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Mammalian Phenotype (MP): muscle phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   muscle phenotype [MP:0005369] <2>(49|57) (54|37|28)
- 1:   abnormal muscle physiology [MP:0002106] <23>(25|33) (27|16|11)
- 1:   abnormal muscle morphology [MP:0002108] <16>(28|31) (31|22|21)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Troponin coil-coiled subunits0Direct
Lamin A/C globular tail domain0Direct
Protein kinase-like (PK-like)0.0000001322Direct
Glucocorticoid receptor-like (DNA-binding domain)0.000006263Direct
EGF/Laminin0.00001606Direct
Nuclear receptor ligand-binding domain0.00009358Direct
p53-like transcription factors0.0001114Direct
Growth factor receptor domain0.0001457Direct
Spectrin repeat0.0002436Direct
IP3 receptor type 1 binding core, domain 20.000388Direct
SMAD MH1 domain0.0004162Direct
TB module/8-cys domain0.0004162Direct
MIR domain0.0004162Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0.0008517Direct
Riboflavin synthase domain-like0.0008517Direct
Calponin-homology domain, CH-domain0.0008642Direct
alpha-catenin/vinculin-like0.001635Inherited
Notch domain0.001692Inherited
Calcium ATPase, transduction domain A0.002914Inherited
Myosin rod fragments0.003432Inherited
Calcium ATPase, transmembrane domain M0.006067Inherited
SRF-like0.006977Inherited
Flavoproteins0.01383Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.01623Inherited
Homeodomain-like0.01758Inherited
HLH, helix-loop-helix DNA-binding domain0.0199Inherited
Cystine-knot cytokines0.02854Inherited
TIMP-like0.05664Inherited
Spermadhesin, CUB domain0.06674Inherited
Inhibitor of apoptosis (IAP) repeat0.06677Inherited
E set domains0.06858Inherited
Voltage-gated potassium channels0.07465Inherited
Transducin (alpha subunit), insertion domain0.08695Inherited
WW domain0.1095Inherited
Actin-like ATPase domain0.126Inherited
(Trans)glycosidases0.1431Inherited
Clavaminate synthase-like0.1615Inherited
BPTI-like0.1683Inherited
Nucleotide cyclase0.1822Inherited
Thyroglobulin type-1 domain0.1954Inherited
B-box zinc-binding domain0.2166Inherited
POZ domain0.3151Inherited
Kazal-type serine protease inhibitors0.3224Inherited
Lipocalins0.4358Inherited
Metalloproteases ("zincins"), catalytic domain0.4698Inherited
"Winged helix" DNA-binding domain0.5528Inherited
RING/U-box0.5925Inherited
L domain-like0.8364Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
Troponin T0Direct
Lamin A/C globular tail domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Protein kinases, catalytic subunit0.000003064Direct
Spectrin repeat0.00004014Direct
EGF-type module0.00004395Direct
Nuclear receptor0.00004685Direct
L domain0.00005998Direct
Meta-cation ATPase, catalytic domain P0.00008365Direct
Nuclear receptor ligand-binding domain0.0000992Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0002577Direct
TB module/8-cys domain0.0003129Direct
MIR domain0.0003129Direct
SMAD domain0.0003129Direct
SMAD MH1 domain0.0003129Direct
Calcium ATPase, transmembrane domain M0.0004454Direct
Calponin-homology domain, CH-domain0.0008687Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0009112Direct
Notch domain0.001251Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.001251Inherited
NADPH-cytochrome p450 reductase-like0.001251Inherited
Growth factor receptor domain0.001348Inherited
Calcium ATPase, transduction domain A0.002592Inherited
Myosin rod fragments0.002918Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.004694Inherited
SRF-like0.005307Inherited
Paired domain0.007196Inherited
Homeodomain0.008943Inherited
alpha-catenin/vinculin0.01653Inherited
Forkhead DNA-binding domain0.01845Inherited
Erythroid transcription factor GATA-10.02109Inherited
I set domains0.02336Inherited
HLH, helix-loop-helix DNA-binding domain0.02336Inherited
Tetramerization domain of potassium channels0.02351Inherited
Laminin-type module0.02351Inherited
Inhibitor of apoptosis (IAP) repeat0.03383Inherited
Plakin repeat0.03383Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.04484Inherited
Spermadhesin, CUB domain0.06585Inherited
Voltage-gated potassium channels0.06841Inherited
LIM domain0.0699Inherited
Transducin (alpha subunit), insertion domain0.07893Inherited
ZZ domain0.08596Inherited
Transforming growth factor (TGF)-beta0.09341Inherited
WW domain0.1062Inherited
Small Kunitz-type inhibitors & BPTI-like toxins0.1544Inherited
Adenylyl and guanylyl cyclase catalytic domain0.1737Inherited
Thyroglobulin type-1 domain0.1846Inherited
B-box zinc-binding domain0.2121Inherited
EF-hand modules in multidomain proteins0.2517Inherited
Ovomucoid domain III-like0.2872Inherited
Fatty acid binding protein-like0.3606Inherited
28-residue LRR0.4028Inherited
Phosphotyrosine-binding domain (PTB)0.5495Inherited
Ngr ectodomain-like0.9344Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Lamin A/C globular tail domain0Direct
Troponin coil-coiled subunits0Direct
Protein kinase-like (PK-like)0.00000005212Direct
Glucocorticoid receptor-like (DNA-binding domain)0.000002697Direct
EGF/Laminin0.000007141Direct
Nuclear receptor ligand-binding domain0.00004492Direct
p53-like transcription factors0.00005428Direct
Growth factor receptor domain0.0000725Direct
Spectrin repeat0.0001239Direct
IP3 receptor type 1 binding core, domain 20.0002022Direct
MIR domain0.0002182Direct
TB module/8-cys domain0.0002182Direct
SMAD MH1 domain0.0002182Direct
Riboflavin synthase domain-like0.0004607Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0.0004607Direct
Calponin-homology domain, CH-domain0.000468Direct
alpha-catenin/vinculin-like0.0009195Direct
TSP type-3 repeat0.0009535Direct
Notch domain0.0009535Direct
Calcium ATPase, transduction domain A0.001689Inherited
Myosin rod fragments0.002004Inherited
Calcium ATPase, transmembrane domain M0.003672Inherited
SRF-like0.004272Inherited
Flavoproteins0.008846Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.0105Inherited
Homeodomain-like0.01145Inherited
dsRNA-binding domain-like0.01253Inherited
HLH, helix-loop-helix DNA-binding domain0.01306Inherited
Cystine-knot cytokines0.01931Inherited
Plakin repeat0.02837Inherited
TIMP-like0.04052Inherited
Spermadhesin, CUB domain0.04858Inherited
Inhibitor of apoptosis (IAP) repeat0.0486Inherited
E set domains0.0501Inherited
Voltage-gated potassium channels0.0549Inherited
Transducin (alpha subunit), insertion domain0.06474Inherited
WW domain0.08363Inherited
Actin-like ATPase domain0.09774Inherited
(Trans)glycosidases0.1126Inherited
Clavaminate synthase-like0.1287Inherited
BPTI-like0.1346Inherited
Nucleotide cyclase0.1473Inherited
Thyroglobulin type-1 domain0.1592Inherited
B-box zinc-binding domain0.1787Inherited
Intermediate filament protein, coiled coil region0.2652Inherited
POZ domain0.2711Inherited
Kazal-type serine protease inhibitors0.2782Inherited
Lipocalins0.3885Inherited
Metalloproteases ("zincins"), catalytic domain0.4221Inherited
"Winged helix" DNA-binding domain0.5061Inherited
RING/U-box0.5466Inherited
Family A G protein-coupled receptor-like0.7336Inherited
L domain-like0.8044Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55486,49854
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 49854 - Spermadhesin, CUB domain
  • 0Direct
    49265,56112
  • 49265 - Fibronectin type III
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    100909,49899
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.00000752Direct
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.000007817Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.00004033Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.00004033Direct
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.00006347Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.00006437Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0001735Direct
    82109,82109
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 0.0002022Direct
    82109,100909
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0.0002022Direct
    47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0.0009195Direct
    48726,56112
  • 48726 - Immunoglobulin
  • 56112 - Protein kinase-like (PK-like)
  • 0.0009535Direct
    103647,49899
  • 103647 - TSP type-3 repeat
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.0009535Direct
    103647,103647
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 0.0009535Direct
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.001887Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.003274Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.003669Inherited
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.003669Inherited
    57184,57610
  • 57184 - Growth factor receptor domain
  • 57610 - Thyroglobulin type-1 domain
  • 0.003669Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.003669Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.004272Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.00779Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.0105Inherited
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0.01355Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.01355Inherited
    47473,57850
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.01355Inherited
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0.01469Inherited
    100895,100895
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 0.02837Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04921Inherited
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0.04921Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.2909Inherited
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.3248Inherited
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.3732Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    49854,49854,57196
  • 49854 - Spermadhesin, CUB domain
  • 49854 - Spermadhesin, CUB domain
  • 57196 - EGF/Laminin
  • 0Direct
    82109,100909,49899
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    48726,49265,56112
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57196,49854,57196
  • 57196 - EGF/Laminin
  • 49854 - Spermadhesin, CUB domain
  • 57196 - EGF/Laminin
  • 0Direct
    55486,49854,49854
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 49854 - Spermadhesin, CUB domain
  • 49854 - Spermadhesin, CUB domain
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.00004033Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.00004085Direct
    82109,82109,100909
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0.0002022Direct
    47220,47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0.0002022Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0002937Direct
    103647,103647,49899
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.0009535Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0009535Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.0009535Direct
    90257,90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.0009535Direct
    103647,103647,103647
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 0.0009535Direct
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.001961Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.001961Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.003669Inherited
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.003669Inherited
    48726,49265,48726
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.004272Inherited
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.0105Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.01059Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.01163Inherited
    47473,47473,57850
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.01355Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.01355Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.01932Inherited
    48726,49265,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.1053Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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