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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

• Disease Ontology (DO) Ontology (DO)
  DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
  
• Human Phenotype (HP) Ontology (HP)
  HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
  
• Mouse Phenotype (MP) Ontology (MP)
  MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
  
• Worm Phenotype (WP) Ontology (WP)
  WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
  
• Yeast Phenotype (YP) Ontology (YP)
  Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
  
• Fly Phenotype (FP) Ontology (FP)
  FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
  
• Fly Anatomy (FA) Ontology (FA)
  FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
  
• Zebrafish Anatomy (ZA) Ontology (ZA)
  ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
  
• Xenopus Anatomy (XA) Ontology (XA)
  XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
  
• Arabidopsis Plant Ontology (AP) Ontology (AP)
  As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
  
• Enzyme Commission (EC) Ontology (EC)
  Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
  
• DrugBank ATC (DB) Ontology (DB)
  In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
  
• UniProtKB KeyWords (KW) Ontology (KW)
  Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
  
• UniProtKB UniPathway (UP) Ontology (UP)
  UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
  

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
  

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
  

Superfamily domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Di-copper centre-containing domain	0	DIRECT
Serine protease inhibitors	0	DIRECT
Integrin alpha N-terminal domain	0	DIRECT
Cytochrome c	0	DIRECT
Six-hairpin glycosidases	0	DIRECT
Class II aaRS ABD-related	0	DIRECT
FAD-linked oxidases, C-terminal domain	0	DIRECT
BEACH domain	0	DIRECT
CBS-domain pair	0	DIRECT
Ferritin-like	0	DIRECT
ACP-like	0	DIRECT
EF-G C-terminal domain-like	0	DIRECT
BolA-like	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
Mob1/phocein	0	DIRECT
Transcription factor IIA (TFIIA), beta-barrel domain	0	DIRECT
Hect, E3 ligase catalytic domain	0	DIRECT
HIT-like	0	DIRECT
VPS9 domain	0	DIRECT
FAD/NAD(P)-binding domain	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
HIT/MYND zinc finger-like	0	DIRECT
KA1-like	0	DIRECT
Kringle-like	0	DIRECT
Formin homology 2 domain (FH2 domain)	0	DIRECT
Ferredoxin reductase-like, C-terminal NADP-linked domain	0	DIRECT
MFPT repeat-like	0	DIRECT
PEP carboxykinase-like	0	DIRECT
DNase I-like	0	DIRECT
CalX-like	0	DIRECT
ADP-ribosylation	0	DIRECT
Families 57/38 glycoside transferase middle domain	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Intermediate filament protein, coiled coil region	0	DIRECT
Cation efflux protein transmembrane domain-like	0	DIRECT
GroEL apical domain-like	0	DIRECT
Glycoside hydrolase/deacetylase	0	DIRECT
t-snare proteins	0	DIRECT
E2F-DP heterodimerization region	0	DIRECT
Lipovitellin-phosvitin complex, superhelical domain	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Ricin B-like lectins	0	DIRECT
Translational machinery components	0	DIRECT
alpha-catenin/vinculin-like	0	DIRECT
TAZ domain	0	DIRECT
TGS-like	0	DIRECT
Actin-crosslinking proteins	0	DIRECT
Alpha-L RNA-binding motif	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Phospholipase D/nuclease	0	DIRECT
Kix domain of CBP (creb binding protein)	0	DIRECT
Tubulin nucleotide-binding domain-like	0	DIRECT
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0	DIRECT
DHS-like NAD/FAD-binding domain	0	DIRECT
Caspase-like	0	DIRECT
Periplasmic binding protein-like I	0	DIRECT
PH domain-like	0	DIRECT
SMR domain-like	0	DIRECT
PDZ domain-like	0	DIRECT
Nucleoporin domain	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
UBC-like	0	DIRECT
Pectin lyase-like	0	DIRECT
PEBP-like	0	DIRECT
L30e-like	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
GHMP Kinase, C-terminal domain	0	DIRECT
Purine and uridine phosphorylases	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
Myosin rod fragments	0	DIRECT
ARID-like	0	DIRECT
CCCH zinc finger	0	DIRECT
Alkaline phosphatase-like	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Subdomain of clathrin and coatomer appendage domain	0	DIRECT
Ypt/Rab-GAP domain of gyp1p	0	DIRECT
Tim10-like	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
Proton glutamate symport protein	0	DIRECT
ArfGap/RecO-like zinc finger	0	DIRECT
PX domain	0	DIRECT
Band 7/SPFH domain	0	DIRECT
Actin depolymerizing proteins	0	DIRECT
Clavaminate synthase-like	0	DIRECT
Polo-box domain	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
FAD-binding/transporter-associated domain-like	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Sm-like ribonucleoproteins	0	DIRECT
Nucleotide cyclase	0	DIRECT
Carboxypeptidase regulatory domain-like	0	DIRECT
Folate-binding domain	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
LDH C-terminal domain-like	0	DIRECT
Sema domain	0	DIRECT
Composite domain of metallo-dependent hydrolases	0	DIRECT
Spectrin repeat	0	DIRECT
WW domain	0	DIRECT
Class I glutamine amidotransferase-like	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
PABC (PABP) domain	0	DIRECT
DNA ligase/mRNA capping enzyme, catalytic domain	0	DIRECT
Tautomerase/MIF	0	DIRECT
Fibronectin type III	0	DIRECT
Ras GEF	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
Pseudouridine synthase	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Aminomethyltransferase beta-barrel domain	0	DIRECT
LysM domain	0	DIRECT
Spermadhesin, CUB domain	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
Tetraspanin	0	DIRECT
Cadherin-like	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
Roadblock/LC7 domain	0	DIRECT
Nudix	0	DIRECT
Acyl-CoA dehydrogenase NM domain-like	0	DIRECT
Hairpin loop containing domain-like	0	DIRECT
Troponin coil-coiled subunits	0	DIRECT
3-carboxy-cis,cis-mucoante lactonizing enzyme	0	DIRECT
DNA clamp	0	DIRECT
Acid phosphatase/Vanadium-dependent haloperoxidase	0	DIRECT
SET domain	0	DIRECT
LEM domain	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
Chitinase insertion domain	0	DIRECT
Bactericidal permeability-increasing protein, BPI	0	DIRECT
Nucleotide-binding domain	0	DIRECT
Small-conductance potassium channel	0	DIRECT
BPTI-like	0	DIRECT
MIT domain	0	DIRECT
Calpain large subunit, middle domain (domain III)	0	DIRECT
Formate/glycerate dehydrogenase catalytic domain-like	0	DIRECT
Galactose mutarotase-like	0	DIRECT
Outer arm dynein light chain 1	0	DIRECT
Tubulin C-terminal domain-like	0	DIRECT
6-phosphogluconate dehydrogenase C-terminal domain-like	0	DIRECT
HCP-like	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
NAD(P)-linked oxidoreductase	0	DIRECT
R3H domain	0	DIRECT
Subtilisin-like	0	DIRECT
beta-lactamase/transpeptidase-like	0	DIRECT
cAMP-binding domain-like	0	DIRECT
SGNH hydrolase	0	DIRECT
eIF1-like	0	DIRECT
Rhodanese/Cell cycle control phosphatase	0	DIRECT
HD-domain/PDEase-like	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
Class II aaRS and biotin synthetases	0	DIRECT
Translation proteins	0	DIRECT
Prefoldin	0	DIRECT
FF domain	0	DIRECT
PP2C-like	0	DIRECT
Translation proteins SH3-like domain	0	DIRECT
SCP-like	0	DIRECT
Thiamin diphosphate-binding fold (THDP-binding)	0	DIRECT
Calponin-homology domain, CH-domain	0	DIRECT
Thiolase-like	0	DIRECT
CBD9-like	0	DIRECT
p53-like transcription factors	0	DIRECT
Phosphoenolpyruvate/pyruvate domain	0	DIRECT
Heme-dependent catalase-like	0	DIRECT
HRDC-like	0	DIRECT
B-box zinc-binding domain	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
2Fe-2S ferredoxin-like	0	DIRECT
Tubby C-terminal domain-like	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
Citrate synthase	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
PK beta-barrel domain-like	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
SIS domain	0	DIRECT
LDL receptor-like module	0	DIRECT
Rhomboid-like	0	DIRECT
FabD/lysophospholipase-like	0	DIRECT
Aquaporin-like	0	DIRECT
YbiA-like	0	DIRECT
Metallo-dependent hydrolases	0	DIRECT
Protease propeptides/inhibitors	0	DIRECT
PGBD-like	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
PAP/OAS1 substrate-binding domain	0	DIRECT
lambda repressor-like DNA-binding domains	0	DIRECT
HMG-box	0	DIRECT
Frizzled cysteine-rich domain	0	DIRECT
GAS2 domain-like	0	DIRECT
Immunoglobulin	0	DIRECT
TIMP-like	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Multidrug resistance efflux transporter EmrE	0	DIRECT
Invertebrate chitin-binding proteins	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
Rap/Ran-GAP	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
YWTD domain	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
Transcription factor IIA (TFIIA), alpha-helical domain	0	DIRECT
Smc hinge domain	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
Glutathione synthetase ATP-binding domain-like	0	DIRECT
Ribosomal L27 protein-like	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
Growth factor receptor domain	0	DIRECT
Lipocalins	0	DIRECT
Clathrin adaptor appendage domain	0	DIRECT
SMAD MH1 domain	0	DIRECT
FAD-linked reductases, C-terminal domain	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
Acyl-CoA dehydrogenase C-terminal domain-like	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Cupredoxins	0	DIRECT
Sec7 domain	0	DIRECT
Ribosomal proteins S24e, L23 and L15e	0	DIRECT
CAD & PB1 domains	0	DIRECT
Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
Concanavalin A-like lectins/glucanases	0	DIRECT
AN1-like Zinc finger	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Plexin repeat	0	DIRECT
NHL repeat	0	DIRECT
Doublecortin (DC)	0	DIRECT
Bet v1-like	0	DIRECT
Ribosomal protein L1	0	DIRECT
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
UBA-like	0	DIRECT
SAICAR synthase-like	0	DIRECT
Terpenoid cyclases/Protein prenyltransferases	0	DIRECT
Adenine nucleotide alpha hydrolases-like	0	DIRECT
Thioesterase/thiol ester dehydrase-isomerase	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Ribosomal protein S10	0	DIRECT
GroEL equatorial domain-like	0	DIRECT
Ganglioside M2 (gm2) activator	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
Activating enzymes of the ubiquitin-like proteins	0	DIRECT
WGR domain-like	0	DIRECT
Ribosomal protein S18	0	DIRECT
L-aspartase-like	0	DIRECT
NAD kinase/diacylglycerol kinase-like	0	DIRECT
Annexin	0	DIRECT
Phoshotransferase/anion transport protein	0	DIRECT
Hemopexin-like domain	0	DIRECT
Flavoproteins	0	DIRECT
Galactose oxidase, central domain	0	DIRECT
alpha/beta knot	0	DIRECT
MgtE membrane domain-like	0	DIRECT
PIN domain-like	0	DIRECT
Cytochrome b5-like heme/steroid binding domain	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
Glycerol-3-phosphate (1)-acyltransferase	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	0	DIRECT
Bromodomain	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
SpoIIaa-like	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0	DIRECT
Elafin-like	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
Integrin domains	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
RmlC-like cupins	0	DIRECT
Acid proteases	0	DIRECT
ISP domain	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
Nucleotide-diphospho-sugar transferases	0	DIRECT
Mss4-like	0	DIRECT
Calcium ATPase, transduction domain A	0	DIRECT
Carbonic anhydrase	0	DIRECT
Chromo domain-like	0	DIRECT
NagB/RpiA/CoA transferase-like	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
Calcium ATPase, transmembrane domain M	0	DIRECT
Radical SAM enzymes	0	DIRECT
Molybdenum cofactor biosynthesis proteins	0	DIRECT
TK C-terminal domain-like	0	DIRECT
Kelch motif	0	DIRECT
Cap-Gly domain	0	DIRECT
Glycosyl hydrolase domain	0	DIRECT
Mitochondrial carrier	0	DIRECT
Cystatin/monellin	0	DIRECT
PR-1-like	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
Creatinase/prolidase N-terminal domain	0	DIRECT
Terpenoid synthases	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
GAT-like domain	0	DIRECT
RuvA domain 2-like	0	DIRECT
RCC1/BLIP-II	0	DIRECT
ClpP/crotonase	0	DIRECT
BSD domain-like	0	DIRECT
SAP domain	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
GYF domain	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
14-3-3 protein	0	DIRECT
Cyclophilin-like	0	DIRECT
Eukaryotic type KH-domain (KH-domain type I)	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
Calcium-dependent phosphotriesterase	0	DIRECT
Phosphoglycerate mutase-like	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
Oxysterol-binding protein-like	0	DIRECT
Tudor/PWWP/MBT	0	DIRECT
PUA domain-like	0	DIRECT
Metal cation-transporting ATPase, ATP-binding domain N	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
NTF2-like	0	DIRECT
Nop domain	0	DIRECT
Riboflavin synthase domain-like	0	DIRECT
PLC-like phosphodiesterases	0	DIRECT
Hormone receptor domain	0	DIRECT
Sec63 N-terminal domain-like	0	DIRECT
Tropomyosin	0	DIRECT
eIF4e-like	0	DIRECT
SAND domain-like	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
Hedgehog/intein (Hint) domain	0	DIRECT
MIR domain	0	DIRECT
SMAD/FHA domain	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
SPOC domain-like	0	DIRECT
ADC-like	0	DIRECT
SNARE-like	0	DIRECT
Putative DNA-binding domain	0	DIRECT
The spindle assembly checkpoint protein mad2	0	DIRECT
L domain-like	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
Complement control module/SCR domain	0	DIRECT
Metallo-hydrolase/oxidoreductase	0	DIRECT
Nucleic acid-binding proteins	0	DIRECT
PHM/PNGase F	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
Actin-like ATPase domain	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Rudiment single hybrid motif	0	DIRECT
WWE domain	0	DIRECT
Single hybrid motif	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
SNARE fusion complex	0	DIRECT
Lysozyme-like	0	DIRECT
Cystine-knot cytokines	0	DIRECT
Glutamine synthetase/guanido kinase	0	DIRECT
ABC transporter transmembrane region	0	DIRECT
Carbohydrate phosphatase	0	DIRECT
CoA-dependent acyltransferases	0	DIRECT
Acyl-CoA N-acyltransferases (Nat)	0	DIRECT
Aldolase	0	DIRECT
Purple acid phosphatase, N-terminal domain	0	DIRECT
Lipovitellin-phosvitin complex; beta-sheet shell regions	0	DIRECT
PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	DIRECT
HAD-like	0	DIRECT
SAM/Pointed domain	0	DIRECT
Osmotin, thaumatin-like protein	0	DIRECT
Ribokinase-like	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Pentein	0	DIRECT
Zinc beta-ribbon	0	DIRECT
ThrRS/AlaRS common domain	0	DIRECT
Ribulose-phoshate binding barrel	0	DIRECT
EGF/Laminin	0	DIRECT
Clc chloride channel	0	DIRECT
Ammonium transporter	0	DIRECT
Aminoacid dehydrogenase-like, N-terminal domain	0	DIRECT
DEATH domain	0	DIRECT
BAR/IMD domain-like	0	DIRECT
GroES-like	0	DIRECT
Periplasmic binding protein-like II	0	DIRECT
Arginase/deacetylase	0	DIRECT
Restriction endonuclease-like	0	DIRECT
Heme-dependent peroxidases	0	DIRECT
Carbon-nitrogen hydrolase	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
Cytidine deaminase-like	0	DIRECT
Second domain of FERM	0	DIRECT
Mitochondrial cytochrome c oxidase subunit VIc	0	DIRECT
Phospholipase A2, PLA2	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
Isocitrate/Isopropylmalate dehydrogenase-like	0	DIRECT
vWA-like	0	DIRECT
PLP-binding barrel	0	DIRECT
PreATP-grasp domain	0	DIRECT
AraD/HMP-PK domain-like	0	DIRECT
ENTH/VHS domain	0	DIRECT
alpha-helical ferredoxin	0	DIRECT
Chaperone J-domain	0	DIRECT
Diaminopimelate epimerase-like	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
SH3-domain	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
Cysteine-rich domain	0	DIRECT
RUN domain-like	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
PRTase-like	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
PYP-like sensor domain (PAS domain)	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
CRAL/TRIO domain	0	DIRECT
Nucleotidyltransferase	0	DIRECT
4Fe-4S ferredoxins	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
S-adenosyl-L-methionine-dependent methyltransferases	0	DIRECT
HSP20-like chaperones	0	DIRECT
ALDH-like	0	DIRECT
FtsH protease domain-like	0	DIRECT
Tricorn protease domain 2	0	DIRECT
ARM repeat	0.0775	INHERITED FROM: brood size variant || epithelial system physiology variant || germ cell physiology variant
RNA-binding domain, RBD	0.2109	INHERITED FROM: brood size variant || sterile F1
PapD-like	0.2415	INHERITED FROM: sterile progeny
Nicotinic receptor ligand binding domain-like	0.2685	INHERITED FROM: coelomocyte endocytosis defective || synaptic transmission variant || nervous system physiology variant || coelomocyte physiology variant || coelomic system physiology variant
Voltage-gated potassium channels	0.3168	INHERITED FROM: muscle cell activity variant
Neurotransmitter-gated ion-channel transmembrane pore	0.3217	INHERITED FROM: coelomocyte endocytosis defective || synaptic transmission variant || nervous system physiology variant || coelomocyte physiology variant || coelomic system physiology variant
Ubiquitin-like	0.3619	INHERITED FROM: body muscle dystrophy || muscle cell physiology variant || muscle system physiology variant
Metallo-dependent phosphatases	0.4289	INHERITED FROM: germ cell resistant ionizing radiation || radiation induced germ cell apoptosis variant
FYVE/PHD zinc finger	0.525	INHERITED FROM: transgenerational loss of fertility || coelomocyte endocytosis defective || coelomocyte physiology variant || coelomic system physiology variant
EF-hand	0.6168	INHERITED FROM: gonad sheath contractions variant || somatic gonad physiology variant || muscle cell physiology variant || somatic sheath physiology variant || muscle system physiology variant
WD40 repeat-like	0.6556	INHERITED FROM: brood size variant || reduced brood size || germ cell physiology variant
TPR-like	0.6803	INHERITED FROM: male gonad development variant
GTPase activation domain, GAP	0.7352	INHERITED FROM: muscle cell attachment variant || muscle system physiology variant
Saposin	0.7867	INHERITED FROM: germ cell ionizing radiation response variant || germ cell resistant ionizing radiation || radiation induced germ cell apoptosis variant
(Phosphotyrosine protein) phosphatases II	0.8143	INHERITED FROM: muscle cell attachment variant
P-loop containing nucleoside triphosphate hydrolases	0.844	INHERITED FROM: male gonad development variant || nervous system physiology variant || brood size variant || postsynaptic region physiology variant || germ cell physiology variant
"Winged helix" DNA-binding domain	0.8854	INHERITED FROM: male gonad development variant || germline mortal || muscle dystrophy || body muscle dystrophy
RING/U-box	0.9058	INHERITED FROM: germ cell hypersensitive ionizing radiation || germ cell ionizing radiation response variant
Lamin A/C globular tail domain	0.9466	INHERITED FROM: muscle system physiology variant
PLP-dependent transferases	0.9522	INHERITED FROM: germ cell resistant ionizing radiation || radiation induced germ cell apoptosis variant
Protein kinase-like (PK-like)	1	INHERITED FROM: body muscle dystrophy || muscle cell physiology variant || neuron physiology variant || muscle system physiology variant
SH2 domain	1	INHERITED FROM: muscle cell physiology variant || muscle cell attachment variant || muscle system physiology variant

Family domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
eIF1-like	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Roadblock/LC7 domain	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
NOL1/NOP2/sun	0	DIRECT
WWE domain	0	DIRECT
LEM domain	0	DIRECT
N-acetylglucosaminyltransferase I	0	DIRECT
Sir2 family of transcriptional regulators	0	DIRECT
GABA-aminotransferase-like	0	DIRECT
NagD-like	0	DIRECT
GHMP Kinase, N-terminal domain	0	DIRECT
5' to 3' exonuclease catalytic domain	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
RecA protein-like (ATPase-domain)	0	DIRECT
Glycogenin	0	DIRECT
Ras GEF	0	DIRECT
Glutamine synthetase catalytic domain	0	DIRECT
Ribonuclease H	0	DIRECT
SPRY domain	0	DIRECT
Multidomain sulfurtransferase (rhodanese)	0	DIRECT
Ammonium transporter	0	DIRECT
CBS-domain pair	0	DIRECT
Zf-UBP	0	DIRECT
Kix domain of CBP (creb binding protein)	0	DIRECT
Nitrogenase iron protein-like	0	DIRECT
Serine carboxypeptidase-like	0	DIRECT
FabD-like	0	DIRECT
Sec63 C-terminal domain-like	0	DIRECT
Adenosine/AMP deaminase	0	DIRECT
CoA-binding domain	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
Hermes transposase-like	0	DIRECT
Class II glutamine amidotransferases	0	DIRECT
Integrin A (or I) domain	0	DIRECT
Ribosomal protein S10	0	DIRECT
FYVE, a phosphatidylinositol-3-phosphate binding domain	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
Second domain of FERM	0	DIRECT
Smr domain	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
Translational machinery components	0	DIRECT
Clathrin adaptor core protein	0	DIRECT
WW domain	0	DIRECT
Formin homology 2 domain (FH2 domain)	0	DIRECT
Histone lysine methyltransferases	0	DIRECT
Acylamino-acid-releasing enzyme, C-terminal donain	0	DIRECT
ALDH-like	0	DIRECT
Class I alpha-1;2-mannosidase, catalytic domain	0	DIRECT
Sec7 domain	0	DIRECT
Transcriptional factor domain	0	DIRECT
N-acetyl transferase, NAT	0	DIRECT
DPP6 catalytic domain-like	0	DIRECT
Aminoacid dehydrogenase-like, C-terminal domain	0	DIRECT
Pancreatic carboxypeptidases	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
Astacin	0	DIRECT
PDI-like	0	DIRECT
Cation efflux protein transmembrane domain-like	0	DIRECT
Tim10/DDP	0	DIRECT
Fatty acid binding protein-like	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Mob1/phocein	0	DIRECT
Ribonuclease PH domain 1-like	0	DIRECT
Actin/HSP70	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
BEACH domain	0	DIRECT
L-aminoacid/polyamine oxidase	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
Purple acid phosphatase, N-terminal domain	0	DIRECT
RNA-polymerase beta-prime	0	DIRECT
Mitochondrial carrier	0	DIRECT
AMPK-beta glycogen binding domain-like	0	DIRECT
Intermediate filament protein, coiled coil region	0	DIRECT
Arylsulfatase	0	DIRECT
FCH domain	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
D-aminoacid oxidase, N-terminal domain	0	DIRECT
Formate/glycerate dehydrogenases, NAD-domain	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
Band 7/SPFH domain	0	DIRECT
Myosin rod fragments	0	DIRECT
14-3-3 protein	0	DIRECT
Cell cycle transcription factor e2f-dp	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain	0	DIRECT
Acireductone dioxygenase	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase PP module	0	DIRECT
HCDH C-domain-like	0	DIRECT
Purple acid phosphatase-like	0	DIRECT
Aminomethyltransferase folate-binding domain	0	DIRECT
AlkB-like	0	DIRECT
XPF/Rad1/Mus81 nuclease	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
Fungal lipases	0	DIRECT
Calmodulin-like	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
COMT-like	0	DIRECT
Ribokinase-like	0	DIRECT
Gamma-glutamyltranspeptidase-like	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
Ribosomal protein L18 and S11	0	DIRECT
HEAT repeat	0	DIRECT
La domain	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
Kelch motif	0	DIRECT
Dimeric isocitrate & isopropylmalate dehydrogenases	0	DIRECT
1,3-glucuronyltransferase	0	DIRECT
GYF domain	0	DIRECT
beta 1,4 galactosyltransferase (b4GalT1)	0	DIRECT
VHS domain	0	DIRECT
Small-conductance potassium channel	0	DIRECT
BSD domain	0	DIRECT
PhzC/PhzF-like	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Cadherin	0	DIRECT
EF-G/eEF-2 domains III and V	0	DIRECT
Synaptotagmin-like (S variant)	0	DIRECT
Elafin-like	0	DIRECT
Vertebrate phospholipase A2	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
B-box zinc-binding domain	0	DIRECT
Calcium ATPase, transmembrane domain M	0	DIRECT
Anticodon-binding domain of Class II aaRS	0	DIRECT
Autophagin-like	0	DIRECT
Protein prenyltransferases	0	DIRECT
PaaI/YdiI-like	0	DIRECT
Alcohol dehydrogenase-like, C-terminal domain	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
Hedgehog C-terminal (Hog) autoprocessing domain	0	DIRECT
CoA transferase alpha subunit-like	0	DIRECT
28-residue LRR	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Growth factor receptor domain	0	DIRECT
Ferredoxin domains from multidomain proteins	0	DIRECT
Clathrin coat assembly domain	0	DIRECT
Globins	0	DIRECT
Ubiquitin activating enzymes (UBA)	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
Cytidylyltransferase	0	DIRECT
LIM domain	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Tubulin, C-terminal domain	0	DIRECT
FtsH protease domain-like	0	DIRECT
SAM (sterile alpha motif) domain	0	DIRECT
Arginine methyltransferase	0	DIRECT
RNA editing terminal uridyl transferase 2, RET2, domain 2	0	DIRECT
Frizzled cysteine-rich domain	0	DIRECT
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain	0	DIRECT
beta-Lactamase/D-ala carboxypeptidase	0	DIRECT
FAD/NAD-linked reductases, N-terminal and central domains	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
Group II chaperonin (CCT, TRIC), apical domain	0	DIRECT
MIR domain	0	DIRECT
Glycerol kinase	0	DIRECT
YicI catalytic domain-like	0	DIRECT
Carboxypeptidase regulatory domain	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
Eukaryotic type KH-domain (KH-domain type I)	0	DIRECT
SAP domain	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains	0	DIRECT
LysM domain	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
BolA-like	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain	0	DIRECT
L-arabinose binding protein-like	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
Pyridoxal-dependent decarboxylase	0	DIRECT
PX domain	0	DIRECT
FHA domain	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
Armadillo repeat	0	DIRECT
Plexin repeat	0	DIRECT
acyl-CoA oxidase C-terminal domains	0	DIRECT
Inositol polyphosphate 5-phosphatase (IPP5)	0	DIRECT
Leukotriene A4 hydrolase catalytic domain	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
Adenylyl and guanylyl cyclase catalytic domain	0	DIRECT
SMAD MH1 domain	0	DIRECT
Phoshoinositide 3-kinase (PI3K), catalytic domain	0	DIRECT
Elongation factors	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
Amylase, catalytic domain	0	DIRECT
Mammalian PLC	0	DIRECT
TBP-associated factors, TAFs	0	DIRECT
H-NOX domain	0	DIRECT
Phosphatidylethanolamine binding protein	0	DIRECT
alpha-mannosidase	0	DIRECT
Internalin LRR domain	0	DIRECT
Nucleotide and nucleoside kinases	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
Serum paraoxonase/arylesterase 1, PON1	0	DIRECT
BC C-terminal domain-like	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
FF domain	0	DIRECT
Lipovitellin-phosvitin complex, superhelical domain	0	DIRECT
Gelsolin-like	0	DIRECT
Polypeptide N-acetylgalactosaminyltransferase 1, N-terminal domain	0	DIRECT
Ribosomal protein L1	0	DIRECT
Poly(A) polymerase, PAP, N-terminal domain	0	DIRECT
Class I glutamine amidotransferases (GAT)	0	DIRECT
6-phosphogluconate dehydrogenase-like, N-terminal domain	0	DIRECT
UDPGT-like	0	DIRECT
Chitinase insertion domain	0	DIRECT
Class I aldolase	0	DIRECT
YihX-like	0	DIRECT
Poly(A) polymerase, PAP, middle domain	0	DIRECT
Ngr ectodomain-like	0	DIRECT
Mo25 protein	0	DIRECT
UBC-related	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Complement control module/SCR domain	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
Phosphate binding protein-like	0	DIRECT
Chromo domain	0	DIRECT
Clc chloride channel	0	DIRECT
Reductases	0	DIRECT
Rv2717c-like	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
Rhomboid-like	0	DIRECT
Methionine aminopeptidase, insert domain	0	DIRECT
Cdc48 N-terminal domain-like	0	DIRECT
Caspase catalytic domain	0	DIRECT
Aminomethyltransferase beta-barrel domain	0	DIRECT
Pancreatic carboxypeptidase, activation domain	0	DIRECT
Pumilio repeat	0	DIRECT
Classic zinc finger, C2H2	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
PR-1-like	0	DIRECT
POU-specific domain	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
alpha-Amylases, C-terminal beta-sheet domain	0	DIRECT
SH3-domain	0	DIRECT
TAZ domain	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	0	DIRECT
BAR domain	0	DIRECT
RIO1-like kinases	0	DIRECT
Arylamine N-methyltransferase	0	DIRECT
Laminin-type module	0	DIRECT
Trunk domain of Sec23/24	0	DIRECT
LDL receptor-like module	0	DIRECT
CAT-like	0	DIRECT
ABC transporter transmembrane region	0	DIRECT
STAR domain	0	DIRECT
Ras-binding domain, RBD	0	DIRECT
Dual specificity phosphatase-like	0	DIRECT
PLC-like (P variant)	0	DIRECT
t-snare proteins	0	DIRECT
NLI interacting factor-like phosphatase	0	DIRECT
L30e/L7ae ribosomal proteins	0	DIRECT
Cell cycle control phosphatase, catalytic domain	0	DIRECT
Inositol polyphosphate kinase (IPK)	0	DIRECT
ARID domain	0	DIRECT
D-aminoacid oxidase-like	0	DIRECT
DNA replication initiator (cdc21/cdc54) N-terminal domain	0	DIRECT
beta-CASP RNA-metabolising hydrolases	0	DIRECT
SAND domain	0	DIRECT
Nop domain	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
Filamin repeat (rod domain)	0	DIRECT
Peptidylglycine alpha-hydroxylating monooxygenase, PHM	0	DIRECT
NTF2-like	0	DIRECT
FAD-linked reductases, N-terminal domain	0	DIRECT
Ubiquitin-related	0	DIRECT
Cofilin-like	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
Ricin B-like	0	DIRECT
Purine and uridine phosphorylases	0	DIRECT
ZZ domain	0	DIRECT
Serpins	0	DIRECT
Hormone receptor domain	0	DIRECT
Matrix metalloproteases, catalytic domain	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
PUA domain	0	DIRECT
Cystathionine synthase-like	0	DIRECT
Translation initiation factor eIF4e	0	DIRECT
Galectin (animal S-lectin)	0	DIRECT
Alcohol dehydrogenase-like, N-terminal domain	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
MFPT repeat	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
PDZ domain	0	DIRECT
Patatin	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	0	DIRECT
Fibronectin type III	0	DIRECT
MIF4G domain-like	0	DIRECT
Pleckstrin-homology domain (PH domain)	0	DIRECT
p120GAP domain-like	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
Family 19 glycosidase	0	DIRECT
MIF-related	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase Pyr module	0	DIRECT
LacY-like proton/sugar symporter	0	DIRECT
RNA methyltransferase FtsJ	0	DIRECT
Sec63 N-terminal domain	0	DIRECT
Cytoplasmic domain of inward rectifier potassium channel	0	DIRECT
Hemocyanin middle domain	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Doublecortin (DC)	0	DIRECT
BC ATP-binding domain-like	0	DIRECT
I set domains	0	DIRECT
Hect, E3 ligase catalytic domain	0	DIRECT
Biotinyl/lipoyl-carrier proteins and domains	0	DIRECT
Ribosomal protein S18	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
EGF-type module	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Phoshoinositide 3-kinase (PI3K) helical domain	0	DIRECT
Carbonic anhydrase	0	DIRECT
Trehalase-like	0	DIRECT
PDEase	0	DIRECT
Paired domain	0	DIRECT
Third domain of FERM	0	DIRECT
UDP-glucose pyrophosphorylase	0	DIRECT
Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
Chaperone J-domain	0	DIRECT
RNA-polymerase beta	0	DIRECT
Proprotein convertase P-domain	0	DIRECT
N-type ATP pyrophosphatases	0	DIRECT
Spectrin repeat	0	DIRECT
PABC (PABP) domain	0	DIRECT
Glycerol-3-phosphate transporter	0	DIRECT
Epoxide hydrolase	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
Guanido kinase catalytic domain	0	DIRECT
Calponin-homology domain, CH-domain	0	DIRECT
Crotonase-like	0	DIRECT
SNARE fusion complex	0	DIRECT
Poly(ADP-ribose) polymerase, C-terminal domain	0	DIRECT
GAS2 domain	0	DIRECT
Histone deacetylase, HDAC	0	DIRECT
LDH N-terminal domain-like	0	DIRECT
UBX domain	0	DIRECT
Spermadhesin, CUB domain	0	DIRECT
Eps15 homology domain (EH domain)	0	DIRECT
Tubulin, GTPase domain	0	DIRECT
HAT/Suf repeat	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
BC N-terminal domain-like	0	DIRECT
Tropomyosin	0	DIRECT
Catalytic, N-terminal domain of histone methyltransferase Dot1l	0	DIRECT
YWTD domain	0	DIRECT
Aquaporin-like	0	DIRECT
Smc hinge domain	0	DIRECT
SWIRM domain	0	DIRECT
Osmotin, thaumatin-like protein	0	DIRECT
Anticodon-binding domain	0	DIRECT
First domain of FERM	0	DIRECT
Kinase associated domain 1, KA1	0	DIRECT
Troponin I	0	DIRECT
WGR domain	0	DIRECT
Laminin G-like module	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
Acyl-carrier protein (ACP)	0	DIRECT
Lesion bypass DNA polymerase (Y-family), catalytic domain	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
PhyH-like	0	DIRECT
alpha-mannosidase, domain 2	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
Cytochrome b5	0	DIRECT
Heme-dependent catalases	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
Arfaptin, Rac-binding fragment	0	DIRECT
Acyl-CoA thioesterase	0	DIRECT
RhoGDI-like	0	DIRECT
CRAL/TRIO domain	0	DIRECT
CUT domain	0	DIRECT
Histidine acid phosphatase	0	DIRECT
Bacterial dinuclear zinc exopeptidases	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
Phosphotyrosine-binding domain (PTB)	0	DIRECT
MutT-like	0	DIRECT
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta	0	DIRECT
Sterol carrier protein, SCP	0	DIRECT
Transcription factor IIA (TFIIA), beta-barrel domain	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Cap-Gly domain	0	DIRECT
Annexin	0	DIRECT
Rap/Ran-GAP	0	DIRECT
Sm motif of small nuclear ribonucleoproteins, SNRNP	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
Polo-box duplicated region	0	DIRECT
4HBT-like	0	DIRECT
Choline kinase	0	DIRECT
U-box	0	DIRECT
ets domain	0	DIRECT
Lactate & malate dehydrogenases, C-terminal domain	0	DIRECT
Prefoldin	0	DIRECT
HMG-box	0	DIRECT
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain	0	DIRECT
Myeloperoxidase-like	0	DIRECT
YbiA-like	0	DIRECT
E2F dimerization segment	0	DIRECT
MIT domain	0	DIRECT
Calpain large subunit, catalytic domain (domain II)	0	DIRECT
Hsp90 middle domain	0	DIRECT
DEATH domain, DD	0	DIRECT
alpha-mannosidase, C-terminal domain	0	DIRECT
SMAD domain	0	DIRECT
Deoxycytidylate deaminase-like	0	DIRECT
Integrin domains	0	DIRECT
Hydantoinase (dihydropyrimidinase), catalytic domain	0	DIRECT
AraD-like aldolase/epimerase	0	DIRECT
Ypt/Rab-GAP domain of gyp1p	0	DIRECT
NHL repeat	0	DIRECT
Cold shock DNA-binding domain-like	0	DIRECT
ATI-like	0	DIRECT
Poly(A) polymerase, PAP, C-terminal domain	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Hemopexin-like domain	0	DIRECT
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)	0	DIRECT
RING finger domain, C3HC4	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
Choline/Carnitine O-acyltransferase	0	DIRECT
Phosphoribosyltransferases (PRTases)	0	DIRECT
UBA domain	0	DIRECT
Calpain large subunit, middle domain (domain III)	0	DIRECT
Ephrin ectodomain	0	DIRECT
DEP domain	0	DIRECT
beta-glycanases	0	DIRECT
TatD Mg-dependent DNase-like	0	DIRECT
2Fe-2S ferredoxin domains from multidomain proteins	0	DIRECT
CO dehydrogenase flavoprotein N-terminal domain-like	0	DIRECT
T-box	0	DIRECT
Brix domain	0	DIRECT
Tudor domain	0	DIRECT
Glutaminase	0	DIRECT
RUN domain	0	DIRECT
HSP20	0	DIRECT
Phoshatidylinositol transfer protein, PITP	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
Transcription factor IIA (TFIIA), alpha-helical domain	0	DIRECT
Small Kunitz-type inhibitors & BPTI-like toxins	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
ATP-dependent protease Lon (La), catalytic domain	0	DIRECT
cAMP-binding domain	0	DIRECT
Pyk2-associated protein beta ARF-GAP domain	0	DIRECT
Subtilases	0	DIRECT
Neurotransmitter-gated ion-channel transmembrane pore	0	DIRECT
Inositol monophosphatase/fructose-1,6-bisphosphatase-like	0	DIRECT
Neurolysin-like	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Calcium ATPase, transduction domain A	0	DIRECT
Biotin dependent carboxylase carboxyltransferase domain	0	DIRECT
NADPH-cytochrome p450 reductase FAD-binding domain-like	0	DIRECT
AN1-like Zinc finger	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
CCCH zinc finger	0	DIRECT
Bacterial lipase	0	DIRECT
Ganglioside M2 (gm2) activator	0	DIRECT
Adenain-like	0	DIRECT
F-box domain	0	DIRECT
alpha-catenin/vinculin	0	DIRECT
Hexokinase	0	DIRECT
Hydantoinase (dihydropyrimidinase)	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
Reprolysin-like	0	DIRECT
CalX-beta domain	0	DIRECT
Myotubularin-like phosphatases	0	DIRECT
Transforming growth factor (TGF)-beta	0	DIRECT
Regulator of chromosome condensation RCC1	0	DIRECT
Tetramerization domain of potassium channels	0	DIRECT
Ferredoxin reductase FAD-binding domain-like	0	DIRECT
BTB/POZ domain	0	DIRECT
Linker histone H1/H5	0	DIRECT
Papain-like	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
Metal cation-transporting ATPase, ATP-binding domain N	0	DIRECT
Pseudouridine synthase I TruA	0	DIRECT
IF2B-like	0	DIRECT
Aldo-keto reductases (NADP)	0	DIRECT
EF-hand modules in multidomain proteins	0	DIRECT
Citrate synthase	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
NADPH-cytochrome p450 reductase-like	0	DIRECT
Lipovitellin-phosvitin complex; beta-sheet shell regions	0	DIRECT
Tetraspanin	0	DIRECT
GAPDH-like	0	DIRECT
Group II chaperonin (CCT, TRIC), ATPase domain	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
PEP carboxykinase C-terminal domain	0	DIRECT
Type II chitinase	0	DIRECT
Bactericidal permeability-increasing protein, BPI	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Bromodomain	0	DIRECT
Cyclophilin (peptidylprolyl isomerase)	0	DIRECT
Gastric lipase	0	DIRECT
Erythroid transcription factor GATA-1	0	DIRECT
Myb/SANT domain	0	DIRECT
Pepsin-like	0	DIRECT
Proteasome subunits	0	DIRECT
Glycerophosphoryl diester phosphodiesterase	0	DIRECT
acyl-CoA oxidase N-terminal domains	0	DIRECT
PP2C-like	0	DIRECT
Single strand DNA-binding domain, SSB	0	DIRECT
Meta-cation ATPase, catalytic domain P	0	DIRECT
Carboxylesterase	0	DIRECT
Diap1 N-terninal region-like	0	DIRECT
Thiolase-related	0	DIRECT
HD domain	0	DIRECT
Sema domain	0	DIRECT
Oxysterol-binding protein	0	DIRECT
L domain	0	DIRECT
Canonical RBD	0.252	INHERITED FROM: brood size variant || sterile F1
Nicotinic receptor ligand binding domain-like	0.2736	INHERITED FROM: coelomocyte endocytosis defective || acetylcholine synaptic transmission variant || synaptic transmission variant || nervous system physiology variant || coelomocyte physiology variant || coelomic system physiology variant
MSP-like	0.2736	INHERITED FROM: sterile progeny
Voltage-gated potassium channels	0.3166	INHERITED FROM: muscle cell activity variant
Tandem AAA-ATPase domain	0.3268	INHERITED FROM: male fertility variant || male fertility reduced || male sterile
G proteins	0.4	INHERITED FROM: synaptic transmission variant || nervous system physiology variant || postsynaptic region physiology variant
BCR-homology GTPase activation domain (BH-domain)	0.7875	INHERITED FROM: muscle cell attachment variant || muscle system physiology variant
WD40-repeat	0.8033	INHERITED FROM: brood size variant || reduced brood size
Cyclin	0.8353	INHERITED FROM: male gonad development variant
Protein kinases, catalytic subunit	0.8924	INHERITED FROM: body muscle dystrophy || muscle cell physiology variant || neuron physiology variant || muscle system physiology variant
Motor proteins	0.951	INHERITED FROM: ciliated neuron physiology variant || nervous system physiology variant || neuron physiology variant
Lamin A/C globular tail domain	0.951	INHERITED FROM: muscle system physiology variant
Class I aminoacyl-tRNA synthetases (RS), catalytic domain	1	INHERITED FROM: receptor mediated endocytosis defective
SH2 domain	1	INHERITED FROM: muscle cell physiology variant || muscle cell attachment variant || muscle system physiology variant