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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

• Disease Ontology (DO) Ontology (DO)
  DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
  
• Human Phenotype (HP) Ontology (HP)
  HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
  
• Mouse Phenotype (MP) Ontology (MP)
  MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
  
• Worm Phenotype (WP) Ontology (WP)
  WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
  
• Yeast Phenotype (YP) Ontology (YP)
  Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
  
• Fly Phenotype (FP) Ontology (FP)
  FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
  
• Fly Anatomy (FA) Ontology (FA)
  FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
  
• Zebrafish Anatomy (ZA) Ontology (ZA)
  ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
  
• Xenopus Anatomy (XA) Ontology (XA)
  XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
  
• Arabidopsis Plant Ontology (AP) Ontology (AP)
  As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
  
• Enzyme Commission (EC) Ontology (EC)
  Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
  
• DrugBank ATC (DB) Ontology (DB)
  In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
  
• UniProtKB KeyWords (KW) Ontology (KW)
  Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
  
• UniProtKB UniPathway (UP) Ontology (UP)
  UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
  

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
  

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
  

Superfamily domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0	DIRECT
Hormone receptor domain	0	DIRECT
Metal cation-transporting ATPase, ATP-binding domain N	0	DIRECT
Spectrin repeat	0	DIRECT
PLP-binding barrel	0	DIRECT
Cytidine deaminase-like	0	DIRECT
Galactose-binding domain-like	0	DIRECT
Spermadhesin, CUB domain	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Acyl-CoA dehydrogenase NM domain-like	0	DIRECT
Phospholipase D/nuclease	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
Mitochondrial cytochrome c oxidase subunit VIc	0	DIRECT
Carbohydrate phosphatase	0	DIRECT
Pseudouridine synthase	0	DIRECT
Oxysterol-binding protein-like	0	DIRECT
CRAL/TRIO domain	0	DIRECT
NTF2-like	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
WWE domain	0	DIRECT
SMR domain-like	0	DIRECT
Acid phosphatase/Vanadium-dependent haloperoxidase	0	DIRECT
Single hybrid motif	0	DIRECT
t-snare proteins	0	DIRECT
LDH C-terminal domain-like	0	DIRECT
Acyl-CoA dehydrogenase C-terminal domain-like	0	DIRECT
Ribulose-phoshate binding barrel	0	DIRECT
Bactericidal permeability-increasing protein, BPI	0	DIRECT
Clc chloride channel	0	DIRECT
PHM/PNGase F	0	DIRECT
ACP-like	0	DIRECT
NagB/RpiA/CoA transferase-like	0	DIRECT
Transcription factor IIA (TFIIA), alpha-helical domain	0	DIRECT
RCC1/BLIP-II	0	DIRECT
cAMP-binding domain-like	0	DIRECT
Hairpin loop containing domain-like	0	DIRECT
SPOC domain-like	0	DIRECT
HIT/MYND zinc finger-like	0	DIRECT
Osmotin, thaumatin-like protein	0	DIRECT
MFPT repeat-like	0	DIRECT
MgtE membrane domain-like	0	DIRECT
Eukaryotic type KH-domain (KH-domain type I)	0	DIRECT
Sm-like ribonucleoproteins	0	DIRECT
BRCT domain	0	DIRECT
Metallo-hydrolase/oxidoreductase	0	DIRECT
Aminoacid dehydrogenase-like, N-terminal domain	0	DIRECT
Nop domain	0	DIRECT
14-3-3 protein	0	DIRECT
FAD/NAD(P)-binding domain	0	DIRECT
Nucleoporin domain	0	DIRECT
ARM repeat	0	DIRECT
Band 7/SPFH domain	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
TIMP-like	0	DIRECT
Cyclin-like	0	DIRECT
Annexin	0	DIRECT
Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
E2F-DP heterodimerization region	0	DIRECT
GYF domain	0	DIRECT
FAD-linked oxidases, C-terminal domain	0	DIRECT
CBD9-like	0	DIRECT
Lipovitellin-phosvitin complex; beta-sheet shell regions	0	DIRECT
Tim10-like	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
Apyrase	0	DIRECT
Zinc beta-ribbon	0	DIRECT
Actin depolymerizing proteins	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
HD-domain/PDEase-like	0	DIRECT
Pectin lyase-like	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
BAR/IMD domain-like	0	DIRECT
PYP-like sensor domain (PAS domain)	0	DIRECT
TGS-like	0	DIRECT
Sec7 domain	0	DIRECT
Ganglioside M2 (gm2) activator	0	DIRECT
Class I glutamine amidotransferase-like	0	DIRECT
Nucleotide-diphospho-sugar transferases	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
Rhomboid-like	0	DIRECT
LysM domain	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Metallo-dependent phosphatases	0	DIRECT
GAS2 domain-like	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
ThrRS/AlaRS common domain	0	DIRECT
PDZ domain-like	0	DIRECT
Polo-box domain	0	DIRECT
Intermediate filament protein, coiled coil region	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
Translation proteins SH3-like domain	0	DIRECT
Subdomain of clathrin and coatomer appendage domain	0	DIRECT
Folate-binding domain	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
alpha-helical ferredoxin	0	DIRECT
Restriction endonuclease-like	0	DIRECT
PUA domain-like	0	DIRECT
Metalloproteases ("zincins"), catalytic domain	0	DIRECT
C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
Glutamine synthetase/guanido kinase	0	DIRECT
Cadherin-like	0	DIRECT
Invertebrate chitin-binding proteins	0	DIRECT
Cyclophilin-like	0	DIRECT
Purine and uridine phosphorylases	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
FabD/lysophospholipase-like	0	DIRECT
GHMP Kinase, C-terminal domain	0	DIRECT
TK C-terminal domain-like	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0	DIRECT
NAD kinase/diacylglycerol kinase-like	0	DIRECT
TRAF domain-like	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
KA1-like	0	DIRECT
Bromodomain	0	DIRECT
Ammonium transporter	0	DIRECT
Purple acid phosphatase, N-terminal domain	0	DIRECT
Ypt/Rab-GAP domain of gyp1p	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
3-carboxy-cis,cis-mucoante lactonizing enzyme	0	DIRECT
Cap-Gly domain	0	DIRECT
PAZ domain	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
FAD-binding/transporter-associated domain-like	0	DIRECT
Ribosomal protein S10	0	DIRECT
WW domain	0	DIRECT
Alkaline phosphatase-like	0	DIRECT
MIT domain	0	DIRECT
DHS-like NAD/FAD-binding domain	0	DIRECT
Complement control module/SCR domain	0	DIRECT
DNase I-like	0	DIRECT
S-adenosyl-L-methionine-dependent methyltransferases	0	DIRECT
Roadblock/LC7 domain	0	DIRECT
Rap/Ran-GAP	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Proton glutamate symport protein	0	DIRECT
R3H domain	0	DIRECT
Sema domain	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
CCCH zinc finger	0	DIRECT
PEBP-like	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
UBA-like	0	DIRECT
PRTase-like	0	DIRECT
Carbon-nitrogen hydrolase	0	DIRECT
HRDC-like	0	DIRECT
SAM/Pointed domain	0	DIRECT
BSD domain-like	0	DIRECT
Cysteine-rich domain	0	DIRECT
ALDH-like	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
Actin-like ATPase domain	0	DIRECT
Hemopexin-like domain	0	DIRECT
Integrin alpha N-terminal domain	0	DIRECT
Plexin repeat	0	DIRECT
SAICAR synthase-like	0	DIRECT
RNI-like	0	DIRECT
Ras GEF	0	DIRECT
GroEL apical domain-like	0	DIRECT
Tautomerase/MIF	0	DIRECT
eIF4e-like	0	DIRECT
Di-copper centre-containing domain	0	DIRECT
Outer arm dynein light chain 1	0	DIRECT
FF domain	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
PEP carboxykinase-like	0	DIRECT
Cytochrome c	0	DIRECT
Bet v1-like	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
PLP-dependent transferases	0	DIRECT
CalX-like	0	DIRECT
Protease propeptides/inhibitors	0	DIRECT
Periplasmic binding protein-like II	0	DIRECT
Rudiment single hybrid motif	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Kix domain of CBP (creb binding protein)	0	DIRECT
Nucleotidyltransferase	0	DIRECT
VPS9 domain	0	DIRECT
beta-lactamase/transpeptidase-like	0	DIRECT
SMAD MH1 domain	0	DIRECT
PK beta-barrel domain-like	0	DIRECT
Glycosyl hydrolase domain	0	DIRECT
CoA-dependent acyltransferases	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Carboxypeptidase regulatory domain-like	0	DIRECT
GroEL equatorial domain-like	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Lysozyme-like	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
FtsH protease domain-like	0	DIRECT
Tropomyosin	0	DIRECT
Citrate synthase	0	DIRECT
Creatinase/prolidase N-terminal domain	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
Hect, E3 ligase catalytic domain	0	DIRECT
Second domain of FERM	0	DIRECT
HMG-box	0	DIRECT
Cation efflux protein transmembrane domain-like	0	DIRECT
Mss4-like	0	DIRECT
BolA-like	0	DIRECT
PAP/OAS1 substrate-binding domain	0	DIRECT
Sec63 N-terminal domain-like	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Thiamin diphosphate-binding fold (THDP-binding)	0	DIRECT
Adenine nucleotide alpha hydrolases-like	0	DIRECT
Actin-crosslinking proteins	0	DIRECT
Fibronectin type III	0	DIRECT
SGNH hydrolase	0	DIRECT
SAND domain-like	0	DIRECT
Ribosomal protein L1	0	DIRECT
ARID-like	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
AraD/HMP-PK domain-like	0	DIRECT
Troponin coil-coiled subunits	0	DIRECT
Glycerol-3-phosphate (1)-acyltransferase	0	DIRECT
CBS-domain pair	0	DIRECT
Translational machinery components	0	DIRECT
PIN domain-like	0	DIRECT
6-phosphogluconate dehydrogenase C-terminal domain-like	0	DIRECT
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
PR-1-like	0	DIRECT
Diaminopimelate epimerase-like	0	DIRECT
PH domain-like	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
DNA clamp	0	DIRECT
L domain-like	0	DIRECT
SNARE fusion complex	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
YbiA-like	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
Hedgehog/intein (Hint) domain	0	DIRECT
PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	DIRECT
Chaperone J-domain	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
ABC transporter transmembrane region	0	DIRECT
AN1-like Zinc finger	0	DIRECT
Cupredoxins	0	DIRECT
Composite domain of metallo-dependent hydrolases	0	DIRECT
TAZ domain	0	DIRECT
Lipovitellin-phosvitin complex, superhelical domain	0	DIRECT
Tubulin C-terminal domain-like	0	DIRECT
RUN domain-like	0	DIRECT
Smc hinge domain	0	DIRECT
Ferredoxin reductase-like, C-terminal NADP-linked domain	0	DIRECT
ClpP/crotonase	0	DIRECT
SAP domain	0	DIRECT
Tubulin nucleotide-binding domain-like	0	DIRECT
LuxS/MPP-like metallohydrolase	0	DIRECT
Nucleic acid-binding proteins	0	DIRECT
SpoIIaa-like	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
HCP-like	0	DIRECT
Galactose oxidase, central domain	0	DIRECT
Six-hairpin glycosidases	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
SH3-domain	0	DIRECT
Arginase/deacetylase	0	DIRECT
Thioesterase/thiol ester dehydrase-isomerase	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
Terpenoid synthases	0	DIRECT
Acid proteases	0	DIRECT
CAD & PB1 domains	0	DIRECT
ADC-like	0	DIRECT
Calpain large subunit, middle domain (domain III)	0	DIRECT
FAD-linked reductases, C-terminal domain	0	DIRECT
L30e-like	0	DIRECT
Nucleotide cyclase	0	DIRECT
Clathrin adaptor appendage domain	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
Caspase-like	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
Ribokinase-like	0	DIRECT
Formin homology 2 domain (FH2 domain)	0	DIRECT
Metallo-dependent hydrolases	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
Myosin rod fragments	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
Elafin-like	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	0	DIRECT
Integrin domains	0	DIRECT
Periplasmic binding protein-like I	0	DIRECT
SCP-like	0	DIRECT
The spindle assembly checkpoint protein mad2	0	DIRECT
Calcium ATPase, transduction domain A	0	DIRECT
B-box zinc-binding domain	0	DIRECT
RuvA domain 2-like	0	DIRECT
Chitinase insertion domain	0	DIRECT
Translation proteins	0	DIRECT
Cystatin/monellin	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
Cytochrome b5-like heme/steroid binding domain	0	DIRECT
ENTH/VHS domain	0	DIRECT
Serine protease inhibitors	0	DIRECT
Heme-dependent catalase-like	0	DIRECT
Immunoglobulin	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
Tricorn protease domain 2	0	DIRECT
Transcription factor IIA (TFIIA), beta-barrel domain	0	DIRECT
Galactose mutarotase-like	0	DIRECT
Activating enzymes of the ubiquitin-like proteins	0	DIRECT
Tetraspanin	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
4Fe-4S ferredoxins	0	DIRECT
NHL repeat	0	DIRECT
Serpins	0	DIRECT
HSP20-like chaperones	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
PX domain	0	DIRECT
Phosphoenolpyruvate/pyruvate domain	0	DIRECT
Calcium ATPase, transmembrane domain M	0	DIRECT
Clavaminate synthase-like	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
dsRNA-binding domain-like	0	DIRECT
Heme-dependent peroxidases	0	DIRECT
RmlC-like cupins	0	DIRECT
Phospholipase A2, PLA2	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
DNA ligase/mRNA capping enzyme, catalytic domain	0	DIRECT
HAD-like	0	DIRECT
Glutathione synthetase ATP-binding domain-like	0	DIRECT
ADP-ribosylation	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
SNARE-like	0	DIRECT
BEACH domain	0	DIRECT
SET domain	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Nudix	0	DIRECT
Mob1/phocein	0	DIRECT
Phosphoglycerate mutase-like	0	DIRECT
EF-G C-terminal domain-like	0	DIRECT
PP2C-like	0	DIRECT
Small-conductance potassium channel	0	DIRECT
alpha/beta knot	0	DIRECT
GAT-like domain	0	DIRECT
Prefoldin	0	DIRECT
Aldolase	0	DIRECT
Riboflavin synthase domain-like	0	DIRECT
SMAD/FHA domain	0	DIRECT
Rhodanese/Cell cycle control phosphatase	0	DIRECT
Formate/glycerate dehydrogenase catalytic domain-like	0	DIRECT
Glycoside hydrolase/deacetylase	0	DIRECT
LEM domain	0	DIRECT
Kringle-like	0	DIRECT
MIR domain	0	DIRECT
Kelch motif	0	DIRECT
Flavoproteins	0	DIRECT
BPTI-like	0	DIRECT
lambda repressor-like DNA-binding domains	0	DIRECT
DEATH domain	0	DIRECT
Ricin B-like lectins	0	DIRECT
ArfGap/RecO-like zinc finger	0	DIRECT
p53-like transcription factors	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
Tubby C-terminal domain-like	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
Carbonic anhydrase	0	DIRECT
UBC-like	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
Isocitrate/Isopropylmalate dehydrogenase-like	0	DIRECT
Mitochondrial carrier	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
SH2 domain	0	DIRECT
Multidrug resistance efflux transporter EmrE	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
Families 57/38 glycoside transferase middle domain	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
Radical SAM enzymes	0	DIRECT
Concanavalin A-like lectins/glucanases	0	DIRECT
GroES-like	0	DIRECT
Chromo domain-like	0	DIRECT
Putative DNA-binding domain	0	DIRECT
Phoshotransferase/anion transport protein	0	DIRECT
Calcium-dependent phosphotriesterase	0	DIRECT
PLC-like phosphodiesterases	0	DIRECT
SNF-like	0	DIRECT
Ribosomal proteins S24e, L23 and L15e	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
NAD(P)-linked oxidoreductase	0	DIRECT
Alpha-L RNA-binding motif	0	DIRECT
Frizzled cysteine-rich domain	0	DIRECT
Subtilisin-like	0	DIRECT
Doublecortin (DC)	0	DIRECT
Calponin-homology domain, CH-domain	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
PABC (PABP) domain	0	DIRECT
Ribosomal protein S18	0	DIRECT
SIS domain	0	DIRECT
2Fe-2S ferredoxin-like	0	DIRECT
eIF1-like	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
Pentein	0	DIRECT
Ankyrin repeat	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
Nucleotide-binding domain	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
Lipocalins	0	DIRECT
Terpenoid cyclases/Protein prenyltransferases	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
Molybdenum cofactor biosynthesis proteins	0	DIRECT
Aquaporin-like	0	DIRECT
Thiolase-like	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
L-aspartase-like	0	DIRECT
alpha-catenin/vinculin-like	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
Ferritin-like	0	DIRECT
PreATP-grasp domain	0	DIRECT
Aminomethyltransferase beta-barrel domain	0	DIRECT
PGBD-like	0	DIRECT
ISP domain	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
Acyl-CoA N-acyltransferases (Nat)	0	DIRECT
alpha/beta-Hydrolases	0	DIRECT
Tudor/PWWP/MBT	0	DIRECT
Cystine-knot cytokines	0	DIRECT
HIT-like	0	DIRECT
WGR domain-like	0	DIRECT
Protein kinase-like (PK-like)	0.1465	INHERITED FROM: muscle system physiology variant || muscle dystrophy || body muscle dystrophy
RNA-binding domain, RBD	0.3297	INHERITED FROM: sterile F1 || brood size variant
Nicotinic receptor ligand binding domain-like	0.401	INHERITED FROM: synaptic transmission variant || nervous system physiology variant
Neurotransmitter-gated ion-channel transmembrane pore	0.455	INHERITED FROM: synaptic transmission variant || nervous system physiology variant
Ubiquitin-like	0.4946	INHERITED FROM: muscle system physiology variant || muscle dystrophy || body muscle dystrophy
FYVE/PHD zinc finger	0.6483	INHERITED FROM: transgenerational loss of fertility
PapD-like	0.7157	INHERITED FROM: sterile progeny
EF-hand	0.7739	INHERITED FROM: somatic gonad physiology variant || gonad sheath contractions variant || somatic sheath physiology variant
"Winged helix" DNA-binding domain	0.787	INHERITED FROM: muscle system physiology variant || muscle dystrophy || body muscle dystrophy || brood size variant
WD40 repeat-like	0.84	INHERITED FROM: reduced brood size || brood size variant
EGF/Laminin	0.8447	INHERITED FROM: nervous system physiology variant
P-loop containing nucleoside triphosphate hydrolases	0.8623	INHERITED FROM: nervous system physiology variant || postsynaptic region physiology variant || brood size variant
LDL receptor-like module	1	INHERITED FROM: fertilization defective

Family domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Clathrin coat assembly domain	0	DIRECT
Oxysterol-binding protein	0	DIRECT
HMG-box	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Peptidylglycine alpha-hydroxylating monooxygenase, PHM	0	DIRECT
POU-specific domain	0	DIRECT
Translation initiation factor eIF4e	0	DIRECT
Chaperone J-domain	0	DIRECT
Hydantoinase (dihydropyrimidinase)	0	DIRECT
Nitrogenase iron protein-like	0	DIRECT
RIO1-like kinases	0	DIRECT
YihX-like	0	DIRECT
WWE domain	0	DIRECT
AAT-like	0	DIRECT
Methionine aminopeptidase, insert domain	0	DIRECT
Trunk domain of Sec23/24	0	DIRECT
Chitinase insertion domain	0	DIRECT
Small-conductance potassium channel	0	DIRECT
6-phosphogluconate dehydrogenase-like, N-terminal domain	0	DIRECT
H-NOX domain	0	DIRECT
Apyrase	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
Zf-UBP	0	DIRECT
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
LIM domain	0	DIRECT
Tropomyosin	0	DIRECT
Acyl-carrier protein (ACP)	0	DIRECT
Acireductone dioxygenase	0	DIRECT
CalX-beta domain	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
4HBT-like	0	DIRECT
28-residue LRR	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
Doublecortin (DC)	0	DIRECT
RecA protein-like (ATPase-domain)	0	DIRECT
Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
Osmotin, thaumatin-like protein	0	DIRECT
Alcohol dehydrogenase-like, N-terminal domain	0	DIRECT
Translational machinery components	0	DIRECT
GHMP Kinase, N-terminal domain	0	DIRECT
Kix domain of CBP (creb binding protein)	0	DIRECT
cAMP-binding domain	0	DIRECT
Cell cycle transcription factor e2f-dp	0	DIRECT
GAS2 domain	0	DIRECT
COMT-like	0	DIRECT
SWIRM domain	0	DIRECT
Formin homology 2 domain (FH2 domain)	0	DIRECT
Glutamine synthetase catalytic domain	0	DIRECT
PDEase	0	DIRECT
Troponin I	0	DIRECT
Acyl-CoA thioesterase	0	DIRECT
MFPT repeat	0	DIRECT
Arylsulfatase	0	DIRECT
BEACH domain	0	DIRECT
BC C-terminal domain-like	0	DIRECT
LysM domain	0	DIRECT
DPP6 catalytic domain-like	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
PDZ domain	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Protein prenyltransferases	0	DIRECT
BC N-terminal domain-like	0	DIRECT
Ganglioside M2 (gm2) activator	0	DIRECT
UBX domain	0	DIRECT
acyl-CoA oxidase C-terminal domains	0	DIRECT
Ribosomal protein L1	0	DIRECT
VHS domain	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase Pyr module	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
Sir2 family of transcriptional regulators	0	DIRECT
PR-1-like	0	DIRECT
Neurolysin-like	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
Lipovitellin-phosvitin complex; beta-sheet shell regions	0	DIRECT
Subtilases	0	DIRECT
Poly(ADP-ribose) polymerase, C-terminal domain	0	DIRECT
Guanido kinase catalytic domain	0	DIRECT
BolA-like	0	DIRECT
beta-glycanases	0	DIRECT
Poly(A) polymerase, PAP, C-terminal domain	0	DIRECT
Eps15 homology domain (EH domain)	0	DIRECT
Acylamino-acid-releasing enzyme, C-terminal donain	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
Third domain of FERM	0	DIRECT
NLI interacting factor-like phosphatase	0	DIRECT
Pseudouridine synthase I TruA	0	DIRECT
SNARE fusion complex	0	DIRECT
Purple acid phosphatase-like	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
Double-stranded RNA-binding domain (dsRBD)	0	DIRECT
SMAD MH1 domain	0	DIRECT
Sterol carrier protein, SCP	0	DIRECT
Thiolase-related	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
AraD-like aldolase/epimerase	0	DIRECT
Bacterial dinuclear zinc exopeptidases	0	DIRECT
MIF-related	0	DIRECT
Cell cycle control phosphatase, catalytic domain	0	DIRECT
Smr domain	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
Hemocyanin middle domain	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
Gastric lipase	0	DIRECT
Laminin-type module	0	DIRECT
Astacin	0	DIRECT
Frizzled cysteine-rich domain	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
Inositol polyphosphate kinase (IPK)	0	DIRECT
GAPDH-like	0	DIRECT
PhyH-like	0	DIRECT
PaaI/YdiI-like	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
14-3-3 protein	0	DIRECT
Hsp90 middle domain	0	DIRECT
Tetramerization domain of potassium channels	0	DIRECT
Ribosomal protein L18 and S11	0	DIRECT
Choline/Carnitine O-acyltransferase	0	DIRECT
t-snare proteins	0	DIRECT
Phosphatidylethanolamine binding protein	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Rhomboid-like	0	DIRECT
ALDH-like	0	DIRECT
UBC-related	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain	0	DIRECT
Nop domain	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Bromodomain	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Choline kinase	0	DIRECT
HEAT repeat	0	DIRECT
alpha-mannosidase, domain 2	0	DIRECT
Laminin G-like module	0	DIRECT
DEP domain	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
TatD Mg-dependent DNase-like	0	DIRECT
Ribokinase-like	0	DIRECT
Cdc48 N-terminal domain-like	0	DIRECT
BAR domain	0	DIRECT
Adenosine/AMP deaminase	0	DIRECT
D-aminoacid oxidase, N-terminal domain	0	DIRECT
Spermadhesin, CUB domain	0	DIRECT
Neutral endopeptidase (neprilysin)	0	DIRECT
RING finger domain, C3HC4	0	DIRECT
EF-G/eEF-2 domains III and V	0	DIRECT
Cystathionine synthase-like	0	DIRECT
Calponin-homology domain, CH-domain	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
BSD domain	0	DIRECT
Glycogenin	0	DIRECT
RNA editing terminal uridyl transferase 2, RET2, domain 2	0	DIRECT
Ngr ectodomain-like	0	DIRECT
Matrix metalloproteases, catalytic domain	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain	0	DIRECT
Biotinyl/lipoyl-carrier proteins and domains	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
Gelsolin-like	0	DIRECT
Cytochrome b5	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain	0	DIRECT
Calcium ATPase, transduction domain A	0	DIRECT
L-aminoacid/polyamine oxidase	0	DIRECT
Group II chaperonin (CCT, TRIC), ATPase domain	0	DIRECT
Glycerol-3-phosphate transporter	0	DIRECT
Reprolysin-like	0	DIRECT
NHL repeat	0	DIRECT
Hedgehog C-terminal (Hog) autoprocessing domain	0	DIRECT
Second domain of FERM	0	DIRECT
Hydantoinase (dihydropyrimidinase), catalytic domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
F-box domain	0	DIRECT
Formate/glycerate dehydrogenases, NAD-domain	0	DIRECT
Alcohol dehydrogenase-like, C-terminal domain	0	DIRECT
Phoshoinositide 3-kinase (PI3K) helical domain	0	DIRECT
Sec7 domain	0	DIRECT
L-arabinose binding protein-like	0	DIRECT
DNA replication initiator (cdc21/cdc54) N-terminal domain	0	DIRECT
IF2B-like	0	DIRECT
FHA domain	0	DIRECT
PX domain	0	DIRECT
Aminomethyltransferase beta-barrel domain	0	DIRECT
Plexin repeat	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
AN1-like Zinc finger	0	DIRECT
Calpain large subunit, catalytic domain (domain II)	0	DIRECT
Citrate synthase	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
Calcium ATPase, transmembrane domain M	0	DIRECT
Fibronectin type III	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
Eukaryotic type KH-domain (KH-domain type I)	0	DIRECT
RhoGDI-like	0	DIRECT
Regulator of chromosome condensation RCC1	0	DIRECT
Autophagin-like	0	DIRECT
Fungal lipases	0	DIRECT
Internalin LRR domain	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	0	DIRECT
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains	0	DIRECT
NADPH-cytochrome p450 reductase FAD-binding domain-like	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
Catalytic, N-terminal domain of histone methyltransferase Dot1l	0	DIRECT
FYVE, a phosphatidylinositol-3-phosphate binding domain	0	DIRECT
Galectin (animal S-lectin)	0	DIRECT
Ribonucleotide reductase-like	0	DIRECT
HSP20	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
Tetraspanin	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
PDI-like	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
Histone deacetylase, HDAC	0	DIRECT
Amylase, catalytic domain	0	DIRECT
E2F dimerization segment	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
Erythroid transcription factor GATA-1	0	DIRECT
NTF2-like	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
Cyclin	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
PP2C-like	0	DIRECT
Polo-box duplicated region	0	DIRECT
beta 1,4 galactosyltransferase (b4GalT1)	0	DIRECT
Phoshatidylinositol transfer protein, PITP	0	DIRECT
Sec63 C-terminal domain-like	0	DIRECT
YbiA-like	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
Single strand DNA-binding domain, SSB	0	DIRECT
Clc chloride channel	0	DIRECT
Ubiquitin-related	0	DIRECT
AlkB-like	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
Serine carboxypeptidase-like	0	DIRECT
NagD-like	0	DIRECT
Acetylcholinesterase-like	0	DIRECT
HD domain	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
Cytidylyltransferase	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
Bacterial lipase	0	DIRECT
SNF-like	0	DIRECT
Integrin domains	0	DIRECT
RNA-polymerase beta-prime	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
MATH domain	0	DIRECT
SAP domain	0	DIRECT
Cadherin	0	DIRECT
STAR domain	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase PP module	0	DIRECT
CCCH zinc finger	0	DIRECT
Neurotransmitter-gated ion-channel transmembrane pore	0	DIRECT
Class II glutamine amidotransferases	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Epoxide hydrolase	0	DIRECT
Tim10/DDP	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
Proteasome subunits	0	DIRECT
SH3-domain	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
CBS-domain pair	0	DIRECT
Ras GEF	0	DIRECT
PEP carboxykinase C-terminal domain	0	DIRECT
Kinase associated domain 1, KA1	0	DIRECT
Multidomain sulfurtransferase (rhodanese)	0	DIRECT
WW domain	0	DIRECT
Transcription factor IIA (TFIIA), alpha-helical domain	0	DIRECT
Poly(A) polymerase, PAP, N-terminal domain	0	DIRECT
T-box	0	DIRECT
Myosin rod fragments	0	DIRECT
2Fe-2S ferredoxin domains from multidomain proteins	0	DIRECT
Ribosomal protein S10	0	DIRECT
Ribosomal protein S18	0	DIRECT
RUN domain	0	DIRECT
Class I aldolase	0	DIRECT
Nucleotide and nucleoside kinases	0	DIRECT
Myeloperoxidase-like	0	DIRECT
Rv2717c-like	0	DIRECT
Ypt/Rab-GAP domain of gyp1p	0	DIRECT
5' to 3' exonuclease catalytic domain	0	DIRECT
Heme-dependent catalases	0	DIRECT
Anticodon-binding domain	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
Aquaporin-like	0	DIRECT
Ribonuclease PH domain 1-like	0	DIRECT
Mitochondrial carrier	0	DIRECT
XPF/Rad1/Mus81 nuclease	0	DIRECT
Ras-binding domain, RBD	0	DIRECT
Calmodulin-like	0	DIRECT
BTB/POZ domain	0	DIRECT
Bactericidal permeability-increasing protein, BPI	0	DIRECT
Hect, E3 ligase catalytic domain	0	DIRECT
Dimeric isocitrate & isopropylmalate dehydrogenases	0	DIRECT
LacY-like proton/sugar symporter	0	DIRECT
Small Kunitz-type inhibitors & BPTI-like toxins	0	DIRECT
YicI catalytic domain-like	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
Purine and uridine phosphorylases	0	DIRECT
Phosphate binding protein-like	0	DIRECT
Hermes transposase-like	0	DIRECT
Sm motif of small nuclear ribonucleoproteins, SNRNP	0	DIRECT
Carbonic anhydrase	0	DIRECT
Tubulin, C-terminal domain	0	DIRECT
Gamma-glutamyltranspeptidase-like	0	DIRECT
Lipovitellin-phosvitin complex, superhelical domain	0	DIRECT
Extended PAW domain	0	DIRECT
Hexokinase	0	DIRECT
Cap-Gly domain	0	DIRECT
N-acetylglucosaminyltransferase I	0	DIRECT
Proprotein convertase P-domain	0	DIRECT
Group II chaperonin (CCT, TRIC), apical domain	0	DIRECT
Annexin	0	DIRECT
CoA transferase alpha subunit-like	0	DIRECT
Smc hinge domain	0	DIRECT
Adenain-like	0	DIRECT
Pyk2-associated protein beta ARF-GAP domain	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
LDH N-terminal domain-like	0	DIRECT
beta-CASP RNA-metabolising hydrolases	0	DIRECT
Aldo-keto reductases (NADP)	0	DIRECT
First domain of FERM	0	DIRECT
NOL1/NOP2/sun	0	DIRECT
SH2 domain	0	DIRECT
WGR domain	0	DIRECT
Higher-molecular-weight phosphotyrosine protein phosphatases	0	DIRECT
Calpain large subunit, middle domain (domain III)	0	DIRECT
1,3-glucuronyltransferase	0	DIRECT
Glutaminase	0	DIRECT
Biotin dependent carboxylase carboxyltransferase domain	0	DIRECT
Pumilio repeat	0	DIRECT
Ribonuclease H	0	DIRECT
Kelch motif	0	DIRECT
Phoshoinositide 3-kinase (PI3K), catalytic domain	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
I set domains	0	DIRECT
Actin/HSP70	0	DIRECT
FCH domain	0	DIRECT
L domain	0	DIRECT
Reductases	0	DIRECT
Serum paraoxonase/arylesterase 1, PON1	0	DIRECT
Elongation factors	0	DIRECT
Aminomethyltransferase folate-binding domain	0	DIRECT
Arylamine N-methyltransferase	0	DIRECT
Class I glutamine amidotransferases (GAT)	0	DIRECT
Glycerol kinase	0	DIRECT
ets domain	0	DIRECT
Pancreatic carboxypeptidase, activation domain	0	DIRECT
NADPH-cytochrome p450 reductase-like	0	DIRECT
Mob1/phocein	0	DIRECT
Cofilin-like	0	DIRECT
Patatin	0	DIRECT
Meta-cation ATPase, catalytic domain P	0	DIRECT
SMAD domain	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
Linker histone H1/H5	0	DIRECT
Chromo domain	0	DIRECT
MPP-like	0	DIRECT
Rap/Ran-GAP	0	DIRECT
RNA-polymerase beta	0	DIRECT
Anticodon-binding domain of Class II aaRS	0	DIRECT
Protein serine/threonine phosphatase	0	DIRECT
Lactate & malate dehydrogenases, C-terminal domain	0	DIRECT
D-aminoacid oxidase-like	0	DIRECT
Adenylyl and guanylyl cyclase catalytic domain	0	DIRECT
Myb/SANT domain	0	DIRECT
Family 19 glycosidase	0	DIRECT
PAZ domain	0	DIRECT
Crotonase-like	0	DIRECT
Sec63 N-terminal domain	0	DIRECT
FAD/NAD-linked reductases, N-terminal and central domains	0	DIRECT
EF-hand modules in multidomain proteins	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
Polypeptide N-acetylgalactosaminyltransferase 1, N-terminal domain	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Purple acid phosphatase, N-terminal domain	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
N-type ATP pyrophosphatases	0	DIRECT
Sema domain	0	DIRECT
Synaptotagmin-like (S variant)	0	DIRECT
AMPK-beta glycogen binding domain-like	0	DIRECT
Ferredoxin domains from multidomain proteins	0	DIRECT
GABA-aminotransferase-like	0	DIRECT
Ankyrin repeat	0	DIRECT
Diap1 N-terninal region-like	0	DIRECT
Arginine methyltransferase	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
Prefoldin	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
LEM domain	0	DIRECT
MIT domain	0	DIRECT
N-acetyl transferase, NAT	0	DIRECT
Aminoacid dehydrogenase-like, C-terminal domain	0	DIRECT
FAD-linked reductases, N-terminal domain	0	DIRECT
Cold shock DNA-binding domain-like	0	DIRECT
Intermediate filament protein, coiled coil region	0	DIRECT
Poly(A) polymerase, PAP, middle domain	0	DIRECT
Leukotriene A4 hydrolase catalytic domain	0	DIRECT
eIF1-like	0	DIRECT
Pancreatic carboxypeptidases	0	DIRECT
SAND domain	0	DIRECT
Ferredoxin reductase FAD-binding domain-like	0	DIRECT
p120GAP domain-like	0	DIRECT
Lesion bypass DNA polymerase (Y-family), catalytic domain	0	DIRECT
TAZ domain	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Hormone receptor domain	0	DIRECT
MIR domain	0	DIRECT
Phosphotyrosine-binding domain (PTB)	0	DIRECT
Complement control module/SCR domain	0	DIRECT
HAT/Suf repeat	0	DIRECT
Inositol polyphosphate 5-phosphatase (IPP5)	0	DIRECT
Classic zinc finger, C2H2	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Type II chitinase	0	DIRECT
beta-Lactamase/D-ala carboxypeptidase	0	DIRECT
HCDH C-domain-like	0	DIRECT
SAM (sterile alpha motif) domain	0	DIRECT
SPRY domain	0	DIRECT
Myotubularin-like phosphatases	0	DIRECT
Hemopexin-like domain	0	DIRECT
ZZ domain	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
Cyclophilin (peptidylprolyl isomerase)	0	DIRECT
PABC (PABP) domain	0	DIRECT
Mammalian PLC	0	DIRECT
CRAL/TRIO domain	0	DIRECT
GYF domain	0	DIRECT
Transcriptional factor domain	0	DIRECT
Clathrin adaptor core protein	0	DIRECT
La domain	0	DIRECT
Ubiquitin activating enzymes (UBA)	0	DIRECT
alpha-catenin/vinculin	0	DIRECT
Papain-like	0	DIRECT
Carboxypeptidase regulatory domain	0	DIRECT
DEATH domain, DD	0	DIRECT
Band 7/SPFH domain	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
Serpins	0	DIRECT
Glycerophosphoryl diester phosphodiesterase	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
FF domain	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
CoA-binding domain	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
alpha-mannosidase, C-terminal domain	0	DIRECT
Transforming growth factor (TGF)-beta	0	DIRECT
CAT-like	0	DIRECT
PLC-like (P variant)	0	DIRECT
PhzC/PhzF-like	0	DIRECT
Metal cation-transporting ATPase, ATP-binding domain N	0	DIRECT
Roadblock/LC7 domain	0	DIRECT
BC ATP-binding domain-like	0	DIRECT
RNA methyltransferase FtsJ	0	DIRECT
Transcription factor IIA (TFIIA), beta-barrel domain	0	DIRECT
Integrin A (or I) domain	0	DIRECT
TBP-associated factors, TAFs	0	DIRECT
alpha-mannosidase	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Cation efflux protein transmembrane domain-like	0	DIRECT
Tubulin, GTPase domain	0	DIRECT
UDP-glucose pyrophosphorylase	0	DIRECT
FtsH protease domain-like	0	DIRECT
Fatty acid binding protein-like	0	DIRECT
U-box	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
Pyridoxal-dependent decarboxylase	0	DIRECT
Spectrin repeat	0	DIRECT
Ephrin ectodomain	0	DIRECT
Histidine acid phosphatase	0	DIRECT
MIF4G domain-like	0	DIRECT
Deoxycytidylate deaminase-like	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
MutT-like	0	DIRECT
Elafin-like	0	DIRECT
Filamin repeat (rod domain)	0	DIRECT
Inositol monophosphatase/fructose-1,6-bisphosphatase-like	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	0	DIRECT
Histone lysine methyltransferases	0	DIRECT
Trehalase-like	0	DIRECT
L30e/L7ae ribosomal proteins	0	DIRECT
Ammonium transporter	0	DIRECT
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Phosphoribosyltransferases (PRTases)	0	DIRECT
ABC transporter transmembrane region	0	DIRECT
Tudor domain	0	DIRECT
Ricin B-like	0	DIRECT
ATP-dependent protease Lon (La), catalytic domain	0	DIRECT
UDPGT-like	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
Dual specificity phosphatase-like	0	DIRECT
B-box zinc-binding domain	0	DIRECT
Cytoplasmic domain of inward rectifier potassium channel	0	DIRECT
alpha-Amylases, C-terminal beta-sheet domain	0	DIRECT
Carboxylesterase	0	DIRECT
Class I alpha-1;2-mannosidase, catalytic domain	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
ATI-like	0	DIRECT
Armadillo repeat	0	DIRECT
CUT domain	0	DIRECT
Paired domain	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
CO dehydrogenase flavoprotein N-terminal domain-like	0	DIRECT
Caspase catalytic domain	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
UBA domain	0	DIRECT
PUA domain	0	DIRECT
acyl-CoA oxidase N-terminal domains	0	DIRECT
ARID domain	0	DIRECT
Mo25 protein	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Arfaptin, Rac-binding fragment	0	DIRECT
Pepsin-like	0	DIRECT
Pleckstrin-homology domain (PH domain)	0	DIRECT
Protein kinases, catalytic subunit	0.08567	INHERITED FROM: muscle system physiology variant || sterile progeny || muscle dystrophy || body muscle dystrophy
C-type lectin domain	0.3048	INHERITED FROM: sterile progeny
Canonical RBD	0.367	INHERITED FROM: sterile F1 || brood size variant
Nicotinic receptor ligand binding domain-like	0.3973	INHERITED FROM: synaptic transmission variant || nervous system physiology variant
Tandem AAA-ATPase domain	0.4426	INHERITED FROM: male sterile || male fertility reduced || male fertility variant
G proteins	0.5015	INHERITED FROM: synaptic transmission variant || nervous system physiology variant || postsynaptic region physiology variant
MSP-like	0.6346	INHERITED FROM: sterile progeny
WD40-repeat	0.9358	INHERITED FROM: reduced brood size || dead eggs laid || brood size variant
LDL receptor-like module	0.9607	INHERITED FROM: fertilization defective