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Worm Phenotype (WP): cell physiology variant

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Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Variant [WBPhenotype:0000886] <5>
+ 1:   physiology variant [WBPhenotype:0000519] <7>(494|573) (495|248|68)
0:   cell physiology variant [WBPhenotype:0000536] <26>(152|155) (154|66|17)
- 1:   cell division variant [WBPhenotype:0000746] <20>(55|56) (55|24|4)
- 1:   cell homeostasis metabolism variant [WBPhenotype:0000585] <12>(66|61) (66|26|11)
- 1:   muscle cell physiology variant [WBPhenotype:0000990] <7>(18|20) (19|12|4)
- 1:   neuron physiology variant [WBPhenotype:0000991] <7>(4|5) (4|1|0)
- 1:   cell secretion variant [WBPhenotype:0000258] <6>(7|7) (7|0|0)
- 1:   cell cycle variant [WBPhenotype:0000740] <5>(7|10) (8|4|1)
- 1:   calcium mediated signaling variant [WBPhenotype:0002170] <4>(0|0) (0|0|0)
- 1:   germ cell physiology variant [WBPhenotype:0000987] <4>(7|5) (7|0|0)
- 1:   nuclear positioning variant [WBPhenotype:0000511] <4>(12|14) (13|5|1)
- 1:   cell death variant [WBPhenotype:0000729] <3>(58|51) (59|17|5)
- 1:   cell membrane physiology variant [WBPhenotype:0001965] <3>(0|0) (0|0|0)
- 1:   membrane trafficking variant [WBPhenotype:0001833] <3>(4|3) (4|1|0)
- 1:   oocyte physiology variant [WBPhenotype:0001424] <3>(13|14) (15|7|1)
- 1:   endocytic transport variant [WBPhenotype:0001421] <2>(28|26) (29|11|2)
- 1:   epithelial cell physiology variant [WBPhenotype:0000986] <2>(3|3) (3|2|1)
- 1:   vesicle trafficking variant [WBPhenotype:0001752] <2>(1|0) (1|0|0)
- 1:   coelomocyte physiology variant [WBPhenotype:0001423] <1>(7|7) (7|2|0)
- 1:   embryonic cell physiology variant [WBPhenotype:0000763] <1>(13|17) (13|7|0)
- 1:   lysosome homeostasis deficient [WBPhenotype:0001784] <1>(0|0) (0|0|0)
- 1:   lysosome organization biogenesis variant [WBPhenotype:0001430] <1>(3|3) (3|2|2)
- 1:   nuclear division variant [WBPhenotype:0000504] <1>(7|8) (7|4|2)
- 1:   plasma membrane composition variant [WBPhenotype:0002177] <1>(4|1) (4|1|1)
- 1:   cell growth variant [WBPhenotype:0010001](0|0) (0|0|0)
- 1:   gland cell physiology variant [WBPhenotype:0000988](0|0) (0|0|0)
- 1:   marginal cell physiology variant [WBPhenotype:0000989](0|0) (0|0|0)
- 1:   peroxisome physiology variant [WBPhenotype:0001264](0|0) (0|0|0)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
14-3-3 protein0Direct
ARM repeat0Direct
Cullin homology domain0Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
Helical domain of Sec23/240Direct
Sec7 domain0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
Restriction endonuclease-like0Direct
DLC0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Ribosomal protein S100Direct
Zn-finger domain of Sec23/240Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
VPS9 domain0Direct
HSP90 C-terminal domain0Direct
Ribosomal protein L10Direct
Lipovitellin-phosvitin complex, superhelical domain0Direct
Smc hinge domain0Direct
Ribosomal protein L10-like0Direct
Clathrin adaptor appendage domain0Direct
The spindle assembly checkpoint protein mad20Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
Histone-fold0Direct
PX domain0Direct
RBP11-like subunits of RNA polymerase0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Type II DNA topoisomerase0Direct
LEM domain0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Profilin (actin-binding protein)0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
DNA repair protein MutS, domain III0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Nicotinic receptor ligand binding domain-like0.0000000000004561Direct
Nucleic acid-binding proteins0.00000000000149Direct
"Winged helix" DNA-binding domain0.000000000002634Direct
Neurotransmitter-gated ion-channel transmembrane pore0.000000000009662Direct
Skp1 dimerisation domain-like0.00000000006367Direct
PH domain-like0.00000000009245Direct
WD40 repeat-like0.0000000008087Direct
GroEL apical domain-like0.000003556Direct
FYVE/PHD zinc finger0.000005312Direct
Translation proteins SH3-like domain0.000008089Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.000008288Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0.00001109Direct
SNARE-like0.00001169Direct
t-snare proteins0.00001366Direct
GroEL-intermediate domain like0.00001366Direct
GroEL equatorial domain-like0.00001366Direct
Translation proteins0.00002655Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.00002857Direct
SH3-domain0.00003099Direct
Activating enzymes of the ubiquitin-like proteins0.00005245Direct
Calponin-homology domain, CH-domain0.00009089Direct
Actin-like ATPase domain0.0001323Direct
ENTH/VHS domain0.0001338Direct
Cyclin-like0.0002198Direct
HLH, helix-loop-helix DNA-binding domain0.000221Direct
Tubulin C-terminal domain-like0.0003235Direct
Spectrin repeat0.0004004Direct
Lamin A/C globular tail domain0.0004004Direct
Clc chloride channel0.0007434Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0.0007434Direct
Sec1/munc18-like (SM) proteins0.0007434Direct
Ribosomal protein S5 domain 2-like0.0007498Direct
Tubulin nucleotide-binding domain-like0.0008733Direct
DNA/RNA polymerases0.001035Inherited
Class II aaRS ABD-related0.001137Inherited
PIN domain-like0.001137Inherited
Calpain large subunit, middle domain (domain III)0.001137Inherited
Prefoldin0.001137Inherited
RNA-binding domain, RBD0.001468Inherited
Nucleotidylyl transferase0.001985Inherited
Class II aaRS and biotin synthetases0.002674Inherited
F1F0 ATP synthase subunit C0.002733Inherited
CAD & PB1 domains0.002733Inherited
Ribosomal proteins S24e, L23 and L15e0.002733Inherited
Frizzled cysteine-rich domain0.002733Inherited
Intermediate filament protein, coiled coil region0.00331Inherited
Sm-like ribonucleoproteins0.003479Inherited
DBL homology domain (DH-domain)0.003479Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.003694Inherited
Cullin repeat-like0.003694Inherited
L30e-like0.003694Inherited
DEATH domain0.003694Inherited
Protein kinase-like (PK-like)0.004095Inherited
Growth factor receptor domain0.00424Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.00463Inherited
Ubiquitin-like0.005464Inherited
BAR/IMD domain-like0.006569Inherited
GTPase activation domain, GAP0.006771Inherited
TPR-like0.006963Inherited
Calcium ATPase, transmembrane domain M0.007574Inherited
SET domain0.008405Inherited
Hedgehog/intein (Hint) domain0.009007Inherited
beta-sandwich domain of Sec23/240.009846Inherited
ADC-like0.009846Inherited
Integrin domains0.009846Inherited
Cdc48 domain 2-like0.009846Inherited
BEACH domain0.009846Inherited
Cu,Zn superoxide dismutase-like0.009846Inherited
Terpenoid cyclases/Protein prenyltransferases0.009846Inherited
post-AAA+ oligomerization domain-like0.009846Inherited
Calcium ATPase, transduction domain A0.0101Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.01155Inherited
Di-copper centre-containing domain0.01155Inherited
Translational machinery components0.01155Inherited
Quinoprotein alcohol dehydrogenase-like0.02117Inherited
Hect, E3 ligase catalytic domain0.02331Inherited
cAMP-binding domain-like0.02407Inherited
YWTD domain0.02923Inherited
Chromo domain-like0.03162Inherited
Invertebrate chitin-binding proteins0.03222Inherited
Cupredoxins0.03468Inherited
Caspase-like0.03468Inherited
Tubby C-terminal domain-like0.03468Inherited
S15/NS1 RNA-binding domain0.03468Inherited
PLC-like phosphodiesterases0.07784Inherited
Second domain of FERM0.0814Inherited
Myosin rod fragments0.0961Inherited
Cysteine-rich domain0.09638Inherited
Homeodomain-like0.1005Inherited
PDZ domain-like0.1013Inherited
HAD-like0.1029Inherited
FKBP-like0.1409Inherited
CCCH zinc finger0.2005Inherited
p53-like transcription factors0.2376Inherited
UBC-like0.2434Inherited
Multidrug efflux transporter AcrB transmembrane domain0.2594Inherited
SH2 domain0.2912Inherited
CBS-domain pair0.307Inherited
BRCT domain0.4318Inherited
Transducin (alpha subunit), insertion domain0.4464Inherited
Cysteine proteinases0.4647Inherited
HSP20-like chaperones0.4993Inherited
E set domains0.5801Inherited
Immunoglobulin0.6019Inherited
Lipocalins0.6485Inherited
ABC transporter transmembrane region0.6519Inherited
EF-hand0.7112Inherited
PLP-dependent transferases0.7592Inherited
Clavaminate synthase-like0.7839Inherited
RING/U-box0.7907Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.8563Inherited
POZ domain0.8894Inherited
Voltage-gated potassium channels0.9517Inherited
(Phosphotyrosine protein) phosphatases II1Inherited
Metallo-dependent phosphatases1Inherited
Saposin1Inherited
Thioredoxin-like1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Clathrin coat assembly domain0Direct
Cullin repeat0Direct
Trunk domain of Sec23/240Direct
Profilin (actin-binding protein)0Direct
Acyl-carrier protein (ACP)0Direct
beta-sandwich domain of Sec23/240Direct
Cell cycle transcription factor e2f-dp0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Protein prenyltransferases0Direct
Ribosomal protein L10Direct
Helical domain of Sec23/240Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
14-3-3 protein0Direct
Hsp90 middle domain0Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Sec7 domain0Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0Direct
PX domain0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
DNA repair protein MutS, domain III0Direct
Integrin domains0Direct
Type II DNA topoisomerase0Direct
HSP90 C-terminal domain0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
Proteasome subunits0Direct
Ribosomal protein S100Direct
5' to 3' exonuclease catalytic domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
Lipovitellin-phosvitin complex, superhelical domain0Direct
Smc hinge domain0Direct
DNA gyrase/MutL, second domain0Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0Direct
Cullin homology domain0Direct
RNA-polymerase beta0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Arginine methyltransferase0Direct
LEM domain0Direct
Lesion bypass DNA polymerase (Y-family), catalytic domain0Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
Myotubularin-like phosphatases0Direct
Mammalian PLC0Direct
Clathrin adaptor core protein0Direct
Ubiquitin activating enzymes (UBA)0Direct
DEATH domain, DD0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
DLC0Direct
SCF ubiquitin ligase complex WHB domain0Direct
L30e/L7ae ribosomal proteins0Direct
Zn-finger domain of Sec23/240Direct
Nucleosome core histones0.00000000000001353Direct
Skp1 dimerisation domain-like0.0000000000965Direct
Nicotinic receptor ligand binding domain-like0.0000000001353Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0000000005299Direct
FYVE, a phosphatidylinositol-3-phosphate binding domain0.00000003869Direct
WD40-repeat0.000001307Direct
Actin/HSP700.000002368Direct
Extended AAA-ATPase domain0.000002602Direct
Pleckstrin-homology domain (PH domain)0.000003094Direct
Armadillo repeat0.0000376Direct
t-snare proteins0.00004782Direct
Group II chaperonin (CCT, TRIC), apical domain0.00004782Direct
PLC-like (P variant)0.0001122Direct
Translational machinery components0.0001547Direct
Group II chaperonin (CCT, TRIC), ATPase domain0.0001547Direct
Phosphotyrosine-binding domain (PTB)0.0001702Direct
G proteins0.0002429Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0003296Direct
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.0006015Direct
Cyclin0.0006015Direct
Motor proteins0.0007163Direct
Calponin-homology domain, CH-domain0.0007661Direct
SH3-domain0.0007934Direct
Tandem AAA-ATPase domain0.0008456Direct
Cold shock DNA-binding domain-like0.001104Inherited
Pumilio repeat0.001252Inherited
Tubulin, C-terminal domain0.001411Inherited
RecA protein-like (ATPase-domain)0.001569Inherited
Clc chloride channel0.001569Inherited
Sec1/munc18-like (SM) proteins0.001569Inherited
HLH, helix-loop-helix DNA-binding domain0.002155Inherited
Calpain large subunit, middle domain (domain III)0.002711Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.002974Inherited
Histone lysine methyltransferases0.002974Inherited
Tubulin, GTPase domain0.003248Inherited
Spectrin repeat0.003304Inherited
F1F0 ATP synthase subunit C0.004962Inherited
Frizzled cysteine-rich domain0.004962Inherited
BAR domain0.004962Inherited
EF-hand modules in multidomain proteins0.004962Inherited
BTB/POZ domain0.006485Inherited
Canonical RBD0.006485Inherited
Prefoldin0.007539Inherited
Intermediate filament protein, coiled coil region0.008459Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.008464Inherited
Elongation factors0.01172Inherited
DBL homology domain (DH-domain)0.01172Inherited
Tetratricopeptide repeat (TPR)0.01199Inherited
DNA polymerase III clamp loader subunits, C-terminal domain0.01542Inherited
BEACH domain0.01542Inherited
Hemocyanin middle domain0.01542Inherited
Cdc48 N-terminal domain-like0.01542Inherited
Cdc48 domain 2-like0.01542Inherited
Ubiquitin carboxyl-terminal hydrolase UCH-L0.01542Inherited
Anticodon-binding domain0.01542Inherited
Anticodon-binding domain of Class II aaRS0.01542Inherited
Ephrin ectodomain0.01542Inherited
Cu,Zn superoxide dismutase-like0.01542Inherited
Caspase catalytic domain0.01542Inherited
DNA gyrase/MutL, N-terminal domain0.01542Inherited
FAD/NAD-linked reductases, N-terminal and central domains0.01569Inherited
PDZ domain0.01783Inherited
I set domains0.01966Inherited
LIM domain0.01979Inherited
Hedgehog C-terminal (Hog) autoprocessing domain0.01979Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.02041Inherited
Calcium ATPase, transduction domain A0.03102Inherited
cAMP-binding domain0.03289Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP0.03289Inherited
Nitrogenase iron protein-like0.03852Inherited
Erythroid transcription factor GATA-10.04459Inherited
Hect, E3 ligase catalytic domain0.04459Inherited
DNA polymerase I0.05029Inherited
Linker histone H1/H50.05029Inherited
DEP domain0.05352Inherited
BCR-homology GTPase activation domain (BH-domain)0.0631Inherited
Growth factor receptor domain0.08334Inherited
Protein kinases, catalytic subunit0.1093Inherited
Class II glutamine amidotransferases0.1143Inherited
First domain of FERM0.1143Inherited
YWTD domain0.1143Inherited
Second domain of FERM0.1197Inherited
DnaQ-like 3'-5' exonuclease0.1197Inherited
Calpain large subunit, catalytic domain (domain II)0.1473Inherited
Fatty acid binding protein-like0.1822Inherited
Homeodomain0.2157Inherited
PHD domain0.216Inherited
FKBP immunophilin/proline isomerase0.2215Inherited
Third domain of FERM0.226Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.2728Inherited
ABC transporter ATPase domain-like0.3117Inherited
Multidrug efflux transporter AcrB transmembrane domain0.3267Inherited
CCCH zinc finger0.381Inherited
CBS-domain pair0.3876Inherited
RING finger domain, C3HC40.6209Inherited
SH2 domain0.622Inherited
Transducin (alpha subunit), insertion domain0.6377Inherited
UBC-related0.7229Inherited
ABC transporter transmembrane region0.7278Inherited
Glutathione peroxidase-like0.8916Inherited
Glutathione S-transferase (GST), N-terminal domain1Inherited
Voltage-gated potassium channels1Inherited


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Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Lipovitellin-phosvitin complex, superhelical domain0Direct
DNA repair protein MutS, domain III0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Restriction endonuclease-like0Direct
Ribosomal protein L10Direct
RBP11-like subunits of RNA polymerase0Direct
Type II DNA topoisomerase0Direct
Profilin (actin-binding protein)0Direct
Zn-finger domain of Sec23/240Direct
ValRS/IleRS/LeuRS editing domain0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
LEM domain0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
PX domain0Direct
Helical domain of Sec23/240Direct
Histone-fold0Direct
DLC0Direct
Cullin homology domain0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
14-3-3 protein0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Smc hinge domain0Direct
Ribosomal protein S100Direct
Clathrin adaptor appendage domain0Direct
Ribosomal protein L10-like0Direct
VPS9 domain0Direct
Sec7 domain0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
The spindle assembly checkpoint protein mad20Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
ARM repeat0Direct
HSP90 C-terminal domain0Direct
Nicotinic receptor ligand binding domain-like0.0000000000003556Direct
Nucleic acid-binding proteins0.000000000001163Direct
"Winged helix" DNA-binding domain0.000000000002059Direct
Neurotransmitter-gated ion-channel transmembrane pore0.000000000007564Direct
Skp1 dimerisation domain-like0.00000000004996Direct
PH domain-like0.00000000007258Direct
WD40 repeat-like0.0000000006371Direct
GroEL apical domain-like0.000002866Direct
FYVE/PHD zinc finger0.000004284Direct
Translation proteins SH3-like domain0.00000653Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.000006693Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0.000008962Direct
SNARE-like0.000009455Direct
GroEL equatorial domain-like0.00001106Direct
t-snare proteins0.00001106Direct
GroEL-intermediate domain like0.00001106Direct
Translation proteins0.00002153Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.00002318Direct
SH3-domain0.00002514Direct
Activating enzymes of the ubiquitin-like proteins0.00004265Direct
Calponin-homology domain, CH-domain0.00007405Direct
Actin-like ATPase domain0.0001079Direct
ENTH/VHS domain0.0001092Direct
Cyclin-like0.0001796Direct
HLH, helix-loop-helix DNA-binding domain0.0001805Direct
Tubulin C-terminal domain-like0.0002651Direct
Lamin A/C globular tail domain0.0003287Direct
Spectrin repeat0.0003287Direct
Sec1/munc18-like (SM) proteins0.0006134Direct
Clc chloride channel0.0006134Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0.0006134Direct
Ribosomal protein S5 domain 2-like0.0006187Direct
Tubulin nucleotide-binding domain-like0.0007216Direct
DNA/RNA polymerases0.000856Direct
Class II aaRS ABD-related0.0009414Direct
PIN domain-like0.0009414Direct
Calpain large subunit, middle domain (domain III)0.0009414Direct
Prefoldin0.0009414Direct
RNA-binding domain, RBD0.001219Inherited
Nucleotidylyl transferase0.001654Inherited
Class II aaRS and biotin synthetases0.002239Inherited
CAD & PB1 domains0.00229Inherited
Frizzled cysteine-rich domain0.00229Inherited
Ribosomal proteins S24e, L23 and L15e0.00229Inherited
F1F0 ATP synthase subunit C0.00229Inherited
Intermediate filament protein, coiled coil region0.002783Inherited
DBL homology domain (DH-domain)0.002925Inherited
Sm-like ribonucleoproteins0.002925Inherited
L30e-like0.003109Inherited
DEATH domain0.003109Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.003109Inherited
Cullin repeat-like0.003109Inherited
Protein kinase-like (PK-like)0.00345Inherited
Growth factor receptor domain0.003576Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.003906Inherited
Ubiquitin-like0.004618Inherited
BAR/IMD domain-like0.005564Inherited
GTPase activation domain, GAP0.005739Inherited
TPR-like0.005906Inherited
Calcium ATPase, transmembrane domain M0.006432Inherited
SET domain0.007153Inherited
Hedgehog/intein (Hint) domain0.007674Inherited
Cu,Zn superoxide dismutase-like0.008399Inherited
Terpenoid cyclases/Protein prenyltransferases0.008399Inherited
Cdc48 domain 2-like0.008399Inherited
ADC-like0.008399Inherited
Integrin domains0.008399Inherited
post-AAA+ oligomerization domain-like0.008399Inherited
BEACH domain0.008399Inherited
beta-sandwich domain of Sec23/240.008399Inherited
Calcium ATPase, transduction domain A0.008621Inherited
Zinc beta-ribbon0.009097Inherited
Translational machinery components0.009887Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.009887Inherited
Di-copper centre-containing domain0.009887Inherited
Quinoprotein alcohol dehydrogenase-like0.01834Inherited
Hect, E3 ligase catalytic domain0.02024Inherited
cAMP-binding domain-like0.02092Inherited
YWTD domain0.02553Inherited
Chromo domain-like0.02764Inherited
Invertebrate chitin-binding proteins0.02818Inherited
Cupredoxins0.03037Inherited
S15/NS1 RNA-binding domain0.03037Inherited
Tubby C-terminal domain-like0.03037Inherited
Caspase-like0.03037Inherited
Nucleotide-diphospho-sugar transferases0.03929Inherited
PLC-like phosphodiesterases0.06953Inherited
Second domain of FERM0.07283Inherited
Myosin rod fragments0.08644Inherited
Cysteine-rich domain0.08671Inherited
Homeodomain-like0.0905Inherited
PDZ domain-like0.0913Inherited
HAD-like0.09271Inherited
FKBP-like0.1282Inherited
CCCH zinc finger0.1842Inherited
p53-like transcription factors0.2199Inherited
UBC-like0.2255Inherited
Multidrug efflux transporter AcrB transmembrane domain0.2408Inherited
SH2 domain0.2718Inherited
CBS-domain pair0.2874Inherited
BRCT domain0.4098Inherited
Transducin (alpha subunit), insertion domain0.4244Inherited
Cysteine proteinases0.4428Inherited
HSP20-like chaperones0.4773Inherited
E set domains0.5576Inherited
Immunoglobulin0.5796Inherited
Lipocalins0.6263Inherited
ABC transporter transmembrane region0.6299Inherited
EF-hand0.691Inherited
PLP-dependent transferases0.7402Inherited
Clavaminate synthase-like0.7656Inherited
RING/U-box0.7728Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.8405Inherited
POZ domain0.8747Inherited
Voltage-gated potassium channels0.9399Inherited
Metallo-dependent phosphatases1Inherited
Thioredoxin-like1Inherited
(Phosphotyrosine protein) phosphatases II1Inherited
Saposin1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0Direct
    57863,48403
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0Direct
    64356,49447
  • 64356 - SNARE-like
  • 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor
  • 0Direct
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    56672,100879
  • 56672 - DNA/RNA polymerases
  • 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain
  • 0Direct
    49348,55711
  • 49348 - Clathrin adaptor appendage domain
  • 55711 - Subdomain of clathrin and coatomer appendage domain
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    48425,50729
  • 48425 - Sec7 domain
  • 50729 - PH domain-like
  • 0Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.000000000007564Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.00000000001251Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.00000003701Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.00001106Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.00001106Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.00002347Direct
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.00003745Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.0001092Direct
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.0001627Direct
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0.0001627Direct
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.0002239Direct
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.0007215Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.0007216Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.001524Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.00229Inherited
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0.003102Inherited
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.003109Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.003906Inherited
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0.008399Inherited
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0.008399Inherited
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.008399Inherited
    52540,48019
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 48019 - post-AAA+ oligomerization domain-like
  • 0.008399Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.008399Inherited
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0.009887Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.01006Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.01198Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.01937Inherited
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.02553Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.02553Inherited
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0.03037Inherited
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0.03037Inherited
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.04593Inherited
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0.06803Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.06953Inherited
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0.135Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.1748Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.1748Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.211Inherited
    52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0.255Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.4244Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.6299Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 1Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.00001106Direct
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.0002797Direct
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.002239Inherited
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.003109Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.01566Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.03787Inherited
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.09532Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.1223Inherited
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.255Inherited
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0.255Inherited


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