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Mammalian Phenotype (MP): increased hematopoietic cell number

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   mammalian phenotype [MP:0000001] <29>
+ + + + 4:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + + 3:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(58|86) (66|47|21)
+ + 2:   abnormal hematopoietic cell morphology [MP:0013656] <9>(49|76) (60|43|18)
+ 1:   abnormal hematopoietic cell number [MP:0011180] <7>(34|56) (43|29|13)
0:   increased hematopoietic cell number [MP:0011181] <4>(12|25) (19|11|7)
- 1:   increased myeloid cell number [MP:0013663] <6>(2|2) (2|0|0)
- 1:   increased dendritic cell number [MP:0008126] <5>(0|0) (0|0|0)
- 1:   increased leukocyte cell number [MP:0000218] <5>(9|22) (15|11|7)
- 1:   increased hematopoietic stem cell number [MP:0004809](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
SPOC domain-like0Direct
L30e-like0.0002239Direct
Flavoproteins0.0009878Direct
p53-like transcription factors0.001522Inherited
AraD/HMP-PK domain-like0.005018Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.1664Inherited
Riboflavin synthase domain-like0.1664Inherited
DBL homology domain (DH-domain)0.2357Inherited
Nucleic acid-binding proteins0.2967Inherited
Toll/Interleukin receptor TIR domain0.5706Inherited
Calponin-homology domain, CH-domain0.5706Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
RUNT domain0Direct
TNF receptor-like0.000000005852Direct
Rel/Dorsal transcription factors, DNA-binding domain0.000005827Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.00004392Direct
Notch domain0.0007272Direct
Tissue inhibitor of metalloproteinases, TIMP0.003509Inherited
AraD-like aldolase/epimerase0.003509Inherited
Cytochrome p450 reductase N-terminal domain-like0.003509Inherited
Bcl-2 inhibitors of programmed cell death0.004059Inherited
Interferon regulatory factor0.004059Inherited
SH2 domain0.004969Inherited
Nuclear receptor coactivator interlocking domain0.01127Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.01127Inherited
NADPH-cytochrome p450 reductase-like0.01127Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.04052Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.06167Inherited
DEATH domain, DD0.08092Inherited
DBL homology domain (DH-domain)0.2124Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.2173Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.2968Inherited
Interleukin-1 (IL-1)0.2968Inherited
Toll/Interleukin receptor TIR domain0.3864Inherited
Short-chain cytokines0.472Inherited
Calponin-homology domain, CH-domain0.5458Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SPOC domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
L30e-like0.0001136Direct
Flavoproteins0.0005383Direct
Notch domain0.0006027Direct
p53-like transcription factors0.0008533Direct
NAD kinase/diacylglycerol kinase-like0.001857Inherited
AraD/HMP-PK domain-like0.003006Inherited
Bcl-2 inhibitors of programmed cell death0.003355Inherited
SH2 domain0.003662Inherited
TNF receptor-like0.005203Inherited
Nuclear receptor coactivator interlocking domain0.009743Inherited
Riboflavin synthase domain-like0.133Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.133Inherited
DBL homology domain (DH-domain)0.1965Inherited
CCCH zinc finger0.2066Inherited
Nucleic acid-binding proteins0.2536Inherited
Calponin-homology domain, CH-domain0.5243Inherited
Toll/Interleukin receptor TIR domain0.5243Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0000001183Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.00000399Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0001143Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.0003691Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.002374Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.01141Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.1965Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.2835Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.2835Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.003006Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.003006Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.01141Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.2835Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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