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Mammalian Phenotype (MP): abnormal skeleton morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   skeleton phenotype [MP:0005390] <2>(46|63) (50|41|26)
0:   abnormal skeleton morphology [MP:0005508] <15>(41|59) (47|38|25)
- 1:   abnormal bone structure [MP:0003795] <17>(17|23) (22|14|6)
- 1:   abnormal cartilage morphology [MP:0000163] <14>(8|14) (11|7|2)
- 1:   abnormal skeleton development [MP:0002113] <13>(6|14) (6|5|2)
- 1:   abnormal joint morphology [MP:0002932] <12>(3|6) (4|3|0)
- 1:   abnormal ligament morphology [MP:0005504] <5>(2|2) (2|1|0)
- 1:   abnormal appendicular skeleton morphology [MP:0009250] <4>(12|17) (17|12|13)
- 1:   abnormal axial skeleton morphology [MP:0002114] <4>(24|40) (25|21|14)
- 1:   abnormal tendon morphology [MP:0005503] <3>(2|3) (3|0|0)
- 1:   increased skeletal tumor incidence [MP:0010280] <3>(0|0) (0|0|0)
- 1:   abnormal clitoral bone morphology [MP:0011849] <1>(0|0) (0|0|0)
- 1:   abnormal perichondrium morphology [MP:0006322] <1>(0|0) (0|0|0)
- 1:   ectopic bone [MP:0014167] <1>(0|0) (0|0|0)
- 1:   abnormal enthesis morphology [MP:0013941](0|0) (0|0|0)
- 1:   decreased skeletal tumor incidence [MP:0012426](0|0) (0|0|0)
- 1:   synostosis [MP:0000566](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
BTG domain-like0Direct
p53 tetramerization domain0Direct
p53-like transcription factors0.0000008367Direct
Growth factor receptor domain0.000001986Direct
FnI-like domain0.0007739Direct
(Trans)glycosidases0.003309Inherited
Homeodomain-like0.01296Inherited
TB module/8-cys domain0.01586Inherited
Hect, E3 ligase catalytic domain0.01656Inherited
SCOP hierarchy in SUPERFAMILY0.02295Inherited
Bromodomain0.02926Inherited
Transducin (alpha subunit), insertion domain0.04025Inherited
HMG-box0.06062Inherited
Clc chloride channel0.06677Inherited
TNF receptor-like0.07278Inherited
YWTD domain0.07616Inherited
Flavoproteins0.1378Inherited
4-helical cytokines0.1529Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.1836Inherited
Riboflavin synthase domain-like0.1836Inherited
PYP-like sensor domain (PAS domain)0.2003Inherited
Kazal-type serine protease inhibitors0.2003Inherited
Glycosyl hydrolase domain0.2479Inherited
HLH, helix-loop-helix DNA-binding domain0.2699Inherited
lambda repressor-like DNA-binding domains0.275Inherited
L domain-like0.4576Inherited
Cyclin-like0.4999Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.5222Inherited
Nuclear receptor ligand-binding domain0.5267Inherited
EGF/Laminin0.544Inherited
TSP-1 type 1 repeat0.6338Inherited
Spermadhesin, CUB domain0.6577Inherited
TIMP-like0.6821Inherited
Nicotinic receptor ligand binding domain-like0.6843Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.6843Inherited
Hemopexin-like domain0.734Inherited
Cystine-knot cytokines0.7428Inherited
PGBD-like0.7619Inherited
Metalloproteases ("zincins"), catalytic domain0.7752Inherited
GLA-domain0.8205Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
BTG domain-like0Direct
Retinoblastoma tumor suppressor domains0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
RUNT domain0Direct
p53 DNA-binding domain-like0Direct
Clathrin adaptor appendage, alpha and beta chain-specific domain0Direct
p53 tetramerization domain0Direct
Homeodomain0Direct
Alpha-adaptin ear subdomain-like0Direct
Growth factor receptor domain0.00004258Direct
VWC domain0.0004825Direct
Paired domain0.0004882Direct
Transforming growth factor (TGF)-beta0.0009364Direct
DIX domain0.001154Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.001537Inherited
T-box0.001764Inherited
Notch domain0.003946Inherited
Arylsulfatase0.004383Inherited
Hect, E3 ligase catalytic domain0.009075Inherited
TB module/8-cys domain0.0118Inherited
beta-glycanases0.01283Inherited
Cytochrome p450 reductase N-terminal domain-like0.01283Inherited
MBT repeat0.01358Inherited
TNF receptor-like0.01556Inherited
Fibroblast growth factors (FGF)0.01781Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.02126Inherited
Laminin G-like module0.02291Inherited
Bromodomain0.02372Inherited
Transducin (alpha subunit), insertion domain0.03193Inherited
Laminin-type module0.03325Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.03713Inherited
NADPH-cytochrome p450 reductase-like0.03713Inherited
HMG-box0.05163Inherited
Clc chloride channel0.05371Inherited
Forkhead DNA-binding domain0.05562Inherited
YWTD domain0.06297Inherited
Classic zinc finger, C2H20.06856Inherited
Neutral endopeptidase (neprilysin)0.1168Inherited
HLH, helix-loop-helix DNA-binding domain0.2113Inherited
Long-chain cytokines0.301Inherited
Ngr ectodomain-like0.3374Inherited
EF-hand modules in multidomain proteins0.4498Inherited
SAM (sterile alpha motif) domain0.4557Inherited
Nuclear receptor ligand-binding domain0.4624Inherited
Nuclear receptor0.4624Inherited
TSP-1 type 1 repeat0.5743Inherited
EGF-type module0.5813Inherited
Spermadhesin, CUB domain0.6003Inherited
DEATH domain, DD0.6543Inherited
Nicotinic receptor ligand binding domain-like0.6693Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.6693Inherited
Hemopexin-like domain0.6834Inherited
Matrix metalloproteases, catalytic domain0.7133Inherited
MMP N-terminal domain0.7133Inherited
Extracellular domain of cell surface receptors0.7451Inherited
G proteins0.7779Inherited
GLA-domain0.7784Inherited
Kringle modules0.9709Inherited
I set domains1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
BTG domain-like0Direct
p53-like transcription factors0.0000003403Direct
Growth factor receptor domain0.0000008201Direct
FnI-like domain0.0004165Direct
(Trans)glycosidases0.001931Inherited
Notch domain0.003422Inherited
Homeodomain-like0.008249Inherited
TB module/8-cys domain0.01025Inherited
Hect, E3 ligase catalytic domain0.01073Inherited
Frizzled cysteine-rich domain0.01435Inherited
Bromodomain0.01986Inherited
Alkaline phosphatase-like0.02012Inherited
Transducin (alpha subunit), insertion domain0.02797Inherited
HMG-box0.0437Inherited
Clc chloride channel0.0486Inherited
TNF receptor-like0.05344Inherited
YWTD domain0.0561Inherited
Flavoproteins0.108Inherited
beta-beta-alpha zinc fingers0.116Inherited
4-helical cytokines0.1212Inherited
Riboflavin synthase domain-like0.1485Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.1485Inherited
Kazal-type serine protease inhibitors0.1636Inherited
PYP-like sensor domain (PAS domain)0.1636Inherited
LDL receptor-like module0.1702Inherited
Glycosyl hydrolase domain0.2078Inherited
HLH, helix-loop-helix DNA-binding domain0.2284Inherited
lambda repressor-like DNA-binding domains0.2333Inherited
L domain-like0.4098Inherited
Cyclin-like0.4523Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.4748Inherited
Nuclear receptor ligand-binding domain0.4794Inherited
EGF/Laminin0.4973Inherited
TSP-1 type 1 repeat0.5895Inherited
Spermadhesin, CUB domain0.6147Inherited
TIMP-like0.6403Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.6426Inherited
Nicotinic receptor ligand binding domain-like0.6426Inherited
Hemopexin-like domain0.6951Inherited
Cystine-knot cytokines0.7044Inherited
PGBD-like0.7243Inherited
Metalloproteases ("zincins"), catalytic domain0.7385Inherited
GLA-domain0.7871Inherited
Kringle-like0.919Inherited
TNF-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57184,82895
  • 57184 - Growth factor receptor domain
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    49265,53300
  • 49265 - Fibronectin type III
  • 53300 - vWA-like
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.00003634Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.0009794Direct
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0009814Direct
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.001057Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.001268Inherited
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0.003422Inherited
    57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.004036Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.005616Inherited
    53300,49265
  • 53300 - vWA-like
  • 49265 - Fibronectin type III
  • 0.0114Inherited
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.0114Inherited
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.01192Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.01192Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.01192Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.02054Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.02054Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.02549Inherited
    47473,57850
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.0338Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0561Inherited
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0.0561Inherited
    48726,56436
  • 48726 - Immunoglobulin
  • 56436 - C-type lectin-like
  • 0.06661Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.101Inherited
    63748,63748
  • 63748 - Tudor/PWWP/MBT
  • 63748 - Tudor/PWWP/MBT
  • 0.1102Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.1282Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.2078Inherited
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0.2247Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.2627Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.3445Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.6426Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.7243Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.7871Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.8547Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.958Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    49265,49265,53300
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 53300 - vWA-like
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.000421Direct
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.0009794Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.002442Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.002442Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.003422Inherited
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.003422Inherited
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.004036Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.01025Inherited
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0.0114Inherited
    57603,57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.01192Inherited
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.01192Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.02587Inherited
    47473,47473,57850
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.0338Inherited
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.0338Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0486Inherited
    48726,56436,56436
  • 48726 - Immunoglobulin
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.06661Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.07688Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.7692Inherited
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.7871Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9208Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.9327Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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