SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Mammalian Phenotype (MP): abnormal blood cell morphology

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + 2:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(57|86) (66|47|21)
+ 1:   abnormal hematopoietic cell morphology [MP:0013656] <9>(48|77) (60|43|18)
0:   abnormal blood cell morphology [MP:0013657] <4>(31|49) (37|35|14)
- 1:   abnormal erythrocyte morphology [MP:0002447] <30>(6|12) (7|10|4)
- 1:   abnormal granulocyte morphology [MP:0002441] <6>(4|8) (6|6|2)
- 1:   abnormal platelet morphology [MP:0004720] <6>(1|3) (2|1|0)
- 1:   abnormal hemopoiesis [MP:0013693] <2>(25|34) (27|24|9)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
SPOC domain-like0Direct
PsbU/PolX domain-like0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
p53-like transcription factors0.00008713Direct
DNA polymerase beta, N-terminal domain-like0.004457Inherited
AraD/HMP-PK domain-like0.01462Inherited
Bcl-2 inhibitors of programmed cell death0.02367Inherited
E2F-DP heterodimerization region0.0316Inherited
SH2 domain0.035Inherited
Cyclin-like0.04734Inherited
SMAD/FHA domain0.07494Inherited
4-helical cytokines0.1336Inherited
Nucleotidyltransferase0.1441Inherited
A DNA-binding domain in eukaryotic transcription factors0.191Inherited
DNA/RNA polymerases0.1983Inherited
BRCT domain0.2496Inherited
BAR/IMD domain-like0.252Inherited
Integrin beta tail domain0.2897Inherited
Cysteine-rich domain0.2995Inherited
SET domain0.3231Inherited
TIMP-like0.4044Inherited
TNF receptor-like0.4286Inherited
Notch domain0.4428Inherited
DEATH domain0.5317Inherited
Terpenoid cyclases/Protein prenyltransferases0.628Inherited
Ankyrin repeat0.6297Inherited
DBL homology domain (DH-domain)0.6759Inherited
Calponin-homology domain, CH-domain0.7031Inherited
Protein kinase-like (PK-like)0.7329Inherited
SH3-domain0.8014Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
STAT DNA-binding domain0Direct
STAT0Direct
DNA polymerase beta-like0Direct
Transcription factor STAT-4 N-domain0Direct
DNA polymerase beta-like, second domain0Direct
RUNT domain0Direct
Short-chain cytokines0.00000004391Direct
Rel/Dorsal transcription factors, DNA-binding domain0.00009585Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0007321Direct
DNA polymerase beta, N-terminal domain-like0.003127Inherited
Erythroid transcription factor GATA-10.009244Inherited
Tissue inhibitor of metalloproteinases, TIMP0.01075Inherited
AraD-like aldolase/epimerase0.01075Inherited
E2F dimerization segment0.01103Inherited
Noncollagenous (NC1) domain of collagen IV0.01103Inherited
PLC-like (P variant)0.01588Inherited
Bcl-2 inhibitors of programmed cell death0.01846Inherited
SH2 domain0.03094Inherited
Cyclin0.03441Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.05025Inherited
DNA polymerase I0.06245Inherited
Eps15 homology domain (EH domain)0.06245Inherited
Cell cycle transcription factor e2f-dp0.07077Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.1017Inherited
Myb/SANT domain0.106Inherited
A DNA-binding domain in eukaryotic transcription factors0.167Inherited
Pleckstrin-homology domain (PH domain)0.2232Inherited
ets domain0.2259Inherited
Integrin beta EGF-like domains0.2618Inherited
Integrin beta tail domain0.2618Inherited
Pointed domain0.3287Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.3287Inherited
TNF receptor-like0.3473Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.3777Inherited
FHA domain0.3952Inherited
Notch domain0.4117Inherited
Interleukin-1 (IL-1)0.4117Inherited
MATH domain0.4117Inherited
V set domains (antibody variable domain-like)0.4895Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.5112Inherited
DEATH domain, DD0.5669Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.5814Inherited
Pyrin domain, PYD0.6023Inherited
Ankyrin repeat0.621Inherited
DBL homology domain (DH-domain)0.6589Inherited
Calponin-homology domain, CH-domain0.6846Inherited
Interleukin 17F, IL-17F0.6914Inherited
SH3-domain0.8015Inherited
Integrin domains0.8207Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
PsbU/PolX domain-like0Direct
STAT0Direct
SPOC domain-like0Direct
Transcription factor STAT-4 N-domain0Direct
p53-like transcription factors0.00004178Direct
DNA polymerase beta, N-terminal domain-like0.00264Inherited
AraD/HMP-PK domain-like0.009377Inherited
Bcl-2 inhibitors of programmed cell death0.01574Inherited
E2F-DP heterodimerization region0.02159Inherited
SH2 domain0.02409Inherited
Cyclin-like0.03335Inherited
SMAD/FHA domain0.05512Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.06397Inherited
beta-beta-alpha zinc fingers0.08715Inherited
4-helical cytokines0.1044Inherited
Nucleotidyltransferase0.1136Inherited
A DNA-binding domain in eukaryotic transcription factors0.1551Inherited
DNA/RNA polymerases0.1617Inherited
PH domain-like0.1783Inherited
BRCT domain0.2093Inherited
BAR/IMD domain-like0.2116Inherited
Integrin beta tail domain0.2471Inherited
Cysteine-rich domain0.2563Inherited
SET domain0.2788Inherited
TIMP-like0.3576Inherited
TNF receptor-like0.3817Inherited
Notch domain0.3953Inherited
DEATH domain0.4845Inherited
Acyl-CoA N-acyltransferases (Nat)0.5227Inherited
Terpenoid cyclases/Protein prenyltransferases0.5834Inherited
Ankyrin repeat0.5851Inherited
DBL homology domain (DH-domain)0.6338Inherited
Calponin-homology domain, CH-domain0.6623Inherited
Protein kinase-like (PK-like)0.694Inherited
SH3-domain0.7666Inherited
Integrin domains0.8006Inherited
C-type lectin-like0.9772Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    57424,50494
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.00007169Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0007133Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.0007133Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.0009039Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.009172Inherited
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0.009377Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.009377Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.01407Inherited
    56112,56112
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.01574Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.02159Inherited
    57903,47370
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 0.05614Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.06304Inherited
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.1343Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.1412Inherited
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 0.196Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.196Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.2471Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.2471Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.2471Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.2563Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.3128Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.3128Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.3149Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.4928Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.5146Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.6338Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9996Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57424,57424,50494
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.009377Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.03944Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.2471Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.3128Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.4851Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.6226Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)