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Mammalian Phenotype (MP): respiratory system phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   respiratory system phenotype [MP:0005388] <2>(33|46) (36|29|15)
- 1:   abnormal respiratory system physiology [MP:0002133] <23>(15|21) (16|13|7)
- 1:   abnormal respiratory system morphology [MP:0002132] <12>(22|34) (27|22|13)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
Lamin A/C globular tail domain0Direct
p53-like transcription factors0.000005427Direct
Homeodomain-like0.00001281Direct
FnI-like domain0.00002243Direct
Protein kinase-like (PK-like)0.00005101Direct
4-helical cytokines0.0001312Direct
EGF/Laminin0.0001324Direct
Growth factor receptor domain0.001324Inherited
Notch domain0.001604Inherited
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.006694Inherited
L27 domain0.008331Inherited
Kringle-like0.009228Inherited
HLH, helix-loop-helix DNA-binding domain0.009841Inherited
Snake toxin-like0.01093Inherited
Flavoproteins0.01322Inherited
E2F-DP heterodimerization region0.01322Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.0235Inherited
Riboflavin synthase domain-like0.0235Inherited
PGBD-like0.02473Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.04683Inherited
Hemopexin-like domain0.0537Inherited
Family A G protein-coupled receptor-like0.06825Inherited
TNF receptor-like0.1006Inherited
Integrin domains0.1119Inherited
DEATH domain0.1189Inherited
Nuclear receptor ligand-binding domain0.1581Inherited
Toll/Interleukin receptor TIR domain0.1622Inherited
Voltage-gated potassium channels0.3489Inherited
Integrin alpha N-terminal domain0.46Inherited
Trypsin-like serine proteases0.8439Inherited
PH domain-like1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
Lamin A/C globular tail domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
RUNT domain0Direct
p53 DNA-binding domain-like0Direct
p53 tetramerization domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Homeodomain0.00000179Direct
Rel/Dorsal transcription factors, DNA-binding domain0.00001442Direct
Extracellular domain of cell surface receptors0.00001442Direct
VWC domain0.0000425Direct
Short-chain cytokines0.0000425Direct
Forkhead DNA-binding domain0.0000528Direct
L domain0.00005347Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.00011Direct
Protein kinases, catalytic subunit0.0001826Direct
Growth factor receptor domain0.0003887Direct
Cell cycle transcription factor e2f-dp0.000867Direct
Notch domain0.001158Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.001158Inherited
NADPH-cytochrome p450 reductase-like0.001158Inherited
EGF-type module0.002989Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.004369Inherited
E2F dimerization segment0.004402Inherited
Phenylalanine metabolism regulatory domain0.005009Inherited
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.005009Inherited
L27 domain0.006636Inherited
HLH, helix-loop-helix DNA-binding domain0.01106Inherited
Kringle modules0.01779Inherited
Erythroid transcription factor GATA-10.01982Inherited
MMP N-terminal domain0.02152Inherited
Matrix metalloproteases, catalytic domain0.02882Inherited
Interferons/interleukin-10 (IL-10)0.03252Inherited
TNF receptor-like0.03493Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.04191Inherited
Rhodopsin-like0.04826Inherited
Hemopexin-like domain0.0483Inherited
Integrin domains0.1051Inherited
Nuclear receptor0.1283Inherited
Toll/Interleukin receptor TIR domain0.1313Inherited
Nuclear receptor ligand-binding domain0.1576Inherited
DEATH domain, DD0.1619Inherited
LIM domain0.3288Inherited
Integrin alpha N-terminal domain0.3477Inherited
Eukaryotic proteases0.7885Inherited
Phosphotyrosine-binding domain (PTB)0.8219Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Lamin A/C globular tail domain0Direct
p53-like transcription factors0.000002318Direct
Homeodomain-like0.000005645Direct
FnI-like domain0.00001012Direct
Protein kinase-like (PK-like)0.00002397Direct
4-helical cytokines0.00006501Direct
EGF/Laminin0.00006568Direct
Growth factor receptor domain0.0007356Direct
Notch domain0.0009009Direct
FAS1 domain0.004091Inherited
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.004091Inherited
L27 domain0.005148Inherited
Kringle-like0.005734Inherited
HLH, helix-loop-helix DNA-binding domain0.006153Inherited
Snake toxin-like0.006878Inherited
E2F-DP heterodimerization region0.008422Inherited
Flavoproteins0.008422Inherited
Riboflavin synthase domain-like0.01564Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.01564Inherited
PGBD-like0.01653Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.03297Inherited
Hemopexin-like domain0.03815Inherited
Family A G protein-coupled receptor-like0.0498Inherited
TNF receptor-like0.07605Inherited
Integrin domains0.08567Inherited
DEATH domain0.09167Inherited
Nuclear receptor ligand-binding domain0.1259Inherited
Toll/Interleukin receptor TIR domain0.1294Inherited
Cyclin-like0.1945Inherited
"Winged helix" DNA-binding domain0.2076Inherited
Voltage-gated potassium channels0.3036Inherited
Integrin alpha N-terminal domain0.4122Inherited
Trypsin-like serine proteases0.8124Inherited
PH domain-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.000008946Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.00003713Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.00003713Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.002392Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.003344Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.003486Inherited
    55021,56534
  • 55021 - ACT-like
  • 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
  • 0.004091Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.004091Inherited
    82153,82153
  • 82153 - FAS1 domain
  • 82153 - FAS1 domain
  • 0.004091Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.006872Inherited
    101288,50156
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 0.008422Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.008422Inherited
    57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.008422Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.008478Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0117Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.0117Inherited
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.01301Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.01615Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.01653Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.02302Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.02394Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.02702Inherited
    52799,49562
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.02733Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.1377Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.2448Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.2448Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.6101Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.00003713Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0004241Direct
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.00181Inherited
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.003486Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.008422Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.009063Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.01301Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.01615Inherited
    57603,57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.02733Inherited
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.05827Inherited
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.1831Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.2181Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.2448Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.58Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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