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Worm Phenotype (WP): organism physiology variant

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Variant [WBPhenotype:0000886] <5>
+ 1:   physiology variant [WBPhenotype:0000519] <7>(494|573) (495|248|68)
0:   organism physiology variant [WBPhenotype:0000576] <10>(354|423) (357|200|60)
- 1:   organism homeostasis metabolism variant [WBPhenotype:0000577] <17>(343|412) (348|198|59)
- 1:   dauer arrest variant [WBPhenotype:0000159] <6>(9|11) (10|5|0)
- 1:   life span variant [WBPhenotype:0000039] <6>(26|32) (27|14|3)
- 1:   aging variant [WBPhenotype:0001739] <4>(1|0) (1|0|0)
- 1:   genetic pathway variant [WBPhenotype:0000074] <2>(0|0) (0|0|0)
- 1:   sexually dimorphic physiology variant [WBPhenotype:0000889] <2>(1|1) (1|0|0)
- 1:   heteroplasmy [WBPhenotype:0002121] <1>(2|1) (2|1|0)
- 1:   growth defective on low phosphate media [WBPhenotype:0002235](0|0) (0|0|0)
- 1:   larval physiology variant [WBPhenotype:0001293](0|0) (0|0|0)
- 1:   subviable [WBPhenotype:0002116](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
Hormone receptor domain0Direct
Spectrin repeat0Direct
PLP-binding barrel0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Acyl-CoA dehydrogenase NM domain-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Bacterial exopeptidase dimerisation domain0Direct
Carbohydrate phosphatase0Direct
Oxysterol-binding protein-like0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
WWE domain0Direct
Acid phosphatase/Vanadium-dependent haloperoxidase0Direct
Single hybrid motif0Direct
t-snare proteins0Direct
Cullin repeat-like0Direct
LDH C-terminal domain-like0Direct
Acyl-CoA dehydrogenase C-terminal domain-like0Direct
Ribulose-phoshate binding barrel0Direct
Clc chloride channel0Direct
PHM/PNGase F0Direct
cAMP-binding domain-like0Direct
SPOC domain-like0Direct
MFPT repeat-like0Direct
MgtE membrane domain-like0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
Nop domain0Direct
14-3-3 protein0Direct
Nucleoporin domain0Direct
Band 7/SPFH domain0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Annexin0Direct
Cullin homology domain0Direct
Ribosomal L27 protein-like0Direct
Class II aaRS ABD-related0Direct
GYF domain0Direct
CBD9-like0Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
Tim10-like0Direct
F1F0 ATP synthase subunit C0Direct
Transducin (heterotrimeric G protein), gamma chain0Direct
Helical domain of Sec23/240Direct
PYP-like sensor domain (PAS domain)0Direct
TGS-like0Direct
Sec7 domain0Direct
Class I glutamine amidotransferase-like0Direct
LysM domain0Direct
HSP40/DnaJ peptide-binding domain0Direct
GAS2 domain-like0Direct
Glycolipid transfer protein, GLTP0Direct
ThrRS/AlaRS common domain0Direct
Polo-box domain0Direct
Intermediate filament protein, coiled coil region0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
Succinyl-CoA synthetase domains0Direct
Restriction endonuclease-like0Direct
PUA domain-like0Direct
Cadherin-like0Direct
Invertebrate chitin-binding proteins0Direct
Purine and uridine phosphorylases0Direct
PurM C-terminal domain-like0Direct
TK C-terminal domain-like0Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Insulin-like0Direct
3-carboxy-cis,cis-mucoante lactonizing enzyme0Direct
S-adenosylmethionine synthetase0Direct
Ribosomal protein S100Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0Direct
Complement control module/SCR domain0Direct
YWTD domain0Direct
Rap/Ran-GAP0Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0Direct
Proton glutamate symport protein0Direct
R3H domain0Direct
Zn-finger domain of Sec23/240Direct
Surp module (SWAP domain)0Direct
GroEL-intermediate domain like0Direct
PEBP-like0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
Carbon-nitrogen hydrolase0Direct
ALDH-like0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Actin-like ATPase domain0Direct
Integrin alpha N-terminal domain0Direct
SAICAR synthase-like0Direct
GroEL apical domain-like0Direct
eIF4e-like0Direct
Outer arm dynein light chain 10Direct
FF domain0Direct
PEP carboxykinase-like0Direct
Cytochrome c0Direct
Skp1 dimerisation domain-like0Direct
Protease propeptides/inhibitors0Direct
Periplasmic binding protein-like II0Direct
Rudiment single hybrid motif0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Nucleotidyltransferase0Direct
VPS9 domain0Direct
beta-lactamase/transpeptidase-like0Direct
SMAD MH1 domain0Direct
PK beta-barrel domain-like0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
Carboxypeptidase regulatory domain-like0Direct
GroEL equatorial domain-like0Direct
FtsH protease domain-like0Direct
Citrate synthase0Direct
Creatinase/prolidase N-terminal domain0Direct
Second domain of FERM0Direct
PAP/OAS1 substrate-binding domain0Direct
Sec63 N-terminal domain-like0Direct
HSP90 C-terminal domain0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
SAND domain-like0Direct
Ribosomal protein L10Direct
ARID-like0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Troponin coil-coiled subunits0Direct
Translational machinery components0Direct
PIN domain-like0Direct
Lamin A/C globular tail domain0Direct
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase0Direct
Diaminopimelate epimerase-like0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
YbiA-like0Direct
Blood coagulation inhibitor (disintegrin)0Direct
Hedgehog/intein (Hint) domain0Direct
Zn-binding ribosomal proteins0Direct
PAP/Archaeal CCA-adding enzyme, C-terminal domain0Direct
Chaperone J-domain0Direct
Hypothetical protein c14orf129, hspc2100Direct
AN1-like Zinc finger0Direct
Composite domain of metallo-dependent hydrolases0Direct
Lipovitellin-phosvitin complex, superhelical domain0Direct
Tubulin C-terminal domain-like0Direct
Smc hinge domain0Direct
Tubulin nucleotide-binding domain-like0Direct
Transducin (alpha subunit), insertion domain0Direct
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)0Direct
Nucleoside diphosphate kinase, NDK0Direct
HCP-like0Direct
Galactose oxidase, central domain0Direct
JAB1/MPN domain0Direct
Ribosomal protein L10-like0Direct
Arginase/deacetylase0Direct
FAD-dependent thiol oxidase0Direct
Terpenoid synthases0Direct
CAD & PB1 domains0Direct
L30e-like0Direct
Clathrin adaptor appendage domain0Direct
CRAL/TRIO N-terminal domain0Direct
Ribokinase-like0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
Elafin-like0Direct
Cation efflux protein cytoplasmic domain-like0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Integrin domains0Direct
SCP-like0Direct
Chitinase insertion domain0Direct
Cystatin/monellin0Direct
PEP carboxykinase N-terminal domain0Direct
ENTH/VHS domain0Direct
Heme-dependent catalase-like0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Tricorn protease domain 20Direct
Galactose mutarotase-like0Direct
Activating enzymes of the ubiquitin-like proteins0Direct
Thyroglobulin type-1 domain0Direct
HSP20-like chaperones0Direct
Cdc48 domain 2-like0Direct
Phosphoenolpyruvate/pyruvate domain0Direct
dsRNA-binding domain-like0Direct
Heme-dependent peroxidases0Direct
SWIB/MDM2 domain0Direct
RBP11-like subunits of RNA polymerase0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Glutathione synthetase ATP-binding domain-like0Direct
ADP-ribosylation0Direct
MOSC N-terminal domain-like0Direct
BEACH domain0Direct
Cu,Zn superoxide dismutase-like0Direct
Small-conductance potassium channel0Direct
Type II DNA topoisomerase0Direct
alpha/beta knot0Direct
GAT-like domain0Direct
Aldolase0Direct
Formate/glycerate dehydrogenase catalytic domain-like0Direct
LEM domain0Direct
Kringle-like0Direct
MIR domain0Direct
lambda repressor-like DNA-binding domains0Direct
DEATH domain0Direct
ArfGap/RecO-like zinc finger0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Tubby C-terminal domain-like0Direct
Phosphoglucomutase, first 3 domains0Direct
Carbonic anhydrase0Direct
Domain of poly(ADP-ribose) polymerase0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Mitochondrial carrier0Direct
Fibrinogen C-terminal domain-like0Direct
Families 57/38 glycoside transferase middle domain0Direct
Ran binding protein zinc finger-like0Direct
Radical SAM enzymes0Direct
GroES-like0Direct
Chromo domain-like0Direct
Putative DNA-binding domain0Direct
Phoshotransferase/anion transport protein0Direct
PLC-like phosphodiesterases0Direct
Ribosomal proteins S24e, L23 and L15e0Direct
Sec1/munc18-like (SM) proteins0Direct
Subtilisin-like0Direct
Doublecortin (DC)0Direct
Pepsin inhibitor-30Direct
CO dehydrogenase ISP C-domain like0Direct
PABC (PABP) domain0Direct
SIS domain0Direct
2Fe-2S ferredoxin-like0Direct
Profilin (actin-binding protein)0Direct
Pentein0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Phosphoglucomutase, C-terminal domain0Direct
Molybdenum cofactor-binding domain0Direct
Terpenoid cyclases/Protein prenyltransferases0Direct
DNA repair protein MutS, domain III0Direct
Aquaporin-like0Direct
Thiolase-like0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
L-aspartase-like0Direct
alpha-catenin/vinculin-like0Direct
Ferritin-like0Direct
PreATP-grasp domain0Direct
PGBD-like0Direct
ISP domain0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
PurM N-terminal domain-like0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
WGR domain-like0Direct
P-loop containing nucleoside triphosphate hydrolases0.0000001606Direct
PH domain-like0.00005362Direct
Histone-fold0.0001355Direct
Protein kinase-like (PK-like)0.004247Inherited
TPR-like0.01999Inherited
Periplasmic binding protein-like I0.02009Inherited
PapD-like0.02945Inherited
ARM repeat0.03947Inherited
SH2 domain0.04603Inherited
"Winged helix" DNA-binding domain0.04806Inherited
PDZ domain-like0.05399Inherited
Homeodomain-like0.05676Inherited
WD40 repeat-like0.06737Inherited
Nucleic acid-binding proteins0.06821Inherited
Acetyl-CoA synthetase-like0.07031Inherited
Cyclin-like0.07776Inherited
CCCH zinc finger0.08604Inherited
EGF/Laminin0.08699Inherited
Translation proteins0.1054Inherited
Galactose-binding domain-like0.1093Inherited
Nucleotide cyclase0.1288Inherited
HLH, helix-loop-helix DNA-binding domain0.1288Inherited
Acid proteases0.1291Inherited
SMAD/FHA domain0.1291Inherited
Calcium ATPase, transmembrane domain M0.1428Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.1578Inherited
Regulator of G-protein signaling, RGS0.1578Inherited
SH3-domain0.1682Inherited
E set domains0.1709Inherited
Calcium ATPase, transduction domain A0.1748Inherited
Quinoprotein alcohol dehydrogenase-like0.1932Inherited
Ankyrin repeat0.2048Inherited
Multidrug efflux transporter AcrB transmembrane domain0.2081Inherited
DBL homology domain (DH-domain)0.2129Inherited
HMG-box0.235Inherited
ClpP/crotonase0.235Inherited
Cytochrome P4500.2364Inherited
(Trans)glycosidases0.2364Inherited
POZ domain0.2767Inherited
Bromodomain0.2854Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.2854Inherited
RNA-binding domain, RBD0.2867Inherited
Cysteine proteinases0.2916Inherited
RNI-like0.3025Inherited
SNARE-like0.3135Inherited
ABC transporter transmembrane region0.3161Inherited
Lipocalins0.3253Inherited
Translation proteins SH3-like domain0.3798Inherited
Cation efflux protein transmembrane domain-like0.3798Inherited
Nicotinic receptor ligand binding domain-like0.3921Inherited
Ubiquitin-like0.4089Inherited
Cysteine-rich domain0.423Inherited
FKBP-like0.429Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.4299Inherited
Class II aaRS and biotin synthetases0.4882Inherited
DHS-like NAD/FAD-binding domain0.5016Inherited
PRTase-like0.5016Inherited
Hect, E3 ligase catalytic domain0.5016Inherited
Myosin rod fragments0.5016Inherited
BRCT domain0.5231Inherited
FYVE/PHD zinc finger0.5422Inherited
Ribosomal protein S5 domain 2-like0.5456Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.5511Inherited
Calpain large subunit, middle domain (domain III)0.5511Inherited
Riboflavin synthase domain-like0.5511Inherited
Sm-like ribonucleoproteins0.5548Inherited
WW domain0.5548Inherited
FAD-linked reductases, C-terminal domain0.5548Inherited
Cystine-knot cytokines0.5548Inherited
Voltage-gated potassium channels0.559Inherited
Nucleotidylyl transferase0.579Inherited
FAD/NAD(P)-binding domain0.5823Inherited
SET domain0.5911Inherited
Seven-hairpin glycosidases0.6011Inherited
SAM/Pointed domain0.604Inherited
UBC-like0.6153Inherited
Multidrug resistance efflux transporter EmrE0.6221Inherited
HAD-like0.6294Inherited
Osmotin, thaumatin-like protein0.658Inherited
KA1-like0.658Inherited
Nucleotide-binding domain0.658Inherited
MFS general substrate transporter0.6887Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.6891Inherited
GST C-terminal domain-like0.712Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.7169Inherited
4Fe-4S ferredoxins0.7196Inherited
S15/NS1 RNA-binding domain0.7196Inherited
Frizzled cysteine-rich domain0.7196Inherited
Ribonuclease H-like0.7509Inherited
PAZ domain0.7644Inherited
MIT domain0.7863Inherited
ADC-like0.7863Inherited
alpha/beta-Hydrolases0.82Inherited
Fibronectin type III0.8262Inherited
Clavaminate synthase-like0.8607Inherited
EF-hand0.8649Inherited
Leucine zipper domain0.8735Inherited
GTPase activation domain, GAP0.8822Inherited
UBA-like0.8849Inherited
DNA/RNA polymerases0.9468Inherited
p53-like transcription factors0.9517Inherited
Ribonuclease PH domain 2-like0.9623Inherited
Thioredoxin-like0.9729Inherited
Immunoglobulin0.973Inherited
Nuclear receptor ligand-binding domain0.9837Inherited
Eukaryotic type KH-domain (KH-domain type I)1Inherited
beta-beta-alpha zinc fingers1Inherited
Cyclophilin-like1Inherited
Saposin1Inherited
Bet v1-like1Inherited
CoA-dependent acyltransferases1Inherited
Ligand-binding domain in the NO signalling and Golgi transport1Inherited
RING/U-box1Inherited
Family A G protein-coupled receptor-like1Inherited
B-box zinc-binding domain1Inherited
F-box domain1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Clathrin coat assembly domain0Direct
Oxysterol-binding protein0Direct
Peptidylglycine alpha-hydroxylating monooxygenase, PHM0Direct
POU-specific domain0Direct
Translation initiation factor eIF4e0Direct
Cullin repeat0Direct
Chaperone J-domain0Direct
Hydantoinase (dihydropyrimidinase)0Direct
YihX-like0Direct
WWE domain0Direct
AAT-like0Direct
Methionine aminopeptidase, insert domain0Direct
Trunk domain of Sec23/240Direct
Chitinase insertion domain0Direct
Small-conductance potassium channel0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
PurM C-terminal domain-like0Direct
Lamin A/C globular tail domain0Direct
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta0Direct
Profilin (actin-binding protein)0Direct
Acyl-carrier protein (ACP)0Direct
Acireductone dioxygenase0Direct
beta-sandwich domain of Sec23/240Direct
28-residue LRR0Direct
PEP carboxykinase N-terminal domain0Direct
Doublecortin (DC)0Direct
RecA protein-like (ATPase-domain)0Direct
Alcohol dehydrogenase-like, N-terminal domain0Direct
Translational machinery components0Direct
cAMP-binding domain0Direct
GAS2 domain0Direct
COMT-like0Direct
SWIRM domain0Direct
PDEase0Direct
Troponin I0Direct
Acyl-CoA thioesterase0Direct
MFPT repeat0Direct
Arylsulfatase0Direct
BEACH domain0Direct
Glycosyl transferases group 10Direct
BC C-terminal domain-like0Direct
LysM domain0Direct
DPP6 catalytic domain-like0Direct
Transducin (alpha subunit), insertion domain0Direct
HSP40/DnaJ peptide-binding domain0Direct
Brix domain0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Protein prenyltransferases0Direct
BC N-terminal domain-like0Direct
acyl-CoA oxidase C-terminal domains0Direct
Ribosomal protein L10Direct
VHS domain0Direct
Branched-chain alpha-keto acid dehydrogenase Pyr module0Direct
Helical domain of Sec23/240Direct
Sir2 family of transcriptional regulators0Direct
F1F0 ATP synthase subunit C0Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
Subtilases0Direct
Poly(ADP-ribose) polymerase, C-terminal domain0Direct
Poly(A) polymerase, PAP, C-terminal domain0Direct
Acylamino-acid-releasing enzyme, C-terminal donain0Direct
Transducin (heterotrimeric G protein), gamma chain0Direct
Third domain of FERM0Direct
Thyroglobulin type-1 domain0Direct
Double-stranded RNA-binding domain (dsRBD)0Direct
SMAD MH1 domain0Direct
Sterol carrier protein, SCP0Direct
Thiolase-related0Direct
Cell cycle control phosphatase, catalytic domain0Direct
Quinoprotein alcohol dehydrogenase-like0Direct
Inositol polyphosphate kinase (IPK)0Direct
GAPDH-like0Direct
PaaI/YdiI-like0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
14-3-3 protein0Direct
Hsp90 middle domain0Direct
Ribosomal protein L18 and S110Direct
t-snare proteins0Direct
Phosphatidylethanolamine binding protein0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
ALDH-like0Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0Direct
Nop domain0Direct
Succinyl-CoA synthetase domains0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Choline kinase0Direct
HEAT repeat0Direct
alpha-mannosidase, domain 20Direct
Laminin G-like module0Direct
DEP domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Ribokinase-like0Direct
BAR domain0Direct
Adenosine/AMP deaminase0Direct
D-aminoacid oxidase, N-terminal domain0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
a tRNA synthase domain0Direct
Glycogenin0Direct
RNA editing terminal uridyl transferase 2, RET2, domain 20Direct
Ngr ectodomain-like0Direct
Matrix metalloproteases, catalytic domain0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain0Direct
Biotinyl/lipoyl-carrier proteins and domains0Direct
Insulin-like0Direct
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain0Direct
L-aminoacid/polyamine oxidase0Direct
Group II chaperonin (CCT, TRIC), ATPase domain0Direct
Reprolysin-like0Direct
NHL repeat0Direct
Hedgehog C-terminal (Hog) autoprocessing domain0Direct
Second domain of FERM0Direct
Hydantoinase (dihydropyrimidinase), catalytic domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Formate/glycerate dehydrogenases, NAD-domain0Direct
Alcohol dehydrogenase-like, C-terminal domain0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Sec7 domain0Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0Direct
IF2B-like0Direct
FHA domain0Direct
Phosphoglucomutase, first 3 domains0Direct
AN1-like Zinc finger0Direct
Calpain large subunit, catalytic domain (domain II)0Direct
Citrate synthase0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Calcium ATPase, transmembrane domain M0Direct
FAD-dependent thiol oxidase0Direct
RhoGDI-like0Direct
Regulator of chromosome condensation RCC10Direct
Internalin LRR domain0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0Direct
Cdc48 domain 2-like0Direct
Ribonucleotide reductase-like0Direct
HSP200Direct
Domain of poly(ADP-ribose) polymerase0Direct
Tetraspanin0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
PDI-like0Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
Histone deacetylase, HDAC0Direct
Amylase, catalytic domain0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Erythroid transcription factor GATA-10Direct
NTF2-like0Direct
Ran binding protein zinc finger-like0Direct
Cyclin0Direct
PurM N-terminal domain-like0Direct
Polo-box duplicated region0Direct
beta 1,4 galactosyltransferase (b4GalT1)0Direct
Sec63 C-terminal domain-like0Direct
YbiA-like0Direct
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)0Direct
Single strand DNA-binding domain, SSB0Direct
Clc chloride channel0Direct
DNA repair protein MutS, domain III0Direct
HD domain0Direct
Surp module (SWAP domain)0Direct
Integrin domains0Direct
Type II DNA topoisomerase0Direct
RNA-polymerase beta-prime0Direct
CRAL/TRIO N-terminal domain0Direct
Skp1 dimerisation domain-like0Direct
Cadherin0Direct
Branched-chain alpha-keto acid dehydrogenase PP module0Direct
Class II glutamine amidotransferases0Direct
HSP90 C-terminal domain0Direct
Epoxide hydrolase0Direct
Tim10/DDP0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
Proteasome subunits0Direct
Blood coagulation inhibitor (disintegrin)0Direct
PEP carboxykinase C-terminal domain0Direct
EGF-type module0Direct
Poly(A) polymerase, PAP, N-terminal domain0Direct
2Fe-2S ferredoxin domains from multidomain proteins0Direct
Ribosomal protein S100Direct
Class I aldolase0Direct
Myeloperoxidase-like0Direct
5' to 3' exonuclease catalytic domain0Direct
Heme-dependent catalases0Direct
Anticodon-binding domain0Direct
Aquaporin-like0Direct
Mitochondrial carrier0Direct
XPF/Rad1/Mus81 nuclease0Direct
Ras-binding domain, RBD0Direct
Bactericidal permeability-increasing protein, BPI0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
LacY-like proton/sugar symporter0Direct
YicI catalytic domain-like0Direct
Proton glutamate symport protein0Direct
Purine and uridine phosphorylases0Direct
Phosphate binding protein-like0Direct
Nucleosome core histones0Direct
Carbonic anhydrase0Direct
Tubulin, C-terminal domain0Direct
Gamma-glutamyltranspeptidase-like0Direct
Lipovitellin-phosvitin complex, superhelical domain0Direct
Hexokinase0Direct
Proprotein convertase P-domain0Direct
Group II chaperonin (CCT, TRIC), apical domain0Direct
Annexin0Direct
Smc hinge domain0Direct
Adenain-like0Direct
Pyk2-associated protein beta ARF-GAP domain0Direct
SWIB/MDM2 domain0Direct
Hypothetical protein c14orf129, hspc2100Direct
LDH N-terminal domain-like0Direct
First domain of FERM0Direct
NOL1/NOP2/sun0Direct
WGR domain0Direct
1,3-glucuronyltransferase0Direct
Glutaminase0Direct
Biotin dependent carboxylase carboxyltransferase domain0Direct
DNA gyrase/MutL, second domain0Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0Direct
Actin/HSP700Direct
Reductases0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Class I glutamine amidotransferases (GAT)0Direct
Glycerol kinase0Direct
Cullin homology domain0Direct
ets domain0Direct
Pancreatic carboxypeptidase, activation domain0Direct
Cofilin-like0Direct
SMAD domain0Direct
Fibrinogen C-terminal domain-like0Direct
Linker histone H1/H50Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
Chromo domain0Direct
Rap/Ran-GAP0Direct
RNA-polymerase beta0Direct
Anticodon-binding domain of Class II aaRS0Direct
Lactate & malate dehydrogenases, C-terminal domain0Direct
D-aminoacid oxidase-like0Direct
Sec63 N-terminal domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
AMPK-beta glycogen binding domain-like0Direct
Arginine methyltransferase0Direct
LEM domain0Direct
Aminoacid dehydrogenase-like, C-terminal domain0Direct
Intermediate filament protein, coiled coil region0Direct
Poly(A) polymerase, PAP, middle domain0Direct
Pancreatic carboxypeptidases0Direct
SAND domain0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
p120GAP domain-like0Direct
Lesion bypass DNA polymerase (Y-family), catalytic domain0Direct
S-adenosylmethionine synthetase0Direct
Hormone receptor domain0Direct
MIR domain0Direct
Phosphotyrosine-binding domain (PTB)0Direct
Complement control module/SCR domain0Direct
HAT/Suf repeat0Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
Glycolipid transfer protein, GLTP0Direct
Type II chitinase0Direct
beta-Lactamase/D-ala carboxypeptidase0Direct
HCDH C-domain-like0Direct
SAM (sterile alpha motif) domain0Direct
Myotubularin-like phosphatases0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
PABC (PABP) domain0Direct
Mammalian PLC0Direct
GYF domain0Direct
Clathrin adaptor core protein0Direct
La domain0Direct
Ubiquitin activating enzymes (UBA)0Direct
alpha-catenin/vinculin0Direct
Carboxypeptidase regulatory domain0Direct
DEATH domain, DD0Direct
Band 7/SPFH domain0Direct
CO dehydrogenase ISP C-domain like0Direct
Glycerophosphoryl diester phosphodiesterase0Direct
Sec1/munc18-like (SM) proteins0Direct
FF domain0Direct
Nucleoside diphosphate kinase, NDK0Direct
Cation efflux protein cytoplasmic domain-like0Direct
CoA-binding domain0Direct
Molybdenum cofactor-binding domain0Direct
alpha-mannosidase, C-terminal domain0Direct
CAT-like0Direct
PLC-like (P variant)0Direct
PhzC/PhzF-like0Direct
BC ATP-binding domain-like0Direct
alpha-mannosidase0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Tubulin, GTPase domain0Direct
UDP-glucose pyrophosphorylase0Direct
FtsH protease domain-like0Direct
Fatty acid binding protein-like0Direct
SCF ubiquitin ligase complex WHB domain0Direct
U-box0Direct
MOSC N-terminal domain-like0Direct
Regulator of G-protein signaling, RGS0Direct
Pepsin inhibitor-30Direct
Spectrin repeat0Direct
MIF4G domain-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
MutT-like0Direct
Elafin-like0Direct
Filamin repeat (rod domain)0Direct
Inositol monophosphatase/fructose-1,6-bisphosphatase-like0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain0Direct
L30e/L7ae ribosomal proteins0Direct
Cu,Zn superoxide dismutase-like0Direct
Phosphoribosyltransferases (PRTases)0Direct
ATP-dependent protease Lon (La), catalytic domain0Direct
YWTD domain0Direct
Dual specificity phosphatase-like0Direct
Cytoplasmic domain of inward rectifier potassium channel0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Bacterial exopeptidase dimerisation domain0Direct
Armadillo repeat0Direct
CUT domain0Direct
Paired domain0Direct
DPP6 N-terminal domain-like0Direct
CO dehydrogenase flavoprotein N-terminal domain-like0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
UBA domain0Direct
DNA gyrase/MutL, N-terminal domain0Direct
PUA domain0Direct
acyl-CoA oxidase N-terminal domains0Direct
ARID domain0Direct
Zn-finger domain of Sec23/240Direct
Arfaptin, Rac-binding fragment0Direct
Pleckstrin-homology domain (PH domain)0Direct
Tandem AAA-ATPase domain0.0003423Direct
Protein kinases, catalytic subunit0.01189Inherited
G proteins0.03702Inherited
Homeodomain0.0386Inherited
WD40-repeat0.04926Inherited
MSP-like0.06859Inherited
SH2 domain0.07115Inherited
PDZ domain0.07164Inherited
L-arabinose binding protein-like0.07164Inherited
Acetyl-CoA synthetase-like0.08625Inherited
Canonical RBD0.09456Inherited
CCCH zinc finger0.1039Inherited
ABC transporter ATPase domain-like0.1071Inherited
Tetratricopeptide repeat (TPR)0.1416Inherited
Cold shock DNA-binding domain-like0.1509Inherited
HLH, helix-loop-helix DNA-binding domain0.1644Inherited
Adenylyl and guanylyl cyclase catalytic domain0.1644Inherited
Calcium ATPase, transduction domain A0.1989Inherited
SH3-domain0.2307Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.2383Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.2383Inherited
Extended PAW domain0.2383Inherited
Elongation factors0.2383Inherited
DBL homology domain (DH-domain)0.2383Inherited
Histone lysine methyltransferases0.2383Inherited
Pepsin-like0.2383Inherited
Acetylcholinesterase-like0.2581Inherited
HMG-box0.2605Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.285Inherited
Extended AAA-ATPase domain0.3065Inherited
Multidrug efflux transporter AcrB transmembrane domain0.3077Inherited
6-phosphogluconate dehydrogenase-like, N-terminal domain0.312Inherited
Bromodomain0.312Inherited
FYVE, a phosphatidylinositol-3-phosphate binding domain0.312Inherited
Ankyrin repeat0.3134Inherited
Cytochrome P4500.3286Inherited
FAD/NAD-linked reductases, N-terminal and central domains0.3407Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP0.3735Inherited
Meta-cation ATPase, catalytic domain P0.3735Inherited
Crotonase-like0.3735Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.4051Inherited
TBP-associated factors, TAFs0.4059Inherited
Pumilio repeat0.4433Inherited
GABA-aminotransferase-like0.4433Inherited
FKBP immunophilin/proline isomerase0.4572Inherited
ABC transporter transmembrane region0.4658Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.4765Inherited
Cation efflux protein transmembrane domain-like0.4815Inherited
Glutathione S-transferase (GST), N-terminal domain0.5095Inherited
Hect, E3 ligase catalytic domain0.5257Inherited
Pyridoxal-dependent decarboxylase0.5257Inherited
Nicotinic receptor ligand binding domain-like0.538Inherited
I set domains0.565Inherited
Gastric lipase0.5698Inherited
Calpain large subunit, middle domain (domain III)0.5698Inherited
Myb/SANT domain0.5698Inherited
Papain-like0.5846Inherited
WW domain0.597Inherited
Class I alpha-1;2-mannosidase, catalytic domain0.6209Inherited
UBC-related0.638Inherited
Synaptotagmin-like (S variant)0.6642Inherited
Osmotin, thaumatin-like protein0.6757Inherited
Ubiquitin carboxyl-terminal hydrolase, UCH0.6914Inherited
BTB/POZ domain0.7049Inherited
Frizzled cysteine-rich domain0.7346Inherited
EF-hand modules in multidomain proteins0.7346Inherited
Transforming growth factor (TGF)-beta0.7346Inherited
PHD domain0.7653Inherited
H-NOX domain0.799Inherited
Cdc48 N-terminal domain-like0.799Inherited
Bacterial lipase0.799Inherited
MIT domain0.799Inherited
Ubiquitin-related0.8019Inherited
Voltage-gated potassium channels0.8088Inherited
PAZ domain0.8661Inherited
LIM domain0.8776Inherited
Glutathione S-transferase (GST), C-terminal domain0.9097Inherited
Leucine zipper domain0.9177Inherited
DnaQ-like 3'-5' exonuclease0.926Inherited
Calmodulin-like0.9421Inherited
Nuclear receptor ligand-binding domain0.9443Inherited
Ribonuclease PH domain 2-like0.9756Inherited
NagD-like0.9756Inherited
Ribonuclease PH domain 1-like0.9756Inherited
Choline/Carnitine O-acyltransferase1Inherited
RING finger domain, C3HC41Inherited
F-box domain1Inherited
Rhodopsin-like1Inherited
Nuclear receptor1Inherited
C-type lectin domain1Inherited
N-acetyl transferase, NAT1Inherited
Cyclophilin (peptidylprolyl isomerase)1Inherited
Glutathione peroxidase-like1Inherited
B-box zinc-binding domain1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Lipovitellin-phosvitin complex, superhelical domain0Direct
Outer arm dynein light chain 10Direct
Ribosomal L27 protein-like0Direct
DNA repair protein MutS, domain III0Direct
Polo-box domain0Direct
Kringle-like0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
Mitochondrial carrier0Direct
MFPT repeat-like0Direct
ADP-ribosylation0Direct
GroEL equatorial domain-like0Direct
Cu,Zn superoxide dismutase-like0Direct
beta-lactamase/transpeptidase-like0Direct
ArfGap/RecO-like zinc finger0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Restriction endonuclease-like0Direct
eIF4e-like0Direct
Chaperone J-domain0Direct
Thiolase-like0Direct
Surp module (SWAP domain)0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
Pentein0Direct
Subtilisin-like0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
MIR domain0Direct
Ribosomal protein L10Direct
Glutathione synthetase ATP-binding domain-like0Direct
RBP11-like subunits of RNA polymerase0Direct
Type II DNA topoisomerase0Direct
PABC (PABP) domain0Direct
Invertebrate chitin-binding proteins0Direct
Cadherin-like0Direct
Chitinase insertion domain0Direct
dsRNA-binding domain-like0Direct
Profilin (actin-binding protein)0Direct
SWIB/MDM2 domain0Direct
Acid phosphatase/Vanadium-dependent haloperoxidase0Direct
LysM domain0Direct
PAP/OAS1 substrate-binding domain0Direct
Zn-finger domain of Sec23/240Direct
Lamin A/C globular tail domain0Direct
CBD9-like0Direct
HCP-like0Direct
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase0Direct
FAD-dependent thiol oxidase0Direct
Class II aaRS ABD-related0Direct
alpha/beta knot0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Terpenoid cyclases/Protein prenyltransferases0Direct
Skp1 dimerisation domain-like0Direct
Cdc48 domain 2-like0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
LEM domain0Direct
Activating enzymes of the ubiquitin-like proteins0Direct
Citrate synthase0Direct
Heme-dependent peroxidases0Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Sec1/munc18-like (SM) proteins0Direct
MOSC N-terminal domain-like0Direct
GroES-like0Direct
Aldolase0Direct
Small-conductance potassium channel0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
lambda repressor-like DNA-binding domains0Direct
GAT-like domain0Direct
3-carboxy-cis,cis-mucoante lactonizing enzyme0Direct
Ran binding protein zinc finger-like0Direct
Phosphoenolpyruvate/pyruvate domain0Direct
Rap/Ran-GAP0Direct
Transducin (heterotrimeric G protein), gamma chain0Direct
MgtE membrane domain-like0Direct
FtsH protease domain-like0Direct
PurM N-terminal domain-like0Direct
Chromo domain-like0Direct
Tubby C-terminal domain-like0Direct
Annexin0Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
TK C-terminal domain-like0Direct
R3H domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Translational machinery components0Direct
Tubulin nucleotide-binding domain-like0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
2Fe-2S ferredoxin-like0Direct
t-snare proteins0Direct
Helical domain of Sec23/240Direct
PLP-binding barrel0Direct
Creatinase/prolidase N-terminal domain0Direct
Nucleoporin domain0Direct
Aquaporin-like0Direct
Galactose mutarotase-like0Direct
PK beta-barrel domain-like0Direct
SAND domain-like0Direct
SCP-like0Direct
Class I glutamine amidotransferase-like0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
Phosphoglucomutase, first 3 domains0Direct
Cullin homology domain0Direct
Thyroglobulin type-1 domain0Direct
Oxysterol-binding protein-like0Direct
PIN domain-like0Direct
Acyl-CoA dehydrogenase C-terminal domain-like0Direct
Proton glutamate symport protein0Direct
Spectrin repeat0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
Arginase/deacetylase0Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
Tubulin C-terminal domain-like0Direct
YWTD domain0Direct
CRAL/TRIO N-terminal domain0Direct
14-3-3 protein0Direct
Galactose oxidase, central domain0Direct
Clc chloride channel0Direct
Fibrinogen C-terminal domain-like0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Periplasmic binding protein-like II0Direct
Intermediate filament protein, coiled coil region0Direct
Domain of poly(ADP-ribose) polymerase0Direct
Integrin domains0Direct
GroEL-intermediate domain like0Direct
CAD & PB1 domains0Direct
ENTH/VHS domain0Direct
SIS domain0Direct
Composite domain of metallo-dependent hydrolases0Direct
S-adenosylmethionine synthetase0Direct
Purine and uridine phosphorylases0Direct
PYP-like sensor domain (PAS domain)0Direct
Second domain of FERM0Direct
Ribokinase-like0Direct
Smc hinge domain0Direct
Ribosomal proteins S24e, L23 and L15e0Direct
Sec63 N-terminal domain-like0Direct
Cystatin/monellin0Direct
L30e-like0Direct
Actin-like ATPase domain0Direct
PUA domain-like0Direct
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)0Direct
Protease propeptides/inhibitors0Direct
Phoshotransferase/anion transport protein0Direct
Carbohydrate phosphatase0Direct
GYF domain0Direct
PEP carboxykinase-like0Direct
Ribosomal protein S100Direct
Zn-binding ribosomal proteins0Direct
Tim10-like0Direct
YbiA-like0Direct
Clathrin adaptor appendage domain0Direct
Ribosomal protein L10-like0Direct
Diaminopimelate epimerase-like0Direct
cAMP-binding domain-like0Direct
Phosphoglucomutase, C-terminal domain0Direct
Carbonic anhydrase0Direct
Ribulose-phoshate binding barrel0Direct
SAICAR synthase-like0Direct
FF domain0Direct
Putative DNA-binding domain0Direct
HSP40/DnaJ peptide-binding domain0Direct
F1F0 ATP synthase subunit C0Direct
BEACH domain0Direct
alpha-catenin/vinculin-like0Direct
Formate/glycerate dehydrogenase catalytic domain-like0Direct
PEP carboxykinase N-terminal domain0Direct
Hormone receptor domain0Direct
Blood coagulation inhibitor (disintegrin)0Direct
WWE domain0Direct
Single hybrid motif0Direct
Acyl-CoA dehydrogenase NM domain-like0Direct
Families 57/38 glycoside transferase middle domain0Direct
Glycolipid transfer protein, GLTP0Direct
Elafin-like0Direct
Nop domain0Direct
VPS9 domain0Direct
Cytochrome c0Direct
Transducin (alpha subunit), insertion domain0Direct
GroEL apical domain-like0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
JAB1/MPN domain0Direct
ThrRS/AlaRS common domain0Direct
CO dehydrogenase ISP C-domain like0Direct
Carbon-nitrogen hydrolase0Direct
Rudiment single hybrid motif0Direct
Tricorn protease domain 20Direct
SPOC domain-like0Direct
DEATH domain0Direct
ARID-like0Direct
Succinyl-CoA synthetase domains0Direct
Terpenoid synthases0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Complement control module/SCR domain0Direct
Molybdenum cofactor-binding domain0Direct
SMAD MH1 domain0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
TGS-like0Direct
Radical SAM enzymes0Direct
Sec7 domain0Direct
LDH C-terminal domain-like0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
PurM C-terminal domain-like0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Nucleoside diphosphate kinase, NDK0Direct
PAP/Archaeal CCA-adding enzyme, C-terminal domain0Direct
AN1-like Zinc finger0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
HSP20-like chaperones0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Pepsin inhibitor-30Direct
PLC-like phosphodiesterases0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Troponin coil-coiled subunits0Direct
Integrin alpha N-terminal domain0Direct
PGBD-like0Direct
Cullin repeat-like0Direct
HSP90 C-terminal domain0Direct
Band 7/SPFH domain0Direct
PEBP-like0Direct
Doublecortin (DC)0Direct
PHM/PNGase F0Direct
ALDH-like0Direct
Insulin-like0Direct
Hypothetical protein c14orf129, hspc2100Direct
Cation efflux protein cytoplasmic domain-like0Direct
Hedgehog/intein (Hint) domain0Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0Direct
Heme-dependent catalase-like0Direct
Nucleotidyltransferase0Direct
ISP domain0Direct
Carboxypeptidase regulatory domain-like0Direct
Ferritin-like0Direct
L-aspartase-like0Direct
GAS2 domain-like0Direct
PreATP-grasp domain0Direct
WGR domain-like0Direct
Bacterial exopeptidase dimerisation domain0Direct
P-loop containing nucleoside triphosphate hydrolases0.000000128Direct
PH domain-like0.0000436Direct
Histone-fold0.0001106Direct
Protein kinase-like (PK-like)0.003581Inherited
TPR-like0.01729Inherited
Periplasmic binding protein-like I0.01738Inherited
PapD-like0.02572Inherited
ARM repeat0.03465Inherited
SH2 domain0.04055Inherited
"Winged helix" DNA-binding domain0.0424Inherited
PDZ domain-like0.04776Inherited
Homeodomain-like0.05029Inherited
WD40 repeat-like0.05999Inherited
Nucleic acid-binding proteins0.06074Inherited
Acetyl-CoA synthetase-like0.06265Inherited
Calponin-homology domain, CH-domain0.06265Inherited
Cyclin-like0.06946Inherited
CCCH zinc finger0.07711Inherited
EGF/Laminin0.078Inherited
Translation proteins0.09511Inherited
Galactose-binding domain-like0.09864Inherited
Nucleotide cyclase0.1169Inherited
HLH, helix-loop-helix DNA-binding domain0.1169Inherited
SMAD/FHA domain0.1172Inherited
Acid proteases0.1172Inherited
Calcium ATPase, transmembrane domain M0.13Inherited
Regulator of G-protein signaling, RGS0.144Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.144Inherited
SH3-domain0.1538Inherited
E set domains0.1562Inherited
Calcium ATPase, transduction domain A0.16Inherited
Quinoprotein alcohol dehydrogenase-like0.1771Inherited
Ankyrin repeat0.1884Inherited
Multidrug efflux transporter AcrB transmembrane domain0.1915Inherited
DBL homology domain (DH-domain)0.1962Inherited
ClpP/crotonase0.2174Inherited
HMG-box0.2174Inherited
(Trans)glycosidases0.2187Inherited
Cytochrome P4500.2187Inherited
PLP-dependent transferases0.244Inherited
POZ domain0.2575Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.2661Inherited
Bromodomain0.2661Inherited
RNA-binding domain, RBD0.2674Inherited
Cysteine proteinases0.2721Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.2739Inherited
RNI-like0.283Inherited
SNARE-like0.2938Inherited
ABC transporter transmembrane region0.2963Inherited
Lipocalins0.3053Inherited
Translation proteins SH3-like domain0.3588Inherited
Cation efflux protein transmembrane domain-like0.3588Inherited
Nicotinic receptor ligand binding domain-like0.371Inherited
Ubiquitin-like0.3875Inherited
Cysteine-rich domain0.4011Inherited
FKBP-like0.407Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.4079Inherited
Class II aaRS and biotin synthetases0.4666Inherited
Hect, E3 ligase catalytic domain0.4795Inherited
PRTase-like0.4795Inherited
DHS-like NAD/FAD-binding domain0.4795Inherited
Myosin rod fragments0.4795Inherited
BRCT domain0.5005Inherited
FYVE/PHD zinc finger0.5198Inherited
Ribosomal protein S5 domain 2-like0.5232Inherited
Calpain large subunit, middle domain (domain III)0.5285Inherited
Riboflavin synthase domain-like0.5285Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.5285Inherited
Cystine-knot cytokines0.5322Inherited
WW domain0.5322Inherited
Sm-like ribonucleoproteins0.5322Inherited
FAD-linked reductases, C-terminal domain0.5322Inherited
Voltage-gated potassium channels0.5365Inherited
Nucleotidylyl transferase0.5566Inherited
FAD/NAD(P)-binding domain0.56Inherited
SET domain0.5687Inherited
Seven-hairpin glycosidases0.5788Inherited
SAM/Pointed domain0.5816Inherited
UBC-like0.5932Inherited
Multidrug resistance efflux transporter EmrE0.5999Inherited
HAD-like0.6071Inherited
Osmotin, thaumatin-like protein0.6361Inherited
KA1-like0.6361Inherited
Nucleotide-binding domain0.6361Inherited
MFS general substrate transporter0.6675Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.6678Inherited
GST C-terminal domain-like0.6917Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.6968Inherited
S15/NS1 RNA-binding domain0.6994Inherited
4Fe-4S ferredoxins0.6994Inherited
Frizzled cysteine-rich domain0.6994Inherited
Ribonuclease H-like0.7316Inherited
PAZ domain0.7457Inherited
ADC-like0.7682Inherited
MIT domain0.7682Inherited
alpha/beta-Hydrolases0.8029Inherited
Fibronectin type III0.8093Inherited
Clavaminate synthase-like0.8449Inherited
EF-hand0.8492Inherited
Leucine zipper domain0.8583Inherited
GTPase activation domain, GAP0.8671Inherited
UBA-like0.8699Inherited
DNA/RNA polymerases0.9345Inherited
p53-like transcription factors0.9399Inherited
Ribonuclease PH domain 2-like0.9508Inherited
Thioredoxin-like0.9617Inherited
Immunoglobulin0.9618Inherited
Nuclear receptor ligand-binding domain0.973Inherited
Eukaryotic type KH-domain (KH-domain type I)0.9968Inherited
B-box zinc-binding domain1Inherited
F-box domain1Inherited
beta-beta-alpha zinc fingers1Inherited
CoA-dependent acyltransferases1Inherited
Ligand-binding domain in the NO signalling and Golgi transport1Inherited
Family A G protein-coupled receptor-like1Inherited
Cyclophilin-like1Inherited
Bet v1-like1Inherited
RING/U-box1Inherited
Saposin1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0Direct
    141673,50800
  • 141673 - MOSC N-terminal domain-like
  • 50800 - PK beta-barrel domain-like
  • 0Direct
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0Direct
    57889,48350
  • 57889 - Cysteine-rich domain
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    54897,53187
  • 54897 - Protease propeptides/inhibitors
  • 53187 - Zn-dependent exopeptidases
  • 0Direct
    141739,141739
  • 141739 - MFPT repeat-like
  • 141739 - MFPT repeat-like
  • 0Direct
    53187,55031
  • 53187 - Zn-dependent exopeptidases
  • 55031 - Bacterial exopeptidase dimerisation domain
  • 0Direct
    57414,57414
  • 57414 - Hairpin loop containing domain-like
  • 57414 - Hairpin loop containing domain-like
  • 0Direct
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    81383,52047
  • 81383 - F-box domain
  • 52047 - RNI-like
  • 0Direct
    57889,50729
  • 57889 - Cysteine-rich domain
  • 50729 - PH domain-like
  • 0Direct
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0Direct
    47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0Direct
    47741,56176
  • 47741 - CO dehydrogenase ISP C-domain like
  • 56176 - FAD-binding/transporter-associated domain-like
  • 0Direct
    81631,55003
  • 81631 - PAP/OAS1 substrate-binding domain
  • 55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain
  • 0Direct
    53738,53738
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 0Direct
    57756,50630
  • 57756 - Retrovirus zinc finger-like domains
  • 50630 - Acid proteases
  • 0Direct
    53474,53474
  • 53474 - alpha/beta-Hydrolases
  • 53474 - alpha/beta-Hydrolases
  • 0Direct
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0Direct
    48403,52151
  • 48403 - Ankyrin repeat
  • 52151 - FabD/lysophospholipase-like
  • 0Direct
    101690,53098
  • 101690 - PAZ domain
  • 53098 - Ribonuclease H-like
  • 0Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    53901,53901
  • 53901 - Thiolase-like
  • 53901 - Thiolase-like
  • 0Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0Direct
    51971,54373
  • 51971 - Nucleotide-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 0Direct
    161111,160240
  • 161111 - Cation efflux protein transmembrane domain-like
  • 160240 - Cation efflux protein cytoplasmic domain-like
  • 0Direct
    51735,56327
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 56327 - LDH C-terminal domain-like
  • 0Direct
    51735,55347
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 0Direct
    56601,48403
  • 56601 - beta-lactamase/transpeptidase-like
  • 48403 - Ankyrin repeat
  • 0Direct
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0Direct
    56059,52210
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52210 - Succinyl-CoA synthetase domains
  • 0Direct
    54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0Direct
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0Direct
    47576,47576
  • 47576 - Calponin-homology domain, CH-domain
  • 47576 - Calponin-homology domain, CH-domain
  • 0Direct
    57756,57756
  • 57756 - Retrovirus zinc finger-like domains
  • 57756 - Retrovirus zinc finger-like domains
  • 0Direct
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50129,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    82615,82615
  • 82615 - Polo-box domain
  • 82615 - Polo-box domain
  • 0Direct
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0Direct
    81301,81631
  • 81301 - Nucleotidyltransferase
  • 81631 - PAP/OAS1 substrate-binding domain
  • 0Direct
    52518,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    57863,48403
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0Direct
    52540,46785
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0Direct
    57903,82199
  • 57903 - FYVE/PHD zinc finger
  • 82199 - SET domain
  • 0Direct
    55326,56042
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 0Direct
    51735,50129
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 0Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0Direct
    64356,49447
  • 64356 - SNARE-like
  • 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor
  • 0Direct
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    54665,56003
  • 54665 - CO dehydrogenase molybdoprotein N-domain-like
  • 56003 - Molybdenum cofactor-binding domain
  • 0Direct
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0Direct
    52518,52922
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    56112,48371
  • 56112 - Protein kinase-like (PK-like)
  • 48371 - ARM repeat
  • 0Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    53187,49464
  • 53187 - Zn-dependent exopeptidases
  • 49464 - Carboxypeptidase regulatory domain-like
  • 0Direct
    81698,81698
  • 81698 - FF domain
  • 81698 - FF domain
  • 0Direct
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57362,57362
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 0Direct
    57938,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    161093,161093
  • 161093 - MgtE membrane domain-like
  • 161093 - MgtE membrane domain-like
  • 0Direct
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0Direct
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0Direct
    54292,47741
  • 54292 - 2Fe-2S ferredoxin-like
  • 47741 - CO dehydrogenase ISP C-domain like
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    52283,51735
  • 52283 - Formate/glycerate dehydrogenase catalytic domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    88713,88688
  • 88713 - Glycoside hydrolase/deacetylase
  • 88688 - Families 57/38 glycoside transferase middle domain
  • 0Direct
    55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    81383,50978
  • 81383 - F-box domain
  • 50978 - WD40 repeat-like
  • 0Direct
    51905,56425
  • 51905 - FAD/NAD(P)-binding domain
  • 56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
  • 0Direct
    56672,100879
  • 56672 - DNA/RNA polymerases
  • 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain
  • 0Direct
    68923,53795
  • 68923 - PEP carboxykinase N-terminal domain
  • 53795 - PEP carboxykinase-like
  • 0Direct
    57850,117839
  • 57850 - RING/U-box
  • 117839 - WWE domain
  • 0Direct
    49348,55711
  • 49348 - Clathrin adaptor appendage domain
  • 55711 - Subdomain of clathrin and coatomer appendage domain
  • 0Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0Direct
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    54236,54236
  • 54236 - Ubiquitin-like
  • 54236 - Ubiquitin-like
  • 0Direct
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    144232,82199
  • 144232 - HIT/MYND zinc finger-like
  • 82199 - SET domain
  • 0Direct
    50044,52540
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    49742,49742
  • 49742 - PHM/PNGase F
  • 49742 - PHM/PNGase F
  • 0Direct
    52540,81271
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 81271 - TGS-like
  • 0Direct
    50156,50044
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    46938,52087
  • 46938 - CRAL/TRIO N-terminal domain
  • 52087 - CRAL/TRIO domain
  • 0Direct
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0Direct
    55394,55394
  • 55394 - Bactericidal permeability-increasing protein, BPI
  • 55394 - Bactericidal permeability-increasing protein, BPI
  • 0Direct
    54211,55060
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55060 - GHMP Kinase, C-terminal domain
  • 0Direct
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0Direct
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0Direct
    51445,51445
  • 51445 - (Trans)glycosidases
  • 51445 - (Trans)glycosidases
  • 0Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0Direct
    47769,47769
  • 47769 - SAM/Pointed domain
  • 47769 - SAM/Pointed domain
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    81324,81327
  • 81324 - Voltage-gated potassium channels
  • 81327 - Small-conductance potassium channel
  • 0Direct
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    52047,48371
  • 52047 - RNI-like
  • 48371 - ARM repeat
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    46785,46785
  • 46785 - "Winged helix" DNA-binding domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    54897,52743
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 0Direct
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0Direct
    47473,103506
  • 47473 - EF-hand
  • 103506 - Mitochondrial carrier
  • 0Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    52540,140990
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 140990 - FtsH protease domain-like
  • 0Direct
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    55920,46785
  • 55920 - Creatinase/aminopeptidase
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    53738,55957
  • 53738 - Phosphoglucomutase, first 3 domains
  • 55957 - Phosphoglucomutase, C-terminal domain
  • 0Direct
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0Direct
    74650,51445
  • 74650 - Galactose mutarotase-like
  • 51445 - (Trans)glycosidases
  • 0Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    51556,51338
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0Direct
    47587,56399
  • 47587 - Domain of poly(ADP-ribose) polymerase
  • 56399 - ADP-ribosylation
  • 0Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0Direct
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    48464,89009
  • 48464 - ENTH/VHS domain
  • 89009 - GAT-like domain
  • 0Direct
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0Direct
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0Direct
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    51445,54556
  • 51445 - (Trans)glycosidases
  • 54556 - Chitinase insertion domain
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    50978,50998
  • 50978 - WD40 repeat-like
  • 50998 - Quinoprotein alcohol dehydrogenase-like
  • 0Direct
    51338,51556
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 0Direct
    48425,50729
  • 48425 - Sec7 domain
  • 50729 - PH domain-like
  • 0Direct
    56112,82615
  • 56112 - Protein kinase-like (PK-like)
  • 82615 - Polo-box domain
  • 0Direct
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    52743,49785
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0Direct
    52047,52047
  • 52047 - RNI-like
  • 52047 - RNI-like
  • 0Direct
    57625,57625
  • 57625 - Invertebrate chitin-binding proteins
  • 57625 - Invertebrate chitin-binding proteins
  • 0Direct
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0Direct
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    55729,55729
  • 55729 - Acyl-CoA N-acyltransferases (Nat)
  • 55729 - Acyl-CoA N-acyltransferases (Nat)
  • 0Direct
    103473,103473
  • 103473 - MFS general substrate transporter
  • 103473 - MFS general substrate transporter
  • 0Direct
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0Direct
    57196,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    47203,47203
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0Direct
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0Direct
    82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    48179,48179
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00252Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.01561Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.1172Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.144Inherited
    56112,55073
  • 56112 - Protein kinase-like (PK-like)
  • 55073 - Nucleotide cyclase
  • 0.144Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.1748Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.2174Inherited
    56436,49854
  • 56436 - C-type lectin-like
  • 49854 - Spermadhesin, CUB domain
  • 0.2625Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.2661Inherited
    51735,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0.2661Inherited
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0.2938Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2963Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.3246Inherited
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.3246Inherited
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.3588Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.3801Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.4079Inherited
    48403,48403
  • 48403 - Ankyrin repeat
  • 48403 - Ankyrin repeat
  • 0.4795Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.4976Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 0.5208Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.5285Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.5599Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.5788Inherited
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0.6361Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.6361Inherited
    51905,54373
  • 51905 - FAD/NAD(P)-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 0.6753Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.6753Inherited
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0.6994Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.6994Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.7682Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.8519Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.8992Inherited
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0.9508Inherited
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.959Inherited
    53300,56436
  • 53300 - vWA-like
  • 56436 - C-type lectin-like
  • 1Inherited
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 1Inherited
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 1Inherited
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57362,57362,57362
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 0Direct
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    48726,49265,48726
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    50156,50044,52540
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    81301,81631,55003
  • 81301 - Nucleotidyltransferase
  • 81631 - PAP/OAS1 substrate-binding domain
  • 55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain
  • 0Direct
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    51735,48179,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0Direct
    63411,63411,63411
  • 63411 - LuxS/MPP-like metallohydrolase
  • 63411 - LuxS/MPP-like metallohydrolase
  • 63411 - LuxS/MPP-like metallohydrolase
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    56112,82615,82615
  • 56112 - Protein kinase-like (PK-like)
  • 82615 - Polo-box domain
  • 82615 - Polo-box domain
  • 0Direct
    82895,82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    74650,51445,51011
  • 74650 - Galactose mutarotase-like
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0Direct
    53738,53738,55957
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 55957 - Phosphoglucomutase, C-terminal domain
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0Direct
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    48452,48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0Direct
    50249,50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    50129,51735,50129
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 0Direct
    53738,53738,53738
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 0Direct
    49785,49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0Direct
    48371,48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    57414,57414,57414
  • 57414 - Hairpin loop containing domain-like
  • 57414 - Hairpin loop containing domain-like
  • 57414 - Hairpin loop containing domain-like
  • 0Direct
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    81296,81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 81296 - E set domains
  • 0Direct
    57625,57625,57625
  • 57625 - Invertebrate chitin-binding proteins
  • 57625 - Invertebrate chitin-binding proteins
  • 57625 - Invertebrate chitin-binding proteins
  • 0Direct
    54928,54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    55973,55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0Direct
    46938,52087,101576
  • 46938 - CRAL/TRIO N-terminal domain
  • 52087 - CRAL/TRIO domain
  • 101576 - Supernatant protein factor (SPF), C-terminal domain
  • 0Direct
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    57567,57567,57567
  • 57567 - Serine protease inhibitors
  • 57567 - Serine protease inhibitors
  • 57567 - Serine protease inhibitors
  • 0Direct
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    56436,49854,49854
  • 56436 - C-type lectin-like
  • 49854 - Spermadhesin, CUB domain
  • 49854 - Spermadhesin, CUB domain
  • 0Direct
    57938,49493,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0Direct
    54292,47741,56176
  • 54292 - 2Fe-2S ferredoxin-like
  • 47741 - CO dehydrogenase ISP C-domain like
  • 56176 - FAD-binding/transporter-associated domain-like
  • 0Direct
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    54897,52743,49785
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0Direct
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    50044,50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0Direct
    56645,47203,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0Direct
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.16Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.3951Inherited
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.3951Inherited
    56436,56436,49854
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 49854 - Spermadhesin, CUB domain
  • 0.4066Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.4795Inherited
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.8763Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9852Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 1Inherited


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