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Mammalian Phenotype (MP): abnormal classified tumor incidence

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   neoplasm [MP:0002006] <2>(32|37) (38|18|7)
+ + 2:   altered tumor susceptibility [MP:0002166] <3>(25|29) (30|11|3)
+ 1:   abnormal tumor incidence [MP:0002019] <6>(25|29) (30|11|3)
0:   abnormal classified tumor incidence [MP:0020188] <3>(20|19) (26|7|1)
- 1:   increased classified tumor incidence [MP:0010273] <19>(20|19) (26|7|1)
- 1:   decreased classified tumor incidence [MP:0010283] <5>(0|0) (0|0|0)
- 1:   abnormal adenoma incidence [MP:0020189] <2>(3|2) (4|1|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
SMAD MH1 domain0.000002489Direct
Nucleic acid-binding proteins0.0001054Direct
SMAD/FHA domain0.000177Direct
DNA-glycosylase0.0004835Direct
SPOC domain-like0.0004835Direct
SAND domain-like0.001662Inherited
DNA repair protein MutS, domain III0.001662Inherited
Notch domain0.001662Inherited
BRCT domain0.006641Inherited
Putative DNA-binding domain0.006829Inherited
CCCH zinc finger0.0384Inherited
SET domain0.04134Inherited
p53-like transcription factors0.1856Inherited
Cyclin-like0.1856Inherited
DNA/RNA polymerases0.2297Inherited
ARM repeat0.3754Inherited
Intermediate filament protein, coiled coil region0.4409Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.5206Inherited
Ubiquitin-like0.6933Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
Retinoblastoma tumor suppressor domains0Direct
p53 tetramerization domain0Direct
SMAD domain0.000001771Direct
SMAD MH1 domain0.000001771Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0.000001771Direct
DNA polymerase I0.000153Direct
Notch domain0.0012Inherited
DNA repair protein MutS, domain III0.0012Inherited
Forkhead DNA-binding domain0.001453Inherited
p120GAP domain-like0.002786Inherited
Single strand DNA-binding domain, SSB0.005257Inherited
Histone lysine methyltransferases0.01448Inherited
CCCH zinc finger0.03203Inherited
FHA domain0.04944Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.151Inherited
DnaQ-like 3'-5' exonuclease0.3914Inherited
Phosphotyrosine-binding domain (PTB)0.4193Inherited
Intermediate filament protein, coiled coil region0.4357Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
SMAD MH1 domain0.00000104Direct
Nucleic acid-binding proteins0.00005116Direct
SMAD/FHA domain0.00008887Direct
SPOC domain-like0.0002547Direct
DNA-glycosylase0.0002547Direct
Chromo domain-like0.0008206Direct
DNA repair protein MutS, domain III0.0009359Direct
Notch domain0.0009359Direct
SAND domain-like0.0009359Direct
BRCT domain0.004048Inherited
Putative DNA-binding domain0.004176Inherited
CCCH zinc finger0.02656Inherited
SET domain0.02878Inherited
Cysteine-rich domain0.1181Inherited
p53-like transcription factors0.1503Inherited
Cyclin-like0.1503Inherited
DNA/RNA polymerases0.1908Inherited
Ribonuclease H-like0.2414Inherited
ARM repeat0.3294Inherited
Intermediate filament protein, coiled coil region0.3934Inherited
Snake toxin-like0.4157Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.4731Inherited
4-helical cytokines0.4821Inherited
Ubiquitin-like0.6521Inherited
Leucine zipper domain0.6942Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.0002547Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0009359Direct
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.006806Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.006947Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.05355Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.389Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.03359Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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