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Worm Phenotype (WP): metabolic pathway variant

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Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   Variant [WBPhenotype:0000886] <2>
+ + + + 4:   physiology variant [WBPhenotype:0000519] <14>(510|587) (510|248|68)
+ + + 3:   organism physiology variant [WBPhenotype:0000576] <9>(369|431) (372|193|56)
+ + 2:   organism homeostasis metabolism variant [WBPhenotype:0000577] <16>(361|421) (363|190|55)
+ 1:   organism metabolism processing variant [WBPhenotype:0000027] <25>(178|190) (182|87|26)
0:   metabolic pathway variant [WBPhenotype:0000463] <8>(39|32) (39|15|9)
- 1:   protein metabolism variant [WBPhenotype:0001644] <9>(30|26) (30|15|8)
- 1:   DNA metabolism variant [WBPhenotype:0000732] <7>(1|0) (1|0|0)
- 1:   biosynthesis variant [WBPhenotype:0001696] <6>(1|1) (1|0|0)
- 1:   RNA metabolism variant [WBPhenotype:0001827] <5>(4|2) (4|0|0)
- 1:   amino acid metabolism variant [WBPhenotype:0002255](0|0) (0|0|0)
- 1:   metabolite content decreased [WBPhenotype:0002270](1|1) (1|0|0)
- 1:   metabolite content increased [WBPhenotype:0002357](0|0) (0|0|0)
- 1:   second messenger mediated signaling variant [WBPhenotype:0001841](3|2) (3|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Heme-dependent catalase-like0Direct
Arginase/deacetylase0.0000000001815Direct
Lipovitellin-phosvitin complex, superhelical domain0.0000004686Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0.0000004686Direct
Protein kinase-like (PK-like)0.00005289Direct
ADC-like0.00008175Direct
Cdc48 domain 2-like0.00008175Direct
Integrin domains0.00008175Direct
Calpain large subunit, middle domain (domain III)0.0001799Direct
DHS-like NAD/FAD-binding domain0.0001799Direct
Translational machinery components0.0008494Direct
Zn-binding ribosomal proteins0.0008494Direct
L30e-like0.0009659Direct
SET domain0.001428Inherited
RNA-binding domain, RBD0.00336Inherited
PH domain-like0.005975Inherited
GroEL-intermediate domain like0.007024Inherited
GroEL equatorial domain-like0.007024Inherited
DNA/RNA polymerases0.01047Inherited
Spectrin repeat0.01047Inherited
GroEL apical domain-like0.01377Inherited
SH3-domain0.01422Inherited
F1F0 ATP synthase subunit C0.01477Inherited
Voltage-gated potassium channels0.02294Inherited
Translation proteins0.03206Inherited
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0.03448Inherited
Quinoprotein alcohol dehydrogenase-like0.03895Inherited
Nucleic acid-binding proteins0.1054Inherited
Immunoglobulin0.1266Inherited
Clavaminate synthase-like0.1717Inherited
Cyclin-like0.2547Inherited
Sm-like ribonucleoproteins0.3098Inherited
Transducin (alpha subunit), insertion domain0.3684Inherited
Nucleotide cyclase0.4172Inherited
FYVE/PHD zinc finger0.4305Inherited
Periplasmic binding protein-like I0.4749Inherited
Cytochrome P4500.6074Inherited
Chromo domain-like0.6827Inherited
Homeodomain-like1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Sir2 family of transcriptional regulators0Direct
Heme-dependent catalases0Direct
Histone deacetylase, HDAC0Direct
Integrin domains0Direct
Lipovitellin-phosvitin complex, superhelical domain0.000001116Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0.000001116Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0000541Direct
Cdc48 domain 2-like0.000133Direct
Cdc48 N-terminal domain-like0.000133Direct
Calpain large subunit, middle domain (domain III)0.0001696Direct
Proteasome subunits0.0009902Direct
Histone lysine methyltransferases0.0009902Direct
Calpain large subunit, catalytic domain (domain II)0.001489Inherited
Group II chaperonin (CCT, TRIC), intermediate domain0.00358Inherited
Spectrin repeat0.003644Inherited
Pleckstrin-homology domain (PH domain)0.003697Inherited
Protein kinases, catalytic subunit0.004688Inherited
Canonical RBD0.005529Inherited
I set domains0.008424Inherited
F1F0 ATP synthase subunit C0.01384Inherited
Group II chaperonin (CCT, TRIC), ATPase domain0.02115Inherited
Elongation factors0.02382Inherited
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0.0329Inherited
G proteins0.03688Inherited
Group II chaperonin (CCT, TRIC), apical domain0.03809Inherited
LIM domain0.06125Inherited
Voltage-gated potassium channels0.07839Inherited
Cold shock DNA-binding domain-like0.2575Inherited
Transducin (alpha subunit), insertion domain0.3708Inherited
PHD domain0.4094Inherited
Adenylyl and guanylyl cyclase catalytic domain0.5437Inherited
Cytochrome P4500.7798Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Heme-dependent catalase-like0Direct
Arginase/deacetylase0.0000000001437Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0.0000003774Direct
Lipovitellin-phosvitin complex, superhelical domain0.0000003774Direct
Protein kinase-like (PK-like)0.00004328Direct
Cdc48 domain 2-like0.00006692Direct
Integrin domains0.00006692Direct
ADC-like0.00006692Direct
DHS-like NAD/FAD-binding domain0.0001477Direct
Calpain large subunit, middle domain (domain III)0.0001477Direct
Translational machinery components0.0007066Direct
Zn-binding ribosomal proteins0.0007066Direct
L30e-like0.0008038Direct
SET domain0.001193Inherited
RNA-binding domain, RBD0.00284Inherited
PH domain-like0.005087Inherited
GroEL equatorial domain-like0.005993Inherited
GroEL-intermediate domain like0.005993Inherited
DNA/RNA polymerases0.009014Inherited
Spectrin repeat0.009014Inherited
GroEL apical domain-like0.01192Inherited
SH3-domain0.0123Inherited
F1F0 ATP synthase subunit C0.01279Inherited
Voltage-gated potassium channels0.02002Inherited
Translation proteins0.02819Inherited
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0.03034Inherited
Quinoprotein alcohol dehydrogenase-like0.03433Inherited
Nucleic acid-binding proteins0.09533Inherited
Immunoglobulin0.115Inherited
Clavaminate synthase-like0.1574Inherited
Cyclin-like0.2368Inherited
Sm-like ribonucleoproteins0.2905Inherited
Transducin (alpha subunit), insertion domain0.348Inherited
Nucleotide cyclase0.3965Inherited
FYVE/PHD zinc finger0.4097Inherited
Periplasmic binding protein-like I0.4536Inherited
Cytochrome P4500.5855Inherited
Chromo domain-like0.6614Inherited
Homeodomain-like1Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0.0000003774Direct
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.0000003774Direct
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0.0001477Direct
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0.003327Inherited
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.005993Inherited
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.005993Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.009014Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.01118Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.01279Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.02097Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.08633Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.1141Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.348Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48371,48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.0000003774Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.005993Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.01279Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.01279Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.05271Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.09115Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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