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Worm Phenotype (WP): organism metabolism processing variant

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Variant [WBPhenotype:0000886] <4>
+ + + 3:   physiology variant [WBPhenotype:0000519] <7>(489|563) (489|241|65)
+ + 2:   organism physiology variant [WBPhenotype:0000576] <10>(357|420) (358|193|57)
+ 1:   organism homeostasis metabolism variant [WBPhenotype:0000577] <17>(347|410) (350|191|56)
0:   organism metabolism processing variant [WBPhenotype:0000027] <25>(171|182) (176|81|24)
- 1:   gene expression variant [WBPhenotype:0000717] <10>(122|134) (129|62|19)
- 1:   lipid metabolism variant [WBPhenotype:0000725] <8>(21|28) (22|8|4)
- 1:   metabolic pathway variant [WBPhenotype:0000463] <8>(35|28) (35|16|8)
- 1:   enzyme activity variant [WBPhenotype:0000727] <5>(6|6) (6|1|0)
- 1:   neurotransmitter metabolism variant [WBPhenotype:0000221] <4>(0|0) (0|0|0)
- 1:   protein interaction variant [WBPhenotype:0001369] <3>(48|48) (48|21|9)
- 1:   ATP levels variant [WBPhenotype:0001574] <2>(2|2) (2|1|0)
- 1:   biogenic amine physiology variant [WBPhenotype:0001518] <2>(0|0) (0|0|0)
- 1:   heme levels variant [WBPhenotype:0002480] <2>(0|0) (0|0|0)
- 1:   energy expenditure variant [WBPhenotype:0001835] <1>(0|0) (0|0|0)
- 1:   glutathione levels variant [WBPhenotype:0001899] <1>(1|1) (1|0|0)
- 1:   neuropeptide metabolism variant [WBPhenotype:0001757] <1>(0|0) (0|0|0)
- 1:   post translational processing variant [WBPhenotype:0000122] <1>(0|0) (0|0|0)
- 1:   GABA levels variant [WBPhenotype:0000552](0|0) (0|0|0)
- 1:   acetylcholine levels variant [WBPhenotype:0000507](0|0) (0|0|0)
- 1:   carbohydrate metabolism variant [WBPhenotype:0002072](0|0) (0|0|0)
- 1:   dietary sugar response variant [WBPhenotype:0002273](0|0) (0|0|0)
- 1:   galactose metabolism variant [WBPhenotype:0002206](0|0) (0|0|0)
- 1:   glucose intolerant [WBPhenotype:0002400](0|0) (0|0|0)
- 1:   glycation variant [WBPhenotype:0002008](0|0) (0|0|0)
- 1:   glycogen levels variant [WBPhenotype:0001892](0|0) (0|0|0)
- 1:   hormone metabolism variant [WBPhenotype:0001843](0|0) (0|0|0)
- 1:   hypersensitive to galactose [WBPhenotype:0002205](0|0) (0|0|0)
- 1:   nonsense mRNA accumulation [WBPhenotype:0000508](2|1) (2|0|0)
- 1:   pheromone production variant [WBPhenotype:0002381](0|0) (0|0|0)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
ValRS/IleRS/LeuRS editing domain0Direct
GroEL-intermediate domain like0Direct
Ribosomal proteins S24e, L23 and L15e0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
SMAD MH1 domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Cu,Zn superoxide dismutase-like0Direct
Tubulin nucleotide-binding domain-like0Direct
Cytochrome c0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
FF domain0Direct
Tubulin C-terminal domain-like0Direct
Cullin homology domain0Direct
JAB1/MPN domain0Direct
F1F0 ATP synthase subunit C0Direct
TK C-terminal domain-like0Direct
Ribosomal protein L10Direct
LEM domain0Direct
L-aspartase-like0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
ISP domain0Direct
GroEL apical domain-like0Direct
Clathrin adaptor appendage domain0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
HSP90 C-terminal domain0Direct
Ribosomal protein L10-like0Direct
Zn-finger domain of Sec23/240Direct
S-adenosylmethionine synthetase0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Nop domain0Direct
Helical domain of Sec23/240Direct
14-3-3 protein0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
LDH C-terminal domain-like0Direct
GroEL equatorial domain-like0Direct
Class II aaRS ABD-related0Direct
Heme-dependent catalase-like0Direct
Oxysterol-binding protein-like0Direct
MIR domain0Direct
RING/U-box0.0000000000004742Direct
ARM repeat0.000000000001464Direct
Histone-fold0.0000000009255Direct
Cysteine proteinases0.000000005812Direct
UBC-like0.00000002299Direct
P-loop containing nucleoside triphosphate hydrolases0.00000002354Direct
"Winged helix" DNA-binding domain0.00000003664Direct
HSP20-like chaperones0.00000007255Direct
WD40 repeat-like0.00000007943Direct
Homeodomain-like0.0000002753Direct
RNA-binding domain, RBD0.00000161Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.000002739Direct
Acyl-CoA dehydrogenase NM domain-like0.000002739Direct
Chaperone J-domain0.000002885Direct
Class II aaRS and biotin synthetases0.00001703Direct
PH domain-like0.00002466Direct
Acid proteases0.00003121Direct
SNARE-like0.00003185Direct
Cysteine-rich domain0.0000648Direct
Actin-like ATPase domain0.000122Direct
Translation proteins SH3-like domain0.000215Direct
Hect, E3 ligase catalytic domain0.0002187Direct
Nucleotidylyl transferase0.0002208Direct
HLH, helix-loop-helix DNA-binding domain0.0002223Direct
Translation proteins0.0002742Direct
beta-beta-alpha zinc fingers0.0002806Direct
Thiolase-like0.0002839Direct
PAP/OAS1 substrate-binding domain0.0003303Direct
Ubiquitin-like0.0004428Direct
Nucleotidyltransferase0.0005447Direct
B-box zinc-binding domain0.0006666Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.0006872Direct
Cullin repeat-like0.0006872Direct
Arginase/deacetylase0.0006872Direct
HMG-box0.001111Inherited
ClpP/crotonase0.001111Inherited
Cyclophilin-like0.001448Inherited
CCCH zinc finger0.001528Inherited
Galactose-binding domain-like0.001584Inherited
PYP-like sensor domain (PAS domain)0.001653Inherited
Sm-like ribonucleoproteins0.003378Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.005774Inherited
Nucleic acid-binding proteins0.006536Inherited
CoA-dependent acyltransferases0.00676Inherited
Riboflavin synthase domain-like0.008168Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.008168Inherited
Calpain large subunit, middle domain (domain III)0.008168Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.008564Inherited
L30e-like0.008564Inherited
ENTH/VHS domain0.008615Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.009312Inherited
Lipovitellin-phosvitin complex, superhelical domain0.009312Inherited
Sec1/munc18-like (SM) proteins0.009312Inherited
beta and beta-prime subunits of DNA dependent RNA-polymerase0.009312Inherited
FKBP-like0.0107Inherited
Ribosomal protein S5 domain 2-like0.01141Inherited
4Fe-4S ferredoxins0.01183Inherited
Frizzled cysteine-rich domain0.01183Inherited
Intermediate filament protein, coiled coil region0.0128Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0128Inherited
SMAD/FHA domain0.01456Inherited
Lipocalins0.01535Inherited
PAZ domain0.01613Inherited
GST C-terminal domain-like0.01744Inherited
Activating enzymes of the ubiquitin-like proteins0.0181Inherited
Seven-hairpin glycosidases0.01921Inherited
Leucine zipper domain0.02033Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.02328Inherited
DHS-like NAD/FAD-binding domain0.02329Inherited
MIT domain0.03108Inherited
ADC-like0.03108Inherited
UBA-like0.03199Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.03437Inherited
Zn-binding ribosomal proteins0.03755Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.03794Inherited
Transducin (alpha subunit), insertion domain0.04054Inherited
Saposin0.04769Inherited
SH3-domain0.04815Inherited
Integrin domains0.05026Inherited
Cdc48 domain 2-like0.05026Inherited
WWE domain0.05026Inherited
Lamin A/C globular tail domain0.05542Inherited
Single hybrid motif0.05542Inherited
Spectrin repeat0.05542Inherited
PX domain0.05542Inherited
p53-like transcription factors0.06125Inherited
SET domain0.07984Inherited
S15/NS1 RNA-binding domain0.09818Inherited
FYVE/PHD zinc finger0.1001Inherited
Acetyl-CoA synthetase-like0.124Inherited
Cyclin-like0.124Inherited
Thioredoxin-like0.1443Inherited
CAD & PB1 domains0.1489Inherited
HSP40/DnaJ peptide-binding domain0.1489Inherited
Tubby C-terminal domain-like0.1489Inherited
ARID-like0.1489Inherited
dsRNA-binding domain-like0.1572Inherited
FAD/NAD(P)-binding domain0.1584Inherited
KA1-like0.1937Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.2021Inherited
Fibronectin type III0.2095Inherited
Quinoprotein alcohol dehydrogenase-like0.2124Inherited
cAMP-binding domain-like0.2347Inherited
Calcium ATPase, transmembrane domain M0.2646Inherited
DNA/RNA polymerases0.2803Inherited
GTPase activation domain, GAP0.3215Inherited
EF-hand0.3704Inherited
Eukaryotic type KH-domain (KH-domain type I)0.3741Inherited
Protein kinase-like (PK-like)0.3761Inherited
SH2 domain0.4295Inherited
Skp1 dimerisation domain-like0.6064Inherited
Second domain of FERM0.6855Inherited
Nuclear receptor ligand-binding domain0.6967Inherited
Periplasmic binding protein-like II0.731Inherited
Snake toxin-like0.8403Inherited
Chromo domain-like0.8741Inherited
Ribonuclease H-like0.8822Inherited
Immunoglobulin0.9266Inherited
Clavaminate synthase-like0.9395Inherited
POZ domain1Inherited
Nucleotide cyclase1Inherited
RNI-like1Inherited
F-box domain1Inherited
Cytochrome P4501Inherited
Voltage-gated potassium channels1Inherited
Periplasmic binding protein-like I1Inherited
PapD-like1Inherited
alpha/beta-Hydrolases1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain0Direct
PDI-like0Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0Direct
ValRS/IleRS/LeuRS editing domain0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Integrin domains0Direct
RNA-polymerase beta0Direct
L30e/L7ae ribosomal proteins0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
Cu,Zn superoxide dismutase-like0Direct
RNA editing terminal uridyl transferase 2, RET2, domain 20Direct
RecA protein-like (ATPase-domain)0Direct
Quinoprotein alcohol dehydrogenase-like0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Clathrin coat assembly domain0Direct
Ribosomal protein L10Direct
Lactate & malate dehydrogenases, C-terminal domain0Direct
MIF4G domain-like0Direct
Cullin repeat0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
ets domain0Direct
Lesion bypass DNA polymerase (Y-family), catalytic domain0Direct
Histone deacetylase, HDAC0Direct
Adenain-like0Direct
Clathrin adaptor core protein0Direct
Acyl-carrier protein (ACP)0Direct
LDH N-terminal domain-like0Direct
CAT-like0Direct
MIR domain0Direct
Nop domain0Direct
HCDH C-domain-like0Direct
S-adenosylmethionine synthetase0Direct
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Anticodon-binding domain of Class II aaRS0Direct
14-3-3 protein0Direct
p120GAP domain-like0Direct
Cullin homology domain0Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
LEM domain0Direct
Group II chaperonin (CCT, TRIC), apical domain0Direct
Tubulin, GTPase domain0Direct
Oxysterol-binding protein0Direct
Erythroid transcription factor GATA-10Direct
Heme-dependent catalases0Direct
SCF ubiquitin ligase complex WHB domain0Direct
DEATH domain, DD0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
POU-specific domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
F1F0 ATP synthase subunit C0Direct
Trunk domain of Sec23/240Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Sir2 family of transcriptional regulators0Direct
Zn-finger domain of Sec23/240Direct
Helical domain of Sec23/240Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
HSP90 C-terminal domain0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
Hsp90 middle domain0Direct
Brix domain0Direct
HSP200Direct
a tRNA synthase domain0Direct
Tubulin, C-terminal domain0Direct
Group II chaperonin (CCT, TRIC), ATPase domain0Direct
beta-sandwich domain of Sec23/240Direct
Proteasome subunits0Direct
SMAD MH1 domain0Direct
Mammalian PLC0Direct
FF domain0Direct
Homeodomain0.0000003798Direct
Actin/HSP700.0000006548Direct
UBC-related0.0000008509Direct
Nucleosome core histones0.000006504Direct
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.000007132Direct
Pepsin-like0.00001618Direct
G proteins0.00003499Direct
Pleckstrin-homology domain (PH domain)0.00005883Direct
Chaperone J-domain0.00006647Direct
Dual specificity phosphatase-like0.00009544Direct
Fatty acid binding protein-like0.0002134Direct
RING finger domain, C3HC40.0003237Direct
Papain-like0.0003301Direct
Tetratricopeptide repeat (TPR)0.0003383Direct
Ubiquitin carboxyl-terminal hydrolase, UCH0.000357Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.0003867Direct
PLC-like (P variant)0.0004505Direct
Hect, E3 ligase catalytic domain0.0007137Direct
Ubiquitin-related0.000735Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.0008092Direct
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.0008745Direct
WD40-repeat0.00118Inherited
Canonical RBD0.001183Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.001281Inherited
HLH, helix-loop-helix DNA-binding domain0.00285Inherited
Armadillo repeat0.002882Inherited
B-box zinc-binding domain0.003467Inherited
SMAD domain0.004173Inherited
Translational machinery components0.004173Inherited
Heat shock protein 70kD (HSP70), peptide-binding domain0.004173Inherited
Thiolase-related0.004173Inherited
HMG-box0.005047Inherited
Cyclophilin (peptidylprolyl isomerase)0.006461Inherited
TBP-associated factors, TAFs0.00687Inherited
acyl-CoA oxidase C-terminal domains0.00865Inherited
acyl-CoA oxidase N-terminal domains0.00865Inherited
CCCH zinc finger0.00964Inherited
Histone lysine methyltransferases0.01387Inherited
Sec1/munc18-like (SM) proteins0.01792Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.01792Inherited
Lipovitellin-phosvitin complex, superhelical domain0.01792Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP0.01814Inherited
Crotonase-like0.01814Inherited
Gastric lipase0.01845Inherited
Calpain large subunit, middle domain (domain III)0.01845Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.02014Inherited
Extended PAW domain0.0212Inherited
Frizzled cysteine-rich domain0.02122Inherited
EF-hand modules in multidomain proteins0.02122Inherited
Transforming growth factor (TGF)-beta0.02122Inherited
LIM domain0.0263Inherited
FKBP immunophilin/proline isomerase0.0263Inherited
Intermediate filament protein, coiled coil region0.03206Inherited
Extended AAA-ATPase domain0.0327Inherited
Ubiquitin activating enzymes (UBA)0.03692Inherited
Class I alpha-1;2-mannosidase, catalytic domain0.03788Inherited
Bacterial lipase0.04866Inherited
Cdc48 N-terminal domain-like0.04866Inherited
MIT domain0.04866Inherited
PDZ domain0.0525Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.05536Inherited
Pumilio repeat0.05536Inherited
Choline/Carnitine O-acyltransferase0.05812Inherited
Elongation factors0.06301Inherited
PAZ domain0.0711Inherited
Leucine zipper domain0.07219Inherited
Anticodon-binding domain0.07538Inherited
Biotin dependent carboxylase carboxyltransferase domain0.07538Inherited
WWE domain0.07538Inherited
Cdc48 domain 2-like0.07538Inherited
Cold shock DNA-binding domain-like0.07872Inherited
6-phosphogluconate dehydrogenase-like, N-terminal domain0.08406Inherited
Lamin A/C globular tail domain0.09338Inherited
Glutathione S-transferase (GST), N-terminal domain0.09669Inherited
PX domain0.1133Inherited
Biotinyl/lipoyl-carrier proteins and domains0.1133Inherited
Transducin (alpha subunit), insertion domain0.1208Inherited
PHD domain0.1557Inherited
Spectrin repeat0.1769Inherited
GABA-aminotransferase-like0.1769Inherited
DEP domain0.2138Inherited
Cyclin0.2226Inherited
SH3-domain0.2407Inherited
Glutathione S-transferase (GST), C-terminal domain0.2455Inherited
I set domains0.301Inherited
Acetyl-CoA synthetase-like0.3064Inherited
First domain of FERM0.3776Inherited
Calmodulin-like0.5376Inherited
Calpain large subunit, catalytic domain (domain II)0.6106Inherited
Synaptotagmin-like (S variant)0.6266Inherited
Third domain of FERM0.6476Inherited
N-acetyl transferase, NAT0.7077Inherited
Phosphate binding protein-like0.7286Inherited
Double-stranded RNA-binding domain (dsRBD)0.7845Inherited
Second domain of FERM0.7881Inherited
SH2 domain0.8017Inherited
Skp1 dimerisation domain-like0.8901Inherited
Nuclear receptor1Inherited
Cytochrome P4501Inherited
Acetylcholinesterase-like1Inherited
F-box domain1Inherited
Protein kinases, catalytic subunit1Inherited
BTB/POZ domain1Inherited
Nuclear receptor ligand-binding domain1Inherited
MSP-like1Inherited
Voltage-gated potassium channels1Inherited
Adenylyl and guanylyl cyclase catalytic domain1Inherited


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Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
GroEL equatorial domain-like0Direct
Oxysterol-binding protein-like0Direct
Clathrin adaptor appendage domain0Direct
Nop domain0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
Heme-dependent catalase-like0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Ribosomal proteins S24e, L23 and L15e0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Class II aaRS ABD-related0Direct
ValRS/IleRS/LeuRS editing domain0Direct
TK C-terminal domain-like0Direct
Helical domain of Sec23/240Direct
L-aspartase-like0Direct
Cullin homology domain0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Ribosomal protein L10Direct
14-3-3 protein0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Ribosomal protein L10-like0Direct
JAB1/MPN domain0Direct
MIR domain0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
SMAD MH1 domain0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
LEM domain0Direct
ISP domain0Direct
Cu,Zn superoxide dismutase-like0Direct
Zn-finger domain of Sec23/240Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
HSP90 C-terminal domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
F1F0 ATP synthase subunit C0Direct
GroEL apical domain-like0Direct
Cytochrome c0Direct
Tubulin nucleotide-binding domain-like0Direct
LDH C-terminal domain-like0Direct
Tubulin C-terminal domain-like0Direct
S-adenosylmethionine synthetase0Direct
GroEL-intermediate domain like0Direct
FF domain0Direct
RING/U-box0.0000000000003755Direct
ARM repeat0.000000000001161Direct
Histone-fold0.0000000007397Direct
Cysteine proteinases0.000000004661Direct
UBC-like0.0000000185Direct
P-loop containing nucleoside triphosphate hydrolases0.00000001894Direct
"Winged helix" DNA-binding domain0.00000002951Direct
HSP20-like chaperones0.0000000585Direct
WD40 repeat-like0.00000006407Direct
Homeodomain-like0.0000002228Direct
RNA-binding domain, RBD0.000001313Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.000002236Direct
Acyl-CoA dehydrogenase NM domain-like0.000002236Direct
Chaperone J-domain0.000002356Direct
Class II aaRS and biotin synthetases0.00001397Direct
PH domain-like0.00002023Direct
Acid proteases0.00002564Direct
SNARE-like0.00002616Direct
Cysteine-rich domain0.00005339Direct
Actin-like ATPase domain0.0001008Direct
Translation proteins SH3-like domain0.0001777Direct
Hect, E3 ligase catalytic domain0.0001808Direct
Nucleotidylyl transferase0.0001826Direct
HLH, helix-loop-helix DNA-binding domain0.0001838Direct
Translation proteins0.0002271Direct
beta-beta-alpha zinc fingers0.0002324Direct
Thiolase-like0.0002352Direct
PAP/OAS1 substrate-binding domain0.0002739Direct
Ubiquitin-like0.0003678Direct
Nucleotidyltransferase0.0004533Direct
B-box zinc-binding domain0.0005563Direct
Arginase/deacetylase0.0005738Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.0005738Direct
Cullin repeat-like0.0005738Direct
HMG-box0.0009313Direct
ClpP/crotonase0.0009313Direct
Cyclophilin-like0.001216Inherited
CCCH zinc finger0.001284Inherited
Galactose-binding domain-like0.001332Inherited
PYP-like sensor domain (PAS domain)0.00139Inherited
Sm-like ribonucleoproteins0.002864Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.004925Inherited
Nucleic acid-binding proteins0.005586Inherited
CoA-dependent acyltransferases0.005779Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.007009Inherited
Riboflavin synthase domain-like0.007009Inherited
Calpain large subunit, middle domain (domain III)0.007009Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.007353Inherited
L30e-like0.007353Inherited
ENTH/VHS domain0.007398Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.008005Inherited
Lipovitellin-phosvitin complex, superhelical domain0.008005Inherited
Sec1/munc18-like (SM) proteins0.008005Inherited
beta and beta-prime subunits of DNA dependent RNA-polymerase0.008005Inherited
FKBP-like0.009217Inherited
Ribosomal protein S5 domain 2-like0.009832Inherited
4Fe-4S ferredoxins0.0102Inherited
Frizzled cysteine-rich domain0.0102Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.01105Inherited
Intermediate filament protein, coiled coil region0.01105Inherited
SMAD/FHA domain0.01258Inherited
Lipocalins0.01328Inherited
PAZ domain0.01396Inherited
GST C-terminal domain-like0.01512Inherited
Activating enzymes of the ubiquitin-like proteins0.0157Inherited
Seven-hairpin glycosidases0.0167Inherited
Leucine zipper domain0.0177Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.02032Inherited
DHS-like NAD/FAD-binding domain0.02033Inherited
ADC-like0.0273Inherited
MIT domain0.0273Inherited
UBA-like0.0281Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.03026Inherited
Zn-binding ribosomal proteins0.03313Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.03348Inherited
Transducin (alpha subunit), insertion domain0.03581Inherited
Saposin0.04227Inherited
SH3-domain0.04269Inherited
Cdc48 domain 2-like0.04458Inherited
WWE domain0.04458Inherited
Integrin domains0.04458Inherited
PX domain0.04924Inherited
Spectrin repeat0.04924Inherited
Single hybrid motif0.04924Inherited
Lamin A/C globular tail domain0.04924Inherited
p53-like transcription factors0.05455Inherited
SET domain0.07166Inherited
S15/NS1 RNA-binding domain0.08858Inherited
FYVE/PHD zinc finger0.09038Inherited
Acetyl-CoA synthetase-like0.1127Inherited
Cyclin-like0.1127Inherited
Thioredoxin-like0.1318Inherited
HSP40/DnaJ peptide-binding domain0.1361Inherited
Tubby C-terminal domain-like0.1361Inherited
CAD & PB1 domains0.1361Inherited
ARID-like0.1361Inherited
dsRNA-binding domain-like0.1439Inherited
FAD/NAD(P)-binding domain0.145Inherited
Thiamin diphosphate-binding fold (THDP-binding)0.1518Inherited
KA1-like0.1782Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.1863Inherited
Fibronectin type III0.1933Inherited
Quinoprotein alcohol dehydrogenase-like0.1961Inherited
cAMP-binding domain-like0.2175Inherited
Calcium ATPase, transmembrane domain M0.2464Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.2507Inherited
DNA/RNA polymerases0.2616Inherited
GTPase activation domain, GAP0.3017Inherited
Insulin-like0.3137Inherited
PDZ domain-like0.332Inherited
Calponin-homology domain, CH-domain0.3367Inherited
EF-hand0.3499Inherited
Eukaryotic type KH-domain (KH-domain type I)0.3537Inherited
Protein kinase-like (PK-like)0.3556Inherited
SH2 domain0.4081Inherited
Skp1 dimerisation domain-like0.5842Inherited
Second domain of FERM0.6645Inherited
Nuclear receptor ligand-binding domain0.676Inherited
Periplasmic binding protein-like II0.7106Inherited
Snake toxin-like0.8225Inherited
Chromo domain-like0.8578Inherited
Ribonuclease H-like0.8661Inherited
Immunoglobulin0.9125Inherited
Clavaminate synthase-like0.9258Inherited
Periplasmic binding protein-like I0.9952Inherited
F-box domain1Inherited
RNI-like1Inherited
Cytochrome P4501Inherited
Nucleotide cyclase1Inherited
POZ domain1Inherited
alpha/beta-Hydrolases1Inherited
PapD-like1Inherited
Voltage-gated potassium channels1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
81383,50978
  • 81383 - F-box domain
  • 50978 - WD40 repeat-like
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    48179,48179
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    57756,57756
  • 57756 - Retrovirus zinc finger-like domains
  • 57756 - Retrovirus zinc finger-like domains
  • 0Direct
    64356,49447
  • 64356 - SNARE-like
  • 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    51905,56425
  • 51905 - FAD/NAD(P)-binding domain
  • 56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    57863,48403
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0Direct
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0Direct
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    56672,100879
  • 56672 - DNA/RNA polymerases
  • 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain
  • 0Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    53901,53901
  • 53901 - Thiolase-like
  • 53901 - Thiolase-like
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    49348,55711
  • 49348 - Clathrin adaptor appendage domain
  • 55711 - Subdomain of clathrin and coatomer appendage domain
  • 0Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    46785,46785
  • 46785 - "Winged helix" DNA-binding domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    52518,52922
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 0Direct
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0Direct
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0Direct
    51735,56327
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 56327 - LDH C-terminal domain-like
  • 0Direct
    81698,81698
  • 81698 - FF domain
  • 81698 - FF domain
  • 0Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.0000007041Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.000002236Direct
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.00000321Direct
    81301,81631
  • 81301 - Nucleotidyltransferase
  • 81631 - PAP/OAS1 substrate-binding domain
  • 0.0001318Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.0005738Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.001257Inherited
    101690,53098
  • 101690 - PAZ domain
  • 53098 - Ribonuclease H-like
  • 0.001382Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.001659Inherited
    47203,47203
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.003356Inherited
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0.003356Inherited
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0.003356Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.00368Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.003776Inherited
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.005443Inherited
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.007353Inherited
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.007353Inherited
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.008005Inherited
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0.008005Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.009082Inherited
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0.01123Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.01396Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.0167Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.01891Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.0273Inherited
    51735,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0.03026Inherited
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.03313Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.03313Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.03581Inherited
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0.0391Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 0.04269Inherited
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0.04351Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.05689Inherited
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.07513Inherited
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0.08858Inherited
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0.131Inherited
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.1361Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.1482Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.1863Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.2971Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.4668Inherited
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.5376Inherited
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.6228Inherited
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0.7614Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9259Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    48452,48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0Direct
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    55973,55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    51735,48179,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    48371,48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.0001808Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.0005738Direct
    56645,47203,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.003356Inherited
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.004069Inherited
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.007353Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.008005Inherited
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.008005Inherited
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.02033Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.1461Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.24Inherited
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.2616Inherited
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.677Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.804Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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