SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Mammalian Phenotype (MP): preweaning lethality

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   mortality/aging [MP:0010768] <4>(83|115) (89|67|51)
+ 1:   abnormal survival [MP:0010769] <10>(60|91) (67|55|40)
0:   preweaning lethality [MP:0010770] <4>(48|79) (55|45|38)
- 1:   lethality during fetal growth through weaning [MP:0010832] <5>(19|37) (23|28|22)
- 1:   prenatal lethality [MP:0002080] <5>(27|49) (30|23|16)
- 1:   preweaning lethality, complete penetrance [MP:0011100](2|2) (2|0|0)
- 1:   preweaning lethality, incomplete penetrance [MP:0011110](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
SWIB/MDM2 domain0Direct
SMAD MH1 domain0Direct
Amyloid beta a4 protein copper binding domain (domain 2)0Direct
Tricorn protease domain 20Direct
ATP-dependent DNA ligase DNA-binding domain0Direct
Roadblock/LC7 domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Protein prenylyltransferase0Direct
DNA clamp0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Ribonuclease PH domain 2-like0Direct
Zinc beta-ribbon0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
E2F-DP heterodimerization region0Direct
Nucleoporin domain0Direct
Conserved domain common to transcription factors TFIIS, elongin A, CRSP700Direct
Mob1/phocein0Direct
GroEL-intermediate domain like0Direct
Mib/herc2 domain-like0Direct
Uracil-DNA glycosylase-like0Direct
p53 tetramerization domain0Direct
2Fe-2S ferredoxin-like0Direct
CAPPD, an extracellular domain of amyloid beta A4 protein0Direct
A heparin-binding domain0Direct
SRF-like0Direct
Lamin A/C globular tail domain0Direct
Nucleic acid-binding proteins0.00000289Direct
Homeodomain-like0.0007573Direct
SCOP hierarchy in SUPERFAMILY0.01305Inherited
GAT-like domain0.03741Inherited
TB module/8-cys domain0.06345Inherited
GroEL apical domain-like0.06685Inherited
Growth factor receptor domain0.09862Inherited
HCP-like0.1031Inherited
Terpenoid synthases0.1175Inherited
"Winged helix" DNA-binding domain0.1224Inherited
ARM repeat0.1526Inherited
BRCT domain0.2549Inherited
Flavoproteins0.2752Inherited
L27 domain0.2863Inherited
p53-like transcription factors0.3201Inherited
HLH, helix-loop-helix DNA-binding domain0.3527Inherited
dsRNA-binding domain-like0.3535Inherited
Protein kinase-like (PK-like)0.4185Inherited
EGF/Laminin0.5634Inherited
ADC-like0.7382Inherited
Cullin homology domain0.8866Inherited
Subtilisin-like0.8866Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
gamma-adaptin C-terminal appendage domain-like0Direct
DNA ligase/mRNA capping enzyme postcatalytic domain0Direct
Ribonuclease PH domain 2-like0Direct
Retinoblastoma tumor suppressor domains0Direct
Amyloid beta a4 protein copper binding domain (domain 2)0Direct
Ribonuclease PH domain 1-like0Direct
U-box0Direct
Pointed domain0Direct
SRF-like0Direct
ATP-dependent DNA ligase catalytic domain0Direct
Lamin A/C globular tail domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Mib/herc2 domain0Direct
L domain0Direct
L-aspartase/fumarase0Direct
RUNT domain0Direct
p53 DNA-binding domain-like0Direct
Roadblock/LC7 domain0Direct
2Fe-2S ferredoxin domains from multidomain proteins0Direct
Group II chaperonin (CCT, TRIC), apical domain0Direct
DNA ligase0Direct
SMAD domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
SWIB/MDM2 domain0Direct
Adenosine/AMP deaminase0Direct
Cell cycle transcription factor e2f-dp0Direct
SMAD MH1 domain0Direct
A heparin-binding domain0Direct
p53 tetramerization domain0Direct
SMAD4-binding domain of oncoprotein Ski0Direct
CAPPD, an extracellular domain of amyloid beta A4 protein0Direct
Conserved domain common to transcription factors TFIIS, elongin A, CRSP700Direct
E2F dimerization segment0Direct
SIAH, seven in absentia homolog0Direct
Neurotrophin0Direct
Chromo barrel domain0Direct
Paired domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Mob1/phocein0Direct
Fumble-like0Direct
Histone lysine methyltransferases0.00001673Direct
T-box0.000249Direct
Homeodomain0.0007661Direct
ZZ domain0.008378Inherited
Erythroid transcription factor GATA-10.008378Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.008378Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.01609Inherited
Growth factor receptor domain0.01683Inherited
RecA protein-like (ATPase-domain)0.02663Inherited
Inhibitor of apoptosis (IAP) repeat0.02919Inherited
Tandem AAA-ATPase domain0.02929Inherited
TB module/8-cys domain0.0519Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.05401Inherited
NADPH-cytochrome p450 reductase-like0.05401Inherited
Extracellular domain of cell surface receptors0.06994Inherited
HMA, heavy metal-associated domain0.09868Inherited
GAT domain0.09868Inherited
C5 cytosine-specific DNA methylase, DCM0.09868Inherited
Laminin G-like module0.1345Inherited
Prohormone convertase 1 pro-domain0.1417Inherited
DNA polymerase I0.1417Inherited
Proprotein convertase P-domain0.1417Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.1677Inherited
ets domain0.1774Inherited
Forkhead DNA-binding domain0.2063Inherited
Adenain-like0.2271Inherited
L27 domain0.2636Inherited
Linker histone H1/H50.2636Inherited
HLH, helix-loop-helix DNA-binding domain0.2975Inherited
N-acetyl transferase, NAT0.4055Inherited
Protein kinases, catalytic subunit0.4873Inherited
Ubiquitin carboxyl-terminal hydrolase, UCH0.5577Inherited
Subtilases0.5838Inherited
Blood coagulation inhibitor (disintegrin)0.5893Inherited
Enabled/VASP homology 1 domain (EVH1 domain)0.59Inherited
SCF ubiquitin ligase complex WHB domain0.6401Inherited
Extended AAA-ATPase domain0.8273Inherited
Cullin homology domain0.8611Inherited
Armadillo repeat0.9112Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Zinc beta-ribbon0Direct
Conserved domain common to transcription factors TFIIS, elongin A, CRSP700Direct
SRF-like0Direct
CAPPD, an extracellular domain of amyloid beta A4 protein0Direct
E2F-DP heterodimerization region0Direct
SWIB/MDM2 domain0Direct
p53 tetramerization domain0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Ribonuclease PH domain 2-like0Direct
Protein prenylyltransferase0Direct
Uracil-DNA glycosylase-like0Direct
2Fe-2S ferredoxin-like0Direct
Nucleoporin domain0Direct
Roadblock/LC7 domain0Direct
DNA clamp0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
A heparin-binding domain0Direct
SMAD MH1 domain0Direct
GroEL-intermediate domain like0Direct
Mib/herc2 domain-like0Direct
Lamin A/C globular tail domain0Direct
Amyloid beta a4 protein copper binding domain (domain 2)0Direct
Mob1/phocein0Direct
ATP-dependent DNA ligase DNA-binding domain0Direct
Tricorn protease domain 20Direct
Nucleic acid-binding proteins0.000001216Direct
Homeodomain-like0.000407Direct
HMG-box0.0007299Direct
GAT-like domain0.02584Inherited
TB module/8-cys domain0.04599Inherited
GroEL apical domain-like0.04865Inherited
Growth factor receptor domain0.07438Inherited
Orange domain-like0.07808Inherited
Inhibitor of apoptosis (IAP) repeat0.07808Inherited
HCP-like0.07808Inherited
Terpenoid synthases0.09054Inherited
HMA, heavy metal-associated domain0.09054Inherited
"Winged helix" DNA-binding domain0.09457Inherited
ARM repeat0.121Inherited
BRCT domain0.2143Inherited
Flavoproteins0.2335Inherited
Acyl-CoA N-acyltransferases (Nat)0.2344Inherited
L27 domain0.244Inherited
p53-like transcription factors0.2761Inherited
HLH, helix-loop-helix DNA-binding domain0.3073Inherited
dsRNA-binding domain-like0.3081Inherited
Protein kinase-like (PK-like)0.3716Inherited
EGF/Laminin0.5169Inherited
Blood coagulation inhibitor (disintegrin)0.5576Inherited
Riboflavin synthase domain-like0.6584Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.6584Inherited
ADC-like0.6995Inherited
Cullin homology domain0.8586Inherited
Subtilisin-like0.8586Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0Direct
    63748,82199
  • 63748 - Tudor/PWWP/MBT
  • 82199 - SET domain
  • 0Direct
    56491,89811
  • 56491 - A heparin-binding domain
  • 89811 - Amyloid beta a4 protein copper binding domain (domain 2)
  • 0Direct
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,82895
  • 57184 - Growth factor receptor domain
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    82199,57903
  • 82199 - SET domain
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    50729,57889
  • 50729 - PH domain-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0Direct
    57903,63748
  • 57903 - FYVE/PHD zinc finger
  • 63748 - Tudor/PWWP/MBT
  • 0Direct
    46955,63763
  • 46955 - Putative DNA-binding domain
  • 63763 - SAND domain-like
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    64268,103657
  • 64268 - PX domain
  • 103657 - BAR/IMD domain-like
  • 0Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0Direct
    50729,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    117018,56091
  • 117018 - ATP-dependent DNA ligase DNA-binding domain
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    52058,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    49562,51045
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 51045 - WW domain
  • 0Direct
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.007033Inherited
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.01348Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.01348Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.02584Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.02584Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.02584Inherited
    48464,89009
  • 48464 - ENTH/VHS domain
  • 89009 - GAT-like domain
  • 0.02584Inherited
    47459,158457
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 158457 - Orange domain-like
  • 0.07808Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.09054Inherited
    52743,49785
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0.1305Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1335Inherited
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1536Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.2125Inherited
    101288,50156
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 0.2335Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.2335Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.3375Inherited
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0.5321Inherited
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0.5576Inherited
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.6391Inherited
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.6391Inherited
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0.6995Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    49265,48726,49265
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0Direct
    63748,82199,57903
  • 63748 - Tudor/PWWP/MBT
  • 82199 - SET domain
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0Direct
    50729,50156,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    57196,57196,49899
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0Direct
    57424,57196,57196
  • 57424 - LDL receptor-like module
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    75399,75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    117018,56091,50249
  • 117018 - ATP-dependent DNA ligase DNA-binding domain
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    63748,63748,63748
  • 63748 - Tudor/PWWP/MBT
  • 63748 - Tudor/PWWP/MBT
  • 63748 - Tudor/PWWP/MBT
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57196,63825
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57903,63748,82199
  • 57903 - FYVE/PHD zinc finger
  • 63748 - Tudor/PWWP/MBT
  • 82199 - SET domain
  • 0Direct
    57850,49599,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 49599 - TRAF domain-like
  • 0Direct
    52058,49265,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0Direct
    54928,54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0Direct
    57184,52058,49265
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    100895,100895,100895
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 0Direct
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0002192Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0009027Direct
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.02584Inherited
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.02584Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.04865Inherited
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.04865Inherited
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.07808Inherited
    54897,52743,49785
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0.1305Inherited
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1536Inherited
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1536Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.2125Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.3697Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)