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Mammalian Phenotype (MP): abnormal myeloid cell morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + 2:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(58|86) (66|47|21)
+ 1:   abnormal hematopoietic cell morphology [MP:0013656] <9>(49|76) (60|43|18)
0:   abnormal myeloid cell morphology [MP:0013658] <8>(20|41) (26|23|8)
- 1:   abnormal myeloid cell number [MP:0013661] <6>(4|7) (4|2|0)
- 1:   abnormal platelet morphology [MP:0004720] <6>(1|3) (2|1|0)
- 1:   abnormal erythroid lineage cell morphology [MP:0013659] <5>(8|14) (9|12|6)
- 1:   abnormal myeloid leukocyte morphology [MP:0008250] <2>(11|24) (16|10|2)
- 1:   abnormal embryonic erythrocyte morphology [MP:0004230] <1>(0|0) (0|0|0)
- 1:   abnormal granulocyte monocyte progenitor cell morphology [MP:0013694] <1>(0|0) (0|0|0)
- 1:   abnormal megakaryocyte progenitor cell morphology [MP:0002413] <1>(2|3) (2|3|0)
- 1:   abnormal megakaryocyte-erythroid progenitor cell morphology [MP:0013702] <1>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Integrin beta tail domain0.0002288Direct
Flavoproteins0.003565Inherited
A DNA-binding domain in eukaryotic transcription factors0.009325Inherited
AraD/HMP-PK domain-like0.01163Inherited
Triple coiled coil domain of C-type lectins0.01163Inherited
p53-like transcription factors0.04824Inherited
TIMP-like0.09742Inherited
Nuclear receptor ligand-binding domain0.1181Inherited
Cyclin-like0.2396Inherited
Nucleic acid-binding proteins0.2411Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.2843Inherited
Riboflavin synthase domain-like0.2843Inherited
Transcription factor STAT-4 N-domain0.4355Inherited
STAT0.4355Inherited
Terpenoid cyclases/Protein prenyltransferases0.5239Inherited
BAR/IMD domain-like0.5619Inherited
PH domain-like0.6197Inherited
DEATH domain0.6816Inherited
TNF receptor-like0.9724Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
RUNT domain0Direct
Integrin beta tail domain0.0001441Direct
Integrin beta EGF-like domains0.0007135Direct
Erythroid transcription factor GATA-10.006489Inherited
A DNA-binding domain in eukaryotic transcription factors0.007064Inherited
Noncollagenous (NC1) domain of collagen IV0.008201Inherited
Tissue inhibitor of metalloproteinases, TIMP0.008412Inherited
AraD-like aldolase/epimerase0.008412Inherited
Triple coiled coil domain of C-type lectins0.008412Inherited
Cytochrome p450 reductase N-terminal domain-like0.008412Inherited
Long-chain cytokines0.01056Inherited
Tetraspanin0.02508Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.02508Inherited
NADPH-cytochrome p450 reductase-like0.02508Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.03582Inherited
Eps15 homology domain (EH domain)0.05053Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.07851Inherited
Nuclear receptor ligand-binding domain0.09905Inherited
Nuclear receptor0.09905Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.1052Inherited
Cyclin0.1052Inherited
Short-chain cytokines0.1327Inherited
Interferons/interleukin-10 (IL-10)0.1396Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.1857Inherited
PLC-like (P variant)0.2085Inherited
Myb/SANT domain0.2105Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.246Inherited
Enabled/VASP homology 1 domain (EVH1 domain)0.246Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.2621Inherited
beta-glycanases0.3272Inherited
Interleukin-1 (IL-1)0.3272Inherited
STAT0.4013Inherited
Transcription factor STAT-4 N-domain0.4013Inherited
STAT DNA-binding domain0.4013Inherited
Integrin domains0.4815Inherited
C2 set domains0.4901Inherited
Pyrin domain, PYD0.4901Inherited
Pointed domain0.5914Inherited
Interleukin 17F, IL-17F0.5914Inherited
TNF receptor-like0.7848Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Integrin beta tail domain0.000116Direct
Flavoproteins0.002089Inherited
A DNA-binding domain in eukaryotic transcription factors0.005802Inherited
Triple coiled coil domain of C-type lectins0.007364Inherited
AraD/HMP-PK domain-like0.007364Inherited
p53-like transcription factors0.03398Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.03685Inherited
TIMP-like0.07338Inherited
Nuclear receptor ligand-binding domain0.09102Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.1614Inherited
Cyclin-like0.2001Inherited
(Trans)glycosidases0.2015Inherited
Nucleic acid-binding proteins0.2015Inherited
Riboflavin synthase domain-like0.242Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.242Inherited
Transcription factor STAT-4 N-domain0.3881Inherited
STAT0.3881Inherited
Integrin domains0.4636Inherited
C-type lectin-like0.4738Inherited
Terpenoid cyclases/Protein prenyltransferases0.4765Inherited
BAR/IMD domain-like0.5154Inherited
PH domain-like0.5747Inherited
DEATH domain0.6398Inherited
TNF-like0.9162Inherited
TNF receptor-like0.9539Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.000116Direct
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.000116Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0004839Direct
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.007364Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.009081Inherited
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 0.01379Inherited
    57903,47370
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 0.04572Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.0493Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.09892Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.09892Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.1326Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.1335Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.1773Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.2365Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.2365Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.2365Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.3881Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.3881Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.3881Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.4122Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.5888Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.7167Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9893Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.000116Direct
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.03037Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.2365Inherited
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.3163Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.3163Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.3881Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.3881Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.51Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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