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Mammalian Phenotype (MP): abnormal synaptic transmission

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   nervous system phenotype [MP:0003631] <2>(98|127) (112|79|50)
+ 1:   abnormal nervous system physiology [MP:0003633] <38>(43|58) (51|31|18)
0:   abnormal synaptic transmission [MP:0003635] <8>(23|28) (27|14|6)
- 1:   abnormal CNS synaptic transmission [MP:0002206] <14>(18|21) (24|14|6)
- 1:   abnormal neurotransmitter secretion [MP:0005445] <7>(1|3) (1|1|1)
- 1:   abnormal PNS synaptic transmission [MP:0002913] <2>(2|4) (3|1|0)
- 1:   abnormal channel response [MP:0003484] <2>(1|2) (1|0|0)
- 1:   abnormal paired-pulse facilitation [MP:0002918] <2>(2|4) (2|1|0)
- 1:   abnormal neurotransmitter level [MP:0002204](1|1) (1|0|0)
- 1:   abnormal neurotransmitter uptake [MP:0003444](1|0) (1|0|0)
- 1:   abnormal paired-pulse inhibition [MP:0004807](1|1) (1|1|1)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Periplasmic binding protein-like II0.000000000007954Direct
Nicotinic receptor ligand binding domain-like0.000001654Direct
Neurotransmitter-gated ion-channel transmembrane pore0.000001654Direct
PDZ domain-like0.000003798Direct
Periplasmic binding protein-like I0.00001352Direct
SRF-like0.001028Inherited
SNF-like0.01353Inherited
Cysteine-rich domain0.02917Inherited
BAR/IMD domain-like0.03455Inherited
Voltage-gated potassium channels0.03665Inherited
PreATP-grasp domain0.04106Inherited
SNARE fusion complex0.04392Inherited
Zn-dependent exopeptidases0.05684Inherited
Complement control module/SCR domain0.0892Inherited
PLP-dependent transferases0.1048Inherited
SH3-domain0.1526Inherited
Glutathione synthetase ATP-binding domain-like0.2115Inherited
L27 domain0.2235Inherited
MFS general substrate transporter0.264Inherited
Spermadhesin, CUB domain0.3172Inherited
Riboflavin synthase domain-like0.3349Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.3349Inherited
Concanavalin A-like lectins/glucanases0.3736Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Synapsin domain0Direct
Synapsin C-terminal domain0Direct
Phosphate binding protein-like0.0000000000004218Direct
Neurotransmitter-gated ion-channel transmembrane pore0.000001142Direct
Nicotinic receptor ligand binding domain-like0.000001142Direct
PDZ domain0.00003387Direct
L-arabinose binding protein-like0.000136Direct
Pyridoxal-dependent decarboxylase0.000394Direct
SRF-like0.0007037Direct
Synaptotagmin-like (S variant)0.004675Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.008537Inherited
SNF-like0.009981Inherited
SNARE fusion complex0.03447Inherited
Ephrin ectodomain0.03935Inherited
BAR domain0.03976Inherited
Phosphotyrosine-binding domain (PTB)0.05353Inherited
Complement control module/SCR domain0.08132Inherited
Laminin G-like module0.09183Inherited
YWTD domain0.1083Inherited
SH3-domain0.1416Inherited
G proteins0.1645Inherited
Acetylcholinesterase-like0.184Inherited
C1 set domains (antibody constant domain-like)0.1982Inherited
L27 domain0.1982Inherited
SAM (sterile alpha motif) domain0.2257Inherited
Spermadhesin, CUB domain0.2908Inherited
Voltage-gated potassium channels0.2927Inherited
Tetramerization domain of potassium channels0.4046Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Periplasmic binding protein-like II0.000000000002885Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0000006796Direct
Nicotinic receptor ligand binding domain-like0.0000006796Direct
PDZ domain-like0.000001619Direct
Periplasmic binding protein-like I0.000005986Direct
SRF-like0.0005616Direct
SNF-like0.00865Inherited
Cysteine-rich domain0.0198Inherited
BAR/IMD domain-like0.02376Inherited
Voltage-gated potassium channels0.02527Inherited
PreATP-grasp domain0.02858Inherited
SNARE fusion complex0.03074Inherited
Nuclear receptor ligand-binding domain0.03792Inherited
Zn-dependent exopeptidases0.04073Inherited
Complement control module/SCR domain0.06664Inherited
PLP-dependent transferases0.07954Inherited
YWTD domain0.09991Inherited
SH3-domain0.1211Inherited
Glutathione synthetase ATP-binding domain-like0.1739Inherited
Cupredoxins0.1852Inherited
L27 domain0.1852Inherited
MFS general substrate transporter0.2229Inherited
Spermadhesin, CUB domain0.2732Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.2901Inherited
Riboflavin synthase domain-like0.2901Inherited
Concanavalin A-like lectins/glucanases0.3277Inherited
alpha/beta-Hydrolases0.5043Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    50044,50156
  • 50044 - SH3-domain
  • 50156 - PDZ domain-like
  • 0Direct
    50729,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.0000006796Direct
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0.000007289Direct
    57535,49854
  • 57535 - Complement control module/SCR domain
  • 49854 - Spermadhesin, CUB domain
  • 0.0005616Direct
    49854,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0.008481Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.02053Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.02835Inherited
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.03074Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.05233Inherited
    101288,50156
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 0.09991Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.1303Inherited
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.2628Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,50156,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    57535,49854,57535
  • 57535 - Complement control module/SCR domain
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0.0005616Direct
    49854,57535,49854
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 49854 - Spermadhesin, CUB domain
  • 0.0005616Direct
    49854,57535,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.004579Inherited
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.03573Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.1378Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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