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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

• Disease Ontology (DO) Ontology (DO)
  DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
  
• Human Phenotype (HP) Ontology (HP)
  HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
  
• Mouse Phenotype (MP) Ontology (MP)
  MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
  
• Worm Phenotype (WP) Ontology (WP)
  WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
  
• Yeast Phenotype (YP) Ontology (YP)
  Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
  
• Fly Phenotype (FP) Ontology (FP)
  FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
  
• Fly Anatomy (FA) Ontology (FA)
  FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
  
• Zebrafish Anatomy (ZA) Ontology (ZA)
  ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
  
• Xenopus Anatomy (XA) Ontology (XA)
  XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
  
• Arabidopsis Plant Ontology (AP) Ontology (AP)
  As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
  
• Enzyme Commission (EC) Ontology (EC)
  Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
  
• DrugBank ATC (DB) Ontology (DB)
  In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
  
• UniProtKB KeyWords (KW) Ontology (KW)
  Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
  
• UniProtKB UniPathway (UP) Ontology (UP)
  UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
  

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
  

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
  

Superfamily domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
ADC-like	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
ENTH/VHS domain	0	DIRECT
AN1-like Zinc finger	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
BSD domain-like	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
SET domain	0	DIRECT
Terpenoid cyclases/Protein prenyltransferases	0	DIRECT
L-aspartase-like	0	DIRECT
AraD/HMP-PK domain-like	0	DIRECT
CBS-domain pair	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
Cysteine-rich domain	0	DIRECT
PYP-like sensor domain (PAS domain)	0	DIRECT
Concanavalin A-like lectins/glucanases	0	DIRECT
Citrate synthase	0	DIRECT
Small-conductance potassium channel	0	DIRECT
Caspase-like	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
Glycosyl hydrolase domain	0	DIRECT
Acyl-CoA N-acyltransferases (Nat)	0	DIRECT
Carbon-nitrogen hydrolase	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
Phospholipase A2, PLA2	0	DIRECT
Cap-Gly domain	0	DIRECT
BRCT domain	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
PLP-binding barrel	0	DIRECT
VPS9 domain	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
Prefoldin	0	DIRECT
FAD/NAD(P)-binding domain	0	DIRECT
KA1-like	0	DIRECT
Cation efflux protein transmembrane domain-like	0	DIRECT
R3H domain	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
BolA-like	0	DIRECT
Frizzled cysteine-rich domain	0	DIRECT
Ras GEF	0	DIRECT
Molybdenum cofactor biosynthesis proteins	0	DIRECT
HIT-like	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
2Fe-2S ferredoxin-like	0	DIRECT
NAD(P)-linked oxidoreductase	0	DIRECT
Heme-dependent peroxidases	0	DIRECT
Carbohydrate phosphatase	0	DIRECT
Translational machinery components	0	DIRECT
Lipocalins	0	DIRECT
L30e-like	0	DIRECT
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
TRAF domain-like	0	DIRECT
DEATH domain	0	DIRECT
Diaminopimelate epimerase-like	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
Kringle-like	0	DIRECT
RCC1/BLIP-II	0	DIRECT
PreATP-grasp domain	0	DIRECT
TGS-like	0	DIRECT
Hormone receptor domain	0	DIRECT
SMAD MH1 domain	0	DIRECT
Multidrug resistance efflux transporter EmrE	0	DIRECT
Mitochondrial cytochrome c oxidase subunit VIc	0	DIRECT
Composite domain of metallo-dependent hydrolases	0	DIRECT
Galactose oxidase, central domain	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
RmlC-like cupins	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Roadblock/LC7 domain	0	DIRECT
Cyclophilin-like	0	DIRECT
HCP-like	0	DIRECT
Ribosomal protein L1	0	DIRECT
Ricin B-like lectins	0	DIRECT
Acid phosphatase/Vanadium-dependent haloperoxidase	0	DIRECT
PRTase-like	0	DIRECT
HRDC-like	0	DIRECT
PK beta-barrel domain-like	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Cytidine deaminase-like	0	DIRECT
ALDH-like	0	DIRECT
Isocitrate/Isopropylmalate dehydrogenase-like	0	DIRECT
Lysozyme-like	0	DIRECT
DHS-like NAD/FAD-binding domain	0	DIRECT
MFPT repeat-like	0	DIRECT
PEP carboxykinase-like	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
Tubby C-terminal domain-like	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
14-3-3 protein	0	DIRECT
WWE domain	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
alpha/beta-Hydrolases	0	DIRECT
Oxysterol-binding protein-like	0	DIRECT
Rap/Ran-GAP	0	DIRECT
Mss4-like	0	DIRECT
Chromo domain-like	0	DIRECT
BEACH domain	0	DIRECT
TK C-terminal domain-like	0	DIRECT
PLP-dependent transferases	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
Bet v1-like	0	DIRECT
Hairpin loop containing domain-like	0	DIRECT
Transcription factor IIA (TFIIA), beta-barrel domain	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
Formin homology 2 domain (FH2 domain)	0	DIRECT
Ribosomal protein S18	0	DIRECT
Cytochrome c	0	DIRECT
LysM domain	0	DIRECT
Translation proteins SH3-like domain	0	DIRECT
WGR domain-like	0	DIRECT
Lipovitellin-phosvitin complex, superhelical domain	0	DIRECT
Formate/glycerate dehydrogenase catalytic domain-like	0	DIRECT
Nucleotide-binding domain	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
4Fe-4S ferredoxins	0	DIRECT
ThrRS/AlaRS common domain	0	DIRECT
Band 7/SPFH domain	0	DIRECT
PH domain-like	0	DIRECT
PIN domain-like	0	DIRECT
Plexin repeat	0	DIRECT
alpha/beta knot	0	DIRECT
alpha-helical ferredoxin	0	DIRECT
RuvA domain 2-like	0	DIRECT
Sema domain	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
Tubulin C-terminal domain-like	0	DIRECT
FF domain	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Intermediate filament protein, coiled coil region	0	DIRECT
Metallo-hydrolase/oxidoreductase	0	DIRECT
Phoshotransferase/anion transport protein	0	DIRECT
The spindle assembly checkpoint protein mad2	0	DIRECT
Aldolase	0	DIRECT
Rhomboid-like	0	DIRECT
Tudor/PWWP/MBT	0	DIRECT
Creatinase/prolidase N-terminal domain	0	DIRECT
L domain-like	0	DIRECT
Metallo-dependent hydrolases	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
Lipovitellin-phosvitin complex; beta-sheet shell regions	0	DIRECT
Periplasmic binding protein-like I	0	DIRECT
Activating enzymes of the ubiquitin-like proteins	0	DIRECT
GroES-like	0	DIRECT
RUN domain-like	0	DIRECT
Transcription factor IIA (TFIIA), alpha-helical domain	0	DIRECT
FAD-linked reductases, C-terminal domain	0	DIRECT
ARID-like	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
LDH C-terminal domain-like	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
Annexin	0	DIRECT
Sec7 domain	0	DIRECT
GAS2 domain-like	0	DIRECT
UBA-like	0	DIRECT
Clc chloride channel	0	DIRECT
Nop domain	0	DIRECT
Families 57/38 glycoside transferase middle domain	0	DIRECT
Nudix	0	DIRECT
Integrin alpha N-terminal domain	0	DIRECT
ACP-like	0	DIRECT
Calponin-homology domain, CH-domain	0	DIRECT
Thiamin diphosphate-binding fold (THDP-binding)	0	DIRECT
CAD & PB1 domains	0	DIRECT
FabD/lysophospholipase-like	0	DIRECT
Complement control module/SCR domain	0	DIRECT
Chaperone J-domain	0	DIRECT
Cytochrome b5-like heme/steroid binding domain	0	DIRECT
Clathrin adaptor appendage domain	0	DIRECT
SAND domain-like	0	DIRECT
Mitochondrial carrier	0	DIRECT
Immunoglobulin	0	DIRECT
Galactose-binding domain-like	0	DIRECT
Pseudouridine synthase	0	DIRECT
Sec63 N-terminal domain-like	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
Thiolase-like	0	DIRECT
Translation proteins	0	DIRECT
beta-lactamase/transpeptidase-like	0	DIRECT
LEM domain	0	DIRECT
EF-G C-terminal domain-like	0	DIRECT
HSP20-like chaperones	0	DIRECT
Kix domain of CBP (creb binding protein)	0	DIRECT
Tim10-like	0	DIRECT
t-snare proteins	0	DIRECT
Ribosomal protein S10	0	DIRECT
DNase I-like	0	DIRECT
DNA ligase/mRNA capping enzyme, catalytic domain	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
Nucleoporin domain	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
Ankyrin repeat	0	DIRECT
Kelch motif	0	DIRECT
Heme-dependent catalase-like	0	DIRECT
CRAL/TRIO domain	0	DIRECT
Cupredoxins	0	DIRECT
SAM/Pointed domain	0	DIRECT
Glycoside hydrolase/deacetylase	0	DIRECT
Rhodanese/Cell cycle control phosphatase	0	DIRECT
Alpha-L RNA-binding motif	0	DIRECT
CoA-dependent acyltransferases	0	DIRECT
Sm-like ribonucleoproteins	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
Tropomyosin	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
Phosphoenolpyruvate/pyruvate domain	0	DIRECT
FAD-binding/transporter-associated domain-like	0	DIRECT
Radical SAM enzymes	0	DIRECT
Ferredoxin reductase-like, C-terminal NADP-linked domain	0	DIRECT
PAP/OAS1 substrate-binding domain	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	0	DIRECT
PEBP-like	0	DIRECT
GroEL apical domain-like	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
CalX-like	0	DIRECT
FAD-linked oxidases, C-terminal domain	0	DIRECT
Ferritin-like	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
SPOC domain-like	0	DIRECT
Polo-box domain	0	DIRECT
Di-copper centre-containing domain	0	DIRECT
PAZ domain	0	DIRECT
Serpins	0	DIRECT
Ribulose-phoshate binding barrel	0	DIRECT
Acyl-CoA dehydrogenase NM domain-like	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
eIF4e-like	0	DIRECT
PUA domain-like	0	DIRECT
lambda repressor-like DNA-binding domains	0	DIRECT
ClpP/crotonase	0	DIRECT
Bromodomain	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
Invertebrate chitin-binding proteins	0	DIRECT
SGNH hydrolase	0	DIRECT
PR-1-like	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
SNF-like	0	DIRECT
SMAD/FHA domain	0	DIRECT
PX domain	0	DIRECT
Troponin coil-coiled subunits	0	DIRECT
DNA clamp	0	DIRECT
Tetraspanin	0	DIRECT
Terpenoid synthases	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Hedgehog/intein (Hint) domain	0	DIRECT
Folate-binding domain	0	DIRECT
BPTI-like	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Glutamine synthetase/guanido kinase	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
Integrin domains	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Six-hairpin glycosidases	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
Cystatin/monellin	0	DIRECT
ISP domain	0	DIRECT
Second domain of FERM	0	DIRECT
Doublecortin (DC)	0	DIRECT
Fibronectin type III	0	DIRECT
WW domain	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
Actin-like ATPase domain	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
Nucleotide cyclase	0	DIRECT
Tautomerase/MIF	0	DIRECT
Class I glutamine amidotransferase-like	0	DIRECT
Ribosomal proteins S24e, L23 and L15e	0	DIRECT
S-adenosyl-L-methionine-dependent methyltransferases	0	DIRECT
Spectrin repeat	0	DIRECT
Bactericidal permeability-increasing protein, BPI	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
Nucleic acid-binding proteins	0	DIRECT
FtsH protease domain-like	0	DIRECT
Riboflavin synthase domain-like	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
6-phosphogluconate dehydrogenase C-terminal domain-like	0	DIRECT
CBD9-like	0	DIRECT
HMG-box	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
UBC-like	0	DIRECT
Aquaporin-like	0	DIRECT
Tricorn protease domain 2	0	DIRECT
GAT-like domain	0	DIRECT
Pentein	0	DIRECT
PDZ domain-like	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
RNI-like	0	DIRECT
GroEL equatorial domain-like	0	DIRECT
Nucleotidyltransferase	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
3-carboxy-cis,cis-mucoante lactonizing enzyme	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Calcium ATPase, transmembrane domain M	0	DIRECT
Eukaryotic type KH-domain (KH-domain type I)	0	DIRECT
E2F-DP heterodimerization region	0	DIRECT
Apyrase	0	DIRECT
Ganglioside M2 (gm2) activator	0	DIRECT
Galactose mutarotase-like	0	DIRECT
PLC-like phosphodiesterases	0	DIRECT
Subtilisin-like	0	DIRECT
Purple acid phosphatase, N-terminal domain	0	DIRECT
Purine and uridine phosphorylases	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
HAD-like	0	DIRECT
eIF1-like	0	DIRECT
LuxS/MPP-like metallohydrolase	0	DIRECT
SAICAR synthase-like	0	DIRECT
PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	DIRECT
Cadherin-like	0	DIRECT
PABC (PABP) domain	0	DIRECT
GYF domain	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Metalloproteases ("zincins"), catalytic domain	0	DIRECT
NagB/RpiA/CoA transferase-like	0	DIRECT
Glutathione synthetase ATP-binding domain-like	0	DIRECT
Calpain large subunit, middle domain (domain III)	0	DIRECT
Subdomain of clathrin and coatomer appendage domain	0	DIRECT
ArfGap/RecO-like zinc finger	0	DIRECT
dsRNA-binding domain-like	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
Carboxypeptidase regulatory domain-like	0	DIRECT
YbiA-like	0	DIRECT
Elafin-like	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
SH2 domain	0	DIRECT
Metallo-dependent phosphatases	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Proton glutamate symport protein	0	DIRECT
SpoIIaa-like	0	DIRECT
PGBD-like	0	DIRECT
Smc hinge domain	0	DIRECT
Flavoproteins	0	DIRECT
MgtE membrane domain-like	0	DIRECT
Rudiment single hybrid motif	0	DIRECT
SNARE-like	0	DIRECT
Myosin rod fragments	0	DIRECT
Ypt/Rab-GAP domain of gyp1p	0	DIRECT
Actin depolymerizing proteins	0	DIRECT
SCP-like	0	DIRECT
BAR/IMD domain-like	0	DIRECT
Alkaline phosphatase-like	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
Actin-crosslinking proteins	0	DIRECT
p53-like transcription factors	0	DIRECT
HIT/MYND zinc finger-like	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
SAP domain	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
Protease propeptides/inhibitors	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
SH3-domain	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
Ammonium transporter	0	DIRECT
TIMP-like	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
Phosphoglycerate mutase-like	0	DIRECT
Acyl-CoA dehydrogenase C-terminal domain-like	0	DIRECT
Aminomethyltransferase beta-barrel domain	0	DIRECT
Pectin lyase-like	0	DIRECT
ADP-ribosylation	0	DIRECT
Periplasmic binding protein-like II	0	DIRECT
GHMP Kinase, C-terminal domain	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
Calcium ATPase, transduction domain A	0	DIRECT
SNARE fusion complex	0	DIRECT
Zinc beta-ribbon	0	DIRECT
Hemopexin-like domain	0	DIRECT
Restriction endonuclease-like	0	DIRECT
cAMP-binding domain-like	0	DIRECT
CCCH zinc finger	0	DIRECT
Clavaminate synthase-like	0	DIRECT
Thioesterase/thiol ester dehydrase-isomerase	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
Aminoacid dehydrogenase-like, N-terminal domain	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
Putative DNA-binding domain	0	DIRECT
Metal cation-transporting ATPase, ATP-binding domain N	0	DIRECT
PP2C-like	0	DIRECT
Cyclin-like	0	DIRECT
Outer arm dynein light chain 1	0	DIRECT
NHL repeat	0	DIRECT
NTF2-like	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
Cystine-knot cytokines	0	DIRECT
Calcium-dependent phosphotriesterase	0	DIRECT
Adenine nucleotide alpha hydrolases-like	0	DIRECT
Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
MIR domain	0	DIRECT
ARM repeat	0	DIRECT
TAZ domain	0	DIRECT
NAD kinase/diacylglycerol kinase-like	0	DIRECT
SMR domain-like	0	DIRECT
Carbonic anhydrase	0	DIRECT
Phospholipase D/nuclease	0	DIRECT
Single hybrid motif	0	DIRECT
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0	DIRECT
SIS domain	0	DIRECT
Chitinase insertion domain	0	DIRECT
alpha-catenin/vinculin-like	0	DIRECT
Hect, E3 ligase catalytic domain	0	DIRECT
B-box zinc-binding domain	0	DIRECT
Serine protease inhibitors	0	DIRECT
Arginase/deacetylase	0	DIRECT
Ribokinase-like	0	DIRECT
Nucleotide-diphospho-sugar transferases	0	DIRECT
ABC transporter transmembrane region	0	DIRECT
Glycerol-3-phosphate (1)-acyltransferase	0	DIRECT
Tubulin nucleotide-binding domain-like	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
Acid proteases	0	DIRECT
Mob1/phocein	0	DIRECT
Spermadhesin, CUB domain	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
PHM/PNGase F	0	DIRECT
HD-domain/PDEase-like	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Osmotin, thaumatin-like protein	0	DIRECT
MIT domain	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
Protein kinase-like (PK-like)	0.1483	INHERITED FROM: muscle system physiology variant || muscle dystrophy || body muscle dystrophy
RNA-binding domain, RBD	0.3335	INHERITED FROM: sterile F1 || brood size variant
Nicotinic receptor ligand binding domain-like	0.406	INHERITED FROM: nervous system physiology variant || synaptic transmission variant
Neurotransmitter-gated ion-channel transmembrane pore	0.4602	INHERITED FROM: nervous system physiology variant || synaptic transmission variant
Ubiquitin-like	0.4998	INHERITED FROM: muscle system physiology variant || muscle dystrophy || body muscle dystrophy
FYVE/PHD zinc finger	0.6531	INHERITED FROM: transgenerational loss of fertility
PapD-like	0.7218	INHERITED FROM: sterile progeny
EF-hand	0.7789	INHERITED FROM: gonad sheath contractions variant || somatic gonad physiology variant || somatic sheath physiology variant
"Winged helix" DNA-binding domain	0.7921	INHERITED FROM: muscle system physiology variant || muscle dystrophy || brood size variant || body muscle dystrophy
WD40 repeat-like	0.8451	INHERITED FROM: brood size variant || reduced brood size
EGF/Laminin	0.8463	INHERITED FROM: nervous system physiology variant
P-loop containing nucleoside triphosphate hydrolases	0.8669	INHERITED FROM: postsynaptic region physiology variant || nervous system physiology variant || brood size variant
LDL receptor-like module	1	INHERITED FROM: fertilization defective

Family domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Clathrin adaptor core protein	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
PDEase	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase Pyr module	0	DIRECT
Tetramerization domain of potassium channels	0	DIRECT
PR-1-like	0	DIRECT
Class II glutamine amidotransferases	0	DIRECT
acyl-CoA oxidase N-terminal domains	0	DIRECT
UDPGT-like	0	DIRECT
Lipovitellin-phosvitin complex, superhelical domain	0	DIRECT
AN1-like Zinc finger	0	DIRECT
Cyclin	0	DIRECT
Regulator of chromosome condensation RCC1	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain	0	DIRECT
Dual specificity phosphatase-like	0	DIRECT
Tubulin, GTPase domain	0	DIRECT
SMAD MH1 domain	0	DIRECT
LysM domain	0	DIRECT
SAND domain	0	DIRECT
Prefoldin	0	DIRECT
CRAL/TRIO domain	0	DIRECT
Deoxycytidylate deaminase-like	0	DIRECT
Alcohol dehydrogenase-like, N-terminal domain	0	DIRECT
CalX-beta domain	0	DIRECT
RIO1-like kinases	0	DIRECT
Classic zinc finger, C2H2	0	DIRECT
Intermediate filament protein, coiled coil region	0	DIRECT
4HBT-like	0	DIRECT
Elafin-like	0	DIRECT
PaaI/YdiI-like	0	DIRECT
FYVE, a phosphatidylinositol-3-phosphate binding domain	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
Inositol polyphosphate kinase (IPK)	0	DIRECT
Ubiquitin activating enzymes (UBA)	0	DIRECT
ets domain	0	DIRECT
Epoxide hydrolase	0	DIRECT
Neurolysin-like	0	DIRECT
Osmotin, thaumatin-like protein	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
Proprotein convertase P-domain	0	DIRECT
Cytoplasmic domain of inward rectifier potassium channel	0	DIRECT
Type II chitinase	0	DIRECT
BAR domain	0	DIRECT
Histidine acid phosphatase	0	DIRECT
E2F dimerization segment	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
CoA-binding domain	0	DIRECT
Lactate & malate dehydrogenases, C-terminal domain	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Cadherin	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
Gamma-glutamyltranspeptidase-like	0	DIRECT
BC C-terminal domain-like	0	DIRECT
Arylsulfatase	0	DIRECT
Cation efflux protein transmembrane domain-like	0	DIRECT
Ras-binding domain, RBD	0	DIRECT
Spectrin repeat	0	DIRECT
Transcriptional factor domain	0	DIRECT
AraD-like aldolase/epimerase	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
BEACH domain	0	DIRECT
GHMP Kinase, N-terminal domain	0	DIRECT
Kinase associated domain 1, KA1	0	DIRECT
Proton glutamate symport protein	0	DIRECT
DPP6 catalytic domain-like	0	DIRECT
Sec63 N-terminal domain	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
RhoGDI-like	0	DIRECT
Sema domain	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	0	DIRECT
Chaperone J-domain	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
Inositol polyphosphate 5-phosphatase (IPP5)	0	DIRECT
FAD-linked reductases, N-terminal domain	0	DIRECT
Polypeptide N-acetylgalactosaminyltransferase 1, N-terminal domain	0	DIRECT
cAMP-binding domain	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Third domain of FERM	0	DIRECT
Acyl-carrier protein (ACP)	0	DIRECT
HSP20	0	DIRECT
Lesion bypass DNA polymerase (Y-family), catalytic domain	0	DIRECT
beta 1,4 galactosyltransferase (b4GalT1)	0	DIRECT
Pancreatic carboxypeptidases	0	DIRECT
Kix domain of CBP (creb binding protein)	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Complement control module/SCR domain	0	DIRECT
Autophagin-like	0	DIRECT
NLI interacting factor-like phosphatase	0	DIRECT
Calcium ATPase, transmembrane domain M	0	DIRECT
Pleckstrin-homology domain (PH domain)	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
CCCH zinc finger	0	DIRECT
DNA replication initiator (cdc21/cdc54) N-terminal domain	0	DIRECT
Fatty acid binding protein-like	0	DIRECT
TatD Mg-dependent DNase-like	0	DIRECT
Aquaporin-like	0	DIRECT
MFPT repeat	0	DIRECT
Carbonic anhydrase	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Group II chaperonin (CCT, TRIC), ATPase domain	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Cytochrome b5	0	DIRECT
Trunk domain of Sec23/24	0	DIRECT
Tropomyosin	0	DIRECT
Mo25 protein	0	DIRECT
WGR domain	0	DIRECT
Gelsolin-like	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
Galectin (animal S-lectin)	0	DIRECT
FtsH protease domain-like	0	DIRECT
Bactericidal permeability-increasing protein, BPI	0	DIRECT
N-acetylglucosaminyltransferase I	0	DIRECT
POU-specific domain	0	DIRECT
MIR domain	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
Purine and uridine phosphorylases	0	DIRECT
Carboxylesterase	0	DIRECT
Myb/SANT domain	0	DIRECT
Hydantoinase (dihydropyrimidinase), catalytic domain	0	DIRECT
6-phosphogluconate dehydrogenase-like, N-terminal domain	0	DIRECT
Pancreatic carboxypeptidase, activation domain	0	DIRECT
Chitinase insertion domain	0	DIRECT
Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
Elongation factors	0	DIRECT
PLC-like (P variant)	0	DIRECT
Cell cycle control phosphatase, catalytic domain	0	DIRECT
beta-CASP RNA-metabolising hydrolases	0	DIRECT
Calpain large subunit, catalytic domain (domain II)	0	DIRECT
RNA-polymerase beta-prime	0	DIRECT
alpha-mannosidase	0	DIRECT
Class I alpha-1;2-mannosidase, catalytic domain	0	DIRECT
CoA transferase alpha subunit-like	0	DIRECT
Ammonium transporter	0	DIRECT
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain	0	DIRECT
STAR domain	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
SAP domain	0	DIRECT
Hedgehog C-terminal (Hog) autoprocessing domain	0	DIRECT
Zf-UBP	0	DIRECT
Phoshoinositide 3-kinase (PI3K), catalytic domain	0	DIRECT
ABC transporter transmembrane region	0	DIRECT
Integrin domains	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
Polo-box duplicated region	0	DIRECT
Histone lysine methyltransferases	0	DIRECT
Aminoacid dehydrogenase-like, C-terminal domain	0	DIRECT
Phosphoribosyltransferases (PRTases)	0	DIRECT
SAM (sterile alpha motif) domain	0	DIRECT
Poly(A) polymerase, PAP, N-terminal domain	0	DIRECT
Clathrin coat assembly domain	0	DIRECT
Chromo domain	0	DIRECT
MATH domain	0	DIRECT
eIF1-like	0	DIRECT
Smc hinge domain	0	DIRECT
Glycerophosphoryl diester phosphodiesterase	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
BSD domain	0	DIRECT
Calpain large subunit, middle domain (domain III)	0	DIRECT
NOL1/NOP2/sun	0	DIRECT
Reductases	0	DIRECT
Ribosomal protein L1	0	DIRECT
NADPH-cytochrome p450 reductase-like	0	DIRECT
NHL repeat	0	DIRECT
beta-glycanases	0	DIRECT
Frizzled cysteine-rich domain	0	DIRECT
XPF/Rad1/Mus81 nuclease	0	DIRECT
Apyrase	0	DIRECT
Aldo-keto reductases (NADP)	0	DIRECT
Cystathionine synthase-like	0	DIRECT
Ribokinase-like	0	DIRECT
Bacterial dinuclear zinc exopeptidases	0	DIRECT
Reprolysin-like	0	DIRECT
Pepsin-like	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Mitochondrial carrier	0	DIRECT
Adenosine/AMP deaminase	0	DIRECT
RNA methyltransferase FtsJ	0	DIRECT
Glycerol-3-phosphate transporter	0	DIRECT
GYF domain	0	DIRECT
Filamin repeat (rod domain)	0	DIRECT
Nop domain	0	DIRECT
Acireductone dioxygenase	0	DIRECT
AlkB-like	0	DIRECT
alpha-catenin/vinculin	0	DIRECT
Purple acid phosphatase-like	0	DIRECT
GAPDH-like	0	DIRECT
Poly(A) polymerase, PAP, middle domain	0	DIRECT
Cytidylyltransferase	0	DIRECT
MutT-like	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
Ephrin ectodomain	0	DIRECT
Annexin	0	DIRECT
Hemocyanin middle domain	0	DIRECT
FCH domain	0	DIRECT
ZZ domain	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
Patatin	0	DIRECT
Anticodon-binding domain of Class II aaRS	0	DIRECT
ARID domain	0	DIRECT
Transcription factor IIA (TFIIA), alpha-helical domain	0	DIRECT
FF domain	0	DIRECT
Serpins	0	DIRECT
Serum paraoxonase/arylesterase 1, PON1	0	DIRECT
Hermes transposase-like	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
Translation initiation factor eIF4e	0	DIRECT
FHA domain	0	DIRECT
Crotonase-like	0	DIRECT
Myosin rod fragments	0	DIRECT
Astacin	0	DIRECT
Caspase catalytic domain	0	DIRECT
Oxysterol-binding protein	0	DIRECT
Hemopexin-like domain	0	DIRECT
HCDH C-domain-like	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
PDI-like	0	DIRECT
BC N-terminal domain-like	0	DIRECT
Calcium ATPase, transduction domain A	0	DIRECT
14-3-3 protein	0	DIRECT
YbiA-like	0	DIRECT
Pyk2-associated protein beta ARF-GAP domain	0	DIRECT
Phoshoinositide 3-kinase (PI3K) helical domain	0	DIRECT
RecA protein-like (ATPase-domain)	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
DEATH domain, DD	0	DIRECT
HAT/Suf repeat	0	DIRECT
Purple acid phosphatase, N-terminal domain	0	DIRECT
Methionine aminopeptidase, insert domain	0	DIRECT
Ras GEF	0	DIRECT
Thiolase-related	0	DIRECT
Cofilin-like	0	DIRECT
D-aminoacid oxidase, N-terminal domain	0	DIRECT
BTB/POZ domain	0	DIRECT
MIF-related	0	DIRECT
Smr domain	0	DIRECT
t-snare proteins	0	DIRECT
Dimeric isocitrate & isopropylmalate dehydrogenases	0	DIRECT
PP2C-like	0	DIRECT
Heme-dependent catalases	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
Doublecortin (DC)	0	DIRECT
Translational machinery components	0	DIRECT
Group II chaperonin (CCT, TRIC), apical domain	0	DIRECT
H-NOX domain	0	DIRECT
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains	0	DIRECT
SWIRM domain	0	DIRECT
Proteasome subunits	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
Ribonucleotide reductase-like	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
Ankyrin repeat	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
MIT domain	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Hydantoinase (dihydropyrimidinase)	0	DIRECT
Ferredoxin reductase FAD-binding domain-like	0	DIRECT
Small Kunitz-type inhibitors & BPTI-like toxins	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Fibronectin type III	0	DIRECT
Class I aldolase	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
Second domain of FERM	0	DIRECT
BolA-like	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
1,3-glucuronyltransferase	0	DIRECT
Tim10/DDP	0	DIRECT
5' to 3' exonuclease catalytic domain	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
Meta-cation ATPase, catalytic domain P	0	DIRECT
GAS2 domain	0	DIRECT
Phoshatidylinositol transfer protein, PITP	0	DIRECT
NagD-like	0	DIRECT
Rhomboid-like	0	DIRECT
RNA editing terminal uridyl transferase 2, RET2, domain 2	0	DIRECT
Peptidylglycine alpha-hydroxylating monooxygenase, PHM	0	DIRECT
Roadblock/LC7 domain	0	DIRECT
SNF-like	0	DIRECT
N-acetyl transferase, NAT	0	DIRECT
alpha-Amylases, C-terminal beta-sheet domain	0	DIRECT
BC ATP-binding domain-like	0	DIRECT
L-aminoacid/polyamine oxidase	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
EF-G/eEF-2 domains III and V	0	DIRECT
L-arabinose binding protein-like	0	DIRECT
Phosphotyrosine-binding domain (PTB)	0	DIRECT
Cdc48 N-terminal domain-like	0	DIRECT
Aminomethyltransferase beta-barrel domain	0	DIRECT
ATP-dependent protease Lon (La), catalytic domain	0	DIRECT
Neutral endopeptidase (neprilysin)	0	DIRECT
PABC (PABP) domain	0	DIRECT
Gastric lipase	0	DIRECT
Choline kinase	0	DIRECT
Synaptotagmin-like (S variant)	0	DIRECT
Hect, E3 ligase catalytic domain	0	DIRECT
Plexin repeat	0	DIRECT
Carboxypeptidase regulatory domain	0	DIRECT
Actin/HSP70	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase PP module	0	DIRECT
La domain	0	DIRECT
Transforming growth factor (TGF)-beta	0	DIRECT
DEP domain	0	DIRECT
Guanido kinase catalytic domain	0	DIRECT
Cell cycle transcription factor e2f-dp	0	DIRECT
Nucleotide and nucleoside kinases	0	DIRECT
B-box zinc-binding domain	0	DIRECT
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)	0	DIRECT
Arfaptin, Rac-binding fragment	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
Pseudouridine synthase I TruA	0	DIRECT
Alcohol dehydrogenase-like, C-terminal domain	0	DIRECT
YicI catalytic domain-like	0	DIRECT
Rv2717c-like	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
Clc chloride channel	0	DIRECT
Cyclophilin (peptidylprolyl isomerase)	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
UDP-glucose pyrophosphorylase	0	DIRECT
Serine carboxypeptidase-like	0	DIRECT
TBP-associated factors, TAFs	0	DIRECT
Extended PAW domain	0	DIRECT
RNA-polymerase beta	0	DIRECT
PDZ domain	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
RING finger domain, C3HC4	0	DIRECT
Ribosomal protein L18 and S11	0	DIRECT
Arylamine N-methyltransferase	0	DIRECT
Ypt/Rab-GAP domain of gyp1p	0	DIRECT
Armadillo repeat	0	DIRECT
Papain-like	0	DIRECT
Aminomethyltransferase folate-binding domain	0	DIRECT
Acyl-CoA thioesterase	0	DIRECT
SMAD domain	0	DIRECT
Ferredoxin domains from multidomain proteins	0	DIRECT
Ngr ectodomain-like	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
Bacterial lipase	0	DIRECT
L30e/L7ae ribosomal proteins	0	DIRECT
Mammalian PLC	0	DIRECT
Band 7/SPFH domain	0	DIRECT
Ribosomal protein S10	0	DIRECT
alpha-mannosidase, domain 2	0	DIRECT
Ribosomal protein S18	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
LDH N-terminal domain-like	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
28-residue LRR	0	DIRECT
ATI-like	0	DIRECT
Leukotriene A4 hydrolase catalytic domain	0	DIRECT
Kelch motif	0	DIRECT
Biotin dependent carboxylase carboxyltransferase domain	0	DIRECT
Protein prenyltransferases	0	DIRECT
NTF2-like	0	DIRECT
Hormone receptor domain	0	DIRECT
Hsp90 middle domain	0	DIRECT
Ribonuclease PH domain 1-like	0	DIRECT
Biotinyl/lipoyl-carrier proteins and domains	0	DIRECT
Cold shock DNA-binding domain-like	0	DIRECT
Class I glutamine amidotransferases (GAT)	0	DIRECT
Pumilio repeat	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
CBS-domain pair	0	DIRECT
CO dehydrogenase flavoprotein N-terminal domain-like	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
Histone deacetylase, HDAC	0	DIRECT
Protein serine/threonine phosphatase	0	DIRECT
Tudor domain	0	DIRECT
Erythroid transcription factor GATA-1	0	DIRECT
TAZ domain	0	DIRECT
Neurotransmitter-gated ion-channel transmembrane pore	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Myotubularin-like phosphatases	0	DIRECT
Myeloperoxidase-like	0	DIRECT
AAT-like	0	DIRECT
SH3-domain	0	DIRECT
Spermadhesin, CUB domain	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
Arginine methyltransferase	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
UBA domain	0	DIRECT
PX domain	0	DIRECT
WWE domain	0	DIRECT
beta-Lactamase/D-ala carboxypeptidase	0	DIRECT
Cap-Gly domain	0	DIRECT
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta	0	DIRECT
Ribonuclease H	0	DIRECT
Amylase, catalytic domain	0	DIRECT
Nitrogenase iron protein-like	0	DIRECT
HD domain	0	DIRECT
Matrix metalloproteases, catalytic domain	0	DIRECT
Double-stranded RNA-binding domain (dsRBD)	0	DIRECT
FAD/NAD-linked reductases, N-terminal and central domains	0	DIRECT
Transcription factor IIA (TFIIA), beta-barrel domain	0	DIRECT
YihX-like	0	DIRECT
U-box	0	DIRECT
Trehalase-like	0	DIRECT
Laminin G-like module	0	DIRECT
First domain of FERM	0	DIRECT
Formin homology 2 domain (FH2 domain)	0	DIRECT
Small-conductance potassium channel	0	DIRECT
2Fe-2S ferredoxin domains from multidomain proteins	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
alpha-mannosidase, C-terminal domain	0	DIRECT
HEAT repeat	0	DIRECT
p120GAP domain-like	0	DIRECT
Sterol carrier protein, SCP	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	0	DIRECT
UBC-related	0	DIRECT
Adenain-like	0	DIRECT
Linker histone H1/H5	0	DIRECT
PAZ domain	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Eukaryotic type KH-domain (KH-domain type I)	0	DIRECT
N-type ATP pyrophosphatases	0	DIRECT
Subtilases	0	DIRECT
NADPH-cytochrome p450 reductase FAD-binding domain-like	0	DIRECT
Phosphatidylethanolamine binding protein	0	DIRECT
UBX domain	0	DIRECT
D-aminoacid oxidase-like	0	DIRECT
Acylamino-acid-releasing enzyme, C-terminal donain	0	DIRECT
SNARE fusion complex	0	DIRECT
Glutamine synthetase catalytic domain	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
VHS domain	0	DIRECT
Integrin A (or I) domain	0	DIRECT
Formate/glycerate dehydrogenases, NAD-domain	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
T-box	0	DIRECT
WW domain	0	DIRECT
acyl-CoA oxidase C-terminal domains	0	DIRECT
Multidomain sulfurtransferase (rhodanese)	0	DIRECT
RUN domain	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
MPP-like	0	DIRECT
PhyH-like	0	DIRECT
COMT-like	0	DIRECT
Sm motif of small nuclear ribonucleoproteins, SNRNP	0	DIRECT
PhzC/PhzF-like	0	DIRECT
Inositol monophosphatase/fructose-1,6-bisphosphatase-like	0	DIRECT
Sec63 C-terminal domain-like	0	DIRECT
Calmodulin-like	0	DIRECT
CAT-like	0	DIRECT
Single strand DNA-binding domain, SSB	0	DIRECT
Tubulin, C-terminal domain	0	DIRECT
IF2B-like	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
I set domains	0	DIRECT
Poly(A) polymerase, PAP, C-terminal domain	0	DIRECT
Ubiquitin-related	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
Poly(ADP-ribose) polymerase, C-terminal domain	0	DIRECT
Ganglioside M2 (gm2) activator	0	DIRECT
Lipovitellin-phosvitin complex; beta-sheet shell regions	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Higher-molecular-weight phosphotyrosine protein phosphatases	0	DIRECT
Glutaminase	0	DIRECT
Anticodon-binding domain	0	DIRECT
AMPK-beta glycogen binding domain-like	0	DIRECT
Laminin-type module	0	DIRECT
Metal cation-transporting ATPase, ATP-binding domain N	0	DIRECT
MIF4G domain-like	0	DIRECT
ALDH-like	0	DIRECT
Family 19 glycosidase	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
CUT domain	0	DIRECT
HMG-box	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Choline/Carnitine O-acyltransferase	0	DIRECT
Bromodomain	0	DIRECT
PEP carboxykinase C-terminal domain	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
Glycerol kinase	0	DIRECT
Rap/Ran-GAP	0	DIRECT
Paired domain	0	DIRECT
Calponin-homology domain, CH-domain	0	DIRECT
GABA-aminotransferase-like	0	DIRECT
Adenylyl and guanylyl cyclase catalytic domain	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
L domain	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
Fungal lipases	0	DIRECT
Mob1/phocein	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
Catalytic, N-terminal domain of histone methyltransferase Dot1l	0	DIRECT
F-box domain	0	DIRECT
LEM domain	0	DIRECT
Acetylcholinesterase-like	0	DIRECT
SPRY domain	0	DIRECT
Glycogenin	0	DIRECT
Ricin B-like	0	DIRECT
LacY-like proton/sugar symporter	0	DIRECT
Eps15 homology domain (EH domain)	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
LIM domain	0	DIRECT
Citrate synthase	0	DIRECT
EF-hand modules in multidomain proteins	0	DIRECT
Pyridoxal-dependent decarboxylase	0	DIRECT
Phosphate binding protein-like	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
SH2 domain	0	DIRECT
Internalin LRR domain	0	DIRECT
PUA domain	0	DIRECT
Hexokinase	0	DIRECT
Tetraspanin	0	DIRECT
Diap1 N-terninal region-like	0	DIRECT
Sec7 domain	0	DIRECT
Sir2 family of transcriptional regulators	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Troponin I	0	DIRECT
Protein kinases, catalytic subunit	0.08611	INHERITED FROM: muscle system physiology variant || muscle dystrophy || body muscle dystrophy || sterile progeny
C-type lectin domain	0.3068	INHERITED FROM: sterile progeny
Canonical RBD	0.3693	INHERITED FROM: sterile F1 || brood size variant
Nicotinic receptor ligand binding domain-like	0.4003	INHERITED FROM: nervous system physiology variant || synaptic transmission variant
Tandem AAA-ATPase domain	0.4458	INHERITED FROM: male sterile || male fertility reduced || male fertility variant
G proteins	0.5059	INHERITED FROM: postsynaptic region physiology variant || nervous system physiology variant || synaptic transmission variant
MSP-like	0.64	INHERITED FROM: sterile progeny
WD40-repeat	0.9395	INHERITED FROM: dead eggs laid || brood size variant || reduced brood size
LDL receptor-like module	0.9635	INHERITED FROM: fertilization defective