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Mammalian Phenotype (MP): abnormal blood homeostasis

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
+ 1:   abnormal homeostasis [MP:0001764] <27>(103|129) (113|73|31)
0:   abnormal blood homeostasis [MP:0009642] <23>(63|82) (70|45|21)
- 1:   abnormal circulating hormone level [MP:0005418] <26>(24|23) (25|13|4)
- 1:   abnormal circulating protein level [MP:0005416] <24>(18|25) (20|10|3)
- 1:   abnormal circulating lipid level [MP:0003949] <9>(16|23) (19|13|10)
- 1:   abnormal circulating mineral level [MP:0006357] <8>(2|3) (2|1|0)
- 1:   abnormal circulating amino acid level [MP:0005311] <6>(7|8) (8|2|0)
- 1:   abnormal circulating lipoprotein level [MP:0010330] <4>(7|7) (7|4|3)
- 1:   abnormal circulating glucose level [MP:0000188] <3>(6|11) (6|7|3)
- 1:   abnormal blood osmolality [MP:0008996] <2>(5|5) (5|0|0)
- 1:   abnormal blood oxygen capacity [MP:0011235] <2>(0|0) (0|0|0)
- 1:   abnormal blood pH regulation [MP:0003027] <2>(0|0) (0|0|0)
- 1:   abnormal blood urea nitrogen level [MP:0005265] <2>(4|6) (5|0|0)
- 1:   abnormal blood uric acid level [MP:0008820] <2>(0|0) (0|0|0)
- 1:   abnormal circulating bicarbonate level [MP:0003015] <2>(1|1) (1|0|0)
- 1:   abnormal circulating bilirubin level [MP:0001569] <2>(0|0) (0|0|0)
- 1:   abnormal circulating fructosamine level [MP:0010086] <2>(0|0) (0|0|0)
- 1:   abnormal circulating ketone body level [MP:0003457] <2>(1|0) (1|1|0)
- 1:   abnormal circulating lactate level [MP:0013403] <2>(0|0) (0|0|0)
- 1:   uremia [MP:0009644] <2>(4|6) (5|1|0)
- 1:   abnormal blood gas level [MP:0002329] <1>(0|0) (0|0|0)
- 1:   abnormal circulating ammonia level [MP:0005308] <1>(0|0) (0|0|0)
- 1:   abnormal hemostasis [MP:0009676] <1>(13|16) (15|12|5)
- 1:   abnormal circulating hyaluronic acid level [MP:0020341](0|0) (0|0|0)
- 1:   cyanosis [MP:0001575](3|5) (4|2|2)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Lamin A/C globular tail domain0Direct
GLA-domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Ammonium transporter0Direct
Flavoproteins0.004372Inherited
STAT0.004372Inherited
Transcription factor STAT-4 N-domain0.004372Inherited
Insulin-like0.00751Inherited
KA1-like0.01032Inherited
Nuclear receptor coactivator interlocking domain0.0236Inherited
Apolipoprotein A-I0.0236Inherited
Serum albumin-like0.0236Inherited
Toll/Interleukin receptor TIR domain0.02693Inherited
4-helical cytokines0.02895Inherited
Clathrin adaptor appendage domain0.03733Inherited
GAT-like domain0.06643Inherited
Kringle-like0.0941Inherited
GroEL equatorial domain-like0.1273Inherited
YWTD domain0.1407Inherited
PLP-dependent transferases0.1467Inherited
Actin-like ATPase domain0.1786Inherited
PYP-like sensor domain (PAS domain)0.1842Inherited
C-type lectin-like0.1882Inherited
Heme-dependent peroxidases0.1942Inherited
Acyl-CoA dehydrogenase NM domain-like0.2104Inherited
CAD & PB1 domains0.2104Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.2104Inherited
SH2 domain0.2274Inherited
Growth factor receptor domain0.239Inherited
SMAD MH1 domain0.2564Inherited
PH domain-like0.3267Inherited
Hormone receptor domain0.3607Inherited
Transducin (alpha subunit), insertion domain0.3775Inherited
Multidrug efflux transporter AcrB transmembrane domain0.381Inherited
EGF/Laminin0.3878Inherited
Nuclear receptor ligand-binding domain0.4216Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.4382Inherited
FAS1 domain0.4652Inherited
Family A G protein-coupled receptor-like0.5004Inherited
CCCH zinc finger0.5029Inherited
Thyroglobulin type-1 domain0.5109Inherited
HLH, helix-loop-helix DNA-binding domain0.5111Inherited
Integrin domains0.575Inherited
alpha/beta-Hydrolases0.5911Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.6092Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.64Inherited
Riboflavin synthase domain-like0.64Inherited
Aquaporin-like0.64Inherited
Homeodomain-like0.6491Inherited
ClpP/crotonase0.6553Inherited
Caspase-like0.6553Inherited
PLC-like phosphodiesterases0.6553Inherited
ENTH/VHS domain0.699Inherited
Trypsin-like serine proteases0.7278Inherited
DEATH domain0.7743Inherited
Fibronectin type III0.7804Inherited
Cytochrome P4500.8332Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.8537Inherited
E set domains0.9037Inherited
Cystine-knot cytokines0.9103Inherited
Phoshotransferase/anion transport protein0.9661Inherited
Thioredoxin-like0.9744Inherited
p53-like transcription factors1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
gamma-adaptin C-terminal appendage domain-like0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
IP3 receptor type 1 binding core, domain 20Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Lamin A/C globular tail domain0Direct
Cytidylyltransferase0Direct
Apolipoprotein A-I0Direct
Multidomain cupredoxins0Direct
Ammonium transporter0Direct
Carboxylesterase0Direct
GLA-domain0Direct
NADPH-cytochrome p450 reductase-like0Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.00001042Direct
L domain0.003163Inherited
STAT DNA-binding domain0.003163Inherited
STAT0.003163Inherited
Transcription factor STAT-4 N-domain0.003163Inherited
Insulin-like0.005667Inherited
Serum albumin-like0.01812Inherited
Interleukin-1 (IL-1)0.01812Inherited
Nuclear receptor coactivator interlocking domain0.01812Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.02632Inherited
Interferon regulatory factor0.03004Inherited
Toll/Interleukin receptor TIR domain0.03704Inherited
GAT domain0.04178Inherited
Kinase associated domain 1, KA10.04178Inherited
Phosphotyrosine-binding domain (PTB)0.04689Inherited
Long-chain cytokines0.05185Inherited
Noncollagenous (NC1) domain of collagen IV0.0544Inherited
CAD domain0.1086Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.1153Inherited
YWTD domain0.1256Inherited
Myeloperoxidase-like0.1734Inherited
GABA-aminotransferase-like0.1784Inherited
Papain-like0.1926Inherited
SH2 domain0.197Inherited
SMAD domain0.2216Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.2216Inherited
SMAD MH1 domain0.2216Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.2216Inherited
Sir2 family of transcriptional regulators0.2216Inherited
Interferons/interleukin-10 (IL-10)0.2472Inherited
Kringle modules0.2502Inherited
Growth factor receptor domain0.2564Inherited
Pancreatic lipase, N-terminal domain0.2753Inherited
VHS domain0.283Inherited
Nuclear receptor0.3141Inherited
G proteins0.3177Inherited
DEATH domain, DD0.3239Inherited
Hormone receptor domain0.3239Inherited
p120GAP domain-like0.327Inherited
Transducin (alpha subunit), insertion domain0.34Inherited
Meta-cation ATPase, catalytic domain P0.34Inherited
Pyrin domain, PYD0.3431Inherited
Nuclear receptor ligand-binding domain0.3852Inherited
Transforming growth factor (TGF)-beta0.3889Inherited
Pleckstrin-homology domain (PH domain)0.4006Inherited
FAS1 domain0.4253Inherited
EGF-type module0.4568Inherited
CCCH zinc finger0.4846Inherited
Thyroglobulin type-1 domain0.4955Inherited
Rhodopsin-like0.516Inherited
HLH, helix-loop-helix DNA-binding domain0.5317Inherited
PLC-like (P variant)0.5361Inherited
Integrin domains0.538Inherited
Aquaporin-like0.6042Inherited
Caspase catalytic domain0.6202Inherited
Mammalian PLC0.6202Inherited
Homeodomain0.649Inherited
28-residue LRR0.671Inherited
Eukaryotic proteases0.6873Inherited
Notch domain0.7065Inherited
Caspase recruitment domain, CARD0.7389Inherited
Fibronectin type III0.8082Inherited
Cytochrome P4500.8089Inherited
Anion transport protein, cytoplasmic domain0.8708Inherited
ABC transporter ATPase domain-like0.8857Inherited
Fatty acid binding protein-like0.9124Inherited
Forkhead DNA-binding domain0.9176Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Lamin A/C globular tail domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
GLA-domain0Direct
Ammonium transporter0Direct
Flavoproteins0.002588Inherited
STAT0.002588Inherited
Transcription factor STAT-4 N-domain0.002588Inherited
Insulin-like0.004601Inherited
KA1-like0.006461Inherited
Apolipoprotein A-I0.01569Inherited
Serum albumin-like0.01569Inherited
Nuclear receptor coactivator interlocking domain0.01569Inherited
Toll/Interleukin receptor TIR domain0.0181Inherited
4-helical cytokines0.0196Inherited
Clathrin adaptor appendage domain0.02578Inherited
GAT-like domain0.04829Inherited
Kringle-like0.07056Inherited
GroEL equatorial domain-like0.09884Inherited
YWTD domain0.1105Inherited
PLP-dependent transferases0.1158Inherited
Actin-like ATPase domain0.1438Inherited
PYP-like sensor domain (PAS domain)0.149Inherited
C-type lectin-like0.1525Inherited
Heme-dependent peroxidases0.158Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.1728Inherited
Acyl-CoA dehydrogenase NM domain-like0.1728Inherited
CAD & PB1 domains0.1728Inherited
SH2 domain0.1887Inherited
FnI-like domain0.1991Inherited
Growth factor receptor domain0.1996Inherited
SMAD MH1 domain0.2157Inherited
DHS-like NAD/FAD-binding domain0.2157Inherited
Glycosyl hydrolase domain0.2157Inherited
t-snare proteins0.2687Inherited
PH domain-like0.2823Inherited
Hormone receptor domain0.315Inherited
Transducin (alpha subunit), insertion domain0.3314Inherited
Multidrug efflux transporter AcrB transmembrane domain0.3348Inherited
EGF/Laminin0.3414Inherited
Nuclear receptor ligand-binding domain0.3747Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.3907Inherited
FAS1 domain0.4174Inherited
Family A G protein-coupled receptor-like0.4528Inherited
CCCH zinc finger0.4552Inherited
Thyroglobulin type-1 domain0.4635Inherited
HLH, helix-loop-helix DNA-binding domain0.4637Inherited
Integrin domains0.5286Inherited
alpha/beta-Hydrolases0.545Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.5638Inherited
Riboflavin synthase domain-like0.5958Inherited
Aquaporin-like0.5958Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.5958Inherited
Homeodomain-like0.6056Inherited
PLC-like phosphodiesterases0.6121Inherited
Caspase-like0.6121Inherited
ClpP/crotonase0.6121Inherited
ENTH/VHS domain0.658Inherited
Trypsin-like serine proteases0.6885Inherited
Notch domain0.6993Inherited
DEATH domain0.7375Inherited
Fibronectin type III0.7442Inherited
Cytochrome P4500.8009Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.8227Inherited
E set domains0.8772Inherited
Cystine-knot cytokines0.8844Inherited
P-loop containing nucleoside triphosphate hydrolases0.9Inherited
Phoshotransferase/anion transport protein0.9467Inherited
Thioredoxin-like0.9563Inherited
Lipocalins0.989Inherited
p53-like transcription factors1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,50494
  • 57196 - EGF/Laminin
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    52058,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.0003949Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.002588Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.002588Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.002588Inherited
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.002588Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.002588Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.002588Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.01038Inherited
    48552,48552
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 0.01569Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.02279Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.02578Inherited
    47769,47769
  • 47769 - SAM/Pointed domain
  • 47769 - SAM/Pointed domain
  • 0.04829Inherited
    48464,89009
  • 48464 - ENTH/VHS domain
  • 89009 - GAT-like domain
  • 0.04829Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.05617Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.08053Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.09068Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1386Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.158Inherited
    111418,81321
  • 111418 - Hormone receptor domain
  • 81321 - Family A G protein-coupled receptor-like
  • 0.1667Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.1728Inherited
    57184,57610
  • 57184 - Growth factor receptor domain
  • 57610 - Thyroglobulin type-1 domain
  • 0.1767Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.1959Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.2157Inherited
    53474,49723
  • 53474 - alpha/beta-Hydrolases
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 0.3348Inherited
    90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.3348Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.3348Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.3462Inherited
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.3798Inherited
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0.3798Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.4112Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.4134Inherited
    82153,82153
  • 82153 - FAS1 domain
  • 82153 - FAS1 domain
  • 0.4174Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.4174Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.4339Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.4697Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.6993Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    52058,49265,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    49503,49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    57184,52058,49265
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.002588Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.002588Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.002588Inherited
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.006461Inherited
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.006461Inherited
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.006461Inherited
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.03743Inherited
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.04829Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.05084Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.08865Inherited
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.09884Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.3314Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.4552Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.4697Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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