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Mammalian Phenotype (MP): abnormal circulating protein level

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
+ + 2:   abnormal homeostasis [MP:0001764] <27>(103|129) (113|73|31)
+ 1:   abnormal blood homeostasis [MP:0009642] <23>(63|82) (70|45|21)
+ 1:   abnormal protein level [MP:0008469] <15>(23|31) (25|13|3)
0:   abnormal circulating protein level [MP:0005416] <24>(18|25) (20|10|3)
- 1:   abnormal circulating enzyme level [MP:0001570] <15>(7|8) (10|3|0)
- 1:   abnormal circulating cytokine level [MP:0010210] <4>(10|17) (10|6|2)
- 1:   abnormal circulating transferrin level [MP:0011892] <3>(0|0) (0|0|0)
- 1:   abnormal circulating angiotensinogen level [MP:0006373] <2>(0|0) (0|0|0)
- 1:   abnormal circulating antithrombin level [MP:0012324] <2>(0|0) (0|0|0)
- 1:   abnormal circulating complement protein level [MP:0010215] <2>(0|0) (0|0|0)
- 1:   abnormal circulating factor VIII level [MP:0012327] <2>(0|0) (0|0|0)
- 1:   abnormal circulating ferritin level [MP:0011889] <2>(0|0) (0|0|0)
- 1:   abnormal circulating fibrinogen level [MP:0010213] <2>(0|0) (0|0|0)
- 1:   abnormal circulating fibronectin level [MP:0011912] <2>(0|0) (0|0|0)
- 1:   abnormal circulating prothrombin level [MP:0012221] <2>(0|0) (0|0|0)
- 1:   abnormal circulating serum albumin level [MP:0000199] <2>(0|0) (0|0|0)
- 1:   abnormal circulating thrombin level [MP:0013255] <2>(0|0) (0|0|0)
- 1:   abnormal circulating total protein level [MP:0011888] <2>(0|1) (0|0|0)
- 1:   abnormal glycosylated hemoglobin level [MP:0006351] <2>(0|0) (0|0|0)
- 1:   abnormal circulating apolipoprotein level [MP:0010332] <1>(0|0) (0|0|0)
- 1:   abnormal circulating C-reactive protein level [MP:0010212](0|0) (0|0|0)
- 1:   abnormal circulating retinol binding protein level [MP:0010216](0|0) (0|0|0)
- 1:   abnormal circulating serum amyloid protein level [MP:0010214](0|0) (0|0|0)
- 1:   decreased circulating ceruloplasmin level [MP:0012661](0|0) (0|0|0)
- 1:   decreased circulating haptoglobin level [MP:0012664](0|0) (0|0|0)
- 1:   hemoglobinemia [MP:0000332](0|0) (0|0|0)
- 1:   increased circulating ceruloplasmin level [MP:0012662](0|0) (0|0|0)
- 1:   increased circulating haptoglobin level [MP:0012666](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
DEATH domain0.000001223Direct
STAT0.00000812Direct
Transcription factor STAT-4 N-domain0.00000812Direct
Toll/Interleukin receptor TIR domain0.00002331Direct
C-type lectin-like0.00006726Direct
FAS1 domain0.002194Inherited
Fibronectin type III0.005549Inherited
4-helical cytokines0.008254Inherited
SH2 domain0.02245Inherited
Caspase-like0.03669Inherited
Flavoproteins0.07421Inherited
p53-like transcription factors0.09784Inherited
CCCH zinc finger0.1158Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.1382Inherited
Riboflavin synthase domain-like0.1382Inherited
E set domains0.2734Inherited
CAD & PB1 domains0.3294Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Cytochrome p450 reductase N-terminal domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
STAT DNA-binding domain0.000005122Direct
STAT0.000005122Direct
Transcription factor STAT-4 N-domain0.000005122Direct
Toll/Interleukin receptor TIR domain0.00003591Direct
Interleukin-1 (IL-1)0.0002434Direct
DEATH domain, DD0.0002861Direct
FAS1 domain0.001506Inherited
Notch domain0.00509Inherited
Fibronectin type III0.005678Inherited
28-residue LRR0.006701Inherited
Interferon regulatory factor0.008582Inherited
Interferons/interleukin-10 (IL-10)0.00916Inherited
SH2 domain0.01768Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.01981Inherited
NADPH-cytochrome p450 reductase-like0.01981Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.01981Inherited
Pyrin domain, PYD0.01981Inherited
Caspase catalytic domain0.02125Inherited
p120GAP domain-like0.06116Inherited
Long-chain cytokines0.0633Inherited
Caspase recruitment domain, CARD0.0786Inherited
CCCH zinc finger0.1002Inherited
Growth factor receptor domain0.2368Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
DEATH domain0.0000005009Direct
Transcription factor STAT-4 N-domain0.00000352Direct
STAT0.00000352Direct
Toll/Interleukin receptor TIR domain0.00001055Direct
C-type lectin-like0.00003197Direct
FAS1 domain0.00125Inherited
Fibronectin type III0.003339Inherited
Notch domain0.004288Inherited
4-helical cytokines0.005094Inherited
SH2 domain0.01488Inherited
Caspase-like0.02529Inherited
Glycosyl hydrolase domain0.05454Inherited
Flavoproteins0.05454Inherited
p53-like transcription factors0.07374Inherited
CCCH zinc finger0.08907Inherited
Riboflavin synthase domain-like0.1085Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.1085Inherited
E set domains0.2317Inherited
CAD & PB1 domains0.2849Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.00000352Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.00000352Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.00000352Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.0002283Direct
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.0008132Direct
    82153,82153
  • 82153 - FAS1 domain
  • 82153 - FAS1 domain
  • 0.00125Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04179Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.05454Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.1423Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.00000352Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.00000352Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)