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Worm Phenotype (WP): metabolic pathway variant

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Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   Variant [WBPhenotype:0000886] <4>
+ + + + 4:   physiology variant [WBPhenotype:0000519] <7>(489|563) (489|241|65)
+ + + 3:   organism physiology variant [WBPhenotype:0000576] <10>(357|420) (358|193|57)
+ + 2:   organism homeostasis metabolism variant [WBPhenotype:0000577] <17>(347|410) (350|191|56)
+ 1:   organism metabolism processing variant [WBPhenotype:0000027] <25>(171|182) (176|81|24)
0:   metabolic pathway variant [WBPhenotype:0000463] <8>(35|28) (35|16|8)
- 1:   protein metabolism variant [WBPhenotype:0001644] <10>(28|24) (28|15|8)
- 1:   DNA metabolism variant [WBPhenotype:0000732] <7>(1|0) (1|0|0)
- 1:   RNA metabolism variant [WBPhenotype:0001827] <6>(1|1) (1|1|0)
- 1:   biosynthesis variant [WBPhenotype:0001696] <5>(0|0) (0|0|0)
- 1:   amino acid metabolism variant [WBPhenotype:0002255](0|0) (0|0|0)
- 1:   metabolite content decreased [WBPhenotype:0002270](1|1) (1|0|0)
- 1:   metabolite content increased [WBPhenotype:0002357](0|0) (0|0|0)
- 1:   second messenger mediated signaling variant [WBPhenotype:0001841](3|2) (3|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SET domain0.0000002339Direct
Protein kinase-like (PK-like)0.000000485Direct
Integrin domains0.00003214Direct
Cdc48 domain 2-like0.00003214Direct
ADC-like0.00003214Direct
Calpain large subunit, middle domain (domain III)0.00005749Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0.0003331Direct
Lipovitellin-phosvitin complex, superhelical domain0.0003331Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0.0003778Direct
Fibronectin type III0.0004485Direct
PH domain-like0.001012Inherited
GroEL-intermediate domain like0.002588Inherited
GroEL equatorial domain-like0.002588Inherited
Voltage-gated potassium channels0.003581Inherited
cAMP-binding domain-like0.00449Inherited
Spectrin repeat0.00449Inherited
GroEL apical domain-like0.005281Inherited
F1F0 ATP synthase subunit C0.007376Inherited
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0.01783Inherited
DNA/RNA polymerases0.01783Inherited
Quinoprotein alcohol dehydrogenase-like0.01796Inherited
FYVE/PHD zinc finger0.0217Inherited
Translation proteins0.03743Inherited
CCCH zinc finger0.03743Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.03743Inherited
Immunoglobulin0.0398Inherited
SNARE-like0.06444Inherited
Clavaminate synthase-like0.09241Inherited
Cyclin-like0.1145Inherited
Sm-like ribonucleoproteins0.196Inherited
Transducin (alpha subunit), insertion domain0.2399Inherited
Nucleotide cyclase0.2618Inherited
Periplasmic binding protein-like I0.3071Inherited
Cytochrome P4500.5681Inherited
Homeodomain-like0.8435Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Integrin domains0Direct
Histone lysine methyltransferases0.00003795Direct
Cdc48 N-terminal domain-like0.00005594Direct
Cdc48 domain 2-like0.00005594Direct
Calpain large subunit, middle domain (domain III)0.0000572Direct
Protein kinases, catalytic subunit0.0001008Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0002429Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0.0003194Direct
Lipovitellin-phosvitin complex, superhelical domain0.0003194Direct
Calpain large subunit, catalytic domain (domain II)0.0004668Direct
Pleckstrin-homology domain (PH domain)0.0006302Direct
Spectrin repeat0.001545Inherited
Group II chaperonin (CCT, TRIC), intermediate domain0.001754Inherited
I set domains0.002881Inherited
F1F0 ATP synthase subunit C0.00708Inherited
Proteasome subunits0.008899Inherited
Group II chaperonin (CCT, TRIC), ATPase domain0.009691Inherited
Elongation factors0.009807Inherited
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0.01738Inherited
Group II chaperonin (CCT, TRIC), apical domain0.01805Inherited
Voltage-gated potassium channels0.01883Inherited
LIM domain0.03357Inherited
Clathrin adaptor core protein0.03357Inherited
CCCH zinc finger0.04Inherited
PHD domain0.04594Inherited
Transducin (alpha subunit), insertion domain0.2444Inherited
Adenylyl and guanylyl cyclase catalytic domain0.374Inherited
Cytochrome P4500.7389Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SET domain0.0000001892Direct
Protein kinase-like (PK-like)0.0000003931Direct
ADC-like0.00002641Direct
Cdc48 domain 2-like0.00002641Direct
Integrin domains0.00002641Direct
Calpain large subunit, middle domain (domain III)0.00004738Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0.0002762Direct
Lipovitellin-phosvitin complex, superhelical domain0.0002762Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0.0003134Direct
Fibronectin type III0.0003726Direct
PH domain-like0.0008482Direct
GroEL equatorial domain-like0.002187Inherited
GroEL-intermediate domain like0.002187Inherited
Voltage-gated potassium channels0.003038Inherited
Spectrin repeat0.003818Inherited
cAMP-binding domain-like0.003818Inherited
GroEL apical domain-like0.004499Inherited
F1F0 ATP synthase subunit C0.006319Inherited
DNA/RNA polymerases0.01546Inherited
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0.01546Inherited
Quinoprotein alcohol dehydrogenase-like0.01558Inherited
FYVE/PHD zinc finger0.01892Inherited
CCCH zinc finger0.03302Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.03302Inherited
Translation proteins0.03302Inherited
Immunoglobulin0.03516Inherited
SNARE-like0.0575Inherited
Clavaminate synthase-like0.08324Inherited
Cyclin-like0.1037Inherited
Sm-like ribonucleoproteins0.1804Inherited
Transducin (alpha subunit), insertion domain0.2224Inherited
Nucleotide cyclase0.2437Inherited
Periplasmic binding protein-like I0.2876Inherited
Cytochrome P4500.5459Inherited
Homeodomain-like0.8259Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0.00004738Direct
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.0002762Direct
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0.0002762Direct
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0.001577Inherited
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.002187Inherited
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.002187Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.003818Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.004202Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.004499Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.006319Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.008235Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.03386Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.03991Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2224Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.0002762Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.002187Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.006319Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.006319Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.02205Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.04994Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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