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Worm Phenotype (WP): organism metabolism processing variant

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Variant [WBPhenotype:0000886] <2>
+ + + 3:   physiology variant [WBPhenotype:0000519] <14>(510|587) (510|248|68)
+ + 2:   organism physiology variant [WBPhenotype:0000576] <9>(369|431) (372|193|56)
+ 1:   organism homeostasis metabolism variant [WBPhenotype:0000577] <16>(361|421) (363|190|55)
0:   organism metabolism processing variant [WBPhenotype:0000027] <25>(178|190) (182|87|26)
- 1:   gene expression variant [WBPhenotype:0000717] <11>(127|139) (131|64|20)
- 1:   lipid metabolism variant [WBPhenotype:0000725] <8>(19|27) (21|8|4)
- 1:   metabolic pathway variant [WBPhenotype:0000463] <8>(39|32) (39|15|9)
- 1:   diet response variant [WBPhenotype:0002525] <5>(0|0) (0|0|0)
- 1:   enzyme activity variant [WBPhenotype:0000727] <5>(6|6) (6|1|0)
- 1:   neurotransmitter metabolism variant [WBPhenotype:0000221] <4>(0|0) (0|0|0)
- 1:   protein interaction variant [WBPhenotype:0001369] <4>(47|49) (48|21|9)
- 1:   ATP levels variant [WBPhenotype:0001574] <2>(2|2) (2|1|0)
- 1:   biogenic amine physiology variant [WBPhenotype:0001518] <2>(0|0) (0|0|0)
- 1:   heme levels variant [WBPhenotype:0002480] <2>(0|0) (0|0|0)
- 1:   energy expenditure variant [WBPhenotype:0001835] <1>(0|0) (0|0|0)
- 1:   glutathione levels variant [WBPhenotype:0001899] <1>(1|1) (1|0|0)
- 1:   neuropeptide metabolism variant [WBPhenotype:0001757] <1>(0|0) (0|0|0)
- 1:   post translational processing variant [WBPhenotype:0000122] <1>(0|0) (0|0|0)
- 1:   GABA levels variant [WBPhenotype:0000552](0|0) (0|0|0)
- 1:   acetylcholine levels variant [WBPhenotype:0000507](0|0) (0|0|0)
- 1:   carbohydrate metabolism variant [WBPhenotype:0002072](0|0) (0|0|0)
- 1:   galactose metabolism variant [WBPhenotype:0002206](0|0) (0|0|0)
- 1:   glucose intolerant [WBPhenotype:0002400](0|0) (0|0|0)
- 1:   glycation variant [WBPhenotype:0002008](0|0) (0|0|0)
- 1:   glycogen levels variant [WBPhenotype:0001892](0|0) (0|0|0)
- 1:   hormone metabolism variant [WBPhenotype:0001843](0|0) (0|0|0)
- 1:   hypersensitive to galactose [WBPhenotype:0002205](0|0) (0|0|0)
- 1:   nonsense mRNA accumulation [WBPhenotype:0000508](2|1) (2|0|0)
- 1:   pheromone production variant [WBPhenotype:0002381](0|0) (0|0|0)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
F1F0 ATP synthase subunit C0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
FF domain0Direct
JAB1/MPN domain0Direct
Ribosomal protein L10-like0Direct
Helical domain of Sec23/240Direct
TK C-terminal domain-like0Direct
Ribosomal proteins S24e, L23 and L15e0Direct
Cytochrome c0Direct
GroEL-intermediate domain like0Direct
GroEL equatorial domain-like0Direct
MIR domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
LDH C-terminal domain-like0Direct
LEM domain0Direct
Sec1/munc18-like (SM) proteins0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Class II aaRS ABD-related0Direct
Heme-dependent catalase-like0Direct
14-3-3 protein0Direct
Cu,Zn superoxide dismutase-like0Direct
Oxysterol-binding protein-like0Direct
Ribosomal protein L10Direct
L-aspartase-like0Direct
Zn-finger domain of Sec23/240Direct
S-adenosylmethionine synthetase0Direct
ValRS/IleRS/LeuRS editing domain0Direct
ISP domain0Direct
Nop domain0Direct
SMAD MH1 domain0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Cullin homology domain0Direct
Clathrin adaptor appendage domain0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
Tubulin C-terminal domain-like0Direct
PEP carboxykinase N-terminal domain0Direct
Putative DNA-binding domain0Direct
GroEL apical domain-like0Direct
HSP90 C-terminal domain0Direct
Tubulin nucleotide-binding domain-like0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
PEP carboxykinase-like0Direct
Thiolase-like0Direct
Histone-fold0.0000000000002856Direct
RING/U-box0.000000000000286Direct
ARM repeat0.000000000003181Direct
"Winged helix" DNA-binding domain0.000000000003236Direct
P-loop containing nucleoside triphosphate hydrolases0.00000001687Direct
Cysteine proteinases0.00000003358Direct
UBC-like0.00000007107Direct
Chromo domain-like0.0000000716Direct
RNA-binding domain, RBD0.0000001426Direct
HSP20-like chaperones0.0000001668Direct
Homeodomain-like0.0000002635Direct
WD40 repeat-like0.00000063Direct
FYVE/PHD zinc finger0.00000204Direct
SET domain0.000003172Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.000005652Direct
Acyl-CoA dehydrogenase NM domain-like0.000005652Direct
Chaperone J-domain0.000007062Direct
Class II aaRS and biotin synthetases0.00003309Direct
SNARE-like0.00005437Direct
Acid proteases0.00005718Direct
PH domain-like0.0001107Direct
Cysteine-rich domain0.0001368Direct
Bromodomain0.000256Direct
Actin-like ATPase domain0.000267Direct
Hect, E3 ligase catalytic domain0.0003199Direct
Translation proteins SH3-like domain0.0003349Direct
CoA-dependent acyltransferases0.0003892Direct
Nucleotidylyl transferase0.0004235Direct
HLH, helix-loop-helix DNA-binding domain0.000467Direct
Translation proteins0.0004984Direct
PAP/OAS1 substrate-binding domain0.0005337Direct
beta-beta-alpha zinc fingers0.0006987Direct
Nucleotidyltransferase0.0008933Direct
Arginase/deacetylase0.0009659Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.0009659Direct
Cullin repeat-like0.0009659Direct
B-box zinc-binding domain0.001105Inherited
Ubiquitin-like0.001275Inherited
ClpP/crotonase0.001755Inherited
HMG-box0.001755Inherited
Activating enzymes of the ubiquitin-like proteins0.00223Inherited
PYP-like sensor domain (PAS domain)0.00223Inherited
Cyclophilin-like0.002293Inherited
CCCH zinc finger0.002641Inherited
Nucleic acid-binding proteins0.002737Inherited
Galactose-binding domain-like0.003072Inherited
ACP-like0.005115Inherited
Sm-like ribonucleoproteins0.005205Inherited
Retrovirus zinc finger-like domains0.006463Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.00951Inherited
Calpain large subunit, middle domain (domain III)0.01068Inherited
Riboflavin synthase domain-like0.01068Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.01068Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.01125Inherited
L30e-like0.01125Inherited
Lipovitellin-phosvitin complex, superhelical domain0.01161Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.01161Inherited
Translational machinery components0.01161Inherited
beta and beta-prime subunits of DNA dependent RNA-polymerase0.01161Inherited
Tudor/PWWP/MBT0.01208Inherited
FKBP-like0.01428Inherited
4Fe-4S ferredoxins0.01451Inherited
Frizzled cysteine-rich domain0.01451Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.01702Inherited
Intermediate filament protein, coiled coil region0.01702Inherited
UBA-like0.01783Inherited
SMAD/FHA domain0.02159Inherited
Lipocalins0.02308Inherited
Seven-hairpin glycosidases0.02416Inherited
PAZ domain0.0253Inherited
DHS-like NAD/FAD-binding domain0.0299Inherited
Leucine zipper domain0.03012Inherited
GST C-terminal domain-like0.0342Inherited
ADC-like0.03665Inherited
MIT domain0.03665Inherited
dsRNA-binding domain-like0.04552Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.04552Inherited
Zn-binding ribosomal proteins0.04594Inherited
Transducin (alpha subunit), insertion domain0.05686Inherited
WWE domain0.05826Inherited
Cdc48 domain 2-like0.05826Inherited
Integrin domains0.05826Inherited
Cyclin-like0.05837Inherited
Acetyl-CoA synthetase-like0.05856Inherited
HIT/MYND zinc finger-like0.06132Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.06286Inherited
Saposin0.06781Inherited
PX domain0.06973Inherited
Spectrin repeat0.06973Inherited
Lamin A/C globular tail domain0.06973Inherited
Single hybrid motif0.06973Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.08178Inherited
p53-like transcription factors0.08677Inherited
SH3-domain0.09964Inherited
FAD/NAD(P)-binding domain0.1026Inherited
DNA/RNA polymerases0.1051Inherited
S15/NS1 RNA-binding domain0.1133Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.1278Inherited
Thioredoxin-like0.1617Inherited
ARID-like0.1688Inherited
Tubby C-terminal domain-like0.1688Inherited
CAD & PB1 domains0.1688Inherited
HSP40/DnaJ peptide-binding domain0.1688Inherited
Calcium ATPase, transmembrane domain M0.1792Inherited
KA1-like0.2195Inherited
EF-hand0.224Inherited
Eukaryotic type KH-domain (KH-domain type I)0.256Inherited
Quinoprotein alcohol dehydrogenase-like0.2573Inherited
SAM/Pointed domain0.307Inherited
GTPase activation domain, GAP0.3922Inherited
Protein kinase-like (PK-like)0.4908Inherited
PDZ domain-like0.4984Inherited
SH2 domain0.5325Inherited
Skp1 dimerisation domain-like0.671Inherited
Clavaminate synthase-like0.7331Inherited
Second domain of FERM0.7416Inherited
Periplasmic binding protein-like II0.7803Inherited
Ribonuclease H-like0.8533Inherited
Snake toxin-like0.8826Inherited
Nuclear receptor ligand-binding domain0.8829Inherited
Immunoglobulin0.9824Inherited
PapD-like1Inherited
alpha/beta-Hydrolases1Inherited
POZ domain1Inherited
Voltage-gated potassium channels1Inherited
RNI-like1Inherited
Cytochrome P4501Inherited
Periplasmic binding protein-like I1Inherited
F-box domain1Inherited
Nucleotide cyclase1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
POU-specific domain0Direct
PDI-like0Direct
Thiolase-related0Direct
CAT-like0Direct
RNA editing terminal uridyl transferase 2, RET2, domain 20Direct
MIR domain0Direct
Ribosomal protein L10Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Nop domain0Direct
beta-sandwich domain of Sec23/240Direct
a tRNA synthase domain0Direct
PEP carboxykinase C-terminal domain0Direct
Sir2 family of transcriptional regulators0Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
Brix domain0Direct
Heme-dependent catalases0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
FF domain0Direct
Cullin repeat0Direct
Hsp90 middle domain0Direct
Lesion bypass DNA polymerase (Y-family), catalytic domain0Direct
Tubulin, GTPase domain0Direct
Cu,Zn superoxide dismutase-like0Direct
Quinoprotein alcohol dehydrogenase-like0Direct
Helical domain of Sec23/240Direct
L30e/L7ae ribosomal proteins0Direct
Smc hinge domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Lactate & malate dehydrogenases, C-terminal domain0Direct
Acyl-carrier protein (ACP)0Direct
Group II chaperonin (CCT, TRIC), apical domain0Direct
Sec1/munc18-like (SM) proteins0Direct
Zn-finger domain of Sec23/240Direct
SCF ubiquitin ligase complex WHB domain0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
HSP200Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
Vertebrate phospholipase A20Direct
Clathrin adaptor core protein0Direct
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain0Direct
RNA-polymerase beta0Direct
14-3-3 protein0Direct
p120GAP domain-like0Direct
Proteasome subunits0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Histone deacetylase, HDAC0Direct
Clathrin coat assembly domain0Direct
Erythroid transcription factor GATA-10Direct
Mammalian PLC0Direct
Chromo domain0Direct
LEM domain0Direct
PEP carboxykinase N-terminal domain0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Cullin homology domain0Direct
DEATH domain, DD0Direct
Trunk domain of Sec23/240Direct
Adenain-like0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain0Direct
SMAD MH1 domain0Direct
HSP90 C-terminal domain0Direct
Group II chaperonin (CCT, TRIC), ATPase domain0Direct
Branched-chain alpha-keto acid dehydrogenase PP module0Direct
F1F0 ATP synthase subunit C0Direct
MIF4G domain-like0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Integrin domains0Direct
LDH N-terminal domain-like0Direct
HCDH C-domain-like0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
ets domain0Direct
S-adenosylmethionine synthetase0Direct
Oxysterol-binding protein0Direct
Tubulin, C-terminal domain0Direct
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta0Direct
RecA protein-like (ATPase-domain)0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
Anticodon-binding domain of Class II aaRS0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Nucleosome core histones0.000000001793Direct
Homeodomain0.000000437Direct
Actin/HSP700.000001319Direct
UBC-related0.000001867Direct
Forkhead DNA-binding domain0.000002863Direct
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.00001272Direct
PHD domain0.00001587Direct
Pepsin-like0.0000279Direct
G proteins0.00006721Direct
Pleckstrin-homology domain (PH domain)0.0001213Direct
Canonical RBD0.0001279Direct
Chaperone J-domain0.0001322Direct
Dual specificity phosphatase-like0.000153Direct
RING finger domain, C3HC40.0002224Direct
Histone lysine methyltransferases0.0002964Direct
Fatty acid binding protein-like0.000309Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.0006031Direct
Papain-like0.0006052Direct
Ubiquitin carboxyl-terminal hydrolase, UCH0.0006187Direct
PLC-like (P variant)0.000632Direct
Tetratricopeptide repeat (TPR)0.000659Direct
Hect, E3 ligase catalytic domain0.0009747Direct
Bromodomain0.001215Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.001215Inherited
Ubiquitin-related0.001314Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.001318Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.002063Inherited
WD40-repeat0.00315Inherited
Armadillo repeat0.003939Inherited
HLH, helix-loop-helix DNA-binding domain0.004923Inherited
B-box zinc-binding domain0.005135Inherited
SMAD domain0.005303Inherited
Translational machinery components0.005303Inherited
Heat shock protein 70kD (HSP70), peptide-binding domain0.005303Inherited
Cyclophilin (peptidylprolyl isomerase)0.009224Inherited
acyl-CoA oxidase C-terminal domains0.01069Inherited
acyl-CoA oxidase N-terminal domains0.01069Inherited
CCCH zinc finger0.01449Inherited
Cold shock DNA-binding domain-like0.01508Inherited
Lipovitellin-phosvitin complex, superhelical domain0.02145Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.02145Inherited
Calpain large subunit, middle domain (domain III)0.02293Inherited
Gastric lipase0.02293Inherited
Crotonase-like0.02343Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP0.02343Inherited
TBP-associated factors, TAFs0.02343Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.02506Inherited
Transforming growth factor (TGF)-beta0.02517Inherited
Frizzled cysteine-rich domain0.02517Inherited
EF-hand modules in multidomain proteins0.02517Inherited
Extended PAW domain0.02835Inherited
FKBP immunophilin/proline isomerase0.03312Inherited
LIM domain0.03312Inherited
Intermediate filament protein, coiled coil region0.04012Inherited
Ubiquitin activating enzymes (UBA)0.04292Inherited
Class I alpha-1;2-mannosidase, catalytic domain0.04557Inherited
Extended AAA-ATPase domain0.04952Inherited
Bacterial lipase0.05573Inherited
MIT domain0.05573Inherited
Cdc48 N-terminal domain-like0.05573Inherited
Pumilio repeat0.06724Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.06724Inherited
Choline/Carnitine O-acyltransferase0.07165Inherited
Cyclin0.08045Inherited
Elongation factors0.08045Inherited
Cdc48 domain 2-like0.08473Inherited
Anticodon-binding domain0.08473Inherited
WWE domain0.08473Inherited
Biotin dependent carboxylase carboxyltransferase domain0.08473Inherited
Leucine zipper domain0.09558Inherited
PAZ domain0.09626Inherited
6-phosphogluconate dehydrogenase-like, N-terminal domain0.1037Inherited
PDZ domain0.1062Inherited
Lamin A/C globular tail domain0.1104Inherited
Biotinyl/lipoyl-carrier proteins and domains0.1345Inherited
PX domain0.1345Inherited
Glutathione S-transferase (GST), N-terminal domain0.1379Inherited
Transducin (alpha subunit), insertion domain0.1531Inherited
Acetyl-CoA synthetase-like0.1771Inherited
Spectrin repeat0.2044Inherited
GABA-aminotransferase-like0.2044Inherited
DEP domain0.2352Inherited
Glutathione S-transferase (GST), C-terminal domain0.3266Inherited
I set domains0.3526Inherited
SH3-domain0.3708Inherited
First domain of FERM0.4083Inherited
Calmodulin-like0.4362Inherited
N-acetyl transferase, NAT0.5616Inherited
Double-stranded RNA-binding domain (dsRBD)0.5625Inherited
Calpain large subunit, catalytic domain (domain II)0.6591Inherited
Synaptotagmin-like (S variant)0.6802Inherited
Third domain of FERM0.6893Inherited
Phosphate binding protein-like0.7708Inherited
Second domain of FERM0.8305Inherited
SH2 domain0.8739Inherited
Thioltransferase0.8927Inherited
Skp1 dimerisation domain-like0.9255Inherited
Adenylyl and guanylyl cyclase catalytic domain1Inherited
F-box domain1Inherited
Nuclear receptor1Inherited
BTB/POZ domain1Inherited
MSP-like1Inherited
Acetylcholinesterase-like1Inherited
Nuclear receptor ligand-binding domain1Inherited
Voltage-gated potassium channels1Inherited
Protein kinases, catalytic subunit1Inherited
Cytochrome P4501Inherited


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Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Ribosomal protein L10-like0Direct
F1F0 ATP synthase subunit C0Direct
GroEL equatorial domain-like0Direct
PEP carboxykinase-like0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Clathrin adaptor appendage domain0Direct
Cullin homology domain0Direct
Heme-dependent catalase-like0Direct
Oxysterol-binding protein-like0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
14-3-3 protein0Direct
L-aspartase-like0Direct
S-adenosylmethionine synthetase0Direct
Ribosomal proteins S24e, L23 and L15e0Direct
Tubulin C-terminal domain-like0Direct
LEM domain0Direct
PEP carboxykinase N-terminal domain0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
SMAD MH1 domain0Direct
HSP90 C-terminal domain0Direct
JAB1/MPN domain0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
GroEL apical domain-like0Direct
Class II aaRS ABD-related0Direct
Thiolase-like0Direct
Tubulin nucleotide-binding domain-like0Direct
Ribosomal protein L10Direct
GroEL-intermediate domain like0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
Helical domain of Sec23/240Direct
FF domain0Direct
Sec1/munc18-like (SM) proteins0Direct
Nop domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
ISP domain0Direct
LDH C-terminal domain-like0Direct
Cytochrome c0Direct
MIR domain0Direct
TK C-terminal domain-like0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Zn-finger domain of Sec23/240Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Putative DNA-binding domain0Direct
Cu,Zn superoxide dismutase-like0Direct
Histone-fold0.0000000000002245Direct
RING/U-box0.0000000000002249Direct
ARM repeat0.000000000002509Direct
"Winged helix" DNA-binding domain0.000000000002552Direct
P-loop containing nucleoside triphosphate hydrolases0.00000001346Direct
Cysteine proteinases0.00000002685Direct
UBC-like0.00000005689Direct
Chromo domain-like0.00000005733Direct
RNA-binding domain, RBD0.0000001143Direct
HSP20-like chaperones0.0000001339Direct
Homeodomain-like0.0000002119Direct
WD40 repeat-like0.0000005083Direct
FYVE/PHD zinc finger0.000001654Direct
SET domain0.000002575Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.000004596Direct
Acyl-CoA dehydrogenase NM domain-like0.000004596Direct
Chaperone J-domain0.000005743Direct
Class II aaRS and biotin synthetases0.00002702Direct
SNARE-like0.00004451Direct
Acid proteases0.00004679Direct
PH domain-like0.00009075Direct
Cysteine-rich domain0.0001122Direct
Bromodomain0.0002106Direct
Actin-like ATPase domain0.0002198Direct
Hect, E3 ligase catalytic domain0.0002636Direct
Translation proteins SH3-like domain0.000276Direct
CoA-dependent acyltransferases0.000321Direct
Nucleotidylyl transferase0.0003497Direct
HLH, helix-loop-helix DNA-binding domain0.0003862Direct
Translation proteins0.0004126Direct
PAP/OAS1 substrate-binding domain0.0004418Direct
beta-beta-alpha zinc fingers0.0005797Direct
Nucleotidyltransferase0.0007431Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.0008038Direct
Cullin repeat-like0.0008038Direct
Arginase/deacetylase0.0008038Direct
B-box zinc-binding domain0.0009203Direct
Ubiquitin-like0.001063Inherited
HMG-box0.001468Inherited
ClpP/crotonase0.001468Inherited
PYP-like sensor domain (PAS domain)0.001873Inherited
Activating enzymes of the ubiquitin-like proteins0.001873Inherited
Cyclophilin-like0.001927Inherited
CCCH zinc finger0.002225Inherited
Nucleic acid-binding proteins0.002308Inherited
Galactose-binding domain-like0.002594Inherited
ACP-like0.004346Inherited
Sm-like ribonucleoproteins0.004423Inherited
Retrovirus zinc finger-like domains0.00551Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.008169Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.009197Inherited
Calpain large subunit, middle domain (domain III)0.009197Inherited
Riboflavin synthase domain-like0.009197Inherited
L30e-like0.009691Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.009691Inherited
Translational machinery components0.01Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.01Inherited
beta and beta-prime subunits of DNA dependent RNA-polymerase0.01Inherited
Lipovitellin-phosvitin complex, superhelical domain0.01Inherited
ENTH/VHS domain0.01042Inherited
Tudor/PWWP/MBT0.01042Inherited
FKBP-like0.01236Inherited
4Fe-4S ferredoxins0.01257Inherited
Frizzled cysteine-rich domain0.01257Inherited
Intermediate filament protein, coiled coil region0.01478Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.01478Inherited
UBA-like0.01549Inherited
SMAD/FHA domain0.01881Inherited
Lipocalins0.02015Inherited
Seven-hairpin glycosidases0.02111Inherited
PAZ domain0.02213Inherited
DHS-like NAD/FAD-binding domain0.02625Inherited
Leucine zipper domain0.02645Inherited
GST C-terminal domain-like0.0301Inherited
MIT domain0.03228Inherited
ADC-like0.03228Inherited
dsRNA-binding domain-like0.04024Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.04024Inherited
Zn-binding ribosomal proteins0.04062Inherited
Transducin (alpha subunit), insertion domain0.05054Inherited
Cdc48 domain 2-like0.05183Inherited
Integrin domains0.05183Inherited
WWE domain0.05183Inherited
Cyclin-like0.05192Inherited
Acetyl-CoA synthetase-like0.0521Inherited
HIT/MYND zinc finger-like0.05462Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.05601Inherited
Saposin0.06054Inherited
Lamin A/C globular tail domain0.06231Inherited
Single hybrid motif0.06231Inherited
Spectrin repeat0.06231Inherited
PX domain0.06231Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.07342Inherited
p53-like transcription factors0.078Inherited
SH3-domain0.08996Inherited
FAD/NAD(P)-binding domain0.09267Inherited
DNA/RNA polymerases0.09503Inherited
S15/NS1 RNA-binding domain0.1026Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.1161Inherited
Thioredoxin-like0.1479Inherited
HSP40/DnaJ peptide-binding domain0.1547Inherited
Tubby C-terminal domain-like0.1547Inherited
CAD & PB1 domains0.1547Inherited
ARID-like0.1547Inherited
Calcium ATPase, transmembrane domain M0.1646Inherited
KA1-like0.2029Inherited
EF-hand0.2071Inherited
DNase I-like0.2285Inherited
Eukaryotic type KH-domain (KH-domain type I)0.2381Inherited
Quinoprotein alcohol dehydrogenase-like0.2393Inherited
SAM/Pointed domain0.2878Inherited
PLC-like phosphodiesterases0.3638Inherited
GTPase activation domain, GAP0.3717Inherited
Insulin-like0.379Inherited
Protein kinase-like (PK-like)0.4691Inherited
PDZ domain-like0.4767Inherited
SH2 domain0.5106Inherited
Skp1 dimerisation domain-like0.6496Inherited
Clavaminate synthase-like0.7128Inherited
Second domain of FERM0.7217Inherited
Periplasmic binding protein-like II0.7614Inherited
Ribonuclease H-like0.8365Inherited
Snake toxin-like0.867Inherited
Nuclear receptor ligand-binding domain0.8673Inherited
Immunoglobulin0.9708Inherited
POZ domain1Inherited
Nucleotide cyclase1Inherited
Voltage-gated potassium channels1Inherited
RNI-like1Inherited
Cytochrome P4501Inherited
alpha/beta-Hydrolases1Inherited
Periplasmic binding protein-like I1Inherited
F-box domain1Inherited
PapD-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    53901,53901
  • 53901 - Thiolase-like
  • 53901 - Thiolase-like
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0Direct
    54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    81383,50978
  • 81383 - F-box domain
  • 50978 - WD40 repeat-like
  • 0Direct
    51905,56425
  • 51905 - FAD/NAD(P)-binding domain
  • 56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    144232,82199
  • 144232 - HIT/MYND zinc finger-like
  • 82199 - SET domain
  • 0Direct
    68923,53795
  • 68923 - PEP carboxykinase N-terminal domain
  • 53795 - PEP carboxykinase-like
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    52518,52922
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0Direct
    57756,57756
  • 57756 - Retrovirus zinc finger-like domains
  • 57756 - Retrovirus zinc finger-like domains
  • 0Direct
    81698,81698
  • 81698 - FF domain
  • 81698 - FF domain
  • 0Direct
    55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    51735,56327
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 56327 - LDH C-terminal domain-like
  • 0Direct
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    55729,55729
  • 55729 - Acyl-CoA N-acyltransferases (Nat)
  • 55729 - Acyl-CoA N-acyltransferases (Nat)
  • 0Direct
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0Direct
    57903,82199
  • 57903 - FYVE/PHD zinc finger
  • 82199 - SET domain
  • 0Direct
    46785,46785
  • 46785 - "Winged helix" DNA-binding domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    48179,48179
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    56672,100879
  • 56672 - DNA/RNA polymerases
  • 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    64356,49447
  • 64356 - SNARE-like
  • 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor
  • 0Direct
    57863,48403
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0Direct
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0Direct
    49348,55711
  • 49348 - Clathrin adaptor appendage domain
  • 55711 - Subdomain of clathrin and coatomer appendage domain
  • 0Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.000001766Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.000004596Direct
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.000006362Direct
    81301,81631
  • 81301 - Nucleotidyltransferase
  • 81631 - PAP/OAS1 substrate-binding domain
  • 0.0002099Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.0002099Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.0004418Direct
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.0005316Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.0008038Direct
    101690,53098
  • 101690 - PAZ domain
  • 53098 - Ribonuclease H-like
  • 0.001849Inherited
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0.004346Inherited
    47203,47203
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.004346Inherited
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0.004346Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.004837Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.005814Inherited
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.007585Inherited
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.009691Inherited
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.009691Inherited
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0.01Inherited
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.01Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.01299Inherited
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0.01443Inherited
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0.01568Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.02111Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.02213Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.02287Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.03228Inherited
    51735,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0.04024Inherited
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.04062Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.04062Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.05054Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 0.07155Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.07519Inherited
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.09503Inherited
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0.1026Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.1161Inherited
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.1547Inherited
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0.1591Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.1793Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.3495Inherited
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.5873Inherited
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.6843Inherited
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0.8048Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9679Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    51735,48179,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    48371,48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    48452,48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    55973,55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.0002636Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.0008038Direct
    56645,47203,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.004346Inherited
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.005686Inherited
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.009691Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.01Inherited
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.01Inherited
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.02625Inherited
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.1692Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.1736Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.2767Inherited
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.7248Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.8594Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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