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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

• Disease Ontology (DO) Ontology (DO)
  DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
  
• Human Phenotype (HP) Ontology (HP)
  HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
  
• Mouse Phenotype (MP) Ontology (MP)
  MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
  
• Worm Phenotype (WP) Ontology (WP)
  WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
  
• Yeast Phenotype (YP) Ontology (YP)
  Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
  
• Fly Phenotype (FP) Ontology (FP)
  FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
  
• Fly Anatomy (FA) Ontology (FA)
  FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
  
• Zebrafish Anatomy (ZA) Ontology (ZA)
  ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
  
• Xenopus Anatomy (XA) Ontology (XA)
  XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
  
• Arabidopsis Plant Ontology (AP) Ontology (AP)
  As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
  
• Enzyme Commission (EC) Ontology (EC)
  Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
  
• DrugBank ATC (DB) Ontology (DB)
  In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
  
• UniProtKB KeyWords (KW) Ontology (KW)
  Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
  
• UniProtKB UniPathway (UP) Ontology (UP)
  UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
  

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
  

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
  

Superfamily domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Chaperone J-domain	0	DIRECT
GYF domain	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
Putative DNA-binding domain	0	DIRECT
PP2C-like	0	DIRECT
PUA domain-like	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
Troponin coil-coiled subunits	0	DIRECT
YbiA-like	0	DIRECT
Actin-like ATPase domain	0	DIRECT
Di-copper centre-containing domain	0	DIRECT
PLC-like phosphodiesterases	0	DIRECT
FAD/NAD(P)-binding domain	0	DIRECT
Complement control module/SCR domain	0	DIRECT
TRAF domain-like	0	DIRECT
Polo-box domain	0	DIRECT
ALDH-like	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Ribokinase-like	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
Phoshotransferase/anion transport protein	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Integrin alpha N-terminal domain	0	DIRECT
Tricorn protease domain 2	0	DIRECT
PLP-dependent transferases	0	DIRECT
Ankyrin repeat	0	DIRECT
Aldolase	0	DIRECT
Lysozyme-like	0	DIRECT
DHS-like NAD/FAD-binding domain	0	DIRECT
Sec63 N-terminal domain-like	0	DIRECT
Nucleic acid-binding proteins	0	DIRECT
Periplasmic binding protein-like I	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
CBS-domain pair	0	DIRECT
cAMP-binding domain-like	0	DIRECT
Translation proteins	0	DIRECT
Heme-dependent peroxidases	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
Plexin repeat	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
Invertebrate chitin-binding proteins	0	DIRECT
Actin depolymerizing proteins	0	DIRECT
Glycosyl hydrolase domain	0	DIRECT
Metallo-hydrolase/oxidoreductase	0	DIRECT
Nucleotide cyclase	0	DIRECT
Pentein	0	DIRECT
NHL repeat	0	DIRECT
Rap/Ran-GAP	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
Spermadhesin, CUB domain	0	DIRECT
Serpins	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
L domain-like	0	DIRECT
KA1-like	0	DIRECT
Calcium ATPase, transmembrane domain M	0	DIRECT
GroEL apical domain-like	0	DIRECT
Transcription factor IIA (TFIIA), beta-barrel domain	0	DIRECT
E2F-DP heterodimerization region	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
Chitinase insertion domain	0	DIRECT
Hairpin loop containing domain-like	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
CAD & PB1 domains	0	DIRECT
Subtilisin-like	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
BAR/IMD domain-like	0	DIRECT
Class I glutamine amidotransferase-like	0	DIRECT
Zinc beta-ribbon	0	DIRECT
PX domain	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
Cystine-knot cytokines	0	DIRECT
LEM domain	0	DIRECT
Acid proteases	0	DIRECT
eIF1-like	0	DIRECT
MIT domain	0	DIRECT
RNI-like	0	DIRECT
L30e-like	0	DIRECT
Ypt/Rab-GAP domain of gyp1p	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
Thiolase-like	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
Lipovitellin-phosvitin complex, superhelical domain	0	DIRECT
Cupredoxins	0	DIRECT
Phospholipase A2, PLA2	0	DIRECT
TGS-like	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
Doublecortin (DC)	0	DIRECT
Ricin B-like lectins	0	DIRECT
Spectrin repeat	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0	DIRECT
Rhomboid-like	0	DIRECT
WGR domain-like	0	DIRECT
Adenine nucleotide alpha hydrolases-like	0	DIRECT
GroEL equatorial domain-like	0	DIRECT
Acid phosphatase/Vanadium-dependent haloperoxidase	0	DIRECT
Bet v1-like	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
Glycerol-3-phosphate (1)-acyltransferase	0	DIRECT
Sm-like ribonucleoproteins	0	DIRECT
SpoIIaa-like	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
ACP-like	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
HIT-like	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
Cytochrome b5-like heme/steroid binding domain	0	DIRECT
Heme-dependent catalase-like	0	DIRECT
Glycoside hydrolase/deacetylase	0	DIRECT
BolA-like	0	DIRECT
PAP/OAS1 substrate-binding domain	0	DIRECT
Fibronectin type III	0	DIRECT
PEP carboxykinase-like	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
HIT/MYND zinc finger-like	0	DIRECT
PK beta-barrel domain-like	0	DIRECT
HAD-like	0	DIRECT
Smc hinge domain	0	DIRECT
p53-like transcription factors	0	DIRECT
Tetraspanin	0	DIRECT
4Fe-4S ferredoxins	0	DIRECT
Ganglioside M2 (gm2) activator	0	DIRECT
Tudor/PWWP/MBT	0	DIRECT
PLP-binding barrel	0	DIRECT
Creatinase/prolidase N-terminal domain	0	DIRECT
SAP domain	0	DIRECT
Molybdenum cofactor biosynthesis proteins	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
LDH C-terminal domain-like	0	DIRECT
FabD/lysophospholipase-like	0	DIRECT
Lipovitellin-phosvitin complex; beta-sheet shell regions	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
BEACH domain	0	DIRECT
Small-conductance potassium channel	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
Carbon-nitrogen hydrolase	0	DIRECT
Tubulin C-terminal domain-like	0	DIRECT
ThrRS/AlaRS common domain	0	DIRECT
Nop domain	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
Clathrin adaptor appendage domain	0	DIRECT
S-adenosyl-L-methionine-dependent methyltransferases	0	DIRECT
Hedgehog/intein (Hint) domain	0	DIRECT
UBC-like	0	DIRECT
Galactose mutarotase-like	0	DIRECT
Metallo-dependent phosphatases	0	DIRECT
FAD-linked reductases, C-terminal domain	0	DIRECT
LysM domain	0	DIRECT
CoA-dependent acyltransferases	0	DIRECT
ArfGap/RecO-like zinc finger	0	DIRECT
B-box zinc-binding domain	0	DIRECT
Tubby C-terminal domain-like	0	DIRECT
Eukaryotic type KH-domain (KH-domain type I)	0	DIRECT
SH3-domain	0	DIRECT
Translational machinery components	0	DIRECT
SH2 domain	0	DIRECT
R3H domain	0	DIRECT
Phosphoglycerate mutase-like	0	DIRECT
Mitochondrial cytochrome c oxidase subunit VIc	0	DIRECT
Nucleotidyltransferase	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
NagB/RpiA/CoA transferase-like	0	DIRECT
Ferritin-like	0	DIRECT
Transcription factor IIA (TFIIA), alpha-helical domain	0	DIRECT
NAD kinase/diacylglycerol kinase-like	0	DIRECT
MgtE membrane domain-like	0	DIRECT
Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
Band 7/SPFH domain	0	DIRECT
RUN domain-like	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
Alkaline phosphatase-like	0	DIRECT
Intermediate filament protein, coiled coil region	0	DIRECT
2Fe-2S ferredoxin-like	0	DIRECT
Myosin rod fragments	0	DIRECT
UBA-like	0	DIRECT
Galactose oxidase, central domain	0	DIRECT
Cyclophilin-like	0	DIRECT
Tropomyosin	0	DIRECT
Subdomain of clathrin and coatomer appendage domain	0	DIRECT
BSD domain-like	0	DIRECT
SMR domain-like	0	DIRECT
HSP20-like chaperones	0	DIRECT
Families 57/38 glycoside transferase middle domain	0	DIRECT
Calponin-homology domain, CH-domain	0	DIRECT
Tim10-like	0	DIRECT
SET domain	0	DIRECT
Concanavalin A-like lectins/glucanases	0	DIRECT
CBD9-like	0	DIRECT
WW domain	0	DIRECT
PYP-like sensor domain (PAS domain)	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
RuvA domain 2-like	0	DIRECT
Mob1/phocein	0	DIRECT
Mss4-like	0	DIRECT
t-snare proteins	0	DIRECT
PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	DIRECT
GAS2 domain-like	0	DIRECT
Diaminopimelate epimerase-like	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
RCC1/BLIP-II	0	DIRECT
Metallo-dependent hydrolases	0	DIRECT
beta-lactamase/transpeptidase-like	0	DIRECT
Periplasmic binding protein-like II	0	DIRECT
Bromodomain	0	DIRECT
PABC (PABP) domain	0	DIRECT
DNA clamp	0	DIRECT
CalX-like	0	DIRECT
Rudiment single hybrid motif	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
TK C-terminal domain-like	0	DIRECT
Outer arm dynein light chain 1	0	DIRECT
SMAD/FHA domain	0	DIRECT
Carbohydrate phosphatase	0	DIRECT
Riboflavin synthase domain-like	0	DIRECT
FYVE/PHD zinc finger	0	DIRECT
SMAD MH1 domain	0	DIRECT
Immunoglobulin	0	DIRECT
Restriction endonuclease-like	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
Six-hairpin glycosidases	0	DIRECT
Kringle-like	0	DIRECT
Caspase-like	0	DIRECT
Arginase/deacetylase	0	DIRECT
HMG-box	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
Ammonium transporter	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
ARM repeat	0	DIRECT
GAT-like domain	0	DIRECT
MIR domain	0	DIRECT
TAZ domain	0	DIRECT
BPTI-like	0	DIRECT
Lipocalins	0	DIRECT
SAM/Pointed domain	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
Ferredoxin reductase-like, C-terminal NADP-linked domain	0	DIRECT
Sema domain	0	DIRECT
Folate-binding domain	0	DIRECT
SPOC domain-like	0	DIRECT
NAD(P)-linked oxidoreductase	0	DIRECT
SAND domain-like	0	DIRECT
AraD/HMP-PK domain-like	0	DIRECT
LuxS/MPP-like metallohydrolase	0	DIRECT
Thiamin diphosphate-binding fold (THDP-binding)	0	DIRECT
Nucleotide-binding domain	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
GroES-like	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Calcium ATPase, transduction domain A	0	DIRECT
Thioesterase/thiol ester dehydrase-isomerase	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
VPS9 domain	0	DIRECT
ClpP/crotonase	0	DIRECT
FtsH protease domain-like	0	DIRECT
Citrate synthase	0	DIRECT
RmlC-like cupins	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
Purine and uridine phosphorylases	0	DIRECT
Isocitrate/Isopropylmalate dehydrogenase-like	0	DIRECT
Prefoldin	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
HD-domain/PDEase-like	0	DIRECT
Ribosomal protein L1	0	DIRECT
Second domain of FERM	0	DIRECT
Apyrase	0	DIRECT
Serine protease inhibitors	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
Calpain large subunit, middle domain (domain III)	0	DIRECT
ADP-ribosylation	0	DIRECT
Annexin	0	DIRECT
Cytidine deaminase-like	0	DIRECT
Phospholipase D/nuclease	0	DIRECT
Calcium-dependent phosphotriesterase	0	DIRECT
SNARE fusion complex	0	DIRECT
Clavaminate synthase-like	0	DIRECT
Multidrug resistance efflux transporter EmrE	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
ARID-like	0	DIRECT
SNARE-like	0	DIRECT
Acyl-CoA N-acyltransferases (Nat)	0	DIRECT
TIMP-like	0	DIRECT
Actin-crosslinking proteins	0	DIRECT
alpha/beta-Hydrolases	0	DIRECT
Ribosomal protein S10	0	DIRECT
alpha-catenin/vinculin-like	0	DIRECT
Carboxypeptidase regulatory domain-like	0	DIRECT
Oxysterol-binding protein-like	0	DIRECT
Radical SAM enzymes	0	DIRECT
Osmotin, thaumatin-like protein	0	DIRECT
HCP-like	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
FF domain	0	DIRECT
EF-G C-terminal domain-like	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
Acyl-CoA dehydrogenase NM domain-like	0	DIRECT
lambda repressor-like DNA-binding domains	0	DIRECT
PDZ domain-like	0	DIRECT
3-carboxy-cis,cis-mucoante lactonizing enzyme	0	DIRECT
AN1-like Zinc finger	0	DIRECT
Terpenoid synthases	0	DIRECT
L-aspartase-like	0	DIRECT
Acyl-CoA dehydrogenase C-terminal domain-like	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
Nudix	0	DIRECT
Tubulin nucleotide-binding domain-like	0	DIRECT
Ras GEF	0	DIRECT
PRTase-like	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Integrin domains	0	DIRECT
Nucleotide-diphospho-sugar transferases	0	DIRECT
Kelch motif	0	DIRECT
Roadblock/LC7 domain	0	DIRECT
6-phosphogluconate dehydrogenase C-terminal domain-like	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
PIN domain-like	0	DIRECT
DEATH domain	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
dsRNA-binding domain-like	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
Tautomerase/MIF	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
Formate/glycerate dehydrogenase catalytic domain-like	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
Galactose-binding domain-like	0	DIRECT
ISP domain	0	DIRECT
PHM/PNGase F	0	DIRECT
ADC-like	0	DIRECT
PreATP-grasp domain	0	DIRECT
NTF2-like	0	DIRECT
WWE domain	0	DIRECT
FAD-binding/transporter-associated domain-like	0	DIRECT
Ribulose-phoshate binding barrel	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
GHMP Kinase, C-terminal domain	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
SGNH hydrolase	0	DIRECT
SAICAR synthase-like	0	DIRECT
Purple acid phosphatase, N-terminal domain	0	DIRECT
SNF-like	0	DIRECT
alpha/beta knot	0	DIRECT
Elafin-like	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
ABC transporter transmembrane region	0	DIRECT
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
Hect, E3 ligase catalytic domain	0	DIRECT
Aquaporin-like	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
Cysteine-rich domain	0	DIRECT
Kix domain of CBP (creb binding protein)	0	DIRECT
Single hybrid motif	0	DIRECT
Cytochrome c	0	DIRECT
alpha-helical ferredoxin	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
CCCH zinc finger	0	DIRECT
Alpha-L RNA-binding motif	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
Chromo domain-like	0	DIRECT
ENTH/VHS domain	0	DIRECT
Activating enzymes of the ubiquitin-like proteins	0	DIRECT
Flavoproteins	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
LexA/Signal peptidase	0	DIRECT
Protease propeptides/inhibitors	0	DIRECT
C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
Glutamine synthetase/guanido kinase	0	DIRECT
Cap-Gly domain	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
Cystatin/monellin	0	DIRECT
Cyclin-like	0	DIRECT
Translation proteins SH3-like domain	0	DIRECT
Cation efflux protein transmembrane domain-like	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
eIF4e-like	0	DIRECT
HRDC-like	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	0	DIRECT
PGBD-like	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
MFPT repeat-like	0	DIRECT
Terpenoid cyclases/Protein prenyltransferases	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
Cadherin-like	0	DIRECT
Bactericidal permeability-increasing protein, BPI	0	DIRECT
SCP-like	0	DIRECT
Hemopexin-like domain	0	DIRECT
Metal cation-transporting ATPase, ATP-binding domain N	0	DIRECT
Frizzled cysteine-rich domain	0	DIRECT
Formin homology 2 domain (FH2 domain)	0	DIRECT
Hormone receptor domain	0	DIRECT
DNase I-like	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
PEBP-like	0	DIRECT
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
DNA ligase/mRNA capping enzyme, catalytic domain	0	DIRECT
Rhodanese/Cell cycle control phosphatase	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Ribosomal proteins S24e, L23 and L15e	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
Aminomethyltransferase beta-barrel domain	0	DIRECT
BRCT domain	0	DIRECT
PH domain-like	0	DIRECT
Ribosomal protein S18	0	DIRECT
PAZ domain	0	DIRECT
Glutathione synthetase ATP-binding domain-like	0	DIRECT
FAD-linked oxidases, C-terminal domain	0	DIRECT
Clc chloride channel	0	DIRECT
Mitochondrial carrier	0	DIRECT
Nucleoporin domain	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
CRAL/TRIO domain	0	DIRECT
14-3-3 protein	0	DIRECT
Phosphoenolpyruvate/pyruvate domain	0	DIRECT
The spindle assembly checkpoint protein mad2	0	DIRECT
Pseudouridine synthase	0	DIRECT
Carbonic anhydrase	0	DIRECT
SIS domain	0	DIRECT
Composite domain of metallo-dependent hydrolases	0	DIRECT
PR-1-like	0	DIRECT
Metalloproteases ("zincins"), catalytic domain	0	DIRECT
Aminoacid dehydrogenase-like, N-terminal domain	0	DIRECT
Sec7 domain	0	DIRECT
Pectin lyase-like	0	DIRECT
Protein kinase-like (PK-like)	0.1486	INHERITED FROM: muscle system physiology variant || muscle dystrophy || body muscle dystrophy
RNA-binding domain, RBD	0.3438	INHERITED FROM: sterile F1 || brood size variant
Nicotinic receptor ligand binding domain-like	0.4166	INHERITED FROM: synaptic transmission variant || nervous system physiology variant
Neurotransmitter-gated ion-channel transmembrane pore	0.4707	INHERITED FROM: synaptic transmission variant || nervous system physiology variant
Ubiquitin-like	0.5116	INHERITED FROM: muscle system physiology variant || muscle dystrophy || body muscle dystrophy
PapD-like	0.7226	INHERITED FROM: sterile progeny
EF-hand	0.7907	INHERITED FROM: somatic gonad physiology variant || gonad sheath contractions variant || somatic sheath physiology variant
"Winged helix" DNA-binding domain	0.8042	INHERITED FROM: muscle system physiology variant || muscle dystrophy || body muscle dystrophy || brood size variant
EGF/Laminin	0.8489	INHERITED FROM: nervous system physiology variant
WD40 repeat-like	0.8574	INHERITED FROM: reduced brood size || brood size variant
P-loop containing nucleoside triphosphate hydrolases	0.867	INHERITED FROM: postsynaptic region physiology variant || nervous system physiology variant || brood size variant
Nucleotidylyl transferase	0.9997	INHERITED FROM: reduced brood size || brood size variant
LDL receptor-like module	1	INHERITED FROM: fertilization defective

Family domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
Cyclin	0	DIRECT
LIM domain	0	DIRECT
Cytochrome b5	0	DIRECT
Hsp90 middle domain	0	DIRECT
Sema domain	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
Clathrin adaptor core protein	0	DIRECT
2Fe-2S ferredoxin domains from multidomain proteins	0	DIRECT
FHA domain	0	DIRECT
XPF/Rad1/Mus81 nuclease	0	DIRECT
Glutamine synthetase catalytic domain	0	DIRECT
RING finger domain, C3HC4	0	DIRECT
beta-Lactamase/D-ala carboxypeptidase	0	DIRECT
Frizzled cysteine-rich domain	0	DIRECT
CoA-binding domain	0	DIRECT
NHL repeat	0	DIRECT
SNF-like	0	DIRECT
Class I aldolase	0	DIRECT
PP2C-like	0	DIRECT
BC C-terminal domain-like	0	DIRECT
alpha-catenin/vinculin	0	DIRECT
Ribosomal protein L1	0	DIRECT
Subtilases	0	DIRECT
Bacterial lipase	0	DIRECT
Lipovitellin-phosvitin complex; beta-sheet shell regions	0	DIRECT
Roadblock/LC7 domain	0	DIRECT
HMG-box	0	DIRECT
LEM domain	0	DIRECT
1,3-glucuronyltransferase	0	DIRECT
Synaptotagmin-like (S variant)	0	DIRECT
Second domain of FERM	0	DIRECT
Deoxycytidylate deaminase-like	0	DIRECT
Phosphatidylethanolamine binding protein	0	DIRECT
RNA-polymerase beta	0	DIRECT
Neurolysin-like	0	DIRECT
Calcium ATPase, transmembrane domain M	0	DIRECT
Transforming growth factor (TGF)-beta	0	DIRECT
Ribokinase-like	0	DIRECT
Complement control module/SCR domain	0	DIRECT
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
Kinase associated domain 1, KA1	0	DIRECT
Biotinyl/lipoyl-carrier proteins and domains	0	DIRECT
Glycerophosphoryl diester phosphodiesterase	0	DIRECT
Biotin dependent carboxylase carboxyltransferase domain	0	DIRECT
Lesion bypass DNA polymerase (Y-family), catalytic domain	0	DIRECT
eIF1-like	0	DIRECT
YbiA-like	0	DIRECT
Osmotin, thaumatin-like protein	0	DIRECT
Type II chitinase	0	DIRECT
Integrin A (or I) domain	0	DIRECT
Troponin I	0	DIRECT
DPP6 catalytic domain-like	0	DIRECT
alpha-mannosidase, domain 2	0	DIRECT
Fatty acid binding protein-like	0	DIRECT
Pepsin-like	0	DIRECT
Aminomethyltransferase beta-barrel domain	0	DIRECT
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains	0	DIRECT
Phosphoribosyltransferases (PRTases)	0	DIRECT
Myotubularin-like phosphatases	0	DIRECT
Erythroid transcription factor GATA-1	0	DIRECT
Mammalian PLC	0	DIRECT
ets domain	0	DIRECT
DEATH domain, DD	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
Poly(A) polymerase, PAP, C-terminal domain	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
AMPK-beta glycogen binding domain-like	0	DIRECT
Formate/glycerate dehydrogenases, NAD-domain	0	DIRECT
Myb/SANT domain	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
Aminoacid dehydrogenase-like, C-terminal domain	0	DIRECT
Lactate & malate dehydrogenases, C-terminal domain	0	DIRECT
PDEase	0	DIRECT
Adenosine/AMP deaminase	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain	0	DIRECT
Higher-molecular-weight phosphotyrosine protein phosphatases	0	DIRECT
BC ATP-binding domain-like	0	DIRECT
Hydantoinase (dihydropyrimidinase), catalytic domain	0	DIRECT
ALDH-like	0	DIRECT
Matrix metalloproteases, catalytic domain	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
IF2B-like	0	DIRECT
Ypt/Rab-GAP domain of gyp1p	0	DIRECT
Rv2717c-like	0	DIRECT
MPP-like	0	DIRECT
Phoshoinositide 3-kinase (PI3K), catalytic domain	0	DIRECT
Pyk2-associated protein beta ARF-GAP domain	0	DIRECT
Transcription factor IIA (TFIIA), alpha-helical domain	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
Ubiquitin activating enzymes (UBA)	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Hemopexin-like domain	0	DIRECT
Ubiquitin-related	0	DIRECT
RIO1-like kinases	0	DIRECT
SAND domain	0	DIRECT
NADPH-cytochrome p450 reductase FAD-binding domain-like	0	DIRECT
Rhomboid-like	0	DIRECT
PAZ domain	0	DIRECT
Arylamine N-methyltransferase	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
BTB/POZ domain	0	DIRECT
TAZ domain	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
Smr domain	0	DIRECT
Ribosomal protein S18	0	DIRECT
Galectin (animal S-lectin)	0	DIRECT
Calpain large subunit, catalytic domain (domain II)	0	DIRECT
Proprotein convertase P-domain	0	DIRECT
SH3-domain	0	DIRECT
Single strand DNA-binding domain, SSB	0	DIRECT
28-residue LRR	0	DIRECT
Crotonase-like	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	0	DIRECT
FtsH protease domain-like	0	DIRECT
Multidomain sulfurtransferase (rhodanese)	0	DIRECT
Histone deacetylase, HDAC	0	DIRECT
Methionine aminopeptidase, insert domain	0	DIRECT
Acetylcholinesterase-like	0	DIRECT
Calpain large subunit, middle domain (domain III)	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
Serpins	0	DIRECT
HAT/Suf repeat	0	DIRECT
AAT-like	0	DIRECT
Cytidylyltransferase	0	DIRECT
BAR domain	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	0	DIRECT
Tropomyosin	0	DIRECT
Sec63 N-terminal domain	0	DIRECT
Acireductone dioxygenase	0	DIRECT
Dual specificity phosphatase-like	0	DIRECT
Armadillo repeat	0	DIRECT
Reductases	0	DIRECT
ARID domain	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
GYF domain	0	DIRECT
Chaperone J-domain	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
STAR domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
Fungal lipases	0	DIRECT
Translational machinery components	0	DIRECT
Linker histone H1/H5	0	DIRECT
SH2 domain	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
Nucleotide and nucleoside kinases	0	DIRECT
CO dehydrogenase flavoprotein N-terminal domain-like	0	DIRECT
Poly(A) polymerase, PAP, N-terminal domain	0	DIRECT
Protein serine/threonine phosphatase	0	DIRECT
EF-G/eEF-2 domains III and V	0	DIRECT
Sir2 family of transcriptional regulators	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
BSD domain	0	DIRECT
Adenylyl and guanylyl cyclase catalytic domain	0	DIRECT
POU-specific domain	0	DIRECT
Zf-UBP	0	DIRECT
PhzC/PhzF-like	0	DIRECT
Chromo domain	0	DIRECT
Elongation factors	0	DIRECT
Sm motif of small nuclear ribonucleoproteins, SNRNP	0	DIRECT
BEACH domain	0	DIRECT
Diap1 N-terninal region-like	0	DIRECT
SAM (sterile alpha motif) domain	0	DIRECT
Inositol polyphosphate kinase (IPK)	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase PP module	0	DIRECT
NagD-like	0	DIRECT
E2F dimerization segment	0	DIRECT
Purple acid phosphatase, N-terminal domain	0	DIRECT
Pleckstrin-homology domain (PH domain)	0	DIRECT
Hydantoinase (dihydropyrimidinase)	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Leukotriene A4 hydrolase catalytic domain	0	DIRECT
PDZ domain	0	DIRECT
Pyridoxal-dependent decarboxylase	0	DIRECT
Actin/HSP70	0	DIRECT
Papain-like	0	DIRECT
RhoGDI-like	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
Acylamino-acid-releasing enzyme, C-terminal donain	0	DIRECT
4HBT-like	0	DIRECT
ABC transporter transmembrane region	0	DIRECT
D-aminoacid oxidase, N-terminal domain	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Group II chaperonin (CCT, TRIC), apical domain	0	DIRECT
FAD-linked reductases, N-terminal domain	0	DIRECT
FF domain	0	DIRECT
Filamin repeat (rod domain)	0	DIRECT
Sec7 domain	0	DIRECT
Purple acid phosphatase-like	0	DIRECT
Rap/Ran-GAP	0	DIRECT
Bactericidal permeability-increasing protein, BPI	0	DIRECT
cAMP-binding domain	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
Catalytic, N-terminal domain of histone methyltransferase Dot1l	0	DIRECT
Autophagin-like	0	DIRECT
AN1-like Zinc finger	0	DIRECT
Aldo-keto reductases (NADP)	0	DIRECT
Bromodomain	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
Gamma-glutamyltranspeptidase-like	0	DIRECT
Calmodulin-like	0	DIRECT
Carboxylesterase	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
Cap-Gly domain	0	DIRECT
Anticodon-binding domain of Class II aaRS	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Cytoplasmic domain of inward rectifier potassium channel	0	DIRECT
Caspase catalytic domain	0	DIRECT
WWE domain	0	DIRECT
Spermadhesin, CUB domain	0	DIRECT
Chitinase insertion domain	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
Laminin G-like module	0	DIRECT
Serum paraoxonase/arylesterase 1, PON1	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
I set domains	0	DIRECT
Mo25 protein	0	DIRECT
UDP-glucose pyrophosphorylase	0	DIRECT
Meta-cation ATPase, catalytic domain P	0	DIRECT
CAT-like	0	DIRECT
F-box domain	0	DIRECT
Transcription factor IIA (TFIIA), beta-barrel domain	0	DIRECT
Prefoldin	0	DIRECT
Small Kunitz-type inhibitors & BPTI-like toxins	0	DIRECT
Sec63 C-terminal domain-like	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
Tetraspanin	0	DIRECT
Astacin	0	DIRECT
6-phosphogluconate dehydrogenase-like, N-terminal domain	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Protein prenyltransferases	0	DIRECT
TBP-associated factors, TAFs	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Acyl-carrier protein (ACP)	0	DIRECT
beta 1,4 galactosyltransferase (b4GalT1)	0	DIRECT
UBA domain	0	DIRECT
MIR domain	0	DIRECT
NADPH-cytochrome p450 reductase-like	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
alpha-mannosidase, C-terminal domain	0	DIRECT
PhyH-like	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
Cold shock DNA-binding domain-like	0	DIRECT
Cdc48 N-terminal domain-like	0	DIRECT
Tudor domain	0	DIRECT
Neurotransmitter-gated ion-channel transmembrane pore	0	DIRECT
COMT-like	0	DIRECT
Hermes transposase-like	0	DIRECT
Hexokinase	0	DIRECT
GAS2 domain	0	DIRECT
Double-stranded RNA-binding domain (dsRBD)	0	DIRECT
TatD Mg-dependent DNase-like	0	DIRECT
Guanido kinase catalytic domain	0	DIRECT
Nitrogenase iron protein-like	0	DIRECT
Class I glutamine amidotransferases (GAT)	0	DIRECT
Amylase, catalytic domain	0	DIRECT
Elafin-like	0	DIRECT
Pumilio repeat	0	DIRECT
L-aminoacid/polyamine oxidase	0	DIRECT
H-NOX domain	0	DIRECT
CalX-beta domain	0	DIRECT
NTF2-like	0	DIRECT
Calponin-homology domain, CH-domain	0	DIRECT
Intermediate filament protein, coiled coil region	0	DIRECT
Extended PAW domain	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
T-box	0	DIRECT
HEAT repeat	0	DIRECT
PHD domain	0	DIRECT
Cofilin-like	0	DIRECT
SAP domain	0	DIRECT
Heme-dependent catalases	0	DIRECT
Tubulin, C-terminal domain	0	DIRECT
Tubulin, GTPase domain	0	DIRECT
Poly(A) polymerase, PAP, middle domain	0	DIRECT
Tetramerization domain of potassium channels	0	DIRECT
ZZ domain	0	DIRECT
SMAD MH1 domain	0	DIRECT
N-acetylglucosaminyltransferase I	0	DIRECT
Patatin	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
Anticodon-binding domain	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
Classic zinc finger, C2H2	0	DIRECT
VHS domain	0	DIRECT
CBS-domain pair	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Ricin B-like	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
Doublecortin (DC)	0	DIRECT
Laminin-type module	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Oxysterol-binding protein	0	DIRECT
SNARE fusion complex	0	DIRECT
PABC (PABP) domain	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
Trehalase-like	0	DIRECT
DEP domain	0	DIRECT
Phosphotyrosine-binding domain (PTB)	0	DIRECT
Carbonic anhydrase	0	DIRECT
Plexin repeat	0	DIRECT
Peptidylglycine alpha-hydroxylating monooxygenase, PHM	0	DIRECT
Sterol carrier protein, SCP	0	DIRECT
Arylsulfatase	0	DIRECT
Band 7/SPFH domain	0	DIRECT
Ribonucleotide reductase-like	0	DIRECT
YicI catalytic domain-like	0	DIRECT
RUN domain	0	DIRECT
Dimeric isocitrate & isopropylmalate dehydrogenases	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
Myeloperoxidase-like	0	DIRECT
Arfaptin, Rac-binding fragment	0	DIRECT
Histidine acid phosphatase	0	DIRECT
L domain	0	DIRECT
Ras GEF	0	DIRECT
Formin homology 2 domain (FH2 domain)	0	DIRECT
Alcohol dehydrogenase-like, C-terminal domain	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
Cation efflux protein transmembrane domain-like	0	DIRECT
PUA domain	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
Serine carboxypeptidase-like	0	DIRECT
LDH N-terminal domain-like	0	DIRECT
Lipovitellin-phosvitin complex, superhelical domain	0	DIRECT
t-snare proteins	0	DIRECT
Ferredoxin domains from multidomain proteins	0	DIRECT
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)	0	DIRECT
14-3-3 protein	0	DIRECT
DNA replication initiator (cdc21/cdc54) N-terminal domain	0	DIRECT
Kix domain of CBP (creb binding protein)	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
WGR domain	0	DIRECT
HCDH C-domain-like	0	DIRECT
Glycerol-3-phosphate transporter	0	DIRECT
L-arabinose binding protein-like	0	DIRECT
EF-hand modules in multidomain proteins	0	DIRECT
Citrate synthase	0	DIRECT
Fibronectin type III	0	DIRECT
L30e/L7ae ribosomal proteins	0	DIRECT
Regulator of chromosome condensation RCC1	0	DIRECT
HD domain	0	DIRECT
Purine and uridine phosphorylases	0	DIRECT
Group II chaperonin (CCT, TRIC), ATPase domain	0	DIRECT
Epoxide hydrolase	0	DIRECT
AraD-like aldolase/epimerase	0	DIRECT
PLC-like (P variant)	0	DIRECT
First domain of FERM	0	DIRECT
Ribonuclease PH domain 1-like	0	DIRECT
La domain	0	DIRECT
Ankyrin repeat	0	DIRECT
Tim10/DDP	0	DIRECT
Internalin LRR domain	0	DIRECT
Cadherin	0	DIRECT
Kelch motif	0	DIRECT
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta	0	DIRECT
Glutaminase	0	DIRECT
Apyrase	0	DIRECT
Trunk domain of Sec23/24	0	DIRECT
alpha-Amylases, C-terminal beta-sheet domain	0	DIRECT
LysM domain	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
5' to 3' exonuclease catalytic domain	0	DIRECT
LacY-like proton/sugar symporter	0	DIRECT
Glycerol kinase	0	DIRECT
alpha-mannosidase	0	DIRECT
FYVE, a phosphatidylinositol-3-phosphate binding domain	0	DIRECT
Myosin rod fragments	0	DIRECT
YihX-like	0	DIRECT
Translation initiation factor eIF4e	0	DIRECT
SPRY domain	0	DIRECT
Metal cation-transporting ATPase, ATP-binding domain N	0	DIRECT
RecA protein-like (ATPase-domain)	0	DIRECT
Pancreatic carboxypeptidase, activation domain	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase Pyr module	0	DIRECT
Mitochondrial carrier	0	DIRECT
Thiolase-related	0	DIRECT
Class I alpha-1;2-mannosidase, catalytic domain	0	DIRECT
Ganglioside M2 (gm2) activator	0	DIRECT
MFPT repeat	0	DIRECT
PaaI/YdiI-like	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
Pancreatic carboxypeptidases	0	DIRECT
UBX domain	0	DIRECT
Gelsolin-like	0	DIRECT
Nop domain	0	DIRECT
Glycogenin	0	DIRECT
U-box	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
Arginine methyltransferase	0	DIRECT
Hedgehog C-terminal (Hog) autoprocessing domain	0	DIRECT
Calcium ATPase, transduction domain A	0	DIRECT
Ras-binding domain, RBD	0	DIRECT
N-type ATP pyrophosphatases	0	DIRECT
SWIRM domain	0	DIRECT
Cell cycle control phosphatase, catalytic domain	0	DIRECT
MIF-related	0	DIRECT
Adenain-like	0	DIRECT
RNA editing terminal uridyl transferase 2, RET2, domain 2	0	DIRECT
Family 19 glycosidase	0	DIRECT
PR-1-like	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
B-box zinc-binding domain	0	DIRECT
Proteasome subunits	0	DIRECT
Phosphate binding protein-like	0	DIRECT
Gastric lipase	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
RNA-polymerase beta-prime	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
Inositol polyphosphate 5-phosphatase (IPP5)	0	DIRECT
Polo-box duplicated region	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
Eps15 homology domain (EH domain)	0	DIRECT
D-aminoacid oxidase-like	0	DIRECT
Smc hinge domain	0	DIRECT
Mob1/phocein	0	DIRECT
acyl-CoA oxidase C-terminal domains	0	DIRECT
BC N-terminal domain-like	0	DIRECT
Neutral endopeptidase (neprilysin)	0	DIRECT
Aminomethyltransferase folate-binding domain	0	DIRECT
MATH domain	0	DIRECT
RNA methyltransferase FtsJ	0	DIRECT
Aquaporin-like	0	DIRECT
Ammonium transporter	0	DIRECT
Cyclophilin (peptidylprolyl isomerase)	0	DIRECT
Ribosomal protein L18 and S11	0	DIRECT
GHMP Kinase, N-terminal domain	0	DIRECT
Acyl-CoA thioesterase	0	DIRECT
Integrin domains	0	DIRECT
Transcriptional factor domain	0	DIRECT
Inositol monophosphatase/fructose-1,6-bisphosphatase-like	0	DIRECT
AlkB-like	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
MIT domain	0	DIRECT
FCH domain	0	DIRECT
UBC-related	0	DIRECT
PDI-like	0	DIRECT
Cell cycle transcription factor e2f-dp	0	DIRECT
Clc chloride channel	0	DIRECT
Pseudouridine synthase I TruA	0	DIRECT
Hemocyanin middle domain	0	DIRECT
Ribosomal protein S10	0	DIRECT
Spectrin repeat	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain	0	DIRECT
Carboxypeptidase regulatory domain	0	DIRECT
CRAL/TRIO domain	0	DIRECT
PX domain	0	DIRECT
Alcohol dehydrogenase-like, N-terminal domain	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
ATP-dependent protease Lon (La), catalytic domain	0	DIRECT
BolA-like	0	DIRECT
Ngr ectodomain-like	0	DIRECT
Reprolysin-like	0	DIRECT
SMAD domain	0	DIRECT
HSP20	0	DIRECT
PEP carboxykinase C-terminal domain	0	DIRECT
Clathrin coat assembly domain	0	DIRECT
Third domain of FERM	0	DIRECT
Ephrin ectodomain	0	DIRECT
WW domain	0	DIRECT
UDPGT-like	0	DIRECT
NLI interacting factor-like phosphatase	0	DIRECT
FAD/NAD-linked reductases, N-terminal and central domains	0	DIRECT
beta-glycanases	0	DIRECT
N-acetyl transferase, NAT	0	DIRECT
Phoshatidylinositol transfer protein, PITP	0	DIRECT
MIF4G domain-like	0	DIRECT
Choline kinase	0	DIRECT
CoA transferase alpha subunit-like	0	DIRECT
Bacterial dinuclear zinc exopeptidases	0	DIRECT
beta-CASP RNA-metabolising hydrolases	0	DIRECT
Phoshoinositide 3-kinase (PI3K) helical domain	0	DIRECT
Annexin	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
Polypeptide N-acetylgalactosaminyltransferase 1, N-terminal domain	0	DIRECT
Class II glutamine amidotransferases	0	DIRECT
Paired domain	0	DIRECT
Small-conductance potassium channel	0	DIRECT
MutT-like	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
p120GAP domain-like	0	DIRECT
Poly(ADP-ribose) polymerase, C-terminal domain	0	DIRECT
Choline/Carnitine O-acyltransferase	0	DIRECT
Hect, E3 ligase catalytic domain	0	DIRECT
CCCH zinc finger	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
Ribonuclease H	0	DIRECT
Cystathionine synthase-like	0	DIRECT
ATI-like	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
CUT domain	0	DIRECT
Eukaryotic type KH-domain (KH-domain type I)	0	DIRECT
GABA-aminotransferase-like	0	DIRECT
acyl-CoA oxidase N-terminal domains	0	DIRECT
Hormone receptor domain	0	DIRECT
NOL1/NOP2/sun	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
Histone lysine methyltransferases	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
Ferredoxin reductase FAD-binding domain-like	0	DIRECT
GAPDH-like	0	DIRECT
Protein kinases, catalytic subunit	0.08635	INHERITED FROM: muscle system physiology variant || muscle dystrophy || body muscle dystrophy
Canonical RBD	0.3746	INHERITED FROM: sterile F1 || brood size variant
Nicotinic receptor ligand binding domain-like	0.4062	INHERITED FROM: synaptic transmission variant || nervous system physiology variant
Tandem AAA-ATPase domain	0.451	INHERITED FROM: male fertility reduced || male fertility variant || male sterile
G proteins	0.5068	INHERITED FROM: postsynaptic region physiology variant || synaptic transmission variant || nervous system physiology variant
MSP-like	0.6406	INHERITED FROM: sterile progeny
WD40-repeat	0.9438	INHERITED FROM: dead eggs laid || reduced brood size || brood size variant
LDL receptor-like module	0.9642	INHERITED FROM: fertilization defective