SUPERFAMILY 1.75 HMM library and genome assignments server

Mammalian Phenotype (MP): abnormal enzyme/coenzyme activity

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <30>
+ + 2:   homeostasis/metabolism phenotype [MP:0005376] <7>(133|157) (140|83|35)
+ 1:   abnormal metabolism [MP:0005266] <18>(23|20) (23|9|2)
0:   abnormal enzyme/coenzyme activity [MP:0005584] <38>(5|4) (6|0|0)
- 1:   abnormal cholinesterase activity [MP:0020029] <4>(0|0) (0|0|0)
- 1:   abnormal peroxidase activity [MP:0012579] <4>(1|0) (1|0|0)
- 1:   abnormal beta-glucuronidase activity [MP:0020054] <3>(0|0) (0|0|0)
- 1:   abnormal triglyceride lipase activity [MP:0011580] <3>(1|0) (1|0|0)
- 1:   abnormal tyrosine 3-monooxygenase activity [MP:0020073] <3>(0|0) (0|0|0)
- 1:   abnormal 5-aminolevulinate synthase activity [MP:0012643] <2>(0|0) (0|0|0)
- 1:   abnormal alcohol dehydrogenase activity [MP:0020118] <2>(0|0) (0|0|0)
- 1:   abnormal aldehyde dehydrogenase activity [MP:0020015] <2>(0|0) (0|0|0)
- 1:   abnormal aldehyde oxidase activity [MP:0020026] <2>(0|0) (0|0|0)
- 1:   abnormal alkaline phosphatase activity [MP:0011583] <2>(0|0) (0|0|0)
- 1:   abnormal angiotensin I-converting enzyme activity [MP:0013254] <2>(1|1) (1|0|0)
- 1:   abnormal arylsulphatase activity [MP:0020012] <2>(0|0) (0|0|0)
- 1:   abnormal benz (alpha) pyrene hydroxylase activity [MP:0012640] <2>(0|0) (0|0|0)
- 1:   abnormal catechol O-methyltransferase activity [MP:0012584] <2>(0|0) (0|0|0)
- 1:   abnormal choline O-acetyltransferase activity [MP:0012589] <2>(0|0) (0|0|0)
- 1:   abnormal coumarin hydroxylase activity [MP:0020035] <2>(0|0) (0|0|0)
- 1:   abnormal delta-aminolaevulinate dehydratase activity [MP:0020021] <2>(0|0) (0|0|0)
- 1:   abnormal glucokinase activity [MP:0011604] <2>(0|0) (0|0|0)
- 1:   abnormal glucose-6-phosphate dehydrogenase activity [MP:0020042] <2>(0|0) (0|0|0)
- 1:   abnormal glutamate decarboxylase activity [MP:0012594] <2>(0|0) (0|0|0)
- 1:   abnormal glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [MP:0011607] <2>(0|0) (0|0|0)
- 1:   abnormal hormone-sensitive lipase activity [MP:0011589] <2>(0|0) (0|0|0)
- 1:   abnormal hypoxanthine phosphoribosyltransferase activity [MP:0020060] <2>(0|0) (0|0|0)
- 1:   abnormal maltase activity [MP:0020048] <2>(0|0) (0|0|0)
- 1:   abnormal monoamine oxidase activity [MP:0012635] <2>(0|0) (0|0|0)
- 1:   abnormal nicotinamide N-methyltransferase activity [MP:0012597] <2>(0|0) (0|0|0)
- 1:   abnormal ornithine carbamoyltransferase activity [MP:0011586] <2>(0|0) (0|0|0)
- 1:   abnormal phenylalanine decarboxylase activity [MP:0020018] <2>(0|0) (0|0|0)
- 1:   abnormal phosphatidylcholine-sterol O-acyltransferase activity [MP:0011598] <2>(0|0) (0|0|0)
- 1:   abnormal phospholipid transfer protein activity [MP:0012780] <2>(0|0) (0|0|0)
- 1:   abnormal procollagen-proline 4-dioxygenase activity [MP:0020051] <2>(0|0) (0|0|0)
- 1:   abnormal proline oxidase activity [MP:0020227] <2>(0|0) (0|0|0)
- 1:   abnormal purine-nucleoside phosphorylase activity [MP:0011595] <2>(0|0) (0|0|0)
- 1:   abnormal pyruvate kinase activity [MP:0020243] <2>(0|0) (0|0|0)
- 1:   abnormal renin activity [MP:0005581] <2>(2|3) (3|0|0)
- 1:   abnormal thiopurine S-methyltransferase activity [MP:0020063] <2>(0|0) (0|0|0)
- 1:   abnormal tyrosine aminotransferase activity [MP:0020045] <2>(0|0) (0|0|0)
- 1:   abnormal urokinase activity [MP:0012646] <2>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
alpha/beta-Hydrolases0.1248Inherited
Thioredoxin-like0.2375Inherited
SH3-domain0.3448Inherited
Nuclear receptor ligand-binding domain0.6785Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.9Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
SH3-domain0.308Inherited
Nuclear receptor ligand-binding domain0.6288Inherited
Nuclear receptor0.6288Inherited
Rhodopsin-like0.8954Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
alpha/beta-Hydrolases0.09808Inherited
Thioredoxin-like0.1997Inherited
SH3-domain0.3002Inherited
Nuclear receptor ligand-binding domain0.6345Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.8697Inherited
Family A G protein-coupled receptor-like0.9695Inherited


Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
Plot tree as:   Download Newick format tree:
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