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Worm Phenotype (WP): chemical response variant
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
Skp1 dimerisation domain-like | 0.0000000000009406 | DIRECT |
Nicotinic receptor ligand binding domain-like | 0.000000000001228 | DIRECT |
Neurotransmitter-gated ion-channel transmembrane pore | 0.000000000002387 | DIRECT |
Cullin repeat-like | 0.000000009891 | DIRECT |
Cullin homology domain | 0.0000007544 | DIRECT |
Protein kinase-like (PK-like) | 0.0000009624 | DIRECT |
cAMP-binding domain-like | 0.00001046 | DIRECT |
C2 domain (Calcium/lipid-binding domain, CaLB) | 0.00001394 | DIRECT |
Transducin (alpha subunit), insertion domain | 0.0002654 | DIRECT |
Periplasmic binding protein-like I | 0.002462 | INHERITED FROM: magnesium chemotaxis defective || iodide chemotaxis variant || bromide chemotaxis variant || chemotaxis variant || benzaldehyde chemotaxis variant || aqueous chemosensory response variant || alkaline pH chemotaxis variant || diacetyl chemotaxis variant || AWC odorant chemotaxis defective || AWC odorant chemotaxis variant || chemosensory behavior variant || chemosensory response variant || bromide chemotaxis defective || lithium chemotaxis defective || iodide chemotaxis defective || aqueous positive chemotaxis variant |
Myosin rod fragments | 0.003839 | INHERITED FROM: drug resistant |
Quinoprotein alcohol dehydrogenase-like | 0.007825 | INHERITED FROM: drug response variant |
Voltage-gated potassium channels | 0.01824 | INHERITED FROM: adrenergic receptor antagonist response variant || positive chemotaxis defective || serotonin resistant || serotonin response variant |
Multidrug efflux transporter AcrB transmembrane domain | 0.0217 | INHERITED FROM: odorant positive chemotaxis defective || odorant chemosensory response variant || positive chemotaxis defective |
EF-hand | 0.02244 | INHERITED FROM: aldicarb response variant |
Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0.02287 | INHERITED FROM: drug hypersensitive |
Immunoglobulin | 0.02522 | INHERITED FROM: aldicarb response variant |
PRTase-like | 0.02693 | INHERITED FROM: drug resistant || Fluorouracil resistant |
Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.03135 | INHERITED FROM: unfolded protein response variant |
Spectrin repeat | 0.03135 | INHERITED FROM: drug response variant || aldicarb resistant || aldicarb response variant |
Lipovitellin-phosvitin complex, superhelical domain | 0.03135 | INHERITED FROM: unfolded protein response variant |
ENTH/VHS domain | 0.03137 | INHERITED FROM: acetylcholinesterase inhibitor resistant || aldicarb resistant |
TPR-like | 0.03146 | INHERITED FROM: ivermectin resistant || positive chemotaxis defective || ivermectin response variant |
Calcium ATPase, transmembrane domain M | 0.03687 | INHERITED FROM: nicotine hypersensitive |
Calcium ATPase, transduction domain A | 0.03687 | INHERITED FROM: nicotine hypersensitive |
Metal cation-transporting ATPase, ATP-binding domain N | 0.03687 | INHERITED FROM: nicotine hypersensitive |
Periplasmic binding protein-like II | 0.03784 | INHERITED FROM: response to food variant || chemotaxis variant || chemosensory behavior variant || chemosensory response variant || positive chemotaxis defective || aqueous positive chemotaxis defective || sodium chloride chemotaxis variant || sodium chloride chemotaxis defective || aqueous positive chemotaxis variant |
PDZ domain-like | 0.04229 | INHERITED FROM: aldicarb response variant || acetylcholinesterase inhibitor response variant |
WD40 repeat-like | 0.0456 | INHERITED FROM: aldicarb response variant || osmotic avoidance variant |
Troponin coil-coiled subunits | 0.05919 | INHERITED FROM: nicotine response variant || drug response variant |
SMAD/FHA domain | 0.05989 | INHERITED FROM: aldicarb response variant |
Glutathione synthetase ATP-binding domain-like | 0.05989 | INHERITED FROM: negative chemotaxis variant || chemotaxis variant || chemosensory behavior variant || chemosensory response variant || osmotic avoidance variant |
SAM/Pointed domain | 0.06482 | INHERITED FROM: aldicarb response variant |
Regulator of G-protein signaling, RGS | 0.06482 | INHERITED FROM: negative chemotaxis variant || chemotaxis variant |
Nucleotide cyclase | 0.06505 | INHERITED FROM: anion positive chemotaxis defective || magnesium chemotaxis defective || iodide chemotaxis variant || bromide chemotaxis variant || chemotaxis variant || aqueous chemosensory response variant || cation positive chemotaxis variant || alkaline pH chemotaxis variant || diacetyl chemotaxis variant || cation positive chemotaxis defective || positive chemotaxis variant || AWC odorant chemotaxis defective || AWC odorant chemotaxis variant || chemosensory behavior variant || chemosensory response variant || anion positive chemotaxis variant || osmotic avoidance variant || bromide chemotaxis defective || lithium chemotaxis defective || iodide chemotaxis defective |
Cysteine-rich domain | 0.06797 | INHERITED FROM: odorant chemosensory response variant || positive chemotaxis variant || odorant positive chemotaxis variant || aldicarb response variant |
EGF/Laminin | 0.08499 | INHERITED FROM: octanol chemotaxis variant || octanol chemotaxis defective || odorant negative chemotaxis defective |
SH3-domain | 0.1106 | INHERITED FROM: aldicarb response variant |
t-snare proteins | 0.1108 | INHERITED FROM: drug hypersensitive |
SNARE-like | 0.1148 | INHERITED FROM: acetylcholinesterase inhibitor resistant || aldicarb resistant |
SNF-like | 0.1797 | INHERITED FROM: drug hypersensitive |
PH domain-like | 0.2133 | INHERITED FROM: aldicarb response variant |
P-loop containing nucleoside triphosphate hydrolases | 0.2219 | INHERITED FROM: hydroxyurea response variant |
Cystine-knot cytokines | 0.2225 | INHERITED FROM: nicotine response variant || levamisole response variant |
GroEL equatorial domain-like | 0.2274 | INHERITED FROM: unfolded protein response variant |
GroEL-intermediate domain like | 0.2274 | INHERITED FROM: unfolded protein response variant |
GroEL apical domain-like | 0.2274 | INHERITED FROM: unfolded protein response variant |
Tubulin nucleotide-binding domain-like | 0.262 | INHERITED FROM: nicotine response variant |
HAD-like | 0.2669 | INHERITED FROM: nicotine hypersensitive |
POZ domain | 0.2708 | INHERITED FROM: chemical hypersensitive |
Bromodomain | 0.334 | INHERITED FROM: anesthetic response variant || ethanol resistant || acute functional tolerance to alcohol defective || anesthetic resistant || drug adaptation variant |
Tubulin C-terminal domain-like | 0.3887 | INHERITED FROM: nicotine response variant |
Sm-like ribonucleoproteins | 0.4719 | INHERITED FROM: unfolded protein response variant |
"Winged helix" DNA-binding domain | 0.48 | INHERITED FROM: anesthetic response variant || chemical hypersensitive |
ABC transporter transmembrane region | 0.6253 | INHERITED FROM: colchicine hypersensitive |
Leucine zipper domain | 0.6309 | INHERITED FROM: pore forming toxin response variant |
Glucocorticoid receptor-like (DNA-binding domain) | 0.6983 | INHERITED FROM: SDS sensitive dauer |
Homeodomain-like | 0.8081 | INHERITED FROM: egg laying imipramine resistant || imipramine resistant || adrenergic receptor antagonist response variant || inhibitor of serotonin uptake variant |
DBL homology domain (DH-domain) | 0.8339 | INHERITED FROM: aldicarb response variant |
Nucleic acid-binding proteins | 0.8566 | INHERITED FROM: hydroxyurea hypersensitive || hydroxyurea response variant |
HLH, helix-loop-helix DNA-binding domain | 0.9049 | INHERITED FROM: lysine chemotaxis defective || aqueous positive chemotaxis defective |
Nuclear receptor ligand-binding domain | 1 | INHERITED FROM: SDS sensitive dauer |
Ankyrin repeat | 1 | INHERITED FROM: chemotaxis variant || octanol chemotaxis variant || octanol chemotaxis defective || odorant negative chemotaxis defective |
Family A G protein-coupled receptor-like | 1 | INHERITED FROM: locomotion rate serotonin variant || serotonin induced fat reduction variant || male tail curling serotonin variant || serotonin induced pumping variant |
beta-beta-alpha zinc fingers | 1 | INHERITED FROM: egg laying imipramine resistant || imipramine resistant || inhibitor of serotonin uptake variant |
SCOP term | FDR (all) | Annotation (direct or inherited) |
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
Skp1 dimerisation domain-like | 0.0000000000009406 | Direct |
Nicotinic receptor ligand binding domain-like | 0.000000000001228 | Direct |
Neurotransmitter-gated ion-channel transmembrane pore | 0.000000000002387 | Direct |
Cullin repeat-like | 0.000000009891 | Direct |
Cullin homology domain | 0.0000007544 | Direct |
Protein kinase-like (PK-like) | 0.0000009624 | Direct |
cAMP-binding domain-like | 0.00001046 | Direct |
C2 domain (Calcium/lipid-binding domain, CaLB) | 0.00001394 | Direct |
Transducin (alpha subunit), insertion domain | 0.0002654 | Direct |
Periplasmic binding protein-like I | 0.002462 | Inherited |
Myosin rod fragments | 0.003839 | Inherited |
Quinoprotein alcohol dehydrogenase-like | 0.007825 | Inherited |
Voltage-gated potassium channels | 0.01824 | Inherited |
Multidrug efflux transporter AcrB transmembrane domain | 0.0217 | Inherited |
EF-hand | 0.02244 | Inherited |
Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0.02287 | Inherited |
Immunoglobulin | 0.02522 | Inherited |
PRTase-like | 0.02693 | Inherited |
Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.03135 | Inherited |
Spectrin repeat | 0.03135 | Inherited |
Lipovitellin-phosvitin complex, superhelical domain | 0.03135 | Inherited |
ENTH/VHS domain | 0.03137 | Inherited |
TPR-like | 0.03146 | Inherited |
Calcium ATPase, transmembrane domain M | 0.03687 | Inherited |
Calcium ATPase, transduction domain A | 0.03687 | Inherited |
Metal cation-transporting ATPase, ATP-binding domain N | 0.03687 | Inherited |
Periplasmic binding protein-like II | 0.03784 | Inherited |
PDZ domain-like | 0.04229 | Inherited |
WD40 repeat-like | 0.0456 | Inherited |
Troponin coil-coiled subunits | 0.05919 | Inherited |
SMAD/FHA domain | 0.05989 | Inherited |
Glutathione synthetase ATP-binding domain-like | 0.05989 | Inherited |
SAM/Pointed domain | 0.06482 | Inherited |
Regulator of G-protein signaling, RGS | 0.06482 | Inherited |
Nucleotide cyclase | 0.06505 | Inherited |
Cysteine-rich domain | 0.06797 | Inherited |
EGF/Laminin | 0.08499 | Inherited |
SH3-domain | 0.1106 | Inherited |
t-snare proteins | 0.1108 | Inherited |
SNARE-like | 0.1148 | Inherited |
SNF-like | 0.1797 | Inherited |
PH domain-like | 0.2133 | Inherited |
P-loop containing nucleoside triphosphate hydrolases | 0.2219 | Inherited |
Cystine-knot cytokines | 0.2225 | Inherited |
GroEL equatorial domain-like | 0.2274 | Inherited |
GroEL-intermediate domain like | 0.2274 | Inherited |
GroEL apical domain-like | 0.2274 | Inherited |
Tubulin nucleotide-binding domain-like | 0.262 | Inherited |
HAD-like | 0.2669 | Inherited |
POZ domain | 0.2708 | Inherited |
Bromodomain | 0.334 | Inherited |
Tubulin C-terminal domain-like | 0.3887 | Inherited |
Sm-like ribonucleoproteins | 0.4719 | Inherited |
"Winged helix" DNA-binding domain | 0.48 | Inherited |
ABC transporter transmembrane region | 0.6253 | Inherited |
Leucine zipper domain | 0.6309 | Inherited |
Glucocorticoid receptor-like (DNA-binding domain) | 0.6983 | Inherited |
Homeodomain-like | 0.8081 | Inherited |
DBL homology domain (DH-domain) | 0.8339 | Inherited |
Nucleic acid-binding proteins | 0.8566 | Inherited |
HLH, helix-loop-helix DNA-binding domain | 0.9049 | Inherited |
Nuclear receptor ligand-binding domain | 1 | Inherited |
Ankyrin repeat | 1 | Inherited |
Family A G protein-coupled receptor-like | 1 | Inherited |
beta-beta-alpha zinc fingers | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this WP term (SDWP level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
Quinoprotein alcohol dehydrogenase-like | 0 | DIRECT |
SCF ubiquitin ligase complex WHB domain | 0 | DIRECT |
Cullin repeat | 0 | DIRECT |
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
Neurotransmitter-gated ion-channel transmembrane pore | 0.000000000007123 | DIRECT |
Nicotinic receptor ligand binding domain-like | 0.000000000007123 | DIRECT |
Skp1 dimerisation domain-like | 0.0000000001108 | DIRECT |
Protein kinases, catalytic subunit | 0.0000002225 | DIRECT |
Cullin homology domain | 0.000002233 | DIRECT |
cAMP-binding domain | 0.00001692 | DIRECT |
Transducin (alpha subunit), insertion domain | 0.0003371 | DIRECT |
DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.0005541 | DIRECT |
Eps15 homology domain (EH domain) | 0.0007548 | DIRECT |
BTB/POZ domain | 0.001715 | INHERITED FROM: chemical hypersensitive |
Transforming growth factor (TGF)-beta | 0.003158 | INHERITED FROM: nicotine response variant || drug response variant || levamisole response variant |
PLC-like (P variant) | 0.004607 | INHERITED FROM: positive chemotaxis variant || aldicarb resistant || aldicarb response variant |
Synaptotagmin-like (S variant) | 0.006387 | INHERITED FROM: drug resistant || drug response variant || acetylcholinesterase inhibitor resistant || acetylcholinesterase inhibitor response variant |
G proteins | 0.01033 | INHERITED FROM: chemotaxis variant || chemosensory behavior variant || chemosensory response variant || aldicarb response variant |
L-arabinose binding protein-like | 0.01278 | INHERITED FROM: anion positive chemotaxis defective || magnesium chemotaxis defective || iodide chemotaxis variant || bromide chemotaxis variant || chemotaxis variant || cation positive chemotaxis variant || alkaline pH chemotaxis variant || cation positive chemotaxis defective || chemosensory behavior variant || chemosensory response variant || anion positive chemotaxis variant || bromide chemotaxis defective || lithium chemotaxis defective || iodide chemotaxis defective || aqueous positive chemotaxis variant |
I set domains | 0.01302 | INHERITED FROM: aldicarb resistant || aldicarb response variant |
Clathrin coat assembly domain | 0.01605 | INHERITED FROM: drug resistant || acetylcholinesterase inhibitor resistant || aldicarb resistant || aldicarb response variant || acetylcholinesterase inhibitor response variant |
Phosphoribosyltransferases (PRTases) | 0.01605 | INHERITED FROM: drug resistant || Fluorouracil resistant |
Multidrug efflux transporter AcrB transmembrane domain | 0.02276 | INHERITED FROM: odorant positive chemotaxis defective || odorant chemosensory response variant || positive chemotaxis defective |
Spectrin repeat | 0.0311 | INHERITED FROM: drug response variant || aldicarb resistant || aldicarb response variant |
Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.0311 | INHERITED FROM: unfolded protein response variant |
Lipovitellin-phosvitin complex, superhelical domain | 0.0311 | INHERITED FROM: unfolded protein response variant |
Pleckstrin-homology domain (PH domain) | 0.0377 | INHERITED FROM: egg laying imipramine resistant || diacetyl chemotaxis variant || egg laying serotonin variant || AWA odorant chemotaxis variant || aldicarb response variant |
Phosphate binding protein-like | 0.03905 | INHERITED FROM: response to food variant || chemotaxis variant || chemosensory behavior variant || chemosensory response variant || positive chemotaxis defective || aqueous positive chemotaxis defective || sodium chloride chemotaxis variant || sodium chloride chemotaxis defective || aqueous positive chemotaxis variant |
Calcium ATPase, transduction domain A | 0.03932 | INHERITED FROM: nicotine hypersensitive || drug hypersensitive |
Metal cation-transporting ATPase, ATP-binding domain N | 0.03932 | INHERITED FROM: nicotine hypersensitive || drug hypersensitive |
PDZ domain | 0.03932 | INHERITED FROM: egg laying serotonin variant || drug response variant || aldicarb response variant |
Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0.04116 | INHERITED FROM: drug hypersensitive |
Regulator of G-protein signaling, RGS | 0.0662 | INHERITED FROM: negative chemotaxis variant || chemotaxis variant |
Adenylyl and guanylyl cyclase catalytic domain | 0.07647 | INHERITED FROM: anion positive chemotaxis defective || magnesium chemotaxis defective || iodide chemotaxis variant || bromide chemotaxis variant || chemotaxis variant || aqueous chemosensory response variant || cation positive chemotaxis variant || alkaline pH chemotaxis variant || diacetyl chemotaxis variant || cation positive chemotaxis defective || positive chemotaxis variant || AWC odorant chemotaxis defective || AWC odorant chemotaxis variant || chemosensory behavior variant || chemosensory response variant || osmotic avoidance variant || bromide chemotaxis defective || lithium chemotaxis defective || iodide chemotaxis defective |
Meta-cation ATPase, catalytic domain P | 0.09926 | INHERITED FROM: nicotine hypersensitive |
t-snare proteins | 0.1078 | INHERITED FROM: drug hypersensitive |
Group II chaperonin (CCT, TRIC), intermediate domain | 0.1078 | INHERITED FROM: unfolded protein response variant |
SH3-domain | 0.1245 | INHERITED FROM: aldicarb response variant |
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.1296 | INHERITED FROM: drug resistant || odorant positive chemotaxis variant || aldicarb response variant |
WD40-repeat | 0.1634 | INHERITED FROM: ivermectin resistant || ivermectin response variant || osmotic avoidance variant |
SNF-like | 0.1799 | INHERITED FROM: drug hypersensitive |
Pyridoxal-dependent decarboxylase | 0.1799 | INHERITED FROM: egg laying response to drug variant |
Voltage-gated potassium channels | 0.2009 | INHERITED FROM: adrenergic receptor antagonist response variant || serotonin resistant || serotonin response variant |
Calcium ATPase, transmembrane domain M | 0.2318 | INHERITED FROM: nicotine hypersensitive || drug response variant |
Tubulin, GTPase domain | 0.2713 | INHERITED FROM: nicotine response variant |
FYVE, a phosphatidylinositol-3-phosphate binding domain | 0.2859 | INHERITED FROM: aldicarb resistant |
Group II chaperonin (CCT, TRIC), ATPase domain | 0.339 | INHERITED FROM: unfolded protein response variant |
Group II chaperonin (CCT, TRIC), apical domain | 0.339 | INHERITED FROM: unfolded protein response variant |
Bromodomain | 0.339 | INHERITED FROM: anesthetic response variant || ethanol resistant || acute functional tolerance to alcohol defective || anesthetic resistant || drug adaptation variant |
Tubulin, C-terminal domain | 0.4017 | INHERITED FROM: nicotine response variant |
Leucine zipper domain | 0.6477 | INHERITED FROM: pore forming toxin response variant |
Rhodopsin-like | 0.7108 | INHERITED FROM: egg laying response to drug variant || locomotion rate serotonin variant || serotonin hypersensitive || serotonin induced fat reduction variant || male tail curling serotonin variant || serotonin induced pumping variant || aqueous adaptation defective || biogenic amine receptor antagonist resistant || serotonin resistant || drug withdrawal response variant || serotonin response variant |
ABC transporter transmembrane region | 0.7465 | INHERITED FROM: colchicine hypersensitive |
DBL homology domain (DH-domain) | 0.8488 | INHERITED FROM: aldicarb response variant |
ABC transporter ATPase domain-like | 0.8659 | INHERITED FROM: colchicine hypersensitive |
HLH, helix-loop-helix DNA-binding domain | 0.9153 | INHERITED FROM: lysine chemotaxis defective || aqueous positive chemotaxis defective |
Nuclear receptor ligand-binding domain | 1 | INHERITED FROM: SDS sensitive dauer |
Ankyrin repeat | 1 | INHERITED FROM: octanol chemotaxis variant || octanol chemotaxis defective || odorant negative chemotaxis defective |
Nuclear receptor | 1 | INHERITED FROM: SDS sensitive dauer |
SCOP term | FDR (all) | Annotation (direct or inherited) |
Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
Quinoprotein alcohol dehydrogenase-like | 0 | Direct |
SCF ubiquitin ligase complex WHB domain | 0 | Direct |
Cullin repeat | 0 | Direct |
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
Neurotransmitter-gated ion-channel transmembrane pore | 0.000000000007123 | Direct |
Nicotinic receptor ligand binding domain-like | 0.000000000007123 | Direct |
Skp1 dimerisation domain-like | 0.0000000001108 | Direct |
Protein kinases, catalytic subunit | 0.0000002225 | Direct |
Cullin homology domain | 0.000002233 | Direct |
cAMP-binding domain | 0.00001692 | Direct |
Transducin (alpha subunit), insertion domain | 0.0003371 | Direct |
DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.0005541 | Direct |
Eps15 homology domain (EH domain) | 0.0007548 | Direct |
BTB/POZ domain | 0.001715 | Inherited |
Transforming growth factor (TGF)-beta | 0.003158 | Inherited |
PLC-like (P variant) | 0.004607 | Inherited |
Synaptotagmin-like (S variant) | 0.006387 | Inherited |
G proteins | 0.01033 | Inherited |
L-arabinose binding protein-like | 0.01278 | Inherited |
I set domains | 0.01302 | Inherited |
Clathrin coat assembly domain | 0.01605 | Inherited |
Phosphoribosyltransferases (PRTases) | 0.01605 | Inherited |
Multidrug efflux transporter AcrB transmembrane domain | 0.02276 | Inherited |
Spectrin repeat | 0.0311 | Inherited |
Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.0311 | Inherited |
Lipovitellin-phosvitin complex, superhelical domain | 0.0311 | Inherited |
Pleckstrin-homology domain (PH domain) | 0.0377 | Inherited |
Phosphate binding protein-like | 0.03905 | Inherited |
Calcium ATPase, transduction domain A | 0.03932 | Inherited |
Metal cation-transporting ATPase, ATP-binding domain N | 0.03932 | Inherited |
PDZ domain | 0.03932 | Inherited |
Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0.04116 | Inherited |
Regulator of G-protein signaling, RGS | 0.0662 | Inherited |
Adenylyl and guanylyl cyclase catalytic domain | 0.07647 | Inherited |
Meta-cation ATPase, catalytic domain P | 0.09926 | Inherited |
t-snare proteins | 0.1078 | Inherited |
Group II chaperonin (CCT, TRIC), intermediate domain | 0.1078 | Inherited |
SH3-domain | 0.1245 | Inherited |
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.1296 | Inherited |
WD40-repeat | 0.1634 | Inherited |
SNF-like | 0.1799 | Inherited |
Pyridoxal-dependent decarboxylase | 0.1799 | Inherited |
Voltage-gated potassium channels | 0.2009 | Inherited |
Calcium ATPase, transmembrane domain M | 0.2318 | Inherited |
Tubulin, GTPase domain | 0.2713 | Inherited |
FYVE, a phosphatidylinositol-3-phosphate binding domain | 0.2859 | Inherited |
Group II chaperonin (CCT, TRIC), ATPase domain | 0.339 | Inherited |
Group II chaperonin (CCT, TRIC), apical domain | 0.339 | Inherited |
Bromodomain | 0.339 | Inherited |
Tubulin, C-terminal domain | 0.4017 | Inherited |
Leucine zipper domain | 0.6477 | Inherited |
Rhodopsin-like | 0.7108 | Inherited |
ABC transporter transmembrane region | 0.7465 | Inherited |
DBL homology domain (DH-domain) | 0.8488 | Inherited |
ABC transporter ATPase domain-like | 0.8659 | Inherited |
HLH, helix-loop-helix DNA-binding domain | 0.9153 | Inherited |
Nuclear receptor ligand-binding domain | 1 | Inherited |
Ankyrin repeat | 1 | Inherited |
Nuclear receptor | 1 | Inherited |
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this WP term (SPWP level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
Skp1 dimerisation domain-like | 0.0000000000007435 | DIRECT |
Nicotinic receptor ligand binding domain-like | 0.0000000000009712 | DIRECT |
Neurotransmitter-gated ion-channel transmembrane pore | 0.000000000001889 | DIRECT |
Cullin repeat-like | 0.000000007914 | DIRECT |
Cullin homology domain | 0.0000006109 | DIRECT |
Protein kinase-like (PK-like) | 0.0000007801 | DIRECT |
cAMP-binding domain-like | 0.00000853 | DIRECT |
C2 domain (Calcium/lipid-binding domain, CaLB) | 0.00001139 | DIRECT |
Transducin (alpha subunit), insertion domain | 0.0002193 | DIRECT |
Periplasmic binding protein-like I | 0.002076 | INHERITED FROM: AWC odorant chemotaxis variant || benzaldehyde chemotaxis variant || lithium chemotaxis defective || bromide chemotaxis defective || iodide chemotaxis defective || AWC odorant chemotaxis defective || chemotaxis variant || aqueous chemosensory response variant || magnesium chemotaxis defective || iodide chemotaxis variant || chemosensory behavior variant || aqueous positive chemotaxis variant || bromide chemotaxis variant || diacetyl chemotaxis variant || alkaline pH chemotaxis variant || chemosensory response variant |
Myosin rod fragments | 0.003255 | INHERITED FROM: drug resistant |
Quinoprotein alcohol dehydrogenase-like | 0.006707 | INHERITED FROM: drug response variant |
Voltage-gated potassium channels | 0.01583 | INHERITED FROM: adrenergic receptor antagonist response variant || serotonin response variant || positive chemotaxis defective || serotonin resistant |
Multidrug efflux transporter AcrB transmembrane domain | 0.01892 | INHERITED FROM: odorant chemosensory response variant || odorant positive chemotaxis defective || positive chemotaxis defective |
EF-hand | 0.01958 | INHERITED FROM: aldicarb response variant |
Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0.01997 | INHERITED FROM: drug hypersensitive |
Immunoglobulin | 0.02207 | INHERITED FROM: aldicarb response variant |
PRTase-like | 0.0236 | INHERITED FROM: drug resistant || Fluorouracil resistant |
Spectrin repeat | 0.02756 | INHERITED FROM: aldicarb resistant || drug response variant || aldicarb response variant |
Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.02756 | INHERITED FROM: unfolded protein response variant |
Lipovitellin-phosvitin complex, superhelical domain | 0.02756 | INHERITED FROM: unfolded protein response variant |
ENTH/VHS domain | 0.02758 | INHERITED FROM: aldicarb resistant || acetylcholinesterase inhibitor resistant |
TPR-like | 0.02767 | INHERITED FROM: ivermectin resistant || ivermectin response variant || positive chemotaxis defective |
Calcium ATPase, transduction domain A | 0.03253 | INHERITED FROM: nicotine hypersensitive |
Metal cation-transporting ATPase, ATP-binding domain N | 0.03253 | INHERITED FROM: nicotine hypersensitive |
Calcium ATPase, transmembrane domain M | 0.03253 | INHERITED FROM: nicotine hypersensitive |
Periplasmic binding protein-like II | 0.0334 | INHERITED FROM: sodium chloride chemotaxis variant || chemotaxis variant || aqueous positive chemotaxis defective || positive chemotaxis defective || chemosensory behavior variant || aqueous positive chemotaxis variant || response to food variant || sodium chloride chemotaxis defective || chemosensory response variant |
PDZ domain-like | 0.03739 | INHERITED FROM: acetylcholinesterase inhibitor response variant || drug resistant || aldicarb response variant |
WD40 repeat-like | 0.04039 | INHERITED FROM: aldicarb response variant || osmotic avoidance variant |
Troponin coil-coiled subunits | 0.05273 | INHERITED FROM: nicotine response variant || drug response variant |
Glutathione synthetase ATP-binding domain-like | 0.05338 | INHERITED FROM: chemotaxis variant || negative chemotaxis variant || chemosensory behavior variant || osmotic avoidance variant || chemosensory response variant |
SMAD/FHA domain | 0.05338 | INHERITED FROM: aldicarb response variant |
Regulator of G-protein signaling, RGS | 0.05786 | INHERITED FROM: chemotaxis variant || negative chemotaxis variant || chemosensory behavior variant || chemosensory response variant |
SAM/Pointed domain | 0.05786 | INHERITED FROM: aldicarb response variant |
Nucleotide cyclase | 0.05809 | INHERITED FROM: cation positive chemotaxis defective || AWC odorant chemotaxis variant || lithium chemotaxis defective || bromide chemotaxis defective || positive chemotaxis variant || iodide chemotaxis defective || AWC odorant chemotaxis defective || chemotaxis variant || aqueous chemosensory response variant || magnesium chemotaxis defective || iodide chemotaxis variant || cation positive chemotaxis variant || anion positive chemotaxis defective || chemosensory behavior variant || anion positive chemotaxis variant || bromide chemotaxis variant || diacetyl chemotaxis variant || osmotic avoidance variant || alkaline pH chemotaxis variant || chemosensory response variant |
Cysteine-rich domain | 0.06076 | INHERITED FROM: odorant chemosensory response variant || positive chemotaxis variant || odorant positive chemotaxis variant || acetylcholinesterase inhibitor response variant || aldicarb response variant |
EGF/Laminin | 0.07653 | INHERITED FROM: octanol chemotaxis defective || odorant negative chemotaxis defective || octanol chemotaxis variant |
SH3-domain | 0.1001 | INHERITED FROM: aldicarb response variant |
t-snare proteins | 0.1003 | INHERITED FROM: drug hypersensitive |
SNARE-like | 0.1041 | INHERITED FROM: aldicarb resistant || acetylcholinesterase inhibitor resistant |
SNF-like | 0.165 | INHERITED FROM: drug hypersensitive |
PH domain-like | 0.197 | INHERITED FROM: aldicarb response variant || diacetyl chemotaxis variant |
P-loop containing nucleoside triphosphate hydrolases | 0.2052 | INHERITED FROM: hydroxyurea response variant |
Cystine-knot cytokines | 0.2058 | INHERITED FROM: nicotine response variant || levamisole response variant |
WW domain | 0.2105 | INHERITED FROM: aldicarb resistant |
GroEL apical domain-like | 0.2105 | INHERITED FROM: unfolded protein response variant |
GroEL equatorial domain-like | 0.2105 | INHERITED FROM: unfolded protein response variant |
GroEL-intermediate domain like | 0.2105 | INHERITED FROM: unfolded protein response variant |
Tubulin nucleotide-binding domain-like | 0.244 | INHERITED FROM: nicotine response variant |
HAD-like | 0.2488 | INHERITED FROM: nicotine hypersensitive |
POZ domain | 0.2525 | INHERITED FROM: chemical hypersensitive |
Bromodomain | 0.3142 | INHERITED FROM: ethanol resistant || anesthetic resistant || anesthetic response variant || acute functional tolerance to alcohol defective || drug adaptation variant |
Tubulin C-terminal domain-like | 0.3681 | INHERITED FROM: nicotine response variant |
Sm-like ribonucleoproteins | 0.4507 | INHERITED FROM: unfolded protein response variant |
"Winged helix" DNA-binding domain | 0.4589 | INHERITED FROM: chemical hypersensitive || anesthetic response variant |
ABC transporter transmembrane region | 0.6035 | INHERITED FROM: colchicine hypersensitive |
Leucine zipper domain | 0.6092 | INHERITED FROM: pore forming toxin response variant |
Glucocorticoid receptor-like (DNA-binding domain) | 0.6775 | INHERITED FROM: SDS sensitive dauer |
Homeodomain-like | 0.7897 | INHERITED FROM: adrenergic receptor antagonist response variant || inhibitor of serotonin uptake variant || egg laying imipramine resistant || imipramine resistant |
DBL homology domain (DH-domain) | 0.8163 | INHERITED FROM: aldicarb response variant |
Nucleic acid-binding proteins | 0.8402 | INHERITED FROM: hydroxyurea response variant || hydroxyurea hypersensitive |
HLH, helix-loop-helix DNA-binding domain | 0.8899 | INHERITED FROM: lysine chemotaxis defective || aqueous positive chemotaxis defective |
Family A G protein-coupled receptor-like | 1 | INHERITED FROM: serotonin induced pumping variant || serotonin induced fat reduction variant || male tail curling serotonin variant || locomotion rate serotonin variant |
Nuclear receptor ligand-binding domain | 1 | INHERITED FROM: SDS sensitive dauer |
Ankyrin repeat | 1 | INHERITED FROM: octanol chemotaxis defective || chemotaxis variant || odorant negative chemotaxis defective || octanol chemotaxis variant |
beta-beta-alpha zinc fingers | 1 | INHERITED FROM: inhibitor of serotonin uptake variant || egg laying imipramine resistant || imipramine resistant || egg laying serotonin resistant |
Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
Skp1 dimerisation domain-like | 0.0000000000007435 | Direct |
Nicotinic receptor ligand binding domain-like | 0.0000000000009712 | Direct |
Neurotransmitter-gated ion-channel transmembrane pore | 0.000000000001889 | Direct |
Cullin repeat-like | 0.000000007914 | Direct |
Cullin homology domain | 0.0000006109 | Direct |
Protein kinase-like (PK-like) | 0.0000007801 | Direct |
cAMP-binding domain-like | 0.00000853 | Direct |
C2 domain (Calcium/lipid-binding domain, CaLB) | 0.00001139 | Direct |
Transducin (alpha subunit), insertion domain | 0.0002193 | Direct |
Periplasmic binding protein-like I | 0.002076 | Inherited |
Myosin rod fragments | 0.003255 | Inherited |
Quinoprotein alcohol dehydrogenase-like | 0.006707 | Inherited |
Voltage-gated potassium channels | 0.01583 | Inherited |
Multidrug efflux transporter AcrB transmembrane domain | 0.01892 | Inherited |
EF-hand | 0.01958 | Inherited |
Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0.01997 | Inherited |
Immunoglobulin | 0.02207 | Inherited |
PRTase-like | 0.0236 | Inherited |
Spectrin repeat | 0.02756 | Inherited |
Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.02756 | Inherited |
Lipovitellin-phosvitin complex, superhelical domain | 0.02756 | Inherited |
ENTH/VHS domain | 0.02758 | Inherited |
TPR-like | 0.02767 | Inherited |
Calcium ATPase, transduction domain A | 0.03253 | Inherited |
Metal cation-transporting ATPase, ATP-binding domain N | 0.03253 | Inherited |
Calcium ATPase, transmembrane domain M | 0.03253 | Inherited |
Periplasmic binding protein-like II | 0.0334 | Inherited |
PDZ domain-like | 0.03739 | Inherited |
WD40 repeat-like | 0.04039 | Inherited |
Troponin coil-coiled subunits | 0.05273 | Inherited |
Glutathione synthetase ATP-binding domain-like | 0.05338 | Inherited |
SMAD/FHA domain | 0.05338 | Inherited |
Regulator of G-protein signaling, RGS | 0.05786 | Inherited |
SAM/Pointed domain | 0.05786 | Inherited |
Nucleotide cyclase | 0.05809 | Inherited |
Cysteine-rich domain | 0.06076 | Inherited |
EGF/Laminin | 0.07653 | Inherited |
SH3-domain | 0.1001 | Inherited |
t-snare proteins | 0.1003 | Inherited |
SNARE-like | 0.1041 | Inherited |
SNF-like | 0.165 | Inherited |
PH domain-like | 0.197 | Inherited |
P-loop containing nucleoside triphosphate hydrolases | 0.2052 | Inherited |
Cystine-knot cytokines | 0.2058 | Inherited |
WW domain | 0.2105 | Inherited |
GroEL apical domain-like | 0.2105 | Inherited |
GroEL equatorial domain-like | 0.2105 | Inherited |
GroEL-intermediate domain like | 0.2105 | Inherited |
Tubulin nucleotide-binding domain-like | 0.244 | Inherited |
HAD-like | 0.2488 | Inherited |
POZ domain | 0.2525 | Inherited |
Bromodomain | 0.3142 | Inherited |
Tubulin C-terminal domain-like | 0.3681 | Inherited |
Sm-like ribonucleoproteins | 0.4507 | Inherited |
"Winged helix" DNA-binding domain | 0.4589 | Inherited |
ABC transporter transmembrane region | 0.6035 | Inherited |
Leucine zipper domain | 0.6092 | Inherited |
Glucocorticoid receptor-like (DNA-binding domain) | 0.6775 | Inherited |
Homeodomain-like | 0.7897 | Inherited |
DBL homology domain (DH-domain) | 0.8163 | Inherited |
Nucleic acid-binding proteins | 0.8402 | Inherited |
HLH, helix-loop-helix DNA-binding domain | 0.8899 | Inherited |
Family A G protein-coupled receptor-like | 1 | Inherited |
Nuclear receptor ligand-binding domain | 1 | Inherited |
Ankyrin repeat | 1 | Inherited |
beta-beta-alpha zinc fingers | 1 | Inherited |
(show details)
Supra-domains annotated to this WP term (SPWP level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
74788,75632 74788 - Cullin repeat-like 75632 - Cullin homology domain | 0 | DIRECT |
75632,46785 75632 - Cullin homology domain 46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
63712,90112 63712 - Nicotinic receptor ligand binding domain-like 90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.000000000001889 | DIRECT |
54695,81382 54695 - POZ domain 81382 - Skp1 dimerisation domain-like | 0.00000000003856 | DIRECT |
56112,55073 56112 - Protein kinase-like (PK-like) 55073 - Nucleotide cyclase | 0.0000001014 | DIRECT |
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0002193 | DIRECT |
48452,48452 48452 - TPR-like 48452 - TPR-like | 0.000255 | DIRECT |
49265,48726 49265 - Fibronectin type III 48726 - Immunoglobulin | 0.0003767 | DIRECT |
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.0005462 | DIRECT |
50044,50044 50044 - SH3-domain 50044 - SH3-domain | 0.0007086 | DIRECT |
49562,49562 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.01997 | INHERITED FROM: drug resistant |
56968,48431 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions 48431 - Lipovitellin-phosvitin complex, superhelical domain | 0.02756 | INHERITED FROM: unfolded protein response variant |
47473,47473 47473 - EF-hand 47473 - EF-hand | 0.02756 | INHERITED FROM: drug response variant || acetylcholinesterase inhibitor response variant || aldicarb response variant |
48431,56968 48431 - Lipovitellin-phosvitin complex, superhelical domain 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.02756 | INHERITED FROM: unfolded protein response variant |
81660,56784 81660 - Metal cation-transporting ATPase, ATP-binding domain N 56784 - HAD-like | 0.03253 | INHERITED FROM: nicotine hypersensitive |
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat | 0.05273 | INHERITED FROM: drug response variant |
50978,50978 50978 - WD40 repeat-like 50978 - WD40 repeat-like | 0.05273 | INHERITED FROM: odorant chemosensory response variant || positive chemotaxis variant || ivermectin resistant || ivermectin response variant || chemotaxis variant || aqueous positive chemotaxis defective || aqueous chemosensory response variant || positive chemotaxis defective || negative chemotaxis variant || chemosensory behavior variant || drug resistant || aqueous positive chemotaxis variant || osmotic avoidance variant || chemosensory response variant |
56784,81665 56784 - HAD-like 81665 - Calcium ATPase, transmembrane domain M | 0.05338 | INHERITED FROM: nicotine hypersensitive |
57889,57889 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain | 0.165 | INHERITED FROM: drug response variant || drug resistant || aldicarb response variant |
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like | 0.2105 | INHERITED FROM: unfolded protein response variant |
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0.2105 | INHERITED FROM: unfolded protein response variant |
52490,55307 52490 - Tubulin nucleotide-binding domain-like 55307 - Tubulin C-terminal domain-like | 0.244 | INHERITED FROM: nicotine response variant |
90123,52540 90123 - ABC transporter transmembrane region 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.6035 | INHERITED FROM: colchicine hypersensitive |
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like | 0.7359 | INHERITED FROM: aldicarb response variant |
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain | 0.9377 | INHERITED FROM: chemical hypersensitive || SDS sensitive dauer |
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
74788,75632 74788 - Cullin repeat-like 75632 - Cullin homology domain | 0 | Direct |
75632,46785 75632 - Cullin homology domain 46785 - "Winged helix" DNA-binding domain | 0 | Direct |
63712,90112 63712 - Nicotinic receptor ligand binding domain-like 90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.000000000001889 | Direct |
54695,81382 54695 - POZ domain 81382 - Skp1 dimerisation domain-like | 0.00000000003856 | Direct |
56112,55073 56112 - Protein kinase-like (PK-like) 55073 - Nucleotide cyclase | 0.0000001014 | Direct |
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0002193 | Direct |
48452,48452 48452 - TPR-like 48452 - TPR-like | 0.000255 | Direct |
49265,48726 49265 - Fibronectin type III 48726 - Immunoglobulin | 0.0003767 | Direct |
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.0005462 | Direct |
50044,50044 50044 - SH3-domain 50044 - SH3-domain | 0.0007086 | Direct |
49562,49562 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.01997 | Inherited |
56968,48431 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions 48431 - Lipovitellin-phosvitin complex, superhelical domain | 0.02756 | Inherited |
47473,47473 47473 - EF-hand 47473 - EF-hand | 0.02756 | Inherited |
48431,56968 48431 - Lipovitellin-phosvitin complex, superhelical domain 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.02756 | Inherited |
81660,56784 81660 - Metal cation-transporting ATPase, ATP-binding domain N 56784 - HAD-like | 0.03253 | Inherited |
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat | 0.05273 | Inherited |
50978,50978 50978 - WD40 repeat-like 50978 - WD40 repeat-like | 0.05273 | Inherited |
56784,81665 56784 - HAD-like 81665 - Calcium ATPase, transmembrane domain M | 0.05338 | Inherited |
57889,57889 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain | 0.165 | Inherited |
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like | 0.2105 | Inherited |
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0.2105 | Inherited |
52490,55307 52490 - Tubulin nucleotide-binding domain-like 55307 - Tubulin C-terminal domain-like | 0.244 | Inherited |
90123,52540 90123 - ABC transporter transmembrane region 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.6035 | Inherited |
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like | 0.7359 | Inherited |
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain | 0.9377 | Inherited |
(show details)
Supra-domains annotated to this WP term (SPWP level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
74788,75632,46785 74788 - Cullin repeat-like 75632 - Cullin homology domain 46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
52540,52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0003767 | DIRECT |
56968,48431,56968 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions 48431 - Lipovitellin-phosvitin complex, superhelical domain 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.02756 | INHERITED FROM: unfolded protein response variant |
81660,56784,81665 81660 - Metal cation-transporting ATPase, ATP-binding domain N 56784 - HAD-like 81665 - Calcium ATPase, transmembrane domain M | 0.05338 | INHERITED FROM: nicotine hypersensitive |
46966,46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat 46966 - Spectrin repeat | 0.1003 | INHERITED FROM: drug response variant || drug resistant |
48592,54849,52029 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0.2105 | INHERITED FROM: unfolded protein response variant |
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
74788,75632,46785 74788 - Cullin repeat-like 75632 - Cullin homology domain 46785 - "Winged helix" DNA-binding domain | 0 | Direct |
52540,52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0003767 | Direct |
56968,48431,56968 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions 48431 - Lipovitellin-phosvitin complex, superhelical domain 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.02756 | Inherited |
81660,56784,81665 81660 - Metal cation-transporting ATPase, ATP-binding domain N 56784 - HAD-like 81665 - Calcium ATPase, transmembrane domain M | 0.05338 | Inherited |
46966,46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat 46966 - Spectrin repeat | 0.1003 | Inherited |
48592,54849,52029 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0.2105 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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