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Worm Phenotype (WP): cell physiology variant

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Variant [WBPhenotype:0000886] <5>
+ 1:   physiology variant [WBPhenotype:0000519] <6>(495|573) (496|248|69)
0:   cell physiology variant [WBPhenotype:0000536] <27>(145|145) (146|64|18)
- 1:   cell division variant [WBPhenotype:0000746] <19>(50|49) (50|20|5)
- 1:   cell homeostasis metabolism variant [WBPhenotype:0000585] <12>(58|54) (59|22|10)
- 1:   neuron physiology variant [WBPhenotype:0000991] <7>(2|5) (2|1|0)
- 1:   cell secretion variant [WBPhenotype:0000258] <6>(7|8) (8|1|0)
- 1:   cell cycle variant [WBPhenotype:0000740] <5>(4|3) (4|1|0)
- 1:   calcium mediated signaling variant [WBPhenotype:0002170] <4>(0|0) (0|0|0)
- 1:   germ cell physiology variant [WBPhenotype:0000987] <4>(7|5) (7|0|0)
- 1:   nuclear positioning variant [WBPhenotype:0000511] <4>(12|14) (13|5|1)
- 1:   cell death variant [WBPhenotype:0000729] <3>(58|51) (59|17|5)
- 1:   cell membrane physiology variant [WBPhenotype:0001965] <3>(0|0) (0|0|0)
- 1:   membrane trafficking variant [WBPhenotype:0001833] <3>(3|3) (3|1|0)
- 1:   muscle cell physiology variant [WBPhenotype:0000990] <3>(16|16) (17|9|3)
- 1:   oocyte physiology variant [WBPhenotype:0001424] <3>(13|14) (14|6|1)
- 1:   endocytic transport variant [WBPhenotype:0001421] <2>(28|26) (30|11|2)
- 1:   coelomocyte physiology variant [WBPhenotype:0001423] <1>(7|7) (8|2|0)
- 1:   embryonic cell physiology variant [WBPhenotype:0000763] <1>(13|17) (13|6|0)
- 1:   epithelial cell physiology variant [WBPhenotype:0000986] <1>(3|3) (3|2|1)
- 1:   lysosome homeostasis deficient [WBPhenotype:0001784] <1>(0|0) (0|0|0)
- 1:   lysosome organization biogenesis variant [WBPhenotype:0001430] <1>(3|3) (3|2|2)
- 1:   nuclear division variant [WBPhenotype:0000504] <1>(7|8) (7|3|2)
- 1:   plasma membrane composition variant [WBPhenotype:0002177] <1>(4|1) (4|1|1)
- 1:   blast cell physiology variant [WBPhenotype:0000985](0|0) (0|0|0)
- 1:   cell growth variant [WBPhenotype:0010001](0|0) (0|0|0)
- 1:   gland cell physiology variant [WBPhenotype:0000988](0|0) (0|0|0)
- 1:   marginal cell physiology variant [WBPhenotype:0000989](0|0) (0|0|0)
- 1:   peroxisome physiology variant [WBPhenotype:0001264](0|0) (0|0|0)
- 1:   vesicle trafficking variant [WBPhenotype:0001752](0|0) (0|0|0)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Sec7 domain0Direct
Cullin homology domain0Direct
LEM domain0Direct
DNA repair protein MutS, domain III0Direct
Histone-fold0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
DLC0Direct
Ribosomal protein L10-like0Direct
HSP90 C-terminal domain0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Helical domain of Sec23/240Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Type II DNA topoisomerase0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
The spindle assembly checkpoint protein mad20Direct
14-3-3 protein0Direct
RBP11-like subunits of RNA polymerase0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
PX domain0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
Profilin (actin-binding protein)0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Zn-finger domain of Sec23/240Direct
Smc hinge domain0Direct
ARM repeat0Direct
VPS9 domain0Direct
Clathrin adaptor appendage domain0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Restriction endonuclease-like0Direct
Ribosomal protein S100Direct
Nicotinic receptor ligand binding domain-like0.000000000000394Direct
Nucleic acid-binding proteins0.0000000000004018Direct
"Winged helix" DNA-binding domain0.0000000000005252Direct
Neurotransmitter-gated ion-channel transmembrane pore0.00000000001015Direct
Skp1 dimerisation domain-like0.00000000003079Direct
PH domain-like0.00000000006307Direct
WD40 repeat-like0.0000000001428Direct
Translation proteins0.000002261Direct
GroEL apical domain-like0.000002434Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.000004587Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0.000005183Direct
Translation proteins SH3-like domain0.000005419Direct
SNARE-like0.000007662Direct
t-snare proteins0.000009752Direct
GroEL equatorial domain-like0.000009752Direct
GroEL-intermediate domain like0.000009752Direct
SH3-domain0.00004556Direct
Calponin-homology domain, CH-domain0.00005362Direct
Actin-like ATPase domain0.00007444Direct
ENTH/VHS domain0.00009238Direct
Tubulin C-terminal domain-like0.0002212Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0002563Direct
Lamin A/C globular tail domain0.0002942Direct
Spectrin repeat0.0002942Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0002942Direct
FYVE/PHD zinc finger0.0003483Direct
Sec1/munc18-like (SM) proteins0.0005944Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0.0005944Direct
Tubulin nucleotide-binding domain-like0.0006205Direct
DNA/RNA polymerases0.0007532Direct
Prefoldin0.0008905Direct
Class II aaRS ABD-related0.0008905Direct
Calpain large subunit, middle domain (domain III)0.0008905Direct
PIN domain-like0.0008905Direct
Activating enzymes of the ubiquitin-like proteins0.0008905Direct
RNA-binding domain, RBD0.001298Inherited
HLH, helix-loop-helix DNA-binding domain0.00145Inherited
Cyclin-like0.002165Inherited
Frizzled cysteine-rich domain0.002279Inherited
CAD & PB1 domains0.002279Inherited
Ribosomal proteins S24e, L23 and L15e0.002279Inherited
F1F0 ATP synthase subunit C0.002279Inherited
DBL homology domain (DH-domain)0.002546Inherited
Sm-like ribonucleoproteins0.002546Inherited
Intermediate filament protein, coiled coil region0.002572Inherited
L30e-like0.002942Inherited
DEATH domain0.002942Inherited
Cullin repeat-like0.002942Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.003346Inherited
Ribosomal protein S5 domain 2-like0.004198Inherited
Nucleotidylyl transferase0.004639Inherited
BAR/IMD domain-like0.004639Inherited
GTPase activation domain, GAP0.004729Inherited
Calcium ATPase, transmembrane domain M0.005548Inherited
Hedgehog/intein (Hint) domain0.007274Inherited
Calcium ATPase, transduction domain A0.007602Inherited
Class II aaRS and biotin synthetases0.007602Inherited
Integrin domains0.008544Inherited
Terpenoid cyclases/Protein prenyltransferases0.008544Inherited
Cdc48 domain 2-like0.008544Inherited
post-AAA+ oligomerization domain-like0.008544Inherited
ADC-like0.008544Inherited
BEACH domain0.008544Inherited
beta-sandwich domain of Sec23/240.008544Inherited
TPR-like0.008871Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.009799Inherited
Lipovitellin-phosvitin complex, superhelical domain0.009799Inherited
Di-copper centre-containing domain0.009799Inherited
Translational machinery components0.009799Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.009799Inherited
Hect, E3 ligase catalytic domain0.01959Inherited
YWTD domain0.02523Inherited
Invertebrate chitin-binding proteins0.02677Inherited
Tubby C-terminal domain-like0.03071Inherited
S15/NS1 RNA-binding domain0.03071Inherited
Caspase-like0.03071Inherited
Cupredoxins0.03071Inherited
Fibronectin type III0.04044Inherited
Quinoprotein alcohol dehydrogenase-like0.04976Inherited
Protein kinase-like (PK-like)0.06131Inherited
Homeodomain-like0.06498Inherited
PLC-like phosphodiesterases0.06651Inherited
cAMP-binding domain-like0.06651Inherited
Second domain of FERM0.06866Inherited
Chromo domain-like0.0689Inherited
Cysteine-rich domain0.07715Inherited
HAD-like0.07791Inherited
Myosin rod fragments0.08541Inherited
SET domain0.139Inherited
Growth factor receptor domain0.1407Inherited
CCCH zinc finger0.1718Inherited
p53-like transcription factors0.2052Inherited
Multidrug efflux transporter AcrB transmembrane domain0.2234Inherited
SH2 domain0.2374Inherited
PDZ domain-like0.3339Inherited
Cysteine proteinases0.389Inherited
BRCT domain0.3916Inherited
Transducin (alpha subunit), insertion domain0.4118Inherited
ABC transporter transmembrane region0.4511Inherited
HSP20-like chaperones0.4633Inherited
E set domains0.5208Inherited
PLP-dependent transferases0.6046Inherited
Lipocalins0.6103Inherited
EF-hand0.6354Inherited
Immunoglobulin0.6481Inherited
POZ domain0.762Inherited
RING/U-box0.8391Inherited
Voltage-gated potassium channels0.9124Inherited
Metallo-dependent phosphatases0.9579Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.9733Inherited
Saposin1Inherited
(Phosphotyrosine protein) phosphatases II1Inherited
Thioredoxin-like1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Lesion bypass DNA polymerase (Y-family), catalytic domain0Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
LEM domain0Direct
Zn-finger domain of Sec23/240Direct
DEATH domain, DD0Direct
DNA repair protein MutS, domain III0Direct
Arginine methyltransferase0Direct
Cell cycle transcription factor e2f-dp0Direct
Clathrin adaptor core protein0Direct
RNA-polymerase beta0Direct
Trunk domain of Sec23/240Direct
L30e/L7ae ribosomal proteins0Direct
Acyl-carrier protein (ACP)0Direct
Integrin domains0Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0Direct
Sec7 domain0Direct
14-3-3 protein0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
beta-sandwich domain of Sec23/240Direct
HSP90 C-terminal domain0Direct
Hsp90 middle domain0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Cullin homology domain0Direct
5' to 3' exonuclease catalytic domain0Direct
Helical domain of Sec23/240Direct
Proteasome subunits0Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Clathrin coat assembly domain0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
Type II DNA topoisomerase0Direct
Myotubularin-like phosphatases0Direct
Cullin repeat0Direct
Ribosomal protein S100Direct
Protein prenyltransferases0Direct
PX domain0Direct
Profilin (actin-binding protein)0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
Mammalian PLC0Direct
ValRS/IleRS/LeuRS editing domain0Direct
SCF ubiquitin ligase complex WHB domain0Direct
DLC0Direct
Smc hinge domain0Direct
Nucleosome core histones0.000000000000002197Direct
Skp1 dimerisation domain-like0.00000000004404Direct
Nicotinic receptor ligand binding domain-like0.0000000001064Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0000000004669Direct
FYVE, a phosphatidylinositol-3-phosphate binding domain0.00000002138Direct
Extended AAA-ATPase domain0.0000002138Direct
WD40-repeat0.0000008894Direct
Actin/HSP700.000001222Direct
Pleckstrin-homology domain (PH domain)0.000001394Direct
G proteins0.00001603Direct
Armadillo repeat0.00002472Direct
Group II chaperonin (CCT, TRIC), apical domain0.00003343Direct
t-snare proteins0.00003343Direct
Pumilio repeat0.00007669Direct
PLC-like (P variant)0.00007669Direct
Group II chaperonin (CCT, TRIC), ATPase domain0.0001125Direct
Translational machinery components0.0001125Direct
Phosphotyrosine-binding domain (PTB)0.000114Direct
Motor proteins0.0003927Direct
Calponin-homology domain, CH-domain0.000453Direct
Cold shock DNA-binding domain-like0.0007019Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0007067Direct
Tubulin, C-terminal domain0.0009583Direct
SH3-domain0.0009658Direct
Sec1/munc18-like (SM) proteins0.001241Inherited
RecA protein-like (ATPase-domain)0.001241Inherited
Tandem AAA-ATPase domain0.001781Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.002057Inherited
Elongation factors0.002057Inherited
Calpain large subunit, middle domain (domain III)0.0021Inherited
Tubulin, GTPase domain0.002299Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.002504Inherited
Spectrin repeat0.002504Inherited
BTB/POZ domain0.003491Inherited
Ubiquitin activating enzymes (UBA)0.004094Inherited
F1F0 ATP synthase subunit C0.004094Inherited
EF-hand modules in multidomain proteins0.004094Inherited
BAR domain0.004094Inherited
Frizzled cysteine-rich domain0.004094Inherited
Canonical RBD0.005738Inherited
Prefoldin0.00609Inherited
Intermediate filament protein, coiled coil region0.006531Inherited
Cyclin0.008567Inherited
DBL homology domain (DH-domain)0.008567Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.008567Inherited
HLH, helix-loop-helix DNA-binding domain0.009354Inherited
Hemocyanin middle domain0.01331Inherited
Caspase catalytic domain0.01331Inherited
Ubiquitin carboxyl-terminal hydrolase UCH-L0.01331Inherited
BEACH domain0.01331Inherited
DNA polymerase III clamp loader subunits, C-terminal domain0.01331Inherited
Anticodon-binding domain0.01331Inherited
Cdc48 N-terminal domain-like0.01331Inherited
Cdc48 domain 2-like0.01331Inherited
Ephrin ectodomain0.01331Inherited
Anticodon-binding domain of Class II aaRS0.01331Inherited
I set domains0.01464Inherited
LIM domain0.01591Inherited
Hedgehog C-terminal (Hog) autoprocessing domain0.01591Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.01719Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.01719Inherited
Lipovitellin-phosvitin complex, superhelical domain0.01719Inherited
Calcium ATPase, transduction domain A0.02341Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP0.02623Inherited
Histone lysine methyltransferases0.02895Inherited
Nitrogenase iron protein-like0.03154Inherited
Hect, E3 ligase catalytic domain0.03735Inherited
Erythroid transcription factor GATA-10.03735Inherited
Linker histone H1/H50.0431Inherited
DNA polymerase I0.0431Inherited
FAD/NAD-linked reductases, N-terminal and central domains0.04418Inherited
DEP domain0.04695Inherited
BCR-homology GTPase activation domain (BH-domain)0.04911Inherited
cAMP-binding domain0.08598Inherited
PDZ domain0.08652Inherited
DnaQ-like 3'-5' exonuclease0.09995Inherited
Second domain of FERM0.09995Inherited
YWTD domain0.1019Inherited
Class II glutamine amidotransferases0.1019Inherited
First domain of FERM0.1019Inherited
Calpain large subunit, catalytic domain (domain II)0.1256Inherited
Fibronectin type III0.1389Inherited
Fatty acid binding protein-like0.1592Inherited
ABC transporter ATPase domain-like0.1668Inherited
Third domain of FERM0.2025Inherited
Homeodomain0.2187Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.2349Inherited
Multidrug efflux transporter AcrB transmembrane domain0.2792Inherited
CCCH zinc finger0.3318Inherited
Protein kinases, catalytic subunit0.473Inherited
ABC transporter transmembrane region0.5167Inherited
SH2 domain0.5451Inherited
RING finger domain, C3HC40.5577Inherited
Transducin (alpha subunit), insertion domain0.5933Inherited
Glutathione peroxidase-like0.8601Inherited
Voltage-gated potassium channels1Inherited
Glutathione S-transferase (GST), N-terminal domain1Inherited


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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Clathrin adaptor appendage domain0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
14-3-3 protein0Direct
Zn-finger domain of Sec23/240Direct
Ribosomal protein L10-like0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Type II DNA topoisomerase0Direct
RBP11-like subunits of RNA polymerase0Direct
Ribosomal protein S100Direct
ARM repeat0Direct
HSP90 C-terminal domain0Direct
Smc hinge domain0Direct
Restriction endonuclease-like0Direct
DNA repair protein MutS, domain III0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
VPS9 domain0Direct
Sec7 domain0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
PX domain0Direct
DLC0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Histone-fold0Direct
Cullin homology domain0Direct
LEM domain0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Helical domain of Sec23/240Direct
Profilin (actin-binding protein)0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
The spindle assembly checkpoint protein mad20Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
Nicotinic receptor ligand binding domain-like0.0000000000003088Direct
Nucleic acid-binding proteins0.0000000000003149Direct
"Winged helix" DNA-binding domain0.0000000000004118Direct
Neurotransmitter-gated ion-channel transmembrane pore0.000000000007985Direct
Skp1 dimerisation domain-like0.00000000002426Direct
PH domain-like0.00000000004973Direct
WD40 repeat-like0.0000000001127Direct
Translation proteins0.000001826Direct
GroEL apical domain-like0.000001966Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.000003709Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0.000004193Direct
Translation proteins SH3-like domain0.000004385Direct
SNARE-like0.000006203Direct
GroEL-intermediate domain like0.000007893Direct
t-snare proteins0.000007893Direct
GroEL equatorial domain-like0.000007893Direct
SH3-domain0.00003707Direct
Calponin-homology domain, CH-domain0.00004367Direct
Actin-like ATPase domain0.00006065Direct
ENTH/VHS domain0.00007539Direct
Tubulin C-terminal domain-like0.0001809Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0002101Direct
Spectrin repeat0.0002412Direct
Lamin A/C globular tail domain0.0002412Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0002412Direct
FYVE/PHD zinc finger0.0002859Direct
Sec1/munc18-like (SM) proteins0.0004901Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0.0004901Direct
Tubulin nucleotide-binding domain-like0.0005121Direct
DNA/RNA polymerases0.0006228Direct
Activating enzymes of the ubiquitin-like proteins0.0007371Direct
Calpain large subunit, middle domain (domain III)0.0007371Direct
Prefoldin0.0007371Direct
PIN domain-like0.0007371Direct
Class II aaRS ABD-related0.0007371Direct
RNA-binding domain, RBD0.001078Inherited
HLH, helix-loop-helix DNA-binding domain0.001206Inherited
Cyclin-like0.001812Inherited
CAD & PB1 domains0.001909Inherited
F1F0 ATP synthase subunit C0.001909Inherited
Ribosomal proteins S24e, L23 and L15e0.001909Inherited
Frizzled cysteine-rich domain0.001909Inherited
DBL homology domain (DH-domain)0.002137Inherited
Sm-like ribonucleoproteins0.002137Inherited
Intermediate filament protein, coiled coil region0.002159Inherited
DEATH domain0.002474Inherited
Cullin repeat-like0.002474Inherited
L30e-like0.002474Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.002816Inherited
Ribosomal protein S5 domain 2-like0.003543Inherited
BAR/IMD domain-like0.003923Inherited
Nucleotidylyl transferase0.003923Inherited
GTPase activation domain, GAP0.004Inherited
Calcium ATPase, transmembrane domain M0.004702Inherited
Hedgehog/intein (Hint) domain0.006188Inherited
Class II aaRS and biotin synthetases0.006471Inherited
Calcium ATPase, transduction domain A0.006471Inherited
BEACH domain0.007288Inherited
Cdc48 domain 2-like0.007288Inherited
beta-sandwich domain of Sec23/240.007288Inherited
post-AAA+ oligomerization domain-like0.007288Inherited
Terpenoid cyclases/Protein prenyltransferases0.007288Inherited
ADC-like0.007288Inherited
Integrin domains0.007288Inherited
Zinc beta-ribbon0.007514Inherited
TPR-like0.007574Inherited
Di-copper centre-containing domain0.008376Inherited
Translational machinery components0.008376Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.008376Inherited
Lipovitellin-phosvitin complex, superhelical domain0.008376Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.008376Inherited
Hect, E3 ligase catalytic domain0.01698Inherited
YWTD domain0.02198Inherited
Invertebrate chitin-binding proteins0.02335Inherited
Cupredoxins0.02684Inherited
S15/NS1 RNA-binding domain0.02684Inherited
Caspase-like0.02684Inherited
Tubby C-terminal domain-like0.02684Inherited
Fibronectin type III0.03554Inherited
Quinoprotein alcohol dehydrogenase-like0.04392Inherited
Protein kinase-like (PK-like)0.05439Inherited
Homeodomain-like0.05774Inherited
PLC-like phosphodiesterases0.05915Inherited
cAMP-binding domain-like0.05915Inherited
Second domain of FERM0.0611Inherited
Chromo domain-like0.06131Inherited
Cysteine-rich domain0.06885Inherited
HAD-like0.06956Inherited
Myosin rod fragments0.07645Inherited
SET domain0.1263Inherited
Growth factor receptor domain0.128Inherited
CCCH zinc finger0.1571Inherited
p53-like transcription factors0.1888Inherited
Multidrug efflux transporter AcrB transmembrane domain0.2063Inherited
SH2 domain0.2198Inherited
PDZ domain-like0.3134Inherited
Cysteine proteinases0.3674Inherited
BRCT domain0.3698Inherited
Transducin (alpha subunit), insertion domain0.3896Inherited
ABC transporter transmembrane region0.4284Inherited
HSP20-like chaperones0.4404Inherited
E set domains0.4981Inherited
PLP-dependent transferases0.5824Inherited
Lipocalins0.5881Inherited
EF-hand0.6137Inherited
Immunoglobulin0.6265Inherited
POZ domain0.7432Inherited
RING/U-box0.8229Inherited
Voltage-gated potassium channels0.8996Inherited
Metallo-dependent phosphatases0.9471Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.9633Inherited
(Phosphotyrosine protein) phosphatases II1Inherited
Saposin1Inherited
Thioredoxin-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    56672,100879
  • 56672 - DNA/RNA polymerases
  • 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    64356,49447
  • 64356 - SNARE-like
  • 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor
  • 0Direct
    49348,55711
  • 49348 - Clathrin adaptor appendage domain
  • 55711 - Subdomain of clathrin and coatomer appendage domain
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    57863,48403
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    48425,50729
  • 48425 - Sec7 domain
  • 50729 - PH domain-like
  • 0Direct
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.00000000000622Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.000000000007985Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.0000000215Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.000007893Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.000007893Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.00001301Direct
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.000125Direct
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0.000125Direct
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.0001491Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.0001809Direct
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0002013Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0002101Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.0005121Direct
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.001909Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.002068Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.002816Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.003749Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.007288Inherited
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0.007288Inherited
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.007288Inherited
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0.007288Inherited
    52540,48019
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 48019 - post-AAA+ oligomerization domain-like
  • 0.007288Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.007445Inherited
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0.008376Inherited
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0.008376Inherited
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.008376Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.009543Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.02198Inherited
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.02198Inherited
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0.02198Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02652Inherited
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0.02684Inherited
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.03856Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.05915Inherited
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0.06089Inherited
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0.1192Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.1536Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.1536Inherited
    52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0.2361Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.288Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.3896Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.4284Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 1Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0Direct
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.000007893Direct
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.0002101Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0002101Direct
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.001594Inherited
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.008376Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.01282Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.03222Inherited
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.08315Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.1022Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.2037Inherited
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2361Inherited
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0.2361Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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