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Mammalian Phenotype (MP): abnormal organ/body region tumor incidence

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   neoplasm [MP:0002006] <2>(32|37) (38|18|7)
+ + 2:   altered tumor susceptibility [MP:0002166] <3>(25|29) (30|11|3)
+ 1:   abnormal tumor incidence [MP:0002019] <6>(25|29) (30|11|3)
0:   abnormal organ/body region tumor incidence [MP:0013152] <2>(21|24) (24|8|3)
- 1:   decreased organ/body region tumor incidence [MP:0010282] <15>(0|0) (0|0|0)
- 1:   increased organ/body region tumor incidence [MP:0010274] <14>(21|24) (24|8|3)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
SMAD MH1 domain0.000003996Direct
Nucleic acid-binding proteins0.0002022Direct
SMAD/FHA domain0.0003342Direct
DNA-glycosylase0.000622Direct
SPOC domain-like0.000622Direct
Cyclin-like0.001083Inherited
DNA repair protein MutS, domain III0.002097Inherited
Notch domain0.002097Inherited
SAND domain-like0.002097Inherited
Putative DNA-binding domain0.008499Inherited
BRCT domain0.009365Inherited
RING/U-box0.04508Inherited
CCCH zinc finger0.04616Inherited
SET domain0.05601Inherited
ARM repeat0.09628Inherited
Protein kinase-like (PK-like)0.1434Inherited
p53-like transcription factors0.2723Inherited
4-helical cytokines0.4186Inherited
Intermediate filament protein, coiled coil region0.5291Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.6933Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
p53 DNA-binding domain-like0Direct
p53 tetramerization domain0Direct
SMAD domain0.000002901Direct
SMAD MH1 domain0.000002901Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0.000002901Direct
DNA polymerase I0.0002133Direct
Pointed domain0.0005785Direct
L domain0.0005785Direct
Notch domain0.00155Inherited
DNA repair protein MutS, domain III0.00155Inherited
p120GAP domain-like0.003765Inherited
Single strand DNA-binding domain, SSB0.006676Inherited
Short-chain cytokines0.01155Inherited
Histone lysine methyltransferases0.0196Inherited
CCCH zinc finger0.03943Inherited
FHA domain0.06197Inherited
Protein kinases, catalytic subunit0.1308Inherited
Phosphotyrosine-binding domain (PTB)0.2703Inherited
ABC transporter ATPase domain-like0.2956Inherited
DnaQ-like 3'-5' exonuclease0.4876Inherited
Forkhead DNA-binding domain0.4879Inherited
Intermediate filament protein, coiled coil region0.4881Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.8107Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
SMAD MH1 domain0.000001702Direct
Nucleic acid-binding proteins0.0001022Direct
SMAD/FHA domain0.0001736Direct
SPOC domain-like0.0003306Direct
DNA-glycosylase0.0003306Direct
Cyclin-like0.0005936Direct
DNA repair protein MutS, domain III0.001195Inherited
Notch domain0.001195Inherited
SAND domain-like0.001195Inherited
Putative DNA-binding domain0.005257Inherited
BRCT domain0.005831Inherited
RING/U-box0.03161Inherited
CCCH zinc finger0.03246Inherited
SET domain0.04001Inherited
ARM repeat0.07238Inherited
Protein kinase-like (PK-like)0.1129Inherited
p53-like transcription factors0.2307Inherited
DNA/RNA polymerases0.2775Inherited
4-helical cytokines0.3717Inherited
Intermediate filament protein, coiled coil region0.4819Inherited
Leucine zipper domain0.5467Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.6521Inherited
Cysteine-rich domain0.7514Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.0003306Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0004247Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0004247Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.001195Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.008891Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.06669Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.4819Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0003306Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0004247Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.04096Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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