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Mammalian Phenotype (MP): reproductive system phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   reproductive system phenotype [MP:0005389] <2>(37|56) (46|17|6)
- 1:   abnormal reproductive system morphology [MP:0002160] <12>(27|44) (36|14|6)
- 1:   abnormal reproductive system physiology [MP:0001919] <10>(21|37) (27|10|2)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
Fibrinogen coiled-coil and central regions0Direct
Nuclear receptor ligand-binding domain0.0000001677Direct
Cystine-knot cytokines0.0000001748Direct
Tudor/PWWP/MBT0.00008685Direct
SMAD MH1 domain0.0001334Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0002481Direct
Protein kinase-like (PK-like)0.005705Inherited
E2F-DP heterodimerization region0.006293Inherited
Cysteine-rich DNA binding domain, (DM domain)0.006293Inherited
4-helical cytokines0.0105Inherited
Bcl-2 inhibitors of programmed cell death0.01218Inherited
PAZ domain0.01513Inherited
The spindle assembly checkpoint protein mad20.01694Inherited
HMA, heavy metal-associated domain0.01694Inherited
Flavoproteins0.03744Inherited
Transcription factor STAT-4 N-domain0.03744Inherited
STAT0.03744Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.03822Inherited
Homeodomain-like0.05196Inherited
LDL receptor-like module0.1197Inherited
Alpha-macroglobulin receptor domain0.1341Inherited
PYP-like sensor domain (PAS domain)0.1921Inherited
Nucleic acid-binding proteins0.2031Inherited
Blood coagulation inhibitor (disintegrin)0.2216Inherited
Metalloproteases ("zincins"), catalytic domain0.2448Inherited
SMAD/FHA domain0.2515Inherited
EGF/Laminin0.2572Inherited
SAICAR synthase-like0.2703Inherited
Alkaline phosphatase-like0.2855Inherited
Terpenoid cyclases/Protein prenyltransferases0.2995Inherited
HMG-box0.3618Inherited
Fibronectin type III0.5306Inherited
L domain-like0.6475Inherited
BAR/IMD domain-like0.6526Inherited
Immunoglobulin1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Fibrinogen coiled-coil and central regions0Direct
PAS domain of steroid receptor coactivator 1A, NCo-A10Direct
Retinoblastoma tumor suppressor domains0Direct
p53 tetramerization domain0Direct
p53 DNA-binding domain-like0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Nuclear receptor ligand-binding domain0.0000001237Direct
Nuclear receptor0.0000008861Direct
Transforming growth factor (TGF)-beta0.000003292Direct
Tudor domain0.00001372Direct
SMAD domain0.00008211Direct
SMAD MH1 domain0.00008211Direct
E2F dimerization segment0.00108Inherited
Short-chain cytokines0.002722Inherited
DNA repair protein MutS, domain III0.003743Inherited
NADPH-cytochrome p450 reductase-like0.003743Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.003743Inherited
Gonadodropin/Follitropin0.003743Inherited
Insulin-like0.004094Inherited
Linker histone H1/H50.004094Inherited
L domain0.004442Inherited
Cysteine-rich DNA binding domain, (DM domain)0.004442Inherited
Extracellular domain of cell surface receptors0.008958Inherited
Bcl-2 inhibitors of programmed cell death0.008958Inherited
Protein kinases, catalytic subunit0.009223Inherited
PAZ domain0.01118Inherited
Neurotrophin0.01231Inherited
gamma-adaptin C-terminal appendage domain-like0.01231Inherited
The spindle assembly checkpoint protein mad20.01231Inherited
HMA, heavy metal-associated domain0.01231Inherited
PHD domain0.01237Inherited
Cell cycle transcription factor e2f-dp0.02203Inherited
STAT0.02865Inherited
Single strand DNA-binding domain, SSB0.02865Inherited
STAT DNA-binding domain0.02865Inherited
Transcription factor STAT-4 N-domain0.02865Inherited
Nuclear receptor coactivator interlocking domain0.03575Inherited
Long-chain cytokines0.0597Inherited
Astacin0.07028Inherited
Histone lysine methyltransferases0.07382Inherited
Homeodomain0.0797Inherited
LDL receptor-like module0.1045Inherited
Alpha-macroglobulin receptor domain0.1131Inherited
Complement components0.1131Inherited
Forkhead DNA-binding domain0.1625Inherited
Growth factor receptor domain0.1769Inherited
EGF-type module0.1978Inherited
Reprolysin-like0.198Inherited
Blood coagulation inhibitor (disintegrin)0.1988Inherited
ABC transporter ATPase domain-like0.2821Inherited
HMG-box0.3423Inherited
Fibronectin type III0.5322Inherited
Ngr ectodomain-like0.621Inherited
I set domains0.9053Inherited
Rhodopsin-like0.9869Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
Fibrinogen coiled-coil and central regions0Direct
Nuclear receptor ligand-binding domain0.00000006668Direct
Cystine-knot cytokines0.00000006965Direct
Tudor/PWWP/MBT0.00004168Direct
SMAD MH1 domain0.00006609Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0001266Direct
DNA repair protein MutS, domain III0.003265Inherited
Protein kinase-like (PK-like)0.003444Inherited
Insulin-like0.003492Inherited
E2F-DP heterodimerization region0.003826Inherited
Cysteine-rich DNA binding domain, (DM domain)0.003826Inherited
4-helical cytokines0.006589Inherited
Bcl-2 inhibitors of programmed cell death0.007726Inherited
PAZ domain0.009731Inherited
HMA, heavy metal-associated domain0.01101Inherited
The spindle assembly checkpoint protein mad20.01101Inherited
Transcription factor STAT-4 N-domain0.02587Inherited
STAT0.02587Inherited
Flavoproteins0.02587Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.02645Inherited
Nuclear receptor coactivator interlocking domain0.03268Inherited
Homeodomain-like0.03681Inherited
"Winged helix" DNA-binding domain0.04217Inherited
LDL receptor-like module0.09232Inherited
Alpha-macroglobulin receptor domain0.1049Inherited
Growth factor receptor domain0.1419Inherited
PYP-like sensor domain (PAS domain)0.1562Inherited
Nucleic acid-binding proteins0.1662Inherited
Blood coagulation inhibitor (disintegrin)0.1835Inherited
Metalloproteases ("zincins"), catalytic domain0.2051Inherited
SMAD/FHA domain0.2112Inherited
EGF/Laminin0.2165Inherited
SAICAR synthase-like0.2289Inherited
Ribonuclease H-like0.2298Inherited
dsRNA-binding domain-like0.2432Inherited
Alkaline phosphatase-like0.2432Inherited
Terpenoid cyclases/Protein prenyltransferases0.2563Inherited
HMG-box0.3162Inherited
Cytochrome P4500.4423Inherited
Fibronectin type III0.4835Inherited
L domain-like0.604Inherited
BAR/IMD domain-like0.6094Inherited
Family A G protein-coupled receptor-like0.9643Inherited
Immunoglobulin1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    52058,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0001329Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.003265Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.003826Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.003826Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.003826Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.02587Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.02587Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.02587Inherited
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.03268Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.05266Inherited
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0.1515Inherited
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0.1835Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.3287Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.4654Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9393Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,49265
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    52058,49265,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.003826Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.02587Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.02587Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.1707Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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