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Worm Phenotype (WP): chemical response variant

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Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   Variant [WBPhenotype:0000886] <2>
+ + + + 4:   physiology variant [WBPhenotype:0000519] <14>(510|587) (510|248|68)
+ + + 3:   organism physiology variant [WBPhenotype:0000576] <9>(369|431) (372|193|56)
+ + 2:   organism homeostasis metabolism variant [WBPhenotype:0000577] <16>(361|421) (363|190|55)
+ 1:   organism environmental stimulus response variant [WBPhenotype:0000738] <15>(138|128) (139|57|18)
0:   chemical response variant [WBPhenotype:0000523] <17>(80|73) (81|30|9)
- 1:   chemical hypersensitive [WBPhenotype:0001918] <43>(20|24) (20|12|3)
- 1:   chemical resistant [WBPhenotype:0001502] <38>(17|15) (17|5|1)
- 1:   drug response variant [WBPhenotype:0000631] <27>(49|43) (50|15|2)
- 1:   chemosensory response variant [WBPhenotype:0001040] <3>(20|19) (20|5|0)
- 1:   organism toxic chemical response variant [WBPhenotype:0001379] <3>(6|7) (6|2|0)
- 1:   response to food variant [WBPhenotype:0001072] <3>(2|2) (2|0|0)
- 1:   manganese response variant [WBPhenotype:0001863] <2>(1|1) (1|0|0)
- 1:   bis phenol A response variant [WBPhenotype:0000931] <1>(0|0) (0|0|0)
- 1:   cellular oxidative stress response variant [WBPhenotype:0000068] <1>(0|0) (0|0|0)
- 1:   lead response variant [WBPhenotype:0002227] <1>(0|0) (0|0|0)
- 1:   organism desiccation response variant [WBPhenotype:0001417] <1>(0|0) (0|0|0)
- 1:   aluminum response variant [WBPhenotype:0002228](0|0) (0|0|0)
- 1:   growth inhibition response to chemical [WBPhenotype:0002125](0|0) (0|0|0)
- 1:   high pH avoidance defective [WBPhenotype:0002385](0|0) (0|0|0)
- 1:   neurotransmitter response variant [WBPhenotype:0002399](0|0) (0|0|0)
- 1:   selenium response variant [WBPhenotype:0002256](2|2) (2|1|0)
- 1:   unfolded protein response variant [WBPhenotype:0001719](6|5) (6|4|2)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Transducin (heterotrimeric G protein), gamma chain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Skp1 dimerisation domain-like0.00000000002208Direct
Nicotinic receptor ligand binding domain-like0.0000000003902Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0000000006707Direct
Cullin repeat-like0.00000005515Direct
Protein kinase-like (PK-like)0.0000001634Direct
Cullin homology domain0.000002838Direct
Transducin (alpha subunit), insertion domain0.000016Direct
Nucleotide cyclase0.0000186Direct
cAMP-binding domain-like0.00005029Direct
Ligand-binding domain in the NO signalling and Golgi transport0.0002063Direct
ABC transporter transmembrane region0.0007162Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0.0007667Direct
Periplasmic binding protein-like I0.005545Inherited
Cation efflux protein transmembrane domain-like0.006722Inherited
t-snare proteins0.008616Inherited
Myosin rod fragments0.008616Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.009642Inherited
Cation efflux protein cytoplasmic domain-like0.009642Inherited
EF-hand0.01717Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.04682Inherited
PRTase-like0.0492Inherited
Lipovitellin-phosvitin complex, superhelical domain0.06109Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.06109Inherited
Spectrin repeat0.06109Inherited
ENTH/VHS domain0.06276Inherited
TPR-like0.07014Inherited
Voltage-gated potassium channels0.07934Inherited
Periplasmic binding protein-like II0.08303Inherited
Immunoglobulin0.08779Inherited
Cytochrome P4500.08779Inherited
Calcium ATPase, transmembrane domain M0.09099Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.09099Inherited
Calcium ATPase, transduction domain A0.09099Inherited
Troponin coil-coiled subunits0.1022Inherited
SH3-domain0.1112Inherited
Regulator of G-protein signaling, RGS0.1267Inherited
SAM/Pointed domain0.1267Inherited
Multidrug efflux transporter AcrB transmembrane domain0.1321Inherited
PDZ domain-like0.1371Inherited
WD40 repeat-like0.1504Inherited
Cysteine-rich domain0.1684Inherited
PYP-like sensor domain (PAS domain)0.1701Inherited
SNARE-like0.1882Inherited
PH domain-like0.1967Inherited
EGF/Laminin0.2372Inherited
Glutathione synthetase ATP-binding domain-like0.2424Inherited
"Winged helix" DNA-binding domain0.2549Inherited
SNF-like0.2791Inherited
HMG-box0.2791Inherited
HAD-like0.3027Inherited
Cystine-knot cytokines0.3365Inherited
P-loop containing nucleoside triphosphate hydrolases0.3526Inherited
GroEL-intermediate domain like0.3575Inherited
GroEL equatorial domain-like0.3575Inherited
WW domain0.3575Inherited
Lipocalins0.3575Inherited
GroEL apical domain-like0.3575Inherited
FAD/NAD(P)-binding domain0.3843Inherited
Bromodomain0.4737Inherited
Homeodomain-like0.4802Inherited
Cysteine proteinases0.4837Inherited
HSP20-like chaperones0.5684Inherited
Tubulin nucleotide-binding domain-like0.5684Inherited
DBL homology domain (DH-domain)0.5998Inherited
Thioredoxin-like0.6485Inherited
Leucine zipper domain0.7015Inherited
Tubulin C-terminal domain-like0.7015Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.841Inherited
GST C-terminal domain-like0.8925Inherited
HLH, helix-loop-helix DNA-binding domain0.8967Inherited
Sm-like ribonucleoproteins0.9659Inherited
Ankyrin repeat1Inherited
beta-beta-alpha zinc fingers1Inherited
Nucleotidylyl transferase1Inherited
Family A G protein-coupled receptor-like1Inherited
Nucleic acid-binding proteins1Inherited
Nuclear receptor ligand-binding domain1Inherited
MFS general substrate transporter1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Cullin repeat0Direct
Quinoprotein alcohol dehydrogenase-like0Direct
SCF ubiquitin ligase complex WHB domain0Direct
Transducin (heterotrimeric G protein), gamma chain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Nicotinic receptor ligand binding domain-like0.000000001038Direct
Neurotransmitter-gated ion-channel transmembrane pore0.000000001038Direct
Skp1 dimerisation domain-like0.000000001677Direct
Protein kinases, catalytic subunit0.000001132Direct
Cullin homology domain0.000007587Direct
Transducin (alpha subunit), insertion domain0.00001676Direct
Adenylyl and guanylyl cyclase catalytic domain0.00002047Direct
cAMP-binding domain0.00007263Direct
ABC transporter transmembrane region0.00118Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.001271Inherited
H-NOX domain0.001493Inherited
Eps15 homology domain (EH domain)0.001493Inherited
BTB/POZ domain0.00547Inherited
Transforming growth factor (TGF)-beta0.00606Inherited
Cation efflux protein cytoplasmic domain-like0.00606Inherited
PLC-like (P variant)0.01166Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.01501Inherited
t-snare proteins0.01519Inherited
L-arabinose binding protein-like0.01619Inherited
Cation efflux protein transmembrane domain-like0.02551Inherited
G proteins0.0261Inherited
Phosphoribosyltransferases (PRTases)0.02925Inherited
Clathrin coat assembly domain0.02925Inherited
I set domains0.03294Inherited
Synaptotagmin-like (S variant)0.03376Inherited
ABC transporter ATPase domain-like0.04774Inherited
FAD/NAD-linked reductases, N-terminal and central domains0.05706Inherited
Lipovitellin-phosvitin complex, superhelical domain0.05706Inherited
Spectrin repeat0.05706Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.05706Inherited
Pyridoxal-dependent decarboxylase0.05706Inherited
Multidrug efflux transporter AcrB transmembrane domain0.06154Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.07787Inherited
Phosphate binding protein-like0.07957Inherited
Calcium ATPase, transduction domain A0.08871Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.08871Inherited
PDZ domain0.08871Inherited
SH3-domain0.1138Inherited
Pleckstrin-homology domain (PH domain)0.1138Inherited
Regulator of G-protein signaling, RGS0.1213Inherited
Glutathione peroxidase-like0.1303Inherited
Group II chaperonin (CCT, TRIC), intermediate domain0.1602Inherited
Meta-cation ATPase, catalytic domain P0.1834Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.2398Inherited
Cytochrome P4500.2432Inherited
Erythroid transcription factor GATA-10.2699Inherited
SNF-like0.2699Inherited
HMG-box0.2699Inherited
WD40-repeat0.2927Inherited
Calcium ATPase, transmembrane domain M0.3515Inherited
Voltage-gated potassium channels0.4502Inherited
Group II chaperonin (CCT, TRIC), apical domain0.4659Inherited
Bromodomain0.4659Inherited
Group II chaperonin (CCT, TRIC), ATPase domain0.4659Inherited
Tubulin, GTPase domain0.5641Inherited
Fatty acid binding protein-like0.5995Inherited
DBL homology domain (DH-domain)0.6006Inherited
Homeodomain0.6888Inherited
Leucine zipper domain0.7016Inherited
Tubulin, C-terminal domain0.7016Inherited
Glutathione S-transferase (GST), N-terminal domain0.738Inherited
HLH, helix-loop-helix DNA-binding domain0.8947Inherited
Glutathione S-transferase (GST), C-terminal domain0.9225Inherited
Rhodopsin-like0.9496Inherited
Nuclear receptor1Inherited
Ankyrin repeat1Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain1Inherited
Nuclear receptor ligand-binding domain1Inherited


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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Transducin (heterotrimeric G protein), gamma chain0Direct
Skp1 dimerisation domain-like0.00000000001744Direct
Nicotinic receptor ligand binding domain-like0.0000000003094Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0000000005323Direct
Cullin repeat-like0.00000004414Direct
Protein kinase-like (PK-like)0.0000001311Direct
Cullin homology domain0.000002302Direct
Transducin (alpha subunit), insertion domain0.00001303Direct
Nucleotide cyclase0.00001516Direct
cAMP-binding domain-like0.00004114Direct
Ligand-binding domain in the NO signalling and Golgi transport0.0001695Direct
ABC transporter transmembrane region0.0005945Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0.0006373Direct
Periplasmic binding protein-like I0.004716Inherited
Cation efflux protein transmembrane domain-like0.005733Inherited
t-snare proteins0.007388Inherited
Myosin rod fragments0.007388Inherited
Cation efflux protein cytoplasmic domain-like0.008285Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.008285Inherited
EF-hand0.01491Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.04142Inherited
PRTase-like0.04359Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.0544Inherited
Lipovitellin-phosvitin complex, superhelical domain0.0544Inherited
Spectrin repeat0.0544Inherited
ENTH/VHS domain0.05592Inherited
TPR-like0.0627Inherited
Voltage-gated potassium channels0.07115Inherited
Periplasmic binding protein-like II0.07457Inherited
Immunoglobulin0.07895Inherited
Cytochrome P4500.07895Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.0819Inherited
Calcium ATPase, transmembrane domain M0.0819Inherited
Calcium ATPase, transduction domain A0.0819Inherited
Troponin coil-coiled subunits0.09237Inherited
SH3-domain0.1007Inherited
SAM/Pointed domain0.1151Inherited
Regulator of G-protein signaling, RGS0.1151Inherited
Multidrug efflux transporter AcrB transmembrane domain0.1201Inherited
PDZ domain-like0.1249Inherited
WD40 repeat-like0.1372Inherited
Cysteine-rich domain0.1543Inherited
PYP-like sensor domain (PAS domain)0.1559Inherited
SNARE-like0.173Inherited
PH domain-like0.181Inherited
EGF/Laminin0.2197Inherited
SMAD/FHA domain0.2249Inherited
Glutathione synthetase ATP-binding domain-like0.2249Inherited
"Winged helix" DNA-binding domain0.237Inherited
HMG-box0.2605Inherited
SNF-like0.2605Inherited
HAD-like0.2835Inherited
Cystine-knot cytokines0.3167Inherited
P-loop containing nucleoside triphosphate hydrolases0.3325Inherited
GroEL equatorial domain-like0.3373Inherited
WW domain0.3373Inherited
GroEL apical domain-like0.3373Inherited
GroEL-intermediate domain like0.3373Inherited
Lipocalins0.3373Inherited
FAD/NAD(P)-binding domain0.3638Inherited
Bromodomain0.4523Inherited
Homeodomain-like0.4589Inherited
Cysteine proteinases0.4621Inherited
HSP20-like chaperones0.5467Inherited
Tubulin nucleotide-binding domain-like0.5467Inherited
DBL homology domain (DH-domain)0.578Inherited
Thioredoxin-like0.6269Inherited
Tubulin C-terminal domain-like0.6809Inherited
Leucine zipper domain0.6809Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.8237Inherited
GST C-terminal domain-like0.877Inherited
HLH, helix-loop-helix DNA-binding domain0.8814Inherited
Sm-like ribonucleoproteins0.9533Inherited
MFS general substrate transporter1Inherited
Nuclear receptor ligand-binding domain1Inherited
Ankyrin repeat1Inherited
Nucleic acid-binding proteins1Inherited
Nucleotidylyl transferase1Inherited
Family A G protein-coupled receptor-like1Inherited
beta-beta-alpha zinc fingers1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.0000000005323Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.0000000006158Direct
    56112,55073
  • 56112 - Protein kinase-like (PK-like)
  • 55073 - Nucleotide cyclase
  • 0.0000009828Direct
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00001303Direct
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0005945Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.0007896Direct
    52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0.0008335Direct
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.001189Inherited
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.001696Inherited
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0.008285Inherited
    161111,160240
  • 161111 - Cation efflux protein transmembrane domain-like
  • 160240 - Cation efflux protein cytoplasmic domain-like
  • 0.008285Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.009165Inherited
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0.0544Inherited
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.0544Inherited
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.0544Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.0819Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.09237Inherited
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.09237Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.1201Inherited
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.2605Inherited
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.3373Inherited
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.3373Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.3956Inherited
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.5467Inherited
    56436,49854
  • 56436 - C-type lectin-like
  • 49854 - Spermadhesin, CUB domain
  • 0.6643Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 0.7458Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.9255Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0007896Direct
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0.0008335Direct
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0008335Direct
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.0544Inherited
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.1201Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.1559Inherited
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.3373Inherited
    56436,56436,49854
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 49854 - Spermadhesin, CUB domain
  • 0.4654Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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