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Mammalian Phenotype (MP): abnormal leukocyte morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + 3:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + 2:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(58|86) (66|47|21)
+ + 2:   abnormal immune system morphology [MP:0000685] <3>(50|76) (60|35|18)
+ 1:   abnormal immune system cell morphology [MP:0000716] <5>(37|62) (48|29|16)
+ 1:   abnormal hematopoietic cell morphology [MP:0013656] <9>(49|76) (60|43|18)
0:   abnormal leukocyte morphology [MP:0008246] <4>(36|61) (47|29|15)
- 1:   abnormal leukocyte cell number [MP:0000217] <8>(29|48) (37|25|12)
- 1:   abnormal dendritic cell morphology [MP:0005461] <4>(2|4) (2|1|0)
- 1:   abnormal mononuclear cell morphology [MP:0008247] <2>(33|56) (41|28|14)
- 1:   abnormal myeloid leukocyte morphology [MP:0008250] <2>(11|24) (16|10|2)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
PsbU/PolX domain-like0Direct
Transcription factor STAT-4 N-domain0Direct
STAT0Direct
SPOC domain-like0Direct
TNF receptor-like0.000000009781Direct
p53-like transcription factors0.0002372Direct
DEATH domain0.002099Inherited
L30e-like0.002305Inherited
SH2 domain0.002412Inherited
DNA polymerase beta, N-terminal domain-like0.005752Inherited
Flavoproteins0.006714Inherited
Toll/Interleukin receptor TIR domain0.01204Inherited
Terpenoid cyclases/Protein prenyltransferases0.01307Inherited
Triple coiled coil domain of C-type lectins0.01765Inherited
Ran binding protein zinc finger-like0.02044Inherited
Bcl-2 inhibitors of programmed cell death0.03057Inherited
E2F-DP heterodimerization region0.03933Inherited
SET domain0.1147Inherited
BRCT domain0.1357Inherited
Nuclear receptor ligand-binding domain0.216Inherited
TIMP-like0.2254Inherited
DNA/RNA polymerases0.2313Inherited
Cysteine-rich domain0.2722Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.3158Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.3676Inherited
Riboflavin synthase domain-like0.3676Inherited
Integrin alpha N-terminal domain0.4099Inherited
Integrin domains0.4204Inherited
DBL homology domain (DH-domain)0.4204Inherited
Nucleotidyltransferase0.4427Inherited
Calponin-homology domain, CH-domain0.4984Inherited
MHC antigen-recognition domain0.5133Inherited
SMAD/FHA domain0.5133Inherited
WWE domain0.5239Inherited
SH3-domain0.5699Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
STAT0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
RUNT domain0Direct
DNA polymerase beta-like, second domain0Direct
Interleukin 17F, IL-17F0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
BAFF receptor-like0Direct
DNA polymerase beta-like0Direct
Proteasome subunits0Direct
Transcription factor STAT-4 N-domain0Direct
STAT DNA-binding domain0Direct
TNF receptor-like0.00000005716Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0001491Direct
Pyrin domain, PYD0.0003316Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.001139Inherited
SH2 domain0.001474Inherited
DEATH domain, DD0.002335Inherited
ets domain0.002854Inherited
DNA polymerase beta, N-terminal domain-like0.003968Inherited
Interleukin-1 (IL-1)0.003968Inherited
Pointed domain0.004742Inherited
Tissue inhibitor of metalloproteinases, TIMP0.01288Inherited
Triple coiled coil domain of C-type lectins0.01288Inherited
Cytochrome p450 reductase N-terminal domain-like0.01288Inherited
E2F dimerization segment0.01365Inherited
Ran binding protein zinc finger-like0.01567Inherited
Toll/Interleukin receptor TIR domain0.01797Inherited
Bcl-2 inhibitors of programmed cell death0.02339Inherited
Interferon regulatory factor0.02339Inherited
Nuclear receptor coactivator interlocking domain0.03725Inherited
Tetraspanin0.03725Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.03725Inherited
NADPH-cytochrome p450 reductase-like0.03725Inherited
V set domains (antibody variable domain-like)0.0514Inherited
DNA polymerase I0.07297Inherited
Cell cycle transcription factor e2f-dp0.08435Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.1172Inherited
C1 set domains (antibody constant domain-like)0.1553Inherited
MATH domain0.1611Inherited
Nuclear receptor ligand-binding domain0.1822Inherited
Nuclear receptor0.1822Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.1912Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.2096Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.2162Inherited
Long-chain cytokines0.2767Inherited
Interferons/interleukin-10 (IL-10)0.2767Inherited
Short-chain cytokines0.3222Inherited
C2 set domains0.3338Inherited
DBL homology domain (DH-domain)0.3789Inherited
Integrin domains0.3789Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.4014Inherited
Caspase recruitment domain, CARD0.4016Inherited
FHA domain0.4464Inherited
MHC antigen-recognition domain0.4726Inherited
Calponin-homology domain, CH-domain0.4804Inherited
beta-glycanases0.4832Inherited
WWE domain0.4832Inherited
SH3-domain0.5292Inherited
Pleckstrin-homology domain (PH domain)0.5585Inherited
Myb/SANT domain0.6911Inherited
PLC-like (P variant)0.7003Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SPOC domain-like0Direct
Transcription factor STAT-4 N-domain0Direct
STAT0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
PsbU/PolX domain-like0Direct
TNF receptor-like0.000000003696Direct
p53-like transcription factors0.0001203Direct
DEATH domain0.001196Inherited
L30e-like0.001317Inherited
SH2 domain0.001383Inherited
DNA polymerase beta, N-terminal domain-like0.00347Inherited
Flavoproteins0.004104Inherited
Immunoglobulin0.005278Inherited
Toll/Interleukin receptor TIR domain0.007628Inherited
Terpenoid cyclases/Protein prenyltransferases0.00832Inherited
Triple coiled coil domain of C-type lectins0.01149Inherited
Ran binding protein zinc finger-like0.01345Inherited
NAD kinase/diacylglycerol kinase-like0.0155Inherited
Bcl-2 inhibitors of programmed cell death0.02084Inherited
E2F-DP heterodimerization region0.02724Inherited
Nuclear receptor coactivator interlocking domain0.03414Inherited
TNF-like0.04908Inherited
SET domain0.08809Inherited
BRCT domain0.1063Inherited
Nuclear receptor ligand-binding domain0.1782Inherited
TIMP-like0.187Inherited
DNA/RNA polymerases0.1924Inherited
C-type lectin-like0.1935Inherited
Cysteine-rich domain0.2305Inherited
(Trans)glycosidases0.2371Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.2718Inherited
Riboflavin synthase domain-like0.3218Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.3218Inherited
CCCH zinc finger0.3278Inherited
Integrin alpha N-terminal domain0.3633Inherited
Integrin domains0.3735Inherited
DBL homology domain (DH-domain)0.3735Inherited
Protein kinase-like (PK-like)0.3851Inherited
Nucleotidyltransferase0.3952Inherited
Calponin-homology domain, CH-domain0.4507Inherited
SMAD/FHA domain0.4659Inherited
MHC antigen-recognition domain0.4659Inherited
WWE domain0.4764Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.479Inherited
SH3-domain0.5235Inherited
Acyl-CoA N-acyltransferases (Nat)0.7493Inherited
beta-beta-alpha zinc fingers0.7822Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0000002591Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0001206Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0006091Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.0009971Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0009971Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.001317Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.00378Inherited
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0.01149Inherited
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.01149Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.02724Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.04754Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.06859Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.09499Inherited
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.1571Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.2746Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.3735Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.3952Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.3952Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.3952Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.4164Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.4164Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.7032Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.002502Inherited
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.01149Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.1657Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.2051Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.3952Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.3952Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.4164Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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