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Mammalian Phenotype (MP): decreased hematopoietic cell number

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   mammalian phenotype [MP:0000001] <29>
+ + + + 4:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + + 3:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(58|86) (66|47|21)
+ + 2:   abnormal hematopoietic cell morphology [MP:0013656] <9>(49|76) (60|43|18)
+ 1:   abnormal hematopoietic cell number [MP:0011180] <7>(34|56) (43|29|13)
0:   decreased hematopoietic cell number [MP:0011182] <5>(21|34) (27|21|11)
- 1:   decreased dendritic cell number [MP:0008127] <5>(2|4) (2|1|0)
- 1:   decreased leukocyte cell number [MP:0000221] <5>(17|28) (24|18|10)
- 1:   decreased myeloid cell number [MP:0013662] <5>(2|5) (2|2|0)
- 1:   decreased hematopoietic stem cell number [MP:0004810] <1>(1|1) (1|1|0)
- 1:   pancytopenia [MP:0005152](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
PsbU/PolX domain-like0Direct
SPOC domain-like0Direct
4-helical cytokines0.00000002007Direct
DNA polymerase beta, N-terminal domain-like0.002255Inherited
Ran binding protein zinc finger-like0.005326Inherited
Integrin alpha N-terminal domain0.007004Inherited
Bcl-2 inhibitors of programmed cell death0.01193Inherited
WWE domain0.01765Inherited
p53-like transcription factors0.02784Inherited
A DNA-binding domain in eukaryotic transcription factors0.05623Inherited
Integrin domains0.09784Inherited
DBL homology domain (DH-domain)0.1304Inherited
SH2 domain0.1508Inherited
Cysteine-rich domain0.2177Inherited
Calponin-homology domain, CH-domain0.2395Inherited
Cyclin-like0.3186Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.3766Inherited
SMAD/FHA domain0.4682Inherited
E2F-DP heterodimerization region0.5262Inherited
DEATH domain0.6917Inherited
MHC antigen-recognition domain0.8236Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
RUNT domain0Direct
DNA polymerase beta-like, second domain0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
DNA polymerase beta-like0Direct
Proteasome subunits0Direct
Short-chain cytokines0.000000004682Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0000245Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.000189Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0006203Direct
DNA polymerase beta, N-terminal domain-like0.001528Inherited
Pointed domain0.001571Inherited
Ran binding protein zinc finger-like0.003966Inherited
Erythroid transcription factor GATA-10.004245Inherited
WWE domain0.005677Inherited
Bcl-2 inhibitors of programmed cell death0.008887Inherited
Interferon regulatory factor0.008887Inherited
Pleckstrin-homology domain (PH domain)0.02023Inherited
Noncollagenous (NC1) domain of collagen IV0.03881Inherited
A DNA-binding domain in eukaryotic transcription factors0.0461Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.06507Inherited
Integrin domains0.08051Inherited
PLC-like (P variant)0.09701Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.1165Inherited
ets domain0.1165Inherited
DBL homology domain (DH-domain)0.1182Inherited
SH2 domain0.135Inherited
Toll/Interleukin receptor TIR domain0.1674Inherited
SH3-domain0.1878Inherited
Calponin-homology domain, CH-domain0.2242Inherited
Cyclin0.3444Inherited
Cell cycle transcription factor e2f-dp0.4933Inherited
E2F dimerization segment0.4933Inherited
C1 set domains (antibody constant domain-like)0.665Inherited
MHC antigen-recognition domain0.8046Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SPOC domain-like0Direct
PsbU/PolX domain-like0Direct
4-helical cytokines0.000000007621Direct
DNA polymerase beta, N-terminal domain-like0.001288Inherited
Ran binding protein zinc finger-like0.003205Inherited
Integrin alpha N-terminal domain0.004291Inherited
Bcl-2 inhibitors of programmed cell death0.007557Inherited
WWE domain0.0115Inherited
p53-like transcription factors0.01881Inherited
beta-beta-alpha zinc fingers0.02266Inherited
A DNA-binding domain in eukaryotic transcription factors0.04018Inherited
Integrin domains0.07374Inherited
DBL homology domain (DH-domain)0.1015Inherited
SH2 domain0.1194Inherited
Toll/Interleukin receptor TIR domain0.1305Inherited
SH3-domain0.1691Inherited
Cysteine-rich domain0.1797Inherited
Calponin-homology domain, CH-domain0.2Inherited
Cyclin-like0.2746Inherited
Protein kinase-like (PK-like)0.3198Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.3306Inherited
SMAD/FHA domain0.4203Inherited
E2F-DP heterodimerization region0.4789Inherited
DEATH domain0.6504Inherited
Acyl-CoA N-acyltransferases (Nat)0.7312Inherited
C-type lectin-like0.7497Inherited
MHC antigen-recognition domain0.7905Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57424,50494
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.00001815Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.0003366Direct
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.001952Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.001952Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.00486Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.01768Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.0219Inherited
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 0.02928Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.08939Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.1328Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.2345Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.3306Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.3306Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.4789Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.8352Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 1Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    57424,57424,50494
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0004909Direct
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.001952Inherited
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.005403Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.005403Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.0219Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.2406Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.8324Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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