729,50044
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 0.02508Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0381Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.05063Inherited
    49854,57535,49854
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 49854 - Spermadhesin, CUB domain
  • 0.05378Inherited
    57535,49854,57535
  • 57535 - Complement control module/SCR domain
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0.05378Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.1335Inherited
    49854,57535,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.2345Inherited
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.3Inherited
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.3319Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.4319Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.6054Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.6647Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.9718Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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