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Worm Phenotype (WP): cell physiology variant

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Variant [WBPhenotype:0000886] <5>
+ 1:   physiology variant [WBPhenotype:0000519] <6>(490|567) (491|248|69)
0:   cell physiology variant [WBPhenotype:0000536] <27>(143|144) (143|64|18)
- 1:   cell division variant [WBPhenotype:0000746] <19>(49|48) (49|20|5)
- 1:   cell homeostasis metabolism variant [WBPhenotype:0000585] <12>(58|54) (58|23|10)
- 1:   cell secretion variant [WBPhenotype:0000258] <6>(7|8) (8|1|0)
- 1:   neuron physiology variant [WBPhenotype:0000991] <6>(2|4) (2|1|0)
- 1:   cell cycle variant [WBPhenotype:0000740] <5>(4|3) (4|1|0)
- 1:   calcium mediated signaling variant [WBPhenotype:0002170] <4>(0|0) (0|0|0)
- 1:   germ cell physiology variant [WBPhenotype:0000987] <4>(6|5) (6|0|0)
- 1:   nuclear positioning variant [WBPhenotype:0000511] <4>(12|14) (13|5|1)
- 1:   cell death variant [WBPhenotype:0000729] <3>(57|51) (58|17|5)
- 1:   cell membrane physiology variant [WBPhenotype:0001965] <3>(0|0) (0|0|0)
- 1:   membrane trafficking variant [WBPhenotype:0001833] <3>(3|3) (3|1|0)
- 1:   muscle cell physiology variant [WBPhenotype:0000990] <3>(17|16) (17|9|3)
- 1:   oocyte physiology variant [WBPhenotype:0001424] <3>(13|14) (13|6|1)
- 1:   endocytic transport variant [WBPhenotype:0001421] <2>(28|26) (28|11|2)
- 1:   coelomocyte physiology variant [WBPhenotype:0001423] <1>(7|7) (7|2|0)
- 1:   embryonic cell physiology variant [WBPhenotype:0000763] <1>(13|17) (13|6|0)
- 1:   epithelial cell physiology variant [WBPhenotype:0000986] <1>(3|3) (3|2|1)
- 1:   lysosome homeostasis deficient [WBPhenotype:0001784] <1>(0|0) (0|0|0)
- 1:   lysosome organization biogenesis variant [WBPhenotype:0001430] <1>(3|3) (3|2|2)
- 1:   nuclear division variant [WBPhenotype:0000504] <1>(7|8) (7|3|2)
- 1:   plasma membrane composition variant [WBPhenotype:0002177] <1>(4|1) (4|1|1)
- 1:   blast cell physiology variant [WBPhenotype:0000985](0|0) (0|0|0)
- 1:   cell growth variant [WBPhenotype:0010001](0|0) (0|0|0)
- 1:   gland cell physiology variant [WBPhenotype:0000988](0|0) (0|0|0)
- 1:   marginal cell physiology variant [WBPhenotype:0000989](0|0) (0|0|0)
- 1:   peroxisome physiology variant [WBPhenotype:0001264](0|0) (0|0|0)
- 1:   vesicle trafficking variant [WBPhenotype:0001752](0|0) (0|0|0)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Clathrin adaptor appendage domain0Direct
Restriction endonuclease-like0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Subdomain of clathrin and coatomer appendage domain0Direct
Cullin homology domain0Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
Zn-finger domain of Sec23/240Direct
DLC0Direct
LEM domain0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
The spindle assembly checkpoint protein mad20Direct
HSP90 C-terminal domain0Direct
DNA repair protein MutS, domain III0Direct
Sec7 domain0Direct
Histone-fold0Direct
PX domain0Direct
Profilin (actin-binding protein)0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Type II DNA topoisomerase0Direct
VPS9 domain0Direct
ValRS/IleRS/LeuRS editing domain0Direct
RBP11-like subunits of RNA polymerase0Direct
Ribosomal protein L10-like0Direct
14-3-3 protein0Direct
Smc hinge domain0Direct
Helical domain of Sec23/240Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
ARM repeat0Direct
Nicotinic receptor ligand binding domain-like0.0000000000003741Direct
Nucleic acid-binding proteins0.0000000000003854Direct
"Winged helix" DNA-binding domain0.000000000007332Direct
Neurotransmitter-gated ion-channel transmembrane pore0.000000000009688Direct
Skp1 dimerisation domain-like0.00000000003011Direct
PH domain-like0.0000000001308Direct
WD40 repeat-like0.000000000135Direct
Translation proteins0.000002221Direct
GroEL apical domain-like0.000002409Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.000004509Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0.000005057Direct
Translation proteins SH3-like domain0.000005359Direct
SNARE-like0.000007568Direct
GroEL-intermediate domain like0.000009662Direct
t-snare proteins0.000009662Direct
GroEL equatorial domain-like0.000009662Direct
SH3-domain0.00004447Direct
Calponin-homology domain, CH-domain0.0000527Direct
Actin-like ATPase domain0.00007311Direct
ENTH/VHS domain0.00009146Direct
Tubulin C-terminal domain-like0.0002186Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0002542Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0002916Direct
Spectrin repeat0.0002916Direct
Lamin A/C globular tail domain0.0002916Direct
FYVE/PHD zinc finger0.0003413Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0.0005905Direct
Sec1/munc18-like (SM) proteins0.0005905Direct
Tubulin nucleotide-binding domain-like0.0006141Direct
DNA/RNA polymerases0.0007467Direct
Calpain large subunit, middle domain (domain III)0.000884Direct
Prefoldin0.000884Direct
PIN domain-like0.000884Direct
Activating enzymes of the ubiquitin-like proteins0.000884Direct
Class II aaRS ABD-related0.000884Direct
RNA-binding domain, RBD0.001266Inherited
HLH, helix-loop-helix DNA-binding domain0.001428Inherited
Cyclin-like0.002136Inherited
Ribosomal proteins S24e, L23 and L15e0.002267Inherited
F1F0 ATP synthase subunit C0.002267Inherited
Frizzled cysteine-rich domain0.002267Inherited
CAD & PB1 domains0.002267Inherited
Sm-like ribonucleoproteins0.002521Inherited
DBL homology domain (DH-domain)0.002521Inherited
Intermediate filament protein, coiled coil region0.002552Inherited
L30e-like0.002923Inherited
DEATH domain0.002923Inherited
Cullin repeat-like0.002923Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.00331Inherited
Ribosomal protein S5 domain 2-like0.004138Inherited
Nucleotidylyl transferase0.004583Inherited
Calcium ATPase, transmembrane domain M0.005492Inherited
GTPase activation domain, GAP0.006937Inherited
TPR-like0.007213Inherited
Hedgehog/intein (Hint) domain0.007235Inherited
Calcium ATPase, transduction domain A0.007531Inherited
Class II aaRS and biotin synthetases0.007531Inherited
post-AAA+ oligomerization domain-like0.008508Inherited
Cdc48 domain 2-like0.008508Inherited
BEACH domain0.008508Inherited
Integrin domains0.008508Inherited
Terpenoid cyclases/Protein prenyltransferases0.008508Inherited
ADC-like0.008508Inherited
beta-sandwich domain of Sec23/240.008508Inherited
BAR/IMD domain-like0.0095Inherited
Lipovitellin-phosvitin complex, superhelical domain0.009755Inherited
Di-copper centre-containing domain0.009755Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.009755Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.009755Inherited
Translational machinery components0.009755Inherited
Hect, E3 ligase catalytic domain0.0195Inherited
YWTD domain0.02511Inherited
Invertebrate chitin-binding proteins0.0266Inherited
S15/NS1 RNA-binding domain0.03059Inherited
Cupredoxins0.03059Inherited
Tubby C-terminal domain-like0.03059Inherited
Caspase-like0.03059Inherited
Fibronectin type III0.04005Inherited
Quinoprotein alcohol dehydrogenase-like0.04947Inherited
Cysteine-rich domain0.06086Inherited
cAMP-binding domain-like0.06623Inherited
PLC-like phosphodiesterases0.06623Inherited
Second domain of FERM0.06836Inherited
HAD-like0.0773Inherited
Protein kinase-like (PK-like)0.08472Inherited
Myosin rod fragments0.08518Inherited
Homeodomain-like0.09316Inherited
Growth factor receptor domain0.1126Inherited
Chromo domain-like0.1239Inherited
SET domain0.1381Inherited
CCCH zinc finger0.1709Inherited
p53-like transcription factors0.2043Inherited
Multidrug efflux transporter AcrB transmembrane domain0.2228Inherited
SH2 domain0.2358Inherited
PDZ domain-like0.3323Inherited
Cysteine proteinases0.3865Inherited
BRCT domain0.3903Inherited
Transducin (alpha subunit), insertion domain0.4108Inherited
ABC transporter transmembrane region0.4494Inherited
HSP20-like chaperones0.4625Inherited
E set domains0.5193Inherited
Lipocalins0.6096Inherited
EF-hand0.6104Inherited
Immunoglobulin0.6467Inherited
RING/U-box0.746Inherited
POZ domain0.7586Inherited
Voltage-gated potassium channels0.9114Inherited
Metallo-dependent phosphatases0.9571Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.9615Inherited
Saposin1Inherited
(Phosphotyrosine protein) phosphatases II1Inherited
Thioredoxin-like1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Mammalian PLC0Direct
Type II DNA topoisomerase0Direct
DLC0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Trunk domain of Sec23/240Direct
Cullin repeat0Direct
Acyl-carrier protein (ACP)0Direct
Zn-finger domain of Sec23/240Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0Direct
14-3-3 protein0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Protein prenyltransferases0Direct
Hsp90 middle domain0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
LEM domain0Direct
Arginine methyltransferase0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
RNA-polymerase beta0Direct
Integrin domains0Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
DEATH domain, DD0Direct
Clathrin adaptor core protein0Direct
Proteasome subunits0Direct
DNA repair protein MutS, domain III0Direct
SCF ubiquitin ligase complex WHB domain0Direct
Myotubularin-like phosphatases0Direct
5' to 3' exonuclease catalytic domain0Direct
Cullin homology domain0Direct
PX domain0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
Profilin (actin-binding protein)0Direct
Smc hinge domain0Direct
Lesion bypass DNA polymerase (Y-family), catalytic domain0Direct
L30e/L7ae ribosomal proteins0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
HSP90 C-terminal domain0Direct
Helical domain of Sec23/240Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
beta-sandwich domain of Sec23/240Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Cell cycle transcription factor e2f-dp0Direct
Sec7 domain0Direct
Clathrin coat assembly domain0Direct
Nucleosome core histones0.000000000000001886Direct
Skp1 dimerisation domain-like0.00000000004336Direct
Nicotinic receptor ligand binding domain-like0.0000000001034Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0000000004523Direct
FYVE, a phosphatidylinositol-3-phosphate binding domain0.00000002114Direct
Extended AAA-ATPase domain0.0000002099Direct
WD40-repeat0.0000008684Direct
Actin/HSP700.000001207Direct
Pleckstrin-homology domain (PH domain)0.000001372Direct
G proteins0.0000156Direct
Armadillo repeat0.00002453Direct
Group II chaperonin (CCT, TRIC), apical domain0.00003324Direct
t-snare proteins0.00003324Direct
PLC-like (P variant)0.00007614Direct
Pumilio repeat0.00007614Direct
Translational machinery components0.0001119Direct
Group II chaperonin (CCT, TRIC), ATPase domain0.0001119Direct
Phosphotyrosine-binding domain (PTB)0.0001132Direct
Motor proteins0.0003882Direct
Calponin-homology domain, CH-domain0.0004483Direct
Cold shock DNA-binding domain-like0.0006952Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0007023Direct
Tubulin, C-terminal domain0.0009506Direct
SH3-domain0.0009515Direct
Sec1/munc18-like (SM) proteins0.001235Inherited
RecA protein-like (ATPase-domain)0.001235Inherited
Tandem AAA-ATPase domain0.001757Inherited
Elongation factors0.002043Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.002043Inherited
Calpain large subunit, middle domain (domain III)0.002091Inherited
Tubulin, GTPase domain0.002284Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.002493Inherited
Spectrin repeat0.002493Inherited
BTB/POZ domain0.003448Inherited
EF-hand modules in multidomain proteins0.004081Inherited
Frizzled cysteine-rich domain0.004081Inherited
BAR domain0.004081Inherited
Ubiquitin activating enzymes (UBA)0.004081Inherited
F1F0 ATP synthase subunit C0.004081Inherited
Canonical RBD0.005669Inherited
Prefoldin0.00607Inherited
Intermediate filament protein, coiled coil region0.006506Inherited
DBL homology domain (DH-domain)0.008517Inherited
Cyclin0.008517Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.008517Inherited
HLH, helix-loop-helix DNA-binding domain0.009272Inherited
Ephrin ectodomain0.01328Inherited
Anticodon-binding domain of Class II aaRS0.01328Inherited
Cdc48 domain 2-like0.01328Inherited
Anticodon-binding domain0.01328Inherited
Cdc48 N-terminal domain-like0.01328Inherited
Ubiquitin carboxyl-terminal hydrolase UCH-L0.01328Inherited
Caspase catalytic domain0.01328Inherited
BEACH domain0.01328Inherited
DNA polymerase III clamp loader subunits, C-terminal domain0.01328Inherited
Hemocyanin middle domain0.01328Inherited
I set domains0.01456Inherited
Hedgehog C-terminal (Hog) autoprocessing domain0.01587Inherited
LIM domain0.01587Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.01716Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.01716Inherited
Lipovitellin-phosvitin complex, superhelical domain0.01716Inherited
Calcium ATPase, transduction domain A0.02329Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP0.02614Inherited
Histone lysine methyltransferases0.02882Inherited
Nitrogenase iron protein-like0.03143Inherited
Hect, E3 ligase catalytic domain0.03724Inherited
Erythroid transcription factor GATA-10.03724Inherited
Linker histone H1/H50.04303Inherited
DNA polymerase I0.04303Inherited
FAD/NAD-linked reductases, N-terminal and central domains0.04404Inherited
DEP domain0.0469Inherited
BCR-homology GTPase activation domain (BH-domain)0.06364Inherited
cAMP-binding domain0.08571Inherited
PDZ domain0.08608Inherited
Second domain of FERM0.09959Inherited
DnaQ-like 3'-5' exonuclease0.09959Inherited
First domain of FERM0.1017Inherited
Class II glutamine amidotransferases0.1017Inherited
YWTD domain0.1017Inherited
Calpain large subunit, catalytic domain (domain II)0.1253Inherited
Fibronectin type III0.1382Inherited
Fatty acid binding protein-like0.1588Inherited
ABC transporter ATPase domain-like0.1658Inherited
Third domain of FERM0.202Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.2345Inherited
Multidrug efflux transporter AcrB transmembrane domain0.2782Inherited
Homeodomain0.2955Inherited
RING finger domain, C3HC40.306Inherited
CCCH zinc finger0.3308Inherited
ABC transporter transmembrane region0.5156Inherited
SH2 domain0.5435Inherited
Protein kinases, catalytic subunit0.548Inherited
Transducin (alpha subunit), insertion domain0.5922Inherited
Glutathione peroxidase-like0.8598Inherited
Voltage-gated potassium channels1Inherited
Glutathione S-transferase (GST), N-terminal domain1Inherited


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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Profilin (actin-binding protein)0Direct
DNA repair protein MutS, domain III0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
The spindle assembly checkpoint protein mad20Direct
DLC0Direct
Ribosomal protein L10-like0Direct
ARM repeat0Direct
Sec7 domain0Direct
Clathrin adaptor appendage domain0Direct
Histone-fold0Direct
RBP11-like subunits of RNA polymerase0Direct
Helical domain of Sec23/240Direct
Restriction endonuclease-like0Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
Cullin homology domain0Direct
Zn-finger domain of Sec23/240Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
PX domain0Direct
HSP90 C-terminal domain0Direct
Type II DNA topoisomerase0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Smc hinge domain0Direct
14-3-3 protein0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
VPS9 domain0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
LEM domain0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Nicotinic receptor ligand binding domain-like0.0000000000002924Direct
Nucleic acid-binding proteins0.0000000000003013Direct
"Winged helix" DNA-binding domain0.000000000005753Direct
Neurotransmitter-gated ion-channel transmembrane pore0.000000000007605Direct
Skp1 dimerisation domain-like0.00000000002366Direct
PH domain-like0.000000000103Direct
WD40 repeat-like0.0000000001063Direct
Translation proteins0.000001791Direct
GroEL apical domain-like0.000001942Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.000003639Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0.000004086Direct
Translation proteins SH3-like domain0.00000433Direct
SNARE-like0.00000612Direct
GroEL equatorial domain-like0.00000781Direct
t-snare proteins0.00000781Direct
GroEL-intermediate domain like0.00000781Direct
SH3-domain0.00003614Direct
Calponin-homology domain, CH-domain0.00004288Direct
Actin-like ATPase domain0.00005948Direct
ENTH/VHS domain0.00007453Direct
Tubulin C-terminal domain-like0.0001787Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0002081Direct
Lamin A/C globular tail domain0.0002388Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0002388Direct
Spectrin repeat0.0002388Direct
FYVE/PHD zinc finger0.0002799Direct
Sec1/munc18-like (SM) proteins0.0004865Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0.0004865Direct
Tubulin nucleotide-binding domain-like0.0005062Direct
DNA/RNA polymerases0.0006166Direct
PIN domain-like0.0007309Direct
Class II aaRS ABD-related0.0007309Direct
Prefoldin0.0007309Direct
Calpain large subunit, middle domain (domain III)0.0007309Direct
Activating enzymes of the ubiquitin-like proteins0.0007309Direct
RNA-binding domain, RBD0.00105Inherited
HLH, helix-loop-helix DNA-binding domain0.001187Inherited
Cyclin-like0.001786Inherited
Ribosomal proteins S24e, L23 and L15e0.001898Inherited
F1F0 ATP synthase subunit C0.001898Inherited
CAD & PB1 domains0.001898Inherited
Frizzled cysteine-rich domain0.001898Inherited
Sm-like ribonucleoproteins0.002114Inherited
DBL homology domain (DH-domain)0.002114Inherited
Intermediate filament protein, coiled coil region0.00214Inherited
DEATH domain0.002455Inherited
Cullin repeat-like0.002455Inherited
L30e-like0.002455Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.002784Inherited
Ribosomal protein S5 domain 2-like0.003489Inherited
Nucleotidylyl transferase0.003873Inherited
Calcium ATPase, transmembrane domain M0.004651Inherited
GTPase activation domain, GAP0.005891Inherited
TPR-like0.006128Inherited
Hedgehog/intein (Hint) domain0.006147Inherited
Calcium ATPase, transduction domain A0.006405Inherited
Class II aaRS and biotin synthetases0.006405Inherited
Integrin domains0.007254Inherited
Terpenoid cyclases/Protein prenyltransferases0.007254Inherited
beta-sandwich domain of Sec23/240.007254Inherited
BEACH domain0.007254Inherited
Cdc48 domain 2-like0.007254Inherited
post-AAA+ oligomerization domain-like0.007254Inherited
ADC-like0.007254Inherited
BAR/IMD domain-like0.00811Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.008332Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.008332Inherited
Translational machinery components0.008332Inherited
Lipovitellin-phosvitin complex, superhelical domain0.008332Inherited
Di-copper centre-containing domain0.008332Inherited
Hect, E3 ligase catalytic domain0.01688Inherited
YWTD domain0.02186Inherited
Invertebrate chitin-binding proteins0.0232Inherited
Caspase-like0.02672Inherited
S15/NS1 RNA-binding domain0.02672Inherited
Cupredoxins0.02672Inherited
Tubby C-terminal domain-like0.02672Inherited
Fibronectin type III0.03516Inherited
Quinoprotein alcohol dehydrogenase-like0.04364Inherited
Cysteine-rich domain0.05395Inherited
PLC-like phosphodiesterases0.05884Inherited
cAMP-binding domain-like0.05884Inherited
Second domain of FERM0.06076Inherited
HAD-like0.06891Inherited
Protein kinase-like (PK-like)0.07575Inherited
Myosin rod fragments0.07618Inherited
Homeodomain-like0.08354Inherited
Growth factor receptor domain0.1015Inherited
Chromo domain-like0.1121Inherited
SET domain0.1255Inherited
CCCH zinc finger0.1562Inherited
p53-like transcription factors0.1878Inherited
Multidrug efflux transporter AcrB transmembrane domain0.2055Inherited
SH2 domain0.2181Inherited
PDZ domain-like0.3116Inherited
Cysteine proteinases0.3648Inherited
BRCT domain0.3685Inherited
Transducin (alpha subunit), insertion domain0.3886Inherited
ABC transporter transmembrane region0.4266Inherited
HSP20-like chaperones0.4395Inherited
E set domains0.4963Inherited
Lipocalins0.5871Inherited
EF-hand0.588Inherited
Immunoglobulin0.6248Inherited
RING/U-box0.7269Inherited
POZ domain0.7397Inherited
Voltage-gated potassium channels0.8983Inherited
Metallo-dependent phosphatases0.946Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.9506Inherited
Saposin1Inherited
(Phosphotyrosine protein) phosphatases II1Inherited
Thioredoxin-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    64356,49447
  • 64356 - SNARE-like
  • 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    48425,50729
  • 48425 - Sec7 domain
  • 50729 - PH domain-like
  • 0Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    49348,55711
  • 49348 - Clathrin adaptor appendage domain
  • 55711 - Subdomain of clathrin and coatomer appendage domain
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    57863,48403
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    56672,100879
  • 56672 - DNA/RNA polymerases
  • 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain
  • 0Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.000000000006072Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.000000000007605Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.0000000211Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.00000781Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.00000781Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.00001275Direct
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.000124Direct
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0.000124Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.0001787Direct
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.000198Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0002081Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.0005062Direct
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.0008324Direct
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.001898Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.002042Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.002784Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.003713Inherited
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0.007254Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.007254Inherited
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0.007254Inherited
    52540,48019
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 48019 - post-AAA+ oligomerization domain-like
  • 0.007254Inherited
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.007254Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.007377Inherited
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0.008332Inherited
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0.008332Inherited
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.008332Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.009471Inherited
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.02186Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.02186Inherited
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0.02186Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0262Inherited
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0.02672Inherited
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.03834Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.05884Inherited
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0.06069Inherited
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0.1186Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.1529Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.1529Inherited
    52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0.2355Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.2868Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.3886Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.4266Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 1Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.00000781Direct
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.0002081Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0002081Direct
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.001575Inherited
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.008332Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.01274Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.03202Inherited
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.08281Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.1015Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.2032Inherited
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2355Inherited
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0.2355Inherited


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