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Worm Phenotype (WP): organism metabolism processing variant

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Variant [WBPhenotype:0000886] <5>
+ + + 3:   physiology variant [WBPhenotype:0000519] <6>(490|567) (491|248|69)
+ + 2:   organism physiology variant [WBPhenotype:0000576] <10>(359|429) (362|200|61)
+ 1:   organism homeostasis metabolism variant [WBPhenotype:0000577] <17>(347|416) (351|198|60)
0:   organism metabolism processing variant [WBPhenotype:0000027] <24>(170|181) (176|83|25)
- 1:   gene expression variant [WBPhenotype:0000717] <10>(119|131) (125|62|19)
- 1:   lipid metabolism variant [WBPhenotype:0000725] <8>(19|24) (20|8|4)
- 1:   metabolic pathway variant [WBPhenotype:0000463] <8>(30|26) (30|13|8)
- 1:   enzyme activity variant [WBPhenotype:0000727] <5>(6|6) (6|1|0)
- 1:   neurotransmitter metabolism variant [WBPhenotype:0000221] <4>(0|0) (0|0|0)
- 1:   protein interaction variant [WBPhenotype:0001369] <3>(47|48) (48|21|9)
- 1:   ATP levels variant [WBPhenotype:0001574] <2>(2|2) (2|1|0)
- 1:   biogenic amine physiology variant [WBPhenotype:0001518] <2>(0|0) (0|0|0)
- 1:   energy expenditure variant [WBPhenotype:0001835] <1>(0|0) (0|0|0)
- 1:   glutathione levels variant [WBPhenotype:0001899] <1>(1|1) (1|0|0)
- 1:   neuropeptide metabolism variant [WBPhenotype:0001757] <1>(0|0) (0|0|0)
- 1:   post translational processing variant [WBPhenotype:0000122] <1>(0|0) (0|0|0)
- 1:   GABA levels variant [WBPhenotype:0000552](0|0) (0|0|0)
- 1:   acetylcholine levels variant [WBPhenotype:0000507](0|0) (0|0|0)
- 1:   carbohydrate metabolism variant [WBPhenotype:0002072](0|0) (0|0|0)
- 1:   dietary sugar response variant [WBPhenotype:0002273](0|0) (0|0|0)
- 1:   galactose metabolism variant [WBPhenotype:0002206](0|0) (0|0|0)
- 1:   glucose intolerant [WBPhenotype:0002400](0|0) (0|0|0)
- 1:   glycation variant [WBPhenotype:0002008](0|0) (0|0|0)
- 1:   glycogen levels variant [WBPhenotype:0001892](0|0) (0|0|0)
- 1:   hormone metabolism variant [WBPhenotype:0001843](0|0) (0|0|0)
- 1:   hypersensitive to galactose [WBPhenotype:0002205](0|0) (0|0|0)
- 1:   nonsense mRNA accumulation [WBPhenotype:0000508](2|1) (2|0|0)
- 1:   pheromone production variant [WBPhenotype:0002381](0|0) (0|0|0)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
LDH C-terminal domain-like0Direct
Clathrin adaptor appendage domain0Direct
Restriction endonuclease-like0Direct
Ribosomal proteins S24e, L23 and L15e0Direct
TK C-terminal domain-like0Direct
GroEL-intermediate domain like0Direct
Tubulin nucleotide-binding domain-like0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
F1F0 ATP synthase subunit C0Direct
Ribosomal protein L10Direct
ISP domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
MIR domain0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
Cullin homology domain0Direct
FF domain0Direct
SMAD MH1 domain0Direct
Zn-finger domain of Sec23/240Direct
L-aspartase-like0Direct
LEM domain0Direct
JAB1/MPN domain0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Oxysterol-binding protein-like0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
HSP90 C-terminal domain0Direct
Heme-dependent catalase-like0Direct
Class II aaRS ABD-related0Direct
S-adenosylmethionine synthetase0Direct
Tubulin C-terminal domain-like0Direct
Cu,Zn superoxide dismutase-like0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Nop domain0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Ribosomal protein L10-like0Direct
14-3-3 protein0Direct
GroEL apical domain-like0Direct
Helical domain of Sec23/240Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
GroEL equatorial domain-like0Direct
RING/U-box0.000000000000005335Direct
ARM repeat0.000000000001245Direct
Cysteine proteinases0.0000000002984Direct
WD40 repeat-like0.000000001474Direct
Histone-fold0.00000001701Direct
P-loop containing nucleoside triphosphate hydrolases0.00000005791Direct
UBC-like0.0000001243Direct
Homeodomain-like0.0000002158Direct
"Winged helix" DNA-binding domain0.0000002315Direct
HSP20-like chaperones0.0000007325Direct
RNA-binding domain, RBD0.000001458Direct
Chaperone J-domain0.00000161Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.000001713Direct
Acyl-CoA dehydrogenase NM domain-like0.000001713Direct
PH domain-like0.00001377Direct
Class II aaRS and biotin synthetases0.0000211Direct
SNARE-like0.00002647Direct
beta-beta-alpha zinc fingers0.00003671Direct
Nucleotidylyl transferase0.00008249Direct
Thiolase-like0.00008912Direct
HLH, helix-loop-helix DNA-binding domain0.0001362Direct
Translation proteins SH3-like domain0.0001843Direct
Translation proteins0.0001853Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0002229Direct
PAP/OAS1 substrate-binding domain0.0002418Direct
Actin-like ATPase domain0.0002811Direct
Ubiquitin-like0.0003025Direct
Acid proteases0.0003387Direct
Nucleotidyltransferase0.000395Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.0005542Direct
Arginase/deacetylase0.0005542Direct
Hect, E3 ligase catalytic domain0.0005542Direct
Cullin repeat-like0.0005542Direct
B-box zinc-binding domain0.00056Direct
Cysteine-rich domain0.0007765Direct
CCCH zinc finger0.001073Inherited
Cyclophilin-like0.001242Inherited
PYP-like sensor domain (PAS domain)0.001376Inherited
Sm-like ribonucleoproteins0.002908Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.004211Inherited
HMG-box0.004423Inherited
ClpP/crotonase0.004423Inherited
CoA-dependent acyltransferases0.005952Inherited
Nucleic acid-binding proteins0.006105Inherited
ENTH/VHS domain0.006996Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.007269Inherited
DEATH domain0.007269Inherited
Calpain large subunit, middle domain (domain III)0.007526Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.007526Inherited
Riboflavin synthase domain-like0.007526Inherited
beta and beta-prime subunits of DNA dependent RNA-polymerase0.008183Inherited
Sec1/munc18-like (SM) proteins0.008183Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.008626Inherited
FKBP-like0.009783Inherited
Intermediate filament protein, coiled coil region0.01076Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.01076Inherited
Frizzled cysteine-rich domain0.01115Inherited
Lipocalins0.01189Inherited
Galactose-binding domain-like0.01201Inherited
GST C-terminal domain-like0.01382Inherited
PAZ domain0.01394Inherited
Activating enzymes of the ubiquitin-like proteins0.01582Inherited
Saposin0.01663Inherited
Leucine zipper domain0.01802Inherited
Seven-hairpin glycosidases0.01809Inherited
DHS-like NAD/FAD-binding domain0.02172Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.02916Inherited
MIT domain0.02993Inherited
ADC-like0.02993Inherited
Ribosomal protein S5 domain 2-like0.03136Inherited
Zn-binding ribosomal proteins0.0337Inherited
SH3-domain0.03485Inherited
L30e-like0.04303Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.04558Inherited
Cdc48 domain 2-like0.04682Inherited
Integrin domains0.04682Inherited
WWE domain0.04682Inherited
Single hybrid motif0.04873Inherited
Spectrin repeat0.04873Inherited
Lamin A/C globular tail domain0.04873Inherited
DBL homology domain (DH-domain)0.05461Inherited
p53-like transcription factors0.05521Inherited
FYVE/PHD zinc finger0.05706Inherited
UBA-like0.06939Inherited
Ferritin-like0.07034Inherited
SET domain0.07167Inherited
Acetyl-CoA synthetase-like0.0718Inherited
Transducin (alpha subunit), insertion domain0.08156Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.08457Inherited
S15/NS1 RNA-binding domain0.09579Inherited
Cyclin-like0.1053Inherited
GTPase activation domain, GAP0.1144Inherited
Growth factor receptor domain0.1171Inherited
Calcium ATPase, transmembrane domain M0.1231Inherited
FAD/NAD(P)-binding domain0.1292Inherited
HSP40/DnaJ peptide-binding domain0.1411Inherited
Tubby C-terminal domain-like0.1411Inherited
ARID-like0.1411Inherited
CAD & PB1 domains0.1411Inherited
t-snare proteins0.1535Inherited
Thiamin diphosphate-binding fold (THDP-binding)0.1535Inherited
Thioredoxin-like0.1552Inherited
KA1-like0.1903Inherited
Quinoprotein alcohol dehydrogenase-like0.1917Inherited
Fibronectin type III0.1929Inherited
Calponin-homology domain, CH-domain0.1966Inherited
dsRNA-binding domain-like0.2035Inherited
cAMP-binding domain-like0.2163Inherited
EF-hand0.2198Inherited
Eukaryotic type KH-domain (KH-domain type I)0.2293Inherited
DNA/RNA polymerases0.2723Inherited
Nuclear receptor ligand-binding domain0.5704Inherited
Protein kinase-like (PK-like)0.5969Inherited
SH2 domain0.5988Inherited
Second domain of FERM0.6679Inherited
Periplasmic binding protein-like II0.7166Inherited
Skp1 dimerisation domain-like0.7631Inherited
Chromo domain-like0.8067Inherited
Immunoglobulin0.9224Inherited
Ribonuclease H-like0.9337Inherited
POZ domain1Inherited
alpha/beta-Hydrolases1Inherited
Nucleotide cyclase1Inherited
F-box domain1Inherited
Neurotransmitter-gated ion-channel transmembrane pore1Inherited
Periplasmic binding protein-like I1Inherited
PapD-like1Inherited
RNI-like1Inherited
Voltage-gated potassium channels1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Mammalian PLC0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Anticodon-binding domain of Class II aaRS0Direct
Trunk domain of Sec23/240Direct
Cullin repeat0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Acyl-carrier protein (ACP)0Direct
Zn-finger domain of Sec23/240Direct
S-adenosylmethionine synthetase0Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0Direct
14-3-3 protein0Direct
Group II chaperonin (CCT, TRIC), ATPase domain0Direct
Nop domain0Direct
MIR domain0Direct
RecA protein-like (ATPase-domain)0Direct
XPF/Rad1/Mus81 nuclease0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Oxysterol-binding protein0Direct
Hsp90 middle domain0Direct
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
LEM domain0Direct
POU-specific domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
RNA-polymerase beta0Direct
Integrin domains0Direct
Sir2 family of transcriptional regulators0Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
FF domain0Direct
Ribonucleotide reductase-like0Direct
DEATH domain, DD0Direct
Group II chaperonin (CCT, TRIC), apical domain0Direct
Clathrin adaptor core protein0Direct
Proteasome subunits0Direct
Adenain-like0Direct
SCF ubiquitin ligase complex WHB domain0Direct
Cullin homology domain0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
p120GAP domain-like0Direct
LDH N-terminal domain-like0Direct
Histone deacetylase, HDAC0Direct
Brix domain0Direct
Quinoprotein alcohol dehydrogenase-like0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
F1F0 ATP synthase subunit C0Direct
Lactate & malate dehydrogenases, C-terminal domain0Direct
ets domain0Direct
Lesion bypass DNA polymerase (Y-family), catalytic domain0Direct
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain0Direct
Ribosomal protein L10Direct
L30e/L7ae ribosomal proteins0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
HCDH C-domain-like0Direct
MIF4G domain-like0Direct
HSP90 C-terminal domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Helical domain of Sec23/240Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
CAT-like0Direct
beta-sandwich domain of Sec23/240Direct
a tRNA synthase domain0Direct
Heme-dependent catalases0Direct
Erythroid transcription factor GATA-10Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain0Direct
RNA editing terminal uridyl transferase 2, RET2, domain 20Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Tubulin, GTPase domain0Direct
SMAD MH1 domain0Direct
Cu,Zn superoxide dismutase-like0Direct
Tubulin, C-terminal domain0Direct
PDI-like0Direct
Clathrin coat assembly domain0Direct
Homeodomain0.0000004797Direct
UBC-related0.0000006208Direct
Nucleosome core histones0.0000008006Direct
Actin/HSP700.000005474Direct
Pepsin-like0.000005658Direct
G proteins0.0000187Direct
Ubiquitin carboxyl-terminal hydrolase, UCH0.00002376Direct
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.00003276Direct
Pleckstrin-homology domain (PH domain)0.00003433Direct
Chaperone J-domain0.00003993Direct
RING finger domain, C3HC40.00004219Direct
Dual specificity phosphatase-like0.0001517Direct
Fatty acid binding protein-like0.0001633Direct
Papain-like0.0002585Direct
WD40-repeat0.0002628Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.0003251Direct
PLC-like (P variant)0.0003532Direct
Tetratricopeptide repeat (TPR)0.0004442Direct
Canonical RBD0.0005782Direct
Ubiquitin-related0.0005813Direct
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.0006473Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.0006889Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0007611Direct
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.001058Inherited
Thiolase-related0.001636Inherited
HSP200.001636Inherited
Hect, E3 ligase catalytic domain0.001636Inherited
HLH, helix-loop-helix DNA-binding domain0.001902Inherited
Armadillo repeat0.002314Inherited
B-box zinc-binding domain0.002973Inherited
Translational machinery components0.003523Inherited
SMAD domain0.003523Inherited
Heat shock protein 70kD (HSP70), peptide-binding domain0.003523Inherited
Cyclophilin (peptidylprolyl isomerase)0.005632Inherited
CCCH zinc finger0.007175Inherited
acyl-CoA oxidase C-terminal domains0.007503Inherited
acyl-CoA oxidase N-terminal domains0.007503Inherited
Histone lysine methyltransferases0.01225Inherited
Sec1/munc18-like (SM) proteins0.01596Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP0.01604Inherited
Gastric lipase0.01715Inherited
Calpain large subunit, middle domain (domain III)0.01715Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.01737Inherited
EF-hand modules in multidomain proteins0.02013Inherited
Frizzled cysteine-rich domain0.02013Inherited
Transforming growth factor (TGF)-beta0.02013Inherited
Glutathione S-transferase (GST), N-terminal domain0.023Inherited
Extended AAA-ATPase domain0.02412Inherited
FKBP immunophilin/proline isomerase0.02431Inherited
LIM domain0.02431Inherited
Intermediate filament protein, coiled coil region0.02756Inherited
Ubiquitin activating enzymes (UBA)0.03372Inherited
Class I alpha-1;2-mannosidase, catalytic domain0.03583Inherited
Crotonase-like0.0371Inherited
MIT domain0.04696Inherited
Bacterial lipase0.04696Inherited
Cdc48 N-terminal domain-like0.04696Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.04875Inherited
Elongation factors0.05332Inherited
Extended PAW domain0.05332Inherited
Pumilio repeat0.05427Inherited
Choline/Carnitine O-acyltransferase0.05427Inherited
PDZ domain0.06191Inherited
PAZ domain0.06363Inherited
Leucine zipper domain0.06534Inherited
Cold shock DNA-binding domain-like0.06609Inherited
Cdc48 domain 2-like0.07058Inherited
WWE domain0.07058Inherited
Anticodon-binding domain0.07058Inherited
6-phosphogluconate dehydrogenase-like, N-terminal domain0.07345Inherited
Lamin A/C globular tail domain0.08448Inherited
Glutathione S-transferase (GST), C-terminal domain0.08871Inherited
Biotinyl/lipoyl-carrier proteins and domains0.1018Inherited
Spectrin repeat0.1628Inherited
GABA-aminotransferase-like0.1645Inherited
SH3-domain0.1963Inherited
Cyclin0.2Inherited
DEP domain0.2036Inherited
Transducin (alpha subunit), insertion domain0.2067Inherited
Acetyl-CoA synthetase-like0.2108Inherited
t-snare proteins0.2515Inherited
cAMP-binding domain0.2684Inherited
PHD domain0.2756Inherited
I set domains0.2879Inherited
First domain of FERM0.3656Inherited
Calmodulin-like0.3762Inherited
Calponin-homology domain, CH-domain0.42Inherited
Fibronectin type III0.486Inherited
Calpain large subunit, catalytic domain (domain II)0.5915Inherited
Synaptotagmin-like (S variant)0.6234Inherited
Third domain of FERM0.6361Inherited
Phosphate binding protein-like0.7162Inherited
BCR-homology GTPase activation domain (BH-domain)0.7514Inherited
Second domain of FERM0.7766Inherited
N-acetyl transferase, NAT0.7788Inherited
Double-stranded RNA-binding domain (dsRBD)0.8707Inherited
SH2 domain0.9382Inherited
Nuclear receptor ligand-binding domain0.9765Inherited
Skp1 dimerisation domain-like0.991Inherited
F-box domain1Inherited
Protein kinases, catalytic subunit1Inherited
BTB/POZ domain1Inherited
MSP-like1Inherited
Acetylcholinesterase-like1Inherited
Voltage-gated potassium channels1Inherited
Nuclear receptor1Inherited
Adenylyl and guanylyl cyclase catalytic domain1Inherited


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Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Ribosomal proteins S24e, L23 and L15e0Direct
Ribosomal protein L10Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
F1F0 ATP synthase subunit C0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
MIR domain0Direct
FF domain0Direct
Ribosomal protein L10-like0Direct
GroEL equatorial domain-like0Direct
L-aspartase-like0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Clathrin adaptor appendage domain0Direct
Oxysterol-binding protein-like0Direct
JAB1/MPN domain0Direct
Class II aaRS ABD-related0Direct
Nop domain0Direct
Helical domain of Sec23/240Direct
Restriction endonuclease-like0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
TK C-terminal domain-like0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
Cullin homology domain0Direct
Zn-finger domain of Sec23/240Direct
GroEL-intermediate domain like0Direct
ISP domain0Direct
HSP90 C-terminal domain0Direct
Cu,Zn superoxide dismutase-like0Direct
ValRS/IleRS/LeuRS editing domain0Direct
14-3-3 protein0Direct
Heme-dependent catalase-like0Direct
SMAD MH1 domain0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Tubulin nucleotide-binding domain-like0Direct
GroEL apical domain-like0Direct
Tubulin C-terminal domain-like0Direct
S-adenosylmethionine synthetase0Direct
LEM domain0Direct
LDH C-terminal domain-like0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
RING/U-box0.000000000000004153Direct
ARM repeat0.0000000000009747Direct
Cysteine proteinases0.0000000002353Direct
WD40 repeat-like0.000000001165Direct
Histone-fold0.0000000135Direct
P-loop containing nucleoside triphosphate hydrolases0.00000004611Direct
UBC-like0.00000009911Direct
Homeodomain-like0.0000001724Direct
"Winged helix" DNA-binding domain0.0000001851Direct
HSP20-like chaperones0.0000005882Direct
RNA-binding domain, RBD0.000001174Direct
Chaperone J-domain0.000001296Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.00000138Direct
Acyl-CoA dehydrogenase NM domain-like0.00000138Direct
PH domain-like0.00001115Direct
Class II aaRS and biotin synthetases0.00001711Direct
SNARE-like0.00002148Direct
beta-beta-alpha zinc fingers0.0000298Direct
Nucleotidylyl transferase0.00006718Direct
Thiolase-like0.00007261Direct
HLH, helix-loop-helix DNA-binding domain0.0001112Direct
Translation proteins SH3-like domain0.0001505Direct
Translation proteins0.0001513Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0001822Direct
PAP/OAS1 substrate-binding domain0.0001978Direct
Actin-like ATPase domain0.0002302Direct
Ubiquitin-like0.0002478Direct
Acid proteases0.0002777Direct
Nucleotidyltransferase0.0003244Direct
Hect, E3 ligase catalytic domain0.0004562Direct
Arginase/deacetylase0.0004562Direct
Cullin repeat-like0.0004562Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.0004562Direct
B-box zinc-binding domain0.0004611Direct
Cysteine-rich domain0.0006414Direct
CCCH zinc finger0.0008883Direct
Cyclophilin-like0.00103Inherited
PYP-like sensor domain (PAS domain)0.001142Inherited
Sm-like ribonucleoproteins0.002442Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.003552Inherited
ClpP/crotonase0.003737Inherited
HMG-box0.003737Inherited
CoA-dependent acyltransferases0.005046Inherited
Nucleic acid-binding proteins0.005177Inherited
ENTH/VHS domain0.005943Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.006177Inherited
DEATH domain0.006177Inherited
Riboflavin synthase domain-like0.006401Inherited
Calpain large subunit, middle domain (domain III)0.006401Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.006401Inherited
Sec1/munc18-like (SM) proteins0.006971Inherited
beta and beta-prime subunits of DNA dependent RNA-polymerase0.006971Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.007356Inherited
FKBP-like0.008356Inherited
Intermediate filament protein, coiled coil region0.009206Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.009206Inherited
Frizzled cysteine-rich domain0.009546Inherited
Lipocalins0.0102Inherited
Galactose-binding domain-like0.0103Inherited
GST C-terminal domain-like0.01189Inherited
PAZ domain0.01199Inherited
Activating enzymes of the ubiquitin-like proteins0.01364Inherited
Saposin0.01434Inherited
Leucine zipper domain0.01557Inherited
Seven-hairpin glycosidases0.01563Inherited
DHS-like NAD/FAD-binding domain0.01886Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.02546Inherited
MIT domain0.02614Inherited
ADC-like0.02614Inherited
Ribosomal protein S5 domain 2-like0.0274Inherited
Zn-binding ribosomal proteins0.02949Inherited
SH3-domain0.03051Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.03723Inherited
Lipovitellin-phosvitin complex, superhelical domain0.03723Inherited
L30e-like0.03782Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.04011Inherited
Integrin domains0.04123Inherited
Cdc48 domain 2-like0.04123Inherited
WWE domain0.04123Inherited
Lamin A/C globular tail domain0.04297Inherited
Spectrin repeat0.04297Inherited
Single hybrid motif0.04297Inherited
DBL homology domain (DH-domain)0.04828Inherited
p53-like transcription factors0.04883Inherited
FYVE/PHD zinc finger0.05051Inherited
UBA-like0.06169Inherited
Translational machinery components0.06255Inherited
Ferritin-like0.06255Inherited
SET domain0.06376Inherited
Acetyl-CoA synthetase-like0.06389Inherited
Transducin (alpha subunit), insertion domain0.07282Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.07562Inherited
S15/NS1 RNA-binding domain0.08595Inherited
Cyclin-like0.09472Inherited
GTPase activation domain, GAP0.1032Inherited
Growth factor receptor domain0.1057Inherited
Calcium ATPase, transmembrane domain M0.1114Inherited
FAD/NAD(P)-binding domain0.1171Inherited
ARID-like0.1282Inherited
CAD & PB1 domains0.1282Inherited
HSP40/DnaJ peptide-binding domain0.1282Inherited
Tubby C-terminal domain-like0.1282Inherited
Thiamin diphosphate-binding fold (THDP-binding)0.1399Inherited
t-snare proteins0.1399Inherited
Thioredoxin-like0.1414Inherited
KA1-like0.1745Inherited
Osmotin, thaumatin-like protein0.1745Inherited
Quinoprotein alcohol dehydrogenase-like0.1758Inherited
Fibronectin type III0.1769Inherited
Calponin-homology domain, CH-domain0.1805Inherited
dsRNA-binding domain-like0.1871Inherited
cAMP-binding domain-like0.1993Inherited
EF-hand0.2027Inherited
Eukaryotic type KH-domain (KH-domain type I)0.2118Inherited
DNA/RNA polymerases0.2532Inherited
Insulin-like0.3001Inherited
PDZ domain-like0.4025Inherited
Nuclear receptor ligand-binding domain0.5478Inherited
Protein kinase-like (PK-like)0.5745Inherited
SH2 domain0.5763Inherited
Second domain of FERM0.6465Inherited
Periplasmic binding protein-like II0.6964Inherited
Skp1 dimerisation domain-like0.7442Inherited
Chromo domain-like0.7895Inherited
Immunoglobulin0.91Inherited
Ribonuclease H-like0.9216Inherited
Periplasmic binding protein-like I0.998Inherited
alpha/beta-Hydrolases1Inherited
POZ domain1Inherited
Neurotransmitter-gated ion-channel transmembrane pore1Inherited
F-box domain1Inherited
Nucleotide cyclase1Inherited
Voltage-gated potassium channels1Inherited
RNI-like1Inherited
PapD-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    81383,50978
  • 81383 - F-box domain
  • 50978 - WD40 repeat-like
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    52518,52922
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 0Direct
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    64356,49447
  • 64356 - SNARE-like
  • 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor
  • 0Direct
    46785,46785
  • 46785 - "Winged helix" DNA-binding domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    81698,81698
  • 81698 - FF domain
  • 81698 - FF domain
  • 0Direct
    51735,56327
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 56327 - LDH C-terminal domain-like
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    51905,56425
  • 51905 - FAD/NAD(P)-binding domain
  • 56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
  • 0Direct
    57756,57756
  • 57756 - Retrovirus zinc finger-like domains
  • 57756 - Retrovirus zinc finger-like domains
  • 0Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    48179,48179
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    53901,53901
  • 53901 - Thiolase-like
  • 53901 - Thiolase-like
  • 0Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    49348,55711
  • 49348 - Clathrin adaptor appendage domain
  • 55711 - Subdomain of clathrin and coatomer appendage domain
  • 0Direct
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    57863,48403
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0Direct
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    56672,100879
  • 56672 - DNA/RNA polymerases
  • 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain
  • 0Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.00000138Direct
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.000002496Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.000002731Direct
    81301,81631
  • 81301 - Nucleotidyltransferase
  • 81631 - PAP/OAS1 substrate-binding domain
  • 0.00009604Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.0004562Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.0009608Direct
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.001284Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.002711Inherited
    101690,53098
  • 101690 - PAZ domain
  • 53098 - Ribonuclease H-like
  • 0.002824Inherited
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0.002824Inherited
    47203,47203
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.002824Inherited
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0.002824Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.004166Inherited
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.004416Inherited
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.006177Inherited
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.006177Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.006971Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.00723Inherited
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0.01005Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.01563Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.01701Inherited
    51735,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0.02546Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.02614Inherited
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.02949Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.02949Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 0.03423Inherited
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0.03723Inherited
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.03723Inherited
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0.03723Inherited
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0.04042Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.04828Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.07282Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.07562Inherited
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.1282Inherited
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0.1282Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.1336Inherited
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.1574Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.2872Inherited
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0.296Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.4615Inherited
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.5184Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.6132Inherited
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0.7521Inherited
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.7895Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9306Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    48452,48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0Direct
    48371,48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    51735,48179,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    55973,55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.0001568Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.0004562Direct
    56645,47203,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.002824Inherited
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.003628Inherited
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.006177Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.006971Inherited
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.02614Inherited
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.03723Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.06414Inherited
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.1172Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.1405Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.2245Inherited
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.6642Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.8044Inherited


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