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Mammalian Phenotype (MP): abnormal response to infection

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ 1:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
0:   abnormal response to infection [MP:0005025] <2>(18|31) (21|17|5)
- 1:   altered susceptibility to infection [MP:0001793] <8>(18|31) (21|17|5)
- 1:   sepsis [MP:0005044](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
4-helical cytokines0.0002072Direct
Triple coiled coil domain of C-type lectins0.000546Direct
DEATH domain0.0008405Direct
p53-like transcription factors0.001744Inherited
C-type lectin-like0.002854Inherited
Toll/Interleukin receptor TIR domain0.004091Inherited
PGBD-like0.007323Inherited
Transcription factor STAT-4 N-domain0.01619Inherited
STAT0.01619Inherited
RNI-like0.02724Inherited
Hemopexin-like domain0.02883Inherited
dsRNA-binding domain-like0.03745Inherited
MHC antigen-recognition domain0.09745Inherited
Alpha-macroglobulin receptor domain0.1452Inherited
Immunoglobulin0.183Inherited
TNF receptor-like0.2938Inherited
Caspase-like0.4394Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
Interferon regulatory factor0.000000001939Direct
Interferon regulatory factor 3 (IRF3), transactivation domain0.0000003091Direct
Triple coiled coil domain of C-type lectins0.000358Direct
C-type lectin domain0.0003729Direct
Netrin-like domain (NTR/C345C module)0.001295Inherited
Caspase recruitment domain, CARD0.005118Inherited
Matrix metalloproteases, catalytic domain0.005118Inherited
MMP N-terminal domain0.005118Inherited
Toll/Interleukin receptor TIR domain0.005689Inherited
DEATH domain, DD0.007926Inherited
Interleukin 17F, IL-17F0.008743Inherited
STAT0.01161Inherited
Long-chain cytokines0.01161Inherited
Interferons/interleukin-10 (IL-10)0.01161Inherited
Transcription factor STAT-4 N-domain0.01161Inherited
STAT DNA-binding domain0.01161Inherited
Hemopexin-like domain0.02157Inherited
Short-chain cytokines0.02157Inherited
Eukaryotic proteases0.02354Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.02461Inherited
Double-stranded RNA-binding domain (dsRBD)0.04287Inherited
C1 set domains (antibody constant domain-like)0.0454Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.05098Inherited
Fibronectin type II module0.06515Inherited
Interleukin-1 (IL-1)0.06515Inherited
MHC antigen-recognition domain0.07952Inherited
Complement components0.1212Inherited
Alpha-macroglobulin receptor domain0.1212Inherited
TNF receptor-like0.1737Inherited
Caspase catalytic domain0.3325Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
4-helical cytokines0.0001048Direct
Triple coiled coil domain of C-type lectins0.0002895Direct
DEATH domain0.0004546Direct
p53-like transcription factors0.0009847Direct
C-type lectin-like0.001652Inherited
Toll/Interleukin receptor TIR domain0.002414Inherited
PGBD-like0.004501Inherited
Transcription factor STAT-4 N-domain0.01048Inherited
STAT0.01048Inherited
RNI-like0.01835Inherited
Hemopexin-like domain0.01953Inherited
dsRNA-binding domain-like0.02587Inherited
Trypsin-like serine proteases0.0284Inherited
MHC antigen-recognition domain0.07343Inherited
TNF-like0.08678Inherited
Alpha-macroglobulin receptor domain0.1145Inherited
Immunoglobulin0.148Inherited
Integrin alpha N-terminal domain0.156Inherited
TNF receptor-like0.251Inherited
Caspase-like0.392Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.0002895Direct
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.004501Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.00593Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.006923Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.01048Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01048Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01048Inherited
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0.01163Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.01953Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.0472Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0472Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.0612Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.1071Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1145Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.1145Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.156Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01048Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01048Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.01953Inherited
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.0472Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.0612Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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