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Worm Phenotype (WP): organism metabolism processing variant

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Variant [WBPhenotype:0000886] <5>
+ + + 3:   physiology variant [WBPhenotype:0000519] <6>(495|573) (496|248|69)
+ + 2:   organism physiology variant [WBPhenotype:0000576] <10>(360|428) (362|200|61)
+ 1:   organism homeostasis metabolism variant [WBPhenotype:0000577] <17>(348|415) (351|198|60)
0:   organism metabolism processing variant [WBPhenotype:0000027] <24>(169|180) (176|83|25)
- 1:   gene expression variant [WBPhenotype:0000717] <10>(119|129) (125|63|20)
- 1:   lipid metabolism variant [WBPhenotype:0000725] <8>(19|24) (20|8|4)
- 1:   metabolic pathway variant [WBPhenotype:0000463] <8>(29|26) (30|12|8)
- 1:   enzyme activity variant [WBPhenotype:0000727] <5>(6|6) (6|1|0)
- 1:   neurotransmitter metabolism variant [WBPhenotype:0000221] <4>(0|0) (0|0|0)
- 1:   protein interaction variant [WBPhenotype:0001369] <3>(47|48) (48|21|9)
- 1:   ATP levels variant [WBPhenotype:0001574] <2>(2|2) (2|1|0)
- 1:   biogenic amine physiology variant [WBPhenotype:0001518] <2>(0|0) (0|0|0)
- 1:   energy expenditure variant [WBPhenotype:0001835] <1>(0|0) (0|0|0)
- 1:   glutathione levels variant [WBPhenotype:0001899] <1>(1|1) (1|0|0)
- 1:   neuropeptide metabolism variant [WBPhenotype:0001757] <1>(0|0) (0|0|0)
- 1:   post translational processing variant [WBPhenotype:0000122] <1>(0|0) (0|0|0)
- 1:   GABA levels variant [WBPhenotype:0000552](0|0) (0|0|0)
- 1:   acetylcholine levels variant [WBPhenotype:0000507](0|0) (0|0|0)
- 1:   carbohydrate metabolism variant [WBPhenotype:0002072](0|0) (0|0|0)
- 1:   dietary sugar response variant [WBPhenotype:0002273](0|0) (0|0|0)
- 1:   galactose metabolism variant [WBPhenotype:0002206](0|0) (0|0|0)
- 1:   glucose intolerant [WBPhenotype:0002400](0|0) (0|0|0)
- 1:   glycation variant [WBPhenotype:0002008](0|0) (0|0|0)
- 1:   glycogen levels variant [WBPhenotype:0001892](0|0) (0|0|0)
- 1:   hormone metabolism variant [WBPhenotype:0001843](0|0) (0|0|0)
- 1:   hypersensitive to galactose [WBPhenotype:0002205](0|0) (0|0|0)
- 1:   nonsense mRNA accumulation [WBPhenotype:0000508](2|1) (2|0|0)
- 1:   pheromone production variant [WBPhenotype:0002381](0|0) (0|0|0)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
GroEL apical domain-like0Direct
LEM domain0Direct
Ribosomal protein L10-like0Direct
GroEL equatorial domain-like0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Heme-dependent catalase-like0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
LDH C-terminal domain-like0Direct
Tubulin C-terminal domain-like0Direct
Nop domain0Direct
Clathrin adaptor appendage domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Subdomain of clathrin and coatomer appendage domain0Direct
Cullin homology domain0Direct
TK C-terminal domain-like0Direct
SMAD MH1 domain0Direct
JAB1/MPN domain0Direct
Restriction endonuclease-like0Direct
S-adenosylmethionine synthetase0Direct
MIR domain0Direct
Cu,Zn superoxide dismutase-like0Direct
HSP90 C-terminal domain0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
F1F0 ATP synthase subunit C0Direct
Ribosomal protein L10Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Oxysterol-binding protein-like0Direct
FF domain0Direct
L-aspartase-like0Direct
Tubulin nucleotide-binding domain-like0Direct
GroEL-intermediate domain like0Direct
ISP domain0Direct
Class II aaRS ABD-related0Direct
Helical domain of Sec23/240Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Ribosomal proteins S24e, L23 and L15e0Direct
Zn-finger domain of Sec23/240Direct
14-3-3 protein0Direct
RING/U-box0.000000000000001776Direct
ARM repeat0.000000000001429Direct
Cysteine proteinases0.0000000003237Direct
WD40 repeat-like0.00000000164Direct
Histone-fold0.0000000184Direct
"Winged helix" DNA-binding domain0.00000004704Direct
P-loop containing nucleoside triphosphate hydrolases0.0000000695Direct
UBC-like0.0000001294Direct
Homeodomain-like0.0000002349Direct
HSP20-like chaperones0.0000007572Direct
RNA-binding domain, RBD0.000001572Direct
Chaperone J-domain0.000001675Direct
Acyl-CoA dehydrogenase NM domain-like0.000001768Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.000001768Direct
PH domain-like0.000003971Direct
Class II aaRS and biotin synthetases0.00002167Direct
SNARE-like0.00002701Direct
beta-beta-alpha zinc fingers0.00005531Direct
Nucleotidylyl transferase0.00008469Direct
Thiolase-like0.0000907Direct
HLH, helix-loop-helix DNA-binding domain0.0001411Direct
Translation proteins SH3-like domain0.0001874Direct
Translation proteins0.0001904Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0002266Direct
PAP/OAS1 substrate-binding domain0.0002469Direct
Actin-like ATPase domain0.0002905Direct
Ubiquitin-like0.0003158Direct
Acid proteases0.0003465Direct
Nucleotidyltransferase0.000404Direct
Cysteine-rich domain0.0004152Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.0005627Direct
Cullin repeat-like0.0005627Direct
Arginase/deacetylase0.0005627Direct
Hect, E3 ligase catalytic domain0.0005627Direct
B-box zinc-binding domain0.0005709Direct
CCCH zinc finger0.0011Inherited
Cyclophilin-like0.001263Inherited
PYP-like sensor domain (PAS domain)0.001393Inherited
Sm-like ribonucleoproteins0.002956Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.004312Inherited
HMG-box0.004509Inherited
ClpP/crotonase0.004509Inherited
CoA-dependent acyltransferases0.006047Inherited
Nucleic acid-binding proteins0.006306Inherited
ENTH/VHS domain0.007103Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.007349Inherited
DEATH domain0.007349Inherited
Riboflavin synthase domain-like0.007602Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.007602Inherited
Calpain large subunit, middle domain (domain III)0.007602Inherited
beta and beta-prime subunits of DNA dependent RNA-polymerase0.008259Inherited
Sec1/munc18-like (SM) proteins0.008259Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.009178Inherited
FKBP-like0.009889Inherited
Intermediate filament protein, coiled coil region0.01089Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.01089Inherited
Frizzled cysteine-rich domain0.01122Inherited
Lipocalins0.01211Inherited
Galactose-binding domain-like0.01229Inherited
PAZ domain0.01419Inherited
GST C-terminal domain-like0.01421Inherited
Activating enzymes of the ubiquitin-like proteins0.01596Inherited
Saposin0.01689Inherited
Seven-hairpin glycosidases0.01823Inherited
Leucine zipper domain0.01829Inherited
DHS-like NAD/FAD-binding domain0.02193Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.02953Inherited
MIT domain0.03008Inherited
ADC-like0.03008Inherited
Ribosomal protein S5 domain 2-like0.03193Inherited
Zn-binding ribosomal proteins0.034Inherited
SH3-domain0.03573Inherited
L30e-like0.04343Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.04655Inherited
Integrin domains0.04706Inherited
WWE domain0.04706Inherited
Cdc48 domain 2-like0.04706Inherited
Spectrin repeat0.04923Inherited
Lamin A/C globular tail domain0.04923Inherited
Single hybrid motif0.04923Inherited
p53-like transcription factors0.05595Inherited
FYVE/PHD zinc finger0.05827Inherited
UBA-like0.07016Inherited
Ferritin-like0.07075Inherited
SET domain0.07269Inherited
Acetyl-CoA synthetase-like0.0728Inherited
Transducin (alpha subunit), insertion domain0.08251Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.08546Inherited
S15/NS1 RNA-binding domain0.0961Inherited
Cyclin-like0.1065Inherited
Calcium ATPase, transmembrane domain M0.1244Inherited
Growth factor receptor domain0.1302Inherited
FAD/NAD(P)-binding domain0.1311Inherited
CAD & PB1 domains0.1417Inherited
Tubby C-terminal domain-like0.1417Inherited
ARID-like0.1417Inherited
HSP40/DnaJ peptide-binding domain0.1417Inherited
t-snare proteins0.1545Inherited
Thiamin diphosphate-binding fold (THDP-binding)0.1545Inherited
Thioredoxin-like0.1588Inherited
EF-hand0.1857Inherited
GTPase activation domain, GAP0.1885Inherited
KA1-like0.1911Inherited
Quinoprotein alcohol dehydrogenase-like0.1934Inherited
Fibronectin type III0.1951Inherited
Calponin-homology domain, CH-domain0.1984Inherited
dsRNA-binding domain-like0.205Inherited
cAMP-binding domain-like0.2175Inherited
Eukaryotic type KH-domain (KH-domain type I)0.2311Inherited
DNA/RNA polymerases0.2738Inherited
Nuclear receptor ligand-binding domain0.5792Inherited
SH2 domain0.6029Inherited
Protein kinase-like (PK-like)0.622Inherited
Second domain of FERM0.6698Inherited
Periplasmic binding protein-like II0.719Inherited
Skp1 dimerisation domain-like0.7655Inherited
Chromo domain-like0.8633Inherited
Immunoglobulin0.9244Inherited
Ribonuclease H-like0.9367Inherited
POZ domain1Inherited
Periplasmic binding protein-like I1Inherited
Nucleotide cyclase1Inherited
Neurotransmitter-gated ion-channel transmembrane pore1Inherited
RNI-like1Inherited
alpha/beta-Hydrolases1Inherited
F-box domain1Inherited
Voltage-gated potassium channels1Inherited
PapD-like1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Hsp90 middle domain0Direct
Clathrin adaptor core protein0Direct
XPF/Rad1/Mus81 nuclease0Direct
Ribosomal protein L10Direct
LEM domain0Direct
RNA-polymerase beta0Direct
Lesion bypass DNA polymerase (Y-family), catalytic domain0Direct
Erythroid transcription factor GATA-10Direct
Mammalian PLC0Direct
ets domain0Direct
DEATH domain, DD0Direct
F1F0 ATP synthase subunit C0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Lactate & malate dehydrogenases, C-terminal domain0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain0Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Histone deacetylase, HDAC0Direct
beta-sandwich domain of Sec23/240Direct
a tRNA synthase domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Sir2 family of transcriptional regulators0Direct
POU-specific domain0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Group II chaperonin (CCT, TRIC), apical domain0Direct
FF domain0Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
Anticodon-binding domain of Class II aaRS0Direct
HSP90 C-terminal domain0Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
CAT-like0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Acyl-carrier protein (ACP)0Direct
MIR domain0Direct
Zn-finger domain of Sec23/240Direct
Cu,Zn superoxide dismutase-like0Direct
Heme-dependent catalases0Direct
Tubulin, C-terminal domain0Direct
Tubulin, GTPase domain0Direct
SMAD MH1 domain0Direct
Quinoprotein alcohol dehydrogenase-like0Direct
S-adenosylmethionine synthetase0Direct
Oxysterol-binding protein0Direct
Ribonucleotide reductase-like0Direct
LDH N-terminal domain-like0Direct
14-3-3 protein0Direct
HCDH C-domain-like0Direct
L30e/L7ae ribosomal proteins0Direct
Group II chaperonin (CCT, TRIC), ATPase domain0Direct
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta0Direct
Trunk domain of Sec23/240Direct
RecA protein-like (ATPase-domain)0Direct
Nop domain0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Helical domain of Sec23/240Direct
Adenain-like0Direct
Brix domain0Direct
RNA editing terminal uridyl transferase 2, RET2, domain 20Direct
Proteasome subunits0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
Integrin domains0Direct
Cullin homology domain0Direct
PDI-like0Direct
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain0Direct
Clathrin coat assembly domain0Direct
MIF4G domain-like0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
SCF ubiquitin ligase complex WHB domain0Direct
p120GAP domain-like0Direct
Cullin repeat0Direct
Homeodomain0.0000005114Direct
UBC-related0.0000006376Direct
Nucleosome core histones0.000000851Direct
Actin/HSP700.000005643Direct
Pepsin-like0.000005772Direct
RING finger domain, C3HC40.00001931Direct
G proteins0.00002006Direct
Ubiquitin carboxyl-terminal hydrolase, UCH0.00002431Direct
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.00003354Direct
Pleckstrin-homology domain (PH domain)0.00003557Direct
Chaperone J-domain0.00004132Direct
Dual specificity phosphatase-like0.0001542Direct
Fatty acid binding protein-like0.0001662Direct
Papain-like0.0002644Direct
WD40-repeat0.0002777Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.0003303Direct
PLC-like (P variant)0.0003588Direct
Ubiquitin-related0.0005937Direct
Canonical RBD0.0006068Direct
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.0006604Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.000699Direct
Tetratricopeptide repeat (TPR)0.0007499Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0007724Direct
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.001076Inherited
Thiolase-related0.001659Inherited
Hect, E3 ligase catalytic domain0.001659Inherited
HLH, helix-loop-helix DNA-binding domain0.001955Inherited
Armadillo repeat0.002348Inherited
B-box zinc-binding domain0.003013Inherited
Heat shock protein 70kD (HSP70), peptide-binding domain0.003561Inherited
Translational machinery components0.003561Inherited
SMAD domain0.003561Inherited
HSP200.003561Inherited
Cyclophilin (peptidylprolyl isomerase)0.0057Inherited
CCCH zinc finger0.00732Inherited
acyl-CoA oxidase C-terminal domains0.007574Inherited
acyl-CoA oxidase N-terminal domains0.007574Inherited
Histone lysine methyltransferases0.01239Inherited
Sec1/munc18-like (SM) proteins0.01607Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP0.01618Inherited
Calpain large subunit, middle domain (domain III)0.01726Inherited
Gastric lipase0.01726Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.01753Inherited
Frizzled cysteine-rich domain0.02023Inherited
Transforming growth factor (TGF)-beta0.02023Inherited
EF-hand modules in multidomain proteins0.02023Inherited
LIM domain0.02451Inherited
FKBP immunophilin/proline isomerase0.02451Inherited
Extended AAA-ATPase domain0.02464Inherited
Intermediate filament protein, coiled coil region0.02783Inherited
Ubiquitin activating enzymes (UBA)0.03395Inherited
Class I alpha-1;2-mannosidase, catalytic domain0.03606Inherited
Crotonase-like0.03749Inherited
Glutathione S-transferase (GST), N-terminal domain0.04566Inherited
Bacterial lipase0.04712Inherited
Cdc48 N-terminal domain-like0.04712Inherited
MIT domain0.04712Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.04916Inherited
Elongation factors0.05391Inherited
Extended PAW domain0.05391Inherited
Pumilio repeat0.05465Inherited
Choline/Carnitine O-acyltransferase0.05465Inherited
PDZ domain0.0629Inherited
PAZ domain0.06433Inherited
Leucine zipper domain0.066Inherited
Cold shock DNA-binding domain-like0.06693Inherited
WWE domain0.07092Inherited
Anticodon-binding domain0.07092Inherited
Cdc48 domain 2-like0.07092Inherited
6-phosphogluconate dehydrogenase-like, N-terminal domain0.07413Inherited
Lamin A/C globular tail domain0.08515Inherited
Biotinyl/lipoyl-carrier proteins and domains0.1027Inherited
Glutathione S-transferase (GST), C-terminal domain0.1496Inherited
Spectrin repeat0.1638Inherited
GABA-aminotransferase-like0.1654Inherited
SH3-domain0.1992Inherited
Cyclin0.2018Inherited
DEP domain0.2045Inherited
Transducin (alpha subunit), insertion domain0.2087Inherited
Acetyl-CoA synthetase-like0.2129Inherited
t-snare proteins0.2527Inherited
cAMP-binding domain0.2698Inherited
PHD domain0.2774Inherited
I set domains0.2897Inherited
First domain of FERM0.3669Inherited
Calmodulin-like0.379Inherited
Calponin-homology domain, CH-domain0.4233Inherited
Fibronectin type III0.4885Inherited
Calpain large subunit, catalytic domain (domain II)0.5938Inherited
Synaptotagmin-like (S variant)0.6256Inherited
Third domain of FERM0.6379Inherited
N-acetyl transferase, NAT0.7076Inherited
Phosphate binding protein-like0.7178Inherited
Second domain of FERM0.779Inherited
Double-stranded RNA-binding domain (dsRBD)0.8721Inherited
SH2 domain0.9404Inherited
Nuclear receptor ligand-binding domain0.9799Inherited
Skp1 dimerisation domain-like0.9919Inherited
MSP-like1Inherited
Protein kinases, catalytic subunit1Inherited
BTB/POZ domain1Inherited
Acetylcholinesterase-like1Inherited
Adenylyl and guanylyl cyclase catalytic domain1Inherited
F-box domain1Inherited
Voltage-gated potassium channels1Inherited
Nuclear receptor1Inherited


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Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
MIR domain0Direct
Clathrin adaptor appendage domain0Direct
S-adenosylmethionine synthetase0Direct
Oxysterol-binding protein-like0Direct
14-3-3 protein0Direct
SMAD MH1 domain0Direct
Cu,Zn superoxide dismutase-like0Direct
Tubulin nucleotide-binding domain-like0Direct
Zn-finger domain of Sec23/240Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
HSP90 C-terminal domain0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
GroEL apical domain-like0Direct
Ribosomal protein L10-like0Direct
Heme-dependent catalase-like0Direct
TK C-terminal domain-like0Direct
ValRS/IleRS/LeuRS editing domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Restriction endonuclease-like0Direct
Ribosomal protein L10Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
ISP domain0Direct
L-aspartase-like0Direct
Class II aaRS ABD-related0Direct
LDH C-terminal domain-like0Direct
JAB1/MPN domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Cullin homology domain0Direct
F1F0 ATP synthase subunit C0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Ribosomal proteins S24e, L23 and L15e0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Nop domain0Direct
LEM domain0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
FF domain0Direct
GroEL equatorial domain-like0Direct
Tubulin C-terminal domain-like0Direct
Helical domain of Sec23/240Direct
GroEL-intermediate domain like0Direct
RING/U-box0.000000000000001386Direct
ARM repeat0.000000000001122Direct
Cysteine proteinases0.0000000002558Direct
WD40 repeat-like0.0000000013Direct
Histone-fold0.00000001463Direct
"Winged helix" DNA-binding domain0.00000003751Direct
P-loop containing nucleoside triphosphate hydrolases0.00000005547Direct
UBC-like0.0000001034Direct
Homeodomain-like0.0000001882Direct
HSP20-like chaperones0.0000006093Direct
RNA-binding domain, RBD0.000001268Direct
Chaperone J-domain0.000001352Direct
Acyl-CoA dehydrogenase NM domain-like0.000001427Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.000001427Direct
PH domain-like0.00000321Direct
Class II aaRS and biotin synthetases0.00001759Direct
SNARE-like0.00002194Direct
beta-beta-alpha zinc fingers0.00004504Direct
Nucleotidylyl transferase0.00006908Direct
Thiolase-like0.000074Direct
HLH, helix-loop-helix DNA-binding domain0.0001153Direct
Translation proteins SH3-like domain0.0001532Direct
Translation proteins0.0001556Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0001853Direct
PAP/OAS1 substrate-binding domain0.0002022Direct
Actin-like ATPase domain0.0002382Direct
Ubiquitin-like0.0002591Direct
Acid proteases0.0002845Direct
Nucleotidyltransferase0.0003322Direct
Cysteine-rich domain0.0003414Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.0004637Direct
Hect, E3 ligase catalytic domain0.0004637Direct
Arginase/deacetylase0.0004637Direct
Cullin repeat-like0.0004637Direct
B-box zinc-binding domain0.0004705Direct
CCCH zinc finger0.0009121Direct
Cyclophilin-like0.001049Inherited
PYP-like sensor domain (PAS domain)0.001158Inherited
Sm-like ribonucleoproteins0.002485Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.003642Inherited
HMG-box0.003811Inherited
ClpP/crotonase0.003811Inherited
CoA-dependent acyltransferases0.005131Inherited
Nucleic acid-binding proteins0.005353Inherited
ENTH/VHS domain0.00604Inherited
DEATH domain0.006252Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.006252Inherited
Riboflavin synthase domain-like0.006472Inherited
Calpain large subunit, middle domain (domain III)0.006472Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.006472Inherited
beta and beta-prime subunits of DNA dependent RNA-polymerase0.00704Inherited
Sec1/munc18-like (SM) proteins0.00704Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.007838Inherited
FKBP-like0.008454Inherited
Intermediate filament protein, coiled coil region0.009328Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.009328Inherited
Frizzled cysteine-rich domain0.00962Inherited
Lipocalins0.01039Inherited
Galactose-binding domain-like0.01055Inherited
PAZ domain0.01221Inherited
GST C-terminal domain-like0.01223Inherited
Activating enzymes of the ubiquitin-like proteins0.01377Inherited
Saposin0.01459Inherited
Seven-hairpin glycosidases0.01577Inherited
Leucine zipper domain0.01583Inherited
DHS-like NAD/FAD-binding domain0.01905Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.0258Inherited
ADC-like0.02629Inherited
MIT domain0.02629Inherited
Ribosomal protein S5 domain 2-like0.02791Inherited
Zn-binding ribosomal proteins0.02976Inherited
SH3-domain0.03131Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.03749Inherited
Lipovitellin-phosvitin complex, superhelical domain0.03749Inherited
L30e-like0.0382Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.04101Inherited
Cdc48 domain 2-like0.04148Inherited
Integrin domains0.04148Inherited
WWE domain0.04148Inherited
Lamin A/C globular tail domain0.04344Inherited
Single hybrid motif0.04344Inherited
Spectrin repeat0.04344Inherited
DBL homology domain (DH-domain)0.04889Inherited
p53-like transcription factors0.04954Inherited
FYVE/PHD zinc finger0.05165Inherited
UBA-like0.06244Inherited
Translational machinery components0.06298Inherited
Ferritin-like0.06298Inherited
SET domain0.06475Inherited
Acetyl-CoA synthetase-like0.06486Inherited
Transducin (alpha subunit), insertion domain0.07377Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.07649Inherited
S15/NS1 RNA-binding domain0.08633Inherited
Cyclin-like0.09601Inherited
Calcium ATPase, transmembrane domain M0.1126Inherited
Growth factor receptor domain0.118Inherited
FAD/NAD(P)-binding domain0.1189Inherited
CAD & PB1 domains0.1289Inherited
Tubby C-terminal domain-like0.1289Inherited
ARID-like0.1289Inherited
HSP40/DnaJ peptide-binding domain0.1289Inherited
t-snare proteins0.1409Inherited
Thiamin diphosphate-binding fold (THDP-binding)0.1409Inherited
Thioredoxin-like0.145Inherited
EF-hand0.1701Inherited
GTPase activation domain, GAP0.1728Inherited
KA1-like0.1754Inherited
Osmotin, thaumatin-like protein0.1754Inherited
Quinoprotein alcohol dehydrogenase-like0.1775Inherited
Fibronectin type III0.1792Inherited
Calponin-homology domain, CH-domain0.1824Inherited
dsRNA-binding domain-like0.1886Inherited
cAMP-binding domain-like0.2007Inherited
Eukaryotic type KH-domain (KH-domain type I)0.2137Inherited
DNA/RNA polymerases0.2547Inherited
Insulin-like0.3023Inherited
PDZ domain-like0.4072Inherited
Nuclear receptor ligand-binding domain0.5569Inherited
SH2 domain0.5808Inherited
Protein kinase-like (PK-like)0.6001Inherited
Second domain of FERM0.6486Inherited
Periplasmic binding protein-like II0.6989Inherited
Skp1 dimerisation domain-like0.7468Inherited
Chromo domain-like0.8484Inherited
Immunoglobulin0.9121Inherited
Ribonuclease H-like0.9247Inherited
Periplasmic binding protein-like I0.9994Inherited
Neurotransmitter-gated ion-channel transmembrane pore1Inherited
RNI-like1Inherited
Voltage-gated potassium channels1Inherited
POZ domain1Inherited
alpha/beta-Hydrolases1Inherited
F-box domain1Inherited
PapD-like1Inherited
Nucleotide cyclase1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    46785,46785
  • 46785 - "Winged helix" DNA-binding domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    64356,49447
  • 64356 - SNARE-like
  • 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor
  • 0Direct
    56672,100879
  • 56672 - DNA/RNA polymerases
  • 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain
  • 0Direct
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    53901,53901
  • 53901 - Thiolase-like
  • 53901 - Thiolase-like
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    51735,56327
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 56327 - LDH C-terminal domain-like
  • 0Direct
    48179,48179
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0Direct
    55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    81698,81698
  • 81698 - FF domain
  • 81698 - FF domain
  • 0Direct
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0Direct
    51905,56425
  • 51905 - FAD/NAD(P)-binding domain
  • 56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    52518,52922
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    49348,55711
  • 49348 - Clathrin adaptor appendage domain
  • 55711 - Subdomain of clathrin and coatomer appendage domain
  • 0Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    57756,57756
  • 57756 - Retrovirus zinc finger-like domains
  • 57756 - Retrovirus zinc finger-like domains
  • 0Direct
    57863,48403
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0Direct
    81383,50978
  • 81383 - F-box domain
  • 50978 - WD40 repeat-like
  • 0Direct
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.000001427Direct
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.000002565Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.00000284Direct
    81301,81631
  • 81301 - Nucleotidyltransferase
  • 81631 - PAP/OAS1 substrate-binding domain
  • 0.00009818Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.0004637Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.0009792Direct
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.001312Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.002772Inherited
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0.002859Inherited
    47203,47203
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.002859Inherited
    101690,53098
  • 101690 - PAZ domain
  • 53098 - Ribonuclease H-like
  • 0.002859Inherited
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0.002859Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.004256Inherited
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.004484Inherited
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.006252Inherited
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.006252Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.00704Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.007345Inherited
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0.01019Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.01577Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.01714Inherited
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.02073Inherited
    51735,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0.0258Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.02629Inherited
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.02976Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.02976Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 0.03505Inherited
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0.03749Inherited
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.03749Inherited
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0.03749Inherited
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0.04083Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.04889Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.07377Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.07649Inherited
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0.1289Inherited
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.1289Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.1347Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.2887Inherited
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0.2977Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.4633Inherited
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.5204Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.6188Inherited
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0.754Inherited
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.7922Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9327Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    55973,55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    48452,48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    51735,48179,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    48371,48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.0001591Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.0004637Direct
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.002599Inherited
    56645,47203,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.002859Inherited
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.00368Inherited
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.006252Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.00704Inherited
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.03749Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.06477Inherited
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.1185Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.1415Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.2257Inherited
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.6661Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.8064Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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