Worm Phenotype (WP): chemical response variant

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

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Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + + + + 5: Variant [WBPhenotype:0000886] <5>

+ + + + 4: physiology variant [WBPhenotype:0000519] <7> (494|573) (495|248|68)

+ + + 3: organism physiology variant [WBPhenotype:0000576] <10> (354|423) (357|200|60)

+ + 2: organism homeostasis metabolism variant [WBPhenotype:0000577] <17> (343|412) (348|198|59)

+ 1: organism environmental stimulus response variant [WBPhenotype:0000738] <16> (115|108) (120|53|16)

0: chemical response variant [WBPhenotype:0000523] <11> (66|58) (68|26|6)

- 1: drug response variant [WBPhenotype:0000631] <27> (42|37) (44|17|2)

- 1: chemical hypersensitive [WBPhenotype:0001918] <5> (7|7) (7|4|1)

- 1: response to food variant [WBPhenotype:0001072] <4> (2|2) (2|0|0)

- 1: chemosensory response variant [WBPhenotype:0001040] <3> (21|20) (21|5|0)

- 1: chemical resistant [WBPhenotype:0001502] <2> (0|0) (0|0|0)

- 1: bis phenol A response variant [WBPhenotype:0000931] <1> (0|0) (0|0|0)

- 1: organism toxic chemical response variant [WBPhenotype:0001379] <1> (0|0) (0|0|0)

- 1: growth inhibition response to chemical [WBPhenotype:0002125] (0|0) (0|0|0)

- 1: high pH avoidance defective [WBPhenotype:0002385] (0|0) (0|0|0)

- 1: neurotransmitter response variant [WBPhenotype:0002399] (0|0) (0|0|0)

- 1: unfolded protein response variant [WBPhenotype:0001719] (6|5) (6|4|2)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
Transducin (heterotrimeric G protein), gamma chain	0	Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	Direct
Skp1 dimerisation domain-like	0.0000000000004616	Direct
Nicotinic receptor ligand binding domain-like	0.00000000002537	Direct
Neurotransmitter-gated ion-channel transmembrane pore	0.00000000004687	Direct
Cullin repeat-like	0.000000006827	Direct
Cullin homology domain	0.0000005714	Direct
Protein kinase-like (PK-like)	0.000003831	Direct
C2 domain (Calcium/lipid-binding domain, CaLB)	0.00003875	Direct
cAMP-binding domain-like	0.00008904	Direct
Periplasmic binding protein-like II	0.0001689	Direct
Periplasmic binding protein-like I	0.0002902	Direct
Myosin rod fragments	0.003213	Inherited
Transducin (alpha subunit), insertion domain	0.00353	Inherited
Quinoprotein alcohol dehydrogenase-like	0.006277	Inherited
SH2 domain	0.01792	Inherited
Voltage-gated potassium channels	0.01872	Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes	0.01958	Inherited
Cysteine-rich domain	0.02175	Inherited
PRTase-like	0.02366	Inherited
TPR-like	0.02447	Inherited
ENTH/VHS domain	0.0269	Inherited
PDZ domain-like	0.03139	Inherited
Multidrug efflux transporter AcrB transmembrane domain	0.03213	Inherited
Spectrin repeat	0.04192	Inherited
Immunoglobulin	0.0436	Inherited
Metal cation-transporting ATPase, ATP-binding domain N	0.05467	Inherited
Calcium ATPase, transduction domain A	0.05467	Inherited
Calcium ATPase, transmembrane domain M	0.05467	Inherited
Troponin coil-coiled subunits	0.07532	Inherited
Glutathione synthetase ATP-binding domain-like	0.08455	Inherited
SMAD/FHA domain	0.08455	Inherited
Regulator of G-protein signaling, RGS	0.08676	Inherited
SAM/Pointed domain	0.08676	Inherited
WD40 repeat-like	0.09708	Inherited
SH3-domain	0.1072	Inherited
Nucleotide cyclase	0.1076	Inherited
EGF/Laminin	0.1215	Inherited
t-snare proteins	0.1337	Inherited
SNARE-like	0.1337	Inherited
Cystine-knot cytokines	0.2021	Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions	0.2184	Inherited
Lipovitellin-phosvitin complex, superhelical domain	0.2184	Inherited
POZ domain	0.2227	Inherited
PH domain-like	0.271	Inherited
GroEL-intermediate domain like	0.2783	Inherited
GroEL apical domain-like	0.2783	Inherited
GroEL equatorial domain-like	0.2783	Inherited
Tubulin nucleotide-binding domain-like	0.3229	Inherited
Sm-like ribonucleoproteins	0.3326	Inherited
HAD-like	0.3508	Inherited
P-loop containing nucleoside triphosphate hydrolases	0.3901	Inherited
Tubulin C-terminal domain-like	0.4631	Inherited
"Winged helix" DNA-binding domain	0.5391	Inherited
Glucocorticoid receptor-like (DNA-binding domain)	0.5836	Inherited
Bromodomain	0.7003	Inherited
ABC transporter transmembrane region	0.7254	Inherited
Homeodomain-like	0.8097	Inherited
Nucleic acid-binding proteins	0.883	Inherited
DBL homology domain (DH-domain)	0.9012	Inherited
Leucine zipper domain	0.9109	Inherited
HLH, helix-loop-helix DNA-binding domain	0.9628	Inherited
Nuclear receptor ligand-binding domain	0.9938	Inherited
beta-beta-alpha zinc fingers	1	Inherited
Family A G protein-coupled receptor-like	1	Inherited
Ankyrin repeat	1	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
Cullin repeat	0	Direct
Transducin (heterotrimeric G protein), gamma chain	0	Direct
Quinoprotein alcohol dehydrogenase-like	0	Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	Direct
SCF ubiquitin ligase complex WHB domain	0	Direct
Skp1 dimerisation domain-like	0.00000000006319	Direct
Nicotinic receptor ligand binding domain-like	0.00000000009642	Direct
Neurotransmitter-gated ion-channel transmembrane pore	0.00000000009642	Direct
Protein kinases, catalytic subunit	0.0000007455	Direct
Cullin homology domain	0.000001764	Direct
cAMP-binding domain	0.0001459	Direct
Phosphate binding protein-like	0.0001459	Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain	0.0004768	Direct
BTB/POZ domain	0.0009023	Direct
Transforming growth factor (TGF)-beta	0.00281	Inherited
Transducin (alpha subunit), insertion domain	0.003914	Inherited
L-arabinose binding protein-like	0.003914	Inherited
Synaptotagmin-like (S variant)	0.005294	Inherited
PLC-like (P variant)	0.006831	Inherited
Clathrin coat assembly domain	0.01439	Inherited
Phosphoribosyltransferases (PRTases)	0.01439	Inherited
I set domains	0.01929	Inherited
Multidrug efflux transporter AcrB transmembrane domain	0.03218	Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)	0.03218	Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes	0.03628	Inherited
Spectrin repeat	0.04031	Inherited
PDZ domain	0.05562	Inherited
Calcium ATPase, transduction domain A	0.05562	Inherited
Metal cation-transporting ATPase, ATP-binding domain N	0.05562	Inherited
Pleckstrin-homology domain (PH domain)	0.06048	Inherited
G proteins	0.07915	Inherited
Regulator of G-protein signaling, RGS	0.08585	Inherited
SH3-domain	0.1148	Inherited
Adenylyl and guanylyl cyclase catalytic domain	0.1179	Inherited
t-snare proteins	0.1283	Inherited
Group II chaperonin (CCT, TRIC), intermediate domain	0.1283	Inherited
Meta-cation ATPase, catalytic domain P	0.1294	Inherited
Voltage-gated potassium channels	0.1648	Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions	0.2157	Inherited
Lipovitellin-phosvitin complex, superhelical domain	0.2157	Inherited
Pyridoxal-dependent decarboxylase	0.2157	Inherited
Calcium ATPase, transmembrane domain M	0.2787	Inherited
Tubulin, GTPase domain	0.3276	Inherited
FYVE, a phosphatidylinositol-3-phosphate binding domain	0.3287	Inherited
WD40-repeat	0.3345	Inherited
Group II chaperonin (CCT, TRIC), ATPase domain	0.392	Inherited
Group II chaperonin (CCT, TRIC), apical domain	0.392	Inherited
Tubulin, C-terminal domain	0.4702	Inherited
Bromodomain	0.7043	Inherited
Rhodopsin-like	0.7687	Inherited
ABC transporter transmembrane region	0.8264	Inherited
ABC transporter ATPase domain-like	0.8295	Inherited
DBL homology domain (DH-domain)	0.9099	Inherited
Leucine zipper domain	0.9177	Inherited
HLH, helix-loop-helix DNA-binding domain	0.9707	Inherited
Nuclear receptor	1	Inherited
Ankyrin repeat	1	Inherited
Nuclear receptor ligand-binding domain	1	Inherited

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Transducin (heterotrimeric G protein), gamma chain	0	Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	Direct
Skp1 dimerisation domain-like	0.0000000000003598	Direct
Nicotinic receptor ligand binding domain-like	0.00000000001989	Direct
Neurotransmitter-gated ion-channel transmembrane pore	0.00000000003676	Direct
Cullin repeat-like	0.000000005402	Direct
Cullin homology domain	0.0000004574	Direct
Protein kinase-like (PK-like)	0.000003089	Direct
C2 domain (Calcium/lipid-binding domain, CaLB)	0.00003148	Direct
cAMP-binding domain-like	0.00007254	Direct
Periplasmic binding protein-like II	0.0001378	Direct
Periplasmic binding protein-like I	0.0002377	Direct
Myosin rod fragments	0.0027	Inherited
Transducin (alpha subunit), insertion domain	0.00297	Inherited
Quinoprotein alcohol dehydrogenase-like	0.005313	Inherited
SH2 domain	0.01545	Inherited
Voltage-gated potassium channels	0.01616	Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes	0.01692	Inherited
Cysteine-rich domain	0.01886	Inherited
PRTase-like	0.02055	Inherited
TPR-like	0.02127	Inherited
ENTH/VHS domain	0.02344	Inherited
PDZ domain-like	0.02745	Inherited
Multidrug efflux transporter AcrB transmembrane domain	0.0281	Inherited
Spectrin repeat	0.03684	Inherited
Immunoglobulin	0.03834	Inherited
Calcium ATPase, transduction domain A	0.04837	Inherited
Calcium ATPase, transmembrane domain M	0.04837	Inherited
Metal cation-transporting ATPase, ATP-binding domain N	0.04837	Inherited
Troponin coil-coiled subunits	0.06723	Inherited
Glutathione synthetase ATP-binding domain-like	0.07573	Inherited
SMAD/FHA domain	0.07573	Inherited
SAM/Pointed domain	0.07778	Inherited
Regulator of G-protein signaling, RGS	0.07778	Inherited
WD40 repeat-like	0.08734	Inherited
SH3-domain	0.0967	Inherited
Nucleotide cyclase	0.09713	Inherited
EGF/Laminin	0.11	Inherited
t-snare proteins	0.1214	Inherited
SNARE-like	0.1214	Inherited
Cystine-knot cytokines	0.1857	Inherited
Lipovitellin-phosvitin complex, superhelical domain	0.2014	Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions	0.2014	Inherited
POZ domain	0.2055	Inherited
PH domain-like	0.2521	Inherited
GroEL equatorial domain-like	0.2591	Inherited
WW domain	0.2591	Inherited
GroEL-intermediate domain like	0.2591	Inherited
GroEL apical domain-like	0.2591	Inherited
Tubulin nucleotide-binding domain-like	0.303	Inherited
Sm-like ribonucleoproteins	0.3125	Inherited
HAD-like	0.3302	Inherited
Insulin-like	0.3378	Inherited
P-loop containing nucleoside triphosphate hydrolases	0.369	Inherited
Tubulin C-terminal domain-like	0.4412	Inherited
"Winged helix" DNA-binding domain	0.5166	Inherited
Glucocorticoid receptor-like (DNA-binding domain)	0.5612	Inherited
Bromodomain	0.6796	Inherited
ABC transporter transmembrane region	0.7053	Inherited
Homeodomain-like	0.792	Inherited
Nucleic acid-binding proteins	0.8679	Inherited
DBL homology domain (DH-domain)	0.8872	Inherited
Leucine zipper domain	0.8973	Inherited
HLH, helix-loop-helix DNA-binding domain	0.9513	Inherited
Nuclear receptor ligand-binding domain	0.9839	Inherited
beta-beta-alpha zinc fingers	1	Inherited
Family A G protein-coupled receptor-like	1	Inherited
Ankyrin repeat	1	Inherited

(show details)

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
74788,75632 74788 - Cullin repeat-like 75632 - Cullin homology domain	0	Direct
75632,46785 75632 - Cullin homology domain 46785 - "Winged helix" DNA-binding domain	0	Direct
54695,81382 54695 - POZ domain 81382 - Skp1 dimerisation domain-like	0.00000000002045	Direct
63712,90112 63712 - Nicotinic receptor ligand binding domain-like 90112 - Neurotransmitter-gated ion-channel transmembrane pore	0.00000000003676	Direct
56112,55073 56112 - Protein kinase-like (PK-like) 55073 - Nucleotide cyclase	0.00000006033	Direct
49265,48726 49265 - Fibronectin type III 48726 - Immunoglobulin	0.0003229	Direct
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III	0.0004092	Direct
50044,50044 50044 - SH3-domain 50044 - SH3-domain	0.0005837	Direct
48452,48452 48452 - TPR-like 48452 - TPR-like	0.0009166	Direct
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0.00297	Inherited
47473,47473 47473 - EF-hand 47473 - EF-hand	0.01171	Inherited
49562,49562 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)	0.01692	Inherited
81660,56784 81660 - Metal cation-transporting ATPase, ATP-binding domain N 56784 - HAD-like	0.04837	Inherited
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat	0.06723	Inherited
50978,50978 50978 - WD40 repeat-like 50978 - WD40 repeat-like	0.06723	Inherited
57889,57889 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain	0.06723	Inherited
56784,81665 56784 - HAD-like 81665 - Calcium ATPase, transmembrane domain M	0.07573	Inherited
48431,56968 48431 - Lipovitellin-phosvitin complex, superhelical domain 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions	0.2014	Inherited
56968,48431 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions 48431 - Lipovitellin-phosvitin complex, superhelical domain	0.2014	Inherited
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like	0.2591	Inherited
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0.2591	Inherited
52490,55307 52490 - Tubulin nucleotide-binding domain-like 55307 - Tubulin C-terminal domain-like	0.303	Inherited
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.4026	Inherited
90123,52540 90123 - ABC transporter transmembrane region 52540 - P-loop containing nucleoside triphosphate hydrolases	0.7053	Inherited
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0.807	Inherited
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain	0.9122	Inherited

(show details)

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
74788,75632,46785 74788 - Cullin repeat-like 75632 - Cullin homology domain 46785 - "Winged helix" DNA-binding domain	0	Direct
52540,52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0.0003229	Direct
81660,56784,81665 81660 - Metal cation-transporting ATPase, ATP-binding domain N 56784 - HAD-like 81665 - Calcium ATPase, transmembrane domain M	0.07573	Inherited
46966,46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat 46966 - Spectrin repeat	0.1214	Inherited
56968,48431,56968 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions 48431 - Lipovitellin-phosvitin complex, superhelical domain 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions	0.2014	Inherited
48592,54849,52029 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0.2591	Inherited

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Worm Phenotype (WP): chemical response variant

Superfamily

Family

Supra-domain (including individual superfamily)