•  SEARCH

  • Keyword search
  • Sequence search
• 
  

•  BROWSE

  •   Organisms
  • Taxonomy
  • Statistics
  •   SCOP
  • Hierarchy
  •   Ontologies
  • GO
  • EC
  • Phenotype
• 
  

•  TOOLS

  • Compare genomes
  • Phylogenetic trees
  • Web services
  • Downloads
• 
  

•  ABOUT

  • Description
  • Publications
  • Documentation
• 
  

•  HELP

  • User support
  • Contact us
  • Email list
  • Sitemap

Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

• Disease Ontology (DO) Ontology (DO)
  DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
  
• Human Phenotype (HP) Ontology (HP)
  HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
  
• Mouse Phenotype (MP) Ontology (MP)
  MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
  
• Worm Phenotype (WP) Ontology (WP)
  WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
  
• Yeast Phenotype (YP) Ontology (YP)
  Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
  
• Fly Phenotype (FP) Ontology (FP)
  FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
  
• Fly Anatomy (FA) Ontology (FA)
  FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
  
• Zebrafish Anatomy (ZA) Ontology (ZA)
  ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
  
• Xenopus Anatomy (XA) Ontology (XA)
  XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
  
• Arabidopsis Plant Ontology (AP) Ontology (AP)
  As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
  
• Enzyme Commission (EC) Ontology (EC)
  Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
  
• DrugBank ATC (DB) Ontology (DB)
  In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
  
• UniProtKB KeyWords (KW) Ontology (KW)
  Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
  
• UniProtKB UniPathway (UP) Ontology (UP)
  UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
  

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
  

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
  

Superfamily domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Doublecortin (DC)	0	DIRECT
Ras GEF	0	DIRECT
GAT-like domain	0	DIRECT
SMR domain-like	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
NagB/RpiA/CoA transferase-like	0	DIRECT
Ricin B-like lectins	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
FF domain	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
ARID-like	0	DIRECT
Clavaminate synthase-like	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
Glutathione synthetase ATP-binding domain-like	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
Molybdenum cofactor biosynthesis proteins	0	DIRECT
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
Glycoside hydrolase/deacetylase	0	DIRECT
TK C-terminal domain-like	0	DIRECT
Arginase/deacetylase	0	DIRECT
Transcription factor IIA (TFIIA), beta-barrel domain	0	DIRECT
Tubby C-terminal domain-like	0	DIRECT
UBC-like	0	DIRECT
Annexin	0	DIRECT
Calponin-homology domain, CH-domain	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
FAD/NAD(P)-binding domain	0	DIRECT
Tetraspanin	0	DIRECT
Phosphoenolpyruvate/pyruvate domain	0	DIRECT
Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
FtsH protease domain-like	0	DIRECT
DNA ligase/mRNA capping enzyme, catalytic domain	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
Aldolase	0	DIRECT
HCP-like	0	DIRECT
DEATH domain	0	DIRECT
ADC-like	0	DIRECT
Ribosomal proteins S24e, L23 and L15e	0	DIRECT
PH domain-like	0	DIRECT
Tudor/PWWP/MBT	0	DIRECT
Cap-Gly domain	0	DIRECT
FAD-linked oxidases, C-terminal domain	0	DIRECT
4Fe-4S ferredoxins	0	DIRECT
alpha/beta knot	0	DIRECT
Tim10-like	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
Formate/glycerate dehydrogenase catalytic domain-like	0	DIRECT
PK beta-barrel domain-like	0	DIRECT
eIF4e-like	0	DIRECT
Thioesterase/thiol ester dehydrase-isomerase	0	DIRECT
Smc hinge domain	0	DIRECT
Acid phosphatase/Vanadium-dependent haloperoxidase	0	DIRECT
Pseudouridine synthase	0	DIRECT
WWE domain	0	DIRECT
Second domain of FERM	0	DIRECT
PX domain	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
Pentein	0	DIRECT
TAZ domain	0	DIRECT
Elafin-like	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
BPTI-like	0	DIRECT
Ganglioside M2 (gm2) activator	0	DIRECT
Invertebrate chitin-binding proteins	0	DIRECT
ALDH-like	0	DIRECT
ArfGap/RecO-like zinc finger	0	DIRECT
Cytochrome c	0	DIRECT
Carbon-nitrogen hydrolase	0	DIRECT
2Fe-2S ferredoxin-like	0	DIRECT
NAD(P)-linked oxidoreductase	0	DIRECT
Tropomyosin	0	DIRECT
GroES-like	0	DIRECT
t-snare proteins	0	DIRECT
CCCH zinc finger	0	DIRECT
Hairpin loop containing domain-like	0	DIRECT
E2F-DP heterodimerization region	0	DIRECT
Outer arm dynein light chain 1	0	DIRECT
Aminomethyltransferase beta-barrel domain	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
Lysozyme-like	0	DIRECT
Aquaporin-like	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
Ribosomal L27 protein-like	0	DIRECT
PIN domain-like	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
Lipovitellin-phosvitin complex, superhelical domain	0	DIRECT
Folate-binding domain	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
Rhomboid-like	0	DIRECT
Kix domain of CBP (creb binding protein)	0	DIRECT
Calcium ATPase, transmembrane domain M	0	DIRECT
Acid proteases	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
GroEL equatorial domain-like	0	DIRECT
Nucleotidyltransferase	0	DIRECT
Purine and uridine phosphorylases	0	DIRECT
Sema domain	0	DIRECT
Immunoglobulin	0	DIRECT
Proton glutamate symport protein	0	DIRECT
ClpP/crotonase	0	DIRECT
MIR domain	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
Plexin repeat	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Acyl-CoA dehydrogenase C-terminal domain-like	0	DIRECT
Thiamin diphosphate-binding fold (THDP-binding)	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
Prefoldin	0	DIRECT
WGR domain-like	0	DIRECT
ABC transporter transmembrane region	0	DIRECT
Metal cation-transporting ATPase, ATP-binding domain N	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
Aminoacid dehydrogenase-like, N-terminal domain	0	DIRECT
p53-like transcription factors	0	DIRECT
Band 7/SPFH domain	0	DIRECT
Ferritin-like	0	DIRECT
Diaminopimelate epimerase-like	0	DIRECT
FAD-binding/transporter-associated domain-like	0	DIRECT
Metallo-hydrolase/oxidoreductase	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0	DIRECT
Rap/Ran-GAP	0	DIRECT
HIT/MYND zinc finger-like	0	DIRECT
Carbohydrate phosphatase	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
alpha-helical ferredoxin	0	DIRECT
Chromo domain-like	0	DIRECT
SMAD/FHA domain	0	DIRECT
Actin-crosslinking proteins	0	DIRECT
LDH C-terminal domain-like	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
Nudix	0	DIRECT
NHL repeat	0	DIRECT
RUN domain-like	0	DIRECT
Calcium ATPase, transduction domain A	0	DIRECT
LEM domain	0	DIRECT
Citrate synthase	0	DIRECT
WW domain	0	DIRECT
YWTD domain	0	DIRECT
MgtE membrane domain-like	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
Lipocalins	0	DIRECT
C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
ENTH/VHS domain	0	DIRECT
Calpain large subunit, middle domain (domain III)	0	DIRECT
Bactericidal permeability-increasing protein, BPI	0	DIRECT
Cupredoxins	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
ADP-ribosylation	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
Bromodomain	0	DIRECT
Terpenoid cyclases/Protein prenyltransferases	0	DIRECT
Metallo-dependent hydrolases	0	DIRECT
RmlC-like cupins	0	DIRECT
Hedgehog/intein (Hint) domain	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
L domain-like	0	DIRECT
Lipovitellin-phosvitin complex; beta-sheet shell regions	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
Alpha-L RNA-binding motif	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
PR-1-like	0	DIRECT
Multidrug resistance efflux transporter EmrE	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
lambda repressor-like DNA-binding domains	0	DIRECT
SNARE-like	0	DIRECT
DNase I-like	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
Translation proteins SH3-like domain	0	DIRECT
Frizzled cysteine-rich domain	0	DIRECT
Ypt/Rab-GAP domain of gyp1p	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
Periplasmic binding protein-like II	0	DIRECT
Class I glutamine amidotransferase-like	0	DIRECT
CBD9-like	0	DIRECT
Kringle-like	0	DIRECT
Chaperone J-domain	0	DIRECT
Ammonium transporter	0	DIRECT
Class II aaRS ABD-related	0	DIRECT
PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	DIRECT
PUA domain-like	0	DIRECT
SET domain	0	DIRECT
Carbonic anhydrase	0	DIRECT
CAD & PB1 domains	0	DIRECT
Hormone receptor domain	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
SIS domain	0	DIRECT
Heme-dependent catalase-like	0	DIRECT
PDZ domain-like	0	DIRECT
Osmotin, thaumatin-like protein	0	DIRECT
Cytochrome b5-like heme/steroid binding domain	0	DIRECT
Phoshotransferase/anion transport protein	0	DIRECT
ACP-like	0	DIRECT
HSP20-like chaperones	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
KA1-like	0	DIRECT
14-3-3 protein	0	DIRECT
Nucleotide-diphospho-sugar transferases	0	DIRECT
Complement control module/SCR domain	0	DIRECT
Radical SAM enzymes	0	DIRECT
VPS9 domain	0	DIRECT
Families 57/38 glycoside transferase middle domain	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Class II aaRS and biotin synthetases	0	DIRECT
Purple acid phosphatase, N-terminal domain	0	DIRECT
Mob1/phocein	0	DIRECT
Isocitrate/Isopropylmalate dehydrogenase-like	0	DIRECT
MIT domain	0	DIRECT
Zinc beta-ribbon	0	DIRECT
alpha-catenin/vinculin-like	0	DIRECT
Oxysterol-binding protein-like	0	DIRECT
Cystatin/monellin	0	DIRECT
Polo-box domain	0	DIRECT
PLP-binding barrel	0	DIRECT
Riboflavin synthase domain-like	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
Concanavalin A-like lectins/glucanases	0	DIRECT
Intermediate filament protein, coiled coil region	0	DIRECT
Small-conductance potassium channel	0	DIRECT
GYF domain	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
LysM domain	0	DIRECT
Glycerol-3-phosphate (1)-acyltransferase	0	DIRECT
Integrin alpha N-terminal domain	0	DIRECT
Ribosomal protein L1	0	DIRECT
BAR/IMD domain-like	0	DIRECT
Roadblock/LC7 domain	0	DIRECT
L-aspartase-like	0	DIRECT
Terpenoid synthases	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Galactose mutarotase-like	0	DIRECT
Cadherin-like	0	DIRECT
PEBP-like	0	DIRECT
CBS-domain pair	0	DIRECT
BEACH domain	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
RuvA domain 2-like	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
GHMP Kinase, C-terminal domain	0	DIRECT
Mitochondrial carrier	0	DIRECT
SpoIIaa-like	0	DIRECT
Di-copper centre-containing domain	0	DIRECT
Troponin coil-coiled subunits	0	DIRECT
PLC-like phosphodiesterases	0	DIRECT
Clc chloride channel	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
Spectrin repeat	0	DIRECT
Composite domain of metallo-dependent hydrolases	0	DIRECT
beta-lactamase/transpeptidase-like	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
Sec63 N-terminal domain-like	0	DIRECT
Activating enzymes of the ubiquitin-like proteins	0	DIRECT
FAD-linked reductases, C-terminal domain	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
ISP domain	0	DIRECT
Six-hairpin glycosidases	0	DIRECT
Nop domain	0	DIRECT
SMAD MH1 domain	0	DIRECT
HIT-like	0	DIRECT
MFPT repeat-like	0	DIRECT
Subdomain of clathrin and coatomer appendage domain	0	DIRECT
Calcium-dependent phosphotriesterase	0	DIRECT
ThrRS/AlaRS common domain	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
PreATP-grasp domain	0	DIRECT
vWA-like	0	DIRECT
Tautomerase/MIF	0	DIRECT
Cytidine deaminase-like	0	DIRECT
Adenine nucleotide alpha hydrolases-like	0	DIRECT
SAP domain	0	DIRECT
3-carboxy-cis,cis-mucoante lactonizing enzyme	0	DIRECT
DNA clamp	0	DIRECT
Cystine-knot cytokines	0	DIRECT
Creatinase/prolidase N-terminal domain	0	DIRECT
NTF2-like	0	DIRECT
Ribokinase-like	0	DIRECT
LDL receptor-like module	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
BSD domain-like	0	DIRECT
Hect, E3 ligase catalytic domain	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Protease propeptides/inhibitors	0	DIRECT
Clathrin adaptor appendage domain	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
Translational machinery components	0	DIRECT
Fibronectin type III	0	DIRECT
Eukaryotic type KH-domain (KH-domain type I)	0	DIRECT
BolA-like	0	DIRECT
Actin depolymerizing proteins	0	DIRECT
PYP-like sensor domain (PAS domain)	0	DIRECT
eIF1-like	0	DIRECT
CalX-like	0	DIRECT
Phospholipase A2, PLA2	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
AN1-like Zinc finger	0	DIRECT
SAICAR synthase-like	0	DIRECT
Subtilisin-like	0	DIRECT
SPOC domain-like	0	DIRECT
SAM/Pointed domain	0	DIRECT
Nucleic acid-binding proteins	0	DIRECT
Chitinase insertion domain	0	DIRECT
Kelch motif	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
DHS-like NAD/FAD-binding domain	0	DIRECT
Flavoproteins	0	DIRECT
Ribosomal protein S18	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0	DIRECT
Spermadhesin, CUB domain	0	DIRECT
Galactose oxidase, central domain	0	DIRECT
Heme-dependent peroxidases	0	DIRECT
Acyl-CoA N-acyltransferases (Nat)	0	DIRECT
CoA-dependent acyltransferases	0	DIRECT
TIMP-like	0	DIRECT
SAND domain-like	0	DIRECT
Phosphoglycerate mutase-like	0	DIRECT
AraD/HMP-PK domain-like	0	DIRECT
Translation proteins	0	DIRECT
Ferredoxin reductase-like, C-terminal NADP-linked domain	0	DIRECT
PGBD-like	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
B-box zinc-binding domain	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
Tubulin C-terminal domain-like	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
Caspase-like	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Glycosyl hydrolase domain	0	DIRECT
Nucleoporin domain	0	DIRECT
Growth factor receptor domain	0	DIRECT
FabD/lysophospholipase-like	0	DIRECT
Putative DNA-binding domain	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
Mss4-like	0	DIRECT
HMG-box	0	DIRECT
GroEL apical domain-like	0	DIRECT
PABC (PABP) domain	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Serine protease inhibitors	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
Ribulose-phoshate binding barrel	0	DIRECT
Cyclophilin-like	0	DIRECT
RCC1/BLIP-II	0	DIRECT
SH3-domain	0	DIRECT
EF-G C-terminal domain-like	0	DIRECT
Rudiment single hybrid motif	0	DIRECT
Restriction endonuclease-like	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
Glutamine synthetase/guanido kinase	0	DIRECT
Myosin rod fragments	0	DIRECT
Cation efflux protein transmembrane domain-like	0	DIRECT
SGNH hydrolase	0	DIRECT
Mitochondrial cytochrome c oxidase subunit VIc	0	DIRECT
Acyl-CoA dehydrogenase NM domain-like	0	DIRECT
Periplasmic binding protein-like I	0	DIRECT
6-phosphogluconate dehydrogenase C-terminal domain-like	0	DIRECT
TGS-like	0	DIRECT
Sm-like ribonucleoproteins	0	DIRECT
SNARE fusion complex	0	DIRECT
Transcription factor IIA (TFIIA), alpha-helical domain	0	DIRECT
Sec7 domain	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
GAS2 domain-like	0	DIRECT
cAMP-binding domain-like	0	DIRECT
HAD-like	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
The spindle assembly checkpoint protein mad2	0	DIRECT
Tubulin nucleotide-binding domain-like	0	DIRECT
HRDC-like	0	DIRECT
Pectin lyase-like	0	DIRECT
HD-domain/PDEase-like	0	DIRECT
Bet v1-like	0	DIRECT
Carboxypeptidase regulatory domain-like	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
Formin homology 2 domain (FH2 domain)	0	DIRECT
L30e-like	0	DIRECT
Cysteine-rich domain	0	DIRECT
EGF/Laminin	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	0	DIRECT
Integrin domains	0	DIRECT
Nucleotide-binding domain	0	DIRECT
Actin-like ATPase domain	0	DIRECT
Rhodanese/Cell cycle control phosphatase	0	DIRECT
Single hybrid motif	0	DIRECT
PEP carboxykinase-like	0	DIRECT
UBA-like	0	DIRECT
Nucleotide cyclase	0	DIRECT
Phospholipase D/nuclease	0	DIRECT
CRAL/TRIO domain	0	DIRECT
SCP-like	0	DIRECT
Thiolase-like	0	DIRECT
S-adenosyl-L-methionine-dependent methyltransferases	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
PRTase-like	0	DIRECT
Hemopexin-like domain	0	DIRECT
PHM/PNGase F	0	DIRECT
YbiA-like	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Tricorn protease domain 2	0	DIRECT
NAD kinase/diacylglycerol kinase-like	0	DIRECT
Ribosomal protein S10	0	DIRECT
PAP/OAS1 substrate-binding domain	0	DIRECT
R3H domain	0	DIRECT
PP2C-like	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Alkaline phosphatase-like	0	DIRECT
ARM repeat	0.0775	INHERITED FROM: brood size variant || epithelial system physiology variant || germ cell physiology variant
RNA-binding domain, RBD	0.2109	INHERITED FROM: brood size variant || sterile F1
PapD-like	0.2415	INHERITED FROM: sterile progeny
Nicotinic receptor ligand binding domain-like	0.2685	INHERITED FROM: synaptic transmission variant || nervous system physiology variant || coelomic system physiology variant || coelomocyte endocytosis defective || coelomocyte physiology variant
Voltage-gated potassium channels	0.3168	INHERITED FROM: muscle cell activity variant
Neurotransmitter-gated ion-channel transmembrane pore	0.3217	INHERITED FROM: synaptic transmission variant || nervous system physiology variant || coelomic system physiology variant || coelomocyte endocytosis defective || coelomocyte physiology variant
Ubiquitin-like	0.3619	INHERITED FROM: muscle system physiology variant || body muscle dystrophy || muscle cell physiology variant
Metallo-dependent phosphatases	0.4289	INHERITED FROM: radiation induced germ cell apoptosis variant || germ cell resistant ionizing radiation
FYVE/PHD zinc finger	0.525	INHERITED FROM: transgenerational loss of fertility || coelomic system physiology variant || coelomocyte endocytosis defective || coelomocyte physiology variant
EF-hand	0.6168	INHERITED FROM: muscle system physiology variant || somatic sheath physiology variant || muscle cell physiology variant || gonad sheath contractions variant || somatic gonad physiology variant
WD40 repeat-like	0.6556	INHERITED FROM: reduced brood size || brood size variant || germ cell physiology variant
TPR-like	0.6803	INHERITED FROM: male gonad development variant
GTPase activation domain, GAP	0.7352	INHERITED FROM: muscle system physiology variant || muscle cell attachment variant
Saposin	0.7867	INHERITED FROM: radiation induced germ cell apoptosis variant || germ cell resistant ionizing radiation || germ cell ionizing radiation response variant
(Phosphotyrosine protein) phosphatases II	0.8143	INHERITED FROM: muscle cell attachment variant
P-loop containing nucleoside triphosphate hydrolases	0.844	INHERITED FROM: brood size variant || postsynaptic region physiology variant || germ cell physiology variant || nervous system physiology variant || male gonad development variant
"Winged helix" DNA-binding domain	0.8854	INHERITED FROM: germline mortal || body muscle dystrophy || male gonad development variant || muscle dystrophy
RING/U-box	0.9058	INHERITED FROM: germ cell hypersensitive ionizing radiation || germ cell ionizing radiation response variant
Lamin A/C globular tail domain	0.9466	INHERITED FROM: muscle system physiology variant
PLP-dependent transferases	0.9522	INHERITED FROM: radiation induced germ cell apoptosis variant || germ cell resistant ionizing radiation
SH2 domain	1	INHERITED FROM: muscle system physiology variant || muscle cell attachment variant || muscle cell physiology variant
Protein kinase-like (PK-like)	1	INHERITED FROM: muscle system physiology variant || body muscle dystrophy || muscle cell physiology variant || neuron physiology variant

Family domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Hect, E3 ligase catalytic domain	0	DIRECT
Chitinase insertion domain	0	DIRECT
Kix domain of CBP (creb binding protein)	0	DIRECT
Mob1/phocein	0	DIRECT
Alcohol dehydrogenase-like, C-terminal domain	0	DIRECT
Pyk2-associated protein beta ARF-GAP domain	0	DIRECT
Tudor domain	0	DIRECT
GAPDH-like	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Ras-binding domain, RBD	0	DIRECT
Myeloperoxidase-like	0	DIRECT
POU-specific domain	0	DIRECT
Aldo-keto reductases (NADP)	0	DIRECT
Matrix metalloproteases, catalytic domain	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
PDI-like	0	DIRECT
D-aminoacid oxidase-like	0	DIRECT
Thiolase-related	0	DIRECT
Ephrin ectodomain	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
Amylase, catalytic domain	0	DIRECT
CAT-like	0	DIRECT
Autophagin-like	0	DIRECT
Reductases	0	DIRECT
2Fe-2S ferredoxin domains from multidomain proteins	0	DIRECT
Growth factor receptor domain	0	DIRECT
PABC (PABP) domain	0	DIRECT
Myosin rod fragments	0	DIRECT
Prefoldin	0	DIRECT
RNA editing terminal uridyl transferase 2, RET2, domain 2	0	DIRECT
alpha-mannosidase	0	DIRECT
Adenylyl and guanylyl cyclase catalytic domain	0	DIRECT
beta-glycanases	0	DIRECT
BAR domain	0	DIRECT
Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
Ubiquitin activating enzymes (UBA)	0	DIRECT
MIR domain	0	DIRECT
H-NOX domain	0	DIRECT
Neurolysin-like	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Ribosomal protein L1	0	DIRECT
DNA replication initiator (cdc21/cdc54) N-terminal domain	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
Dual specificity phosphatase-like	0	DIRECT
Cap-Gly domain	0	DIRECT
CRAL/TRIO domain	0	DIRECT
Purple acid phosphatase-like	0	DIRECT
Arylamine N-methyltransferase	0	DIRECT
SAP domain	0	DIRECT
Integrin A (or I) domain	0	DIRECT
FCH domain	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Patatin	0	DIRECT
DPP6 catalytic domain-like	0	DIRECT
FAD/NAD-linked reductases, N-terminal and central domains	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
Cell cycle control phosphatase, catalytic domain	0	DIRECT
Nop domain	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
Deoxycytidylate deaminase-like	0	DIRECT
Internalin LRR domain	0	DIRECT
Bacterial dinuclear zinc exopeptidases	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
Class I glutamine amidotransferases (GAT)	0	DIRECT
Cyclophilin (peptidylprolyl isomerase)	0	DIRECT
Pseudouridine synthase I TruA	0	DIRECT
Phosphotyrosine-binding domain (PTB)	0	DIRECT
GHMP Kinase, N-terminal domain	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
Meta-cation ATPase, catalytic domain P	0	DIRECT
Calcium ATPase, transmembrane domain M	0	DIRECT
PEP carboxykinase C-terminal domain	0	DIRECT
L-arabinose binding protein-like	0	DIRECT
alpha-Amylases, C-terminal beta-sheet domain	0	DIRECT
Sir2 family of transcriptional regulators	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
Laminin-type module	0	DIRECT
UBC-related	0	DIRECT
Crotonase-like	0	DIRECT
Calcium ATPase, transduction domain A	0	DIRECT
Biotinyl/lipoyl-carrier proteins and domains	0	DIRECT
La domain	0	DIRECT
t-snare proteins	0	DIRECT
Pancreatic carboxypeptidase, activation domain	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
NADPH-cytochrome p450 reductase FAD-binding domain-like	0	DIRECT
Inositol polyphosphate 5-phosphatase (IPP5)	0	DIRECT
TAZ domain	0	DIRECT
F-box domain	0	DIRECT
CBS-domain pair	0	DIRECT
Type II chitinase	0	DIRECT
Annexin	0	DIRECT
T-box	0	DIRECT
Brix domain	0	DIRECT
Glycerol-3-phosphate transporter	0	DIRECT
Anticodon-binding domain	0	DIRECT
SNARE fusion complex	0	DIRECT
Citrate synthase	0	DIRECT
Guanido kinase catalytic domain	0	DIRECT
WW domain	0	DIRECT
Transforming growth factor (TGF)-beta	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
Cytoplasmic domain of inward rectifier potassium channel	0	DIRECT
CCCH zinc finger	0	DIRECT
Intermediate filament protein, coiled coil region	0	DIRECT
Heme-dependent catalases	0	DIRECT
Lipovitellin-phosvitin complex, superhelical domain	0	DIRECT
Tim10/DDP	0	DIRECT
PX domain	0	DIRECT
Pepsin-like	0	DIRECT
Calpain large subunit, middle domain (domain III)	0	DIRECT
Pumilio repeat	0	DIRECT
Third domain of FERM	0	DIRECT
Transcription factor IIA (TFIIA), beta-barrel domain	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
Hydantoinase (dihydropyrimidinase)	0	DIRECT
RhoGDI-like	0	DIRECT
Ypt/Rab-GAP domain of gyp1p	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
Spectrin repeat	0	DIRECT
Choline/Carnitine O-acyltransferase	0	DIRECT
WGR domain	0	DIRECT
Hydantoinase (dihydropyrimidinase), catalytic domain	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
SWIRM domain	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
PLC-like (P variant)	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
GABA-aminotransferase-like	0	DIRECT
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain	0	DIRECT
Calmodulin-like	0	DIRECT
First domain of FERM	0	DIRECT
Sm motif of small nuclear ribonucleoproteins, SNRNP	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
FF domain	0	DIRECT
Ribokinase-like	0	DIRECT
Purple acid phosphatase, N-terminal domain	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
CUT domain	0	DIRECT
Ribosomal protein S10	0	DIRECT
FabD-like	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
Phosphoribosyltransferases (PRTases)	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
PR-1-like	0	DIRECT
Carbonic anhydrase	0	DIRECT
ATP-dependent protease Lon (La), catalytic domain	0	DIRECT
Acylamino-acid-releasing enzyme, C-terminal donain	0	DIRECT
Fungal lipases	0	DIRECT
SMAD domain	0	DIRECT
Hsp90 middle domain	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Lesion bypass DNA polymerase (Y-family), catalytic domain	0	DIRECT
Cytochrome b5	0	DIRECT
Fatty acid binding protein-like	0	DIRECT
Astacin	0	DIRECT
ARID domain	0	DIRECT
Tubulin, GTPase domain	0	DIRECT
Polo-box duplicated region	0	DIRECT
Ferredoxin domains from multidomain proteins	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase Pyr module	0	DIRECT
TBP-associated factors, TAFs	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Inositol monophosphatase/fructose-1,6-bisphosphatase-like	0	DIRECT
WWE domain	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
Small-conductance potassium channel	0	DIRECT
Ribosomal protein L18 and S11	0	DIRECT
BC C-terminal domain-like	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
Lipovitellin-phosvitin complex; beta-sheet shell regions	0	DIRECT
Rv2717c-like	0	DIRECT
NADPH-cytochrome p450 reductase-like	0	DIRECT
Ras GEF	0	DIRECT
28-residue LRR	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
YWTD domain	0	DIRECT
Second domain of FERM	0	DIRECT
Chaperone J-domain	0	DIRECT
Ferredoxin reductase FAD-binding domain-like	0	DIRECT
Carboxylesterase	0	DIRECT
Kinase associated domain 1, KA1	0	DIRECT
L30e/L7ae ribosomal proteins	0	DIRECT
XPF/Rad1/Mus81 nuclease	0	DIRECT
Smc hinge domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Sec63 N-terminal domain	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
Lactate & malate dehydrogenases, C-terminal domain	0	DIRECT
ALDH-like	0	DIRECT
Carboxypeptidase regulatory domain	0	DIRECT
Metal cation-transporting ATPase, ATP-binding domain N	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
Translation initiation factor eIF4e	0	DIRECT
Acyl-carrier protein (ACP)	0	DIRECT
Group II chaperonin (CCT, TRIC), apical domain	0	DIRECT
Cofilin-like	0	DIRECT
Myotubularin-like phosphatases	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
Sema domain	0	DIRECT
RUN domain	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
Ribonuclease H	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
COMT-like	0	DIRECT
Hexokinase	0	DIRECT
E2F dimerization segment	0	DIRECT
EGF-type module	0	DIRECT
Ganglioside M2 (gm2) activator	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
Poly(A) polymerase, PAP, middle domain	0	DIRECT
Bromodomain	0	DIRECT
SPRY domain	0	DIRECT
HSP20	0	DIRECT
Bacterial lipase	0	DIRECT
Proprotein convertase P-domain	0	DIRECT
PUA domain	0	DIRECT
U-box	0	DIRECT
Band 7/SPFH domain	0	DIRECT
RIO1-like kinases	0	DIRECT
Tetraspanin	0	DIRECT
Subtilases	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
Diap1 N-terninal region-like	0	DIRECT
Phoshoinositide 3-kinase (PI3K), catalytic domain	0	DIRECT
Doublecortin (DC)	0	DIRECT
Adenosine/AMP deaminase	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
MutT-like	0	DIRECT
Methionine aminopeptidase, insert domain	0	DIRECT
Vertebrate phospholipase A2	0	DIRECT
Clathrin adaptor core protein	0	DIRECT
acyl-CoA oxidase C-terminal domains	0	DIRECT
Rap/Ran-GAP	0	DIRECT
Small Kunitz-type inhibitors & BPTI-like toxins	0	DIRECT
GAS2 domain	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain	0	DIRECT
Clc chloride channel	0	DIRECT
Glycogenin	0	DIRECT
D-aminoacid oxidase, N-terminal domain	0	DIRECT
Serpins	0	DIRECT
Smr domain	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	0	DIRECT
Reprolysin-like	0	DIRECT
NOL1/NOP2/sun	0	DIRECT
Cation efflux protein transmembrane domain-like	0	DIRECT
RNA-polymerase beta	0	DIRECT
Protein prenyltransferases	0	DIRECT
L domain	0	DIRECT
14-3-3 protein	0	DIRECT
Polypeptide N-acetylgalactosaminyltransferase 1, N-terminal domain	0	DIRECT
beta-Lactamase/D-ala carboxypeptidase	0	DIRECT
Eps15 homology domain (EH domain)	0	DIRECT
STAR domain	0	DIRECT
ABC transporter transmembrane region	0	DIRECT
Purine and uridine phosphorylases	0	DIRECT
p120GAP domain-like	0	DIRECT
Phoshatidylinositol transfer protein, PITP	0	DIRECT
6-phosphogluconate dehydrogenase-like, N-terminal domain	0	DIRECT
Biotin dependent carboxylase carboxyltransferase domain	0	DIRECT
Calpain large subunit, catalytic domain (domain II)	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
Ngr ectodomain-like	0	DIRECT
Globins	0	DIRECT
Formin homology 2 domain (FH2 domain)	0	DIRECT
Armadillo repeat	0	DIRECT
Proteasome subunits	0	DIRECT
GYF domain	0	DIRECT
Aminomethyltransferase beta-barrel domain	0	DIRECT
N-acetyl transferase, NAT	0	DIRECT
Epoxide hydrolase	0	DIRECT
Acireductone dioxygenase	0	DIRECT
PhzC/PhzF-like	0	DIRECT
LysM domain	0	DIRECT
Ricin B-like	0	DIRECT
Alcohol dehydrogenase-like, N-terminal domain	0	DIRECT
Class I alpha-1;2-mannosidase, catalytic domain	0	DIRECT
Osmotin, thaumatin-like protein	0	DIRECT
Cadherin	0	DIRECT
Single strand DNA-binding domain, SSB	0	DIRECT
CalX-beta domain	0	DIRECT
MFPT repeat	0	DIRECT
Sec7 domain	0	DIRECT
PDZ domain	0	DIRECT
RING finger domain, C3HC4	0	DIRECT
Acyl-CoA thioesterase	0	DIRECT
PhyH-like	0	DIRECT
Linker histone H1/H5	0	DIRECT
Kelch motif	0	DIRECT
Nucleotide and nucleoside kinases	0	DIRECT
Pancreatic carboxypeptidases	0	DIRECT
Phoshoinositide 3-kinase (PI3K) helical domain	0	DIRECT
Histone deacetylase, HDAC	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
Serine carboxypeptidase-like	0	DIRECT
N-acetylglucosaminyltransferase I	0	DIRECT
Clathrin coat assembly domain	0	DIRECT
Erythroid transcription factor GATA-1	0	DIRECT
Nitrogenase iron protein-like	0	DIRECT
MIT domain	0	DIRECT
Mammalian PLC	0	DIRECT
Ammonium transporter	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
Paired domain	0	DIRECT
Cytidylyltransferase	0	DIRECT
Chromo domain	0	DIRECT
Poly(ADP-ribose) polymerase, C-terminal domain	0	DIRECT
BTB/POZ domain	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
HEAT repeat	0	DIRECT
ATI-like	0	DIRECT
Laminin G-like module	0	DIRECT
LEM domain	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
DEP domain	0	DIRECT
acyl-CoA oxidase N-terminal domains	0	DIRECT
AraD-like aldolase/epimerase	0	DIRECT
B-box zinc-binding domain	0	DIRECT
L-aminoacid/polyamine oxidase	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
Regulator of chromosome condensation RCC1	0	DIRECT
cAMP-binding domain	0	DIRECT
eIF1-like	0	DIRECT
NTF2-like	0	DIRECT
BolA-like	0	DIRECT
AlkB-like	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	0	DIRECT
CoA transferase alpha subunit-like	0	DIRECT
Histone lysine methyltransferases	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
FYVE, a phosphatidylinositol-3-phosphate binding domain	0	DIRECT
1,3-glucuronyltransferase	0	DIRECT
RNA-polymerase beta-prime	0	DIRECT
Frizzled cysteine-rich domain	0	DIRECT
LacY-like proton/sugar symporter	0	DIRECT
DEATH domain, DD	0	DIRECT
YicI catalytic domain-like	0	DIRECT
Actin/HSP70	0	DIRECT
Trunk domain of Sec23/24	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
Troponin I	0	DIRECT
Adenain-like	0	DIRECT
Inositol polyphosphate kinase (IPK)	0	DIRECT
Dimeric isocitrate & isopropylmalate dehydrogenases	0	DIRECT
Phosphatidylethanolamine binding protein	0	DIRECT
Papain-like	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain	0	DIRECT
CO dehydrogenase flavoprotein N-terminal domain-like	0	DIRECT
Tropomyosin	0	DIRECT
SMAD MH1 domain	0	DIRECT
BC ATP-binding domain-like	0	DIRECT
LDL receptor-like module	0	DIRECT
Mitochondrial carrier	0	DIRECT
IF2B-like	0	DIRECT
Cell cycle transcription factor e2f-dp	0	DIRECT
Sec63 C-terminal domain-like	0	DIRECT
Transcriptional factor domain	0	DIRECT
Galectin (animal S-lectin)	0	DIRECT
MIF-related	0	DIRECT
N-type ATP pyrophosphatases	0	DIRECT
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)	0	DIRECT
Class I aldolase	0	DIRECT
Hermes transposase-like	0	DIRECT
Gastric lipase	0	DIRECT
VHS domain	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
Roadblock/LC7 domain	0	DIRECT
Tetramerization domain of potassium channels	0	DIRECT
Trehalase-like	0	DIRECT
Gelsolin-like	0	DIRECT
Serum paraoxonase/arylesterase 1, PON1	0	DIRECT
AMPK-beta glycogen binding domain-like	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
Formate/glycerate dehydrogenases, NAD-domain	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Group II chaperonin (CCT, TRIC), ATPase domain	0	DIRECT
Class II glutamine amidotransferases	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase PP module	0	DIRECT
Ubiquitin-related	0	DIRECT
HAT/Suf repeat	0	DIRECT
Ribonuclease PH domain 1-like	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
FtsH protease domain-like	0	DIRECT
Hemocyanin middle domain	0	DIRECT
Elongation factors	0	DIRECT
beta-CASP RNA-metabolising hydrolases	0	DIRECT
Pyridoxal-dependent decarboxylase	0	DIRECT
NLI interacting factor-like phosphatase	0	DIRECT
Classic zinc finger, C2H2	0	DIRECT
YbiA-like	0	DIRECT
Phosphate binding protein-like	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
Zf-UBP	0	DIRECT
MIF4G domain-like	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
Translational machinery components	0	DIRECT
Integrin domains	0	DIRECT
LDH N-terminal domain-like	0	DIRECT
BEACH domain	0	DIRECT
LIM domain	0	DIRECT
Calponin-homology domain, CH-domain	0	DIRECT
Sterol carrier protein, SCP	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
HCDH C-domain-like	0	DIRECT
Aquaporin-like	0	DIRECT
SH3-domain	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
PDEase	0	DIRECT
Peptidylglycine alpha-hydroxylating monooxygenase, PHM	0	DIRECT
Cystathionine synthase-like	0	DIRECT
Choline kinase	0	DIRECT
Elafin-like	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
ets domain	0	DIRECT
Glycerol kinase	0	DIRECT
PP2C-like	0	DIRECT
Fibronectin type III	0	DIRECT
Glutamine synthetase catalytic domain	0	DIRECT
Glutaminase	0	DIRECT
Bactericidal permeability-increasing protein, BPI	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Rhomboid-like	0	DIRECT
Neurotransmitter-gated ion-channel transmembrane pore	0	DIRECT
Complement control module/SCR domain	0	DIRECT
Oxysterol-binding protein	0	DIRECT
Hedgehog C-terminal (Hog) autoprocessing domain	0	DIRECT
Arylsulfatase	0	DIRECT
BSD domain	0	DIRECT
Aminoacid dehydrogenase-like, C-terminal domain	0	DIRECT
YihX-like	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
Hemopexin-like domain	0	DIRECT
5' to 3' exonuclease catalytic domain	0	DIRECT
Transcription factor IIA (TFIIA), alpha-helical domain	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
HMG-box	0	DIRECT
Eukaryotic type KH-domain (KH-domain type I)	0	DIRECT
Cold shock DNA-binding domain-like	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
Synaptotagmin-like (S variant)	0	DIRECT
Multidomain sulfurtransferase (rhodanese)	0	DIRECT
BC N-terminal domain-like	0	DIRECT
EF-hand modules in multidomain proteins	0	DIRECT
Glycerophosphoryl diester phosphodiesterase	0	DIRECT
Tubulin, C-terminal domain	0	DIRECT
SAM (sterile alpha motif) domain	0	DIRECT
alpha-mannosidase, domain 2	0	DIRECT
Histidine acid phosphatase	0	DIRECT
AN1-like Zinc finger	0	DIRECT
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta	0	DIRECT
Family 19 glycosidase	0	DIRECT
UBX domain	0	DIRECT
RecA protein-like (ATPase-domain)	0	DIRECT
Gamma-glutamyltranspeptidase-like	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
CoA-binding domain	0	DIRECT
UBA domain	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
UDP-glucose pyrophosphorylase	0	DIRECT
Ribosomal protein S18	0	DIRECT
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains	0	DIRECT
FHA domain	0	DIRECT
EF-G/eEF-2 domains III and V	0	DIRECT
RNA methyltransferase FtsJ	0	DIRECT
4HBT-like	0	DIRECT
Poly(A) polymerase, PAP, C-terminal domain	0	DIRECT
PaaI/YdiI-like	0	DIRECT
Cdc48 N-terminal domain-like	0	DIRECT
Mo25 protein	0	DIRECT
Catalytic, N-terminal domain of histone methyltransferase Dot1l	0	DIRECT
Filamin repeat (rod domain)	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
Myb/SANT domain	0	DIRECT
Aminomethyltransferase folate-binding domain	0	DIRECT
HD domain	0	DIRECT
SAND domain	0	DIRECT
FAD-linked reductases, N-terminal domain	0	DIRECT
I set domains	0	DIRECT
Hormone receptor domain	0	DIRECT
Leukotriene A4 hydrolase catalytic domain	0	DIRECT
TatD Mg-dependent DNase-like	0	DIRECT
NHL repeat	0	DIRECT
UDPGT-like	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
Pleckstrin-homology domain (PH domain)	0	DIRECT
beta 1,4 galactosyltransferase (b4GalT1)	0	DIRECT
Plexin repeat	0	DIRECT
alpha-catenin/vinculin	0	DIRECT
Anticodon-binding domain of Class II aaRS	0	DIRECT
alpha-mannosidase, C-terminal domain	0	DIRECT
ZZ domain	0	DIRECT
Caspase catalytic domain	0	DIRECT
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
Poly(A) polymerase, PAP, N-terminal domain	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Spermadhesin, CUB domain	0	DIRECT
NagD-like	0	DIRECT
Arfaptin, Rac-binding fragment	0	DIRECT
Arginine methyltransferase	0	DIRECT
Canonical RBD	0.252	INHERITED FROM: brood size variant || sterile F1
Nicotinic receptor ligand binding domain-like	0.2736	INHERITED FROM: synaptic transmission variant || nervous system physiology variant || acetylcholine synaptic transmission variant || coelomic system physiology variant || coelomocyte endocytosis defective || coelomocyte physiology variant
MSP-like	0.2736	INHERITED FROM: sterile progeny
Voltage-gated potassium channels	0.3166	INHERITED FROM: muscle cell activity variant
Tandem AAA-ATPase domain	0.3268	INHERITED FROM: male fertility variant || male fertility reduced || male sterile
G proteins	0.4	INHERITED FROM: synaptic transmission variant || postsynaptic region physiology variant || nervous system physiology variant
BCR-homology GTPase activation domain (BH-domain)	0.7875	INHERITED FROM: muscle system physiology variant || muscle cell attachment variant
WD40-repeat	0.8033	INHERITED FROM: reduced brood size || brood size variant
Cyclin	0.8353	INHERITED FROM: male gonad development variant
Protein kinases, catalytic subunit	0.8924	INHERITED FROM: muscle system physiology variant || body muscle dystrophy || muscle cell physiology variant || neuron physiology variant
Motor proteins	0.951	INHERITED FROM: nervous system physiology variant || neuron physiology variant || ciliated neuron physiology variant
Lamin A/C globular tail domain	0.951	INHERITED FROM: muscle system physiology variant
SH2 domain	1	INHERITED FROM: muscle system physiology variant || muscle cell attachment variant || muscle cell physiology variant
Class I aminoacyl-tRNA synthetases (RS), catalytic domain	1	INHERITED FROM: receptor mediated endocytosis defective