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Mammalian Phenotype (MP): abnormal blood homeostasis

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
+ 1:   abnormal homeostasis [MP:0001764] <27>(103|129) (113|73|31)
0:   abnormal blood homeostasis [MP:0009642] <23>(63|82) (70|45|21)
- 1:   abnormal circulating hormone level [MP:0005418] <26>(24|23) (25|13|4)
- 1:   abnormal circulating protein level [MP:0005416] <24>(18|25) (20|10|3)
- 1:   abnormal circulating lipid level [MP:0003949] <9>(16|23) (19|13|10)
- 1:   abnormal circulating mineral level [MP:0006357] <8>(2|3) (2|1|0)
- 1:   abnormal circulating amino acid level [MP:0005311] <6>(7|8) (8|2|0)
- 1:   abnormal circulating lipoprotein level [MP:0010330] <4>(7|7) (7|4|3)
- 1:   abnormal circulating glucose level [MP:0000188] <3>(6|11) (6|7|3)
- 1:   abnormal blood osmolality [MP:0008996] <2>(5|5) (5|0|0)
- 1:   abnormal blood oxygen capacity [MP:0011235] <2>(0|0) (0|0|0)
- 1:   abnormal blood pH regulation [MP:0003027] <2>(0|0) (0|0|0)
- 1:   abnormal blood urea nitrogen level [MP:0005265] <2>(4|6) (5|0|0)
- 1:   abnormal blood uric acid level [MP:0008820] <2>(0|0) (0|0|0)
- 1:   abnormal circulating bicarbonate level [MP:0003015] <2>(1|1) (1|0|0)
- 1:   abnormal circulating bilirubin level [MP:0001569] <2>(0|0) (0|0|0)
- 1:   abnormal circulating fructosamine level [MP:0010086] <2>(0|0) (0|0|0)
- 1:   abnormal circulating ketone body level [MP:0003457] <2>(1|0) (1|1|0)
- 1:   abnormal circulating lactate level [MP:0013403] <2>(0|0) (0|0|0)
- 1:   uremia [MP:0009644] <2>(4|6) (5|1|0)
- 1:   abnormal blood gas level [MP:0002329] <1>(0|0) (0|0|0)
- 1:   abnormal circulating ammonia level [MP:0005308] <1>(0|0) (0|0|0)
- 1:   abnormal hemostasis [MP:0009676] <1>(13|16) (15|12|5)
- 1:   abnormal circulating hyaluronic acid level [MP:0020341](0|0) (0|0|0)
- 1:   cyanosis [MP:0001575](3|5) (4|2|2)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
GLA-domain0Direct
Ammonium transporter0Direct
Lamin A/C globular tail domain0Direct
Flavoproteins0.004381Inherited
Transcription factor STAT-4 N-domain0.004381Inherited
STAT0.004381Inherited
Insulin-like0.007514Inherited
KA1-like0.01034Inherited
Serum albumin-like0.02361Inherited
Nuclear receptor coactivator interlocking domain0.02361Inherited
Apolipoprotein A-I0.02361Inherited
Toll/Interleukin receptor TIR domain0.02697Inherited
4-helical cytokines0.02895Inherited
Clathrin adaptor appendage domain0.03738Inherited
GAT-like domain0.06647Inherited
Kringle-like0.09412Inherited
GroEL equatorial domain-like0.1274Inherited
YWTD domain0.1409Inherited
PLP-dependent transferases0.1468Inherited
Actin-like ATPase domain0.1788Inherited
PYP-like sensor domain (PAS domain)0.1842Inherited
C-type lectin-like0.1881Inherited
Heme-dependent peroxidases0.1943Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.2105Inherited
Acyl-CoA dehydrogenase NM domain-like0.2105Inherited
CAD & PB1 domains0.2105Inherited
SH2 domain0.2274Inherited
Growth factor receptor domain0.2395Inherited
SMAD MH1 domain0.2564Inherited
PH domain-like0.3267Inherited
Hormone receptor domain0.3607Inherited
Transducin (alpha subunit), insertion domain0.3775Inherited
Multidrug efflux transporter AcrB transmembrane domain0.381Inherited
EGF/Laminin0.388Inherited
Nuclear receptor ligand-binding domain0.4216Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.4382Inherited
FAS1 domain0.4652Inherited
Family A G protein-coupled receptor-like0.5004Inherited
CCCH zinc finger0.5032Inherited
Thyroglobulin type-1 domain0.5111Inherited
HLH, helix-loop-helix DNA-binding domain0.5118Inherited
Integrin domains0.5751Inherited
alpha/beta-Hydrolases0.591Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.6097Inherited
Aquaporin-like0.64Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.64Inherited
Riboflavin synthase domain-like0.64Inherited
Homeodomain-like0.6502Inherited
ClpP/crotonase0.6552Inherited
PLC-like phosphodiesterases0.6552Inherited
Caspase-like0.6552Inherited
ENTH/VHS domain0.6992Inherited
Trypsin-like serine proteases0.7281Inherited
DEATH domain0.7743Inherited
Fibronectin type III0.7811Inherited
Cytochrome P4500.8332Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.8537Inherited
E set domains0.9039Inherited
Cystine-knot cytokines0.9104Inherited
Phoshotransferase/anion transport protein0.9662Inherited
Thioredoxin-like0.9744Inherited
p53-like transcription factors1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
gamma-adaptin C-terminal appendage domain-like0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Carboxylesterase0Direct
Lamin A/C globular tail domain0Direct
Apolipoprotein A-I0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Ammonium transporter0Direct
GLA-domain0Direct
IP3 receptor type 1 binding core, domain 20Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0Direct
Cytidylyltransferase0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
NADPH-cytochrome p450 reductase-like0Direct
Multidomain cupredoxins0Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.00001046Direct
STAT0.003184Inherited
L domain0.003184Inherited
Transcription factor STAT-4 N-domain0.003184Inherited
STAT DNA-binding domain0.003184Inherited
Insulin-like0.005701Inherited
Serum albumin-like0.01818Inherited
Nuclear receptor coactivator interlocking domain0.01818Inherited
Interleukin-1 (IL-1)0.01818Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.02642Inherited
Interferon regulatory factor0.03015Inherited
Toll/Interleukin receptor TIR domain0.03719Inherited
GAT domain0.0419Inherited
Kinase associated domain 1, KA10.0419Inherited
Phosphotyrosine-binding domain (PTB)0.04696Inherited
Long-chain cytokines0.05202Inherited
Noncollagenous (NC1) domain of collagen IV0.05457Inherited
CAD domain0.1088Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.1155Inherited
YWTD domain0.1259Inherited
Myeloperoxidase-like0.1737Inherited
GABA-aminotransferase-like0.1786Inherited
Papain-like0.1929Inherited
SH2 domain0.1972Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.2217Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.2217Inherited
SMAD domain0.2217Inherited
SMAD MH1 domain0.2217Inherited
Sir2 family of transcriptional regulators0.2217Inherited
Interferons/interleukin-10 (IL-10)0.2476Inherited
Kringle modules0.2506Inherited
Growth factor receptor domain0.2566Inherited
Pancreatic lipase, N-terminal domain0.2755Inherited
VHS domain0.2833Inherited
Nuclear receptor0.3143Inherited
G proteins0.3188Inherited
DEATH domain, DD0.3241Inherited
Hormone receptor domain0.3241Inherited
p120GAP domain-like0.3273Inherited
Meta-cation ATPase, catalytic domain P0.3402Inherited
Transducin (alpha subunit), insertion domain0.3402Inherited
Pyrin domain, PYD0.3432Inherited
Nuclear receptor ligand-binding domain0.3854Inherited
Transforming growth factor (TGF)-beta0.3891Inherited
Pleckstrin-homology domain (PH domain)0.4007Inherited
FAS1 domain0.4255Inherited
EGF-type module0.4569Inherited
CCCH zinc finger0.485Inherited
Thyroglobulin type-1 domain0.4961Inherited
Rhodopsin-like0.5162Inherited
HLH, helix-loop-helix DNA-binding domain0.5325Inherited
PLC-like (P variant)0.5364Inherited
Integrin domains0.5381Inherited
Aquaporin-like0.6044Inherited
Caspase catalytic domain0.6204Inherited
Mammalian PLC0.6204Inherited
Homeodomain0.6502Inherited
28-residue LRR0.6712Inherited
Eukaryotic proteases0.688Inherited
Notch domain0.7067Inherited
Caspase recruitment domain, CARD0.7393Inherited
Cytochrome P4500.8089Inherited
Fibronectin type III0.809Inherited
Anion transport protein, cytoplasmic domain0.8709Inherited
ABC transporter ATPase domain-like0.8859Inherited
Fatty acid binding protein-like0.9124Inherited
Forkhead DNA-binding domain0.9177Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
GLA-domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Ammonium transporter0Direct
Lamin A/C globular tail domain0Direct
Transcription factor STAT-4 N-domain0.002595Inherited
STAT0.002595Inherited
Flavoproteins0.002595Inherited
Insulin-like0.004612Inherited
KA1-like0.006475Inherited
Apolipoprotein A-I0.01571Inherited
Nuclear receptor coactivator interlocking domain0.01571Inherited
Serum albumin-like0.01571Inherited
Toll/Interleukin receptor TIR domain0.01815Inherited
4-helical cytokines0.01962Inherited
Clathrin adaptor appendage domain0.02583Inherited
GAT-like domain0.04835Inherited
Kringle-like0.07059Inherited
GroEL equatorial domain-like0.09894Inherited
YWTD domain0.1106Inherited
PLP-dependent transferases0.1158Inherited
Actin-like ATPase domain0.1441Inherited
PYP-like sensor domain (PAS domain)0.1491Inherited
C-type lectin-like0.1525Inherited
Heme-dependent peroxidases0.1581Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.1728Inherited
Acyl-CoA dehydrogenase NM domain-like0.1728Inherited
CAD & PB1 domains0.1728Inherited
SH2 domain0.1887Inherited
FnI-like domain0.1991Inherited
Growth factor receptor domain0.2001Inherited
DHS-like NAD/FAD-binding domain0.2157Inherited
SMAD MH1 domain0.2157Inherited
Glycosyl hydrolase domain0.2157Inherited
t-snare proteins0.2687Inherited
PH domain-like0.2824Inherited
Hormone receptor domain0.3151Inherited
Transducin (alpha subunit), insertion domain0.3314Inherited
Multidrug efflux transporter AcrB transmembrane domain0.3349Inherited
EGF/Laminin0.3415Inherited
Nuclear receptor ligand-binding domain0.3748Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.3907Inherited
FAS1 domain0.4174Inherited
Family A G protein-coupled receptor-like0.4528Inherited
CCCH zinc finger0.4555Inherited
Thyroglobulin type-1 domain0.4638Inherited
HLH, helix-loop-helix DNA-binding domain0.4645Inherited
Integrin domains0.5287Inherited
alpha/beta-Hydrolases0.545Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.5645Inherited
Aquaporin-like0.5959Inherited
Riboflavin synthase domain-like0.5959Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.5959Inherited
Homeodomain-like0.6067Inherited
Caspase-like0.612Inherited
ClpP/crotonase0.612Inherited
PLC-like phosphodiesterases0.612Inherited
ENTH/VHS domain0.6582Inherited
Trypsin-like serine proteases0.6889Inherited
Notch domain0.6993Inherited
DEATH domain0.7376Inherited
Fibronectin type III0.745Inherited
Cytochrome P4500.8009Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.8228Inherited
E set domains0.8773Inherited
Cystine-knot cytokines0.8845Inherited
P-loop containing nucleoside triphosphate hydrolases0.8955Inherited
Phoshotransferase/anion transport protein0.9468Inherited
Thioredoxin-like0.9563Inherited
Lipocalins0.989Inherited
p53-like transcription factors1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    57196,50494
  • 57196 - EGF/Laminin
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    52058,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0Direct
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.0003956Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.002595Inherited
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.002595Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.002595Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.002595Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.002595Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.002595Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0104Inherited
    48552,48552
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 0.01571Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.02283Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.02583Inherited
    47769,47769
  • 47769 - SAM/Pointed domain
  • 47769 - SAM/Pointed domain
  • 0.04835Inherited
    48464,89009
  • 48464 - ENTH/VHS domain
  • 89009 - GAT-like domain
  • 0.04835Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.05619Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.08069Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.0908Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1386Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.1581Inherited
    111418,81321
  • 111418 - Hormone receptor domain
  • 81321 - Family A G protein-coupled receptor-like
  • 0.1667Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.1728Inherited
    57184,57610
  • 57184 - Growth factor receptor domain
  • 57610 - Thyroglobulin type-1 domain
  • 0.1768Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.1962Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.2157Inherited
    90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.3349Inherited
    53474,49723
  • 53474 - alpha/beta-Hydrolases
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 0.3349Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.3349Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.3463Inherited
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0.3801Inherited
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.3801Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.4113Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.4136Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.4174Inherited
    82153,82153
  • 82153 - FAS1 domain
  • 82153 - FAS1 domain
  • 0.4174Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.4339Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.4698Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.6993Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    49503,49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    52058,49265,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0Direct
    57184,52058,49265
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.002595Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.002595Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.002595Inherited
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.006475Inherited
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.006475Inherited
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.006475Inherited
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.03748Inherited
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.04835Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.05092Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.08867Inherited
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.09894Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.3314Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.4553Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.4698Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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