SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Mammalian Phenotype (MP): abnormal hormone level

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
+ 1:   abnormal homeostasis [MP:0001764] <27>(103|129) (113|73|31)
0:   abnormal hormone level [MP:0003953] <15>(27|29) (30|17|8)
- 1:   abnormal circulating hormone level [MP:0005418] <26>(24|23) (25|13|4)
- 1:   abnormal pituitary hormone level [MP:0003965] <9>(7|7) (8|2|0)
- 1:   abnormal thyroid hormone level [MP:0005468] <4>(2|3) (2|1|0)
- 1:   abnormal urine hormone level [MP:0011538] <4>(0|0) (0|0|0)
- 1:   abnormal erythropoietin level [MP:0011283] <3>(0|0) (0|0|0)
- 1:   abnormal noradrenaline level [MP:0003964] <3>(2|2) (2|1|0)
- 1:   abnormal serotonin level [MP:0005322] <3>(2|2) (2|1|0)
- 1:   abnormal adiponectin level [MP:0004891] <2>(4|4) (4|0|0)
- 1:   abnormal aldosterone level [MP:0011415] <2>(1|1) (1|0|0)
- 1:   abnormal corticosterone level [MP:0003963] <2>(1|1) (1|0|0)
- 1:   abnormal progesterone level [MP:0011384] <2>(1|2) (1|0|0)
- 1:   abnormal adrenaline level [MP:0003962] <1>(0|0) (0|0|0)
- 1:   abnormal insulin-like growth factor I level [MP:0008831] <1>(5|6) (5|5|2)
- 1:   abnormal testosterone level [MP:0011385] <1>(2|2) (2|1|0)
- 1:   abnormal somatostatin level [MP:0011067](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Family A G protein-coupled receptor-like0.00000005609Direct
Nuclear receptor ligand-binding domain0.0000007643Direct
PYP-like sensor domain (PAS domain)0.00001912Direct
KA1-like0.00006258Direct
Hormone receptor domain0.0003492Direct
ACT-like0.0003936Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0004821Direct
Flavoproteins0.003589Inherited
GroEL equatorial domain-like0.007271Inherited
Heme-dependent peroxidases0.007343Inherited
SMAD MH1 domain0.01288Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.02571Inherited
Riboflavin synthase domain-like0.02571Inherited
Nuclear receptor coactivator interlocking domain0.02737Inherited
Transcription factor STAT-4 N-domain0.03103Inherited
STAT0.03103Inherited
HLH, helix-loop-helix DNA-binding domain0.05491Inherited
Thyroglobulin type-1 domain0.07857Inherited
CAD & PB1 domains0.1044Inherited
ClpP/crotonase0.1282Inherited
Cystine-knot cytokines0.1797Inherited
Transducin (alpha subunit), insertion domain0.206Inherited
Cytochrome P4500.2638Inherited
Thioredoxin-like0.3386Inherited
p53-like transcription factors0.7245Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Phenylalanine metabolism regulatory domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Nuclear receptor ligand-binding domain0.0000005342Direct
Nuclear receptor0.0000005771Direct
Rhodopsin-like0.000005838Direct
Hormone receptor domain0.0002324Direct
Hypoxia-inducible factor Hif2a, C-terminal domain0.0004602Direct
Insulin-like0.0007994Direct
Phosphotyrosine-binding domain (PTB)0.0009843Direct
Kinase associated domain 1, KA10.001595Inherited
Myeloperoxidase-like0.005593Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.007209Inherited
NADPH-cytochrome p450 reductase-like0.007209Inherited
SMAD domain0.009396Inherited
SMAD MH1 domain0.009396Inherited
Nuclear receptor coactivator interlocking domain0.02043Inherited
Forkhead DNA-binding domain0.02258Inherited
STAT0.0236Inherited
Transcription factor STAT-4 N-domain0.0236Inherited
STAT DNA-binding domain0.0236Inherited
HLH, helix-loop-helix DNA-binding domain0.05485Inherited
Thyroglobulin type-1 domain0.06795Inherited
Papain-like0.1271Inherited
Transforming growth factor (TGF)-beta0.1492Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.1672Inherited
Transducin (alpha subunit), insertion domain0.1813Inherited
Cytochrome P4500.2426Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Family A G protein-coupled receptor-like0.00000002167Direct
Nuclear receptor ligand-binding domain0.0000003092Direct
PYP-like sensor domain (PAS domain)0.00000853Direct
KA1-like0.00002953Direct
Hormone receptor domain0.0001816Direct
ACT-like0.0002053Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0002539Direct
Insulin-like0.0006761Direct
t-snare proteins0.002104Inherited
Flavoproteins0.002104Inherited
GroEL equatorial domain-like0.004466Inherited
Heme-dependent peroxidases0.004515Inherited
SMAD MH1 domain0.008201Inherited
Riboflavin synthase domain-like0.01725Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.01725Inherited
Nuclear receptor coactivator interlocking domain0.01845Inherited
Transcription factor STAT-4 N-domain0.02119Inherited
STAT0.02119Inherited
HLH, helix-loop-helix DNA-binding domain0.03913Inherited
Thyroglobulin type-1 domain0.05794Inherited
CAD & PB1 domains0.0792Inherited
ClpP/crotonase0.09958Inherited
Cystine-knot cytokines0.145Inherited
Transducin (alpha subunit), insertion domain0.1687Inherited
Cytochrome P4500.2225Inherited
Thioredoxin-like0.2936Inherited
SMAD/FHA domain0.4193Inherited
p53-like transcription factors0.685Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    55021,56534
  • 55021 - ACT-like
  • 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
  • 0Direct
    52058,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.00002478Direct
    111418,81321
  • 111418 - Hormone receptor domain
  • 81321 - Family A G protein-coupled receptor-like
  • 0.00005607Direct
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.0001647Direct
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.001038Inherited
    57184,57610
  • 57184 - Growth factor receptor domain
  • 57610 - Thyroglobulin type-1 domain
  • 0.009875Inherited
    47769,47769
  • 47769 - SAM/Pointed domain
  • 47769 - SAM/Pointed domain
  • 0.01845Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.02119Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.02119Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.02119Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.05237Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1209Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.1565Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.2195Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.5286Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    52058,49265,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0Direct
    57184,52058,49265
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.0004519Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.02119Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.02119Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.1565Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)