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Mammalian Phenotype (MP): abnormal metabolism

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
0:   abnormal metabolism [MP:0005266] <21>(26|21) (30|11|3)
- 1:   abnormal enzyme/coenzyme activity [MP:0005584] <41>(8|5) (8|1|0)
- 1:   abnormal DNA repair [MP:0008058] <4>(6|4) (6|2|0)
- 1:   abnormal xenobiotic metabolism [MP:0013275] <4>(0|0) (0|0|0)
- 1:   abnormal response/metabolism to endogenous compounds [MP:0003638] <3>(3|3) (3|1|0)
- 1:   abnormal aerobic fitness [MP:0000348] <2>(0|0) (1|0|0)
- 1:   abnormal basal metabolism [MP:0008961] <2>(0|2) (0|1|0)
- 1:   abnormal exercise endurance [MP:0002332] <2>(2|2) (2|1|0)
- 1:   abnormal lipid metabolism [MP:0013245] <1>(2|3) (2|0|0)
- 1:   abnormal response to radiation [MP:0012734] <1>(6|6) (6|3|1)
- 1:   abnormal translation [MP:0013272] <1>(0|0) (0|0|0)
- 1:   abnormal vitamin or vitamin cofactor metabolism [MP:0013274] <1>(1|0) (1|0|0)
- 1:   abnormal DNA replication [MP:0008057](1|0) (1|0|0)
- 1:   abnormal amino acid metabolism [MP:0013242](0|0) (0|0|0)
- 1:   abnormal carbohydrate metabolism [MP:0013243](0|0) (0|0|0)
- 1:   abnormal ethanol metabolism [MP:0005443](0|0) (0|0|0)
- 1:   abnormal haloperidol metabolism [MP:0012693](0|0) (0|0|0)
- 1:   abnormal lithium metabolism [MP:0012694](0|0) (0|0|0)
- 1:   abnormal nicotine metabolism [MP:0012695](0|0) (0|0|0)
- 1:   abnormal nucleotide metabolism [MP:0003806](1|1) (1|0|0)
- 1:   abnormal peptide metabolism [MP:0013246](0|0) (0|0|0)
- 1:   abnormal response to exercise [MP:0012735](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
ATP-dependent DNA ligase DNA-binding domain0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
WGR domain-like0Direct
Uracil-DNA glycosylase-like0Direct
BRCT domain0.0000008946Direct
Nuclear receptor ligand-binding domain0.0005045Direct
Domain of poly(ADP-ribose) polymerase0.0006454Direct
DNA repair protein MutS, domain III0.002183Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.004363Inherited
DNA polymerase beta, N-terminal domain-like0.005856Inherited
DNA-glycosylase0.005856Inherited
HMA, heavy metal-associated domain0.005856Inherited
Nucleic acid-binding proteins0.01119Inherited
Ran binding protein zinc finger-like0.0123Inherited
NAD(P)-binding Rossmann-fold domains0.01542Inherited
Calcium-dependent phosphotriesterase0.01742Inherited
Thioredoxin-like0.03247Inherited
Metallo-dependent hydrolases0.03744Inherited
SMAD/FHA domain0.0522Inherited
ADP-ribosylation0.08457Inherited
alpha/beta-Hydrolases0.1053Inherited
Calponin-homology domain, CH-domain0.1102Inherited
Spectrin repeat0.1421Inherited
Family A G protein-coupled receptor-like0.2114Inherited
P-loop containing nucleoside triphosphate hydrolases0.7023Inherited
SH3-domain0.963Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
DNA ligase/mRNA capping enzyme postcatalytic domain0Direct
ATP-dependent DNA ligase catalytic domain0Direct
WGR domain0Direct
Nuclear receptor0.000134Direct
Nuclear receptor ligand-binding domain0.0002897Direct
Domain of poly(ADP-ribose) polymerase0.0004033Direct
Adenosine/AMP deaminase0.0004033Direct
DNA repair protein MutS, domain III0.001448Inherited
FHA domain0.001479Inherited
HMA, heavy metal-associated domain0.003783Inherited
DNA polymerase beta, N-terminal domain-like0.003783Inherited
Poly(ADP-ribose) polymerase, C-terminal domain0.006253Inherited
Ran binding protein zinc finger-like0.008327Inherited
ABC transporter ATPase domain-like0.02115Inherited
Calponin-homology domain, CH-domain0.08749Inherited
Spectrin repeat0.1154Inherited
Rhodopsin-like0.2402Inherited
PHD domain0.241Inherited
Phosphotyrosine-binding domain (PTB)0.3203Inherited
Transforming growth factor (TGF)-beta0.4468Inherited
SH3-domain0.9592Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Uracil-DNA glycosylase-like0Direct
WGR domain-like0Direct
ATP-dependent DNA ligase DNA-binding domain0Direct
BRCT domain0.0000003638Direct
Nuclear receptor ligand-binding domain0.0002666Direct
Domain of poly(ADP-ribose) polymerase0.0003446Direct
PYP-like sensor domain (PAS domain)0.0006811Direct
Flavoproteins0.0006884Direct
Heme-dependent peroxidases0.0009564Direct
DNA repair protein MutS, domain III0.001246Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.002585Inherited
DNA-glycosylase0.003534Inherited
HMA, heavy metal-associated domain0.003534Inherited
DNA polymerase beta, N-terminal domain-like0.003534Inherited
Nucleic acid-binding proteins0.007062Inherited
Ran binding protein zinc finger-like0.00781Inherited
NAD(P)-binding Rossmann-fold domains0.009932Inherited
Calcium-dependent phosphotriesterase0.01136Inherited
Thioredoxin-like0.02221Inherited
Metallo-dependent hydrolases0.02586Inherited
SMAD/FHA domain0.03699Inherited
ADP-ribosylation0.06277Inherited
alpha/beta-Hydrolases0.08001Inherited
Calponin-homology domain, CH-domain0.08425Inherited
Spectrin repeat0.1117Inherited
Family A G protein-coupled receptor-like0.1737Inherited
P-loop containing nucleoside triphosphate hydrolases0.6615Inherited
EF-hand0.873Inherited
SH3-domain0.9431Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
142921,47587
  • 142921 - WGR domain-like
  • 47587 - Domain of poly(ADP-ribose) polymerase
  • 0Direct
    51735,50129
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    117018,56091
  • 117018 - ATP-dependent DNA ligase DNA-binding domain
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 0Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0002262Direct
    47587,56399
  • 47587 - Domain of poly(ADP-ribose) polymerase
  • 56399 - ADP-ribosylation
  • 0.0003446Direct
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0.0004469Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.001246Inherited
    57184,57610
  • 57184 - Growth factor receptor domain
  • 57610 - Thyroglobulin type-1 domain
  • 0.002918Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.1824Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.2534Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    142921,47587,56399
  • 142921 - WGR domain-like
  • 47587 - Domain of poly(ADP-ribose) polymerase
  • 56399 - ADP-ribosylation
  • 0Direct
    50129,51735,50129
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 0Direct
    117018,56091,50249
  • 117018 - ATP-dependent DNA ligase DNA-binding domain
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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