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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

• Disease Ontology (DO) Ontology (DO)
  DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
  
• Human Phenotype (HP) Ontology (HP)
  HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
  
• Mouse Phenotype (MP) Ontology (MP)
  MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
  
• Worm Phenotype (WP) Ontology (WP)
  WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
  
• Yeast Phenotype (YP) Ontology (YP)
  Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
  
• Fly Phenotype (FP) Ontology (FP)
  FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
  
• Fly Anatomy (FA) Ontology (FA)
  FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
  
• Zebrafish Anatomy (ZA) Ontology (ZA)
  ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
  
• Xenopus Anatomy (XA) Ontology (XA)
  XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
  
• Arabidopsis Plant Ontology (AP) Ontology (AP)
  As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
  
• Enzyme Commission (EC) Ontology (EC)
  Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
  
• DrugBank ATC (DB) Ontology (DB)
  In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
  
• UniProtKB KeyWords (KW) Ontology (KW)
  Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
  
• UniProtKB UniPathway (UP) Ontology (UP)
  UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
  

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
  

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
  

Superfamily domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Calpain large subunit, middle domain (domain III)	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
Phospholipase A2, PLA2	0	DIRECT
Immunoglobulin	0	DIRECT
Di-copper centre-containing domain	0	DIRECT
Osmotin, thaumatin-like protein	0	DIRECT
PP2C-like	0	DIRECT
Flavoproteins	0	DIRECT
Rhomboid-like	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
DHS-like NAD/FAD-binding domain	0	DIRECT
Cytochrome b5-like heme/steroid binding domain	0	DIRECT
Sec63 N-terminal domain-like	0	DIRECT
Sm-like ribonucleoproteins	0	DIRECT
RUN domain-like	0	DIRECT
Subtilisin-like	0	DIRECT
Cadherin-like	0	DIRECT
Lipovitellin-phosvitin complex, superhelical domain	0	DIRECT
L domain-like	0	DIRECT
MIR domain	0	DIRECT
Folate-binding domain	0	DIRECT
Chitinase insertion domain	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
PLP-binding barrel	0	DIRECT
SH3-domain	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
Citrate synthase	0	DIRECT
ACP-like	0	DIRECT
Concanavalin A-like lectins/glucanases	0	DIRECT
Pectin lyase-like	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
SAICAR synthase-like	0	DIRECT
DEATH domain	0	DIRECT
SPOC domain-like	0	DIRECT
Diaminopimelate epimerase-like	0	DIRECT
Lipocalins	0	DIRECT
Creatinase/prolidase N-terminal domain	0	DIRECT
Hedgehog/intein (Hint) domain	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
Alpha-L RNA-binding motif	0	DIRECT
Ribosomal protein S18	0	DIRECT
Periplasmic binding protein-like II	0	DIRECT
Small-conductance potassium channel	0	DIRECT
Spermadhesin, CUB domain	0	DIRECT
SMR domain-like	0	DIRECT
CCCH zinc finger	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
Ribulose-phoshate binding barrel	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
Smc hinge domain	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
Carboxypeptidase regulatory domain-like	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
GHMP Kinase, C-terminal domain	0	DIRECT
CRAL/TRIO domain	0	DIRECT
Phospholipase D/nuclease	0	DIRECT
Families 57/38 glycoside transferase middle domain	0	DIRECT
Roadblock/LC7 domain	0	DIRECT
TK C-terminal domain-like	0	DIRECT
UBC-like	0	DIRECT
SNARE-like	0	DIRECT
MgtE membrane domain-like	0	DIRECT
PK beta-barrel domain-like	0	DIRECT
Prefoldin	0	DIRECT
Troponin coil-coiled subunits	0	DIRECT
Ribosomal proteins S24e, L23 and L15e	0	DIRECT
E2F-DP heterodimerization region	0	DIRECT
Tubulin nucleotide-binding domain-like	0	DIRECT
alpha/beta knot	0	DIRECT
Elafin-like	0	DIRECT
Formate/glycerate dehydrogenase catalytic domain-like	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
Aminomethyltransferase beta-barrel domain	0	DIRECT
RmlC-like cupins	0	DIRECT
Phoshotransferase/anion transport protein	0	DIRECT
Acid phosphatase/Vanadium-dependent haloperoxidase	0	DIRECT
HRDC-like	0	DIRECT
3-carboxy-cis,cis-mucoante lactonizing enzyme	0	DIRECT
ArfGap/RecO-like zinc finger	0	DIRECT
WW domain	0	DIRECT
Ribosomal protein S10	0	DIRECT
Bactericidal permeability-increasing protein, BPI	0	DIRECT
FAD-binding/transporter-associated domain-like	0	DIRECT
Cysteine-rich domain	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
Lysozyme-like	0	DIRECT
Hemopexin-like domain	0	DIRECT
SAP domain	0	DIRECT
Doublecortin (DC)	0	DIRECT
Molybdenum cofactor biosynthesis proteins	0	DIRECT
Ferredoxin reductase-like, C-terminal NADP-linked domain	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Tim10-like	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0	DIRECT
HSP20-like chaperones	0	DIRECT
PEP carboxykinase-like	0	DIRECT
Acyl-CoA N-acyltransferases (Nat)	0	DIRECT
Actin-like ATPase domain	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
FAD-linked oxidases, C-terminal domain	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
Glutamine synthetase/guanido kinase	0	DIRECT
GYF domain	0	DIRECT
Mss4-like	0	DIRECT
GroES-like	0	DIRECT
Nucleotide-diphospho-sugar transferases	0	DIRECT
Myosin rod fragments	0	DIRECT
Carbon-nitrogen hydrolase	0	DIRECT
Nucleotide-binding domain	0	DIRECT
Terpenoid synthases	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
Clc chloride channel	0	DIRECT
p53-like transcription factors	0	DIRECT
Ammonium transporter	0	DIRECT
Tubulin C-terminal domain-like	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
TGS-like	0	DIRECT
R3H domain	0	DIRECT
Nop domain	0	DIRECT
NAD kinase/diacylglycerol kinase-like	0	DIRECT
DNA ligase/mRNA capping enzyme, catalytic domain	0	DIRECT
Acyl-CoA dehydrogenase NM domain-like	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
NTF2-like	0	DIRECT
TIMP-like	0	DIRECT
Composite domain of metallo-dependent hydrolases	0	DIRECT
Phosphoglycerate mutase-like	0	DIRECT
SMAD/FHA domain	0	DIRECT
Formin homology 2 domain (FH2 domain)	0	DIRECT
PH domain-like	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
Phosphoenolpyruvate/pyruvate domain	0	DIRECT
Polo-box domain	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
Clavaminate synthase-like	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
Thiolase-like	0	DIRECT
SNARE fusion complex	0	DIRECT
Purple acid phosphatase, N-terminal domain	0	DIRECT
WGR domain-like	0	DIRECT
EF-G C-terminal domain-like	0	DIRECT
PreATP-grasp domain	0	DIRECT
UBA-like	0	DIRECT
Carbonic anhydrase	0	DIRECT
SET domain	0	DIRECT
Activating enzymes of the ubiquitin-like proteins	0	DIRECT
Bet v1-like	0	DIRECT
alpha-catenin/vinculin-like	0	DIRECT
Purine and uridine phosphorylases	0	DIRECT
Cyclophilin-like	0	DIRECT
ABC transporter transmembrane region	0	DIRECT
Actin-crosslinking proteins	0	DIRECT
Cyclin-like	0	DIRECT
SMAD MH1 domain	0	DIRECT
Integrin domains	0	DIRECT
LDH C-terminal domain-like	0	DIRECT
PABC (PABP) domain	0	DIRECT
Mob1/phocein	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
CoA-dependent acyltransferases	0	DIRECT
HIT/MYND zinc finger-like	0	DIRECT
Bromodomain	0	DIRECT
ENTH/VHS domain	0	DIRECT
SAM/Pointed domain	0	DIRECT
Zinc beta-ribbon	0	DIRECT
Chromo domain-like	0	DIRECT
Tropomyosin	0	DIRECT
14-3-3 protein	0	DIRECT
Cystatin/monellin	0	DIRECT
Alkaline phosphatase-like	0	DIRECT
6-phosphogluconate dehydrogenase C-terminal domain-like	0	DIRECT
Cytidine deaminase-like	0	DIRECT
Complement control module/SCR domain	0	DIRECT
FtsH protease domain-like	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Tautomerase/MIF	0	DIRECT
cAMP-binding domain-like	0	DIRECT
MFPT repeat-like	0	DIRECT
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0	DIRECT
t-snare proteins	0	DIRECT
FAD-linked reductases, C-terminal domain	0	DIRECT
Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
alpha-helical ferredoxin	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
LEM domain	0	DIRECT
Cystine-knot cytokines	0	DIRECT
The spindle assembly checkpoint protein mad2	0	DIRECT
BAR/IMD domain-like	0	DIRECT
Eukaryotic type KH-domain (KH-domain type I)	0	DIRECT
Single hybrid motif	0	DIRECT
Transcription factor IIA (TFIIA), beta-barrel domain	0	DIRECT
Rap/Ran-GAP	0	DIRECT
GAT-like domain	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
AN1-like Zinc finger	0	DIRECT
DNA clamp	0	DIRECT
Plexin repeat	0	DIRECT
Fibronectin type III	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
TAZ domain	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
Calcium-dependent phosphotriesterase	0	DIRECT
Serine protease inhibitors	0	DIRECT
CBD9-like	0	DIRECT
ADP-ribosylation	0	DIRECT
RuvA domain 2-like	0	DIRECT
CalX-like	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
Tubby C-terminal domain-like	0	DIRECT
PEBP-like	0	DIRECT
VPS9 domain	0	DIRECT
Kringle-like	0	DIRECT
Glycerol-3-phosphate (1)-acyltransferase	0	DIRECT
Intermediate filament protein, coiled coil region	0	DIRECT
NHL repeat	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
Tricorn protease domain 2	0	DIRECT
ClpP/crotonase	0	DIRECT
C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
Calponin-homology domain, CH-domain	0	DIRECT
Carbohydrate phosphatase	0	DIRECT
FabD/lysophospholipase-like	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
Rhodanese/Cell cycle control phosphatase	0	DIRECT
Riboflavin synthase domain-like	0	DIRECT
Ankyrin repeat	0	DIRECT
Nucleic acid-binding proteins	0	DIRECT
L-aspartase-like	0	DIRECT
Outer arm dynein light chain 1	0	DIRECT
Galactose oxidase, central domain	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
S-adenosyl-L-methionine-dependent methyltransferases	0	DIRECT
Rudiment single hybrid motif	0	DIRECT
Adenine nucleotide alpha hydrolases-like	0	DIRECT
SCP-like	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Translation proteins SH3-like domain	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
Ras GEF	0	DIRECT
Pseudouridine synthase	0	DIRECT
ALDH-like	0	DIRECT
Kelch motif	0	DIRECT
Ypt/Rab-GAP domain of gyp1p	0	DIRECT
Actin depolymerizing proteins	0	DIRECT
ADC-like	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
Putative DNA-binding domain	0	DIRECT
Invertebrate chitin-binding proteins	0	DIRECT
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
Lipovitellin-phosvitin complex; beta-sheet shell regions	0	DIRECT
Galactose mutarotase-like	0	DIRECT
PIN domain-like	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Thioesterase/thiol ester dehydrase-isomerase	0	DIRECT
GAS2 domain-like	0	DIRECT
Arginase/deacetylase	0	DIRECT
LysM domain	0	DIRECT
Periplasmic binding protein-like I	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
PDZ domain-like	0	DIRECT
Ganglioside M2 (gm2) activator	0	DIRECT
ThrRS/AlaRS common domain	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Spectrin repeat	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
Mitochondrial carrier	0	DIRECT
PX domain	0	DIRECT
BRCT domain	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
BolA-like	0	DIRECT
HIT-like	0	DIRECT
SIS domain	0	DIRECT
Hect, E3 ligase catalytic domain	0	DIRECT
Protease propeptides/inhibitors	0	DIRECT
Tetraspanin	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
CAD & PB1 domains	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	0	DIRECT
eIF4e-like	0	DIRECT
DNase I-like	0	DIRECT
Annexin	0	DIRECT
Frizzled cysteine-rich domain	0	DIRECT
Pentein	0	DIRECT
Thiamin diphosphate-binding fold (THDP-binding)	0	DIRECT
Glycoside hydrolase/deacetylase	0	DIRECT
Aldolase	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
AraD/HMP-PK domain-like	0	DIRECT
Hormone receptor domain	0	DIRECT
Chaperone J-domain	0	DIRECT
HCP-like	0	DIRECT
Restriction endonuclease-like	0	DIRECT
Metal cation-transporting ATPase, ATP-binding domain N	0	DIRECT
Transcription factor IIA (TFIIA), alpha-helical domain	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
Ribokinase-like	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
eIF1-like	0	DIRECT
Cytochrome c	0	DIRECT
PYP-like sensor domain (PAS domain)	0	DIRECT
PR-1-like	0	DIRECT
Glycosyl hydrolase domain	0	DIRECT
WWE domain	0	DIRECT
Ferritin-like	0	DIRECT
Heme-dependent peroxidases	0	DIRECT
Six-hairpin glycosidases	0	DIRECT
Cap-Gly domain	0	DIRECT
Heme-dependent catalase-like	0	DIRECT
ARID-like	0	DIRECT
Terpenoid cyclases/Protein prenyltransferases	0	DIRECT
SAND domain-like	0	DIRECT
Translation proteins	0	DIRECT
4Fe-4S ferredoxins	0	DIRECT
PGBD-like	0	DIRECT
CBS-domain pair	0	DIRECT
Cation efflux protein transmembrane domain-like	0	DIRECT
Cupredoxins	0	DIRECT
RCC1/BLIP-II	0	DIRECT
Kix domain of CBP (creb binding protein)	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	DIRECT
Acyl-CoA dehydrogenase C-terminal domain-like	0	DIRECT
FF domain	0	DIRECT
Hairpin loop containing domain-like	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Aquaporin-like	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
Clathrin adaptor appendage domain	0	DIRECT
BSD domain-like	0	DIRECT
HAD-like	0	DIRECT
YbiA-like	0	DIRECT
Integrin alpha N-terminal domain	0	DIRECT
ISP domain	0	DIRECT
L30e-like	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Metallo-dependent hydrolases	0	DIRECT
Calcium ATPase, transduction domain A	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
Class I glutamine amidotransferase-like	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
Calcium ATPase, transmembrane domain M	0	DIRECT
Isocitrate/Isopropylmalate dehydrogenase-like	0	DIRECT
Ricin B-like lectins	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
Band 7/SPFH domain	0	DIRECT
HD-domain/PDEase-like	0	DIRECT
beta-lactamase/transpeptidase-like	0	DIRECT
Radical SAM enzymes	0	DIRECT
B-box zinc-binding domain	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
Mitochondrial cytochrome c oxidase subunit VIc	0	DIRECT
MIT domain	0	DIRECT
Nucleotidyltransferase	0	DIRECT
FAD/NAD(P)-binding domain	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
PRTase-like	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
SGNH hydrolase	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
GroEL equatorial domain-like	0	DIRECT
PUA domain-like	0	DIRECT
NAD(P)-linked oxidoreductase	0	DIRECT
Nucleoporin domain	0	DIRECT
Multidrug resistance efflux transporter EmrE	0	DIRECT
Nudix	0	DIRECT
Subdomain of clathrin and coatomer appendage domain	0	DIRECT
Metallo-hydrolase/oxidoreductase	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
BPTI-like	0	DIRECT
Translational machinery components	0	DIRECT
Acid proteases	0	DIRECT
PAP/OAS1 substrate-binding domain	0	DIRECT
Sema domain	0	DIRECT
NagB/RpiA/CoA transferase-like	0	DIRECT
Oxysterol-binding protein-like	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
PHM/PNGase F	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
SpoIIaa-like	0	DIRECT
Sec7 domain	0	DIRECT
PLC-like phosphodiesterases	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
Glutathione synthetase ATP-binding domain-like	0	DIRECT
Aminoacid dehydrogenase-like, N-terminal domain	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
KA1-like	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Tudor/PWWP/MBT	0	DIRECT
GroEL apical domain-like	0	DIRECT
HMG-box	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
Caspase-like	0	DIRECT
2Fe-2S ferredoxin-like	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Second domain of FERM	0	DIRECT
lambda repressor-like DNA-binding domains	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
Nucleotide cyclase	0	DIRECT
BEACH domain	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
Ribosomal protein L1	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
RNA-binding domain, RBD	0.1915	INHERITED FROM: sterile F1 || brood size variant
Nicotinic receptor ligand binding domain-like	0.2541	INHERITED FROM: nervous system physiology variant || synaptic transmission variant
Neurotransmitter-gated ion-channel transmembrane pore	0.3066	INHERITED FROM: nervous system physiology variant || synaptic transmission variant
Ubiquitin-like	0.3461	INHERITED FROM: body muscle dystrophy || muscle system physiology variant || muscle dystrophy
ARM repeat	0.4622	INHERITED FROM: brood size variant
FYVE/PHD zinc finger	0.509	INHERITED FROM: transgenerational loss of fertility
WD40 repeat-like	0.6298	INHERITED FROM: reduced brood size || brood size variant
EF-hand	0.6899	INHERITED FROM: gonad sheath contractions variant || somatic gonad physiology variant || somatic sheath physiology variant
EGF/Laminin	0.791	INHERITED FROM: nervous system physiology variant
"Winged helix" DNA-binding domain	0.8684	INHERITED FROM: body muscle dystrophy || muscle system physiology variant || muscle dystrophy || brood size variant
P-loop containing nucleoside triphosphate hydrolases	0.9157	INHERITED FROM: nervous system physiology variant || postsynaptic region physiology variant || brood size variant
PapD-like	0.9709	INHERITED FROM: sterile progeny
LDL receptor-like module	0.9743	INHERITED FROM: fertilization defective
Protein kinase-like (PK-like)	0.9973	INHERITED FROM: body muscle dystrophy || muscle system physiology variant || muscle dystrophy

Family domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Carbonic anhydrase	0	DIRECT
Ephrin ectodomain	0	DIRECT
Myeloperoxidase-like	0	DIRECT
Polo-box duplicated region	0	DIRECT
Synaptotagmin-like (S variant)	0	DIRECT
Peptidylglycine alpha-hydroxylating monooxygenase, PHM	0	DIRECT
SPRY domain	0	DIRECT
alpha-mannosidase, domain 2	0	DIRECT
alpha-mannosidase, C-terminal domain	0	DIRECT
Second domain of FERM	0	DIRECT
TAZ domain	0	DIRECT
Arylamine N-methyltransferase	0	DIRECT
Actin/HSP70	0	DIRECT
Calcium ATPase, transmembrane domain M	0	DIRECT
Bromodomain	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
YbiA-like	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
L30e/L7ae ribosomal proteins	0	DIRECT
MIF-related	0	DIRECT
MIR domain	0	DIRECT
XPF/Rad1/Mus81 nuclease	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	0	DIRECT
Third domain of FERM	0	DIRECT
Adenosine/AMP deaminase	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
Rhomboid-like	0	DIRECT
Pseudouridine synthase I TruA	0	DIRECT
LIM domain	0	DIRECT
LEM domain	0	DIRECT
Bactericidal permeability-increasing protein, BPI	0	DIRECT
Sec63 N-terminal domain	0	DIRECT
Diap1 N-terninal region-like	0	DIRECT
Serine carboxypeptidase-like	0	DIRECT
t-snare proteins	0	DIRECT
Pancreatic carboxypeptidases	0	DIRECT
Nucleotide and nucleoside kinases	0	DIRECT
Small Kunitz-type inhibitors & BPTI-like toxins	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
D-aminoacid oxidase-like	0	DIRECT
CRAL/TRIO domain	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
4HBT-like	0	DIRECT
Meta-cation ATPase, catalytic domain P	0	DIRECT
CoA transferase alpha subunit-like	0	DIRECT
Cell cycle control phosphatase, catalytic domain	0	DIRECT
ZZ domain	0	DIRECT
PUA domain	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
Hemopexin-like domain	0	DIRECT
Kinase associated domain 1, KA1	0	DIRECT
Ammonium transporter	0	DIRECT
PhzC/PhzF-like	0	DIRECT
B-box zinc-binding domain	0	DIRECT
Tropomyosin	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
BEACH domain	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Adenain-like	0	DIRECT
HMG-box	0	DIRECT
Carboxylesterase	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Arginine methyltransferase	0	DIRECT
CO dehydrogenase flavoprotein N-terminal domain-like	0	DIRECT
Ganglioside M2 (gm2) activator	0	DIRECT
Caspase catalytic domain	0	DIRECT
YihX-like	0	DIRECT
Laminin-type module	0	DIRECT
Osmotin, thaumatin-like protein	0	DIRECT
H-NOX domain	0	DIRECT
Proprotein convertase P-domain	0	DIRECT
PDI-like	0	DIRECT
Ypt/Rab-GAP domain of gyp1p	0	DIRECT
alpha-Amylases, C-terminal beta-sheet domain	0	DIRECT
Poly(A) polymerase, PAP, middle domain	0	DIRECT
Phosphatidylethanolamine binding protein	0	DIRECT
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain	0	DIRECT
Pleckstrin-homology domain (PH domain)	0	DIRECT
MFPT repeat	0	DIRECT
FF domain	0	DIRECT
Linker histone H1/H5	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
UBC-related	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
Calcium ATPase, transduction domain A	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
Eukaryotic type KH-domain (KH-domain type I)	0	DIRECT
Complement control module/SCR domain	0	DIRECT
Cyclophilin (peptidylprolyl isomerase)	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
Smc hinge domain	0	DIRECT
N-type ATP pyrophosphatases	0	DIRECT
FYVE, a phosphatidylinositol-3-phosphate binding domain	0	DIRECT
Aminomethyltransferase folate-binding domain	0	DIRECT
Choline kinase	0	DIRECT
Elongation factors	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Acireductone dioxygenase	0	DIRECT
NagD-like	0	DIRECT
Formate/glycerate dehydrogenases, NAD-domain	0	DIRECT
GAS2 domain	0	DIRECT
Biotinyl/lipoyl-carrier proteins and domains	0	DIRECT
Serpins	0	DIRECT
Ribonuclease PH domain 1-like	0	DIRECT
Roadblock/LC7 domain	0	DIRECT
Trunk domain of Sec23/24	0	DIRECT
PP2C-like	0	DIRECT
Thiolase-related	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
Protein prenyltransferases	0	DIRECT
Lactate & malate dehydrogenases, C-terminal domain	0	DIRECT
PABC (PABP) domain	0	DIRECT
HEAT repeat	0	DIRECT
Fibronectin type III	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
Clathrin coat assembly domain	0	DIRECT
HSP20	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
L-aminoacid/polyamine oxidase	0	DIRECT
Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
BolA-like	0	DIRECT
Polypeptide N-acetylgalactosaminyltransferase 1, N-terminal domain	0	DIRECT
Kelch motif	0	DIRECT
Acylamino-acid-releasing enzyme, C-terminal donain	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain	0	DIRECT
Rap/Ran-GAP	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
FHA domain	0	DIRECT
Glycerophosphoryl diester phosphodiesterase	0	DIRECT
GHMP Kinase, N-terminal domain	0	DIRECT
Purine and uridine phosphorylases	0	DIRECT
First domain of FERM	0	DIRECT
UBX domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Formin homology 2 domain (FH2 domain)	0	DIRECT
EF-hand modules in multidomain proteins	0	DIRECT
AN1-like Zinc finger	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
DNA replication initiator (cdc21/cdc54) N-terminal domain	0	DIRECT
Galectin (animal S-lectin)	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
Poly(A) polymerase, PAP, C-terminal domain	0	DIRECT
UDPGT-like	0	DIRECT
UDP-glucose pyrophosphorylase	0	DIRECT
Cyclin	0	DIRECT
Myosin rod fragments	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
CUT domain	0	DIRECT
ets domain	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
CBS-domain pair	0	DIRECT
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta	0	DIRECT
Methionine aminopeptidase, insert domain	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
Annexin	0	DIRECT
Hedgehog C-terminal (Hog) autoprocessing domain	0	DIRECT
BTB/POZ domain	0	DIRECT
RhoGDI-like	0	DIRECT
VHS domain	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
Multidomain sulfurtransferase (rhodanese)	0	DIRECT
E2F dimerization segment	0	DIRECT
1,3-glucuronyltransferase	0	DIRECT
Histone deacetylase, HDAC	0	DIRECT
Alcohol dehydrogenase-like, N-terminal domain	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	0	DIRECT
Type II chitinase	0	DIRECT
BC ATP-binding domain-like	0	DIRECT
Cofilin-like	0	DIRECT
acyl-CoA oxidase N-terminal domains	0	DIRECT
SAM (sterile alpha motif) domain	0	DIRECT
FtsH protease domain-like	0	DIRECT
Elafin-like	0	DIRECT
SNARE fusion complex	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Pyridoxal-dependent decarboxylase	0	DIRECT
Ribosomal protein L1	0	DIRECT
STAR domain	0	DIRECT
RNA-polymerase beta	0	DIRECT
Class II glutamine amidotransferases	0	DIRECT
beta-CASP RNA-metabolising hydrolases	0	DIRECT
CoA-binding domain	0	DIRECT
Patatin	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
EF-G/eEF-2 domains III and V	0	DIRECT
Cytochrome b5	0	DIRECT
L domain	0	DIRECT
RIO1-like kinases	0	DIRECT
Pyk2-associated protein beta ARF-GAP domain	0	DIRECT
BC C-terminal domain-like	0	DIRECT
Cytoplasmic domain of inward rectifier potassium channel	0	DIRECT
Amylase, catalytic domain	0	DIRECT
Mammalian PLC	0	DIRECT
ARID domain	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
GAPDH-like	0	DIRECT
SMAD domain	0	DIRECT
Tudor domain	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
FAD-linked reductases, N-terminal domain	0	DIRECT
Guanido kinase catalytic domain	0	DIRECT
Frizzled cysteine-rich domain	0	DIRECT
Aminoacid dehydrogenase-like, C-terminal domain	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
NHL repeat	0	DIRECT
Zf-UBP	0	DIRECT
Ribosomal protein S18	0	DIRECT
Tubulin, GTPase domain	0	DIRECT
Myotubularin-like phosphatases	0	DIRECT
Aquaporin-like	0	DIRECT
Transcription factor IIA (TFIIA), beta-barrel domain	0	DIRECT
PR-1-like	0	DIRECT
Proteasome subunits	0	DIRECT
Ribonuclease H	0	DIRECT
N-acetylglucosaminyltransferase I	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
Reductases	0	DIRECT
Transcription factor IIA (TFIIA), alpha-helical domain	0	DIRECT
PDEase	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
Calmodulin-like	0	DIRECT
Intermediate filament protein, coiled coil region	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
Spectrin repeat	0	DIRECT
Calpain large subunit, catalytic domain (domain II)	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain	0	DIRECT
Chaperone J-domain	0	DIRECT
Mo25 protein	0	DIRECT
CalX-beta domain	0	DIRECT
Cystathionine synthase-like	0	DIRECT
Phoshoinositide 3-kinase (PI3K) helical domain	0	DIRECT
Mob1/phocein	0	DIRECT
CAT-like	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
ATI-like	0	DIRECT
Anticodon-binding domain	0	DIRECT
Acyl-CoA thioesterase	0	DIRECT
Hemocyanin middle domain	0	DIRECT
Adenylyl and guanylyl cyclase catalytic domain	0	DIRECT
Phoshatidylinositol transfer protein, PITP	0	DIRECT
Chromo domain	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
SMAD MH1 domain	0	DIRECT
14-3-3 protein	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
BSD domain	0	DIRECT
Cytidylyltransferase	0	DIRECT
Epoxide hydrolase	0	DIRECT
AraD-like aldolase/epimerase	0	DIRECT
Cdc48 N-terminal domain-like	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
Rv2717c-like	0	DIRECT
Lipovitellin-phosvitin complex, superhelical domain	0	DIRECT
Ribosomal protein L18 and S11	0	DIRECT
SAP domain	0	DIRECT
Family 19 glycosidase	0	DIRECT
Ngr ectodomain-like	0	DIRECT
Ankyrin repeat	0	DIRECT
PX domain	0	DIRECT
Plexin repeat	0	DIRECT
6-phosphogluconate dehydrogenase-like, N-terminal domain	0	DIRECT
MIT domain	0	DIRECT
cAMP-binding domain	0	DIRECT
D-aminoacid oxidase, N-terminal domain	0	DIRECT
COMT-like	0	DIRECT
Regulator of chromosome condensation RCC1	0	DIRECT
Deoxycytidylate deaminase-like	0	DIRECT
Serum paraoxonase/arylesterase 1, PON1	0	DIRECT
Acyl-carrier protein (ACP)	0	DIRECT
Glycerol kinase	0	DIRECT
Tim10/DDP	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
Eps15 homology domain (EH domain)	0	DIRECT
Erythroid transcription factor GATA-1	0	DIRECT
WWE domain	0	DIRECT
alpha-mannosidase	0	DIRECT
Phoshoinositide 3-kinase (PI3K), catalytic domain	0	DIRECT
Dimeric isocitrate & isopropylmalate dehydrogenases	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
RecA protein-like (ATPase-domain)	0	DIRECT
Phosphate binding protein-like	0	DIRECT
Arfaptin, Rac-binding fragment	0	DIRECT
Hydantoinase (dihydropyrimidinase)	0	DIRECT
POU-specific domain	0	DIRECT
Glycogenin	0	DIRECT
Paired domain	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase PP module	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
ATP-dependent protease Lon (La), catalytic domain	0	DIRECT
SWIRM domain	0	DIRECT
Transcriptional factor domain	0	DIRECT
Ferredoxin reductase FAD-binding domain-like	0	DIRECT
Leukotriene A4 hydrolase catalytic domain	0	DIRECT
Citrate synthase	0	DIRECT
Pepsin-like	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
beta 1,4 galactosyltransferase (b4GalT1)	0	DIRECT
Cell cycle transcription factor e2f-dp	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
Smr domain	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
Inositol polyphosphate kinase (IPK)	0	DIRECT
F-box domain	0	DIRECT
Integrin A (or I) domain	0	DIRECT
Laminin G-like module	0	DIRECT
Autophagin-like	0	DIRECT
TatD Mg-dependent DNase-like	0	DIRECT
NLI interacting factor-like phosphatase	0	DIRECT
GYF domain	0	DIRECT
MutT-like	0	DIRECT
Sm motif of small nuclear ribonucleoproteins, SNRNP	0	DIRECT
Sec63 C-terminal domain-like	0	DIRECT
Heme-dependent catalases	0	DIRECT
FCH domain	0	DIRECT
Cap-Gly domain	0	DIRECT
NADPH-cytochrome p450 reductase FAD-binding domain-like	0	DIRECT
Bacterial lipase	0	DIRECT
Pancreatic carboxypeptidase, activation domain	0	DIRECT
PaaI/YdiI-like	0	DIRECT
Classic zinc finger, C2H2	0	DIRECT
L-arabinose binding protein-like	0	DIRECT
Trehalase-like	0	DIRECT
Spermadhesin, CUB domain	0	DIRECT
DPP6 catalytic domain-like	0	DIRECT
UBA domain	0	DIRECT
Ricin B-like	0	DIRECT
GABA-aminotransferase-like	0	DIRECT
Calponin-homology domain, CH-domain	0	DIRECT
WGR domain	0	DIRECT
HD domain	0	DIRECT
YicI catalytic domain-like	0	DIRECT
Pumilio repeat	0	DIRECT
Translation initiation factor eIF4e	0	DIRECT
Cold shock DNA-binding domain-like	0	DIRECT
Group II chaperonin (CCT, TRIC), apical domain	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
NADPH-cytochrome p450 reductase-like	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
Hormone receptor domain	0	DIRECT
CCCH zinc finger	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
Arylsulfatase	0	DIRECT
Single strand DNA-binding domain, SSB	0	DIRECT
Ubiquitin-related	0	DIRECT
Neurolysin-like	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Lesion bypass DNA polymerase (Y-family), catalytic domain	0	DIRECT
Class I alpha-1;2-mannosidase, catalytic domain	0	DIRECT
IF2B-like	0	DIRECT
Neurotransmitter-gated ion-channel transmembrane pore	0	DIRECT
Subtilases	0	DIRECT
Translational machinery components	0	DIRECT
5' to 3' exonuclease catalytic domain	0	DIRECT
Group II chaperonin (CCT, TRIC), ATPase domain	0	DIRECT
RNA editing terminal uridyl transferase 2, RET2, domain 2	0	DIRECT
Metal cation-transporting ATPase, ATP-binding domain N	0	DIRECT
Reprolysin-like	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
Ras GEF	0	DIRECT
PDZ domain	0	DIRECT
Calpain large subunit, middle domain (domain III)	0	DIRECT
Poly(A) polymerase, PAP, N-terminal domain	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
LysM domain	0	DIRECT
Integrin domains	0	DIRECT
Gastric lipase	0	DIRECT
Nop domain	0	DIRECT
DEP domain	0	DIRECT
BAR domain	0	DIRECT
Ubiquitin activating enzymes (UBA)	0	DIRECT
HAT/Suf repeat	0	DIRECT
BC N-terminal domain-like	0	DIRECT
U-box	0	DIRECT
Doublecortin (DC)	0	DIRECT
Tetramerization domain of potassium channels	0	DIRECT
ABC transporter transmembrane region	0	DIRECT
Ribokinase-like	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Filamin repeat (rod domain)	0	DIRECT
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains	0	DIRECT
Small-conductance potassium channel	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Band 7/SPFH domain	0	DIRECT
beta-Lactamase/D-ala carboxypeptidase	0	DIRECT
Kix domain of CBP (creb binding protein)	0	DIRECT
Gelsolin-like	0	DIRECT
AMPK-beta glycogen binding domain-like	0	DIRECT
Sec7 domain	0	DIRECT
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)	0	DIRECT
Myb/SANT domain	0	DIRECT
Phosphoribosyltransferases (PRTases)	0	DIRECT
LDH N-terminal domain-like	0	DIRECT
Fungal lipases	0	DIRECT
PEP carboxykinase C-terminal domain	0	DIRECT
Purple acid phosphatase-like	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
acyl-CoA oxidase C-terminal domains	0	DIRECT
Gamma-glutamyltranspeptidase-like	0	DIRECT
SH3-domain	0	DIRECT
Histone lysine methyltransferases	0	DIRECT
La domain	0	DIRECT
Sterol carrier protein, SCP	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase Pyr module	0	DIRECT
WW domain	0	DIRECT
LacY-like proton/sugar symporter	0	DIRECT
MIF4G domain-like	0	DIRECT
Cation efflux protein transmembrane domain-like	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
Chitinase insertion domain	0	DIRECT
RNA-polymerase beta-prime	0	DIRECT
Crotonase-like	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
alpha-catenin/vinculin	0	DIRECT
AlkB-like	0	DIRECT
PLC-like (P variant)	0	DIRECT
Sema domain	0	DIRECT
Tubulin, C-terminal domain	0	DIRECT
Class I glutamine amidotransferases (GAT)	0	DIRECT
Ras-binding domain, RBD	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
28-residue LRR	0	DIRECT
Internalin LRR domain	0	DIRECT
Anticodon-binding domain of Class II aaRS	0	DIRECT
Glycerol-3-phosphate transporter	0	DIRECT
Nitrogenase iron protein-like	0	DIRECT
Hect, E3 ligase catalytic domain	0	DIRECT
Fatty acid binding protein-like	0	DIRECT
Lipovitellin-phosvitin complex; beta-sheet shell regions	0	DIRECT
RNA methyltransferase FtsJ	0	DIRECT
Catalytic, N-terminal domain of histone methyltransferase Dot1l	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
Glutaminase	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
Inositol monophosphatase/fructose-1,6-bisphosphatase-like	0	DIRECT
Histidine acid phosphatase	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
Troponin I	0	DIRECT
Cadherin	0	DIRECT
Bacterial dinuclear zinc exopeptidases	0	DIRECT
Poly(ADP-ribose) polymerase, C-terminal domain	0	DIRECT
p120GAP domain-like	0	DIRECT
RING finger domain, C3HC4	0	DIRECT
HCDH C-domain-like	0	DIRECT
Papain-like	0	DIRECT
RUN domain	0	DIRECT
PhyH-like	0	DIRECT
Clc chloride channel	0	DIRECT
Carboxypeptidase regulatory domain	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Purple acid phosphatase, N-terminal domain	0	DIRECT
NTF2-like	0	DIRECT
Clathrin adaptor core protein	0	DIRECT
Oxysterol-binding protein	0	DIRECT
Astacin	0	DIRECT
Ferredoxin domains from multidomain proteins	0	DIRECT
Mitochondrial carrier	0	DIRECT
Glutamine synthetase catalytic domain	0	DIRECT
Alcohol dehydrogenase-like, C-terminal domain	0	DIRECT
Hsp90 middle domain	0	DIRECT
ALDH-like	0	DIRECT
Phosphotyrosine-binding domain (PTB)	0	DIRECT
T-box	0	DIRECT
Prefoldin	0	DIRECT
TBP-associated factors, TAFs	0	DIRECT
Class I aldolase	0	DIRECT
Aldo-keto reductases (NADP)	0	DIRECT
Hexokinase	0	DIRECT
Hydantoinase (dihydropyrimidinase), catalytic domain	0	DIRECT
Ribosomal protein S10	0	DIRECT
Hermes transposase-like	0	DIRECT
SAND domain	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
FAD/NAD-linked reductases, N-terminal and central domains	0	DIRECT
Tetraspanin	0	DIRECT
NOL1/NOP2/sun	0	DIRECT
Choline/Carnitine O-acyltransferase	0	DIRECT
eIF1-like	0	DIRECT
Biotin dependent carboxylase carboxyltransferase domain	0	DIRECT
Sir2 family of transcriptional regulators	0	DIRECT
Aminomethyltransferase beta-barrel domain	0	DIRECT
N-acetyl transferase, NAT	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
Armadillo repeat	0	DIRECT
2Fe-2S ferredoxin domains from multidomain proteins	0	DIRECT
Matrix metalloproteases, catalytic domain	0	DIRECT
I set domains	0	DIRECT
beta-glycanases	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
Transforming growth factor (TGF)-beta	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
Dual specificity phosphatase-like	0	DIRECT
DEATH domain, DD	0	DIRECT
Inositol polyphosphate 5-phosphatase (IPP5)	0	DIRECT
Canonical RBD	0.2261	INHERITED FROM: sterile F1 || brood size variant
Nicotinic receptor ligand binding domain-like	0.2551	INHERITED FROM: nervous system physiology variant || synaptic transmission variant
Tandem AAA-ATPase domain	0.3183	INHERITED FROM: male sterile || male fertility variant || male fertility reduced
G proteins	0.4443	INHERITED FROM: nervous system physiology variant || postsynaptic region physiology variant || synaptic transmission variant
Protein kinases, catalytic subunit	0.7384	INHERITED FROM: body muscle dystrophy || muscle system physiology variant || muscle dystrophy
WD40-repeat	0.7774	INHERITED FROM: reduced brood size || brood size variant
LDL receptor-like module	0.9258	INHERITED FROM: fertilization defective
MSP-like	0.9353	INHERITED FROM: sterile progeny