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Worm Phenotype (WP): cell physiology variant

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Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Variant [WBPhenotype:0000886] <2>
+ 1:   physiology variant [WBPhenotype:0000519] <14>(510|587) (510|248|68)
0:   cell physiology variant [WBPhenotype:0000536] <36>(149|149) (150|64|19)
- 1:   cell division variant [WBPhenotype:0000746] <19>(51|54) (52|20|4)
- 1:   cell homeostasis metabolism variant [WBPhenotype:0000585] <12>(60|54) (60|23|12)
- 1:   neuron physiology variant [WBPhenotype:0000991] <10>(3|4) (3|1|0)
- 1:   muscle cell physiology variant [WBPhenotype:0000990] <8>(21|22) (22|13|4)
- 1:   cell cycle variant [WBPhenotype:0000740] <6>(35|35) (35|17|4)
- 1:   cell secretion variant [WBPhenotype:0000258] <6>(7|8) (7|1|0)
- 1:   germ cell physiology variant [WBPhenotype:0000987] <6>(28|19) (29|8|1)
- 1:   calcium mediated signaling variant [WBPhenotype:0002170] <5>(0|0) (0|0|0)
- 1:   nuclear positioning variant [WBPhenotype:0000511] <5>(12|14) (13|5|1)
- 1:   epithelial cell physiology variant [WBPhenotype:0000986] <4>(3|3) (3|2|1)
- 1:   cell death variant [WBPhenotype:0000729] <3>(58|51) (58|15|5)
- 1:   cell membrane physiology variant [WBPhenotype:0001965] <3>(0|0) (0|0|0)
- 1:   membrane trafficking variant [WBPhenotype:0001833] <3>(4|3) (4|1|0)
- 1:   coelomocyte physiology variant [WBPhenotype:0001423] <2>(7|7) (7|2|0)
- 1:   vesicle trafficking variant [WBPhenotype:0001752] <2>(31|26) (32|10|2)
- 1:   P lineages variant [WBPhenotype:0000099] <1>(2|2) (2|0|0)
- 1:   accessory cell physiology variant [WBPhenotype:0000974] <1>(0|0) (0|0|0)
- 1:   embryonic cell physiology variant [WBPhenotype:0000763] <1>(12|17) (13|6|0)
- 1:   lysosome homeostasis deficient [WBPhenotype:0001784] <1>(0|0) (0|0|0)
- 1:   lysosome organization biogenesis variant [WBPhenotype:0001430] <1>(3|3) (3|2|2)
- 1:   nuclear division variant [WBPhenotype:0000504] <1>(7|8) (7|4|2)
- 1:   plasma membrane composition variant [WBPhenotype:0002177] <1>(4|1) (4|1|1)
- 1:   AB lineage variant [WBPhenotype:0000097](0|0) (0|0|0)
- 1:   B lineage variant [WBPhenotype:0000830](0|0) (0|0|0)
- 1:   C lineage variant [WBPhenotype:0000832](0|0) (0|0|0)
- 1:   D lineage variant [WBPhenotype:0000935](0|0) (0|0|0)
- 1:   E lineage variant [WBPhenotype:0000834](0|0) (0|0|0)
- 1:   M lineage variant [WBPhenotype:0000095](1|1) (1|0|0)
- 1:   MS lineage variant [WBPhenotype:0000933](0|0) (0|0|0)
- 1:   Q lineage variant [WBPhenotype:0000829](0|0) (0|0|0)
- 1:   blast cell physiology variant [WBPhenotype:0000985](0|0) (0|0|0)
- 1:   cell growth variant [WBPhenotype:0010001](0|0) (0|0|0)
- 1:   centrosome dynamics variant [WBPhenotype:0002074](0|0) (0|0|0)
- 1:   gland cell physiology variant [WBPhenotype:0000988](0|0) (0|0|0)
- 1:   intestinal cell proliferation variant [WBPhenotype:0000092](0|0) (0|0|0)
- 1:   peroxisome physiology variant [WBPhenotype:0001264](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Ribosomal protein L10-like0Direct
Helical domain of Sec23/240Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Smc hinge domain0Direct
PX domain0Direct
Lipovitellin-phosvitin complex, superhelical domain0Direct
RBP11-like subunits of RNA polymerase0Direct
DLC0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
LEM domain0Direct
Sec1/munc18-like (SM) proteins0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
DNA repair protein MutS, domain III0Direct
Heme-dependent catalase-like0Direct
14-3-3 protein0Direct
VPS9 domain0Direct
Profilin (actin-binding protein)0Direct
Zn-finger domain of Sec23/240Direct
ValRS/IleRS/LeuRS editing domain0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Cullin homology domain0Direct
Clathrin adaptor appendage domain0Direct
ARM repeat0Direct
HSP90 C-terminal domain0Direct
Restriction endonuclease-like0Direct
Sec7 domain0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
The spindle assembly checkpoint protein mad20Direct
HRDC-like0Direct
Ribosomal protein S100Direct
Histone-fold4.49e-16Direct
"Winged helix" DNA-binding domain0.0000000000002196Direct
Nucleic acid-binding proteins0.0000000000002374Direct
Nicotinic receptor ligand binding domain-like0.000000000003434Direct
Skp1 dimerisation domain-like0.00000000006739Direct
Neurotransmitter-gated ion-channel transmembrane pore0.00000000006877Direct
PH domain-like0.0000000001094Direct
WD40 repeat-like0.000000001417Direct
FYVE/PHD zinc finger0.000000432Direct
RNA-binding domain, RBD0.000001921Direct
GroEL apical domain-like0.000003609Direct
Translation proteins SH3-like domain0.00000823Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.000008627Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0.00001177Direct
SNARE-like0.00001194Direct
Arginase/deacetylase0.00001384Direct
t-snare proteins0.00001384Direct
GroEL-intermediate domain like0.00001384Direct
GroEL equatorial domain-like0.00001384Direct
SH3-domain0.00003307Direct
DNA/RNA polymerases0.00003942Direct
Class II aaRS ABD-related0.0000529Direct
HLH, helix-loop-helix DNA-binding domain0.00006097Direct
Calponin-homology domain, CH-domain0.00009418Direct
ENTH/VHS domain0.000136Direct
Translation proteins0.0001506Direct
Tubulin C-terminal domain-like0.00033Direct
L30e-like0.0003441Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0004054Direct
Spectrin repeat0.0004054Direct
Lamin A/C globular tail domain0.0004054Direct
Actin-like ATPase domain0.0004934Direct
TPR-like0.0006952Direct
Translational machinery components0.0007457Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0.0007457Direct
Tubulin nucleotide-binding domain-like0.0008904Direct
Cyclin-like0.0009252Direct
PIN domain-like0.001147Inherited
Prefoldin0.001147Inherited
Calpain large subunit, middle domain (domain III)0.001147Inherited
Activating enzymes of the ubiquitin-like proteins0.001147Inherited
Class II aaRS and biotin synthetases0.002728Inherited
F1F0 ATP synthase subunit C0.002737Inherited
Ribosomal proteins S24e, L23 and L15e0.002737Inherited
Frizzled cysteine-rich domain0.002737Inherited
Tropomyosin0.003351Inherited
Intermediate filament protein, coiled coil region0.003351Inherited
DBL homology domain (DH-domain)0.003547Inherited
Sm-like ribonucleoproteins0.003547Inherited
Zn-binding ribosomal proteins0.003715Inherited
DEATH domain0.003736Inherited
Cullin repeat-like0.003736Inherited
DHS-like NAD/FAD-binding domain0.003736Inherited
Ribosomal protein S5 domain 2-like0.004588Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.004719Inherited
SET domain0.006094Inherited
Ubiquitin-like0.006513Inherited
BAR/IMD domain-like0.006707Inherited
GTPase activation domain, GAP0.00749Inherited
Calcium ATPase, transmembrane domain M0.007711Inherited
Hedgehog/intein (Hint) domain0.009057Inherited
ADC-like0.009835Inherited
post-AAA+ oligomerization domain-like0.009835Inherited
Terpenoid cyclases/Protein prenyltransferases0.009835Inherited
Cdc48 domain 2-like0.009835Inherited
BEACH domain0.009835Inherited
beta-sandwich domain of Sec23/240.009835Inherited
Integrin domains0.009835Inherited
Calcium ATPase, transduction domain A0.01026Inherited
Di-copper centre-containing domain0.01158Inherited
Nucleotidylyl transferase0.01333Inherited
Protein kinase-like (PK-like)0.01517Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.02344Inherited
Hect, E3 ligase catalytic domain0.02344Inherited
Homeodomain-like0.02377Inherited
YWTD domain0.02937Inherited
Chromo domain-like0.03202Inherited
Invertebrate chitin-binding proteins0.03246Inherited
Tubby C-terminal domain-like0.03479Inherited
S15/NS1 RNA-binding domain0.03479Inherited
Cupredoxins0.03479Inherited
CAD & PB1 domains0.03479Inherited
Caspase-like0.03479Inherited
Growth factor receptor domain0.0356Inherited
Cysteine-rich domain0.04774Inherited
PLC-like phosphodiesterases0.05237Inherited
Quinoprotein alcohol dehydrogenase-like0.06132Inherited
cAMP-binding domain-like0.07844Inherited
Second domain of FERM0.08225Inherited
Myosin rod fragments0.09645Inherited
EGF/Laminin0.1071Inherited
p53-like transcription factors0.131Inherited
PDZ domain-like0.1639Inherited
BRCT domain0.1757Inherited
CCCH zinc finger0.2023Inherited
HAD-like0.2605Inherited
Multidrug efflux transporter AcrB transmembrane domain0.261Inherited
SH2 domain0.2685Inherited
PLP-dependent transferases0.3697Inherited
Cysteine proteinases0.3955Inherited
beta-beta-alpha zinc fingers0.4045Inherited
Transducin (alpha subunit), insertion domain0.4464Inherited
HSP20-like chaperones0.4991Inherited
Clavaminate synthase-like0.5984Inherited
EF-hand0.6167Inherited
RING/U-box0.6204Inherited
ABC transporter transmembrane region0.6508Inherited
POZ domain0.6894Inherited
Immunoglobulin0.7138Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.9187Inherited
Voltage-gated potassium channels0.9552Inherited
(Phosphotyrosine protein) phosphatases II1Inherited
Saposin1Inherited
Metallo-dependent phosphatases1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
DNA replication initiator (cdc21/cdc54) N-terminal domain0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
beta-sandwich domain of Sec23/240Direct
Sir2 family of transcriptional regulators0Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
Laminin-type module0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
Brix domain0Direct
DNA repair protein MutS, domain III0Direct
Heme-dependent catalases0Direct
Lipovitellin-phosvitin complex, superhelical domain0Direct
PX domain0Direct
Cullin repeat0Direct
Ribosomal protein S100Direct
DLC0Direct
Hsp90 middle domain0Direct
Lesion bypass DNA polymerase (Y-family), catalytic domain0Direct
Helical domain of Sec23/240Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
L30e/L7ae ribosomal proteins0Direct
XPF/Rad1/Mus81 nuclease0Direct
Smc hinge domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Acyl-carrier protein (ACP)0Direct
Myotubularin-like phosphatases0Direct
Sec1/munc18-like (SM) proteins0Direct
Zn-finger domain of Sec23/240Direct
SCF ubiquitin ligase complex WHB domain0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0Direct
Clathrin adaptor core protein0Direct
RNA-polymerase beta0Direct
Protein prenyltransferases0Direct
14-3-3 protein0Direct
Proteasome subunits0Direct
Sec7 domain0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Histone deacetylase, HDAC0Direct
Clathrin coat assembly domain0Direct
Mammalian PLC0Direct
LEM domain0Direct
Cullin homology domain0Direct
DEATH domain, DD0Direct
Trunk domain of Sec23/240Direct
Cell cycle transcription factor e2f-dp0Direct
HSP90 C-terminal domain0Direct
MIF4G domain-like0Direct
Integrin domains0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Profilin (actin-binding protein)0Direct
5' to 3' exonuclease catalytic domain0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Arginine methyltransferase0Direct
Nucleosome core histones0.00000000000001062Direct
Skp1 dimerisation domain-like0.00000000008564Direct
Nicotinic receptor ligand binding domain-like0.0000000005729Direct
Neurotransmitter-gated ion-channel transmembrane pore0.00000000174Direct
FYVE, a phosphatidylinositol-3-phosphate binding domain0.00000003512Direct
Extended AAA-ATPase domain0.000001082Direct
Actin/HSP700.000002135Direct
Pleckstrin-homology domain (PH domain)0.000002744Direct
WD40-repeat0.000003545Direct
Canonical RBD0.000007147Direct
Armadillo repeat0.00003484Direct
t-snare proteins0.00004463Direct
Group II chaperonin (CCT, TRIC), apical domain0.00004463Direct
PLC-like (P variant)0.0001044Direct
Group II chaperonin (CCT, TRIC), ATPase domain0.0001449Direct
Translational machinery components0.0001449Direct
Phosphotyrosine-binding domain (PTB)0.0001579Direct
G proteins0.0002057Direct
Pumilio repeat0.0003078Direct
Motor proteins0.0006504Direct
HLH, helix-loop-helix DNA-binding domain0.0006504Direct
Calponin-homology domain, CH-domain0.0007016Direct
SH3-domain0.0007095Direct
Cold shock DNA-binding domain-like0.001024Inherited
Tandem AAA-ATPase domain0.001032Inherited
Histone lysine methyltransferases0.001316Inherited
Tubulin, C-terminal domain0.001316Inherited
RecA protein-like (ATPase-domain)0.00149Inherited
Calpain large subunit, middle domain (domain III)0.002569Inherited
Cyclin0.002782Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.002782Inherited
Tubulin, GTPase domain0.003044Inherited
Spectrin repeat0.00312Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.00312Inherited
Tetratricopeptide repeat (TPR)0.004492Inherited
BAR domain0.004736Inherited
Ubiquitin activating enzymes (UBA)0.004736Inherited
Frizzled cysteine-rich domain0.004736Inherited
F1F0 ATP synthase subunit C0.004736Inherited
EF-hand modules in multidomain proteins0.004736Inherited
Prefoldin0.007176Inherited
DNA polymerase I0.007176Inherited
BTB/POZ domain0.00773Inherited
Intermediate filament protein, coiled coil region0.008016Inherited
Tropomyosin0.008016Inherited
DBL homology domain (DH-domain)0.01104Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.01104Inherited
Ephrin ectodomain0.01484Inherited
DNA polymerase III clamp loader subunits, C-terminal domain0.01484Inherited
Cdc48 domain 2-like0.01484Inherited
Anticodon-binding domain0.01484Inherited
Hemocyanin middle domain0.01484Inherited
BEACH domain0.01484Inherited
Cdc48 N-terminal domain-like0.01484Inherited
Anticodon-binding domain of Class II aaRS0.01484Inherited
Caspase catalytic domain0.01484Inherited
I set domains0.01858Inherited
Single strand DNA-binding domain, SSB0.01888Inherited
LIM domain0.01888Inherited
Hedgehog C-terminal (Hog) autoprocessing domain0.01888Inherited
PDZ domain0.02375Inherited
Calcium ATPase, transduction domain A0.02942Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP0.03144Inherited
Elongation factors0.03562Inherited
Nitrogenase iron protein-like0.03695Inherited
Homeodomain0.04218Inherited
Hect, E3 ligase catalytic domain0.04291Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.04291Inherited
DnaQ-like 3'-5' exonuclease0.04312Inherited
PHD domain0.04404Inherited
Linker histone H1/H50.04856Inherited
DEP domain0.05177Inherited
BCR-homology GTPase activation domain (BH-domain)0.06281Inherited
cAMP-binding domain0.09804Inherited
First domain of FERM0.1108Inherited
YWTD domain0.1108Inherited
Class II glutamine amidotransferases0.1108Inherited
Second domain of FERM0.1151Inherited
Calpain large subunit, catalytic domain (domain II)0.1416Inherited
Myosin rod fragments0.1501Inherited
Growth factor receptor domain0.1933Inherited
Protein kinases, catalytic subunit0.2151Inherited
Third domain of FERM0.2192Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.2636Inherited
ABC transporter ATPase domain-like0.2811Inherited
Multidrug efflux transporter AcrB transmembrane domain0.3157Inherited
RING finger domain, C3HC40.3436Inherited
CCCH zinc finger0.3689Inherited
SH2 domain0.568Inherited
Transducin (alpha subunit), insertion domain0.6225Inherited
ABC transporter transmembrane region0.7096Inherited
Voltage-gated potassium channels1Inherited
Protein serine/threonine phosphatase1Inherited


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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Ribosomal protein L10-like0Direct
Ribosomal protein S100Direct
ValRS/IleRS/LeuRS editing domain0Direct
Clathrin adaptor appendage domain0Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
Cullin homology domain0Direct
Heme-dependent catalase-like0Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
14-3-3 protein0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
LEM domain0Direct
Profilin (actin-binding protein)0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
DNA repair protein MutS, domain III0Direct
HSP90 C-terminal domain0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
RBP11-like subunits of RNA polymerase0Direct
VPS9 domain0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
Helical domain of Sec23/240Direct
Lipovitellin-phosvitin complex, superhelical domain0Direct
Sec1/munc18-like (SM) proteins0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
The spindle assembly checkpoint protein mad20Direct
Restriction endonuclease-like0Direct
ARM repeat0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
DLC0Direct
HRDC-like0Direct
PX domain0Direct
Zn-finger domain of Sec23/240Direct
Smc hinge domain0Direct
Sec7 domain0Direct
Histone-fold3.517e-16Direct
"Winged helix" DNA-binding domain0.0000000000001726Direct
Nucleic acid-binding proteins0.0000000000001866Direct
Nicotinic receptor ligand binding domain-like0.000000000002709Direct
Skp1 dimerisation domain-like0.00000000005329Direct
Neurotransmitter-gated ion-channel transmembrane pore0.00000000005439Direct
PH domain-like0.00000000008657Direct
WD40 repeat-like0.000000001126Direct
FYVE/PHD zinc finger0.0000003479Direct
RNA-binding domain, RBD0.000001556Direct
GroEL apical domain-like0.000002931Direct
Translation proteins SH3-like domain0.000006693Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.000007016Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0.000009581Direct
SNARE-like0.000009719Direct
GroEL equatorial domain-like0.00001127Direct
t-snare proteins0.00001127Direct
GroEL-intermediate domain like0.00001127Direct
Arginase/deacetylase0.00001127Direct
SH3-domain0.000027Direct
DNA/RNA polymerases0.00003221Direct
Class II aaRS ABD-related0.00004328Direct
HLH, helix-loop-helix DNA-binding domain0.00004989Direct
Calponin-homology domain, CH-domain0.00007717Direct
ENTH/VHS domain0.0001115Direct
Translation proteins0.0001236Direct
Tubulin C-terminal domain-like0.000272Direct
L30e-like0.0002837Direct
Lamin A/C globular tail domain0.0003347Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0003347Direct
Spectrin repeat0.0003347Direct
Actin-like ATPase domain0.0004084Direct
TPR-like0.0005767Direct
Translational machinery components0.0006195Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0.0006195Direct
Tubulin nucleotide-binding domain-like0.0007405Direct
Cyclin-like0.0007698Direct
PIN domain-like0.0009559Direct
Prefoldin0.0009559Direct
Activating enzymes of the ubiquitin-like proteins0.0009559Direct
Calpain large subunit, middle domain (domain III)0.0009559Direct
Class II aaRS and biotin synthetases0.0023Inherited
F1F0 ATP synthase subunit C0.002308Inherited
Ribosomal proteins S24e, L23 and L15e0.002308Inherited
Frizzled cysteine-rich domain0.002308Inherited
Intermediate filament protein, coiled coil region0.002833Inherited
Tropomyosin0.002833Inherited
DBL homology domain (DH-domain)0.003001Inherited
Sm-like ribonucleoproteins0.003001Inherited
Zn-binding ribosomal proteins0.003146Inherited
DHS-like NAD/FAD-binding domain0.003164Inherited
Cullin repeat-like0.003164Inherited
DEATH domain0.003164Inherited
Ribosomal protein S5 domain 2-like0.003894Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.004006Inherited
SET domain0.00519Inherited
Ubiquitin-like0.005554Inherited
BAR/IMD domain-like0.00572Inherited
GTPase activation domain, GAP0.006399Inherited
Calcium ATPase, transmembrane domain M0.006591Inherited
Hedgehog/intein (Hint) domain0.007774Inherited
Cdc48 domain 2-like0.008452Inherited
Integrin domains0.008452Inherited
post-AAA+ oligomerization domain-like0.008452Inherited
BEACH domain0.008452Inherited
beta-sandwich domain of Sec23/240.008452Inherited
Terpenoid cyclases/Protein prenyltransferases0.008452Inherited
ADC-like0.008452Inherited
Calcium ATPase, transduction domain A0.00883Inherited
Zinc beta-ribbon0.009208Inherited
Di-copper centre-containing domain0.009976Inherited
Nucleotidylyl transferase0.01153Inherited
Protein kinase-like (PK-like)0.01314Inherited
Hect, E3 ligase catalytic domain0.02047Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.02047Inherited
Homeodomain-like0.02076Inherited
YWTD domain0.02577Inherited
Chromo domain-like0.02815Inherited
Invertebrate chitin-binding proteins0.02854Inherited
Tubby C-terminal domain-like0.03061Inherited
CAD & PB1 domains0.03061Inherited
Cupredoxins0.03061Inherited
Caspase-like0.03061Inherited
S15/NS1 RNA-binding domain0.03061Inherited
Growth factor receptor domain0.03133Inherited
Cysteine-rich domain0.04225Inherited
PLC-like phosphodiesterases0.04647Inherited
Quinoprotein alcohol dehydrogenase-like0.05461Inherited
cAMP-binding domain-like0.07033Inherited
Second domain of FERM0.07385Inherited
Myosin rod fragments0.08701Inherited
EGF/Laminin0.09687Inherited
p53-like transcription factors0.1191Inherited
PDZ domain-like0.15Inherited
BRCT domain0.1613Inherited
CCCH zinc finger0.1864Inherited
HAD-like0.2425Inherited
Multidrug efflux transporter AcrB transmembrane domain0.2431Inherited
SH2 domain0.2504Inherited
PLP-dependent transferases0.3493Inherited
Cysteine proteinases0.3749Inherited
beta-beta-alpha zinc fingers0.3838Inherited
Transducin (alpha subunit), insertion domain0.4255Inherited
HSP20-like chaperones0.4774Inherited
Clavaminate synthase-like0.5766Inherited
EF-hand0.5946Inherited
RING/U-box0.5983Inherited
ABC transporter transmembrane region0.6292Inherited
POZ domain0.6684Inherited
Immunoglobulin0.6932Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.9039Inherited
Voltage-gated potassium channels0.9418Inherited
Metallo-dependent phosphatases0.9995Inherited
(Phosphotyrosine protein) phosphatases II1Inherited
Saposin1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    48425,50729
  • 48425 - Sec7 domain
  • 50729 - PH domain-like
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0Direct
    56672,100879
  • 56672 - DNA/RNA polymerases
  • 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    64356,49447
  • 64356 - SNARE-like
  • 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor
  • 0Direct
    57863,48403
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0Direct
    49348,55711
  • 49348 - Clathrin adaptor appendage domain
  • 55711 - Subdomain of clathrin and coatomer appendage domain
  • 0Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.0000000000133Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.00000000005439Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.0000000008171Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.00001127Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.00001127Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.00002462Direct
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.00007717Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.0001115Direct
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.0001543Direct
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.0001645Direct
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0.0001645Direct
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.0001901Direct
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.0002298Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.0007405Direct
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.002308Inherited
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0.003146Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.003433Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.004006Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.007029Inherited
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0.008452Inherited
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.008452Inherited
    52540,48019
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 48019 - post-AAA+ oligomerization domain-like
  • 0.008452Inherited
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0.008452Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.008452Inherited
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0.009976Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.01217Inherited
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.02047Inherited
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.02577Inherited
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0.02577Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.02577Inherited
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0.03061Inherited
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.04647Inherited
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0.1358Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.1761Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.1761Inherited
    52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0.2554Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.3352Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.4255Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.5984Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.6292Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48371,48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0Direct
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.00001127Direct
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.0002837Direct
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.0023Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.01584Inherited
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.02047Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.03425Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.03833Inherited
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.09611Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.1241Inherited
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0.2554Inherited
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2554Inherited


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