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Mammalian Phenotype (MP): abnormal hemopoiesis

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + 2:   abnormal hematopoietic cell morphology [MP:0013656] <9>(49|77) (60|43|18)
+ + 2:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(58|86) (66|47|21)
+ 1:   abnormal blood cell morphology/development [MP:0002429] <3>(26|35) (28|24|9)
+ 1:   abnormal blood cell morphology [MP:0013657] <4>(31|49) (37|35|14)
0:   abnormal hemopoiesis [MP:0013693] <2>(25|34) (27|24|9)
- 1:   abnormal definitive hematopoiesis [MP:0002123] <4>(24|34) (26|24|9)
- 1:   abnormal embryonic hematopoiesis [MP:0003396] <1>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SPOC domain-like0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
PsbU/PolX domain-like0Direct
SH2 domain0.00000001557Direct
p53-like transcription factors0.0002459Direct
DNA polymerase beta, N-terminal domain-like0.0004397Direct
Protein kinase-like (PK-like)0.0006455Direct
Cyclin-like0.001101Inherited
Bcl-2 inhibitors of programmed cell death0.002057Inherited
E2F-DP heterodimerization region0.00415Inherited
Notch domain0.007885Inherited
TNF receptor-like0.02812Inherited
Cysteine-rich domain0.03449Inherited
DNA/RNA polymerases0.04131Inherited
BRCT domain0.05943Inherited
SMAD/FHA domain0.06726Inherited
4-helical cytokines0.09073Inherited
DEATH domain0.1301Inherited
Nucleotidyltransferase0.1445Inherited
SH3-domain0.2552Inherited
SET domain0.2691Inherited
Ankyrin repeat0.3264Inherited
DBL homology domain (DH-domain)0.3398Inherited
Calponin-homology domain, CH-domain0.6938Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
STAT DNA-binding domain0Direct
RUNT domain0Direct
DNA polymerase beta-like0Direct
Transcription factor STAT-4 N-domain0Direct
STAT0Direct
DNA polymerase beta-like, second domain0Direct
SH2 domain0.00000001247Direct
DNA polymerase beta, N-terminal domain-like0.0002921Direct
E2F dimerization segment0.001188Inherited
Cyclin0.001254Inherited
Bcl-2 inhibitors of programmed cell death0.001498Inherited
DEATH domain, DD0.001669Inherited
Pointed domain0.003038Inherited
Notch domain0.005799Inherited
ets domain0.008414Inherited
Cell cycle transcription factor e2f-dp0.01064Inherited
DNA polymerase I0.01264Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.02232Inherited
Short-chain cytokines0.03243Inherited
TNF receptor-like0.04806Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.04806Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.04806Inherited
V set domains (antibody variable domain-like)0.0591Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.07008Inherited
MATH domain0.0883Inherited
Myb/SANT domain0.1011Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.104Inherited
PLC-like (P variant)0.1373Inherited
Pleckstrin-homology domain (PH domain)0.2244Inherited
SH3-domain0.241Inherited
FHA domain0.2817Inherited
DBL homology domain (DH-domain)0.3143Inherited
Ankyrin repeat0.3253Inherited
Calponin-homology domain, CH-domain0.6884Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SPOC domain-like0Direct
PsbU/PolX domain-like0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
SH2 domain0.000000005928Direct
p53-like transcription factors0.0001253Direct
DNA polymerase beta, N-terminal domain-like0.0002306Direct
Protein kinase-like (PK-like)0.0003452Direct
Cyclin-like0.0006053Direct
Bcl-2 inhibitors of programmed cell death0.001171Inherited
E2F-DP heterodimerization region0.002454Inherited
Notch domain0.004845Inherited
TNF receptor-like0.019Inherited
Cysteine-rich domain0.02369Inherited
DNA/RNA polymerases0.02875Inherited
BRCT domain0.04274Inherited
SMAD/FHA domain0.04897Inherited
beta-beta-alpha zinc fingers0.05013Inherited
4-helical cytokines0.06779Inherited
DEATH domain0.1012Inherited
Nucleotidyltransferase0.1139Inherited
SH3-domain0.2145Inherited
SET domain0.2276Inherited
Ankyrin repeat0.2821Inherited
DBL homology domain (DH-domain)0.2948Inherited
Acyl-CoA N-acyltransferases (Nat)0.4378Inherited
Calponin-homology domain, CH-domain0.6525Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.00002838Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.00003414Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.0002066Direct
    56112,56112
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.001171Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.001171Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.001422Inherited
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0.001422Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.002454Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0034Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.0034Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.007628Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.02933Inherited
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.03013Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.06307Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.09605Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.1139Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.2948Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.001422Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0285Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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