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Worm Phenotype (WP): cell physiology variant

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Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Variant [WBPhenotype:0000886] <2>
+ 1:   physiology variant [WBPhenotype:0000519] <14>(510|587) (510|248|69)
0:   cell physiology variant [WBPhenotype:0000536] <36>(149|149) (150|64|19)
- 1:   cell division variant [WBPhenotype:0000746] <19>(51|54) (52|20|4)
- 1:   cell homeostasis metabolism variant [WBPhenotype:0000585] <12>(60|54) (60|23|12)
- 1:   neuron physiology variant [WBPhenotype:0000991] <10>(3|4) (3|1|0)
- 1:   muscle cell physiology variant [WBPhenotype:0000990] <8>(21|22) (22|13|4)
- 1:   cell cycle variant [WBPhenotype:0000740] <6>(35|35) (35|17|4)
- 1:   cell secretion variant [WBPhenotype:0000258] <6>(7|8) (7|1|0)
- 1:   germ cell physiology variant [WBPhenotype:0000987] <6>(28|19) (29|8|1)
- 1:   calcium mediated signaling variant [WBPhenotype:0002170] <5>(0|0) (0|0|0)
- 1:   nuclear positioning variant [WBPhenotype:0000511] <5>(12|14) (13|5|1)
- 1:   epithelial cell physiology variant [WBPhenotype:0000986] <4>(3|3) (3|2|1)
- 1:   cell death variant [WBPhenotype:0000729] <3>(58|51) (58|15|5)
- 1:   cell membrane physiology variant [WBPhenotype:0001965] <3>(0|0) (0|0|0)
- 1:   membrane trafficking variant [WBPhenotype:0001833] <3>(4|3) (4|1|0)
- 1:   coelomocyte physiology variant [WBPhenotype:0001423] <2>(7|7) (7|2|0)
- 1:   vesicle trafficking variant [WBPhenotype:0001752] <2>(31|26) (32|10|2)
- 1:   P lineages variant [WBPhenotype:0000099] <1>(2|2) (2|0|0)
- 1:   accessory cell physiology variant [WBPhenotype:0000974] <1>(0|0) (0|0|0)
- 1:   embryonic cell physiology variant [WBPhenotype:0000763] <1>(12|17) (13|6|0)
- 1:   lysosome homeostasis deficient [WBPhenotype:0001784] <1>(0|0) (0|0|0)
- 1:   lysosome organization biogenesis variant [WBPhenotype:0001430] <1>(3|3) (3|2|2)
- 1:   nuclear division variant [WBPhenotype:0000504] <1>(7|8) (7|4|2)
- 1:   plasma membrane composition variant [WBPhenotype:0002177] <1>(4|1) (4|1|1)
- 1:   AB lineage variant [WBPhenotype:0000097](0|0) (0|0|0)
- 1:   B lineage variant [WBPhenotype:0000830](0|0) (0|0|0)
- 1:   C lineage variant [WBPhenotype:0000832](0|0) (0|0|0)
- 1:   D lineage variant [WBPhenotype:0000935](0|0) (0|0|0)
- 1:   E lineage variant [WBPhenotype:0000834](0|0) (0|0|0)
- 1:   M lineage variant [WBPhenotype:0000095](1|1) (1|0|0)
- 1:   MS lineage variant [WBPhenotype:0000933](0|0) (0|0|0)
- 1:   Q lineage variant [WBPhenotype:0000829](0|0) (0|0|0)
- 1:   blast cell physiology variant [WBPhenotype:0000985](0|0) (0|0|0)
- 1:   cell growth variant [WBPhenotype:0010001](0|0) (0|0|0)
- 1:   centrosome dynamics variant [WBPhenotype:0002074](0|0) (0|0|0)
- 1:   gland cell physiology variant [WBPhenotype:0000988](0|0) (0|0|0)
- 1:   intestinal cell proliferation variant [WBPhenotype:0000092](0|0) (0|0|0)
- 1:   peroxisome physiology variant [WBPhenotype:0001264](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Helical domain of Sec23/240Direct
LEM domain0Direct
Histone-fold0Direct
Sec7 domain0Direct
RBP11-like subunits of RNA polymerase0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
The spindle assembly checkpoint protein mad20Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Heme-dependent catalase-like0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Restriction endonuclease-like0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Smc hinge domain0Direct
Sec1/munc18-like (SM) proteins0Direct
Profilin (actin-binding protein)0Direct
Cullin homology domain0Direct
DLC0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Zn-finger domain of Sec23/240Direct
HRDC-like0Direct
HSP90 C-terminal domain0Direct
DNA repair protein MutS, domain III0Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
Clathrin adaptor appendage domain0Direct
14-3-3 protein0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
VPS9 domain0Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
ARM repeat0Direct
PX domain0Direct
Lipovitellin-phosvitin complex, superhelical domain0Direct
Ribosomal protein S100Direct
Ribosomal protein L10-like0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
"Winged helix" DNA-binding domain0.0000000000002117Direct
Nucleic acid-binding proteins0.0000000000002298Direct
Nicotinic receptor ligand binding domain-like0.000000000003309Direct
Skp1 dimerisation domain-like0.00000000006632Direct
Neurotransmitter-gated ion-channel transmembrane pore0.00000000006657Direct
PH domain-like0.0000000001054Direct
WD40 repeat-like0.000000001363Direct
FYVE/PHD zinc finger0.0000004235Direct
RNA-binding domain, RBD0.000001412Direct
GroEL apical domain-like0.00000358Direct
Translation proteins SH3-like domain0.000008161Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.000008518Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0.00001158Direct
SNARE-like0.00001184Direct
t-snare proteins0.00001375Direct
GroEL equatorial domain-like0.00001375Direct
GroEL-intermediate domain like0.00001375Direct
Arginase/deacetylase0.00001375Direct
SH3-domain0.00003252Direct
DNA/RNA polymerases0.00003911Direct
Class II aaRS ABD-related0.00005258Direct
HLH, helix-loop-helix DNA-binding domain0.00006017Direct
Calponin-homology domain, CH-domain0.00009312Direct
ENTH/VHS domain0.000135Direct
Translation proteins0.0001491Direct
Tubulin C-terminal domain-like0.0003274Direct
L30e-like0.0003421Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.000403Direct
Lamin A/C globular tail domain0.000403Direct
Spectrin repeat0.000403Direct
Actin-like ATPase domain0.0004877Direct
TPR-like0.0006835Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0.0007425Direct
Translational machinery components0.0007425Direct
Tubulin nucleotide-binding domain-like0.0008838Direct
Cyclin-like0.0009165Direct
Prefoldin0.001142Inherited
Activating enzymes of the ubiquitin-like proteins0.001142Inherited
PIN domain-like0.001142Inherited
Calpain large subunit, middle domain (domain III)0.001142Inherited
Class II aaRS and biotin synthetases0.002709Inherited
Ribosomal proteins S24e, L23 and L15e0.002727Inherited
F1F0 ATP synthase subunit C0.002727Inherited
Frizzled cysteine-rich domain0.002727Inherited
Intermediate filament protein, coiled coil region0.003333Inherited
Tropomyosin0.003333Inherited
DBL homology domain (DH-domain)0.003523Inherited
Sm-like ribonucleoproteins0.003523Inherited
Zn-binding ribosomal proteins0.003699Inherited
DHS-like NAD/FAD-binding domain0.003718Inherited
Cullin repeat-like0.003718Inherited
DEATH domain0.003718Inherited
Ribosomal protein S5 domain 2-like0.004545Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.004685Inherited
SET domain0.006042Inherited
Ubiquitin-like0.006429Inherited
BAR/IMD domain-like0.006659Inherited
GTPase activation domain, GAP0.007431Inherited
Calcium ATPase, transmembrane domain M0.007657Inherited
Hedgehog/intein (Hint) domain0.009021Inherited
BEACH domain0.009801Inherited
ADC-like0.009801Inherited
Cdc48 domain 2-like0.009801Inherited
Integrin domains0.009801Inherited
beta-sandwich domain of Sec23/240.009801Inherited
Terpenoid cyclases/Protein prenyltransferases0.009801Inherited
post-AAA+ oligomerization domain-like0.009801Inherited
Calcium ATPase, transduction domain A0.0102Inherited
Di-copper centre-containing domain0.01153Inherited
Protein kinase-like (PK-like)0.01221Inherited
Nucleotidylyl transferase0.01324Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.02335Inherited
Hect, E3 ligase catalytic domain0.02335Inherited
Homeodomain-like0.02346Inherited
YWTD domain0.02928Inherited
Chromo domain-like0.03186Inherited
Invertebrate chitin-binding proteins0.03233Inherited
Tubby C-terminal domain-like0.0347Inherited
CAD & PB1 domains0.0347Inherited
Cupredoxins0.0347Inherited
S15/NS1 RNA-binding domain0.0347Inherited
Caspase-like0.0347Inherited
Growth factor receptor domain0.03541Inherited
Cysteine-rich domain0.04747Inherited
PLC-like phosphodiesterases0.05219Inherited
Quinoprotein alcohol dehydrogenase-like0.06104Inherited
cAMP-binding domain-like0.07818Inherited
Second domain of FERM0.08196Inherited
Myosin rod fragments0.09622Inherited
EGF/Laminin0.1063Inherited
p53-like transcription factors0.1305Inherited
PDZ domain-like0.163Inherited
BRCT domain0.1751Inherited
CCCH zinc finger0.2016Inherited
HAD-like0.2594Inherited
Multidrug efflux transporter AcrB transmembrane domain0.2602Inherited
SH2 domain0.2672Inherited
PLP-dependent transferases0.3685Inherited
Cysteine proteinases0.3935Inherited
beta-beta-alpha zinc fingers0.4026Inherited
Transducin (alpha subunit), insertion domain0.4454Inherited
HSP20-like chaperones0.4982Inherited
Clavaminate synthase-like0.5975Inherited
EF-hand0.6145Inherited
RING/U-box0.6351Inherited
ABC transporter transmembrane region0.6495Inherited
POZ domain0.6869Inherited
Immunoglobulin0.7123Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.9175Inherited
Voltage-gated potassium channels0.9542Inherited
(Phosphotyrosine protein) phosphatases II1Inherited
Saposin1Inherited
Metallo-dependent phosphatases1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Profilin (actin-binding protein)0Direct
Trunk domain of Sec23/240Direct
Cell cycle transcription factor e2f-dp0Direct
Integrin domains0Direct
DEATH domain, DD0Direct
Lipovitellin-phosvitin complex, superhelical domain0Direct
LEM domain0Direct
Acyl-carrier protein (ACP)0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Hsp90 middle domain0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Helical domain of Sec23/240Direct
5' to 3' exonuclease catalytic domain0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
HSP90 C-terminal domain0Direct
beta-sandwich domain of Sec23/240Direct
Cullin repeat0Direct
Lesion bypass DNA polymerase (Y-family), catalytic domain0Direct
L30e/L7ae ribosomal proteins0Direct
Smc hinge domain0Direct
Ribosomal protein S100Direct
Mammalian PLC0Direct
Sec1/munc18-like (SM) proteins0Direct
SCF ubiquitin ligase complex WHB domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
DLC0Direct
Clathrin coat assembly domain0Direct
RNA-polymerase beta0Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
PX domain0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0Direct
Sir2 family of transcriptional regulators0Direct
Myotubularin-like phosphatases0Direct
Proteasome subunits0Direct
14-3-3 protein0Direct
Sec7 domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
MIF4G domain-like0Direct
DNA repair protein MutS, domain III0Direct
Clathrin adaptor core protein0Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
Arginine methyltransferase0Direct
Heme-dependent catalases0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Brix domain0Direct
Histone deacetylase, HDAC0Direct
Cullin homology domain0Direct
Protein prenyltransferases0Direct
Laminin-type module0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
Zn-finger domain of Sec23/240Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Nucleosome core histones0.00000000000001031Direct
Skp1 dimerisation domain-like0.00000000008484Direct
Nicotinic receptor ligand binding domain-like0.0000000005616Direct
Neurotransmitter-gated ion-channel transmembrane pore0.000000001708Direct
FYVE, a phosphatidylinositol-3-phosphate binding domain0.00000003488Direct
Extended AAA-ATPase domain0.000001071Direct
Actin/HSP700.000002118Direct
Pleckstrin-homology domain (PH domain)0.000002718Direct
WD40-repeat0.000003488Direct
Canonical RBD0.000005875Direct
Armadillo repeat0.00003468Direct
t-snare proteins0.00004445Direct
Group II chaperonin (CCT, TRIC), apical domain0.00004445Direct
PLC-like (P variant)0.000104Direct
Group II chaperonin (CCT, TRIC), ATPase domain0.0001444Direct
Translational machinery components0.0001444Direct
Phosphotyrosine-binding domain (PTB)0.0001572Direct
G proteins0.0002028Direct
Pumilio repeat0.0003067Direct
Motor proteins0.0006458Direct
HLH, helix-loop-helix DNA-binding domain0.0006458Direct
Calponin-homology domain, CH-domain0.0006973Direct
SH3-domain0.0007033Direct
Cold shock DNA-binding domain-like0.001018Inherited
Tandem AAA-ATPase domain0.001022Inherited
Histone lysine methyltransferases0.00131Inherited
Tubulin, C-terminal domain0.00131Inherited
RecA protein-like (ATPase-domain)0.001486Inherited
Calpain large subunit, middle domain (domain III)0.002562Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.00277Inherited
Cyclin0.00277Inherited
Tubulin, GTPase domain0.003032Inherited
Spectrin repeat0.00311Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.00311Inherited
Tetratricopeptide repeat (TPR)0.004466Inherited
BAR domain0.004728Inherited
F1F0 ATP synthase subunit C0.004728Inherited
Ubiquitin activating enzymes (UBA)0.004728Inherited
EF-hand modules in multidomain proteins0.004728Inherited
Frizzled cysteine-rich domain0.004728Inherited
Prefoldin0.007158Inherited
DNA polymerase I0.007158Inherited
BTB/POZ domain0.007673Inherited
Intermediate filament protein, coiled coil region0.007991Inherited
Tropomyosin0.007991Inherited
DBL homology domain (DH-domain)0.011Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.011Inherited
Caspase catalytic domain0.01482Inherited
Ephrin ectodomain0.01482Inherited
Cdc48 N-terminal domain-like0.01482Inherited
Anticodon-binding domain0.01482Inherited
Anticodon-binding domain of Class II aaRS0.01482Inherited
BEACH domain0.01482Inherited
Hemocyanin middle domain0.01482Inherited
Cdc48 domain 2-like0.01482Inherited
DNA polymerase III clamp loader subunits, C-terminal domain0.01482Inherited
I set domains0.01852Inherited
LIM domain0.01884Inherited
Hedgehog C-terminal (Hog) autoprocessing domain0.01884Inherited
Single strand DNA-binding domain, SSB0.01884Inherited
PDZ domain0.02366Inherited
Calcium ATPase, transduction domain A0.02932Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP0.03136Inherited
Elongation factors0.03552Inherited
Nitrogenase iron protein-like0.03687Inherited
Homeodomain0.04193Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.04282Inherited
Hect, E3 ligase catalytic domain0.04282Inherited
DnaQ-like 3'-5' exonuclease0.04301Inherited
PHD domain0.0439Inherited
Linker histone H1/H50.04848Inherited
DEP domain0.05171Inherited
BCR-homology GTPase activation domain (BH-domain)0.06264Inherited
cAMP-binding domain0.09784Inherited
YWTD domain0.1106Inherited
First domain of FERM0.1106Inherited
Class II glutamine amidotransferases0.1106Inherited
Second domain of FERM0.1148Inherited
Calpain large subunit, catalytic domain (domain II)0.1413Inherited
Myosin rod fragments0.1498Inherited
Protein kinases, catalytic subunit0.1919Inherited
Growth factor receptor domain0.193Inherited
Third domain of FERM0.2189Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.2632Inherited
ABC transporter ATPase domain-like0.2802Inherited
Multidrug efflux transporter AcrB transmembrane domain0.3152Inherited
RING finger domain, C3HC40.3428Inherited
CCCH zinc finger0.3685Inherited
SH2 domain0.5671Inherited
Transducin (alpha subunit), insertion domain0.6217Inherited
ABC transporter transmembrane region0.7089Inherited
Protein serine/threonine phosphatase1Inherited
Voltage-gated potassium channels1Inherited


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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
14-3-3 protein0Direct
The spindle assembly checkpoint protein mad20Direct
Cullin homology domain0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
PX domain0Direct
Ribosomal protein S100Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Sec7 domain0Direct
LEM domain0Direct
Histone-fold0Direct
Restriction endonuclease-like0Direct
VPS9 domain0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
DNA repair protein MutS, domain III0Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
HSP90 C-terminal domain0Direct
Sec1/munc18-like (SM) proteins0Direct
Clathrin adaptor appendage domain0Direct
Ribosomal protein L10-like0Direct
Smc hinge domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Lipovitellin-phosvitin complex, superhelical domain0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
Zn-finger domain of Sec23/240Direct
ARM repeat0Direct
HRDC-like0Direct
Heme-dependent catalase-like0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Helical domain of Sec23/240Direct
DLC0Direct
Profilin (actin-binding protein)0Direct
RBP11-like subunits of RNA polymerase0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
"Winged helix" DNA-binding domain0.0000000000001663Direct
Nucleic acid-binding proteins0.0000000000001805Direct
Nicotinic receptor ligand binding domain-like0.000000000002609Direct
Skp1 dimerisation domain-like0.00000000005242Direct
Neurotransmitter-gated ion-channel transmembrane pore0.00000000005262Direct
PH domain-like0.00000000008336Direct
WD40 repeat-like0.000000001082Direct
FYVE/PHD zinc finger0.0000003409Direct
RNA-binding domain, RBD0.000001141Direct
GroEL apical domain-like0.000002905Direct
Translation proteins SH3-like domain0.000006633Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.000006924Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0.000009422Direct
SNARE-like0.000009633Direct
t-snare proteins0.00001119Direct
GroEL equatorial domain-like0.00001119Direct
Arginase/deacetylase0.00001119Direct
GroEL-intermediate domain like0.00001119Direct
SH3-domain0.00002654Direct
DNA/RNA polymerases0.00003194Direct
Class II aaRS ABD-related0.000043Direct
HLH, helix-loop-helix DNA-binding domain0.00004922Direct
Calponin-homology domain, CH-domain0.00007626Direct
ENTH/VHS domain0.0001106Direct
Translation proteins0.0001223Direct
Tubulin C-terminal domain-like0.0002697Direct
L30e-like0.0002819Direct
Spectrin repeat0.0003325Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0003325Direct
Lamin A/C globular tail domain0.0003325Direct
Actin-like ATPase domain0.0004035Direct
TPR-like0.0005667Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0.0006165Direct
Translational machinery components0.0006165Direct
Tubulin nucleotide-binding domain-like0.0007348Direct
Cyclin-like0.0007622Direct
Activating enzymes of the ubiquitin-like proteins0.0009507Direct
Calpain large subunit, middle domain (domain III)0.0009507Direct
Prefoldin0.0009507Direct
PIN domain-like0.0009507Direct
Class II aaRS and biotin synthetases0.002283Inherited
F1F0 ATP synthase subunit C0.002299Inherited
Frizzled cysteine-rich domain0.002299Inherited
Ribosomal proteins S24e, L23 and L15e0.002299Inherited
Tropomyosin0.002816Inherited
Intermediate filament protein, coiled coil region0.002816Inherited
Sm-like ribonucleoproteins0.002979Inherited
DBL homology domain (DH-domain)0.002979Inherited
Zn-binding ribosomal proteins0.00313Inherited
Cullin repeat-like0.003147Inherited
DHS-like NAD/FAD-binding domain0.003147Inherited
DEATH domain0.003147Inherited
Ribosomal protein S5 domain 2-like0.003855Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.003976Inherited
SET domain0.005144Inherited
Ubiquitin-like0.00548Inherited
BAR/IMD domain-like0.005678Inherited
GTPase activation domain, GAP0.006347Inherited
Calcium ATPase, transmembrane domain M0.006543Inherited
Hedgehog/intein (Hint) domain0.007739Inherited
post-AAA+ oligomerization domain-like0.008422Inherited
BEACH domain0.008422Inherited
Cdc48 domain 2-like0.008422Inherited
beta-sandwich domain of Sec23/240.008422Inherited
Terpenoid cyclases/Protein prenyltransferases0.008422Inherited
Integrin domains0.008422Inherited
ADC-like0.008422Inherited
Calcium ATPase, transduction domain A0.008771Inherited
Zinc beta-ribbon0.009168Inherited
Di-copper centre-containing domain0.009936Inherited
Protein kinase-like (PK-like)0.01053Inherited
Nucleotidylyl transferase0.01144Inherited
Hect, E3 ligase catalytic domain0.02038Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.02038Inherited
Homeodomain-like0.02047Inherited
YWTD domain0.02568Inherited
Chromo domain-like0.02799Inherited
Invertebrate chitin-binding proteins0.02842Inherited
CAD & PB1 domains0.03052Inherited
Caspase-like0.03052Inherited
Cupredoxins0.03052Inherited
S15/NS1 RNA-binding domain0.03052Inherited
Tubby C-terminal domain-like0.03052Inherited
Growth factor receptor domain0.03115Inherited
Cysteine-rich domain0.042Inherited
PLC-like phosphodiesterases0.0463Inherited
Quinoprotein alcohol dehydrogenase-like0.05436Inherited
cAMP-binding domain-like0.07008Inherited
Second domain of FERM0.07358Inherited
Myosin rod fragments0.08679Inherited
EGF/Laminin0.09615Inherited
p53-like transcription factors0.1186Inherited
PDZ domain-like0.1491Inherited
BRCT domain0.1607Inherited
CCCH zinc finger0.1857Inherited
HAD-like0.2415Inherited
Multidrug efflux transporter AcrB transmembrane domain0.2422Inherited
SH2 domain0.249Inherited
PLP-dependent transferases0.3481Inherited
Cysteine proteinases0.3731Inherited
beta-beta-alpha zinc fingers0.382Inherited
Transducin (alpha subunit), insertion domain0.4245Inherited
HSP20-like chaperones0.4764Inherited
Clavaminate synthase-like0.5757Inherited
EF-hand0.5925Inherited
RING/U-box0.6132Inherited
ABC transporter transmembrane region0.628Inherited
POZ domain0.6658Inherited
Immunoglobulin0.6917Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.9028Inherited
Voltage-gated potassium channels0.9409Inherited
Metallo-dependent phosphatases0.9996Inherited
(Phosphotyrosine protein) phosphatases II1Inherited
Saposin1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    48425,50729
  • 48425 - Sec7 domain
  • 50729 - PH domain-like
  • 0Direct
    57863,48403
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0Direct
    49348,55711
  • 49348 - Clathrin adaptor appendage domain
  • 55711 - Subdomain of clathrin and coatomer appendage domain
  • 0Direct
    64356,49447
  • 64356 - SNARE-like
  • 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor
  • 0Direct
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0Direct
    56672,100879
  • 56672 - DNA/RNA polymerases
  • 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.00000000001309Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.00000000005262Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.0000000008063Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.00001119Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.00001119Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.0000243Direct
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.00007626Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.0001106Direct
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.0001527Direct
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.0001527Direct
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0.0001635Direct
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.0001635Direct
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.0002277Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.0007348Direct
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.002299Inherited
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0.00313Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.003976Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.006986Inherited
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0.008422Inherited
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0.008422Inherited
    52540,48019
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 48019 - post-AAA+ oligomerization domain-like
  • 0.008422Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.008422Inherited
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.008422Inherited
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0.009936Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.0121Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.01366Inherited
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.02038Inherited
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0.02568Inherited
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.02568Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.02568Inherited
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0.03052Inherited
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.0463Inherited
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0.1355Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.1756Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.1756Inherited
    52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0.2549Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.334Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.4245Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.5971Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.628Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0Direct
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    48371,48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.00001119Direct
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.0002819Direct
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.002283Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.01576Inherited
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.02038Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.03409Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.03819Inherited
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.09583Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.1236Inherited
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2549Inherited
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0.2549Inherited


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