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Mammalian Phenotype (MP): lethality during fetal growth through weaning

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   mortality/aging [MP:0010768] <4>(83|115) (89|67|51)
+ + 2:   abnormal survival [MP:0010769] <10>(60|91) (67|55|40)
+ 1:   preweaning lethality [MP:0010770] <4>(48|79) (55|45|38)
0:   lethality during fetal growth through weaning [MP:0010832] <5>(19|37) (23|28|22)
- 1:   perinatal lethality [MP:0002081] <3>(7|10) (8|13|10)
- 1:   lethality throughout fetal growth and development [MP:0006208] <2>(5|8) (6|6|7)
- 1:   postnatal lethality [MP:0002082] <2>(3|12) (6|7|5)
- 1:   lethality during fetal growth through weaning, complete penetrance [MP:0011111](0|0) (0|0|0)
- 1:   lethality during fetal growth through weaning, incomplete penetrance [MP:0011112](1|2) (1|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Amyloid beta a4 protein copper binding domain (domain 2)0Direct
ATP-dependent DNA ligase DNA-binding domain0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
p53 tetramerization domain0Direct
CAPPD, an extracellular domain of amyloid beta A4 protein0Direct
A heparin-binding domain0Direct
SRF-like0Direct
Lamin A/C globular tail domain0Direct
Homeodomain-like0.0000000000005869Direct
HLH, helix-loop-helix DNA-binding domain0.0001225Direct
EGF/Laminin0.0002164Direct
GAT-like domain0.003812Inherited
Protein kinase-like (PK-like)0.003919Inherited
Growth factor receptor domain0.005949Inherited
L27 domain0.05602Inherited
p53-like transcription factors0.05838Inherited
E2F-DP heterodimerization region0.09954Inherited
TB module/8-cys domain0.1397Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
DNA ligase/mRNA capping enzyme postcatalytic domain0Direct
Retinoblastoma tumor suppressor domains0Direct
Amyloid beta a4 protein copper binding domain (domain 2)0Direct
SRF-like0Direct
ATP-dependent DNA ligase catalytic domain0Direct
Lamin A/C globular tail domain0Direct
L domain0Direct
RUNT domain0Direct
p53 DNA-binding domain-like0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
A heparin-binding domain0Direct
p53 tetramerization domain0Direct
CAPPD, an extracellular domain of amyloid beta A4 protein0Direct
E2F dimerization segment0Direct
Neurotrophin0Direct
Paired domain0Direct
Homeodomain0.0000000000006241Direct
Forkhead DNA-binding domain0.00002381Direct
HLH, helix-loop-helix DNA-binding domain0.0002234Direct
Erythroid transcription factor GATA-10.000354Direct
Growth factor receptor domain0.002182Inherited
Protein kinases, catalytic subunit0.00367Inherited
Laminin G-like module0.01751Inherited
HMA, heavy metal-associated domain0.02351Inherited
GAT domain0.02351Inherited
Cell cycle transcription factor e2f-dp0.04503Inherited
L27 domain0.05059Inherited
Extracellular domain of cell surface receptors0.09175Inherited
Blood coagulation inhibitor (disintegrin)0.1144Inherited
TB module/8-cys domain0.1297Inherited
Enabled/VASP homology 1 domain (EVH1 domain)0.2046Inherited
gamma-adaptin C-terminal appendage domain-like0.2574Inherited
Adenosine/AMP deaminase0.2574Inherited
Pointed domain0.3021Inherited
ZZ domain0.3021Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.3021Inherited
ets domain0.3795Inherited


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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SRF-like0Direct
CAPPD, an extracellular domain of amyloid beta A4 protein0Direct
p53 tetramerization domain0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
A heparin-binding domain0Direct
Lamin A/C globular tail domain0Direct
Amyloid beta a4 protein copper binding domain (domain 2)0Direct
ATP-dependent DNA ligase DNA-binding domain0Direct
Homeodomain-like0.0000000000002125Direct
HLH, helix-loop-helix DNA-binding domain0.00006019Direct
EGF/Laminin0.0001099Direct
GAT-like domain0.002239Inherited
Protein kinase-like (PK-like)0.002306Inherited
Growth factor receptor domain0.003593Inherited
Orange domain-like0.008704Inherited
HMA, heavy metal-associated domain0.01924Inherited
L27 domain0.04002Inherited
p53-like transcription factors0.04191Inherited
E2F-DP heterodimerization region0.0751Inherited
Blood coagulation inhibitor (disintegrin)0.08895Inherited
TB module/8-cys domain0.1096Inherited
Inhibitor of apoptosis (IAP) repeat0.159Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
56491,89811
  • 56491 - A heparin-binding domain
  • 89811 - Amyloid beta a4 protein copper binding domain (domain 2)
  • 0Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0Direct
    50729,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    117018,56091
  • 117018 - ATP-dependent DNA ligase DNA-binding domain
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 0Direct
    54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    52058,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    49562,51045
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 51045 - WW domain
  • 0Direct
    48464,89009
  • 48464 - ENTH/VHS domain
  • 89009 - GAT-like domain
  • 0.002239Inherited
    47459,158457
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 158457 - Orange domain-like
  • 0.008704Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.01578Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.01924Inherited
    101288,50156
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 0.04786Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.04786Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.05429Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.0751Inherited
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0.08895Inherited
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.1096Inherited
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.1096Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.1096Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.159Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.159Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.159Inherited
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.2642Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    49265,48726,49265
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0Direct
    50729,50156,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    117018,56091,50249
  • 117018 - ATP-dependent DNA ligase DNA-binding domain
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    52058,49265,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0Direct
    54928,54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    57184,52058,49265
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    100895,100895,100895
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 0Direct
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.0001852Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.002239Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.006681Inherited
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.006681Inherited
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.008704Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.05429Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.05674Inherited
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.1096Inherited
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.1096Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.159Inherited
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0.2301Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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