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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

• Disease Ontology (DO) Ontology (DO)
  DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI’s thesaurus, SNOMED and OMIM.
  
• Human Phenotype (HP) Ontology (HP)
  HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
  
• Mouse Phenotype (MP) Ontology (MP)
  MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
  
• Worm Phenotype (WP) Ontology (WP)
  WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
  
• Yeast Phenotype (YP) Ontology (YP)
  Based on YP which is the major contributor to the ‘Ascomycete phenotype ontology’, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
  
• Fly Phenotype (FP) Ontology (FP)
  FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
  
• Fly Anatomy (FA) Ontology (FA)
  FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
  
• Zebrafish Anatomy (ZA) Ontology (ZA)
  ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
  
• Xenopus Anatomy (XA) Ontology (XA)
  XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
  
• Arabidopsis Plant Ontology (AP) Ontology (AP)
  As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
  
• Enzyme Commission (EC) Ontology (EC)
  Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
  
• DrugBank ATC (DB) Ontology (DB)
  In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
  
• UniProtKB KeyWords (KW) Ontology (KW)
  Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
  
• UniProtKB UniPathway (UP) Ontology (UP)
  UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
  

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
  

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Human Phenotype (HP) Ontology (SPHP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
  

Superfamily domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Tim10-like	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
Plexin repeat	0	DIRECT
Cytidine deaminase-like	0	DIRECT
B-box zinc-binding domain	0	DIRECT
ArfGap/RecO-like zinc finger	0	DIRECT
Serine protease inhibitors	0	DIRECT
Hairpin loop containing domain-like	0	DIRECT
Di-copper centre-containing domain	0	DIRECT
SMR domain-like	0	DIRECT
Rudiment single hybrid motif	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
2Fe-2S ferredoxin-like	0	DIRECT
Caspase-like	0	DIRECT
UDP-Glycosyltransferase/glycogen phosphorylase	0	DIRECT
Cation efflux protein transmembrane domain-like	0	DIRECT
SH3-domain	0	DIRECT
Zn-dependent exopeptidases	0	DIRECT
Integrin alpha N-terminal domain	0	DIRECT
MIR domain	0	DIRECT
Ribonuclease H-like	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
PR-1-like	0	DIRECT
Isochorismatase-like hydrolases	0	DIRECT
Subtilisin-like	0	DIRECT
Globin-like	0	DIRECT
TK C-terminal domain-like	0	DIRECT
Galactose oxidase, central domain	0	DIRECT
Formin homology 2 domain (FH2 domain)	0	DIRECT
DEATH domain	0	DIRECT
Rhodanese/Cell cycle control phosphatase	0	DIRECT
Nucleic acid-binding proteins	0	DIRECT
Lipovitellin-phosvitin complex; beta-sheet shell regions	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Rap/Ran-GAP	0	DIRECT
Galactose-binding domain-like	0	DIRECT
SAND domain-like	0	DIRECT
Tropomyosin	0	DIRECT
The spindle assembly checkpoint protein mad2	0	DIRECT
SET domain	0	DIRECT
PAZ domain	0	DIRECT
WW domain	0	DIRECT
cAMP-binding domain-like	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
Immunoglobulin	0	DIRECT
Integrin domains	0	DIRECT
Galactose mutarotase-like	0	DIRECT
TIMP-like	0	DIRECT
EF-G C-terminal domain-like	0	DIRECT
HIT-like	0	DIRECT
Bactericidal permeability-increasing protein, BPI	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
Clathrin adaptor appendage domain	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
LDH C-terminal domain-like	0	DIRECT
Nucleotide-diphospho-sugar transferases	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0	DIRECT
Actin-like ATPase domain	0	DIRECT
Cadherin-like	0	DIRECT
A DNA-binding domain in eukaryotic transcription factors	0	DIRECT
PEP carboxykinase-like	0	DIRECT
C-type lectin-like	0	DIRECT
Gamma-glutamyl cyclotransferase-like	0	DIRECT
EGF/Laminin	0	DIRECT
SNF-like	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
BEACH domain	0	DIRECT
TSP-1 type 1 repeat	0	DIRECT
Phoshotransferase/anion transport protein	0	DIRECT
L-aspartase-like	0	DIRECT
Class I glutamine amidotransferase-like	0	DIRECT
E set domains	0	DIRECT
LDL receptor-like module	0	DIRECT
SCP-like	0	DIRECT
PH domain-like	0	DIRECT
Delta-sleep-inducing peptide immunoreactive peptide	0	DIRECT
LuxS/MPP-like metallohydrolase	0	DIRECT
Sm-like ribonucleoproteins	0	DIRECT
Oxysterol-binding protein-like	0	DIRECT
POZ domain	0	DIRECT
Acyl-CoA dehydrogenase NM domain-like	0	DIRECT
RING/U-box	0	DIRECT
Nucleotidylyl transferase	0	DIRECT
NHL repeat	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Cystatin/monellin	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
RCC1/BLIP-II	0	DIRECT
SAICAR synthase-like	0	DIRECT
Metallo-hydrolase/oxidoreductase	0	DIRECT
Ammonium transporter	0	DIRECT
Serpins	0	DIRECT
Kazal-type serine protease inhibitors	0	DIRECT
Glycerol-3-phosphate (1)-acyltransferase	0	DIRECT
ARM repeat	0	DIRECT
Formate/glycerate dehydrogenase catalytic domain-like	0	DIRECT
Cupredoxins	0	DIRECT
Tubby C-terminal domain-like	0	DIRECT
Carbohydrate phosphatase	0	DIRECT
Lipase/lipooxygenase domain (PLAT/LH2 domain)	0	DIRECT
CBS-domain pair	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	0	DIRECT
Heme-dependent catalase-like	0	DIRECT
SMAD/FHA domain	0	DIRECT
Activating enzymes of the ubiquitin-like proteins	0	DIRECT
Ligand-binding domain in the NO signalling and Golgi transport	0	DIRECT
SAP domain	0	DIRECT
Prefoldin	0	DIRECT
Nudix	0	DIRECT
EF-hand	0	DIRECT
Glutathione synthetase ATP-binding domain-like	0	DIRECT
FabD/lysophospholipase-like	0	DIRECT
SMAD MH1 domain	0	DIRECT
Composite domain of metallo-dependent hydrolases	0	DIRECT
Cysteine-rich domain	0	DIRECT
Pseudouridine synthase	0	DIRECT
PP2C-like	0	DIRECT
Periplasmic binding protein-like I	0	DIRECT
Glycoside hydrolase/deacetylase	0	DIRECT
MFS general substrate transporter	0	DIRECT
DNA clamp	0	DIRECT
Acid phosphatase/Vanadium-dependent haloperoxidase	0	DIRECT
Metallo-dependent phosphatases	0	DIRECT
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0	DIRECT
Cytochrome P450	0	DIRECT
Bromodomain	0	DIRECT
(Trans)glycosidases	0	DIRECT
Acyl-CoA dehydrogenase C-terminal domain-like	0	DIRECT
FYVE/PHD zinc finger	0	DIRECT
Thiamin diphosphate-binding fold (THDP-binding)	0	DIRECT
NAD kinase/diacylglycerol kinase-like	0	DIRECT
Tetraspanin	0	DIRECT
PLP-binding barrel	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
ClpP/crotonase	0	DIRECT
RuvA domain 2-like	0	DIRECT
WGR domain-like	0	DIRECT
Ferredoxin reductase-like, C-terminal NADP-linked domain	0	DIRECT
HCP-like	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
SGNH hydrolase	0	DIRECT
DNA ligase/mRNA capping enzyme, catalytic domain	0	DIRECT
S15/NS1 RNA-binding domain	0	DIRECT
Trimeric LpxA-like enzymes	0	DIRECT
NAD(P)-binding Rossmann-fold domains	0	DIRECT
ADP-ribosylation	0	DIRECT
SH2 domain	0	DIRECT
CRAL/TRIO domain	0	DIRECT
Subdomain of clathrin and coatomer appendage domain	0	DIRECT
PLP-dependent transferases	0	DIRECT
ARID-like	0	DIRECT
Ganglioside M2 (gm2) activator	0	DIRECT
TAZ domain	0	DIRECT
Protease propeptides/inhibitors	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
Lipocalins	0	DIRECT
Cyclin-like	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Intermediate filament protein, coiled coil region	0	DIRECT
Ferritin-like	0	DIRECT
Molybdenum cofactor biosynthesis proteins	0	DIRECT
Glucocorticoid receptor-like (DNA-binding domain)	0	DIRECT
Second domain of FERM	0	DIRECT
Ribokinase-like	0	DIRECT
C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
DNA/RNA polymerases	0	DIRECT
Invertebrate chitin-binding proteins	0	DIRECT
HD-domain/PDEase-like	0	DIRECT
HMG-box	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
HSP20-like chaperones	0	DIRECT
HRDC-like	0	DIRECT
Spectrin repeat	0	DIRECT
Chaperone J-domain	0	DIRECT
Calcium ATPase, transduction domain A	0	DIRECT
FKBP-like	0	DIRECT
Heme-dependent peroxidases	0	DIRECT
Spermadhesin, CUB domain	0	DIRECT
GYF domain	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
FAD/NAD(P)-binding domain	0	DIRECT
PHM/PNGase F	0	DIRECT
DHS-like NAD/FAD-binding domain	0	DIRECT
Zn-binding ribosomal proteins	0	DIRECT
vWA-like	0	DIRECT
PABC (PABP) domain	0	DIRECT
LEM domain	0	DIRECT
KA1-like	0	DIRECT
Carbonic anhydrase	0	DIRECT
YWTD domain	0	DIRECT
TRAF domain-like	0	DIRECT
Alpha-L RNA-binding motif	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
Hect, E3 ligase catalytic domain	0	DIRECT
Hemopexin-like domain	0	DIRECT
Complement control module/SCR domain	0	DIRECT
CalX-like	0	DIRECT
Multidrug resistance efflux transporter EmrE	0	DIRECT
PLC-like phosphodiesterases	0	DIRECT
UBC-like	0	DIRECT
Tubulin nucleotide-binding domain-like	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
Class II aaRS and biotin synthetases	0	DIRECT
GroEL apical domain-like	0	DIRECT
AraD/HMP-PK domain-like	0	DIRECT
Leucine zipper domain	0	DIRECT
ALDH-like	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
Glutamine synthetase/guanido kinase	0	DIRECT
MgtE membrane domain-like	0	DIRECT
Class II aaRS ABD-related	0	DIRECT
L30e-like	0	DIRECT
PEBP-like	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
Small-conductance potassium channel	0	DIRECT
MIT domain	0	DIRECT
E2F-DP heterodimerization region	0	DIRECT
Clavaminate synthase-like	0	DIRECT
Phosphoglycerate mutase-like	0	DIRECT
alpha/beta-Hydrolases	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
beta-lactamase/transpeptidase-like	0	DIRECT
WD40 repeat-like	0	DIRECT
JAB1/MPN domain	0	DIRECT
Voltage-gated potassium channels	0	DIRECT
HIT/MYND zinc finger-like	0	DIRECT
Nicotinic receptor ligand binding domain-like	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
"Winged helix" DNA-binding domain	0	DIRECT
Families 57/38 glycoside transferase middle domain	0	DIRECT
Smc hinge domain	0	DIRECT
PapD-like	0	DIRECT
Lysozyme-like	0	DIRECT
Saposin	0	DIRECT
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0	DIRECT
Ribosomal protein S18	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
CoA-dependent acyltransferases	0	DIRECT
Elafin-like	0	DIRECT
DNase I-like	0	DIRECT
Vitelline membrane outer protein-I (VMO-I)	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
Ras GEF	0	DIRECT
GHMP Kinase, C-terminal domain	0	DIRECT
Tricorn protease domain 2	0	DIRECT
Terpenoid cyclases/Protein prenyltransferases	0	DIRECT
Metal cation-transporting ATPase, ATP-binding domain N	0	DIRECT
Tudor/PWWP/MBT	0	DIRECT
Mitochondrial carrier	0	DIRECT
PX domain	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
Riboflavin synthase domain-like	0	DIRECT
ACP-like	0	DIRECT
Chromo domain-like	0	DIRECT
Sec7 domain	0	DIRECT
post-AAA+ oligomerization domain-like	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
Translation proteins SH3-like domain	0	DIRECT
6-phosphogluconate dehydrogenase C-terminal domain-like	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
Acetyl-CoA synthetase-like	0	DIRECT
Nuclear receptor ligand-binding domain	0	DIRECT
MFPT repeat-like	0	DIRECT
F-box domain	0	DIRECT
Family A G protein-coupled receptor-like	0	DIRECT
Phospholipase A2, PLA2	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
PDZ domain-like	0	DIRECT
Nucleoporin domain	0	DIRECT
Rhomboid-like	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
RmlC-like cupins	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Calponin-homology domain, CH-domain	0	DIRECT
Radical SAM enzymes	0	DIRECT
Thioesterase/thiol ester dehydrase-isomerase	0	DIRECT
Cystine-knot cytokines	0	DIRECT
Carbon-nitrogen hydrolase	0	DIRECT
Nucleotide-binding domain	0	DIRECT
Ribosomal protein S5 domain 2-like	0	DIRECT
Flavoproteins	0	DIRECT
ADC-like	0	DIRECT
PA domain	0	DIRECT
SPOC domain-like	0	DIRECT
3-carboxy-cis,cis-mucoante lactonizing enzyme	0	DIRECT
4Fe-4S ferredoxins	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
Bet v1-like	0	DIRECT
Pentein	0	DIRECT
Lamin A/C globular tail domain	0	DIRECT
L domain-like	0	DIRECT
t-snare proteins	0	DIRECT
GST C-terminal domain-like	0	DIRECT
PYP-like sensor domain (PAS domain)	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
Mob1/phocein	0	DIRECT
Type II DNA topoisomerase	0	DIRECT
DLC	0	DIRECT
Restriction endonuclease-like	0	DIRECT
dsRNA-binding domain-like	0	DIRECT
FAD-binding/transporter-associated domain-like	0	DIRECT
HAD-like	0	DIRECT
FAD-linked reductases, C-terminal domain	0	DIRECT
Troponin coil-coiled subunits	0	DIRECT
Tubulin C-terminal domain-like	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
Kix domain of CBP (creb binding protein)	0	DIRECT
Lipovitellin-phosvitin complex, superhelical domain	0	DIRECT
TPR-like	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Single hybrid motif	0	DIRECT
Protein kinase-like (PK-like)	0	DIRECT
Calcium ATPase, transmembrane domain M	0	DIRECT
RNI-like	0	DIRECT
Clc chloride channel	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
PRTase-like	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
Glycosyl hydrolase domain	0	DIRECT
Transferrin receptor-like dimerisation domain	0	DIRECT
GAT-like domain	0	DIRECT
P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
Ribosomal proteins S24e, L23 and L15e	0	DIRECT
Fibronectin type III	0	DIRECT
Cullin homology domain	0	DIRECT
ThrRS/AlaRS common domain	0	DIRECT
ENTH/VHS domain	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
RUN domain-like	0	DIRECT
Alkaline phosphatase-like	0	DIRECT
Cytochrome b5-like heme/steroid binding domain	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Neurotransmitter-gated ion-channel transmembrane pore	0	DIRECT
Hormone receptor domain	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
Eukaryotic type KH-domain (KH-domain type I)	0	DIRECT
GroES-like	0	DIRECT
Tautomerase/MIF	0	DIRECT
Zinc beta-ribbon	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
Nucleotide cyclase	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
Isocitrate/Isopropylmalate dehydrogenase-like	0	DIRECT
lambda repressor-like DNA-binding domains	0	DIRECT
Nop domain	0	DIRECT
Myosin rod fragments	0	DIRECT
NagB/RpiA/CoA transferase-like	0	DIRECT
Calcium-dependent phosphotriesterase	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
PAP/OAS1 substrate-binding domain	0	DIRECT
YbiA-like	0	DIRECT
SAM/Pointed domain	0	DIRECT
RNA-binding domain, RBD	0	DIRECT
Ankyrin repeat	0	DIRECT
alpha-helical ferredoxin	0	DIRECT
Periplasmic binding protein-like II	0	DIRECT
Ricin B-like lectins	0	DIRECT
Carboxypeptidase regulatory domain-like	0	DIRECT
Concanavalin A-like lectins/glucanases	0	DIRECT
Frizzled cysteine-rich domain	0	DIRECT
Phospholipase D/nuclease	0	DIRECT
SNARE-like	0	DIRECT
Tryptophan synthase beta subunit-like PLP-dependent enzymes	0	DIRECT
Osmotin, thaumatin-like protein	0	DIRECT
Translation proteins	0	DIRECT
Insulin-like	0	DIRECT
SIS domain	0	DIRECT
Ribosomal proteins L15p and L18e	0	DIRECT
ABC transporter transmembrane region	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
beta-beta-alpha zinc fingers	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
GINS helical bundle-like	0	DIRECT
GroEL equatorial domain-like	0	DIRECT
Aminoacid dehydrogenase-like, N-terminal domain	0	DIRECT
Acid proteases	0	DIRECT
PIN domain-like	0	DIRECT
PGBD-like	0	DIRECT
p53-like transcription factors	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
FtsH protease domain-like	0	DIRECT
Translational machinery components	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
alpha-catenin/vinculin-like	0	DIRECT
SNARE fusion complex	0	DIRECT
NAD(P)-linked oxidoreductase	0	DIRECT
PUA domain-like	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
Growth factor receptor domain	0	DIRECT
Six-hairpin glycosidases	0	DIRECT
ISP domain	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
PK beta-barrel domain-like	0	DIRECT
Chitinase insertion domain	0	DIRECT
PreATP-grasp domain	0	DIRECT
GTPase activation domain, GAP	0	DIRECT
Ubiquitin-like	0	DIRECT
Aldolase	0	DIRECT
Cysteine proteinases	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
UBA-like	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
Ypt/Rab-GAP domain of gyp1p	0	DIRECT
Homeodomain-like	0	DIRECT
Apyrase	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
Putative DNA-binding domain	0	DIRECT
Cyclophilin-like	0	DIRECT
Thiolase-like	0	DIRECT
BAR/IMD domain-like	0	DIRECT
Cap-Gly domain	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Arginase/deacetylase	0	DIRECT
Kelch motif	0	DIRECT
R3H domain	0	DIRECT
TGS-like	0	DIRECT
Aquaporin-like	0	DIRECT
Metalloproteases ("zincins"), catalytic domain	0	DIRECT
eIF4e-like	0	DIRECT
Adenine nucleotide alpha hydrolases-like	0	DIRECT
Band 7/SPFH domain	0	DIRECT
Cytochrome c	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
Sec63 N-terminal domain-like	0	DIRECT
S-adenosyl-L-methionine-dependent methyltransferases	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
FF domain	0	DIRECT
Purine and uridine phosphorylases	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
Ribosomal protein S10	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
(Phosphotyrosine protein) phosphatases II	0	DIRECT
Doublecortin (DC)	0	DIRECT
Polo-box domain	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
Sema domain	0	DIRECT
Roadblock/LC7 domain	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
BPTI-like	0	DIRECT
Phosphoenolpyruvate/pyruvate domain	0	DIRECT
Acyl-CoA N-acyltransferases (Nat)	0	DIRECT
Calpain large subunit, middle domain (domain III)	0	DIRECT
Citrate synthase	0	DIRECT
CCCH zinc finger	0	DIRECT
NTF2-like	0	DIRECT
Histone-fold	0	DIRECT
CAD & PB1 domains	0	DIRECT
SpoIIaa-like	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
Annexin	0	DIRECT
Actin depolymerizing proteins	0	DIRECT
BRCT domain	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
Nucleotidyltransferase	0	DIRECT
Metallo-dependent hydrolases	0	DIRECT
Cullin repeat-like	0	DIRECT
Mss4-like	0	DIRECT
Hedgehog/intein (Hint) domain	0	DIRECT

Family domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Mammalian PLC	0	DIRECT
Annexin	0	DIRECT
Oxysterol-binding protein	0	DIRECT
4HBT-like	0	DIRECT
DnaQ-like 3'-5' exonuclease	0	DIRECT
Ribokinase-like	0	DIRECT
UBX domain	0	DIRECT
Third domain of FERM	0	DIRECT
Caspase catalytic domain	0	DIRECT
Insulin-like	0	DIRECT
SAP domain	0	DIRECT
Bacterial dinuclear zinc exopeptidases	0	DIRECT
Armadillo repeat	0	DIRECT
Biotin dependent carboxylase carboxyltransferase domain	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Extended AAA-ATPase domain	0	DIRECT
PABC (PABP) domain	0	DIRECT
Cystathionine synthase-like	0	DIRECT
Cyclin	0	DIRECT
RNA editing terminal uridyl transferase 2, RET2, domain 2	0	DIRECT
WW domain	0	DIRECT
Cadherin	0	DIRECT
Sm motif of small nuclear ribonucleoproteins, SNRNP	0	DIRECT
Clathrin adaptor core protein	0	DIRECT
Pancreatic carboxypeptidase, activation domain	0	DIRECT
Glutathione S-transferase (GST), N-terminal domain	0	DIRECT
GAPDH-like	0	DIRECT
Fibronectin type III	0	DIRECT
Acyl-CoA thioesterase	0	DIRECT
Ribosomal proteins L15p and L18e	0	DIRECT
Dual specificity phosphatase-like	0	DIRECT
Glycerol kinase	0	DIRECT
Regulator of chromosome condensation RCC1	0	DIRECT
Nicotinic receptor ligand binding domain-like	0	DIRECT
Galectin (animal S-lectin)	0	DIRECT
H-NOX domain	0	DIRECT
Autophagin-like	0	DIRECT
Small Kunitz-type inhibitors & BPTI-like toxins	0	DIRECT
Inositol monophosphatase/fructose-1,6-bisphosphatase-like	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
Translation initiation factor eIF4e	0	DIRECT
YbiA-like	0	DIRECT
ABC transporter transmembrane region	0	DIRECT
Gamma-glutamyltranspeptidase-like	0	DIRECT
Myeloperoxidase-like	0	DIRECT
EGF-type module	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
Ras GEF	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
NagD-like	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
1,3-glucuronyltransferase	0	DIRECT
MutT-like	0	DIRECT
Acetylcholinesterase-like	0	DIRECT
Protein prenyltransferases	0	DIRECT
Calcium ATPase, transduction domain A	0	DIRECT
Polypeptide N-acetylgalactosaminyltransferase 1, N-terminal domain	0	DIRECT
Heme-dependent catalases	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
MIF-related	0	DIRECT
CalX-beta domain	0	DIRECT
Forkhead DNA-binding domain	0	DIRECT
Calmodulin-like	0	DIRECT
DPP6 catalytic domain-like	0	DIRECT
2Fe-2S ferredoxin domains from multidomain proteins	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
Small-conductance potassium channel	0	DIRECT
Lipovitellin-phosvitin complex; beta-sheet shell regions	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Cell cycle transcription factor e2f-dp	0	DIRECT
Proprotein convertase P-domain	0	DIRECT
First domain of FERM	0	DIRECT
FolH catalytic domain-like	0	DIRECT
Motor proteins	0	DIRECT
ZZ domain	0	DIRECT
Hect, E3 ligase catalytic domain	0	DIRECT
T-box	0	DIRECT
VHS domain	0	DIRECT
MFPT repeat	0	DIRECT
U-box	0	DIRECT
Second domain of FERM	0	DIRECT
FAD/NAD-linked reductases, N-terminal and central domains	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Class II glutamine amidotransferases	0	DIRECT
Histidine acid phosphatase	0	DIRECT
Sema domain	0	DIRECT
EF-hand modules in multidomain proteins	0	DIRECT
Ribonuclease H	0	DIRECT
Tyrosine-dependent oxidoreductases	0	DIRECT
Ras-binding domain, RBD	0	DIRECT
CAT-like	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
LDL receptor-like module	0	DIRECT
PR-1-like	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	0	DIRECT
Aminoacid dehydrogenase-like, C-terminal domain	0	DIRECT
Myotubularin-like phosphatases	0	DIRECT
Pyridoxal-dependent decarboxylase	0	DIRECT
DEATH domain, DD	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
Ubiquitin-related	0	DIRECT
Tetraspanin	0	DIRECT
Doublecortin (DC)	0	DIRECT
Metal cation-transporting ATPase, ATP-binding domain N	0	DIRECT
beta-Lactamase/D-ala carboxypeptidase	0	DIRECT
Ribonucleotide reductase-like	0	DIRECT
Erythroid transcription factor GATA-1	0	DIRECT
Rhodopsin-like	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
Glycerol-3-phosphate transporter	0	DIRECT
Osmotin, thaumatin-like protein	0	DIRECT
Choline/Carnitine O-acyltransferase	0	DIRECT
Hemocyanin middle domain	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
AraD-like aldolase/epimerase	0	DIRECT
Meta-cation ATPase, catalytic domain P	0	DIRECT
Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
Group II chaperonin (CCT, TRIC), ATPase domain	0	DIRECT
RecA protein-like (ATPase-domain)	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
Trunk domain of Sec23/24	0	DIRECT
AMPK-beta glycogen binding domain-like	0	DIRECT
TBP-associated factors, TAFs	0	DIRECT
DNA gyrase/MutL, N-terminal domain	0	DIRECT
LIM domain	0	DIRECT
L-aminoacid/polyamine oxidase	0	DIRECT
Spectrin repeat	0	DIRECT
Acylamino-acid-releasing enzyme, C-terminal donain	0	DIRECT
Glycogenin	0	DIRECT
TSP-1 type 1 repeat	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Hexokinase	0	DIRECT
Cyclophilin (peptidylprolyl isomerase)	0	DIRECT
Band 7/SPFH domain	0	DIRECT
FucT-like	0	DIRECT
UBA domain	0	DIRECT
Phosphatidylethanolamine binding protein	0	DIRECT
Voltage-gated potassium channels	0	DIRECT
Single strand DNA-binding domain, SSB	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase, UCH	0	DIRECT
GYF domain	0	DIRECT
Phosphoribosyltransferases (PRTases)	0	DIRECT
MIF4G domain-like	0	DIRECT
BAR domain	0	DIRECT
TAZ domain	0	DIRECT
RING finger domain, C3HC4	0	DIRECT
Arginine methyltransferase	0	DIRECT
Neutral endopeptidase (neprilysin)	0	DIRECT
NADPH-cytochrome p450 reductase FAD-binding domain-like	0	DIRECT
Carbonic anhydrase	0	DIRECT
L30e/L7ae ribosomal proteins	0	DIRECT
Lactate & malate dehydrogenases, C-terminal domain	0	DIRECT
Synaptotagmin-like (S variant)	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
Poly(ADP-ribose) polymerase, C-terminal domain	0	DIRECT
MPP-like	0	DIRECT
Transcriptional factor domain	0	DIRECT
FCH domain	0	DIRECT
acyl-CoA oxidase C-terminal domains	0	DIRECT
Cullin homology domain	0	DIRECT
ALDH-like	0	DIRECT
acyl-CoA oxidase N-terminal domains	0	DIRECT
Troponin I	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
Acetyl-CoA synthetase-like	0	DIRECT
AAT-like	0	DIRECT
Matrix metalloproteases, catalytic domain	0	DIRECT
Calpain large subunit, middle domain (domain III)	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	0	DIRECT
UBC-related	0	DIRECT
Rhomboid-like	0	DIRECT
D-aminoacid oxidase, N-terminal domain	0	DIRECT
Homeodomain	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
Ribosomal protein S18	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
NHL repeat	0	DIRECT
Class I alpha-1;2-mannosidase, catalytic domain	0	DIRECT
Pyk2-associated protein beta ARF-GAP domain	0	DIRECT
5' to 3' exonuclease catalytic domain	0	DIRECT
Hormone receptor domain	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
PHD domain	0	DIRECT
Smr domain	0	DIRECT
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain	0	DIRECT
alpha-mannosidase, domain 2	0	DIRECT
Thioltransferase	0	DIRECT
Tandem AAA-ATPase domain	0	DIRECT
RIO1-like kinases	0	DIRECT
Transforming growth factor (TGF)-beta	0	DIRECT
Plexin repeat	0	DIRECT
SH3-domain	0	DIRECT
PAPS sulfotransferase	0	DIRECT
YWTD domain	0	DIRECT
WGR domain	0	DIRECT
Paired domain	0	DIRECT
Ovomucoid domain III-like	0	DIRECT
Fatty acid binding protein-like	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
BEACH domain	0	DIRECT
Clc chloride channel	0	DIRECT
Serpins	0	DIRECT
FYVE, a phosphatidylinositol-3-phosphate binding domain	0	DIRECT
SAM (sterile alpha motif) domain	0	DIRECT
Proteasome subunits	0	DIRECT
Histone deacetylase, HDAC	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
Inositol polyphosphate kinase (IPK)	0	DIRECT
Amylase, catalytic domain	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
Crotonase-like	0	DIRECT
Ubiquitin activating enzymes (UBA)	0	DIRECT
NADPH-cytochrome p450 reductase-like	0	DIRECT
alpha-mannosidase, C-terminal domain	0	DIRECT
NTF2-like	0	DIRECT
Cytidylyltransferase	0	DIRECT
Isochorismatase-like hydrolases	0	DIRECT
Adenain-like	0	DIRECT
Hydantoinase (dihydropyrimidinase)	0	DIRECT
Cofilin-like	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
Formin homology 2 domain (FH2 domain)	0	DIRECT
Alcohol dehydrogenase-like, C-terminal domain	0	DIRECT
Carboxylesterase	0	DIRECT
Cytochrome b5	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
Ngr ectodomain-like	0	DIRECT
FHA domain	0	DIRECT
beta-CASP RNA-metabolising hydrolases	0	DIRECT
Canonical RBD	0	DIRECT
CBS-domain pair	0	DIRECT
PP2C-like	0	DIRECT
RUN domain	0	DIRECT
Integrin domains	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
Spermadhesin, CUB domain	0	DIRECT
Rap/Ran-GAP	0	DIRECT
SMAD MH1 domain	0	DIRECT
MIT domain	0	DIRECT
Chitinase insertion domain	0	DIRECT
SWIRM domain	0	DIRECT
Glutathione S-transferase (GST), C-terminal domain	0	DIRECT
PB1 domain	0	DIRECT
Ribosomal protein L18 and S11	0	DIRECT
NLI interacting factor-like phosphatase	0	DIRECT
G proteins	0	DIRECT
Translational machinery components	0	DIRECT
Reprolysin-like	0	DIRECT
N-acetyl transferase, NAT	0	DIRECT
Ankyrin repeat	0	DIRECT
alpha-mannosidase	0	DIRECT
Bactericidal permeability-increasing protein, BPI	0	DIRECT
Calpain large subunit, catalytic domain (domain II)	0	DIRECT
Tubulin, C-terminal domain	0	DIRECT
CoA-binding domain	0	DIRECT
Clathrin coat assembly domain	0	DIRECT
Prefoldin	0	DIRECT
Calponin-homology domain, CH-domain	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
Double-stranded RNA-binding domain (dsRBD)	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
UDPGT-like	0	DIRECT
ABC transporter ATPase domain-like	0	DIRECT
HCDH C-domain-like	0	DIRECT
Leukotriene A4 hydrolase catalytic domain	0	DIRECT
Phoshoinositide 3-kinase (PI3K) helical domain	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
28-residue LRR	0	DIRECT
Neurotransmitter-gated ion-channel transmembrane pore	0	DIRECT
Patatin	0	DIRECT
Cytoplasmic domain of inward rectifier potassium channel	0	DIRECT
Biotinyl/lipoyl-carrier proteins and domains	0	DIRECT
Pancreatic carboxypeptidases	0	DIRECT
Class I aldolase	0	DIRECT
Tetratricopeptide repeat (TPR)	0	DIRECT
Nuclear receptor ligand-binding domain	0	DIRECT
Alcohol dehydrogenase-like, N-terminal domain	0	DIRECT
Thiolase-related	0	DIRECT
Serine carboxypeptidase-like	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Citrate synthase	0	DIRECT
Glutamine synthetase catalytic domain	0	DIRECT
Linker histone H1/H5	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
Anticodon-binding domain of Class II aaRS	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
FF domain	0	DIRECT
LEM domain	0	DIRECT
Smc hinge domain	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
LacY-like proton/sugar symporter	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
PDI-like	0	DIRECT
Transferrin receptor-like dimerisation domain	0	DIRECT
Nitrogenase iron protein-like	0	DIRECT
Tryptophan synthase beta subunit-like PLP-dependent enzymes	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Lipovitellin-phosvitin complex, superhelical domain	0	DIRECT
DEP domain	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
DNA polymerase III clamp loader subunits, C-terminal domain	0	DIRECT
beta 1,4 galactosyltransferase (b4GalT1)	0	DIRECT
Formate/glycerate dehydrogenases, NAD-domain	0	DIRECT
SCF ubiquitin ligase complex WHB domain	0	DIRECT
Filamin repeat (rod domain)	0	DIRECT
HMG-box	0	DIRECT
Phosphotyrosine-binding domain (PTB)	0	DIRECT
C-type lectin domain	0	DIRECT
Pleckstrin-homology domain (PH domain)	0	DIRECT
UDP-glucose pyrophosphorylase	0	DIRECT
Phoshoinositide 3-kinase (PI3K), catalytic domain	0	DIRECT
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain	0	DIRECT
Nucleosome core histones	0	DIRECT
Globins	0	DIRECT
Myosin rod fragments	0	DIRECT
Myb/SANT domain	0	DIRECT
AlkB-like	0	DIRECT
WD40-repeat	0	DIRECT
Cytochrome P450	0	DIRECT
Papain-like	0	DIRECT
YicI catalytic domain-like	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
t-snare proteins	0	DIRECT
BC C-terminal domain-like	0	DIRECT
Extended PAW domain	0	DIRECT
Pseudouridine synthase I TruA	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
SMAD domain	0	DIRECT
PDZ domain	0	DIRECT
Rv2717c-like	0	DIRECT
HD domain	0	DIRECT
SPRY domain	0	DIRECT
BTB/POZ domain	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain	0	DIRECT
L-arabinose binding protein-like	0	DIRECT
Lesion bypass DNA polymerase (Y-family), catalytic domain	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase PP module	0	DIRECT
Subtilases	0	DIRECT
Protein kinases, catalytic subunit	0	DIRECT
Hemopexin-like domain	0	DIRECT
cAMP-binding domain	0	DIRECT
Eps15 homology domain (EH domain)	0	DIRECT
La domain	0	DIRECT
Leucine zipper domain	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase Pyr module	0	DIRECT
SNARE fusion complex	0	DIRECT
Astacin	0	DIRECT
BC N-terminal domain-like	0	DIRECT
Apyrase	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain	0	DIRECT
Intermediate filament protein, coiled coil region	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
SNF-like	0	DIRECT
Cation efflux protein transmembrane domain-like	0	DIRECT
E2F dimerization segment	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
Integrin A (or I) domain	0	DIRECT
D-aminoacid oxidase-like	0	DIRECT
PA domain	0	DIRECT
ATP-dependent protease Lon (La), catalytic domain	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
N-acetylglucosaminyltransferase I	0	DIRECT
SAND domain	0	DIRECT
Class I aminoacyl-tRNA synthetases (RS), catalytic domain	0	DIRECT
FKBP immunophilin/proline isomerase	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
Sir2 family of transcriptional regulators	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Aquaporin-like	0	DIRECT
Sec7 domain	0	DIRECT
Tropomyosin	0	DIRECT
Hermes transposase-like	0	DIRECT
HEAT repeat	0	DIRECT
Polo-box duplicated region	0	DIRECT
Eukaryotic type KH-domain (KH-domain type I)	0	DIRECT
Ferredoxin domains from multidomain proteins	0	DIRECT
DNA gyrase/MutL, second domain	0	DIRECT
PUA domain	0	DIRECT
a tRNA synthase domain	0	DIRECT
CRAL/TRIO domain	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta	0	DIRECT
Dimeric isocitrate & isopropylmalate dehydrogenases	0	DIRECT
Kix domain of CBP (creb binding protein)	0	DIRECT
EF-G/eEF-2 domains III and V	0	DIRECT
ARID domain	0	DIRECT
Pepsin-like	0	DIRECT
Roadblock/LC7 domain	0	DIRECT
Cap-Gly domain	0	DIRECT
Tetramerization domain of potassium channels	0	DIRECT
Catalytic, N-terminal domain of histone methyltransferase Dot1l	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
ATI-like	0	DIRECT
Higher-molecular-weight phosphotyrosine protein phosphatases	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
A DNA-binding domain in eukaryotic transcription factors	0	DIRECT
Nuclear receptor	0	DIRECT
Inositol polyphosphate 5-phosphatase (IPP5)	0	DIRECT
COMT-like	0	DIRECT
Calcium ATPase, transmembrane domain M	0	DIRECT
DLC	0	DIRECT
PDEase	0	DIRECT
PAZ domain	0	DIRECT
I set domains	0	DIRECT
Laminin G-like module	0	DIRECT
STAR domain	0	DIRECT
N-type ATP pyrophosphatases	0	DIRECT
Ganglioside M2 (gm2) activator	0	DIRECT
Cell cycle control phosphatase, catalytic domain	0	DIRECT
Nucleotide and nucleoside kinases	0	DIRECT
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)	0	DIRECT
Laminin-type module	0	DIRECT
PEP carboxykinase C-terminal domain	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
Deoxycytidylate deaminase-like	0	DIRECT
Gastric lipase	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
Guanido kinase catalytic domain	0	DIRECT
Delta-sleep-inducing peptide immunoreactive peptide	0	DIRECT
MSP-like	0	DIRECT
DNA polymerase I	0	DIRECT
Choline kinase	0	DIRECT
MIR domain	0	DIRECT
POU-specific domain	0	DIRECT
Type II chitinase	0	DIRECT
Arylsulfatase	0	DIRECT
Glycerophosphoryl diester phosphodiesterase	0	DIRECT
Anticodon-binding domain	0	DIRECT
Cold shock DNA-binding domain-like	0	DIRECT
RhoGDI-like	0	DIRECT
Adenosine/AMP deaminase	0	DIRECT
FtsH protease domain-like	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
Ammonium transporter	0	DIRECT
Epoxide hydrolase	0	DIRECT
BCR-homology GTPase activation domain (BH-domain)	0	DIRECT
Tubulin, GTPase domain	0	DIRECT
LDH N-terminal domain-like	0	DIRECT
Ribosomal protein S10	0	DIRECT
HSP20	0	DIRECT
Histone lysine methyltransferases	0	DIRECT
alpha-catenin/vinculin	0	DIRECT
Nop domain	0	DIRECT
Multidomain sulfurtransferase (rhodanese)	0	DIRECT
Adenylyl and guanylyl cyclase catalytic domain	0	DIRECT
Glutaminase	0	DIRECT
Hedgehog C-terminal (Hog) autoprocessing domain	0	DIRECT
Diap1 N-terninal region-like	0	DIRECT
Elafin-like	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
Tim10/DDP	0	DIRECT
Protein serine/threonine phosphatase	0	DIRECT
Bromodomain	0	DIRECT
6-phosphogluconate dehydrogenase-like, N-terminal domain	0	DIRECT
Gelsolin-like	0	DIRECT
Chromo domain	0	DIRECT
Complement control module/SCR domain	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
Cullin repeat	0	DIRECT
Mo25 protein	0	DIRECT
Trehalase-like	0	DIRECT
Tudor domain	0	DIRECT
Acyl-carrier protein (ACP)	0	DIRECT
PX domain	0	DIRECT
Peptidylglycine alpha-hydroxylating monooxygenase, PHM	0	DIRECT
beta-glycanases	0	DIRECT
Carboxypeptidase regulatory domain	0	DIRECT
Serum paraoxonase/arylesterase 1, PON1	0	DIRECT
Mitochondrial carrier	0	DIRECT
B-box zinc-binding domain	0	DIRECT
Pumilio repeat	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
SH2 domain	0	DIRECT
Ricin B-like	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Bacterial lipase	0	DIRECT
Hydantoinase (dihydropyrimidinase), catalytic domain	0	DIRECT
FAD-linked reductases, N-terminal domain	0	DIRECT
p120GAP domain-like	0	DIRECT
Glycosyl transferases group 1	0	DIRECT
F-box domain	0	DIRECT
Vitelline membrane outer protein-I (VMO-I)	0	DIRECT
GABA-aminotransferase-like	0	DIRECT
RNA methyltransferase FtsJ	0	DIRECT
Type II DNA topoisomerase	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
Elongation factors	0	DIRECT
Kelch motif	0	DIRECT
Phosphate binding protein-like	0	DIRECT
DNA replication initiator (cdc21/cdc54) N-terminal domain	0	DIRECT
Group II chaperonin (CCT, TRIC), apical domain	0	DIRECT
Fungal lipases	0	DIRECT
Frizzled cysteine-rich domain	0	DIRECT
Methionine aminopeptidase, insert domain	0	DIRECT
PLC-like (P variant)	0	DIRECT
Classic zinc finger, C2H2	0	DIRECT
Cdc48 N-terminal domain-like	0	DIRECT
Lamin A/C globular tail domain	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
Internalin LRR domain	0	DIRECT
Aldo-keto reductases (NADP)	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
CCCH zinc finger	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
Growth factor receptor domain	0	DIRECT
Chaperone J-domain	0	DIRECT
MATH domain	0	DIRECT
Actin/HSP70	0	DIRECT
XPF/Rad1/Mus81 nuclease	0	DIRECT
Ribonuclease PH domain 1-like	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Ypt/Rab-GAP domain of gyp1p	0	DIRECT
Purine and uridine phosphorylases	0	DIRECT
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains	0	DIRECT
Ephrin ectodomain	0	DIRECT
CUT domain	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
Mob1/phocein	0	DIRECT
BC ATP-binding domain-like	0	DIRECT
Sterol carrier protein, SCP	0	DIRECT
ets domain	0	DIRECT