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Mammalian Phenotype (MP): abnormal neuron physiology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   nervous system phenotype [MP:0003631] <2>(98|127) (112|79|50)
+ 1:   abnormal nervous system physiology [MP:0003633] <38>(43|58) (51|31|18)
0:   abnormal neuron physiology [MP:0004811] <12>(8|12) (11|7|5)
- 1:   abnormal sensory neuron physiology [MP:0010055] <5>(0|0) (0|1|0)
- 1:   abnormal neuron apoptosis [MP:0003202] <2>(2|4) (3|1|0)
- 1:   abnormal neuron proliferation [MP:0009967] <2>(1|1) (2|0|1)
- 1:   abnormal neuronal migration [MP:0006009] <2>(2|3) (2|3|1)
- 1:   abnormal Wallerian degeneration [MP:0010653] <1>(0|0) (0|0|0)
- 1:   abnormal collateral sprouting [MP:0010726] <1>(0|0) (0|0|0)
- 1:   abnormal GABAergic neuron physiology [MP:0011987](0|0) (0|0|0)
- 1:   abnormal axonal transport [MP:0004768](0|1) (1|0|0)
- 1:   abnormal synaptic vesicle clustering [MP:0004793](0|0) (0|0|0)
- 1:   abnormal synaptic vesicle recycling [MP:0004770](2|2) (2|0|0)
- 1:   decreased brain acetylcholinesterase activity [MP:0012626](0|0) (0|0|0)
- 1:   increased brain acetylcholinesterase activity [MP:0012627](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Caspase-like0.00001882Direct
SRF-like0.0007389Direct
Sema domain0.0099Inherited
Plexin repeat0.04095Inherited
BAR/IMD domain-like0.1094Inherited
HLH, helix-loop-helix DNA-binding domain0.1305Inherited
SH3-domain0.2893Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Retinoblastoma tumor suppressor domains0Direct
Caspase catalytic domain0.000005103Direct
SRF-like0.0004936Direct
Sema domain0.007244Inherited
BAR domain0.02836Inherited
Plexin repeat0.03244Inherited
Intermediate filament protein, coiled coil region0.04068Inherited
MAM domain0.0667Inherited
HLH, helix-loop-helix DNA-binding domain0.1154Inherited
Toll/Interleukin receptor TIR domain0.1451Inherited
SH3-domain0.2738Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Caspase-like0.000008379Direct
SRF-like0.0003964Direct
Sema domain0.006187Inherited
Homeodomain-like0.02652Inherited
Plexin repeat0.0285Inherited
Intermediate filament protein, coiled coil region0.03225Inherited
BAR/IMD domain-like0.08359Inherited
HLH, helix-loop-helix DNA-binding domain0.1018Inherited
SH3-domain0.2467Inherited
Leucine zipper domain0.7018Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.000192Direct
    48726,82895
  • 48726 - Immunoglobulin
  • 82895 - TSP-1 type 1 repeat
  • 0.0003964Direct
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.006187Inherited
    103575,48726
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0.02403Inherited
    49785,49899
  • 49785 - Galactose-binding domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.1319Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.1319Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.8113Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48726,82895,82895
  • 48726 - Immunoglobulin
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.0003964Direct
    101288,50156,50044
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 0.0003964Direct
    48726,48726,82895
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 82895 - TSP-1 type 1 repeat
  • 0.0003964Direct
    101912,103575,48726
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0.02403Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.2165Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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