SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Mammalian Phenotype (MP): abnormal enzyme/coenzyme activity

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   homeostasis/metabolism phenotype [MP:0005376] <7>(139|174) (149|96|44)
+ 1:   abnormal metabolism [MP:0005266] <21>(26|22) (30|11|3)
0:   abnormal enzyme/coenzyme activity [MP:0005584] <41>(8|6) (8|1|0)
- 1:   abnormal cholinesterase activity [MP:0020029] <4>(0|0) (0|0|0)
- 1:   abnormal peroxidase activity [MP:0012579] <4>(1|0) (1|0|0)
- 1:   abnormal beta-glucuronidase activity [MP:0020054] <3>(0|0) (0|0|0)
- 1:   abnormal triglyceride lipase activity [MP:0011580] <3>(1|0) (1|0|0)
- 1:   abnormal tyrosine 3-monooxygenase activity [MP:0020073] <3>(0|0) (0|0|0)
- 1:   abnormal 5-aminolevulinate synthase activity [MP:0012643] <2>(0|0) (0|0|0)
- 1:   abnormal alcohol dehydrogenase activity [MP:0020118] <2>(0|0) (0|0|0)
- 1:   abnormal aldehyde dehydrogenase activity [MP:0020015] <2>(0|0) (0|0|0)
- 1:   abnormal aldehyde oxidase activity [MP:0020026] <2>(0|0) (0|0|0)
- 1:   abnormal alkaline phosphatase activity [MP:0011583] <2>(0|0) (0|0|0)
- 1:   abnormal angiotensin I-converting enzyme activity [MP:0013254] <2>(1|1) (1|0|0)
- 1:   abnormal arylsulphatase activity [MP:0020012] <2>(0|0) (0|0|0)
- 1:   abnormal benz (alpha) pyrene hydroxylase activity [MP:0012640] <2>(0|0) (0|0|0)
- 1:   abnormal catechol O-methyltransferase activity [MP:0012584] <2>(0|0) (0|0|0)
- 1:   abnormal choline O-acetyltransferase activity [MP:0012589] <2>(0|0) (0|0|0)
- 1:   abnormal coumarin hydroxylase activity [MP:0020035] <2>(0|0) (0|0|0)
- 1:   abnormal creatine kinase activity [MP:0020307] <2>(0|0) (0|0|0)
- 1:   abnormal delta-aminolaevulinate dehydratase activity [MP:0020021] <2>(0|0) (0|0|0)
- 1:   abnormal glucokinase activity [MP:0011604] <2>(0|0) (0|0|0)
- 1:   abnormal glucose-6-phosphate dehydrogenase activity [MP:0020042] <2>(0|0) (0|0|0)
- 1:   abnormal glutamate decarboxylase activity [MP:0012594] <2>(0|0) (0|0|0)
- 1:   abnormal glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [MP:0011607] <2>(0|0) (0|0|0)
- 1:   abnormal hormone-sensitive lipase activity [MP:0011589] <2>(0|0) (0|0|0)
- 1:   abnormal hydroxymethylbilane synthase activity [MP:0020310] <2>(0|0) (0|0|0)
- 1:   abnormal hypoxanthine phosphoribosyltransferase activity [MP:0020060] <2>(0|0) (0|0|0)
- 1:   abnormal maltase activity [MP:0020048] <2>(0|0) (0|0|0)
- 1:   abnormal monoamine oxidase activity [MP:0012635] <2>(0|0) (0|0|0)
- 1:   abnormal nicotinamide N-methyltransferase activity [MP:0012597] <2>(0|0) (0|0|0)
- 1:   abnormal ornithine carbamoyltransferase activity [MP:0011586] <2>(0|0) (0|0|0)
- 1:   abnormal palmitoyl-(protein) hydrolase activity [MP:0020313] <2>(0|0) (0|0|0)
- 1:   abnormal phenylalanine decarboxylase activity [MP:0020018] <2>(0|0) (0|0|0)
- 1:   abnormal phosphatidylcholine-sterol O-acyltransferase activity [MP:0011598] <2>(0|0) (0|0|0)
- 1:   abnormal phospholipid transfer protein activity [MP:0012780] <2>(0|0) (0|0|0)
- 1:   abnormal procollagen-proline 4-dioxygenase activity [MP:0020051] <2>(0|0) (0|0|0)
- 1:   abnormal proline oxidase activity [MP:0020227] <2>(0|0) (0|0|0)
- 1:   abnormal purine-nucleoside phosphorylase activity [MP:0011595] <2>(0|0) (0|0|0)
- 1:   abnormal pyruvate kinase activity [MP:0020243] <2>(0|0) (0|0|0)
- 1:   abnormal renin activity [MP:0005581] <2>(3|3) (3|0|0)
- 1:   abnormal thiopurine S-methyltransferase activity [MP:0020063] <2>(0|0) (0|0|0)
- 1:   abnormal tyrosine aminotransferase activity [MP:0020045] <2>(0|0) (0|0|0)
- 1:   abnormal urokinase activity [MP:0012646] <2>(0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
HMA, heavy metal-associated domain0.00002184Direct
Calcium-dependent phosphotriesterase0.0002121Direct
alpha/beta-Hydrolases0.1136Inherited
Thioredoxin-like0.2383Inherited
SH3-domain0.2906Inherited
Nuclear receptor ligand-binding domain0.8075Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.9361Inherited
Family A G protein-coupled receptor-like0.9821Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
HMA, heavy metal-associated domain0.00001149Direct
Growth factor receptor domain0.0008288Direct
SH3-domain0.2587Inherited
Nuclear receptor0.7653Inherited
Nuclear receptor ligand-binding domain0.7653Inherited
Rhodopsin-like0.8721Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
HMA, heavy metal-associated domain0.000009774Direct
Calcium-dependent phosphotriesterase0.0001071Direct
alpha/beta-Hydrolases0.08719Inherited
Thioredoxin-like0.1992Inherited
SH3-domain0.2482Inherited
Nuclear receptor ligand-binding domain0.7731Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.9131Inherited
Family A G protein-coupled receptor-like0.9655Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57184,57610
  • 57184 - Growth factor receptor domain
  • 57610 - Thyroglobulin type-1 domain
  • 0.0001071Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)