Worm Phenotype (WP): chemical response variant

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

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Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	Direct
Transducin (heterotrimeric G protein), gamma chain	0	Direct
Skp1 dimerisation domain-like	0.00000000002151	Direct
Nicotinic receptor ligand binding domain-like	0.0000000003903	Direct
Neurotransmitter-gated ion-channel transmembrane pore	0.0000000006708	Direct
Cullin repeat-like	0.00000005437	Direct
Protein kinase-like (PK-like)	0.0000001635	Direct
Cullin homology domain	0.000002807	Direct
Transducin (alpha subunit), insertion domain	0.000016	Direct
Nucleotide cyclase	0.0000186	Direct
cAMP-binding domain-like	0.00004963	Direct
Ligand-binding domain in the NO signalling and Golgi transport	0.0002042	Direct
ABC transporter transmembrane region	0.0007163	Direct
C2 domain (Calcium/lipid-binding domain, CaLB)	0.0007668	Direct
Periplasmic binding protein-like I	0.005545	Inherited
Cation efflux protein transmembrane domain-like	0.006671	Inherited
t-snare proteins	0.008563	Inherited
Myosin rod fragments	0.008563	Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0.009588	Inherited
Cation efflux protein cytoplasmic domain-like	0.009588	Inherited
EF-hand	0.01717	Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes	0.04656	Inherited
PRTase-like	0.04897	Inherited
Spectrin repeat	0.06109	Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions	0.06109	Inherited
Lipovitellin-phosvitin complex, superhelical domain	0.06109	Inherited
ENTH/VHS domain	0.0624	Inherited
TPR-like	0.07017	Inherited
Voltage-gated potassium channels	0.07936	Inherited
Periplasmic binding protein-like II	0.08304	Inherited
Cytochrome P450	0.08784	Inherited
Immunoglobulin	0.08784	Inherited
Metal cation-transporting ATPase, ATP-binding domain N	0.09102	Inherited
Calcium ATPase, transmembrane domain M	0.09102	Inherited
Calcium ATPase, transduction domain A	0.09102	Inherited
Troponin coil-coiled subunits	0.1023	Inherited
SH3-domain	0.1112	Inherited
Regulator of G-protein signaling, RGS	0.1268	Inherited
SAM/Pointed domain	0.1268	Inherited
Multidrug efflux transporter AcrB transmembrane domain	0.1321	Inherited
PDZ domain-like	0.136	Inherited
WD40 repeat-like	0.1505	Inherited
Cysteine-rich domain	0.1683	Inherited
PYP-like sensor domain (PAS domain)	0.1701	Inherited
SNARE-like	0.1875	Inherited
PH domain-like	0.1966	Inherited
EGF/Laminin	0.2355	Inherited
Glutathione synthetase ATP-binding domain-like	0.2424	Inherited
"Winged helix" DNA-binding domain	0.2549	Inherited
HMG-box	0.2791	Inherited
SNF-like	0.2791	Inherited
HAD-like	0.3026	Inherited
Cystine-knot cytokines	0.3354	Inherited
P-loop containing nucleoside triphosphate hydrolases	0.3528	Inherited
GroEL apical domain-like	0.3576	Inherited
GroEL equatorial domain-like	0.3576	Inherited
Lipocalins	0.3576	Inherited
GroEL-intermediate domain like	0.3576	Inherited
FAD/NAD(P)-binding domain	0.3826	Inherited
Bromodomain	0.4736	Inherited
Homeodomain-like	0.4803	Inherited
Cysteine proteinases	0.4812	Inherited
HSP20-like chaperones	0.5685	Inherited
Tubulin nucleotide-binding domain-like	0.5685	Inherited
DBL homology domain (DH-domain)	0.5997	Inherited
Thioredoxin-like	0.6486	Inherited
Tubulin C-terminal domain-like	0.7015	Inherited
Leucine zipper domain	0.7015	Inherited
Glucocorticoid receptor-like (DNA-binding domain)	0.8378	Inherited
GST C-terminal domain-like	0.8924	Inherited
HLH, helix-loop-helix DNA-binding domain	0.8967	Inherited
Sm-like ribonucleoproteins	0.966	Inherited
Nucleic acid-binding proteins	1	Inherited
Nucleotidylyl transferase	1	Inherited
Ankyrin repeat	1	Inherited
Nuclear receptor ligand-binding domain	1	Inherited
MFS general substrate transporter	1	Inherited
beta-beta-alpha zinc fingers	1	Inherited
Family A G protein-coupled receptor-like	1	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
Transducin (heterotrimeric G protein), gamma chain	0	Direct
Cullin repeat	0	Direct
SCF ubiquitin ligase complex WHB domain	0	Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	Direct
Quinoprotein alcohol dehydrogenase-like	0	Direct
Neurotransmitter-gated ion-channel transmembrane pore	0.000000001039	Direct
Nicotinic receptor ligand binding domain-like	0.000000001039	Direct
Skp1 dimerisation domain-like	0.00000000164	Direct
Protein kinases, catalytic subunit	0.000001196	Direct
Cullin homology domain	0.000007512	Direct
Transducin (alpha subunit), insertion domain	0.00001676	Direct
Adenylyl and guanylyl cyclase catalytic domain	0.00002048	Direct
cAMP-binding domain	0.00007178	Direct
ABC transporter transmembrane region	0.00118	Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain	0.001263	Inherited
H-NOX domain	0.001485	Inherited
Eps15 homology domain (EH domain)	0.001485	Inherited
BTB/POZ domain	0.005384	Inherited
Transforming growth factor (TGF)-beta	0.00603	Inherited
Cation efflux protein cytoplasmic domain-like	0.00603	Inherited
PLC-like (P variant)	0.01166	Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0.01493	Inherited
t-snare proteins	0.0151	Inherited
L-arabinose binding protein-like	0.01619	Inherited
Cation efflux protein transmembrane domain-like	0.02536	Inherited
G proteins	0.0261	Inherited
Phosphoribosyltransferases (PRTases)	0.0291	Inherited
Clathrin coat assembly domain	0.0291	Inherited
I set domains	0.03295	Inherited
Synaptotagmin-like (S variant)	0.03377	Inherited
ABC transporter ATPase domain-like	0.04775	Inherited
Pyridoxal-dependent decarboxylase	0.0571	Inherited
Lipovitellin-phosvitin complex, superhelical domain	0.0571	Inherited
Spectrin repeat	0.0571	Inherited
FAD/NAD-linked reductases, N-terminal and central domains	0.0571	Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions	0.0571	Inherited
Multidrug efflux transporter AcrB transmembrane domain	0.06112	Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes	0.07752	Inherited
Phosphate binding protein-like	0.07959	Inherited
Calcium ATPase, transduction domain A	0.08874	Inherited
PDZ domain	0.08874	Inherited
Metal cation-transporting ATPase, ATP-binding domain N	0.08874	Inherited
Pleckstrin-homology domain (PH domain)	0.1139	Inherited
SH3-domain	0.1139	Inherited
Regulator of G-protein signaling, RGS	0.1214	Inherited
Glutathione peroxidase-like	0.1296	Inherited
Group II chaperonin (CCT, TRIC), intermediate domain	0.1602	Inherited
Meta-cation ATPase, catalytic domain P	0.1835	Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)	0.2399	Inherited
Cytochrome P450	0.2413	Inherited
HMG-box	0.27	Inherited
SNF-like	0.27	Inherited
Erythroid transcription factor GATA-1	0.27	Inherited
WD40-repeat	0.2927	Inherited
Calcium ATPase, transmembrane domain M	0.3516	Inherited
Voltage-gated potassium channels	0.4486	Inherited
Group II chaperonin (CCT, TRIC), ATPase domain	0.4659	Inherited
Bromodomain	0.4659	Inherited
Group II chaperonin (CCT, TRIC), apical domain	0.4659	Inherited
Tubulin, GTPase domain	0.5642	Inherited
Fatty acid binding protein-like	0.5995	Inherited
DBL homology domain (DH-domain)	0.6005	Inherited
Homeodomain	0.6888	Inherited
Tubulin, C-terminal domain	0.7014	Inherited
Leucine zipper domain	0.7014	Inherited
Glutathione S-transferase (GST), N-terminal domain	0.738	Inherited
HLH, helix-loop-helix DNA-binding domain	0.8949	Inherited
Glutathione S-transferase (GST), C-terminal domain	0.9226	Inherited
Rhodopsin-like	0.9479	Inherited
Ankyrin repeat	1	Inherited
Nuclear receptor	1	Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain	1	Inherited
Nuclear receptor ligand-binding domain	1	Inherited

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Transducin (heterotrimeric G protein), gamma chain	0	Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	Direct
Skp1 dimerisation domain-like	0.00000000001698	Direct
Nicotinic receptor ligand binding domain-like	0.0000000003093	Direct
Neurotransmitter-gated ion-channel transmembrane pore	0.0000000005321	Direct
Cullin repeat-like	0.00000004349	Direct
Protein kinase-like (PK-like)	0.0000001311	Direct
Cullin homology domain	0.000002275	Direct
Transducin (alpha subunit), insertion domain	0.00001303	Direct
Nucleotide cyclase	0.00001516	Direct
cAMP-binding domain-like	0.00004059	Direct
Ligand-binding domain in the NO signalling and Golgi transport	0.0001677	Direct
ABC transporter transmembrane region	0.0005944	Direct
C2 domain (Calcium/lipid-binding domain, CaLB)	0.0006371	Direct
Periplasmic binding protein-like I	0.004716	Inherited
Cation efflux protein transmembrane domain-like	0.005688	Inherited
t-snare proteins	0.007339	Inherited
Myosin rod fragments	0.007339	Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0.008236	Inherited
Cation efflux protein cytoplasmic domain-like	0.008236	Inherited
EF-hand	0.0149	Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes	0.04117	Inherited
PRTase-like	0.04337	Inherited
Spectrin repeat	0.0544	Inherited
Lipovitellin-phosvitin complex, superhelical domain	0.0544	Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions	0.0544	Inherited
ENTH/VHS domain	0.0556	Inherited
TPR-like	0.06271	Inherited
Voltage-gated potassium channels	0.07117	Inherited
Periplasmic binding protein-like II	0.07458	Inherited
Immunoglobulin	0.07898	Inherited
Cytochrome P450	0.07898	Inherited
Metal cation-transporting ATPase, ATP-binding domain N	0.08193	Inherited
Calcium ATPase, transduction domain A	0.08193	Inherited
Calcium ATPase, transmembrane domain M	0.08193	Inherited
Troponin coil-coiled subunits	0.0924	Inherited
SH3-domain	0.1007	Inherited
Regulator of G-protein signaling, RGS	0.1152	Inherited
SAM/Pointed domain	0.1152	Inherited
Multidrug efflux transporter AcrB transmembrane domain	0.1201	Inherited
PDZ domain-like	0.1238	Inherited
WD40 repeat-like	0.1373	Inherited
Cysteine-rich domain	0.1542	Inherited
PYP-like sensor domain (PAS domain)	0.1559	Inherited
SNARE-like	0.1723	Inherited
PH domain-like	0.181	Inherited
EGF/Laminin	0.2181	Inherited
SMAD/FHA domain	0.2249	Inherited
Glutathione synthetase ATP-binding domain-like	0.2249	Inherited
"Winged helix" DNA-binding domain	0.237	Inherited
HMG-box	0.2605	Inherited
SNF-like	0.2605	Inherited
HAD-like	0.2834	Inherited
Cystine-knot cytokines	0.3157	Inherited
P-loop containing nucleoside triphosphate hydrolases	0.3326	Inherited
GroEL equatorial domain-like	0.3373	Inherited
Lipocalins	0.3373	Inherited
GroEL apical domain-like	0.3373	Inherited
GroEL-intermediate domain like	0.3373	Inherited
FAD/NAD(P)-binding domain	0.3621	Inherited
Bromodomain	0.4523	Inherited
Homeodomain-like	0.4588	Inherited
Cysteine proteinases	0.4598	Inherited
Tubulin nucleotide-binding domain-like	0.5467	Inherited
HSP20-like chaperones	0.5467	Inherited
DBL homology domain (DH-domain)	0.578	Inherited
Thioredoxin-like	0.6269	Inherited
Leucine zipper domain	0.6808	Inherited
Tubulin C-terminal domain-like	0.6808	Inherited
Glucocorticoid receptor-like (DNA-binding domain)	0.8202	Inherited
GST C-terminal domain-like	0.877	Inherited
HLH, helix-loop-helix DNA-binding domain	0.8815	Inherited
Sm-like ribonucleoproteins	0.9535	Inherited
Ankyrin repeat	1	Inherited
Nucleic acid-binding proteins	1	Inherited
beta-beta-alpha zinc fingers	1	Inherited
Family A G protein-coupled receptor-like	1	Inherited
Nuclear receptor ligand-binding domain	1	Inherited
MFS general substrate transporter	1	Inherited
Nucleotidylyl transferase	1	Inherited

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Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
75632,46785 75632 - Cullin homology domain 46785 - "Winged helix" DNA-binding domain	0	Direct
74788,75632 74788 - Cullin repeat-like 75632 - Cullin homology domain	0	Direct
63712,90112 63712 - Nicotinic receptor ligand binding domain-like 90112 - Neurotransmitter-gated ion-channel transmembrane pore	0.0000000005321	Direct
54695,81382 54695 - POZ domain 81382 - Skp1 dimerisation domain-like	0.0000000006013	Direct
56112,55073 56112 - Protein kinase-like (PK-like) 55073 - Nucleotide cyclase	0.0000009638	Direct
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0.00001303	Direct
90123,52540 90123 - ABC transporter transmembrane region 52540 - P-loop containing nucleoside triphosphate hydrolases	0.0005944	Direct
49265,48726 49265 - Fibronectin type III 48726 - Immunoglobulin	0.0007844	Direct
52540,90123 52540 - P-loop containing nucleoside triphosphate hydrolases 90123 - ABC transporter transmembrane region	0.0008261	Direct
48452,48452 48452 - TPR-like 48452 - TPR-like	0.001189	Inherited
50044,50044 50044 - SH3-domain 50044 - SH3-domain	0.001683	Inherited
51905,55424 51905 - FAD/NAD(P)-binding domain 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0.008236	Inherited
161111,160240 161111 - Cation efflux protein transmembrane domain-like 160240 - Cation efflux protein cytoplasmic domain-like	0.008236	Inherited
50978,50978 50978 - WD40 repeat-like 50978 - WD40 repeat-like	0.009093	Inherited
47473,47473 47473 - EF-hand 47473 - EF-hand	0.0544	Inherited
48431,56968 48431 - Lipovitellin-phosvitin complex, superhelical domain 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions	0.0544	Inherited
56968,48431 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions 48431 - Lipovitellin-phosvitin complex, superhelical domain	0.0544	Inherited
81660,56784 81660 - Metal cation-transporting ATPase, ATP-binding domain N 56784 - HAD-like	0.08193	Inherited
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat	0.0924	Inherited
49562,49562 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)	0.0924	Inherited
56784,81665 56784 - HAD-like 81665 - Calcium ATPase, transmembrane domain M	0.1201	Inherited
57889,57889 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain	0.2605	Inherited
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like	0.3373	Inherited
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0.3373	Inherited
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0.3957	Inherited
52490,55307 52490 - Tubulin nucleotide-binding domain-like 55307 - Tubulin C-terminal domain-like	0.5467	Inherited
56436,49854 56436 - C-type lectin-like 49854 - Spermadhesin, CUB domain	0.6629	Inherited
52833,47616 52833 - Thioredoxin-like 47616 - GST C-terminal domain-like	0.7458	Inherited
56436,56436 56436 - C-type lectin-like 56436 - C-type lectin-like	0.9242	Inherited
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain	1	Inherited

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Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
74788,75632,46785 74788 - Cullin repeat-like 75632 - Cullin homology domain 46785 - "Winged helix" DNA-binding domain	0	Direct
52540,52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0.0007844	Direct
52540,90123,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 90123 - ABC transporter transmembrane region 52540 - P-loop containing nucleoside triphosphate hydrolases	0.0008261	Direct
90123,52540,90123 90123 - ABC transporter transmembrane region 52540 - P-loop containing nucleoside triphosphate hydrolases 90123 - ABC transporter transmembrane region	0.0008261	Direct
56968,48431,56968 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions 48431 - Lipovitellin-phosvitin complex, superhelical domain 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions	0.0544	Inherited
81660,56784,81665 81660 - Metal cation-transporting ATPase, ATP-binding domain N 56784 - HAD-like 81665 - Calcium ATPase, transmembrane domain M	0.1201	Inherited
46966,46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat 46966 - Spectrin repeat	0.1559	Inherited
48592,54849,52029 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0.3373	Inherited
56436,56436,49854 56436 - C-type lectin-like 56436 - C-type lectin-like 49854 - Spermadhesin, CUB domain	0.4643	Inherited

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Worm Phenotype (WP): chemical response variant

Superfamily

Family

Supra-domain (including individual superfamily)