SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Mammalian Phenotype (MP): abnormal blood cell physiology

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ 1:   abnormal hematopoietic system physiology [MP:0001545] <5>(39|53) (40|38|21)
0:   abnormal blood cell physiology [MP:0012382] <3>(38|53) (39|38|21)
- 1:   abnormal leukocyte physiology [MP:0002442] <5>(34|48) (36|33|20)
- 1:   abnormal erythrocyte physiology [MP:0003656] <4>(1|1) (1|1|0)
- 1:   abnormal platelet physiology [MP:0005464] <2>(5|8) (6|5|1)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
DEATH domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Transcription factor STAT-4 N-domain0Direct
STAT0Direct
TNF receptor-like0.0000001446Direct
p53-like transcription factors0.000002195Direct
C-type lectin-like0.00001665Direct
Caspase-like0.00005266Direct
TNF-like0.0002755Direct
Interleukin 8-like chemokines0.0002868Direct
Integrin domains0.0004525Direct
Cysteine-rich domain0.001043Inherited
Inhibitor of apoptosis (IAP) repeat0.002757Inherited
Integrin alpha N-terminal domain0.009213Inherited
Integrin beta tail domain0.0203Inherited
DBL homology domain (DH-domain)0.02855Inherited
Transducin (alpha subunit), insertion domain0.04929Inherited
PH domain-like0.0714Inherited
Family A G protein-coupled receptor-like0.07425Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.08468Inherited
Flavoproteins0.08797Inherited
WWE domain0.08797Inherited
PLC-like phosphodiesterases0.09724Inherited
E set domains0.1002Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.1114Inherited
L30e-like0.1259Inherited
SH3-domain0.1299Inherited
Complement control module/SCR domain0.1807Inherited
4-helical cytokines0.4781Inherited
EGF/Laminin0.491Inherited
Toll/Interleukin receptor TIR domain0.4962Inherited
SH2 domain0.559Inherited
MHC antigen-recognition domain0.6006Inherited
vWA-like0.6006Inherited
SMAD/FHA domain0.6735Inherited
A DNA-binding domain in eukaryotic transcription factors0.784Inherited
Bcl-2 inhibitors of programmed cell death0.784Inherited
L domain-like0.7849Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
STAT0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cysteine rich domain0Direct
Proteasome subunits0Direct
Transcription factor STAT-4 N-domain0Direct
STAT DNA-binding domain0Direct
V set domains (antibody variable domain-like)0.000000006084Direct
C1 set domains (antibody constant domain-like)0.0000001128Direct
TNF receptor-like0.000000121Direct
C-type lectin domain0.0000002879Direct
Rel/Dorsal transcription factors, DNA-binding domain0.000001133Direct
Caspase recruitment domain, CARD0.00002447Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.00003112Direct
DEATH domain, DD0.00008507Direct
Pyrin domain, PYD0.0001091Direct
Caspase catalytic domain0.0001361Direct
Pleckstrin-homology domain (PH domain)0.0001969Direct
Interleukin 8-like chemokines0.0002282Direct
TNF-like0.0002299Direct
Integrin domains0.0003581Direct
Inhibitor of apoptosis (IAP) repeat0.0004643Direct
PLC-like (P variant)0.0005401Direct
28-residue LRR0.001167Inherited
Interferon regulatory factor0.001644Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.00199Inherited
Cytochrome p450 reductase N-terminal domain-like0.007261Inherited
Integrin alpha N-terminal domain0.00817Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.01588Inherited
Integrin beta tail domain0.01588Inherited
Interleukin 17F, IL-17F0.02205Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.02205Inherited
NADPH-cytochrome p450 reductase-like0.02205Inherited
DBL homology domain (DH-domain)0.02598Inherited
Integrin beta EGF-like domains0.02932Inherited
Transducin (alpha subunit), insertion domain0.0416Inherited
WWE domain0.04448Inherited
Mammalian PLC0.04558Inherited
Rhodopsin-like0.07271Inherited
Integrin A (or I) domain0.09706Inherited
SH3-domain0.1031Inherited
Complement control module/SCR domain0.1711Inherited
I set domains0.2731Inherited
EGF-type module0.469Inherited
Toll/Interleukin receptor TIR domain0.4736Inherited
FHA domain0.4736Inherited
SH2 domain0.5156Inherited
MHC antigen-recognition domain0.5596Inherited
Short-chain cytokines0.6357Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.6912Inherited
A DNA-binding domain in eukaryotic transcription factors0.7519Inherited
Bcl-2 inhibitors of programmed cell death0.7519Inherited
G proteins0.8557Inherited
ets domain0.9482Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
DEATH domain0Direct
Transcription factor STAT-4 N-domain0Direct
STAT0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
TNF receptor-like0.0000000572Direct
p53-like transcription factors0.0000009092Direct
C-type lectin-like0.000007405Direct
Caspase-like0.0000247Direct
TNF-like0.0001411Direct
Interleukin 8-like chemokines0.0001471Direct
Integrin domains0.0002376Direct
Cysteine-rich domain0.0005702Direct
Inhibitor of apoptosis (IAP) repeat0.00159Inherited
Integrin alpha N-terminal domain0.005724Inherited
Integrin beta tail domain0.01335Inherited
DBL homology domain (DH-domain)0.01932Inherited
RNI-like0.03248Inherited
Transducin (alpha subunit), insertion domain0.03479Inherited
PH domain-like0.05233Inherited
Family A G protein-coupled receptor-like0.05457Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.06287Inherited
WWE domain0.06561Inherited
Flavoproteins0.06561Inherited
PLC-like phosphodiesterases0.0732Inherited
E set domains0.07567Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.08528Inherited
L30e-like0.09768Inherited
SH3-domain0.101Inherited
Complement control module/SCR domain0.1459Inherited
4-helical cytokines0.4305Inherited
EGF/Laminin0.4433Inherited
Toll/Interleukin receptor TIR domain0.4486Inherited
SH2 domain0.5124Inherited
MHC antigen-recognition domain0.5551Inherited
vWA-like0.5551Inherited
SMAD/FHA domain0.6314Inherited
Bcl-2 inhibitors of programmed cell death0.7481Inherited
A DNA-binding domain in eukaryotic transcription factors0.7481Inherited
L domain-like0.7491Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0Direct
    50370,57440
  • 50370 - Ricin B-like lectins
  • 57440 - Kringle-like
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    57440,56436
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    48366,47473
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0000006964Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.000001211Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.00001566Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.000365Direct
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.000365Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0004255Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.001281Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.00159Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.002589Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.002589Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.004284Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.004284Inherited
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.006175Inherited
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.008987Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.008987Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.01335Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.01335Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.01912Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0246Inherited
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0.02599Inherited
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.02599Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.02768Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.07768Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.1386Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.2936Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.51Inherited
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 0.7481Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.7809Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.8143Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.8505Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    50370,57440,56436
  • 50370 - Ricin B-like lectins
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    57440,56436,56436
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    48366,47473,57889
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 57889 - Cysteine-rich domain
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.001523Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.001523Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.00159Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.002589Inherited
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.004106Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.004284Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.01335Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.01912Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.03479Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.6051Inherited
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.8505Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.8505Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)