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Mammalian Phenotype (MP): abnormal hematopoietic cell morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ 1:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(59|86) (66|47|21)
0:   abnormal hematopoietic cell morphology [MP:0013656] <9>(50|76) (60|43|18)
- 1:   abnormal myeloid cell morphology [MP:0013658] <8>(20|41) (26|23|8)
- 1:   abnormal hematopoietic cell number [MP:0011180] <7>(34|56) (43|29|13)
- 1:   abnormal blood cell morphology [MP:0013657] <4>(31|49) (37|35|14)
- 1:   abnormal hematopoietic stem cell morphology [MP:0004808] <4>(2|3) (2|3|0)
- 1:   abnormal leukocyte morphology [MP:0008246] <4>(37|61) (47|29|15)
- 1:   abnormal bone marrow hematopoietic cell morphology [MP:0013660] <2>(2|3) (2|3|0)
- 1:   abnormal common lymphocyte progenitor cell morphology [MP:0008249] <2>(0|1) (0|0|0)
- 1:   abnormal common myeloid progenitor cell morphology [MP:0006410] <2>(1|1) (1|2|0)
- 1:   abnormal hematopoietic precursor cell morphology [MP:0013707] <1>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Transcription factor STAT-4 N-domain0Direct
PsbU/PolX domain-like0Direct
SPOC domain-like0Direct
STAT0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
TNF receptor-like0.0000007544Direct
Interleukin 8-like chemokines0.000192Direct
ARID-like0.0008103Direct
Integrin domains0.0008609Direct
Integrin beta tail domain0.00224Inherited
Immunoglobulin0.0035Inherited
L30e-like0.008851Inherited
DNA polymerase beta, N-terminal domain-like0.01514Inherited
Notch domain0.01514Inherited
Flavoproteins0.02022Inherited
BRCT domain0.02736Inherited
Triple coiled coil domain of C-type lectins0.03741Inherited
AraD/HMP-PK domain-like0.03741Inherited
Terpenoid cyclases/Protein prenyltransferases0.04136Inherited
Integrin alpha N-terminal domain0.06175Inherited
Toll/Interleukin receptor TIR domain0.06175Inherited
Ran binding protein zinc finger-like0.07396Inherited
A DNA-binding domain in eukaryotic transcription factors0.07396Inherited
PH domain-like0.07994Inherited
E2F-DP heterodimerization region0.08791Inherited
WWE domain0.08791Inherited
SH3-domain0.128Inherited
TIMP-like0.1427Inherited
4-helical cytokines0.1463Inherited
SH2 domain0.2045Inherited
Cyclin-like0.2153Inherited
Cysteine-rich domain0.226Inherited
SMAD/FHA domain0.248Inherited
DBL homology domain (DH-domain)0.2717Inherited
SET domain0.275Inherited
Nucleotidyltransferase0.3384Inherited
MHC antigen-recognition domain0.3482Inherited
Nucleic acid-binding proteins0.3482Inherited
BAR/IMD domain-like0.5022Inherited
Protein kinase-like (PK-like)0.5501Inherited
Ankyrin repeat0.5641Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.5768Inherited
Calponin-homology domain, CH-domain0.6079Inherited
p53-like transcription factors0.6536Inherited
Bcl-2 inhibitors of programmed cell death0.6657Inherited
DEATH domain0.7378Inherited
Riboflavin synthase domain-like0.7686Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.7686Inherited
Nuclear receptor ligand-binding domain0.8177Inherited
DNA/RNA polymerases0.9989Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
RUNT domain0Direct
STAT DNA-binding domain0Direct
Proteasome subunits0Direct
Interleukin 17F, IL-17F0Direct
DNA polymerase beta-like, second domain0Direct
beta-glycanases0Direct
DNA polymerase beta-like0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
BAFF receptor-like0Direct
TNF receptor-like0.000002165Direct
Short-chain cytokines0.000002237Direct
Interleukin 8-like chemokines0.0001343Direct
ARID domain0.0005454Direct
Integrin domains0.0006139Direct
Integrin beta tail domain0.001522Inherited
Interferons/interleukin-10 (IL-10)0.002586Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.006391Inherited
Integrin beta EGF-like domains0.006391Inherited
Pleckstrin-homology domain (PH domain)0.009474Inherited
Interleukin-1 (IL-1)0.01108Inherited
Notch domain0.01108Inherited
DNA polymerase beta, N-terminal domain-like0.01108Inherited
Myb/SANT domain0.01212Inherited
Pointed domain0.0152Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.0152Inherited
C2 set domains0.01633Inherited
Cytochrome p450 reductase N-terminal domain-like0.02836Inherited
Triple coiled coil domain of C-type lectins0.02836Inherited
AraD-like aldolase/epimerase0.02836Inherited
Tissue inhibitor of metalloproteinases, TIMP0.02836Inherited
WWE domain0.03472Inherited
E2F dimerization segment0.03472Inherited
Noncollagenous (NC1) domain of collagen IV0.03472Inherited
Erythroid transcription factor GATA-10.0348Inherited
Ran binding protein zinc finger-like0.06154Inherited
A DNA-binding domain in eukaryotic transcription factors0.06154Inherited
Interferon regulatory factor0.06411Inherited
Nuclear receptor coactivator interlocking domain0.07699Inherited
Tetraspanin0.07699Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.07699Inherited
NADPH-cytochrome p450 reductase-like0.07699Inherited
Toll/Interleukin receptor TIR domain0.08177Inherited
V set domains (antibody variable domain-like)0.08655Inherited
Enabled/VASP homology 1 domain (EVH1 domain)0.1021Inherited
SH3-domain0.1149Inherited
Eps15 homology domain (EH domain)0.1407Inherited
Cyclin0.1489Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.1652Inherited
Cell cycle transcription factor e2f-dp0.1769Inherited
SH2 domain0.1897Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.2145Inherited
PLC-like (P variant)0.2357Inherited
C1 set domains (antibody constant domain-like)0.2547Inherited
DBL homology domain (DH-domain)0.2568Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.2972Inherited
MHC antigen-recognition domain0.3212Inherited
DEATH domain, DD0.3212Inherited
ets domain0.3735Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.5135Inherited
FHA domain0.5294Inherited
Ankyrin repeat0.5474Inherited
Long-chain cytokines0.5476Inherited
Pyrin domain, PYD0.5918Inherited
Calponin-homology domain, CH-domain0.5955Inherited
Bcl-2 inhibitors of programmed cell death0.6388Inherited
Caspase recruitment domain, CARD0.6894Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.7735Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.7735Inherited
Nuclear receptor0.8042Inherited
Nuclear receptor ligand-binding domain0.8042Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.8053Inherited
MATH domain0.9275Inherited
DNA polymerase I0.9531Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SPOC domain-like0Direct
Transcription factor STAT-4 N-domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
STAT0Direct
PsbU/PolX domain-like0Direct
TNF receptor-like0.0000003058Direct
Interleukin 8-like chemokines0.00009679Direct
ARID-like0.0004367Direct
Integrin domains0.0004657Direct
Integrin beta tail domain0.001278Inherited
Immunoglobulin0.00205Inherited
L30e-like0.005482Inherited
Notch domain0.009738Inherited
DNA polymerase beta, N-terminal domain-like0.009738Inherited
Flavoproteins0.0133Inherited
BRCT domain0.01845Inherited
Triple coiled coil domain of C-type lectins0.02585Inherited
AraD/HMP-PK domain-like0.02585Inherited
Terpenoid cyclases/Protein prenyltransferases0.02882Inherited
TNF-like0.04141Inherited
C-type lectin-like0.04305Inherited
Integrin alpha N-terminal domain0.04466Inherited
Toll/Interleukin receptor TIR domain0.04466Inherited
(Trans)glycosidases0.04592Inherited
NAD kinase/diacylglycerol kinase-like0.04999Inherited
Ran binding protein zinc finger-like0.05437Inherited
A DNA-binding domain in eukaryotic transcription factors0.05437Inherited
PH domain-like0.05906Inherited
E2F-DP heterodimerization region0.06559Inherited
WWE domain0.06559Inherited
Nuclear receptor coactivator interlocking domain0.07087Inherited
CCCH zinc finger0.07777Inherited
SH3-domain0.09952Inherited
TIMP-like0.1124Inherited
4-helical cytokines0.1155Inherited
SH2 domain0.1674Inherited
Cyclin-like0.1775Inherited
Cysteine-rich domain0.1876Inherited
SMAD/FHA domain0.208Inherited
DBL homology domain (DH-domain)0.2302Inherited
SET domain0.2333Inherited
Nucleotidyltransferase0.2934Inherited
MHC antigen-recognition domain0.303Inherited
Nucleic acid-binding proteins0.303Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.3547Inherited
beta-beta-alpha zinc fingers0.3556Inherited
BAR/IMD domain-like0.4547Inherited
Protein kinase-like (PK-like)0.5034Inherited
Ankyrin repeat0.5175Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.5304Inherited
Calponin-homology domain, CH-domain0.5627Inherited
p53-like transcription factors0.6105Inherited
Bcl-2 inhibitors of programmed cell death0.6232Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.6444Inherited
Acyl-CoA N-acyltransferases (Nat)0.6881Inherited
DEATH domain0.6991Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.7314Inherited
Riboflavin synthase domain-like0.7314Inherited
Nuclear receptor ligand-binding domain0.7841Inherited
DNA/RNA polymerases0.9858Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    49562,51045
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 51045 - WW domain
  • 0Direct
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    57424,50494
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.0000003832Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0000008797Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.000004977Direct
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.001278Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.001278Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.003149Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.003594Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.003594Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.005482Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.0133Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.01677Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.01677Inherited
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0.02585Inherited
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.02585Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.02585Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.03117Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.05437Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.06559Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.07702Inherited
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 0.09285Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.1253Inherited
    57903,47370
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 0.1313Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.1644Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.1791Inherited
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.2772Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.3284Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.5484Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.5752Inherited
    56112,56112
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.6232Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.6232Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.681Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.7586Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.791Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.8373Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    57424,57424,50494
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.00001143Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.001278Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.01272Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.0133Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.01677Inherited
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.02585Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.03117Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.1108Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.2037Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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