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Worm Phenotype (WP): progeny variant
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
Tubby C-terminal domain-like | 0 | DIRECT |
Heme-dependent catalase-like | 0 | DIRECT |
LysM domain | 0 | DIRECT |
Cystatin/monellin | 0 | DIRECT |
CBD9-like | 0 | DIRECT |
AN1-like Zinc finger | 0 | DIRECT |
Carbohydrate phosphatase | 0 | DIRECT |
ADP-ribosylation | 0 | DIRECT |
SAND domain-like | 0 | DIRECT |
R3H domain | 0 | DIRECT |
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | DIRECT |
Nucleoside diphosphate kinase, NDK | 0 | DIRECT |
Transducin (alpha subunit), insertion domain | 0 | DIRECT |
Proton glutamate symport protein | 0 | DIRECT |
Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | DIRECT |
PurM N-terminal domain-like | 0 | DIRECT |
Galactose oxidase, central domain | 0 | DIRECT |
MgtE membrane domain-like | 0 | DIRECT |
Profilin (actin-binding protein) | 0 | DIRECT |
CO dehydrogenase molybdoprotein N-domain-like | 0 | DIRECT |
WGR domain-like | 0 | DIRECT |
Doublecortin (DC) | 0 | DIRECT |
eIF4e-like | 0 | DIRECT |
DNA repair protein MutS, domain III | 0 | DIRECT |
Oxysterol-binding protein-like | 0 | DIRECT |
LEM domain | 0 | DIRECT |
PHM/PNGase F | 0 | DIRECT |
PK beta-barrel domain-like | 0 | DIRECT |
Phoshotransferase/anion transport protein | 0 | DIRECT |
VPS9 domain | 0 | DIRECT |
Creatinase/prolidase N-terminal domain | 0 | DIRECT |
Arginase/deacetylase | 0 | DIRECT |
Complement control module/SCR domain | 0 | DIRECT |
SWIB/MDM2 domain | 0 | DIRECT |
SPOC domain-like | 0 | DIRECT |
FAD-linked oxidases, C-terminal domain | 0 | DIRECT |
Rap/Ran-GAP | 0 | DIRECT |
S-adenosylmethionine synthetase | 0 | DIRECT |
Nucleoporin domain | 0 | DIRECT |
MFPT repeat-like | 0 | DIRECT |
GAS2 domain-like | 0 | DIRECT |
Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
PEP carboxykinase N-terminal domain | 0 | DIRECT |
Tricorn protease domain 2 | 0 | DIRECT |
Hormone receptor domain | 0 | DIRECT |
ARID-like | 0 | DIRECT |
GAT-like domain | 0 | DIRECT |
Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
14-3-3 protein | 0 | DIRECT |
Nop domain | 0 | DIRECT |
Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
Pepsin inhibitor-3 | 0 | DIRECT |
Small-conductance potassium channel | 0 | DIRECT |
Hypothetical protein c14orf129, hspc210 | 0 | DIRECT |
PABC (PABP) domain | 0 | DIRECT |
Restriction endonuclease-like | 0 | DIRECT |
Chitinase insertion domain | 0 | DIRECT |
Ran binding protein zinc finger-like | 0 | DIRECT |
Cu,Zn superoxide dismutase-like | 0 | DIRECT |
Glycolipid transfer protein, GLTP | 0 | DIRECT |
Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
Annexin | 0 | DIRECT |
PEBP-like | 0 | DIRECT |
FAD-binding/transporter-associated domain-like | 0 | DIRECT |
PurM C-terminal domain-like | 0 | DIRECT |
Molybdenum cofactor-binding domain | 0 | DIRECT |
Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
Fibrinogen C-terminal domain-like | 0 | DIRECT |
GYF domain | 0 | DIRECT |
Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | DIRECT |
PEP carboxykinase-like | 0 | DIRECT |
TGS-like | 0 | DIRECT |
Diaminopimelate epimerase-like | 0 | DIRECT |
MOSC N-terminal domain-like | 0 | DIRECT |
FF domain | 0 | DIRECT |
Ribokinase-like | 0 | DIRECT |
CO dehydrogenase ISP C-domain like | 0 | DIRECT |
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | DIRECT |
Outer arm dynein light chain 1 | 0 | DIRECT |
Elafin-like | 0 | DIRECT |
Cadherin-like | 0 | DIRECT |
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
PapD-like | 0.00002149 | DIRECT |
Chromo domain-like | 0.009671 | INHERITED FROM: maternal effect sterile |
SET domain | 0.3456 | INHERITED FROM: maternal effect sterile |
RNA-binding domain, RBD | 1 | INHERITED FROM: sterile F1 |
SCOP term | FDR (all) | Annotation (direct or inherited) |
Tubby C-terminal domain-like | 0 | Direct |
Heme-dependent catalase-like | 0 | Direct |
LysM domain | 0 | Direct |
Cystatin/monellin | 0 | Direct |
CBD9-like | 0 | Direct |
AN1-like Zinc finger | 0 | Direct |
Carbohydrate phosphatase | 0 | Direct |
ADP-ribosylation | 0 | Direct |
SAND domain-like | 0 | Direct |
R3H domain | 0 | Direct |
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | Direct |
Nucleoside diphosphate kinase, NDK | 0 | Direct |
Transducin (alpha subunit), insertion domain | 0 | Direct |
Proton glutamate symport protein | 0 | Direct |
Cation efflux protein cytoplasmic domain-like | 0 | Direct |
3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | Direct |
PurM N-terminal domain-like | 0 | Direct |
Galactose oxidase, central domain | 0 | Direct |
MgtE membrane domain-like | 0 | Direct |
Profilin (actin-binding protein) | 0 | Direct |
CO dehydrogenase molybdoprotein N-domain-like | 0 | Direct |
WGR domain-like | 0 | Direct |
Doublecortin (DC) | 0 | Direct |
eIF4e-like | 0 | Direct |
DNA repair protein MutS, domain III | 0 | Direct |
Oxysterol-binding protein-like | 0 | Direct |
LEM domain | 0 | Direct |
PHM/PNGase F | 0 | Direct |
PK beta-barrel domain-like | 0 | Direct |
Phoshotransferase/anion transport protein | 0 | Direct |
VPS9 domain | 0 | Direct |
Creatinase/prolidase N-terminal domain | 0 | Direct |
Arginase/deacetylase | 0 | Direct |
Complement control module/SCR domain | 0 | Direct |
SWIB/MDM2 domain | 0 | Direct |
SPOC domain-like | 0 | Direct |
FAD-linked oxidases, C-terminal domain | 0 | Direct |
Rap/Ran-GAP | 0 | Direct |
S-adenosylmethionine synthetase | 0 | Direct |
Nucleoporin domain | 0 | Direct |
MFPT repeat-like | 0 | Direct |
GAS2 domain-like | 0 | Direct |
Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
PEP carboxykinase N-terminal domain | 0 | Direct |
Tricorn protease domain 2 | 0 | Direct |
Hormone receptor domain | 0 | Direct |
ARID-like | 0 | Direct |
GAT-like domain | 0 | Direct |
Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
14-3-3 protein | 0 | Direct |
Nop domain | 0 | Direct |
Blood coagulation inhibitor (disintegrin) | 0 | Direct |
Pepsin inhibitor-3 | 0 | Direct |
Small-conductance potassium channel | 0 | Direct |
Hypothetical protein c14orf129, hspc210 | 0 | Direct |
PABC (PABP) domain | 0 | Direct |
Restriction endonuclease-like | 0 | Direct |
Chitinase insertion domain | 0 | Direct |
Ran binding protein zinc finger-like | 0 | Direct |
Cu,Zn superoxide dismutase-like | 0 | Direct |
Glycolipid transfer protein, GLTP | 0 | Direct |
Bacterial exopeptidase dimerisation domain | 0 | Direct |
Annexin | 0 | Direct |
PEBP-like | 0 | Direct |
FAD-binding/transporter-associated domain-like | 0 | Direct |
PurM C-terminal domain-like | 0 | Direct |
Molybdenum cofactor-binding domain | 0 | Direct |
Domain of poly(ADP-ribose) polymerase | 0 | Direct |
Fibrinogen C-terminal domain-like | 0 | Direct |
GYF domain | 0 | Direct |
Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | Direct |
PEP carboxykinase-like | 0 | Direct |
TGS-like | 0 | Direct |
Diaminopimelate epimerase-like | 0 | Direct |
MOSC N-terminal domain-like | 0 | Direct |
FF domain | 0 | Direct |
Ribokinase-like | 0 | Direct |
CO dehydrogenase ISP C-domain like | 0 | Direct |
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | Direct |
Outer arm dynein light chain 1 | 0 | Direct |
Elafin-like | 0 | Direct |
Cadherin-like | 0 | Direct |
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
PapD-like | 0.00002149 | Direct |
Chromo domain-like | 0.009671 | Inherited |
SET domain | 0.3456 | Inherited |
RNA-binding domain, RBD | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this WP term (SDWP level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | DIRECT |
XPF/Rad1/Mus81 nuclease | 0 | DIRECT |
Serum paraoxonase/arylesterase 1, PON1 | 0 | DIRECT |
COMT-like | 0 | DIRECT |
Type II chitinase | 0 | DIRECT |
YihX-like | 0 | DIRECT |
Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
Protein prenyltransferases | 0 | DIRECT |
Paired domain | 0 | DIRECT |
GYF domain | 0 | DIRECT |
AMPK-beta glycogen binding domain-like | 0 | DIRECT |
U-box | 0 | DIRECT |
D-aminoacid oxidase-like | 0 | DIRECT |
Hexokinase | 0 | DIRECT |
Oxysterol-binding protein | 0 | DIRECT |
DPP6 catalytic domain-like | 0 | DIRECT |
Hypothetical protein c14orf129, hspc210 | 0 | DIRECT |
CO dehydrogenase flavoprotein N-terminal domain-like | 0 | DIRECT |
Gamma-glutamyltranspeptidase-like | 0 | DIRECT |
LysM domain | 0 | DIRECT |
Chitinase insertion domain | 0 | DIRECT |
Ran binding protein zinc finger-like | 0 | DIRECT |
NHL repeat | 0 | DIRECT |
Inositol monophosphatase/fructose-1,6-bisphosphatase-like | 0 | DIRECT |
SAM (sterile alpha motif) domain | 0 | DIRECT |
Ribokinase-like | 0 | DIRECT |
Poly(ADP-ribose) polymerase, C-terminal domain | 0 | DIRECT |
GAS2 domain | 0 | DIRECT |
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | DIRECT |
PurM C-terminal domain-like | 0 | DIRECT |
CoA-binding domain | 0 | DIRECT |
NOL1/NOP2/sun | 0 | DIRECT |
PEP carboxykinase N-terminal domain | 0 | DIRECT |
Cytoplasmic domain of inward rectifier potassium channel | 0 | DIRECT |
Profilin (actin-binding protein) | 0 | DIRECT |
LEM domain | 0 | DIRECT |
Choline kinase | 0 | DIRECT |
DEP domain | 0 | DIRECT |
Phosphatidylethanolamine binding protein | 0 | DIRECT |
Histone deacetylase, HDAC | 0 | DIRECT |
RhoGDI-like | 0 | DIRECT |
Vertebrate phospholipase A2 | 0 | DIRECT |
Translation initiation factor eIF4e | 0 | DIRECT |
Tetraspanin | 0 | DIRECT |
Calpain large subunit, catalytic domain (domain II) | 0 | DIRECT |
PUA domain | 0 | DIRECT |
Doublecortin (DC) | 0 | DIRECT |
DNA repair protein MutS, domain III | 0 | DIRECT |
Myotubularin-like phosphatases | 0 | DIRECT |
acyl-CoA oxidase C-terminal domains | 0 | DIRECT |
Rap/Ran-GAP | 0 | DIRECT |
RNA editing terminal uridyl transferase 2, RET2, domain 2 | 0 | DIRECT |
PhzC/PhzF-like | 0 | DIRECT |
Fibrinogen C-terminal domain-like | 0 | DIRECT |
Arylsulfatase | 0 | DIRECT |
SAND domain | 0 | DIRECT |
Nucleoside diphosphate kinase, NDK | 0 | DIRECT |
HD domain | 0 | DIRECT |
WGR domain | 0 | DIRECT |
Glycogenin | 0 | DIRECT |
Glycolipid transfer protein, GLTP | 0 | DIRECT |
Pepsin inhibitor-3 | 0 | DIRECT |
Hydantoinase (dihydropyrimidinase) | 0 | DIRECT |
DEATH domain, DD | 0 | DIRECT |
Annexin | 0 | DIRECT |
Cadherin | 0 | DIRECT |
D-aminoacid oxidase, N-terminal domain | 0 | DIRECT |
Peptidylglycine alpha-hydroxylating monooxygenase, PHM | 0 | DIRECT |
MOSC N-terminal domain-like | 0 | DIRECT |
Nop domain | 0 | DIRECT |
PABC (PABP) domain | 0 | DIRECT |
Inositol polyphosphate 5-phosphatase (IPP5) | 0 | DIRECT |
Bactericidal permeability-increasing protein, BPI | 0 | DIRECT |
Elafin-like | 0 | DIRECT |
14-3-3 protein | 0 | DIRECT |
AN1-like Zinc finger | 0 | DIRECT |
Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
Internalin LRR domain | 0 | DIRECT |
GAPDH-like | 0 | DIRECT |
1,3-glucuronyltransferase | 0 | DIRECT |
Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
Molybdenum cofactor-binding domain | 0 | DIRECT |
ATP-dependent protease Lon (La), catalytic domain | 0 | DIRECT |
Biotin dependent carboxylase carboxyltransferase domain | 0 | DIRECT |
Ras-binding domain, RBD | 0 | DIRECT |
Acyl-CoA thioesterase | 0 | DIRECT |
CO dehydrogenase ISP C-domain like | 0 | DIRECT |
Acireductone dioxygenase | 0 | DIRECT |
LacY-like proton/sugar symporter | 0 | DIRECT |
Pancreatic carboxypeptidase, activation domain | 0 | DIRECT |
Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
S-adenosylmethionine synthetase | 0 | DIRECT |
Transducin (alpha subunit), insertion domain | 0 | DIRECT |
HCDH C-domain-like | 0 | DIRECT |
28-residue LRR | 0 | DIRECT |
SWIB/MDM2 domain | 0 | DIRECT |
MFPT repeat | 0 | DIRECT |
Small-conductance potassium channel | 0 | DIRECT |
Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
Arfaptin, Rac-binding fragment | 0 | DIRECT |
Glycerol kinase | 0 | DIRECT |
PurM N-terminal domain-like | 0 | DIRECT |
L-aminoacid/polyamine oxidase | 0 | DIRECT |
DPP6 N-terminal domain-like | 0 | DIRECT |
Acylamino-acid-releasing enzyme, C-terminal donain | 0 | DIRECT |
Glycerophosphoryl diester phosphodiesterase | 0 | DIRECT |
Methionine aminopeptidase, insert domain | 0 | DIRECT |
FF domain | 0 | DIRECT |
Arginine methyltransferase | 0 | DIRECT |
PEP carboxykinase C-terminal domain | 0 | DIRECT |
First domain of FERM | 0 | DIRECT |
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
Hormone receptor domain | 0 | DIRECT |
ARID domain | 0 | DIRECT |
CO dehydrogenase molybdoprotein N-domain-like | 0 | DIRECT |
Heme-dependent catalases | 0 | DIRECT |
Epoxide hydrolase | 0 | DIRECT |
Inositol polyphosphate kinase (IPK) | 0 | DIRECT |
Cu,Zn superoxide dismutase-like | 0 | DIRECT |
Complement control module/SCR domain | 0 | DIRECT |
Cell cycle control phosphatase, catalytic domain | 0 | DIRECT |
Glutaminase | 0 | DIRECT |
Proton glutamate symport protein | 0 | DIRECT |
Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
acyl-CoA oxidase N-terminal domains | 0 | DIRECT |
MSP-like | 0.00004243 | DIRECT |
Mitochondrial carrier | 0.0005782 | DIRECT |
Histone lysine methyltransferases | 0.4513 | INHERITED FROM: maternal effect sterile |
Canonical RBD | 0.8636 | INHERITED FROM: sterile F1 |
SCOP term | FDR (all) | Annotation (direct or inherited) |
Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | Direct |
XPF/Rad1/Mus81 nuclease | 0 | Direct |
Serum paraoxonase/arylesterase 1, PON1 | 0 | Direct |
COMT-like | 0 | Direct |
Type II chitinase | 0 | Direct |
YihX-like | 0 | Direct |
Domain of poly(ADP-ribose) polymerase | 0 | Direct |
Protein prenyltransferases | 0 | Direct |
Paired domain | 0 | Direct |
GYF domain | 0 | Direct |
AMPK-beta glycogen binding domain-like | 0 | Direct |
U-box | 0 | Direct |
D-aminoacid oxidase-like | 0 | Direct |
Hexokinase | 0 | Direct |
Oxysterol-binding protein | 0 | Direct |
DPP6 catalytic domain-like | 0 | Direct |
Hypothetical protein c14orf129, hspc210 | 0 | Direct |
CO dehydrogenase flavoprotein N-terminal domain-like | 0 | Direct |
Gamma-glutamyltranspeptidase-like | 0 | Direct |
LysM domain | 0 | Direct |
Chitinase insertion domain | 0 | Direct |
Ran binding protein zinc finger-like | 0 | Direct |
NHL repeat | 0 | Direct |
Inositol monophosphatase/fructose-1,6-bisphosphatase-like | 0 | Direct |
SAM (sterile alpha motif) domain | 0 | Direct |
Ribokinase-like | 0 | Direct |
Poly(ADP-ribose) polymerase, C-terminal domain | 0 | Direct |
GAS2 domain | 0 | Direct |
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | Direct |
PurM C-terminal domain-like | 0 | Direct |
CoA-binding domain | 0 | Direct |
NOL1/NOP2/sun | 0 | Direct |
PEP carboxykinase N-terminal domain | 0 | Direct |
Cytoplasmic domain of inward rectifier potassium channel | 0 | Direct |
Profilin (actin-binding protein) | 0 | Direct |
LEM domain | 0 | Direct |
Choline kinase | 0 | Direct |
DEP domain | 0 | Direct |
Phosphatidylethanolamine binding protein | 0 | Direct |
Histone deacetylase, HDAC | 0 | Direct |
RhoGDI-like | 0 | Direct |
Vertebrate phospholipase A2 | 0 | Direct |
Translation initiation factor eIF4e | 0 | Direct |
Tetraspanin | 0 | Direct |
Calpain large subunit, catalytic domain (domain II) | 0 | Direct |
PUA domain | 0 | Direct |
Doublecortin (DC) | 0 | Direct |
DNA repair protein MutS, domain III | 0 | Direct |
Myotubularin-like phosphatases | 0 | Direct |
acyl-CoA oxidase C-terminal domains | 0 | Direct |
Rap/Ran-GAP | 0 | Direct |
RNA editing terminal uridyl transferase 2, RET2, domain 2 | 0 | Direct |
PhzC/PhzF-like | 0 | Direct |
Fibrinogen C-terminal domain-like | 0 | Direct |
Arylsulfatase | 0 | Direct |
SAND domain | 0 | Direct |
Nucleoside diphosphate kinase, NDK | 0 | Direct |
HD domain | 0 | Direct |
WGR domain | 0 | Direct |
Glycogenin | 0 | Direct |
Glycolipid transfer protein, GLTP | 0 | Direct |
Pepsin inhibitor-3 | 0 | Direct |
Hydantoinase (dihydropyrimidinase) | 0 | Direct |
DEATH domain, DD | 0 | Direct |
Annexin | 0 | Direct |
Cadherin | 0 | Direct |
D-aminoacid oxidase, N-terminal domain | 0 | Direct |
Peptidylglycine alpha-hydroxylating monooxygenase, PHM | 0 | Direct |
MOSC N-terminal domain-like | 0 | Direct |
Nop domain | 0 | Direct |
PABC (PABP) domain | 0 | Direct |
Inositol polyphosphate 5-phosphatase (IPP5) | 0 | Direct |
Bactericidal permeability-increasing protein, BPI | 0 | Direct |
Elafin-like | 0 | Direct |
14-3-3 protein | 0 | Direct |
AN1-like Zinc finger | 0 | Direct |
Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
Internalin LRR domain | 0 | Direct |
GAPDH-like | 0 | Direct |
1,3-glucuronyltransferase | 0 | Direct |
Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
Molybdenum cofactor-binding domain | 0 | Direct |
ATP-dependent protease Lon (La), catalytic domain | 0 | Direct |
Biotin dependent carboxylase carboxyltransferase domain | 0 | Direct |
Ras-binding domain, RBD | 0 | Direct |
Acyl-CoA thioesterase | 0 | Direct |
CO dehydrogenase ISP C-domain like | 0 | Direct |
Acireductone dioxygenase | 0 | Direct |
LacY-like proton/sugar symporter | 0 | Direct |
Pancreatic carboxypeptidase, activation domain | 0 | Direct |
Blood coagulation inhibitor (disintegrin) | 0 | Direct |
S-adenosylmethionine synthetase | 0 | Direct |
Transducin (alpha subunit), insertion domain | 0 | Direct |
HCDH C-domain-like | 0 | Direct |
28-residue LRR | 0 | Direct |
SWIB/MDM2 domain | 0 | Direct |
MFPT repeat | 0 | Direct |
Small-conductance potassium channel | 0 | Direct |
Cation efflux protein cytoplasmic domain-like | 0 | Direct |
Arfaptin, Rac-binding fragment | 0 | Direct |
Glycerol kinase | 0 | Direct |
PurM N-terminal domain-like | 0 | Direct |
L-aminoacid/polyamine oxidase | 0 | Direct |
DPP6 N-terminal domain-like | 0 | Direct |
Acylamino-acid-releasing enzyme, C-terminal donain | 0 | Direct |
Glycerophosphoryl diester phosphodiesterase | 0 | Direct |
Methionine aminopeptidase, insert domain | 0 | Direct |
FF domain | 0 | Direct |
Arginine methyltransferase | 0 | Direct |
PEP carboxykinase C-terminal domain | 0 | Direct |
First domain of FERM | 0 | Direct |
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
Hormone receptor domain | 0 | Direct |
ARID domain | 0 | Direct |
CO dehydrogenase molybdoprotein N-domain-like | 0 | Direct |
Heme-dependent catalases | 0 | Direct |
Epoxide hydrolase | 0 | Direct |
Inositol polyphosphate kinase (IPK) | 0 | Direct |
Cu,Zn superoxide dismutase-like | 0 | Direct |
Complement control module/SCR domain | 0 | Direct |
Cell cycle control phosphatase, catalytic domain | 0 | Direct |
Glutaminase | 0 | Direct |
Proton glutamate symport protein | 0 | Direct |
Bacterial exopeptidase dimerisation domain | 0 | Direct |
acyl-CoA oxidase N-terminal domains | 0 | Direct |
MSP-like | 0.00004243 | Direct |
Mitochondrial carrier | 0.0005782 | Direct |
Histone lysine methyltransferases | 0.4513 | Inherited |
Canonical RBD | 0.8636 | Inherited |
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A presence/absence matrix is generated using protein domain
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this WP term (SPWP level: Least Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
Nop domain | 0 | DIRECT |
Cadherin-like | 0 | DIRECT |
AN1-like Zinc finger | 0 | DIRECT |
Hormone receptor domain | 0 | DIRECT |
PEP carboxykinase N-terminal domain | 0 | DIRECT |
FF domain | 0 | DIRECT |
Nucleoside diphosphate kinase, NDK | 0 | DIRECT |
Tricorn protease domain 2 | 0 | DIRECT |
Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
Ribokinase-like | 0 | DIRECT |
ADP-ribosylation | 0 | DIRECT |
Galactose oxidase, central domain | 0 | DIRECT |
MgtE membrane domain-like | 0 | DIRECT |
Tubby C-terminal domain-like | 0 | DIRECT |
Restriction endonuclease-like | 0 | DIRECT |
SWIB/MDM2 domain | 0 | DIRECT |
Cu,Zn superoxide dismutase-like | 0 | DIRECT |
Chitinase insertion domain | 0 | DIRECT |
Oxysterol-binding protein-like | 0 | DIRECT |
MOSC N-terminal domain-like | 0 | DIRECT |
PHM/PNGase F | 0 | DIRECT |
PABC (PABP) domain | 0 | DIRECT |
Phoshotransferase/anion transport protein | 0 | DIRECT |
SAND domain-like | 0 | DIRECT |
Ran binding protein zinc finger-like | 0 | DIRECT |
PurM N-terminal domain-like | 0 | DIRECT |
LysM domain | 0 | DIRECT |
Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
DNA repair protein MutS, domain III | 0 | DIRECT |
MFPT repeat-like | 0 | DIRECT |
Pepsin inhibitor-3 | 0 | DIRECT |
PK beta-barrel domain-like | 0 | DIRECT |
Cystatin/monellin | 0 | DIRECT |
Molybdenum cofactor-binding domain | 0 | DIRECT |
GAT-like domain | 0 | DIRECT |
R3H domain | 0 | DIRECT |
eIF4e-like | 0 | DIRECT |
S-adenosylmethionine synthetase | 0 | DIRECT |
3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | DIRECT |
Doublecortin (DC) | 0 | DIRECT |
Profilin (actin-binding protein) | 0 | DIRECT |
Rap/Ran-GAP | 0 | DIRECT |
CBD9-like | 0 | DIRECT |
GYF domain | 0 | DIRECT |
Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
Diaminopimelate epimerase-like | 0 | DIRECT |
Transducin (alpha subunit), insertion domain | 0 | DIRECT |
Nucleoporin domain | 0 | DIRECT |
Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
PEP carboxykinase-like | 0 | DIRECT |
Hypothetical protein c14orf129, hspc210 | 0 | DIRECT |
CO dehydrogenase molybdoprotein N-domain-like | 0 | DIRECT |
PurM C-terminal domain-like | 0 | DIRECT |
SPOC domain-like | 0 | DIRECT |
Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
ARID-like | 0 | DIRECT |
VPS9 domain | 0 | DIRECT |
LEM domain | 0 | DIRECT |
Proton glutamate symport protein | 0 | DIRECT |
Complement control module/SCR domain | 0 | DIRECT |
Fibrinogen C-terminal domain-like | 0 | DIRECT |
Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
FAD-binding/transporter-associated domain-like | 0 | DIRECT |
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | DIRECT |
Small-conductance potassium channel | 0 | DIRECT |
Creatinase/prolidase N-terminal domain | 0 | DIRECT |
Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
GAS2 domain-like | 0 | DIRECT |
Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | DIRECT |
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | DIRECT |
PEBP-like | 0 | DIRECT |
Outer arm dynein light chain 1 | 0 | DIRECT |
Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
Elafin-like | 0 | DIRECT |
WGR domain-like | 0 | DIRECT |
Arginase/deacetylase | 0 | DIRECT |
CO dehydrogenase ISP C-domain like | 0 | DIRECT |
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
TGS-like | 0 | DIRECT |
Annexin | 0 | DIRECT |
14-3-3 protein | 0 | DIRECT |
Carbohydrate phosphatase | 0 | DIRECT |
Glycolipid transfer protein, GLTP | 0 | DIRECT |
Heme-dependent catalase-like | 0 | DIRECT |
FAD-linked oxidases, C-terminal domain | 0 | DIRECT |
PapD-like | 0.00001757 | DIRECT |
Mitochondrial carrier | 0.0008548 | DIRECT |
Chromo domain-like | 0.008322 | INHERITED FROM: maternal effect sterile |
SET domain | 0.3257 | INHERITED FROM: maternal effect sterile |
RNA-binding domain, RBD | 0.9933 | INHERITED FROM: sterile F1 |
Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
Nop domain | 0 | Direct |
Cadherin-like | 0 | Direct |
AN1-like Zinc finger | 0 | Direct |
Hormone receptor domain | 0 | Direct |
PEP carboxykinase N-terminal domain | 0 | Direct |
FF domain | 0 | Direct |
Nucleoside diphosphate kinase, NDK | 0 | Direct |
Tricorn protease domain 2 | 0 | Direct |
Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
Ribokinase-like | 0 | Direct |
ADP-ribosylation | 0 | Direct |
Galactose oxidase, central domain | 0 | Direct |
MgtE membrane domain-like | 0 | Direct |
Tubby C-terminal domain-like | 0 | Direct |
Restriction endonuclease-like | 0 | Direct |
SWIB/MDM2 domain | 0 | Direct |
Cu,Zn superoxide dismutase-like | 0 | Direct |
Chitinase insertion domain | 0 | Direct |
Oxysterol-binding protein-like | 0 | Direct |
MOSC N-terminal domain-like | 0 | Direct |
PHM/PNGase F | 0 | Direct |
PABC (PABP) domain | 0 | Direct |
Phoshotransferase/anion transport protein | 0 | Direct |
SAND domain-like | 0 | Direct |
Ran binding protein zinc finger-like | 0 | Direct |
PurM N-terminal domain-like | 0 | Direct |
LysM domain | 0 | Direct |
Domain of poly(ADP-ribose) polymerase | 0 | Direct |
DNA repair protein MutS, domain III | 0 | Direct |
MFPT repeat-like | 0 | Direct |
Pepsin inhibitor-3 | 0 | Direct |
PK beta-barrel domain-like | 0 | Direct |
Cystatin/monellin | 0 | Direct |
Molybdenum cofactor-binding domain | 0 | Direct |
GAT-like domain | 0 | Direct |
R3H domain | 0 | Direct |
eIF4e-like | 0 | Direct |
S-adenosylmethionine synthetase | 0 | Direct |
3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | Direct |
Doublecortin (DC) | 0 | Direct |
Profilin (actin-binding protein) | 0 | Direct |
Rap/Ran-GAP | 0 | Direct |
CBD9-like | 0 | Direct |
GYF domain | 0 | Direct |
Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
Diaminopimelate epimerase-like | 0 | Direct |
Transducin (alpha subunit), insertion domain | 0 | Direct |
Nucleoporin domain | 0 | Direct |
Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
PEP carboxykinase-like | 0 | Direct |
Hypothetical protein c14orf129, hspc210 | 0 | Direct |
CO dehydrogenase molybdoprotein N-domain-like | 0 | Direct |
PurM C-terminal domain-like | 0 | Direct |
SPOC domain-like | 0 | Direct |
Blood coagulation inhibitor (disintegrin) | 0 | Direct |
ARID-like | 0 | Direct |
VPS9 domain | 0 | Direct |
LEM domain | 0 | Direct |
Proton glutamate symport protein | 0 | Direct |
Complement control module/SCR domain | 0 | Direct |
Fibrinogen C-terminal domain-like | 0 | Direct |
Cation efflux protein cytoplasmic domain-like | 0 | Direct |
FAD-binding/transporter-associated domain-like | 0 | Direct |
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | Direct |
Small-conductance potassium channel | 0 | Direct |
Creatinase/prolidase N-terminal domain | 0 | Direct |
Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
GAS2 domain-like | 0 | Direct |
Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | Direct |
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | Direct |
PEBP-like | 0 | Direct |
Outer arm dynein light chain 1 | 0 | Direct |
Bacterial exopeptidase dimerisation domain | 0 | Direct |
Elafin-like | 0 | Direct |
WGR domain-like | 0 | Direct |
Arginase/deacetylase | 0 | Direct |
CO dehydrogenase ISP C-domain like | 0 | Direct |
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
TGS-like | 0 | Direct |
Annexin | 0 | Direct |
14-3-3 protein | 0 | Direct |
Carbohydrate phosphatase | 0 | Direct |
Glycolipid transfer protein, GLTP | 0 | Direct |
Heme-dependent catalase-like | 0 | Direct |
FAD-linked oxidases, C-terminal domain | 0 | Direct |
PapD-like | 0.00001757 | Direct |
Mitochondrial carrier | 0.0008548 | Direct |
Chromo domain-like | 0.008322 | Inherited |
SET domain | 0.3257 | Inherited |
RNA-binding domain, RBD | 0.9933 | Inherited |
(show details)
Supra-domains annotated to this WP term (SPWP level: Least Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
81324,81296 81324 - Voltage-gated potassium channels 81296 - E set domains | 0 | DIRECT |
48179,48179 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
56176,55103 56176 - FAD-binding/transporter-associated domain-like 55103 - FAD-linked oxidases, C-terminal domain | 0 | DIRECT |
161093,161093 161093 - MgtE membrane domain-like 161093 - MgtE membrane domain-like | 0 | DIRECT |
48334,52540 48334 - DNA repair protein MutS, domain III 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
141739,141739 141739 - MFPT repeat-like 141739 - MFPT repeat-like | 0 | DIRECT |
54495,46934 54495 - UBC-like 46934 - UBA-like | 0 | DIRECT |
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
56112,48371 56112 - Protein kinase-like (PK-like) 48371 - ARM repeat | 0 | DIRECT |
52540,81271 52540 - P-loop containing nucleoside triphosphate hydrolases 81271 - TGS-like | 0 | DIRECT |
57903,82199 57903 - FYVE/PHD zinc finger 82199 - SET domain | 0 | DIRECT |
47473,51695 47473 - EF-hand 51695 - PLC-like phosphodiesterases | 0 | DIRECT |
47741,56176 47741 - CO dehydrogenase ISP C-domain like 56176 - FAD-binding/transporter-associated domain-like | 0 | DIRECT |
55486,57552 55486 - Metalloproteases ("zincins"), catalytic domain 57552 - Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
49742,49742 49742 - PHM/PNGase F 49742 - PHM/PNGase F | 0 | DIRECT |
55973,55973 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase | 0 | DIRECT |
68923,53795 68923 - PEP carboxykinase N-terminal domain 53795 - PEP carboxykinase-like | 0 | DIRECT |
57196,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
54001,49758 54001 - Cysteine proteinases 49758 - Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain | 0 | DIRECT |
57863,48403 57863 - ArfGap/RecO-like zinc finger 48403 - Ankyrin repeat | 0 | DIRECT |
51971,54373 51971 - Nucleotide-binding domain 54373 - FAD-linked reductases, C-terminal domain | 0 | DIRECT |
47769,47769 47769 - SAM/Pointed domain 47769 - SAM/Pointed domain | 0 | DIRECT |
81383,52047 81383 - F-box domain 52047 - RNI-like | 0 | DIRECT |
81698,81698 81698 - FF domain 81698 - FF domain | 0 | DIRECT |
51338,51556 51338 - Composite domain of metallo-dependent hydrolases 51556 - Metallo-dependent hydrolases | 0 | DIRECT |
55486,50923 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain | 0 | DIRECT |
51445,54556 51445 - (Trans)glycosidases 54556 - Chitinase insertion domain | 0 | DIRECT |
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
48425,50729 48425 - Sec7 domain 50729 - PH domain-like | 0 | DIRECT |
49313,49313 49313 - Cadherin-like 49313 - Cadherin-like | 0 | DIRECT |
46785,46785 46785 - "Winged helix" DNA-binding domain 46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
55326,56042 55326 - PurM N-terminal domain-like 56042 - PurM C-terminal domain-like | 0 | DIRECT |
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat | 0 | DIRECT |
47203,47203 47203 - Acyl-CoA dehydrogenase C-terminal domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
54897,53187 54897 - Protease propeptides/inhibitors 53187 - Zn-dependent exopeptidases | 0 | DIRECT |
47587,56399 47587 - Domain of poly(ADP-ribose) polymerase 56399 - ADP-ribosylation | 0 | DIRECT |
54534,54534 54534 - FKBP-like 54534 - FKBP-like | 0 | DIRECT |
144232,82199 144232 - HIT/MYND zinc finger-like 82199 - SET domain | 0 | DIRECT |
48403,52151 48403 - Ankyrin repeat 52151 - FabD/lysophospholipase-like | 0 | DIRECT |
81324,53850 81324 - Voltage-gated potassium channels 53850 - Periplasmic binding protein-like II | 0 | DIRECT |
48464,89009 48464 - ENTH/VHS domain 89009 - GAT-like domain | 0 | DIRECT |
53187,55031 53187 - Zn-dependent exopeptidases 55031 - Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
47473,103506 47473 - EF-hand 103506 - Mitochondrial carrier | 0 | DIRECT |
56601,48403 56601 - beta-lactamase/transpeptidase-like 48403 - Ankyrin repeat | 0 | DIRECT |
54665,56003 54665 - CO dehydrogenase molybdoprotein N-domain-like 56003 - Molybdenum cofactor-binding domain | 0 | DIRECT |
161111,160240 161111 - Cation efflux protein transmembrane domain-like 160240 - Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
141673,50800 141673 - MOSC N-terminal domain-like 50800 - PK beta-barrel domain-like | 0 | DIRECT |
54292,47741 54292 - 2Fe-2S ferredoxin-like 47741 - CO dehydrogenase ISP C-domain like | 0 | DIRECT |
57903,51197 57903 - FYVE/PHD zinc finger 51197 - Clavaminate synthase-like | 0 | DIRECT |
55920,46785 55920 - Creatinase/aminopeptidase 46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
81324,81327 81324 - Voltage-gated potassium channels 81327 - Small-conductance potassium channel | 0 | DIRECT |
50978,50998 50978 - WD40 repeat-like 50998 - Quinoprotein alcohol dehydrogenase-like | 0 | DIRECT |
57850,117839 57850 - RING/U-box 117839 - WWE domain | 0 | DIRECT |
55394,55394 55394 - Bactericidal permeability-increasing protein, BPI 55394 - Bactericidal permeability-increasing protein, BPI | 0 | DIRECT |
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
81324,81296 81324 - Voltage-gated potassium channels 81296 - E set domains | 0 | Direct |
48179,48179 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
56176,55103 56176 - FAD-binding/transporter-associated domain-like 55103 - FAD-linked oxidases, C-terminal domain | 0 | Direct |
161093,161093 161093 - MgtE membrane domain-like 161093 - MgtE membrane domain-like | 0 | Direct |
48334,52540 48334 - DNA repair protein MutS, domain III 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
141739,141739 141739 - MFPT repeat-like 141739 - MFPT repeat-like | 0 | Direct |
54495,46934 54495 - UBC-like 46934 - UBA-like | 0 | Direct |
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | Direct |
56112,48371 56112 - Protein kinase-like (PK-like) 48371 - ARM repeat | 0 | Direct |
52540,81271 52540 - P-loop containing nucleoside triphosphate hydrolases 81271 - TGS-like | 0 | Direct |
57903,82199 57903 - FYVE/PHD zinc finger 82199 - SET domain | 0 | Direct |
47473,51695 47473 - EF-hand 51695 - PLC-like phosphodiesterases | 0 | Direct |
47741,56176 47741 - CO dehydrogenase ISP C-domain like 56176 - FAD-binding/transporter-associated domain-like | 0 | Direct |
55486,57552 55486 - Metalloproteases ("zincins"), catalytic domain 57552 - Blood coagulation inhibitor (disintegrin) | 0 | Direct |
49742,49742 49742 - PHM/PNGase F 49742 - PHM/PNGase F | 0 | Direct |
55973,55973 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase | 0 | Direct |
68923,53795 68923 - PEP carboxykinase N-terminal domain 53795 - PEP carboxykinase-like | 0 | Direct |
57196,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
54001,49758 54001 - Cysteine proteinases 49758 - Calpain large subunit, middle domain (domain III) | 0 | Direct |
57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain | 0 | Direct |
57863,48403 57863 - ArfGap/RecO-like zinc finger 48403 - Ankyrin repeat | 0 | Direct |
51971,54373 51971 - Nucleotide-binding domain 54373 - FAD-linked reductases, C-terminal domain | 0 | Direct |
47769,47769 47769 - SAM/Pointed domain 47769 - SAM/Pointed domain | 0 | Direct |
81383,52047 81383 - F-box domain 52047 - RNI-like | 0 | Direct |
81698,81698 81698 - FF domain 81698 - FF domain | 0 | Direct |
51338,51556 51338 - Composite domain of metallo-dependent hydrolases 51556 - Metallo-dependent hydrolases | 0 | Direct |
55486,50923 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain | 0 | Direct |
51445,54556 51445 - (Trans)glycosidases 54556 - Chitinase insertion domain | 0 | Direct |
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
48425,50729 48425 - Sec7 domain 50729 - PH domain-like | 0 | Direct |
49313,49313 49313 - Cadherin-like 49313 - Cadherin-like | 0 | Direct |
46785,46785 46785 - "Winged helix" DNA-binding domain 46785 - "Winged helix" DNA-binding domain | 0 | Direct |
55326,56042 55326 - PurM N-terminal domain-like 56042 - PurM C-terminal domain-like | 0 | Direct |
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat | 0 | Direct |
47203,47203 47203 - Acyl-CoA dehydrogenase C-terminal domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
54897,53187 54897 - Protease propeptides/inhibitors 53187 - Zn-dependent exopeptidases | 0 | Direct |
47587,56399 47587 - Domain of poly(ADP-ribose) polymerase 56399 - ADP-ribosylation | 0 | Direct |
54534,54534 54534 - FKBP-like 54534 - FKBP-like | 0 | Direct |
144232,82199 144232 - HIT/MYND zinc finger-like 82199 - SET domain | 0 | Direct |
48403,52151 48403 - Ankyrin repeat 52151 - FabD/lysophospholipase-like | 0 | Direct |
81324,53850 81324 - Voltage-gated potassium channels 53850 - Periplasmic binding protein-like II | 0 | Direct |
48464,89009 48464 - ENTH/VHS domain 89009 - GAT-like domain | 0 | Direct |
53187,55031 53187 - Zn-dependent exopeptidases 55031 - Bacterial exopeptidase dimerisation domain | 0 | Direct |
47473,103506 47473 - EF-hand 103506 - Mitochondrial carrier | 0 | Direct |
56601,48403 56601 - beta-lactamase/transpeptidase-like 48403 - Ankyrin repeat | 0 | Direct |
54665,56003 54665 - CO dehydrogenase molybdoprotein N-domain-like 56003 - Molybdenum cofactor-binding domain | 0 | Direct |
161111,160240 161111 - Cation efflux protein transmembrane domain-like 160240 - Cation efflux protein cytoplasmic domain-like | 0 | Direct |
141673,50800 141673 - MOSC N-terminal domain-like 50800 - PK beta-barrel domain-like | 0 | Direct |
54292,47741 54292 - 2Fe-2S ferredoxin-like 47741 - CO dehydrogenase ISP C-domain like | 0 | Direct |
57903,51197 57903 - FYVE/PHD zinc finger 51197 - Clavaminate synthase-like | 0 | Direct |
55920,46785 55920 - Creatinase/aminopeptidase 46785 - "Winged helix" DNA-binding domain | 0 | Direct |
81324,81327 81324 - Voltage-gated potassium channels 81327 - Small-conductance potassium channel | 0 | Direct |
50978,50998 50978 - WD40 repeat-like 50998 - Quinoprotein alcohol dehydrogenase-like | 0 | Direct |
57850,117839 57850 - RING/U-box 117839 - WWE domain | 0 | Direct |
55394,55394 55394 - Bactericidal permeability-increasing protein, BPI 55394 - Bactericidal permeability-increasing protein, BPI | 0 | Direct |
(show details)
Supra-domains annotated to this WP term (SPWP level: Least Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
56645,47203,47203 56645 - Acyl-CoA dehydrogenase NM domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
46938,52087,101576 46938 - CRAL/TRIO N-terminal domain 52087 - CRAL/TRIO domain 101576 - Supernatant protein factor (SPF), C-terminal domain | 0 | DIRECT |
54292,47741,56176 54292 - 2Fe-2S ferredoxin-like 47741 - CO dehydrogenase ISP C-domain like 56176 - FAD-binding/transporter-associated domain-like | 0 | DIRECT |
50729,47473,51695 50729 - PH domain-like 47473 - EF-hand 51695 - PLC-like phosphodiesterases | 0 | DIRECT |
56436,49854,49854 56436 - C-type lectin-like 49854 - Spermadhesin, CUB domain 49854 - Spermadhesin, CUB domain | 0 | DIRECT |
47090,55486,50923 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain | 0 | DIRECT |
49313,49313,49313 49313 - Cadherin-like 49313 - Cadherin-like 49313 - Cadherin-like | 0 | DIRECT |
55973,55973,55973 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase | 0 | DIRECT |
57535,57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain | 0 | DIRECT |
50044,50044,50044 50044 - SH3-domain 50044 - SH3-domain 50044 - SH3-domain | 0 | DIRECT |
57567,57567,57567 57567 - Serine protease inhibitors 57567 - Serine protease inhibitors 57567 - Serine protease inhibitors | 0 | DIRECT |
51735,48179,48179 51735 - NAD(P)-binding Rossmann-fold domains 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
48726,49265,48726 48726 - Immunoglobulin 49265 - Fibronectin type III 48726 - Immunoglobulin | 0 | DIRECT |
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
56645,47203,47203 56645 - Acyl-CoA dehydrogenase NM domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
46938,52087,101576 46938 - CRAL/TRIO N-terminal domain 52087 - CRAL/TRIO domain 101576 - Supernatant protein factor (SPF), C-terminal domain | 0 | Direct |
54292,47741,56176 54292 - 2Fe-2S ferredoxin-like 47741 - CO dehydrogenase ISP C-domain like 56176 - FAD-binding/transporter-associated domain-like | 0 | Direct |
50729,47473,51695 50729 - PH domain-like 47473 - EF-hand 51695 - PLC-like phosphodiesterases | 0 | Direct |
56436,49854,49854 56436 - C-type lectin-like 49854 - Spermadhesin, CUB domain 49854 - Spermadhesin, CUB domain | 0 | Direct |
47090,55486,50923 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain | 0 | Direct |
49313,49313,49313 49313 - Cadherin-like 49313 - Cadherin-like 49313 - Cadherin-like | 0 | Direct |
55973,55973,55973 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase | 0 | Direct |
57535,57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain | 0 | Direct |
50044,50044,50044 50044 - SH3-domain 50044 - SH3-domain 50044 - SH3-domain | 0 | Direct |
57567,57567,57567 57567 - Serine protease inhibitors 57567 - Serine protease inhibitors 57567 - Serine protease inhibitors | 0 | Direct |
51735,48179,48179 51735 - NAD(P)-binding Rossmann-fold domains 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
48726,49265,48726 48726 - Immunoglobulin 49265 - Fibronectin type III 48726 - Immunoglobulin | 0 | Direct |
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | Direct |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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