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Worm Phenotype (WP): chemical response variant

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   Variant [WBPhenotype:0000886] <2>
+ + + + 4:   physiology variant [WBPhenotype:0000519] <14>(510|587) (510|248|69)
+ + + 3:   organism physiology variant [WBPhenotype:0000576] <9>(369|431) (372|193|57)
+ + 2:   organism homeostasis metabolism variant [WBPhenotype:0000577] <16>(361|421) (363|190|56)
+ 1:   organism environmental stimulus response variant [WBPhenotype:0000738] <15>(137|128) (138|57|18)
0:   chemical response variant [WBPhenotype:0000523] <17>(79|73) (80|30|9)
- 1:   chemical hypersensitive [WBPhenotype:0001918] <43>(20|24) (20|12|3)
- 1:   chemical resistant [WBPhenotype:0001502] <38>(16|15) (16|5|1)
- 1:   drug response variant [WBPhenotype:0000631] <27>(48|43) (49|15|2)
- 1:   chemosensory response variant [WBPhenotype:0001040] <3>(20|19) (20|5|0)
- 1:   organism toxic chemical response variant [WBPhenotype:0001379] <3>(6|7) (6|2|0)
- 1:   response to food variant [WBPhenotype:0001072] <3>(2|2) (2|0|0)
- 1:   manganese response variant [WBPhenotype:0001863] <2>(1|1) (1|0|0)
- 1:   bis phenol A response variant [WBPhenotype:0000931] <1>(0|0) (0|0|0)
- 1:   cellular oxidative stress response variant [WBPhenotype:0000068] <1>(0|0) (0|0|0)
- 1:   lead response variant [WBPhenotype:0002227] <1>(0|0) (0|0|0)
- 1:   organism desiccation response variant [WBPhenotype:0001417] <1>(0|0) (0|0|0)
- 1:   aluminum response variant [WBPhenotype:0002228](0|0) (0|0|0)
- 1:   growth inhibition response to chemical [WBPhenotype:0002125](0|0) (0|0|0)
- 1:   high pH avoidance defective [WBPhenotype:0002385](0|0) (0|0|0)
- 1:   neurotransmitter response variant [WBPhenotype:0002399](0|0) (0|0|0)
- 1:   selenium response variant [WBPhenotype:0002256](2|2) (2|1|0)
- 1:   unfolded protein response variant [WBPhenotype:0001719](6|5) (6|4|2)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Transducin (heterotrimeric G protein), gamma chain0Direct
Skp1 dimerisation domain-like0.00000000002151Direct
Nicotinic receptor ligand binding domain-like0.0000000003903Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0000000006708Direct
Cullin repeat-like0.00000005437Direct
Protein kinase-like (PK-like)0.0000001635Direct
Cullin homology domain0.000002807Direct
Transducin (alpha subunit), insertion domain0.000016Direct
Nucleotide cyclase0.0000186Direct
cAMP-binding domain-like0.00004963Direct
Ligand-binding domain in the NO signalling and Golgi transport0.0002042Direct
ABC transporter transmembrane region0.0007163Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0.0007668Direct
Periplasmic binding protein-like I0.005545Inherited
Cation efflux protein transmembrane domain-like0.006671Inherited
t-snare proteins0.008563Inherited
Myosin rod fragments0.008563Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.009588Inherited
Cation efflux protein cytoplasmic domain-like0.009588Inherited
EF-hand0.01717Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.04656Inherited
PRTase-like0.04897Inherited
Spectrin repeat0.06109Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.06109Inherited
Lipovitellin-phosvitin complex, superhelical domain0.06109Inherited
ENTH/VHS domain0.0624Inherited
TPR-like0.07017Inherited
Voltage-gated potassium channels0.07936Inherited
Periplasmic binding protein-like II0.08304Inherited
Cytochrome P4500.08784Inherited
Immunoglobulin0.08784Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.09102Inherited
Calcium ATPase, transmembrane domain M0.09102Inherited
Calcium ATPase, transduction domain A0.09102Inherited
Troponin coil-coiled subunits0.1023Inherited
SH3-domain0.1112Inherited
Regulator of G-protein signaling, RGS0.1268Inherited
SAM/Pointed domain0.1268Inherited
Multidrug efflux transporter AcrB transmembrane domain0.1321Inherited
PDZ domain-like0.136Inherited
WD40 repeat-like0.1505Inherited
Cysteine-rich domain0.1683Inherited
PYP-like sensor domain (PAS domain)0.1701Inherited
SNARE-like0.1875Inherited
PH domain-like0.1966Inherited
EGF/Laminin0.2355Inherited
Glutathione synthetase ATP-binding domain-like0.2424Inherited
"Winged helix" DNA-binding domain0.2549Inherited
HMG-box0.2791Inherited
SNF-like0.2791Inherited
HAD-like0.3026Inherited
Cystine-knot cytokines0.3354Inherited
P-loop containing nucleoside triphosphate hydrolases0.3528Inherited
GroEL apical domain-like0.3576Inherited
GroEL equatorial domain-like0.3576Inherited
Lipocalins0.3576Inherited
GroEL-intermediate domain like0.3576Inherited
FAD/NAD(P)-binding domain0.3826Inherited
Bromodomain0.4736Inherited
Homeodomain-like0.4803Inherited
Cysteine proteinases0.4812Inherited
HSP20-like chaperones0.5685Inherited
Tubulin nucleotide-binding domain-like0.5685Inherited
DBL homology domain (DH-domain)0.5997Inherited
Thioredoxin-like0.6486Inherited
Tubulin C-terminal domain-like0.7015Inherited
Leucine zipper domain0.7015Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.8378Inherited
GST C-terminal domain-like0.8924Inherited
HLH, helix-loop-helix DNA-binding domain0.8967Inherited
Sm-like ribonucleoproteins0.966Inherited
Nucleic acid-binding proteins1Inherited
Nucleotidylyl transferase1Inherited
Ankyrin repeat1Inherited
Nuclear receptor ligand-binding domain1Inherited
MFS general substrate transporter1Inherited
beta-beta-alpha zinc fingers1Inherited
Family A G protein-coupled receptor-like1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Transducin (heterotrimeric G protein), gamma chain0Direct
Cullin repeat0Direct
SCF ubiquitin ligase complex WHB domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Quinoprotein alcohol dehydrogenase-like0Direct
Neurotransmitter-gated ion-channel transmembrane pore0.000000001039Direct
Nicotinic receptor ligand binding domain-like0.000000001039Direct
Skp1 dimerisation domain-like0.00000000164Direct
Protein kinases, catalytic subunit0.000001196Direct
Cullin homology domain0.000007512Direct
Transducin (alpha subunit), insertion domain0.00001676Direct
Adenylyl and guanylyl cyclase catalytic domain0.00002048Direct
cAMP-binding domain0.00007178Direct
ABC transporter transmembrane region0.00118Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.001263Inherited
H-NOX domain0.001485Inherited
Eps15 homology domain (EH domain)0.001485Inherited
BTB/POZ domain0.005384Inherited
Transforming growth factor (TGF)-beta0.00603Inherited
Cation efflux protein cytoplasmic domain-like0.00603Inherited
PLC-like (P variant)0.01166Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.01493Inherited
t-snare proteins0.0151Inherited
L-arabinose binding protein-like0.01619Inherited
Cation efflux protein transmembrane domain-like0.02536Inherited
G proteins0.0261Inherited
Phosphoribosyltransferases (PRTases)0.0291Inherited
Clathrin coat assembly domain0.0291Inherited
I set domains0.03295Inherited
Synaptotagmin-like (S variant)0.03377Inherited
ABC transporter ATPase domain-like0.04775Inherited
Pyridoxal-dependent decarboxylase0.0571Inherited
Lipovitellin-phosvitin complex, superhelical domain0.0571Inherited
Spectrin repeat0.0571Inherited
FAD/NAD-linked reductases, N-terminal and central domains0.0571Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.0571Inherited
Multidrug efflux transporter AcrB transmembrane domain0.06112Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.07752Inherited
Phosphate binding protein-like0.07959Inherited
Calcium ATPase, transduction domain A0.08874Inherited
PDZ domain0.08874Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.08874Inherited
Pleckstrin-homology domain (PH domain)0.1139Inherited
SH3-domain0.1139Inherited
Regulator of G-protein signaling, RGS0.1214Inherited
Glutathione peroxidase-like0.1296Inherited
Group II chaperonin (CCT, TRIC), intermediate domain0.1602Inherited
Meta-cation ATPase, catalytic domain P0.1835Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.2399Inherited
Cytochrome P4500.2413Inherited
HMG-box0.27Inherited
SNF-like0.27Inherited
Erythroid transcription factor GATA-10.27Inherited
WD40-repeat0.2927Inherited
Calcium ATPase, transmembrane domain M0.3516Inherited
Voltage-gated potassium channels0.4486Inherited
Group II chaperonin (CCT, TRIC), ATPase domain0.4659Inherited
Bromodomain0.4659Inherited
Group II chaperonin (CCT, TRIC), apical domain0.4659Inherited
Tubulin, GTPase domain0.5642Inherited
Fatty acid binding protein-like0.5995Inherited
DBL homology domain (DH-domain)0.6005Inherited
Homeodomain0.6888Inherited
Tubulin, C-terminal domain0.7014Inherited
Leucine zipper domain0.7014Inherited
Glutathione S-transferase (GST), N-terminal domain0.738Inherited
HLH, helix-loop-helix DNA-binding domain0.8949Inherited
Glutathione S-transferase (GST), C-terminal domain0.9226Inherited
Rhodopsin-like0.9479Inherited
Ankyrin repeat1Inherited
Nuclear receptor1Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain1Inherited
Nuclear receptor ligand-binding domain1Inherited


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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Transducin (heterotrimeric G protein), gamma chain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Skp1 dimerisation domain-like0.00000000001698Direct
Nicotinic receptor ligand binding domain-like0.0000000003093Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0000000005321Direct
Cullin repeat-like0.00000004349Direct
Protein kinase-like (PK-like)0.0000001311Direct
Cullin homology domain0.000002275Direct
Transducin (alpha subunit), insertion domain0.00001303Direct
Nucleotide cyclase0.00001516Direct
cAMP-binding domain-like0.00004059Direct
Ligand-binding domain in the NO signalling and Golgi transport0.0001677Direct
ABC transporter transmembrane region0.0005944Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0.0006371Direct
Periplasmic binding protein-like I0.004716Inherited
Cation efflux protein transmembrane domain-like0.005688Inherited
t-snare proteins0.007339Inherited
Myosin rod fragments0.007339Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.008236Inherited
Cation efflux protein cytoplasmic domain-like0.008236Inherited
EF-hand0.0149Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.04117Inherited
PRTase-like0.04337Inherited
Spectrin repeat0.0544Inherited
Lipovitellin-phosvitin complex, superhelical domain0.0544Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.0544Inherited
ENTH/VHS domain0.0556Inherited
TPR-like0.06271Inherited
Voltage-gated potassium channels0.07117Inherited
Periplasmic binding protein-like II0.07458Inherited
Immunoglobulin0.07898Inherited
Cytochrome P4500.07898Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.08193Inherited
Calcium ATPase, transduction domain A0.08193Inherited
Calcium ATPase, transmembrane domain M0.08193Inherited
Troponin coil-coiled subunits0.0924Inherited
SH3-domain0.1007Inherited
Regulator of G-protein signaling, RGS0.1152Inherited
SAM/Pointed domain0.1152Inherited
Multidrug efflux transporter AcrB transmembrane domain0.1201Inherited
PDZ domain-like0.1238Inherited
WD40 repeat-like0.1373Inherited
Cysteine-rich domain0.1542Inherited
PYP-like sensor domain (PAS domain)0.1559Inherited
SNARE-like0.1723Inherited
PH domain-like0.181Inherited
EGF/Laminin0.2181Inherited
SMAD/FHA domain0.2249Inherited
Glutathione synthetase ATP-binding domain-like0.2249Inherited
"Winged helix" DNA-binding domain0.237Inherited
HMG-box0.2605Inherited
SNF-like0.2605Inherited
HAD-like0.2834Inherited
Cystine-knot cytokines0.3157Inherited
P-loop containing nucleoside triphosphate hydrolases0.3326Inherited
GroEL equatorial domain-like0.3373Inherited
Lipocalins0.3373Inherited
GroEL apical domain-like0.3373Inherited
GroEL-intermediate domain like0.3373Inherited
FAD/NAD(P)-binding domain0.3621Inherited
Bromodomain0.4523Inherited
Homeodomain-like0.4588Inherited
Cysteine proteinases0.4598Inherited
Tubulin nucleotide-binding domain-like0.5467Inherited
HSP20-like chaperones0.5467Inherited
DBL homology domain (DH-domain)0.578Inherited
Thioredoxin-like0.6269Inherited
Leucine zipper domain0.6808Inherited
Tubulin C-terminal domain-like0.6808Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.8202Inherited
GST C-terminal domain-like0.877Inherited
HLH, helix-loop-helix DNA-binding domain0.8815Inherited
Sm-like ribonucleoproteins0.9535Inherited
Ankyrin repeat1Inherited
Nucleic acid-binding proteins1Inherited
beta-beta-alpha zinc fingers1Inherited
Family A G protein-coupled receptor-like1Inherited
Nuclear receptor ligand-binding domain1Inherited
MFS general substrate transporter1Inherited
Nucleotidylyl transferase1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.0000000005321Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.0000000006013Direct
    56112,55073
  • 56112 - Protein kinase-like (PK-like)
  • 55073 - Nucleotide cyclase
  • 0.0000009638Direct
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00001303Direct
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0005944Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.0007844Direct
    52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0.0008261Direct
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.001189Inherited
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.001683Inherited
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0.008236Inherited
    161111,160240
  • 161111 - Cation efflux protein transmembrane domain-like
  • 160240 - Cation efflux protein cytoplasmic domain-like
  • 0.008236Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.009093Inherited
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.0544Inherited
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.0544Inherited
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0.0544Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.08193Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.0924Inherited
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.0924Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.1201Inherited
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.2605Inherited
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.3373Inherited
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.3373Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.3957Inherited
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.5467Inherited
    56436,49854
  • 56436 - C-type lectin-like
  • 49854 - Spermadhesin, CUB domain
  • 0.6629Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 0.7458Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.9242Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0007844Direct
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0008261Direct
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0.0008261Direct
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.0544Inherited
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.1201Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.1559Inherited
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.3373Inherited
    56436,56436,49854
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 49854 - Spermadhesin, CUB domain
  • 0.4643Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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