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Mammalian Phenotype (MP): abnormal classified tumor incidence

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   neoplasm [MP:0002006] <2>(32|37) (38|18|7)
+ + 2:   altered tumor susceptibility [MP:0002166] <3>(25|29) (30|11|3)
+ 1:   abnormal tumor incidence [MP:0002019] <6>(25|29) (30|11|3)
0:   abnormal classified tumor incidence [MP:0020188] <3>(20|19) (26|7|1)
- 1:   increased classified tumor incidence [MP:0010273] <19>(20|19) (26|7|1)
- 1:   decreased classified tumor incidence [MP:0010283] <5>(0|0) (0|0|0)
- 1:   abnormal adenoma incidence [MP:0020189] <2>(3|2) (4|1|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
SMAD MH1 domain0.0000025Direct
Nucleic acid-binding proteins0.0001059Direct
SMAD/FHA domain0.0001775Direct
DNA-glycosylase0.0004843Direct
SPOC domain-like0.0004843Direct
DNA repair protein MutS, domain III0.001664Inherited
Notch domain0.001664Inherited
SAND domain-like0.001664Inherited
BRCT domain0.006653Inherited
Putative DNA-binding domain0.006833Inherited
CCCH zinc finger0.03844Inherited
SET domain0.04139Inherited
Cyclin-like0.1856Inherited
p53-like transcription factors0.1856Inherited
DNA/RNA polymerases0.2296Inherited
ARM repeat0.3754Inherited
Intermediate filament protein, coiled coil region0.4413Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.5205Inherited
Ubiquitin-like0.6933Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
p53 DNA-binding domain-like0Direct
p53 tetramerization domain0Direct
SMAD domain0.000001779Direct
SMAD MH1 domain0.000001779Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0.000001779Direct
DNA polymerase I0.0001535Direct
Notch domain0.001209Inherited
DNA repair protein MutS, domain III0.001209Inherited
Forkhead DNA-binding domain0.001464Inherited
p120GAP domain-like0.002802Inherited
Single strand DNA-binding domain, SSB0.005283Inherited
Histone lysine methyltransferases0.01454Inherited
CCCH zinc finger0.03214Inherited
FHA domain0.0496Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.1511Inherited
DnaQ-like 3'-5' exonuclease0.3915Inherited
Phosphotyrosine-binding domain (PTB)0.4028Inherited
Intermediate filament protein, coiled coil region0.4362Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
SMAD MH1 domain0.000001043Direct
Nucleic acid-binding proteins0.00005135Direct
SMAD/FHA domain0.00008914Direct
SPOC domain-like0.000255Direct
DNA-glycosylase0.000255Direct
Chromo domain-like0.0008233Direct
DNA repair protein MutS, domain III0.0009371Direct
Notch domain0.0009371Direct
SAND domain-like0.0009371Direct
BRCT domain0.004059Inherited
Putative DNA-binding domain0.004182Inherited
CCCH zinc finger0.0266Inherited
SET domain0.02882Inherited
Cysteine-rich domain0.1181Inherited
Cyclin-like0.1503Inherited
p53-like transcription factors0.1503Inherited
DNA/RNA polymerases0.1908Inherited
Ribonuclease H-like0.2414Inherited
ARM repeat0.3294Inherited
Intermediate filament protein, coiled coil region0.3938Inherited
Snake toxin-like0.4157Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.4731Inherited
4-helical cytokines0.4822Inherited
Ubiquitin-like0.6521Inherited
Leucine zipper domain0.6942Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.000255Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0009371Direct
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.006817Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.006955Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.05361Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.3892Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.03364Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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