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Worm Phenotype (WP): chemical response variant

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Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   Variant [WBPhenotype:0000886] <5>
+ + + + 4:   physiology variant [WBPhenotype:0000519] <7>(494|573) (495|248|68)
+ + + 3:   organism physiology variant [WBPhenotype:0000576] <10>(354|423) (357|200|60)
+ + 2:   organism homeostasis metabolism variant [WBPhenotype:0000577] <17>(343|412) (348|198|59)
+ 1:   organism environmental stimulus response variant [WBPhenotype:0000738] <16>(115|108) (120|53|16)
0:   chemical response variant [WBPhenotype:0000523] <11>(66|58) (68|26|6)
- 1:   drug response variant [WBPhenotype:0000631] <27>(42|37) (44|17|2)
- 1:   chemical hypersensitive [WBPhenotype:0001918] <5>(7|7) (7|4|1)
- 1:   response to food variant [WBPhenotype:0001072] <4>(2|2) (2|0|0)
- 1:   chemosensory response variant [WBPhenotype:0001040] <3>(21|20) (21|5|0)
- 1:   chemical resistant [WBPhenotype:0001502] <2>(0|0) (0|0|0)
- 1:   bis phenol A response variant [WBPhenotype:0000931] <1>(0|0) (0|0|0)
- 1:   organism toxic chemical response variant [WBPhenotype:0001379] <1>(0|0) (0|0|0)
- 1:   growth inhibition response to chemical [WBPhenotype:0002125](0|0) (0|0|0)
- 1:   high pH avoidance defective [WBPhenotype:0002385](0|0) (0|0|0)
- 1:   neurotransmitter response variant [WBPhenotype:0002399](0|0) (0|0|0)
- 1:   unfolded protein response variant [WBPhenotype:0001719](6|5) (6|4|2)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Transducin (heterotrimeric G protein), gamma chain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Skp1 dimerisation domain-like0.0000000000004616Direct
Nicotinic receptor ligand binding domain-like0.00000000002537Direct
Neurotransmitter-gated ion-channel transmembrane pore0.00000000004687Direct
Cullin repeat-like0.000000006827Direct
Cullin homology domain0.0000005714Direct
Protein kinase-like (PK-like)0.000003831Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0.00003875Direct
cAMP-binding domain-like0.00008904Direct
Periplasmic binding protein-like II0.0001689Direct
Periplasmic binding protein-like I0.0002902Direct
Myosin rod fragments0.003213Inherited
Transducin (alpha subunit), insertion domain0.00353Inherited
Quinoprotein alcohol dehydrogenase-like0.006277Inherited
SH2 domain0.01792Inherited
Voltage-gated potassium channels0.01872Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.01958Inherited
Cysteine-rich domain0.02175Inherited
PRTase-like0.02366Inherited
TPR-like0.02447Inherited
ENTH/VHS domain0.0269Inherited
PDZ domain-like0.03139Inherited
Multidrug efflux transporter AcrB transmembrane domain0.03213Inherited
Spectrin repeat0.04192Inherited
Immunoglobulin0.0436Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.05467Inherited
Calcium ATPase, transduction domain A0.05467Inherited
Calcium ATPase, transmembrane domain M0.05467Inherited
Troponin coil-coiled subunits0.07532Inherited
Glutathione synthetase ATP-binding domain-like0.08455Inherited
SMAD/FHA domain0.08455Inherited
Regulator of G-protein signaling, RGS0.08676Inherited
SAM/Pointed domain0.08676Inherited
WD40 repeat-like0.09708Inherited
SH3-domain0.1072Inherited
Nucleotide cyclase0.1076Inherited
EGF/Laminin0.1215Inherited
t-snare proteins0.1337Inherited
SNARE-like0.1337Inherited
Cystine-knot cytokines0.2021Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.2184Inherited
Lipovitellin-phosvitin complex, superhelical domain0.2184Inherited
POZ domain0.2227Inherited
PH domain-like0.271Inherited
GroEL-intermediate domain like0.2783Inherited
GroEL apical domain-like0.2783Inherited
GroEL equatorial domain-like0.2783Inherited
Tubulin nucleotide-binding domain-like0.3229Inherited
Sm-like ribonucleoproteins0.3326Inherited
HAD-like0.3508Inherited
P-loop containing nucleoside triphosphate hydrolases0.3901Inherited
Tubulin C-terminal domain-like0.4631Inherited
"Winged helix" DNA-binding domain0.5391Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.5836Inherited
Bromodomain0.7003Inherited
ABC transporter transmembrane region0.7254Inherited
Homeodomain-like0.8097Inherited
Nucleic acid-binding proteins0.883Inherited
DBL homology domain (DH-domain)0.9012Inherited
Leucine zipper domain0.9109Inherited
HLH, helix-loop-helix DNA-binding domain0.9628Inherited
Nuclear receptor ligand-binding domain0.9938Inherited
beta-beta-alpha zinc fingers1Inherited
Family A G protein-coupled receptor-like1Inherited
Ankyrin repeat1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Cullin repeat0Direct
Transducin (heterotrimeric G protein), gamma chain0Direct
Quinoprotein alcohol dehydrogenase-like0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
SCF ubiquitin ligase complex WHB domain0Direct
Skp1 dimerisation domain-like0.00000000006319Direct
Nicotinic receptor ligand binding domain-like0.00000000009642Direct
Neurotransmitter-gated ion-channel transmembrane pore0.00000000009642Direct
Protein kinases, catalytic subunit0.0000007455Direct
Cullin homology domain0.000001764Direct
cAMP-binding domain0.0001459Direct
Phosphate binding protein-like0.0001459Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0.0004768Direct
BTB/POZ domain0.0009023Direct
Transforming growth factor (TGF)-beta0.00281Inherited
Transducin (alpha subunit), insertion domain0.003914Inherited
L-arabinose binding protein-like0.003914Inherited
Synaptotagmin-like (S variant)0.005294Inherited
PLC-like (P variant)0.006831Inherited
Clathrin coat assembly domain0.01439Inherited
Phosphoribosyltransferases (PRTases)0.01439Inherited
I set domains0.01929Inherited
Multidrug efflux transporter AcrB transmembrane domain0.03218Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.03218Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.03628Inherited
Spectrin repeat0.04031Inherited
PDZ domain0.05562Inherited
Calcium ATPase, transduction domain A0.05562Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.05562Inherited
Pleckstrin-homology domain (PH domain)0.06048Inherited
G proteins0.07915Inherited
Regulator of G-protein signaling, RGS0.08585Inherited
SH3-domain0.1148Inherited
Adenylyl and guanylyl cyclase catalytic domain0.1179Inherited
t-snare proteins0.1283Inherited
Group II chaperonin (CCT, TRIC), intermediate domain0.1283Inherited
Meta-cation ATPase, catalytic domain P0.1294Inherited
Voltage-gated potassium channels0.1648Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.2157Inherited
Lipovitellin-phosvitin complex, superhelical domain0.2157Inherited
Pyridoxal-dependent decarboxylase0.2157Inherited
Calcium ATPase, transmembrane domain M0.2787Inherited
Tubulin, GTPase domain0.3276Inherited
FYVE, a phosphatidylinositol-3-phosphate binding domain0.3287Inherited
WD40-repeat0.3345Inherited
Group II chaperonin (CCT, TRIC), ATPase domain0.392Inherited
Group II chaperonin (CCT, TRIC), apical domain0.392Inherited
Tubulin, C-terminal domain0.4702Inherited
Bromodomain0.7043Inherited
Rhodopsin-like0.7687Inherited
ABC transporter transmembrane region0.8264Inherited
ABC transporter ATPase domain-like0.8295Inherited
DBL homology domain (DH-domain)0.9099Inherited
Leucine zipper domain0.9177Inherited
HLH, helix-loop-helix DNA-binding domain0.9707Inherited
Nuclear receptor1Inherited
Ankyrin repeat1Inherited
Nuclear receptor ligand-binding domain1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Transducin (heterotrimeric G protein), gamma chain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Skp1 dimerisation domain-like0.0000000000003598Direct
Nicotinic receptor ligand binding domain-like0.00000000001989Direct
Neurotransmitter-gated ion-channel transmembrane pore0.00000000003676Direct
Cullin repeat-like0.000000005402Direct
Cullin homology domain0.0000004574Direct
Protein kinase-like (PK-like)0.000003089Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0.00003148Direct
cAMP-binding domain-like0.00007254Direct
Periplasmic binding protein-like II0.0001378Direct
Periplasmic binding protein-like I0.0002377Direct
Myosin rod fragments0.0027Inherited
Transducin (alpha subunit), insertion domain0.00297Inherited
Quinoprotein alcohol dehydrogenase-like0.005313Inherited
SH2 domain0.01545Inherited
Voltage-gated potassium channels0.01616Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.01692Inherited
Cysteine-rich domain0.01886Inherited
PRTase-like0.02055Inherited
TPR-like0.02127Inherited
ENTH/VHS domain0.02344Inherited
PDZ domain-like0.02745Inherited
Multidrug efflux transporter AcrB transmembrane domain0.0281Inherited
Spectrin repeat0.03684Inherited
Immunoglobulin0.03834Inherited
Calcium ATPase, transduction domain A0.04837Inherited
Calcium ATPase, transmembrane domain M0.04837Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.04837Inherited
Troponin coil-coiled subunits0.06723Inherited
Glutathione synthetase ATP-binding domain-like0.07573Inherited
SMAD/FHA domain0.07573Inherited
SAM/Pointed domain0.07778Inherited
Regulator of G-protein signaling, RGS0.07778Inherited
WD40 repeat-like0.08734Inherited
SH3-domain0.0967Inherited
Nucleotide cyclase0.09713Inherited
EGF/Laminin0.11Inherited
t-snare proteins0.1214Inherited
SNARE-like0.1214Inherited
Cystine-knot cytokines0.1857Inherited
Lipovitellin-phosvitin complex, superhelical domain0.2014Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.2014Inherited
POZ domain0.2055Inherited
PH domain-like0.2521Inherited
GroEL equatorial domain-like0.2591Inherited
WW domain0.2591Inherited
GroEL-intermediate domain like0.2591Inherited
GroEL apical domain-like0.2591Inherited
Tubulin nucleotide-binding domain-like0.303Inherited
Sm-like ribonucleoproteins0.3125Inherited
HAD-like0.3302Inherited
Insulin-like0.3378Inherited
P-loop containing nucleoside triphosphate hydrolases0.369Inherited
Tubulin C-terminal domain-like0.4412Inherited
"Winged helix" DNA-binding domain0.5166Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.5612Inherited
Bromodomain0.6796Inherited
ABC transporter transmembrane region0.7053Inherited
Homeodomain-like0.792Inherited
Nucleic acid-binding proteins0.8679Inherited
DBL homology domain (DH-domain)0.8872Inherited
Leucine zipper domain0.8973Inherited
HLH, helix-loop-helix DNA-binding domain0.9513Inherited
Nuclear receptor ligand-binding domain0.9839Inherited
beta-beta-alpha zinc fingers1Inherited
Family A G protein-coupled receptor-like1Inherited
Ankyrin repeat1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.00000000002045Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.00000000003676Direct
    56112,55073
  • 56112 - Protein kinase-like (PK-like)
  • 55073 - Nucleotide cyclase
  • 0.00000006033Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.0003229Direct
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.0004092Direct
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.0005837Direct
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.0009166Direct
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00297Inherited
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.01171Inherited
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.01692Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.04837Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.06723Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.06723Inherited
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.06723Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.07573Inherited
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.2014Inherited
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0.2014Inherited
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.2591Inherited
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.2591Inherited
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.303Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.4026Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.7053Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.807Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.9122Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0003229Direct
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.07573Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.1214Inherited
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.2014Inherited
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.2591Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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