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Worm Phenotype (WP): organism metabolism processing variant

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Variant [WBPhenotype:0000886] <2>
+ + + 3:   physiology variant [WBPhenotype:0000519] <14>(510|587) (510|248|69)
+ + 2:   organism physiology variant [WBPhenotype:0000576] <9>(369|431) (372|193|57)
+ 1:   organism homeostasis metabolism variant [WBPhenotype:0000577] <16>(361|421) (363|190|56)
0:   organism metabolism processing variant [WBPhenotype:0000027] <25>(178|190) (182|87|26)
- 1:   gene expression variant [WBPhenotype:0000717] <11>(127|139) (131|64|20)
- 1:   lipid metabolism variant [WBPhenotype:0000725] <8>(19|27) (22|8|4)
- 1:   metabolic pathway variant [WBPhenotype:0000463] <8>(39|32) (39|15|9)
- 1:   diet response variant [WBPhenotype:0002525] <5>(0|0) (0|0|0)
- 1:   enzyme activity variant [WBPhenotype:0000727] <5>(6|6) (6|1|0)
- 1:   neurotransmitter metabolism variant [WBPhenotype:0000221] <4>(0|0) (0|0|0)
- 1:   protein interaction variant [WBPhenotype:0001369] <4>(47|49) (48|21|9)
- 1:   ATP levels variant [WBPhenotype:0001574] <2>(2|2) (2|1|0)
- 1:   biogenic amine physiology variant [WBPhenotype:0001518] <2>(0|0) (0|0|0)
- 1:   heme levels variant [WBPhenotype:0002480] <2>(0|0) (0|0|0)
- 1:   energy expenditure variant [WBPhenotype:0001835] <1>(0|0) (0|0|0)
- 1:   glutathione levels variant [WBPhenotype:0001899] <1>(1|1) (1|0|0)
- 1:   neuropeptide metabolism variant [WBPhenotype:0001757] <1>(0|0) (0|0|0)
- 1:   post translational processing variant [WBPhenotype:0000122] <1>(0|0) (0|0|0)
- 1:   GABA levels variant [WBPhenotype:0000552](0|0) (0|0|0)
- 1:   acetylcholine levels variant [WBPhenotype:0000507](0|0) (0|0|0)
- 1:   carbohydrate metabolism variant [WBPhenotype:0002072](0|0) (0|0|0)
- 1:   galactose metabolism variant [WBPhenotype:0002206](0|0) (0|0|0)
- 1:   glucose intolerant [WBPhenotype:0002400](0|0) (0|0|0)
- 1:   glycation variant [WBPhenotype:0002008](0|0) (0|0|0)
- 1:   glycogen levels variant [WBPhenotype:0001892](0|0) (0|0|0)
- 1:   hormone metabolism variant [WBPhenotype:0001843](0|0) (0|0|0)
- 1:   hypersensitive to galactose [WBPhenotype:0002205](0|0) (0|0|0)
- 1:   nonsense mRNA accumulation [WBPhenotype:0000508](2|1) (2|0|0)
- 1:   pheromone production variant [WBPhenotype:0002381](0|0) (0|0|0)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
SMAD MH1 domain0Direct
Helical domain of Sec23/240Direct
LDH C-terminal domain-like0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
JAB1/MPN domain0Direct
S-adenosylmethionine synthetase0Direct
LEM domain0Direct
L-aspartase-like0Direct
Cu,Zn superoxide dismutase-like0Direct
ISP domain0Direct
Tubulin C-terminal domain-like0Direct
MIR domain0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Ribosomal protein L10Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
Heme-dependent catalase-like0Direct
PEP carboxykinase N-terminal domain0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Ribosomal proteins S24e, L23 and L15e0Direct
Tubulin nucleotide-binding domain-like0Direct
Class II aaRS ABD-related0Direct
Cytochrome c0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
TK C-terminal domain-like0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
GroEL apical domain-like0Direct
Nop domain0Direct
Sec1/munc18-like (SM) proteins0Direct
FF domain0Direct
Cullin homology domain0Direct
Thiolase-like0Direct
Oxysterol-binding protein-like0Direct
PEP carboxykinase-like0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Zn-finger domain of Sec23/240Direct
F1F0 ATP synthase subunit C0Direct
HSP90 C-terminal domain0Direct
GroEL equatorial domain-like0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
Putative DNA-binding domain0Direct
Clathrin adaptor appendage domain0Direct
14-3-3 protein0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
GroEL-intermediate domain like0Direct
Ribosomal protein L10-like0Direct
Histone-fold0.000000000000264Direct
RING/U-box0.000000000000447Direct
ARM repeat0.000000000002866Direct
"Winged helix" DNA-binding domain0.000000000002999Direct
Cysteine proteinases0.00000003168Direct
P-loop containing nucleoside triphosphate hydrolases0.00000005089Direct
UBC-like0.0000000687Direct
Chromo domain-like0.00000006979Direct
HSP20-like chaperones0.0000001623Direct
Homeodomain-like0.0000002466Direct
RNA-binding domain, RBD0.0000004221Direct
WD40 repeat-like0.0000005886Direct
FYVE/PHD zinc finger0.000001963Direct
SET domain0.000003079Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.000005515Direct
Acyl-CoA dehydrogenase NM domain-like0.000005515Direct
Chaperone J-domain0.000006852Direct
Class II aaRS and biotin synthetases0.00003245Direct
SNARE-like0.00005353Direct
Acid proteases0.00005603Direct
PH domain-like0.0001054Direct
Cysteine-rich domain0.0001335Direct
Bromodomain0.0002522Direct
Actin-like ATPase domain0.0002605Direct
Hect, E3 ligase catalytic domain0.0003163Direct
Translation proteins SH3-like domain0.0003305Direct
CoA-dependent acyltransferases0.0003831Direct
Nucleotidylyl transferase0.0004152Direct
HLH, helix-loop-helix DNA-binding domain0.0004558Direct
Translation proteins0.0004886Direct
PAP/OAS1 substrate-binding domain0.0005254Direct
beta-beta-alpha zinc fingers0.0006716Direct
Nucleotidyltransferase0.0008787Direct
Cullin repeat-like0.0009551Direct
Arginase/deacetylase0.0009551Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.0009551Direct
B-box zinc-binding domain0.001089Inherited
Ubiquitin-like0.001236Inherited
HMG-box0.001729Inherited
ClpP/crotonase0.001729Inherited
Activating enzymes of the ubiquitin-like proteins0.002208Inherited
PYP-like sensor domain (PAS domain)0.002208Inherited
Cyclophilin-like0.002262Inherited
CCCH zinc finger0.002594Inherited
Nucleic acid-binding proteins0.002665Inherited
Galactose-binding domain-like0.003013Inherited
ACP-like0.005073Inherited
Sm-like ribonucleoproteins0.005137Inherited
Retrovirus zinc finger-like domains0.006383Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.009354Inherited
Calpain large subunit, middle domain (domain III)0.0106Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.0106Inherited
Riboflavin synthase domain-like0.0106Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.01115Inherited
L30e-like0.01115Inherited
beta and beta-prime subunits of DNA dependent RNA-polymerase0.01153Inherited
Translational machinery components0.01153Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.01153Inherited
Lipovitellin-phosvitin complex, superhelical domain0.01153Inherited
Tudor/PWWP/MBT0.01195Inherited
FKBP-like0.01416Inherited
4Fe-4S ferredoxins0.01443Inherited
Frizzled cysteine-rich domain0.01443Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.01687Inherited
Intermediate filament protein, coiled coil region0.01687Inherited
UBA-like0.01761Inherited
SMAD/FHA domain0.0213Inherited
Lipocalins0.02278Inherited
Seven-hairpin glycosidases0.024Inherited
PAZ domain0.02499Inherited
DHS-like NAD/FAD-binding domain0.02969Inherited
Leucine zipper domain0.02981Inherited
GST C-terminal domain-like0.03354Inherited
MIT domain0.03648Inherited
ADC-like0.03648Inherited
dsRNA-binding domain-like0.04511Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.04511Inherited
Zn-binding ribosomal proteins0.04565Inherited
Transducin (alpha subunit), insertion domain0.05626Inherited
Cyclin-like0.05771Inherited
Acetyl-CoA synthetase-like0.05787Inherited
WWE domain0.058Inherited
Cdc48 domain 2-like0.058Inherited
Integrin domains0.058Inherited
HIT/MYND zinc finger-like0.06083Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.06197Inherited
Saposin0.06712Inherited
Lamin A/C globular tail domain0.06926Inherited
Spectrin repeat0.06926Inherited
Single hybrid motif0.06926Inherited
PX domain0.06926Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.07909Inherited
p53-like transcription factors0.08592Inherited
SH3-domain0.09819Inherited
FAD/NAD(P)-binding domain0.1013Inherited
DNA/RNA polymerases0.1044Inherited
S15/NS1 RNA-binding domain0.1129Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.1268Inherited
Thioredoxin-like0.1587Inherited
Tubby C-terminal domain-like0.1682Inherited
CAD & PB1 domains0.1682Inherited
HSP40/DnaJ peptide-binding domain0.1682Inherited
ARID-like0.1682Inherited
Calcium ATPase, transmembrane domain M0.178Inherited
KA1-like0.2188Inherited
EF-hand0.221Inherited
Quinoprotein alcohol dehydrogenase-like0.2557Inherited
SAM/Pointed domain0.3051Inherited
Eukaryotic type KH-domain (KH-domain type I)0.3052Inherited
GTPase activation domain, GAP0.3899Inherited
Protein kinase-like (PK-like)0.4582Inherited
PDZ domain-like0.4949Inherited
SH2 domain0.5291Inherited
Skp1 dimerisation domain-like0.6692Inherited
Clavaminate synthase-like0.7312Inherited
Second domain of FERM0.7399Inherited
Periplasmic binding protein-like II0.7785Inherited
Ribonuclease H-like0.8504Inherited
Nuclear receptor ligand-binding domain0.8781Inherited
Snake toxin-like0.8814Inherited
Immunoglobulin0.9807Inherited
Periplasmic binding protein-like I1Inherited
F-box domain1Inherited
Cytochrome P4501Inherited
Nucleotide cyclase1Inherited
alpha/beta-Hydrolases1Inherited
RNI-like1Inherited
POZ domain1Inherited
PapD-like1Inherited
Voltage-gated potassium channels1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Trunk domain of Sec23/240Direct
Ribosomal protein L10Direct
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta0Direct
Integrin domains0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain0Direct
DEATH domain, DD0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
LEM domain0Direct
Acyl-carrier protein (ACP)0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Hsp90 middle domain0Direct
S-adenosylmethionine synthetase0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Helical domain of Sec23/240Direct
Thiolase-related0Direct
HCDH C-domain-like0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
p120GAP domain-like0Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
HSP90 C-terminal domain0Direct
beta-sandwich domain of Sec23/240Direct
Cullin repeat0Direct
Lesion bypass DNA polymerase (Y-family), catalytic domain0Direct
HSP200Direct
Group II chaperonin (CCT, TRIC), ATPase domain0Direct
Anticodon-binding domain of Class II aaRS0Direct
CAT-like0Direct
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain0Direct
L30e/L7ae ribosomal proteins0Direct
Smc hinge domain0Direct
PEP carboxykinase C-terminal domain0Direct
Cu,Zn superoxide dismutase-like0Direct
F1F0 ATP synthase subunit C0Direct
Branched-chain alpha-keto acid dehydrogenase PP module0Direct
Vertebrate phospholipase A20Direct
Mammalian PLC0Direct
Sec1/munc18-like (SM) proteins0Direct
SCF ubiquitin ligase complex WHB domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
POU-specific domain0Direct
Erythroid transcription factor GATA-10Direct
Clathrin coat assembly domain0Direct
Lactate & malate dehydrogenases, C-terminal domain0Direct
RNA-polymerase beta0Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
LDH N-terminal domain-like0Direct
PDI-like0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
ets domain0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
Oxysterol-binding protein0Direct
a tRNA synthase domain0Direct
Sir2 family of transcriptional regulators0Direct
Chromo domain0Direct
Proteasome subunits0Direct
FF domain0Direct
14-3-3 protein0Direct
SMAD MH1 domain0Direct
Tubulin, C-terminal domain0Direct
MIF4G domain-like0Direct
Quinoprotein alcohol dehydrogenase-like0Direct
Clathrin adaptor core protein0Direct
Tubulin, GTPase domain0Direct
Heme-dependent catalases0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Brix domain0Direct
Nop domain0Direct
Histone deacetylase, HDAC0Direct
Cullin homology domain0Direct
MIR domain0Direct
Adenain-like0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
PEP carboxykinase N-terminal domain0Direct
RNA editing terminal uridyl transferase 2, RET2, domain 20Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
Zn-finger domain of Sec23/240Direct
RecA protein-like (ATPase-domain)0Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Group II chaperonin (CCT, TRIC), apical domain0Direct
Nucleosome core histones0.000000001696Direct
Homeodomain0.0000004161Direct
Actin/HSP700.000001287Direct
UBC-related0.000001822Direct
Forkhead DNA-binding domain0.000002814Direct
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.0000125Direct
PHD domain0.00001557Direct
Pepsin-like0.00002744Direct
G proteins0.00006398Direct
Pleckstrin-homology domain (PH domain)0.0001183Direct
Chaperone J-domain0.0001292Direct
Dual specificity phosphatase-like0.0001506Direct
RING finger domain, C3HC40.000217Direct
Histone lysine methyltransferases0.0002921Direct
Fatty acid binding protein-like0.0003051Direct
Canonical RBD0.000322Direct
Papain-like0.0005944Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.0005951Direct
Ubiquitin carboxyl-terminal hydrolase, UCH0.0006084Direct
PLC-like (P variant)0.0006246Direct
Tetratricopeptide repeat (TPR)0.000644Direct
Hect, E3 ligase catalytic domain0.0009655Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.0012Inherited
Bromodomain0.0012Inherited
Ubiquitin-related0.001291Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.0013Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.002035Inherited
WD40-repeat0.003047Inherited
Armadillo repeat0.003896Inherited
HLH, helix-loop-helix DNA-binding domain0.004833Inherited
B-box zinc-binding domain0.005076Inherited
Heat shock protein 70kD (HSP70), peptide-binding domain0.00526Inherited
Translational machinery components0.00526Inherited
SMAD domain0.00526Inherited
Cyclophilin (peptidylprolyl isomerase)0.009123Inherited
acyl-CoA oxidase N-terminal domains0.01061Inherited
acyl-CoA oxidase C-terminal domains0.01061Inherited
CCCH zinc finger0.01428Inherited
Cold shock DNA-binding domain-like0.01491Inherited
Lipovitellin-phosvitin complex, superhelical domain0.02132Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.02132Inherited
Gastric lipase0.02279Inherited
Calpain large subunit, middle domain (domain III)0.02279Inherited
Crotonase-like0.02322Inherited
TBP-associated factors, TAFs0.02322Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP0.02322Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.02487Inherited
Transforming growth factor (TGF)-beta0.02504Inherited
EF-hand modules in multidomain proteins0.02504Inherited
Frizzled cysteine-rich domain0.02504Inherited
Extended PAW domain0.02812Inherited
FKBP immunophilin/proline isomerase0.0329Inherited
LIM domain0.0329Inherited
Intermediate filament protein, coiled coil region0.03983Inherited
Ubiquitin activating enzymes (UBA)0.04271Inherited
Class I alpha-1;2-mannosidase, catalytic domain0.04532Inherited
Extended AAA-ATPase domain0.04882Inherited
Cdc48 N-terminal domain-like0.05553Inherited
MIT domain0.05553Inherited
Bacterial lipase0.05553Inherited
Pumilio repeat0.0668Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0668Inherited
Choline/Carnitine O-acyltransferase0.07121Inherited
Elongation factors0.07979Inherited
Cyclin0.07979Inherited
Biotin dependent carboxylase carboxyltransferase domain0.0844Inherited
Anticodon-binding domain0.0844Inherited
WWE domain0.0844Inherited
Cdc48 domain 2-like0.0844Inherited
Leucine zipper domain0.09482Inherited
PAZ domain0.09542Inherited
6-phosphogluconate dehydrogenase-like, N-terminal domain0.103Inherited
PDZ domain0.105Inherited
Lamin A/C globular tail domain0.1098Inherited
Biotinyl/lipoyl-carrier proteins and domains0.1337Inherited
PX domain0.1337Inherited
Glutathione S-transferase (GST), N-terminal domain0.1362Inherited
Transducin (alpha subunit), insertion domain0.1519Inherited
Acetyl-CoA synthetase-like0.1756Inherited
Spectrin repeat0.2034Inherited
GABA-aminotransferase-like0.2034Inherited
DEP domain0.2345Inherited
Glutathione S-transferase (GST), C-terminal domain0.3241Inherited
I set domains0.3509Inherited
SH3-domain0.3679Inherited
First domain of FERM0.4073Inherited
Calmodulin-like0.4334Inherited
N-acetyl transferase, NAT0.5603Inherited
Double-stranded RNA-binding domain (dsRBD)0.5613Inherited
Calpain large subunit, catalytic domain (domain II)0.6573Inherited
Synaptotagmin-like (S variant)0.6787Inherited
Third domain of FERM0.6885Inherited
Phosphate binding protein-like0.7696Inherited
Second domain of FERM0.8291Inherited
SH2 domain0.8717Inherited
Thioltransferase0.8919Inherited
Skp1 dimerisation domain-like0.9244Inherited
Acetylcholinesterase-like1Inherited
F-box domain1Inherited
Voltage-gated potassium channels1Inherited
Adenylyl and guanylyl cyclase catalytic domain1Inherited
Protein kinases, catalytic subunit1Inherited
Cytochrome P4501Inherited
MSP-like1Inherited
Nuclear receptor1Inherited
BTB/POZ domain1Inherited
Nuclear receptor ligand-binding domain1Inherited


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Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
14-3-3 protein0Direct
Thiolase-like0Direct
Oxysterol-binding protein-like0Direct
GroEL equatorial domain-like0Direct
Putative DNA-binding domain0Direct
Tubulin nucleotide-binding domain-like0Direct
Cullin homology domain0Direct
Ribosomal protein L10Direct
PEP carboxykinase-like0Direct
TK C-terminal domain-like0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Class II aaRS ABD-related0Direct
FF domain0Direct
LEM domain0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
F1F0 ATP synthase subunit C0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
LDH C-terminal domain-like0Direct
Cu,Zn superoxide dismutase-like0Direct
PEP carboxykinase N-terminal domain0Direct
Cytochrome c0Direct
S-adenosylmethionine synthetase0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
ISP domain0Direct
MIR domain0Direct
HSP90 C-terminal domain0Direct
Sec1/munc18-like (SM) proteins0Direct
Clathrin adaptor appendage domain0Direct
Ribosomal protein L10-like0Direct
Ribosomal proteins S24e, L23 and L15e0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Zn-finger domain of Sec23/240Direct
GroEL apical domain-like0Direct
SMAD MH1 domain0Direct
Heme-dependent catalase-like0Direct
Helical domain of Sec23/240Direct
L-aspartase-like0Direct
JAB1/MPN domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Nop domain0Direct
ValRS/IleRS/LeuRS editing domain0Direct
GroEL-intermediate domain like0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
Tubulin C-terminal domain-like0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
Histone-fold0.0000000000002074Direct
RING/U-box0.0000000000003515Direct
ARM repeat0.000000000002258Direct
"Winged helix" DNA-binding domain0.000000000002363Direct
Cysteine proteinases0.00000002531Direct
P-loop containing nucleoside triphosphate hydrolases0.00000004071Direct
UBC-like0.00000005496Direct
Chromo domain-like0.00000005583Direct
HSP20-like chaperones0.0000001301Direct
Homeodomain-like0.0000001981Direct
RNA-binding domain, RBD0.0000003398Direct
WD40 repeat-like0.0000004744Direct
FYVE/PHD zinc finger0.00000159Direct
SET domain0.000002498Direct
Acyl-CoA dehydrogenase NM domain-like0.000004483Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.000004483Direct
Chaperone J-domain0.00000557Direct
Class II aaRS and biotin synthetases0.00002648Direct
SNARE-like0.00004379Direct
Acid proteases0.00004583Direct
PH domain-like0.00008634Direct
Cysteine-rich domain0.0001094Direct
Bromodomain0.0002074Direct
Actin-like ATPase domain0.0002142Direct
Hect, E3 ligase catalytic domain0.0002605Direct
Translation proteins SH3-like domain0.0002722Direct
CoA-dependent acyltransferases0.0003159Direct
Nucleotidylyl transferase0.0003427Direct
HLH, helix-loop-helix DNA-binding domain0.0003766Direct
Translation proteins0.0004043Direct
PAP/OAS1 substrate-binding domain0.0004346Direct
beta-beta-alpha zinc fingers0.0005568Direct
Nucleotidyltransferase0.0007306Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.0007943Direct
Cullin repeat-like0.0007943Direct
Arginase/deacetylase0.0007943Direct
B-box zinc-binding domain0.0009062Direct
Ubiquitin-like0.001031Inherited
HMG-box0.001446Inherited
ClpP/crotonase0.001446Inherited
Activating enzymes of the ubiquitin-like proteins0.001854Inherited
PYP-like sensor domain (PAS domain)0.001854Inherited
Cyclophilin-like0.0019Inherited
CCCH zinc finger0.002184Inherited
Nucleic acid-binding proteins0.002245Inherited
Galactose-binding domain-like0.002542Inherited
ACP-like0.004309Inherited
Sm-like ribonucleoproteins0.004363Inherited
Retrovirus zinc finger-like domains0.005439Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.00803Inherited
Calpain large subunit, middle domain (domain III)0.00912Inherited
Riboflavin synthase domain-like0.00912Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.00912Inherited
L30e-like0.009599Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.009599Inherited
beta and beta-prime subunits of DNA dependent RNA-polymerase0.009928Inherited
Lipovitellin-phosvitin complex, superhelical domain0.009928Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.009928Inherited
Translational machinery components0.009928Inherited
ENTH/VHS domain0.0103Inherited
Tudor/PWWP/MBT0.0103Inherited
FKBP-like0.01225Inherited
Frizzled cysteine-rich domain0.01249Inherited
4Fe-4S ferredoxins0.01249Inherited
Intermediate filament protein, coiled coil region0.01464Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.01464Inherited
UBA-like0.01528Inherited
SMAD/FHA domain0.01855Inherited
Lipocalins0.01987Inherited
Seven-hairpin glycosidases0.02095Inherited
PAZ domain0.02184Inherited
DHS-like NAD/FAD-binding domain0.02605Inherited
Leucine zipper domain0.02615Inherited
GST C-terminal domain-like0.0295Inherited
MIT domain0.03212Inherited
ADC-like0.03212Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.03986Inherited
dsRNA-binding domain-like0.03986Inherited
Zn-binding ribosomal proteins0.04035Inherited
Transducin (alpha subunit), insertion domain0.04999Inherited
Cyclin-like0.05133Inherited
Acetyl-CoA synthetase-like0.05147Inherited
Cdc48 domain 2-like0.05158Inherited
Integrin domains0.05158Inherited
WWE domain0.05158Inherited
HIT/MYND zinc finger-like0.05417Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.05519Inherited
Saposin0.0599Inherited
Single hybrid motif0.06186Inherited
PX domain0.06186Inherited
Spectrin repeat0.06186Inherited
Lamin A/C globular tail domain0.06186Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.07092Inherited
p53-like transcription factors0.07724Inherited
SH3-domain0.08862Inherited
FAD/NAD(P)-binding domain0.09153Inherited
DNA/RNA polymerases0.09438Inherited
S15/NS1 RNA-binding domain0.1022Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.1151Inherited
Thioredoxin-like0.145Inherited
CAD & PB1 domains0.154Inherited
ARID-like0.154Inherited
HSP40/DnaJ peptide-binding domain0.154Inherited
Tubby C-terminal domain-like0.154Inherited
Calcium ATPase, transmembrane domain M0.1634Inherited
KA1-like0.2021Inherited
EF-hand0.2043Inherited
DNase I-like0.2274Inherited
Quinoprotein alcohol dehydrogenase-like0.2378Inherited
SAM/Pointed domain0.2859Inherited
Eukaryotic type KH-domain (KH-domain type I)0.286Inherited
PLC-like phosphodiesterases0.3622Inherited
GTPase activation domain, GAP0.3694Inherited
Insulin-like0.3769Inherited
Protein kinase-like (PK-like)0.4372Inherited
PDZ domain-like0.4731Inherited
SH2 domain0.5071Inherited
Skp1 dimerisation domain-like0.6477Inherited
Clavaminate synthase-like0.7109Inherited
Second domain of FERM0.7199Inherited
Periplasmic binding protein-like II0.7596Inherited
Ribonuclease H-like0.8335Inherited
Nuclear receptor ligand-binding domain0.8622Inherited
Snake toxin-like0.8657Inherited
Immunoglobulin0.9693Inherited
RNI-like1Inherited
Nucleotide cyclase1Inherited
Voltage-gated potassium channels1Inherited
F-box domain1Inherited
Cytochrome P4501Inherited
POZ domain1Inherited
PapD-like1Inherited
Periplasmic binding protein-like I1Inherited
alpha/beta-Hydrolases1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0Direct
    46785,46785
  • 46785 - "Winged helix" DNA-binding domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    52518,52922
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 0Direct
    53901,53901
  • 53901 - Thiolase-like
  • 53901 - Thiolase-like
  • 0Direct
    51735,56327
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 56327 - LDH C-terminal domain-like
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    57903,82199
  • 57903 - FYVE/PHD zinc finger
  • 82199 - SET domain
  • 0Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    144232,82199
  • 144232 - HIT/MYND zinc finger-like
  • 82199 - SET domain
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    68923,53795
  • 68923 - PEP carboxykinase N-terminal domain
  • 53795 - PEP carboxykinase-like
  • 0Direct
    48179,48179
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    51905,56425
  • 51905 - FAD/NAD(P)-binding domain
  • 56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
  • 0Direct
    55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    57863,48403
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0Direct
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0Direct
    49348,55711
  • 49348 - Clathrin adaptor appendage domain
  • 55711 - Subdomain of clathrin and coatomer appendage domain
  • 0Direct
    64356,49447
  • 64356 - SNARE-like
  • 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor
  • 0Direct
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0Direct
    81698,81698
  • 81698 - FF domain
  • 81698 - FF domain
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    81383,50978
  • 81383 - F-box domain
  • 50978 - WD40 repeat-like
  • 0Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0Direct
    55729,55729
  • 55729 - Acyl-CoA N-acyltransferases (Nat)
  • 55729 - Acyl-CoA N-acyltransferases (Nat)
  • 0Direct
    57756,57756
  • 57756 - Retrovirus zinc finger-like domains
  • 57756 - Retrovirus zinc finger-like domains
  • 0Direct
    56672,100879
  • 56672 - DNA/RNA polymerases
  • 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.000001711Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.000004483Direct
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.000006228Direct
    81301,81631
  • 81301 - Nucleotidyltransferase
  • 81631 - PAP/OAS1 substrate-binding domain
  • 0.0002065Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.0002065Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.0004346Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.0007943Direct
    101690,53098
  • 101690 - PAZ domain
  • 53098 - Ribonuclease H-like
  • 0.001832Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.002655Inherited
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0.004309Inherited
    47203,47203
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.004309Inherited
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0.004309Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.004799Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.005724Inherited
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.007501Inherited
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.009599Inherited
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.009599Inherited
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.009928Inherited
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0.009928Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.01283Inherited
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0.01429Inherited
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0.01552Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.02095Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.02184Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.02272Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.03212Inherited
    51735,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0.03986Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.04035Inherited
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.04035Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04999Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 0.07043Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.07453Inherited
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.09438Inherited
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0.1022Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.1151Inherited
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.154Inherited
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0.1582Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.1782Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.3478Inherited
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.5856Inherited
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.6823Inherited
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0.8035Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9666Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    51735,48179,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    55973,55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    48452,48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0Direct
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    48371,48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.0002605Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.0007943Direct
    56645,47203,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.004309Inherited
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.005627Inherited
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.009599Inherited
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.009928Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.009928Inherited
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.02605Inherited
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.1678Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.1728Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.2754Inherited
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.7234Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.8581Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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