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Mammalian Phenotype (MP): abnormal blood cell morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + 2:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(59|86) (66|47|21)
+ 1:   abnormal hematopoietic cell morphology [MP:0013656] <9>(50|77) (60|43|18)
0:   abnormal blood cell morphology [MP:0013657] <4>(31|49) (37|35|14)
- 1:   abnormal erythrocyte morphology [MP:0002447] <30>(6|12) (7|10|4)
- 1:   abnormal granulocyte morphology [MP:0002441] <6>(4|8) (6|6|2)
- 1:   abnormal platelet morphology [MP:0004720] <6>(1|3) (2|1|0)
- 1:   abnormal hemopoiesis [MP:0013693] <2>(25|34) (27|24|9)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SPOC domain-like0Direct
Transcription factor STAT-4 N-domain0Direct
PsbU/PolX domain-like0Direct
STAT0Direct
p53-like transcription factors0.00008696Direct
DNA polymerase beta, N-terminal domain-like0.004459Inherited
AraD/HMP-PK domain-like0.01461Inherited
E2F-DP heterodimerization region0.03159Inherited
SH2 domain0.03448Inherited
Bcl-2 inhibitors of programmed cell death0.03957Inherited
Cyclin-like0.04729Inherited
SMAD/FHA domain0.07491Inherited
4-helical cytokines0.1327Inherited
Nucleotidyltransferase0.1441Inherited
A DNA-binding domain in eukaryotic transcription factors0.1903Inherited
DNA/RNA polymerases0.1982Inherited
BAR/IMD domain-like0.2287Inherited
BRCT domain0.2486Inherited
Integrin beta tail domain0.289Inherited
Cysteine-rich domain0.2982Inherited
SET domain0.3217Inherited
TIMP-like0.403Inherited
TNF receptor-like0.4268Inherited
Notch domain0.4419Inherited
DEATH domain0.5293Inherited
Terpenoid cyclases/Protein prenyltransferases0.6267Inherited
Ankyrin repeat0.6272Inherited
DBL homology domain (DH-domain)0.674Inherited
Calponin-homology domain, CH-domain0.702Inherited
Protein kinase-like (PK-like)0.7292Inherited
SH3-domain0.7992Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
RUNT domain0Direct
STAT0Direct
STAT DNA-binding domain0Direct
Transcription factor STAT-4 N-domain0Direct
DNA polymerase beta-like0Direct
DNA polymerase beta-like, second domain0Direct
Short-chain cytokines0.00000004361Direct
Rel/Dorsal transcription factors, DNA-binding domain0.00009547Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0007339Direct
DNA polymerase beta, N-terminal domain-like0.003138Inherited
Erythroid transcription factor GATA-10.009259Inherited
AraD-like aldolase/epimerase0.01078Inherited
Tissue inhibitor of metalloproteinases, TIMP0.01078Inherited
E2F dimerization segment0.01105Inherited
Noncollagenous (NC1) domain of collagen IV0.01105Inherited
PLC-like (P variant)0.01588Inherited
SH2 domain0.03076Inherited
Bcl-2 inhibitors of programmed cell death0.0316Inherited
Cyclin0.03436Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.05023Inherited
Eps15 homology domain (EH domain)0.06244Inherited
DNA polymerase I0.06244Inherited
Cell cycle transcription factor e2f-dp0.0708Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.1016Inherited
Myb/SANT domain0.1059Inherited
A DNA-binding domain in eukaryotic transcription factors0.1669Inherited
Pleckstrin-homology domain (PH domain)0.2223Inherited
ets domain0.2256Inherited
Integrin beta EGF-like domains0.2613Inherited
Integrin beta tail domain0.2613Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.3281Inherited
Pointed domain0.3281Inherited
TNF receptor-like0.3465Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.3769Inherited
FHA domain0.3945Inherited
Notch domain0.4111Inherited
Interleukin-1 (IL-1)0.4111Inherited
MATH domain0.4111Inherited
V set domains (antibody variable domain-like)0.4881Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.5104Inherited
DEATH domain, DD0.5657Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.5807Inherited
Pyrin domain, PYD0.6017Inherited
Ankyrin repeat0.6196Inherited
DBL homology domain (DH-domain)0.6579Inherited
Calponin-homology domain, CH-domain0.684Inherited
Interleukin 17F, IL-17F0.6909Inherited
SH3-domain0.8001Inherited
Integrin domains0.82Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SPOC domain-like0Direct
Transcription factor STAT-4 N-domain0Direct
PsbU/PolX domain-like0Direct
STAT0Direct
p53-like transcription factors0.00004175Direct
DNA polymerase beta, N-terminal domain-like0.002643Inherited
AraD/HMP-PK domain-like0.009384Inherited
E2F-DP heterodimerization region0.02161Inherited
SH2 domain0.0237Inherited
Bcl-2 inhibitors of programmed cell death0.02745Inherited
Cyclin-like0.03335Inherited
SMAD/FHA domain0.05515Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.06339Inherited
beta-beta-alpha zinc fingers0.08596Inherited
4-helical cytokines0.1035Inherited
Nucleotidyltransferase0.1136Inherited
A DNA-binding domain in eukaryotic transcription factors0.1545Inherited
DNA/RNA polymerases0.1618Inherited
PH domain-like0.1761Inherited
BAR/IMD domain-like0.19Inherited
BRCT domain0.2085Inherited
Integrin beta tail domain0.2465Inherited
Cysteine-rich domain0.255Inherited
SET domain0.2777Inherited
TIMP-like0.3563Inherited
TNF receptor-like0.3801Inherited
Notch domain0.3945Inherited
DEATH domain0.4822Inherited
Acyl-CoA N-acyltransferases (Nat)0.5227Inherited
Terpenoid cyclases/Protein prenyltransferases0.5823Inherited
Ankyrin repeat0.5828Inherited
DBL homology domain (DH-domain)0.6322Inherited
Calponin-homology domain, CH-domain0.6612Inherited
Protein kinase-like (PK-like)0.6902Inherited
SH3-domain0.7644Inherited
Integrin domains0.7996Inherited
C-type lectin-like0.9767Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57424,50494
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0000716Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0007144Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.0007144Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.0009062Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.009174Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.009384Inherited
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0.009384Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.01407Inherited
    56112,56112
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.01575Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.02161Inherited
    57903,47370
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 0.05614Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.06304Inherited
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.1343Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.1398Inherited
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 0.1955Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.1955Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.2465Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.2465Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.2465Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.255Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.3121Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.3121Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.3129Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.4916Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.513Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.6322Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9995Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57424,57424,50494
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.009384Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.03945Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.2465Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.3121Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.4835Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.6202Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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