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Mammalian Phenotype (MP): homeostasis/metabolism phenotype

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
- 1:   abnormal homeostasis [MP:0001764] <27>(103|129) (113|73|31)
- 1:   abnormal metabolism [MP:0005266] <21>(26|21) (30|11|3)
- 1:   wounding [MP:0013027] <17>(0|0) (0|0|0)
- 1:   abnormal response to injury [MP:0005164] <10>(12|22) (17|11|7)
- 1:   abnormal physiological response to xenobiotic [MP:0008872] <3>(6|6) (9|2|0)
- 1:   amyloidosis [MP:0000604] <2>(3|5) (4|2|1)
- 1:   abnormal xenobiotic pharmacokinetics [MP:0008875] <1>(2|2) (2|1|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Synuclein0Direct
Cu,Zn superoxide dismutase-like0Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0Direct
ATP-dependent DNA ligase DNA-binding domain0Direct
Pseudouridine synthase0Direct
Anaphylotoxins (complement system)0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Flavoproteins0Direct
DNA-glycosylase0Direct
Metallothionein0Direct
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Notch domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
HMA, heavy metal-associated domain0Direct
GLA-domain0Direct
WGR domain-like0Direct
Riboflavin synthase domain-like0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
Transferrin receptor-like dimerisation domain0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
CoA-dependent acyltransferases0Direct
Lipoxigenase0Direct
Resistin0Direct
Radical SAM enzymes0Direct
Uracil-DNA glycosylase-like0Direct
p53 tetramerization domain0Direct
Ammonium transporter0Direct
FAS1 domain0Direct
Lamin A/C globular tail domain0Direct
Family A G protein-coupled receptor-like0.000009596Direct
Cytochrome P4500.0001483Direct
Protein kinase-like (PK-like)0.0006753Direct
Nuclear receptor ligand-binding domain0.0007304Direct
p53-like transcription factors0.0007832Direct
Hormone receptor domain0.001861Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.003873Inherited
ABC transporter transmembrane region0.004449Inherited
alpha/beta-Hydrolases0.01047Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.01481Inherited
Acyl-CoA dehydrogenase NM domain-like0.01481Inherited
Glycosyl hydrolase domain0.01481Inherited
4-helical cytokines0.01629Inherited
Aquaporin-like0.02073Inherited
Glycerol-3-phosphate (1)-acyltransferase0.02073Inherited
PLP-dependent transferases0.02199Inherited
PYP-like sensor domain (PAS domain)0.02351Inherited
SMAD MH1 domain0.02457Inherited
TNF receptor-like0.03158Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.03368Inherited
LDL receptor-like module0.03369Inherited
NAD(P)-binding Rossmann-fold domains0.03862Inherited
Transcription factor STAT-4 N-domain0.04048Inherited
Inhibitor of apoptosis (IAP) repeat0.04048Inherited
STAT0.04048Inherited
Lipocalins0.04055Inherited
SMAD/FHA domain0.04972Inherited
Phoshotransferase/anion transport protein0.05008Inherited
CBS-domain pair0.05115Inherited
(Trans)glycosidases0.05894Inherited
DEATH domain0.06007Inherited
MFS general substrate transporter0.06007Inherited
Calcium-dependent phosphotriesterase0.06597Inherited
KA1-like0.06597Inherited
Thioesterase/thiol ester dehydrase-isomerase0.06597Inherited
Bet v1-like0.06905Inherited
Insulin-like0.07576Inherited
DHS-like NAD/FAD-binding domain0.07576Inherited
FnI-like domain0.07792Inherited
Cystine-knot cytokines0.08359Inherited
Kringle-like0.0897Inherited
SNF-like0.09712Inherited
DNA polymerase beta, N-terminal domain-like0.1059Inherited
ACT-like0.1059Inherited
TSP type-3 repeat0.1059Inherited
Serum albumin-like0.1059Inherited
FAD-binding/transporter-associated domain-like0.1059Inherited
Nuclear receptor coactivator interlocking domain0.1059Inherited
Apolipoprotein A-I0.1059Inherited
Multidrug efflux transporter AcrB transmembrane domain0.1132Inherited
Clc chloride channel0.1132Inherited
Thioredoxin-like0.1217Inherited
Integrin domains0.1445Inherited
Calponin-homology domain, CH-domain0.1564Inherited
Transducin (alpha subunit), insertion domain0.157Inherited
CAD & PB1 domains0.157Inherited
Galactose mutarotase-like0.1664Inherited
Putative DNA-binding domain0.1664Inherited
Triple coiled coil domain of C-type lectins0.1681Inherited
Domain of poly(ADP-ribose) polymerase0.1681Inherited
Caspase-like0.1816Inherited
ClpP/crotonase0.2095Inherited
Clathrin adaptor appendage domain0.2095Inherited
C-type lectin-like0.2142Inherited
Toll/Interleukin receptor TIR domain0.2255Inherited
Ran binding protein zinc finger-like0.2284Inherited
Cation efflux protein transmembrane domain-like0.2398Inherited
GAT-like domain0.2398Inherited
E set domains0.2809Inherited
Heme-dependent peroxidases0.2853Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain0.2853Inherited
EGF/Laminin0.3175Inherited
Actin-like ATPase domain0.3201Inherited
TIMP-like0.3368Inherited
DNA repair protein MutS, domain III0.3415Inherited
GroEL equatorial domain-like0.3415Inherited
BRCT domain0.348Inherited
Periplasmic binding protein-like I0.3611Inherited
PLC-like phosphodiesterases0.3632Inherited
YWTD domain0.3632Inherited
Cytokine0.3674Inherited
SH2 domain0.4Inherited
Spectrin repeat0.4289Inherited
FAD/NAD(P)-binding domain0.4471Inherited
Alkaline phosphatase-like0.4703Inherited
Plakin repeat0.5058Inherited
Trypsin-like serine proteases0.536Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.5423Inherited
Growth factor receptor domain0.5428Inherited
HMG-box0.6303Inherited
ENTH/VHS domain0.6411Inherited
Carbonic anhydrase0.6423Inherited
PH domain-like0.7072Inherited
HLH, helix-loop-helix DNA-binding domain0.7435Inherited
Fibronectin type III0.7594Inherited
Thyroglobulin type-1 domain0.799Inherited
ADP-ribosylation0.799Inherited
Metallo-dependent hydrolases0.8234Inherited
Nucleic acid-binding proteins0.8286Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.8473Inherited
CCCH zinc finger0.883Inherited
Intermediate filament protein, coiled coil region0.8954Inherited
Cyclin-like0.9022Inherited
Plexin repeat0.9721Inherited
SH3-domain0.9778Inherited
Homeodomain-like0.9996Inherited
Immunoglobulin1Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited
Sema domain1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Serum paraoxonase/arylesterase 1, PON10Direct
HMA, heavy metal-associated domain0Direct
gamma-adaptin C-terminal appendage domain-like0Direct
Anaphylotoxins (complement system)0Direct
DNA ligase/mRNA capping enzyme postcatalytic domain0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
FAS1 domain0Direct
Retinoblastoma tumor suppressor domains0Direct
Animal lipoxigenases0Direct
Tissue inhibitor of metalloproteinases, TIMP0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Carboxylesterase0Direct
HCDH C-domain-like0Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0Direct
ATP-dependent DNA ligase catalytic domain0Direct
Lamin A/C globular tail domain0Direct
Apolipoprotein A-I0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
FolH catalytic domain-like0Direct
RUNT domain0Direct
p53 DNA-binding domain-like0Direct
DNA ligase0Direct
Inhibitor of apoptosis (IAP) repeat0Direct
Phenylalanine metabolism regulatory domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
Notch domain0Direct
p53 tetramerization domain0Direct
Oligoxyloglucan reducing end-specific cellobiohydrolase0Direct
BAFF receptor-like0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Ammonium transporter0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
GLA-domain0Direct
Interleukin-1 (IL-1)0Direct
Cu,Zn superoxide dismutase-like0Direct
Transferrin receptor-like dimerisation domain0Direct
Metallothionein0Direct
IP3 receptor type 1 binding core, domain 20Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0Direct
Cytidylyltransferase0Direct
Erythroid transcription factor GATA-10Direct
WGR domain0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Neurolysin-like0Direct
Sialidases (neuraminidases)0Direct
Neurotrophin0Direct
Chromo barrel domain0Direct
Resistin0Direct
Sir2 family of transcriptional regulators0Direct
Amylase, catalytic domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Synuclein0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
5' to 3' exonuclease catalytic domain0Direct
HIT (HINT, histidine triad) family of protein kinase-interacting proteins0Direct
NADPH-cytochrome p450 reductase-like0Direct
Choline/Carnitine O-acyltransferase0Direct
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0Direct
Multidomain cupredoxins0Direct
Rhodopsin-like0.00003625Direct
Cytochrome P4500.0001425Direct
Nuclear receptor ligand-binding domain0.0007276Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.001356Inherited
Short-chain cytokines0.001356Inherited
Hormone receptor domain0.001518Inherited
Nuclear receptor0.001527Inherited
ABC transporter ATPase domain-like0.00257Inherited
ABC transporter transmembrane region0.003356Inherited
GABA-aminotransferase-like0.01189Inherited
CBS-domain pair0.01739Inherited
Aquaporin-like0.01739Inherited
Platelet-derived growth factor-like0.02001Inherited
SMAD domain0.02001Inherited
SMAD MH1 domain0.02001Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.02964Inherited
LDL receptor-like module0.03201Inherited
STAT0.03318Inherited
Pancreatic lipase, N-terminal domain0.03318Inherited
L domain0.03318Inherited
Cytochrome b50.03318Inherited
Transcription factor STAT-4 N-domain0.03318Inherited
STAT DNA-binding domain0.03318Inherited
Fibronectin type II module0.04262Inherited
TNF receptor-like0.04311Inherited
EGF-type module0.04889Inherited
Lipoxigenase N-terminal domain0.05524Inherited
Fatty acid binding protein-like0.06183Inherited
Anion transport protein, cytoplasmic domain0.06566Inherited
Insulin-like0.06566Inherited
T-box0.07898Inherited
SNF-like0.08783Inherited
Long-chain cytokines0.08783Inherited
Serum albumin-like0.091Inherited
Thrombospondin C-terminal domain0.091Inherited
DNA polymerase beta, N-terminal domain-like0.091Inherited
Nuclear receptor coactivator interlocking domain0.091Inherited
TSP type-3 repeat0.091Inherited
CAD domain0.091Inherited
Caspase catalytic domain0.09586Inherited
Clc chloride channel0.1002Inherited
Meta-cation ATPase, catalytic domain P0.1085Inherited
DEATH domain, DD0.121Inherited
Integrin domains0.1393Inherited
Transducin (alpha subunit), insertion domain0.1463Inherited
Domain of poly(ADP-ribose) polymerase0.1479Inherited
Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A0.1479Inherited
beta-glycanases0.1479Inherited
Crotonase-like0.1479Inherited
GAT domain0.1479Inherited
Adenosine/AMP deaminase0.1479Inherited
Triple coiled coil domain of C-type lectins0.1479Inherited
Kinase associated domain 1, KA10.1479Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.1492Inherited
Pointed domain0.1492Inherited
Gelsolin-like0.1492Inherited
Pyrin domain, PYD0.1492Inherited
Calponin-homology domain, CH-domain0.1593Inherited
C-type lectin domain0.1599Inherited
Forkhead DNA-binding domain0.1634Inherited
Matrix metalloproteases, catalytic domain0.1874Inherited
Interferon regulatory factor0.1933Inherited
Kringle modules0.1953Inherited
PLC-like (P variant)0.1981Inherited
Hemopexin-like domain0.205Inherited
FHA domain0.205Inherited
Ran binding protein zinc finger-like0.2183Inherited
Acetyl-CoA synthetase-like0.2183Inherited
Noncollagenous (NC1) domain of collagen IV0.2201Inherited
Cation efflux protein transmembrane domain-like0.2201Inherited
E2F dimerization segment0.2201Inherited
Spectrin repeat0.2203Inherited
Myeloperoxidase-like0.2684Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain0.2684Inherited
Toll/Interleukin receptor TIR domain0.2725Inherited
Phosphotyrosine-binding domain (PTB)0.3014Inherited
Growth factor receptor domain0.3099Inherited
DNA repair protein MutS, domain III0.3198Inherited
Mammalian PLC0.3315Inherited
YWTD domain0.3539Inherited
Poly(ADP-ribose) polymerase, C-terminal domain0.3658Inherited
28-residue LRR0.3712Inherited
Penta-EF-hand proteins0.3973Inherited
Papain-like0.438Inherited
SH2 domain0.4415Inherited
Pleckstrin-homology domain (PH domain)0.4649Inherited
Plakin repeat0.4876Inherited
Chaperone J-domain0.5148Inherited
p120GAP domain-like0.5218Inherited
Enabled/VASP homology 1 domain (EVH1 domain)0.5218Inherited
Transforming growth factor (TGF)-beta0.5278Inherited
Caspase recruitment domain, CARD0.5479Inherited
Eukaryotic proteases0.6066Inherited
VHS domain0.6319Inherited
Arylsulfatase0.6328Inherited
Interferons/interleukin-10 (IL-10)0.6328Inherited
Carbonic anhydrase0.635Inherited
LIM domain0.6435Inherited
HMG-box0.6447Inherited
Actin/HSP700.7114Inherited
FYVE, a phosphatidylinositol-3-phosphate binding domain0.722Inherited
HLH, helix-loop-helix DNA-binding domain0.7825Inherited
PHD domain0.7843Inherited
Thyroglobulin type-1 domain0.7957Inherited
Fibronectin type III0.8118Inherited
G proteins0.862Inherited
CCCH zinc finger0.8792Inherited
Intermediate filament protein, coiled coil region0.9034Inherited
Cyclin0.9604Inherited
Plexin repeat0.9733Inherited
SH3-domain0.9894Inherited
Homeodomain0.9923Inherited
Sema domain1Inherited


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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Resistin0Direct
Uracil-DNA glycosylase-like0Direct
DNA-glycosylase0Direct
HMA, heavy metal-associated domain0Direct
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0Direct
GLA-domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
CoA-dependent acyltransferases0Direct
Notch domain0Direct
Lipoxigenase0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Riboflavin synthase domain-like0Direct
Metallothionein0Direct
Radical SAM enzymes0Direct
FAS1 domain0Direct
Pseudouridine synthase0Direct
Synuclein0Direct
Anaphylotoxins (complement system)0Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Ammonium transporter0Direct
Lamin A/C globular tail domain0Direct
WGR domain-like0Direct
Flavoproteins0Direct
Transferrin receptor-like dimerisation domain0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Cu,Zn superoxide dismutase-like0Direct
ATP-dependent DNA ligase DNA-binding domain0Direct
Family A G protein-coupled receptor-like0.000004198Direct
Cytochrome P4500.00007389Direct
Protein kinase-like (PK-like)0.000361Direct
Nuclear receptor ligand-binding domain0.0003918Direct
p53-like transcription factors0.0004215Direct
Hormone receptor domain0.001054Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.002279Inherited
ABC transporter transmembrane region0.002636Inherited
alpha/beta-Hydrolases0.006565Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.009518Inherited
Acyl-CoA dehydrogenase NM domain-like0.009518Inherited
Glycosyl hydrolase domain0.009518Inherited
4-helical cytokines0.01055Inherited
Glycerol-3-phosphate (1)-acyltransferase0.01365Inherited
Aquaporin-like0.01365Inherited
PLP-dependent transferases0.01455Inherited
PYP-like sensor domain (PAS domain)0.01565Inherited
SMAD MH1 domain0.01642Inherited
TNF receptor-like0.02158Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.0231Inherited
LDL receptor-like module0.02311Inherited
NAD(P)-binding Rossmann-fold domains0.02673Inherited
Transcription factor STAT-4 N-domain0.02815Inherited
STAT0.02815Inherited
Inhibitor of apoptosis (IAP) repeat0.02815Inherited
Lipocalins0.0282Inherited
SMAD/FHA domain0.03512Inherited
Phoshotransferase/anion transport protein0.03538Inherited
CBS-domain pair0.03617Inherited
(Trans)glycosidases0.04235Inherited
DEATH domain0.04328Inherited
MFS general substrate transporter0.04328Inherited
Calcium-dependent phosphotriesterase0.04797Inherited
KA1-like0.04797Inherited
Thioesterase/thiol ester dehydrase-isomerase0.04797Inherited
Bet v1-like0.05048Inherited
Insulin-like0.05577Inherited
DHS-like NAD/FAD-binding domain0.05577Inherited
FnI-like domain0.0574Inherited
Cystine-knot cytokines0.06196Inherited
Kringle-like0.06695Inherited
SNF-like0.07311Inherited
TSP type-3 repeat0.08047Inherited
Apolipoprotein A-I0.08047Inherited
Nuclear receptor coactivator interlocking domain0.08047Inherited
Serum albumin-like0.08047Inherited
FAD-binding/transporter-associated domain-like0.08047Inherited
ACT-like0.08047Inherited
DNA polymerase beta, N-terminal domain-like0.08047Inherited
Clc chloride channel0.08678Inherited
Multidrug efflux transporter AcrB transmembrane domain0.08678Inherited
Phospholipase A2, PLA20.08678Inherited
Thioredoxin-like0.09396Inherited
Integrin domains0.1138Inherited
Calponin-homology domain, CH-domain0.1244Inherited
Transducin (alpha subunit), insertion domain0.1249Inherited
CAD & PB1 domains0.1249Inherited
Putative DNA-binding domain0.133Inherited
Galactose mutarotase-like0.133Inherited
Triple coiled coil domain of C-type lectins0.1344Inherited
Domain of poly(ADP-ribose) polymerase0.1344Inherited
Caspase-like0.1467Inherited
ClpP/crotonase0.172Inherited
Clathrin adaptor appendage domain0.172Inherited
Hemopexin-like domain0.1738Inherited
C-type lectin-like0.1764Inherited
Toll/Interleukin receptor TIR domain0.1871Inherited
Acetyl-CoA synthetase-like0.1896Inherited
Ran binding protein zinc finger-like0.1896Inherited
GAT-like domain0.2003Inherited
Cation efflux protein transmembrane domain-like0.2003Inherited
E set domains0.2389Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain0.2429Inherited
Heme-dependent peroxidases0.2429Inherited
EGF/Laminin0.2735Inherited
t-snare proteins0.2749Inherited
Actin-like ATPase domain0.2761Inherited
Periplasmic binding protein-like II0.2918Inherited
TIMP-like0.2918Inherited
GroEL equatorial domain-like0.2964Inherited
DNA repair protein MutS, domain III0.2964Inherited
BRCT domain0.3027Inherited
Periplasmic binding protein-like I0.3154Inherited
YWTD domain0.3176Inherited
PLC-like phosphodiesterases0.3176Inherited
Cytokine0.3216Inherited
E2F-DP heterodimerization region0.338Inherited
SH2 domain0.3534Inherited
Spectrin repeat0.382Inherited
FAD/NAD(P)-binding domain0.3995Inherited
Alkaline phosphatase-like0.4225Inherited
Plakin repeat0.4582Inherited
Chaperone J-domain0.4596Inherited
Trypsin-like serine proteases0.4889Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.4955Inherited
Growth factor receptor domain0.4959Inherited
HMG-box0.5859Inherited
ENTH/VHS domain0.5971Inherited
Carbonic anhydrase0.5984Inherited
EF-hand0.6487Inherited
PH domain-like0.6668Inherited
HLH, helix-loop-helix DNA-binding domain0.7051Inherited
Fibronectin type III0.7216Inherited
TNF-like0.7517Inherited
Thyroglobulin type-1 domain0.7641Inherited
ADP-ribosylation0.7641Inherited
Metallo-dependent hydrolases0.7903Inherited
Nucleic acid-binding proteins0.7959Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.8159Inherited
CCCH zinc finger0.8547Inherited
Intermediate filament protein, coiled coil region0.8679Inherited
Cyclin-like0.8755Inherited
Plexin repeat0.9534Inherited
SH3-domain0.9603Inherited
Homeodomain-like0.9867Inherited
P-loop containing nucleoside triphosphate hydrolases0.9889Inherited
Sema domain0.9992Inherited
Immunoglobulin1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
46565,57938
  • 46565 - Chaperone J-domain
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 0Direct
    49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    52025,53187
  • 52025 - PA domain
  • 53187 - Zn-dependent exopeptidases
  • 0Direct
    48452,57850
  • 48452 - TPR-like
  • 57850 - RING/U-box
  • 0Direct
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    57184,82895
  • 57184 - Growth factor receptor domain
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    57424,50494
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    54637,54637
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    142921,47587
  • 142921 - WGR domain-like
  • 47587 - Domain of poly(ADP-ribose) polymerase
  • 0Direct
    56112,54427
  • 56112 - Protein kinase-like (PK-like)
  • 54427 - NTF2-like
  • 0Direct
    51735,50129
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 0Direct
    50729,57889
  • 50729 - PH domain-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    48403,50044
  • 48403 - Ankyrin repeat
  • 50044 - SH3-domain
  • 0Direct
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    55021,56534
  • 55021 - ACT-like
  • 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
  • 0Direct
    57938,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    53187,47672
  • 53187 - Zn-dependent exopeptidases
  • 47672 - Transferrin receptor-like dimerisation domain
  • 0Direct
    50729,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    53474,49723
  • 53474 - alpha/beta-Hydrolases
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    57196,50494
  • 57196 - EGF/Laminin
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    117018,56091
  • 117018 - ATP-dependent DNA ligase DNA-binding domain
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 0Direct
    52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    52058,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    82153,82153
  • 82153 - FAS1 domain
  • 82153 - FAS1 domain
  • 0Direct
    88723,47807
  • 88723 - PIN domain-like
  • 47807 - 5' to 3' exonuclease, C-terminal subdomain
  • 0Direct
    111418,81321
  • 111418 - Hormone receptor domain
  • 81321 - Family A G protein-coupled receptor-like
  • 0Direct
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0Direct
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.001793Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.002636Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.009518Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.009518Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.009518Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.01365Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0193Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.0231Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.02383Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.02815Inherited
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.02815Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.02815Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.02815Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.02815Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.02815Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.04797Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.0574Inherited
    103647,49899
  • 103647 - TSP type-3 repeat
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.08047Inherited
    48552,48552
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 0.08047Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.08047Inherited
    103647,103647
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 0.08047Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.08678Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.08678Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.133Inherited
    55753,82754
  • 55753 - Actin depolymerizing proteins
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.1344Inherited
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.1344Inherited
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.1344Inherited
    47587,56399
  • 47587 - Domain of poly(ADP-ribose) polymerase
  • 56399 - ADP-ribosylation
  • 0.1344Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.1592Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1696Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.172Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.172Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.1871Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.2003Inherited
    47769,47769
  • 47769 - SAM/Pointed domain
  • 47769 - SAM/Pointed domain
  • 0.2003Inherited
    48464,89009
  • 48464 - ENTH/VHS domain
  • 89009 - GAT-like domain
  • 0.2003Inherited
    81324,81324
  • 81324 - Voltage-gated potassium channels
  • 81324 - Voltage-gated potassium channels
  • 0.2429Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.2429Inherited
    90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.2429Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.2749Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.2957Inherited
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0.2964Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2964Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.3235Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.3295Inherited
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0.338Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.338Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.3655Inherited
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0.3859Inherited
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.3859Inherited
    57184,57610
  • 57184 - Growth factor receptor domain
  • 57610 - Thyroglobulin type-1 domain
  • 0.4582Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.476Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.5186Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.5899Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.6816Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.9967Inherited
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.9992Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    46565,57938,49493
  • 46565 - Chaperone J-domain
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    142921,47587,56399
  • 142921 - WGR domain-like
  • 47587 - Domain of poly(ADP-ribose) polymerase
  • 56399 - ADP-ribosylation
  • 0Direct
    50729,50156,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    50129,51735,50129
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 0Direct
    52025,53187,47672
  • 52025 - PA domain
  • 53187 - Zn-dependent exopeptidases
  • 47672 - Transferrin receptor-like dimerisation domain
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57938,49493,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    117018,56091,50249
  • 117018 - ATP-dependent DNA ligase DNA-binding domain
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    49503,49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0Direct
    52058,49265,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0Direct
    57184,52058,49265
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    57424,57424,50494
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.003046Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.02815Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.02815Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.02815Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.03617Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.04548Inherited
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.04797Inherited
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.04797Inherited
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.04797Inherited
    103647,103647,49899
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.08047Inherited
    103647,103647,103647
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 0.08047Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.08047Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.08129Inherited
    55753,55753,55753
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 0.133Inherited
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.1344Inherited
    82754,55753,55753
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 0.1344Inherited
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.2003Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.2003Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.227Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.2429Inherited
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.2964Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.2964Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.338Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.6662Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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