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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

• Disease Ontology (DO) Ontology (DO)
  DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
  
• Human Phenotype (HP) Ontology (HP)
  HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
  
• Mouse Phenotype (MP) Ontology (MP)
  MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
  
• Worm Phenotype (WP) Ontology (WP)
  WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
  
• Yeast Phenotype (YP) Ontology (YP)
  Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
  
• Fly Phenotype (FP) Ontology (FP)
  FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
  
• Fly Anatomy (FA) Ontology (FA)
  FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
  
• Zebrafish Anatomy (ZA) Ontology (ZA)
  ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
  
• Xenopus Anatomy (XA) Ontology (XA)
  XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
  
• Arabidopsis Plant Ontology (AP) Ontology (AP)
  As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
  
• Enzyme Commission (EC) Ontology (EC)
  Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
  
• DrugBank ATC (DB) Ontology (DB)
  In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
  
• UniProtKB KeyWords (KW) Ontology (KW)
  Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
  
• UniProtKB UniPathway (UP) Ontology (UP)
  UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
  

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
  

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
  

Superfamily domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
SCP-like	0	DIRECT
CAD & PB1 domains	0	DIRECT
Nudix	0	DIRECT
FtsH protease domain-like	0	DIRECT
Tubby C-terminal domain-like	0	DIRECT
Thioesterase/thiol ester dehydrase-isomerase	0	DIRECT
TK C-terminal domain-like	0	DIRECT
Ribosomal protein L1	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
Ribosomal proteins S24e, L23 and L15e	0	DIRECT
Purple acid phosphatase, N-terminal domain	0	DIRECT
Heme-dependent catalase-like	0	DIRECT
Sema domain	0	DIRECT
RUN domain-like	0	DIRECT
Hairpin loop containing domain-like	0	DIRECT
Ferritin-like	0	DIRECT
LysM domain	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
NHL repeat	0	DIRECT
CalX-like	0	DIRECT
Lipovitellin-phosvitin complex; beta-sheet shell regions	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
SGNH hydrolase	0	DIRECT
Cystatin/monellin	0	DIRECT
CBD9-like	0	DIRECT
Transcription factor IIA (TFIIA), beta-barrel domain	0	DIRECT
Multidrug resistance efflux transporter EmrE	0	DIRECT
Pectin lyase-like	0	DIRECT
Cation efflux protein transmembrane domain-like	0	DIRECT
SMAD/FHA domain	0	DIRECT
Alpha-L RNA-binding motif	0	DIRECT
Glycosyl hydrolase domain	0	DIRECT
SAM/Pointed domain	0	DIRECT
Galactose mutarotase-like	0	DIRECT
Mitochondrial cytochrome c oxidase subunit VIc	0	DIRECT
alpha-catenin/vinculin-like	0	DIRECT
AN1-like Zinc finger	0	DIRECT
MIR domain	0	DIRECT
Folate-binding domain	0	DIRECT
Ribosomal protein S18	0	DIRECT
Lysozyme-like	0	DIRECT
Formate/glycerate dehydrogenase catalytic domain-like	0	DIRECT
PUA domain-like	0	DIRECT
SH3-domain	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
alpha-helical ferredoxin	0	DIRECT
Thiolase-like	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
Cyclophilin-like	0	DIRECT
Calponin-homology domain, CH-domain	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
HRDC-like	0	DIRECT
Aminomethyltransferase beta-barrel domain	0	DIRECT
Carbohydrate phosphatase	0	DIRECT
PLC-like phosphodiesterases	0	DIRECT
Lipocalins	0	DIRECT
Integrin domains	0	DIRECT
Aquaporin-like	0	DIRECT
Tropomyosin	0	DIRECT
ADP-ribosylation	0	DIRECT
BSD domain-like	0	DIRECT
GroEL equatorial domain-like	0	DIRECT
SAND domain-like	0	DIRECT
t-snare proteins	0	DIRECT
ArfGap/RecO-like zinc finger	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
R3H domain	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
UBA-like	0	DIRECT
Immunoglobulin	0	DIRECT
Nucleotidyltransferase	0	DIRECT
ACP-like	0	DIRECT
Nucleic acid-binding proteins	0	DIRECT
Actin depolymerizing proteins	0	DIRECT
NAD(P)-linked oxidoreductase	0	DIRECT
PH domain-like	0	DIRECT
Bactericidal permeability-increasing protein, BPI	0	DIRECT
RuvA domain 2-like	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
Cysteine-rich domain	0	DIRECT
Carbon-nitrogen hydrolase	0	DIRECT
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
Osmotin, thaumatin-like protein	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
Chromo domain-like	0	DIRECT
Eukaryotic type KH-domain (KH-domain type I)	0	DIRECT
Phosphoglycerate mutase-like	0	DIRECT
PGBD-like	0	DIRECT
Glycerol-3-phosphate (1)-acyltransferase	0	DIRECT
AraD/HMP-PK domain-like	0	DIRECT
BAR/IMD domain-like	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Calcium ATPase, transmembrane domain M	0	DIRECT
ALDH-like	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Ribosomal L27 protein-like	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
beta-lactamase/transpeptidase-like	0	DIRECT
Calcium ATPase, transduction domain A	0	DIRECT
Ras GEF	0	DIRECT
Mitochondrial carrier	0	DIRECT
Acyl-CoA N-acyltransferases (Nat)	0	DIRECT
Di-copper centre-containing domain	0	DIRECT
Cupredoxins	0	DIRECT
ISP domain	0	DIRECT
SMR domain-like	0	DIRECT
Aldolase	0	DIRECT
SIS domain	0	DIRECT
3-carboxy-cis,cis-mucoante lactonizing enzyme	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
EF-G C-terminal domain-like	0	DIRECT
Thiamin diphosphate-binding fold (THDP-binding)	0	DIRECT
Galactose oxidase, central domain	0	DIRECT
Class I glutamine amidotransferase-like	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
MgtE membrane domain-like	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
ENTH/VHS domain	0	DIRECT
Families 57/38 glycoside transferase middle domain	0	DIRECT
EGF/Laminin	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
SNARE-like	0	DIRECT
CRAL/TRIO domain	0	DIRECT
DHS-like NAD/FAD-binding domain	0	DIRECT
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0	DIRECT
vWA-like	0	DIRECT
Activating enzymes of the ubiquitin-like proteins	0	DIRECT
Acyl-CoA dehydrogenase C-terminal domain-like	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Bet v1-like	0	DIRECT
CCCH zinc finger	0	DIRECT
RCC1/BLIP-II	0	DIRECT
Prefoldin	0	DIRECT
WGR domain-like	0	DIRECT
cAMP-binding domain-like	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
Kringle-like	0	DIRECT
4Fe-4S ferredoxins	0	DIRECT
Metal cation-transporting ATPase, ATP-binding domain N	0	DIRECT
Doublecortin (DC)	0	DIRECT
NAD kinase/diacylglycerol kinase-like	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0	DIRECT
Ricin B-like lectins	0	DIRECT
FabD/lysophospholipase-like	0	DIRECT
eIF4e-like	0	DIRECT
Citrate synthase	0	DIRECT
Class II aaRS and biotin synthetases	0	DIRECT
ClpP/crotonase	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
Phospholipase A2, PLA2	0	DIRECT
BolA-like	0	DIRECT
Terpenoid synthases	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
NTF2-like	0	DIRECT
Oxysterol-binding protein-like	0	DIRECT
TIMP-like	0	DIRECT
Aminoacid dehydrogenase-like, N-terminal domain	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
LEM domain	0	DIRECT
PHM/PNGase F	0	DIRECT
Alkaline phosphatase-like	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
Actin-like ATPase domain	0	DIRECT
PreATP-grasp domain	0	DIRECT
PLP-binding barrel	0	DIRECT
Mss4-like	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
6-phosphogluconate dehydrogenase C-terminal domain-like	0	DIRECT
FAD-linked reductases, C-terminal domain	0	DIRECT
PK beta-barrel domain-like	0	DIRECT
Calpain large subunit, middle domain (domain III)	0	DIRECT
Ypt/Rab-GAP domain of gyp1p	0	DIRECT
Phoshotransferase/anion transport protein	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
Tautomerase/MIF	0	DIRECT
VPS9 domain	0	DIRECT
Bromodomain	0	DIRECT
Glutamine synthetase/guanido kinase	0	DIRECT
Creatinase/prolidase N-terminal domain	0	DIRECT
Arginase/deacetylase	0	DIRECT
Tudor/PWWP/MBT	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
Cytidine deaminase-like	0	DIRECT
Complement control module/SCR domain	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
Spectrin repeat	0	DIRECT
L30e-like	0	DIRECT
The spindle assembly checkpoint protein mad2	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
SPOC domain-like	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
PP2C-like	0	DIRECT
Tim10-like	0	DIRECT
HIT-like	0	DIRECT
Cystine-knot cytokines	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
FAD-linked oxidases, C-terminal domain	0	DIRECT
Rap/Ran-GAP	0	DIRECT
Roadblock/LC7 domain	0	DIRECT
Kelch motif	0	DIRECT
PIN domain-like	0	DIRECT
BEACH domain	0	DIRECT
DEATH domain	0	DIRECT
p53-like transcription factors	0	DIRECT
YWTD domain	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
YbiA-like	0	DIRECT
Single hybrid motif	0	DIRECT
Lipovitellin-phosvitin complex, superhelical domain	0	DIRECT
Fibronectin type III	0	DIRECT
Nucleoporin domain	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
MFPT repeat-like	0	DIRECT
Ganglioside M2 (gm2) activator	0	DIRECT
GAS2 domain-like	0	DIRECT
Terpenoid cyclases/Protein prenyltransferases	0	DIRECT
SMAD MH1 domain	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
Tricorn protease domain 2	0	DIRECT
Hormone receptor domain	0	DIRECT
Phospholipase D/nuclease	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
Cytochrome b5-like heme/steroid binding domain	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
Carbonic anhydrase	0	DIRECT
B-box zinc-binding domain	0	DIRECT
Acid proteases	0	DIRECT
eIF1-like	0	DIRECT
Clavaminate synthase-like	0	DIRECT
Band 7/SPFH domain	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
ARID-like	0	DIRECT
Periplasmic binding protein-like I	0	DIRECT
Cap-Gly domain	0	DIRECT
Isocitrate/Isopropylmalate dehydrogenase-like	0	DIRECT
GAT-like domain	0	DIRECT
Calcium-dependent phosphotriesterase	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
alpha/beta knot	0	DIRECT
Sec63 N-terminal domain-like	0	DIRECT
Sec7 domain	0	DIRECT
HAD-like	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
Riboflavin synthase domain-like	0	DIRECT
Metallo-hydrolase/oxidoreductase	0	DIRECT
Phosphoenolpyruvate/pyruvate domain	0	DIRECT
14-3-3 protein	0	DIRECT
Nop domain	0	DIRECT
Tubulin nucleotide-binding domain-like	0	DIRECT
Rhodanese/Cell cycle control phosphatase	0	DIRECT
LDH C-terminal domain-like	0	DIRECT
Plexin repeat	0	DIRECT
Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
Carboxypeptidase regulatory domain-like	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
PR-1-like	0	DIRECT
Cytochrome c	0	DIRECT
HD-domain/PDEase-like	0	DIRECT
WW domain	0	DIRECT
ADC-like	0	DIRECT
LDL receptor-like module	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
Formin homology 2 domain (FH2 domain)	0	DIRECT
C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
FAD/NAD(P)-binding domain	0	DIRECT
Molybdenum cofactor biosynthesis proteins	0	DIRECT
PAP/OAS1 substrate-binding domain	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
TAZ domain	0	DIRECT
Flavoproteins	0	DIRECT
Subtilisin-like	0	DIRECT
Translation proteins SH3-like domain	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
GroES-like	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
Small-conductance potassium channel	0	DIRECT
Nucleotide cyclase	0	DIRECT
HSP20-like chaperones	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
CBS-domain pair	0	DIRECT
Integrin alpha N-terminal domain	0	DIRECT
E2F-DP heterodimerization region	0	DIRECT
lambda repressor-like DNA-binding domains	0	DIRECT
2Fe-2S ferredoxin-like	0	DIRECT
HIT/MYND zinc finger-like	0	DIRECT
BPTI-like	0	DIRECT
RmlC-like cupins	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
Nucleotide-diphospho-sugar transferases	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
Spermadhesin, CUB domain	0	DIRECT
Glycoside hydrolase/deacetylase	0	DIRECT
PABC (PABP) domain	0	DIRECT
Heme-dependent peroxidases	0	DIRECT
Transcription factor IIA (TFIIA), alpha-helical domain	0	DIRECT
SAICAR synthase-like	0	DIRECT
L domain-like	0	DIRECT
Rhomboid-like	0	DIRECT
Restriction endonuclease-like	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
Chitinase insertion domain	0	DIRECT
Clathrin adaptor appendage domain	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Adenine nucleotide alpha hydrolases-like	0	DIRECT
Radical SAM enzymes	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
S-adenosyl-L-methionine-dependent methyltransferases	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Hemopexin-like domain	0	DIRECT
Mob1/phocein	0	DIRECT
Clc chloride channel	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Tubulin C-terminal domain-like	0	DIRECT
Smc hinge domain	0	DIRECT
UBC-like	0	DIRECT
SpoIIaa-like	0	DIRECT
Serine protease inhibitors	0	DIRECT
PYP-like sensor domain (PAS domain)	0	DIRECT
Tetraspanin	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
Frizzled cysteine-rich domain	0	DIRECT
Periplasmic binding protein-like II	0	DIRECT
Chaperone J-domain	0	DIRECT
Caspase-like	0	DIRECT
Ribulose-phoshate binding barrel	0	DIRECT
Annexin	0	DIRECT
HCP-like	0	DIRECT
MIT domain	0	DIRECT
Class II aaRS ABD-related	0	DIRECT
PEBP-like	0	DIRECT
Concanavalin A-like lectins/glucanases	0	DIRECT
Putative DNA-binding domain	0	DIRECT
SAP domain	0	DIRECT
WWE domain	0	DIRECT
PDZ domain-like	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
Ammonium transporter	0	DIRECT
Zinc beta-ribbon	0	DIRECT
Pseudouridine synthase	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
Translation proteins	0	DIRECT
Myosin rod fragments	0	DIRECT
PRTase-like	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	0	DIRECT
Kix domain of CBP (creb binding protein)	0	DIRECT
Subdomain of clathrin and coatomer appendage domain	0	DIRECT
ABC transporter transmembrane region	0	DIRECT
Sm-like ribonucleoproteins	0	DIRECT
SNARE fusion complex	0	DIRECT
HMG-box	0	DIRECT
Pentein	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
FAD-binding/transporter-associated domain-like	0	DIRECT
Hedgehog/intein (Hint) domain	0	DIRECT
GHMP Kinase, C-terminal domain	0	DIRECT
Ankyrin repeat	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
Ribosomal protein S10	0	DIRECT
Acyl-CoA dehydrogenase NM domain-like	0	DIRECT
Intermediate filament protein, coiled coil region	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
GroEL apical domain-like	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
PX domain	0	DIRECT
Actin-crosslinking proteins	0	DIRECT
Second domain of FERM	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
Glutathione synthetase ATP-binding domain-like	0	DIRECT
GYF domain	0	DIRECT
Composite domain of metallo-dependent hydrolases	0	DIRECT
DNase I-like	0	DIRECT
Ferredoxin reductase-like, C-terminal NADP-linked domain	0	DIRECT
Growth factor receptor domain	0	DIRECT
Acid phosphatase/Vanadium-dependent haloperoxidase	0	DIRECT
PEP carboxykinase-like	0	DIRECT
TGS-like	0	DIRECT
Diaminopimelate epimerase-like	0	DIRECT
Troponin coil-coiled subunits	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
FF domain	0	DIRECT
Ribokinase-like	0	DIRECT
Polo-box domain	0	DIRECT
ThrRS/AlaRS common domain	0	DIRECT
Protease propeptides/inhibitors	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
BRCT domain	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
DNA clamp	0	DIRECT
SET domain	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
Translational machinery components	0	DIRECT
Invertebrate chitin-binding proteins	0	DIRECT
Rudiment single hybrid motif	0	DIRECT
L-aspartase-like	0	DIRECT
Hect, E3 ligase catalytic domain	0	DIRECT
DNA ligase/mRNA capping enzyme, catalytic domain	0	DIRECT
Outer arm dynein light chain 1	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Six-hairpin glycosidases	0	DIRECT
CoA-dependent acyltransferases	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
Elafin-like	0	DIRECT
Cadherin-like	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Metallo-dependent hydrolases	0	DIRECT
Nucleotide-binding domain	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
NagB/RpiA/CoA transferase-like	0	DIRECT
KA1-like	0	DIRECT
ARM repeat	0.08004	INHERITED FROM: germ cell physiology variant || brood size variant || epithelial system physiology variant
RNA-binding domain, RBD	0.2112	INHERITED FROM: sterile F1 || brood size variant
PapD-like	0.2487	INHERITED FROM: sterile progeny
Nicotinic receptor ligand binding domain-like	0.2761	INHERITED FROM: synaptic transmission variant || coelomic system physiology variant || coelomocyte uptake defective || transmission of nerve impulse variant || nervous system physiology variant || coelomocyte physiology variant
Voltage-gated potassium channels	0.3243	INHERITED FROM: muscle cell activity variant
Neurotransmitter-gated ion-channel transmembrane pore	0.329	INHERITED FROM: synaptic transmission variant || coelomic system physiology variant || coelomocyte uptake defective || transmission of nerve impulse variant || nervous system physiology variant || coelomocyte physiology variant
Ubiquitin-like	0.3699	INHERITED FROM: muscle system physiology variant || body muscle dystrophy || muscle cell physiology variant
Metallo-dependent phosphatases	0.4365	INHERITED FROM: germ cell resistant ionizing radiation || radiation induced germ cell apoptosis resistant
FYVE/PHD zinc finger	0.5315	INHERITED FROM: coelomic system physiology variant || coelomocyte uptake defective || transgenerational loss of fertility || coelomocyte physiology variant
EF-hand	0.625	INHERITED FROM: somatic gonad physiology variant || muscle system physiology variant || gonad sheath contractions variant || somatic sheath physiology variant || muscle cell physiology variant
WD40 repeat-like	0.6668	INHERITED FROM: germ cell physiology variant || brood size variant || reduced brood size
TPR-like	0.6882	INHERITED FROM: male gonad development variant
GTPase activation domain, GAP	0.7397	INHERITED FROM: muscle cell attachment variant || muscle system physiology variant || muscle cell physiology variant
P-loop containing nucleoside triphosphate hydrolases	0.7413	INHERITED FROM: germ cell physiology variant || brood size variant || male gonad development variant || postsynaptic region physiology variant || nervous system physiology variant
Saposin	0.7903	INHERITED FROM: germ cell ionizing radiation response variant || germ cell resistant ionizing radiation || radiation induced germ cell apoptosis resistant
(Phosphotyrosine protein) phosphatases II	0.8216	INHERITED FROM: muscle cell attachment variant
"Winged helix" DNA-binding domain	0.889	INHERITED FROM: male gonad development variant || body muscle dystrophy || muscle dystrophy || germline mortal
RING/U-box	0.9098	INHERITED FROM: germ cell hypersensitive ionizing radiation || germ cell ionizing radiation response variant
Lamin A/C globular tail domain	0.9465	INHERITED FROM: muscle system physiology variant
PLP-dependent transferases	0.9539	INHERITED FROM: germ cell resistant ionizing radiation || radiation induced germ cell apoptosis resistant
Protein kinase-like (PK-like)	1	INHERITED FROM: muscle system physiology variant || body muscle dystrophy || muscle cell physiology variant
SH2 domain	1	INHERITED FROM: muscle cell attachment variant || muscle system physiology variant || muscle cell physiology variant

Family domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Ribosomal protein S10	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
RNA-polymerase beta-prime	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
Sec7 domain	0	DIRECT
Carbonic anhydrase	0	DIRECT
XPF/Rad1/Mus81 nuclease	0	DIRECT
ZZ domain	0	DIRECT
Serum paraoxonase/arylesterase 1, PON1	0	DIRECT
Pepsin-like	0	DIRECT
L domain	0	DIRECT
RING finger domain, C3HC4	0	DIRECT
Armadillo repeat	0	DIRECT
Clc chloride channel	0	DIRECT
Troponin I	0	DIRECT
Phoshatidylinositol transfer protein, PITP	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
FabD-like	0	DIRECT
MutT-like	0	DIRECT
Matrix metalloproteases, catalytic domain	0	DIRECT
COMT-like	0	DIRECT
Roadblock/LC7 domain	0	DIRECT
Thiolase-related	0	DIRECT
Type II chitinase	0	DIRECT
Aminomethyltransferase folate-binding domain	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
Ribonuclease PH domain 1-like	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Sir2 family of transcriptional regulators	0	DIRECT
NADPH-cytochrome p450 reductase-like	0	DIRECT
FAD/NAD-linked reductases, N-terminal and central domains	0	DIRECT
CCCH zinc finger	0	DIRECT
POU-specific domain	0	DIRECT
Calpain large subunit, middle domain (domain III)	0	DIRECT
Fibronectin type III	0	DIRECT
Frizzled cysteine-rich domain	0	DIRECT
Guanido kinase catalytic domain	0	DIRECT
alpha-mannosidase	0	DIRECT
EF-G/eEF-2 domains III and V	0	DIRECT
YihX-like	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
Patatin	0	DIRECT
NTF2-like	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
Protein prenyltransferases	0	DIRECT
Kix domain of CBP (creb binding protein)	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Paired domain	0	DIRECT
VHS domain	0	DIRECT
GYF domain	0	DIRECT
AMPK-beta glycogen binding domain-like	0	DIRECT
U-box	0	DIRECT
D-aminoacid oxidase-like	0	DIRECT
ALDH-like	0	DIRECT
Proprotein convertase P-domain	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
H-NOX domain	0	DIRECT
NagD-like	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)	0	DIRECT
Hydantoinase (dihydropyrimidinase), catalytic domain	0	DIRECT
beta-Lactamase/D-ala carboxypeptidase	0	DIRECT
Elongation factors	0	DIRECT
Mob1/phocein	0	DIRECT
Pumilio repeat	0	DIRECT
Caspase catalytic domain	0	DIRECT
alpha-catenin/vinculin	0	DIRECT
Band 7/SPFH domain	0	DIRECT
Serpins	0	DIRECT
Hexokinase	0	DIRECT
Adenylyl and guanylyl cyclase catalytic domain	0	DIRECT
Oxysterol-binding protein	0	DIRECT
DPP6 catalytic domain-like	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
5' to 3' exonuclease catalytic domain	0	DIRECT
Cofilin-like	0	DIRECT
Ribonuclease H	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
CO dehydrogenase flavoprotein N-terminal domain-like	0	DIRECT
Gamma-glutamyltranspeptidase-like	0	DIRECT
LysM domain	0	DIRECT
Ypt/Rab-GAP domain of gyp1p	0	DIRECT
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain	0	DIRECT
FYVE, a phosphatidylinositol-3-phosphate binding domain	0	DIRECT
Mo25 protein	0	DIRECT
Chitinase insertion domain	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
F-box domain	0	DIRECT
Classic zinc finger, C2H2	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
FAD-linked reductases, N-terminal domain	0	DIRECT
Brix domain	0	DIRECT
Mitochondrial carrier	0	DIRECT
NHL repeat	0	DIRECT
Laminin-type module	0	DIRECT
Proteasome subunits	0	DIRECT
Group II chaperonin (CCT, TRIC), ATPase domain	0	DIRECT
Group II chaperonin (CCT, TRIC), apical domain	0	DIRECT
WW domain	0	DIRECT
E2F dimerization segment	0	DIRECT
Transcriptional factor domain	0	DIRECT
Inositol monophosphatase/fructose-1,6-bisphosphatase-like	0	DIRECT
Ribosomal protein L18 and S11	0	DIRECT
Dual specificity phosphatase-like	0	DIRECT
SAM (sterile alpha motif) domain	0	DIRECT
Histone lysine methyltransferases	0	DIRECT
Tetramerization domain of potassium channels	0	DIRECT
Bromodomain	0	DIRECT
Catalytic, N-terminal domain of histone methyltransferase Dot1l	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Ricin B-like	0	DIRECT
Ribokinase-like	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
Poly(ADP-ribose) polymerase, C-terminal domain	0	DIRECT
Actin/HSP70	0	DIRECT
CBS-domain pair	0	DIRECT
Integrin A (or I) domain	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
Fungal lipases	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Intermediate filament protein, coiled coil region	0	DIRECT
Clathrin coat assembly domain	0	DIRECT
Cytochrome b5	0	DIRECT
SMAD MH1 domain	0	DIRECT
CalX-beta domain	0	DIRECT
Plexin repeat	0	DIRECT
MIF-related	0	DIRECT
Transcription factor IIA (TFIIA), alpha-helical domain	0	DIRECT
BTB/POZ domain	0	DIRECT
Globins	0	DIRECT
Cdc48 N-terminal domain-like	0	DIRECT
Hsp90 middle domain	0	DIRECT
Class I alpha-1;2-mannosidase, catalytic domain	0	DIRECT
UBX domain	0	DIRECT
GAS2 domain	0	DIRECT
Lactate & malate dehydrogenases, C-terminal domain	0	DIRECT
Gastric lipase	0	DIRECT
Bacterial dinuclear zinc exopeptidases	0	DIRECT
Aldo-keto reductases (NADP)	0	DIRECT
CRAL/TRIO domain	0	DIRECT
Ganglioside M2 (gm2) activator	0	DIRECT
UBC-related	0	DIRECT
Calcium ATPase, transduction domain A	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
Spectrin repeat	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
Cytidylyltransferase	0	DIRECT
RecA protein-like (ATPase-domain)	0	DIRECT
Second domain of FERM	0	DIRECT
CoA-binding domain	0	DIRECT
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta	0	DIRECT
NOL1/NOP2/sun	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
6-phosphogluconate dehydrogenase-like, N-terminal domain	0	DIRECT
Transforming growth factor (TGF)-beta	0	DIRECT
IF2B-like	0	DIRECT
Cytoplasmic domain of inward rectifier potassium channel	0	DIRECT
Spermadhesin, CUB domain	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
LEM domain	0	DIRECT
Choline kinase	0	DIRECT
ATI-like	0	DIRECT
DEP domain	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	0	DIRECT
Multidomain sulfurtransferase (rhodanese)	0	DIRECT
Citrate synthase	0	DIRECT
Pancreatic carboxypeptidases	0	DIRECT
Phosphatidylethanolamine binding protein	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
Meta-cation ATPase, catalytic domain P	0	DIRECT
BAR domain	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
Histone deacetylase, HDAC	0	DIRECT
Deoxycytidylate deaminase-like	0	DIRECT
RhoGDI-like	0	DIRECT
Cap-Gly domain	0	DIRECT
CoA transferase alpha subunit-like	0	DIRECT
Phosphoribosyltransferases (PRTases)	0	DIRECT
Reductases	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
beta 1,4 galactosyltransferase (b4GalT1)	0	DIRECT
Cystathionine synthase-like	0	DIRECT
Small Kunitz-type inhibitors & BPTI-like toxins	0	DIRECT
Hemocyanin middle domain	0	DIRECT
I set domains	0	DIRECT
Hedgehog C-terminal (Hog) autoprocessing domain	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
Clathrin adaptor core protein	0	DIRECT
Vertebrate phospholipase A2	0	DIRECT
TBP-associated factors, TAFs	0	DIRECT
Alcohol dehydrogenase-like, N-terminal domain	0	DIRECT
CUT domain	0	DIRECT
Ferredoxin domains from multidomain proteins	0	DIRECT
Papain-like	0	DIRECT
Sec63 N-terminal domain	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
NLI interacting factor-like phosphatase	0	DIRECT
Ferredoxin reductase FAD-binding domain-like	0	DIRECT
SH3-domain	0	DIRECT
Nitrogenase iron protein-like	0	DIRECT
SWIRM domain	0	DIRECT
Sema domain	0	DIRECT
Translation initiation factor eIF4e	0	DIRECT
Tetraspanin	0	DIRECT
Calpain large subunit, catalytic domain (domain II)	0	DIRECT
PUA domain	0	DIRECT
YicI catalytic domain-like	0	DIRECT
Nucleotide and nucleoside kinases	0	DIRECT
alpha-Amylases, C-terminal beta-sheet domain	0	DIRECT
TatD Mg-dependent DNase-like	0	DIRECT
DNA replication initiator (cdc21/cdc54) N-terminal domain	0	DIRECT
Doublecortin (DC)	0	DIRECT
Cell cycle transcription factor e2f-dp	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
UBA domain	0	DIRECT
Trehalase-like	0	DIRECT
Aquaporin-like	0	DIRECT
RUN domain	0	DIRECT
Pseudouridine synthase I TruA	0	DIRECT
RNA methyltransferase FtsJ	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
N-acetylglucosaminyltransferase I	0	DIRECT
PLC-like (P variant)	0	DIRECT
Carboxypeptidase regulatory domain	0	DIRECT
Myotubularin-like phosphatases	0	DIRECT
acyl-CoA oxidase C-terminal domains	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
4HBT-like	0	DIRECT
Rap/Ran-GAP	0	DIRECT
Polo-box duplicated region	0	DIRECT
Integrin domains	0	DIRECT
PDI-like	0	DIRECT
RNA editing terminal uridyl transferase 2, RET2, domain 2	0	DIRECT
Cation efflux protein transmembrane domain-like	0	DIRECT
HAT/Suf repeat	0	DIRECT
B-box zinc-binding domain	0	DIRECT
Regulator of chromosome condensation RCC1	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
GABA-aminotransferase-like	0	DIRECT
Ribosomal protein S18	0	DIRECT
Phosphate binding protein-like	0	DIRECT
Serine carboxypeptidase-like	0	DIRECT
Tudor domain	0	DIRECT
Linker histone H1/H5	0	DIRECT
PhzC/PhzF-like	0	DIRECT
Smc hinge domain	0	DIRECT
TAZ domain	0	DIRECT
SAP domain	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
Arylsulfatase	0	DIRECT
SAND domain	0	DIRECT
p120GAP domain-like	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
HD domain	0	DIRECT
Reprolysin-like	0	DIRECT
SNARE fusion complex	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
L-arabinose binding protein-like	0	DIRECT
Phosphotyrosine-binding domain (PTB)	0	DIRECT
WGR domain	0	DIRECT
Pyk2-associated protein beta ARF-GAP domain	0	DIRECT
Calcium ATPase, transmembrane domain M	0	DIRECT
MIF4G domain-like	0	DIRECT
Glycogenin	0	DIRECT
AraD-like aldolase/epimerase	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
SPRY domain	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
L30e/L7ae ribosomal proteins	0	DIRECT
Eps15 homology domain (EH domain)	0	DIRECT
Osmotin, thaumatin-like protein	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
Histidine acid phosphatase	0	DIRECT
CAT-like	0	DIRECT
Tubulin, GTPase domain	0	DIRECT
Hydantoinase (dihydropyrimidinase)	0	DIRECT
Eukaryotic type KH-domain (KH-domain type I)	0	DIRECT
EF-hand modules in multidomain proteins	0	DIRECT
Bacterial lipase	0	DIRECT
Transcription factor IIA (TFIIA), beta-barrel domain	0	DIRECT
Ras GEF	0	DIRECT
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains	0	DIRECT
Fatty acid binding protein-like	0	DIRECT
Growth factor receptor domain	0	DIRECT
Astacin	0	DIRECT
Neurotransmitter-gated ion-channel transmembrane pore	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
DEATH domain, DD	0	DIRECT
Annexin	0	DIRECT
Class I aldolase	0	DIRECT
Erythroid transcription factor GATA-1	0	DIRECT
Polypeptide N-acetylgalactosaminyltransferase 1, N-terminal domain	0	DIRECT
Ankyrin repeat	0	DIRECT
EGF-type module	0	DIRECT
Cadherin	0	DIRECT
Ephrin ectodomain	0	DIRECT
N-type ATP pyrophosphatases	0	DIRECT
Lipovitellin-phosvitin complex; beta-sheet shell regions	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Sec63 C-terminal domain-like	0	DIRECT
Filamin repeat (rod domain)	0	DIRECT
Ribosomal protein L1	0	DIRECT
D-aminoacid oxidase, N-terminal domain	0	DIRECT
Peptidylglycine alpha-hydroxylating monooxygenase, PHM	0	DIRECT
Prefoldin	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
beta-glycanases	0	DIRECT
Kelch motif	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Class II glutamine amidotransferases	0	DIRECT
Family 19 glycosidase	0	DIRECT
Rhomboid-like	0	DIRECT
HEAT repeat	0	DIRECT
PP2C-like	0	DIRECT
UDPGT-like	0	DIRECT
Metal cation-transporting ATPase, ATP-binding domain N	0	DIRECT
PhyH-like	0	DIRECT
Formin homology 2 domain (FH2 domain)	0	DIRECT
Neurolysin-like	0	DIRECT
Ubiquitin-related	0	DIRECT
NADPH-cytochrome p450 reductase FAD-binding domain-like	0	DIRECT
Nop domain	0	DIRECT
Pyridoxal-dependent decarboxylase	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
PaaI/YdiI-like	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
Hect, E3 ligase catalytic domain	0	DIRECT
Tubulin, C-terminal domain	0	DIRECT
Choline/Carnitine O-acyltransferase	0	DIRECT
PABC (PABP) domain	0	DIRECT
Inositol polyphosphate 5-phosphatase (IPP5)	0	DIRECT
FCH domain	0	DIRECT
Bactericidal permeability-increasing protein, BPI	0	DIRECT
RIO1-like kinases	0	DIRECT
PDZ domain	0	DIRECT
alpha-mannosidase, domain 2	0	DIRECT
Sterol carrier protein, SCP	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase Pyr module	0	DIRECT
Ammonium transporter	0	DIRECT
Elafin-like	0	DIRECT
Biotinyl/lipoyl-carrier proteins and domains	0	DIRECT
14-3-3 protein	0	DIRECT
AN1-like Zinc finger	0	DIRECT
Ngr ectodomain-like	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
Cold shock DNA-binding domain-like	0	DIRECT
N-acetyl transferase, NAT	0	DIRECT
Aminoacid dehydrogenase-like, C-terminal domain	0	DIRECT
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Internalin LRR domain	0	DIRECT
Ubiquitin activating enzymes (UBA)	0	DIRECT
Synaptotagmin-like (S variant)	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
MIT domain	0	DIRECT
Formate/glycerate dehydrogenases, NAD-domain	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
GAPDH-like	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
1,3-glucuronyltransferase	0	DIRECT
Chaperone J-domain	0	DIRECT
Diap1 N-terninal region-like	0	DIRECT
Gelsolin-like	0	DIRECT
GHMP Kinase, N-terminal domain	0	DIRECT
Class I glutamine amidotransferases (GAT)	0	DIRECT
Galectin (animal S-lectin)	0	DIRECT
HMG-box	0	DIRECT
Purple acid phosphatase-like	0	DIRECT
Phoshoinositide 3-kinase (PI3K) helical domain	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
AlkB-like	0	DIRECT
eIF1-like	0	DIRECT
PX domain	0	DIRECT
PDEase	0	DIRECT
ATP-dependent protease Lon (La), catalytic domain	0	DIRECT
Trunk domain of Sec23/24	0	DIRECT
T-box	0	DIRECT
UDP-glucose pyrophosphorylase	0	DIRECT
Biotin dependent carboxylase carboxyltransferase domain	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
Ras-binding domain, RBD	0	DIRECT
Acyl-CoA thioesterase	0	DIRECT
Myeloperoxidase-like	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
Acireductone dioxygenase	0	DIRECT
Alcohol dehydrogenase-like, C-terminal domain	0	DIRECT
Hermes transposase-like	0	DIRECT
LacY-like proton/sugar symporter	0	DIRECT
Lesion bypass DNA polymerase (Y-family), catalytic domain	0	DIRECT
STAR domain	0	DIRECT
ABC transporter transmembrane region	0	DIRECT
Myosin rod fragments	0	DIRECT
Cyclophilin (peptidylprolyl isomerase)	0	DIRECT
Pancreatic carboxypeptidase, activation domain	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
Carboxylesterase	0	DIRECT
HSP20	0	DIRECT
alpha-mannosidase, C-terminal domain	0	DIRECT
RNA-polymerase beta	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
Phoshoinositide 3-kinase (PI3K), catalytic domain	0	DIRECT
LIM domain	0	DIRECT
Tropomyosin	0	DIRECT
Arylamine N-methyltransferase	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
PR-1-like	0	DIRECT
Zf-UBP	0	DIRECT
Pleckstrin-homology domain (PH domain)	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Purple acid phosphatase, N-terminal domain	0	DIRECT
Sm motif of small nuclear ribonucleoproteins, SNRNP	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Hemopexin-like domain	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase PP module	0	DIRECT
LDL receptor-like module	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Aminomethyltransferase beta-barrel domain	0	DIRECT
HCDH C-domain-like	0	DIRECT
28-residue LRR	0	DIRECT
FtsH protease domain-like	0	DIRECT
beta-CASP RNA-metabolising hydrolases	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
MFPT repeat	0	DIRECT
Subtilases	0	DIRECT
BC N-terminal domain-like	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Glycerol-3-phosphate transporter	0	DIRECT
MIR domain	0	DIRECT
Small-conductance potassium channel	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
Arfaptin, Rac-binding fragment	0	DIRECT
Lipovitellin-phosvitin complex, superhelical domain	0	DIRECT
Myb/SANT domain	0	DIRECT
Third domain of FERM	0	DIRECT
BC C-terminal domain-like	0	DIRECT
Smr domain	0	DIRECT
Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
YbiA-like	0	DIRECT
Glycerol kinase	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
L-aminoacid/polyamine oxidase	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
Rv2717c-like	0	DIRECT
BEACH domain	0	DIRECT
BC ATP-binding domain-like	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
SMAD domain	0	DIRECT
Acylamino-acid-releasing enzyme, C-terminal donain	0	DIRECT
BolA-like	0	DIRECT
Glycerophosphoryl diester phosphodiesterase	0	DIRECT
BSD domain	0	DIRECT
WWE domain	0	DIRECT
Dimeric isocitrate & isopropylmalate dehydrogenases	0	DIRECT
Methionine aminopeptidase, insert domain	0	DIRECT
Anticodon-binding domain	0	DIRECT
Tim10/DDP	0	DIRECT
Chromo domain	0	DIRECT
FF domain	0	DIRECT
t-snare proteins	0	DIRECT
Glutamine synthetase catalytic domain	0	DIRECT
Anticodon-binding domain of Class II aaRS	0	DIRECT
FHA domain	0	DIRECT
Acyl-carrier protein (ACP)	0	DIRECT
Arginine methyltransferase	0	DIRECT
Amylase, catalytic domain	0	DIRECT
PEP carboxykinase C-terminal domain	0	DIRECT
First domain of FERM	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Hormone receptor domain	0	DIRECT
ARID domain	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
La domain	0	DIRECT
Adenain-like	0	DIRECT
Heme-dependent catalases	0	DIRECT
Epoxide hydrolase	0	DIRECT
Laminin G-like module	0	DIRECT
Calmodulin-like	0	DIRECT
2Fe-2S ferredoxin domains from multidomain proteins	0	DIRECT
LDH N-terminal domain-like	0	DIRECT
Autophagin-like	0	DIRECT
Inositol polyphosphate kinase (IPK)	0	DIRECT
YWTD domain	0	DIRECT
Leukotriene A4 hydrolase catalytic domain	0	DIRECT
cAMP-binding domain	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Complement control module/SCR domain	0	DIRECT
Cell cycle control phosphatase, catalytic domain	0	DIRECT
ets domain	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
Glutaminase	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Mammalian PLC	0	DIRECT
Kinase associated domain 1, KA1	0	DIRECT
Crotonase-like	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain	0	DIRECT
Translational machinery components	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
acyl-CoA oxidase N-terminal domains	0	DIRECT
Calponin-homology domain, CH-domain	0	DIRECT
Single strand DNA-binding domain, SSB	0	DIRECT
Canonical RBD	0.2513	INHERITED FROM: sterile F1 || brood size variant
MSP-like	0.2803	INHERITED FROM: sterile progeny
Nicotinic receptor ligand binding domain-like	0.2803	INHERITED FROM: synaptic transmission variant || coelomic system physiology variant || coelomocyte uptake defective || transmission of nerve impulse variant || nervous system physiology variant || coelomocyte physiology variant
Voltage-gated potassium channels	0.3239	INHERITED FROM: muscle cell activity variant
Tandem AAA-ATPase domain	0.3341	INHERITED FROM: male fertility reduced || male sterile || male fertility variant
G proteins	0.4101	INHERITED FROM: synaptic transmission variant || postsynaptic region physiology variant || nervous system physiology variant
Homeodomain	0.6761	INHERITED FROM: nervous system physiology variant
BCR-homology GTPase activation domain (BH-domain)	0.7908	INHERITED FROM: muscle cell attachment variant || muscle system physiology variant
WD40-repeat	0.8104	INHERITED FROM: brood size variant || reduced brood size
Cyclin	0.8382	INHERITED FROM: male gonad development variant
Protein kinases, catalytic subunit	0.9024	INHERITED FROM: muscle system physiology variant || body muscle dystrophy || muscle cell physiology variant
Lamin A/C globular tail domain	0.9522	INHERITED FROM: muscle system physiology variant
Motor proteins	0.9535	INHERITED FROM: neuron physiology variant || ciliated neuron physiology variant || nervous system physiology variant
Class I aminoacyl-tRNA synthetases (RS), catalytic domain	1	INHERITED FROM: receptor mediated endocytosis defective
SH2 domain	1	INHERITED FROM: muscle cell attachment variant || muscle system physiology variant || muscle cell physiology variant