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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

• Disease Ontology (DO) Ontology (DO)
  DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
  
• Human Phenotype (HP) Ontology (HP)
  HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
  
• Mouse Phenotype (MP) Ontology (MP)
  MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
  
• Worm Phenotype (WP) Ontology (WP)
  WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
  
• Yeast Phenotype (YP) Ontology (YP)
  Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
  
• Fly Phenotype (FP) Ontology (FP)
  FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
  
• Fly Anatomy (FA) Ontology (FA)
  FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
  
• Zebrafish Anatomy (ZA) Ontology (ZA)
  ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
  
• Xenopus Anatomy (XA) Ontology (XA)
  XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
  
• Arabidopsis Plant Ontology (AP) Ontology (AP)
  As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
  
• Enzyme Commission (EC) Ontology (EC)
  Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
  
• DrugBank ATC (DB) Ontology (DB)
  In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
  
• UniProtKB KeyWords (KW) Ontology (KW)
  Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
  
• UniProtKB UniPathway (UP) Ontology (UP)
  UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
  

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
  

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
  

Superfamily domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
SCP-like	0	DIRECT
CAD & PB1 domains	0	DIRECT
FtsH protease domain-like	0	DIRECT
Tubby C-terminal domain-like	0	DIRECT
TK C-terminal domain-like	0	DIRECT
Ribosomal protein L1	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
Ribosomal proteins S24e, L23 and L15e	0	DIRECT
Heme-dependent catalase-like	0	DIRECT
Ferritin-like	0	DIRECT
Cullin repeat-like	0	DIRECT
LysM domain	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Lipovitellin-phosvitin complex; beta-sheet shell regions	0	DIRECT
Cystatin/monellin	0	DIRECT
Tryptophan synthase beta subunit-like PLP-dependent enzymes	0	DIRECT
CBD9-like	0	DIRECT
Galactose mutarotase-like	0	DIRECT
alpha-catenin/vinculin-like	0	DIRECT
AN1-like Zinc finger	0	DIRECT
MIR domain	0	DIRECT
Ribosomal protein S18	0	DIRECT
Formate/glycerate dehydrogenase catalytic domain-like	0	DIRECT
PUA domain-like	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Thiolase-like	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
HRDC-like	0	DIRECT
Carbohydrate phosphatase	0	DIRECT
PLC-like phosphodiesterases	0	DIRECT
Integrin domains	0	DIRECT
Aquaporin-like	0	DIRECT
ADP-ribosylation	0	DIRECT
GroEL equatorial domain-like	0	DIRECT
SAND domain-like	0	DIRECT
t-snare proteins	0	DIRECT
ArfGap/RecO-like zinc finger	0	DIRECT
R3H domain	0	DIRECT
Nucleotidyltransferase	0	DIRECT
ACP-like	0	DIRECT
Carbon-nitrogen hydrolase	0	DIRECT
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
Chromo domain-like	0	DIRECT
PGBD-like	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
ALDH-like	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Ribosomal L27 protein-like	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
beta-lactamase/transpeptidase-like	0	DIRECT
Mitochondrial carrier	0	DIRECT
ISP domain	0	DIRECT
Aldolase	0	DIRECT
SIS domain	0	DIRECT
3-carboxy-cis,cis-mucoante lactonizing enzyme	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
Thiamin diphosphate-binding fold (THDP-binding)	0	DIRECT
Galactose oxidase, central domain	0	DIRECT
Class I glutamine amidotransferase-like	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
MgtE membrane domain-like	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
ENTH/VHS domain	0	DIRECT
Families 57/38 glycoside transferase middle domain	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0	DIRECT
Activating enzymes of the ubiquitin-like proteins	0	DIRECT
Acyl-CoA dehydrogenase C-terminal domain-like	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
WGR domain-like	0	DIRECT
cAMP-binding domain-like	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
Kringle-like	0	DIRECT
Acetyl-CoA synthetase-like	0	DIRECT
Doublecortin (DC)	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0	DIRECT
eIF4e-like	0	DIRECT
Citrate synthase	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
Terpenoid synthases	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
Oxysterol-binding protein-like	0	DIRECT
Aminoacid dehydrogenase-like, N-terminal domain	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
LEM domain	0	DIRECT
PHM/PNGase F	0	DIRECT
Actin-like ATPase domain	0	DIRECT
PreATP-grasp domain	0	DIRECT
dsRNA-binding domain-like	0	DIRECT
PLP-binding barrel	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
PK beta-barrel domain-like	0	DIRECT
Phoshotransferase/anion transport protein	0	DIRECT
VPS9 domain	0	DIRECT
Creatinase/prolidase N-terminal domain	0	DIRECT
Arginase/deacetylase	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
Complement control module/SCR domain	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
Spectrin repeat	0	DIRECT
Insulin-like	0	DIRECT
L30e-like	0	DIRECT
SPOC domain-like	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
Tim10-like	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
FAD-linked oxidases, C-terminal domain	0	DIRECT
Rap/Ran-GAP	0	DIRECT
PIN domain-like	0	DIRECT
BEACH domain	0	DIRECT
DEATH domain	0	DIRECT
YWTD domain	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
YbiA-like	0	DIRECT
Single hybrid motif	0	DIRECT
Lipovitellin-phosvitin complex, superhelical domain	0	DIRECT
Nucleoporin domain	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
MFPT repeat-like	0	DIRECT
GAS2 domain-like	0	DIRECT
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0	DIRECT
Terpenoid cyclases/Protein prenyltransferases	0	DIRECT
SMAD MH1 domain	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
Tricorn protease domain 2	0	DIRECT
Hormone receptor domain	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
Carbonic anhydrase	0	DIRECT
Band 7/SPFH domain	0	DIRECT
ARID-like	0	DIRECT
Isocitrate/Isopropylmalate dehydrogenase-like	0	DIRECT
GAT-like domain	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
alpha/beta knot	0	DIRECT
Sec63 N-terminal domain-like	0	DIRECT
Sec7 domain	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
Phosphoenolpyruvate/pyruvate domain	0	DIRECT
14-3-3 protein	0	DIRECT
Nop domain	0	DIRECT
Tubulin nucleotide-binding domain-like	0	DIRECT
LDH C-terminal domain-like	0	DIRECT
Carboxypeptidase regulatory domain-like	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Cytochrome c	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
PAP/OAS1 substrate-binding domain	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
Subtilisin-like	0	DIRECT
GroES-like	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
Small-conductance potassium channel	0	DIRECT
HSP20-like chaperones	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
Integrin alpha N-terminal domain	0	DIRECT
lambda repressor-like DNA-binding domains	0	DIRECT
2Fe-2S ferredoxin-like	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
PABC (PABP) domain	0	DIRECT
Heme-dependent peroxidases	0	DIRECT
SAICAR synthase-like	0	DIRECT
Restriction endonuclease-like	0	DIRECT
Chitinase insertion domain	0	DIRECT
Clathrin adaptor appendage domain	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Radical SAM enzymes	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Clc chloride channel	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Tubulin C-terminal domain-like	0	DIRECT
Smc hinge domain	0	DIRECT
PYP-like sensor domain (PAS domain)	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
Periplasmic binding protein-like II	0	DIRECT
Chaperone J-domain	0	DIRECT
Ribulose-phoshate binding barrel	0	DIRECT
Annexin	0	DIRECT
HCP-like	0	DIRECT
Class II aaRS ABD-related	0	DIRECT
PEBP-like	0	DIRECT
Putative DNA-binding domain	0	DIRECT
WWE domain	0	DIRECT
JAB1/MPN domain	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	0	DIRECT
Subdomain of clathrin and coatomer appendage domain	0	DIRECT
Pentein	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
FAD-binding/transporter-associated domain-like	0	DIRECT
Hedgehog/intein (Hint) domain	0	DIRECT
Lamin A/C globular tail domain	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
Ribosomal protein S10	0	DIRECT
Acyl-CoA dehydrogenase NM domain-like	0	DIRECT
Intermediate filament protein, coiled coil region	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
GroEL apical domain-like	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
Second domain of FERM	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
Glutathione synthetase ATP-binding domain-like	0	DIRECT
GYF domain	0	DIRECT
Composite domain of metallo-dependent hydrolases	0	DIRECT
Zn-binding ribosomal proteins	0	DIRECT
Histone-fold	0	DIRECT
Acid phosphatase/Vanadium-dependent haloperoxidase	0	DIRECT
PEP carboxykinase-like	0	DIRECT
TGS-like	0	DIRECT
Diaminopimelate epimerase-like	0	DIRECT
Troponin coil-coiled subunits	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
FF domain	0	DIRECT
Ribokinase-like	0	DIRECT
Polo-box domain	0	DIRECT
ThrRS/AlaRS common domain	0	DIRECT
Protease propeptides/inhibitors	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
Translational machinery components	0	DIRECT
Invertebrate chitin-binding proteins	0	DIRECT
Rudiment single hybrid motif	0	DIRECT
L-aspartase-like	0	DIRECT
DNA ligase/mRNA capping enzyme, catalytic domain	0	DIRECT
Outer arm dynein light chain 1	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Cullin homology domain	0	DIRECT
Elafin-like	0	DIRECT
Cadherin-like	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
NagB/RpiA/CoA transferase-like	0	DIRECT
P-loop containing nucleoside triphosphate hydrolases	0.00000007798	DIRECT
PH domain-like	0.00001907	DIRECT
PDZ domain-like	0.008703	INHERITED FROM: acetylcholinesterase inhibitor response variant || aldicarb response variant || protein expression variant
TPR-like	0.01221	INHERITED FROM: positive chemotaxis defective || light body touch resistant || ivermectin resistant || ivermectin response variant || antihelmintic response variant
Periplasmic binding protein-like I	0.01392	INHERITED FROM: alkaline pH chemotaxis variant || mechanosensation variant || magnesium chemotaxis defective || carbon dioxide avoidance variant || iodide chemotaxis defective || memory retention defective || thermosensory behavior variant || chemosensory response variant || thermotaxis variant || diacetyl chemotaxis variant || aqueous chemosensory response variant || organism temperature response variant || chemotaxis variant || lithium chemotaxis defective || chemosensory behavior variant || AWC odorant chemotaxis variant || AWC odorant chemotaxis defective || benzaldehyde chemotaxis variant || bromide chemotaxis variant || iodide chemotaxis variant || organism environmental stimulus response variant || aqueous positive chemotaxis variant || bromide chemotaxis defective || second messenger mediated signaling variant
ARM repeat	0.01805	INHERITED FROM: RNAi response variant || gene expression variant || sick || sexually dimorphic physiology variant || organism metabolism processing variant || protein expression variant
ABC transporter transmembrane region	0.01964	INHERITED FROM: metal response variant || RNAi response variant || colchicine hypersensitive || cadmium response variant || RNAi resistant || organism environmental stimulus response variant
PapD-like	0.02301	INHERITED FROM: developmental growth variant || slow growth || dauer metabolism variant || larval growth variant || dauer lifespan extended || fat content variant || dauer lifespan variant || larval arrest || lipid metabolism variant
Protein kinase-like (PK-like)	0.04522	INHERITED FROM: protein phosphorylation variant || alkaline pH chemotaxis variant || mechanosensation variant || metal response variant || chemical response variant || colchicine resistant || aldicarb response variant || drug induced gene expression variant || chemosensory response variant || pathogen induced gene expression variant || mid larval arrest || octanol chemotaxis defective || chemotaxis variant || conflicting sensory integration variant || kinase activity reduced || protein modification variant || egg laying response to food variant || metabolic pathway variant || chemosensory behavior variant || anoxia resistant || lipid synthesis increased || dauer development variant || positive chemotaxis variant || organism osmostic stress hypersensitive || protein subcellular localization variant || protein expression variant || organism environmental stimulus response variant || life span variant || second messenger mediated signaling variant || protein phosphorylation reduced
Nucleic acid-binding proteins	0.04629	INHERITED FROM: hydroxyurea hypersensitive || nonsense mRNA accumulation || hypoxia resistant || mRNA surveillance defective || hydroxyurea response variant || sick || hermaphrodite physiology variant || sexually dimorphic physiology variant
Homeodomain-like	0.05168	INHERITED FROM: carbon dioxide avoidance variant || ectopic expression transgene || imipramine resistant || level of transgene expression variant || egg laying imipramine resistant || inhibitor of serotonin uptake variant || adrenergic receptor antagonist response variant || growth rate variant || organism metabolism processing variant || protein degradation variant || carbon dioxide response variant
WD40 repeat-like	0.06117	INHERITED FROM: osmotic avoidance variant || late larval arrest || early larval arrest || aldicarb response variant || protein protein interaction variant || protein aggregation induced behavior variant || hermaphrodite physiology variant || sexually dimorphic physiology variant || organism metabolism processing variant || antimicrobial gene expression variant || protein aggregation variant
CCCH zinc finger	0.06793	INHERITED FROM: ectopic expression transgene || gene expression variant || transgene expression variant || mRNA expression ectopic
FYVE/PHD zinc finger	0.07678	INHERITED FROM: ectopic expression transgene || organism UV response variant || gene expression variant || protein methylation variant || protein modification variant || organism UV hypersensitive || organism metabolism processing variant
Translation proteins	0.08478	INHERITED FROM: protein phosphorylation variant || protein phosphorylation increased || gene expression variant || protein protein interaction variant || receptor mediated endocytosis defective || transgene expression variant || proteasome core activity variant || mRNA levels increased || hermaphrodite physiology variant || sexually dimorphic physiology variant || organism metabolism processing variant || protein aggregation variant || oocyte physiology variant
"Winged helix" DNA-binding domain	0.0937	INHERITED FROM: anesthetic response variant || paraquat hypersensitive || protein expression increased || germline transgene silencing variant || protein protein interaction variant || spontaneous mutation rate increased || protein aggregation induced behavior variant || shortened life span || chemical hypersensitive || organism metabolism processing variant || life span variant || protein aggregation variant
Ankyrin repeat	0.09895	INHERITED FROM: organism heat response variant || odorant negative chemotaxis defective || octanol chemotaxis defective || octanol chemotaxis variant || chemotaxis variant
HLH, helix-loop-helix DNA-binding domain	0.09914	INHERITED FROM: aqueous positive chemotaxis defective || ectopic expression transgene || RNA expression variant || pathogen resistance increased || hypoxia response variant || fungal resistance increased || organism metabolism processing variant || lysine chemotaxis defective || gene expression level reduced
Nucleotide cyclase	0.09914	INHERITED FROM: cation positive chemotaxis defective || alkaline pH chemotaxis variant || magnesium chemotaxis defective || anion positive chemotaxis defective || iodide chemotaxis defective || osmotic avoidance variant || anion positive chemotaxis variant || chemosensory response variant || diacetyl chemotaxis variant || cation positive chemotaxis variant || aqueous chemosensory response variant || chemotaxis variant || lithium chemotaxis defective || chemosensory behavior variant || AWC odorant chemotaxis variant || AWC odorant chemotaxis defective || positive chemotaxis variant || bromide chemotaxis variant || iodide chemotaxis variant || organism environmental stimulus response variant || bromide chemotaxis defective || second messenger mediated signaling variant || carbon dioxide response variant
SMAD/FHA domain	0.1059	INHERITED FROM: aldicarb response variant || fat content reduced
BRCT domain	0.1059	INHERITED FROM: organism ionizing radiation response variant
Calcium ATPase, transmembrane domain M	0.1182	INHERITED FROM: lipid composition variant || nicotine hypersensitive
SH3-domain	0.123	INHERITED FROM: protein phosphorylation variant || aldicarb response variant || protein expression reduced || protein expression variant || protein metabolism variant
Metal cation-transporting ATPase, ATP-binding domain N	0.132	INHERITED FROM: lipid composition variant || nicotine hypersensitive || organism environmental stimulus response variant
Regulator of G-protein signaling, RGS	0.132	INHERITED FROM: mechanosensation variant || chemotaxis variant || negative chemotaxis variant
EGF/Laminin	0.1351	INHERITED FROM: odorant negative chemotaxis defective || octanol chemotaxis defective || octanol chemotaxis variant
Calcium ATPase, transduction domain A	0.147	INHERITED FROM: nicotine hypersensitive || organism environmental stimulus response variant
Acid proteases	0.147	INHERITED FROM: transgene subcellular localization variant || protein interaction variant || osmotic integrity variant || hypoosmotic shock hypersensitive || gene expression variant || protein protein interaction variant || transgene expression variant || organism metabolism processing variant || protein aggregation variant
Cysteine-rich domain	0.1548	INHERITED FROM: odorant chemosensory response variant || thermosensory behavior variant || aldicarb response variant || drug induced gene expression variant || thermotaxis variant || organism temperature response variant || response to injury variant || positive chemotaxis variant || organism metabolism processing variant || protein subcellular localization variant || bacterially unswollen || antimicrobial gene expression variant || odorant positive chemotaxis variant
Quinoprotein alcohol dehydrogenase-like	0.1639	INHERITED FROM: drug response variant || mid larval arrest || hypoxia response variant || mRNA levels increased || protein degradation variant || L2 arrest
Multidrug efflux transporter AcrB transmembrane domain	0.1689	INHERITED FROM: odorant chemosensory response variant || odorant positive chemotaxis defective || egg integrity defective early emb || positive chemotaxis defective || embryo osmotic integrity defective early emb
Cytochrome P450	0.1818	INHERITED FROM: metal response variant || metabolite content decreased || cadmium response variant
ClpP/crotonase	0.1826	INHERITED FROM: level of transgene expression variant || fat content variant || lipid metabolism variant
DBL homology domain (DH-domain)	0.1826	INHERITED FROM: pathogen resistance increased || aldicarb response variant || organism pathogen response variant || bacterially unswollen || organism environmental stimulus response variant
HMG-box	0.1826	INHERITED FROM: maintenance of gene silencing variant || transgene expression variant
E set domains	0.186	INHERITED FROM: paraquat hypersensitive
(Trans)glycosidases	0.1925	INHERITED FROM: pathogen susceptibility increased
Cyclin-like	0.2365	INHERITED FROM: protein phosphorylation variant || level of transgene expression variant || protein phosphorylation reduced
Cysteine proteinases	0.2428	INHERITED FROM: paraquat hypersensitive || protein interaction variant || osmotic integrity variant || hypoosmotic shock hypersensitive || protein protein interaction variant || pattern of transgene expression variant || organism metabolism processing variant || protein aggregation variant
6-phosphogluconate dehydrogenase C-terminal domain-like	0.2511	INHERITED FROM: fat content variant || lipid metabolism variant
Bromodomain	0.2511	INHERITED FROM: acute functional tolerance to alcohol defective || anesthetic response variant || drug adaptation variant || ethanol resistant || organism UV response variant || gene expression variant || anesthetic resistant || sick || organism UV hypersensitive || organism metabolism processing variant
Tudor/PWWP/MBT	0.2511	INHERITED FROM: pattern of transgene expression variant
POZ domain	0.2601	INHERITED FROM: L1 arrest || early larval arrest || protein aggregation induced behavior variant || resistant to protein aggregation induced paralysis || chemical hypersensitive
RNA-binding domain, RBD	0.2709	INHERITED FROM: maintenance of gene silencing variant || no induction of antimicrobial peptide expression after infection || innate immune response variant || RNA expression variant || alternative splicing variant || RNA processing variant || sick || mRNA export variant || organism metabolism processing variant || RNA metabolism variant || antimicrobial gene expression variant || starvation induced apoptosis variant
Lipocalins	0.2779	INHERITED FROM: paraquat hypersensitive || fat content variant || fat content increased || lipid metabolism variant
SNARE-like	0.2789	INHERITED FROM: transgene subcellular localization variant || acetylcholinesterase inhibitor resistant || gene expression variant || transgene expression variant || aldicarb resistant || sick || pattern of transgene expression variant || organism metabolism processing variant
Metallo-dependent phosphatases	0.2804	INHERITED FROM: germ cell resistant ionizing radiation || radiation induced germ cell apoptosis resistant
Cation efflux protein transmembrane domain-like	0.343	INHERITED FROM: metal response variant || manganese toxicity resistant || manganese response variant || cadmium hypersensitive
Translation proteins SH3-like domain	0.343	INHERITED FROM: early larval arrest || gene expression variant || transgene expression variant || organism metabolism processing variant
PX domain	0.343	INHERITED FROM: protein expression reduced || protein subcellular localization variant || protein expression variant
HAD-like	0.3625	INHERITED FROM: nicotine hypersensitive
Nicotinic receptor ligand binding domain-like	0.375	INHERITED FROM: mechanosensation variant || chemical response variant || slowing response on food variant || sodium chloride chemotaxis variant || nicotine resistant || thermosensory behavior variant || cholinergic agonist resistant || drug response variant || chemosensory response variant || hypoosmotic shock hypersensitive || organism temperature response variant || chemotaxis variant || antihelmintic response variant || chemosensory behavior variant || AWC odorant chemotaxis variant || positive chemotaxis variant || selenium response variant || DMPP response variant || benzaldehyde chemotaxis variant || organism environmental stimulus response variant
Ubiquitin-like	0.3922	INHERITED FROM: heteroplasmy || protein interaction variant || protein protein interaction variant || organism metabolism processing variant || protein aggregation variant
Neurotransmitter-gated ion-channel transmembrane pore	0.4114	INHERITED FROM: mechanosensation variant || chemical response variant || slowing response on food variant || sodium chloride chemotaxis variant || nicotine resistant || thermosensory behavior variant || cholinergic agonist resistant || drug response variant || chemosensory response variant || hypoosmotic shock hypersensitive || organism temperature response variant || chemotaxis variant || antihelmintic response variant || chemosensory behavior variant || AWC odorant chemotaxis variant || positive chemotaxis variant || selenium response variant || DMPP response variant || benzaldehyde chemotaxis variant || organism environmental stimulus response variant
RNI-like	0.4179	INHERITED FROM: resistant to protein aggregation induced paralysis
FKBP-like	0.4192	INHERITED FROM: transgene subcellular localization variant || protein interaction variant || protein protein interaction variant || pattern of transgene expression variant || protein aggregation variant
HD-domain/PDEase-like	0.4192	INHERITED FROM: thermosensory behavior variant || thermotaxis variant || organism temperature response variant
Class II aaRS and biotin synthetases	0.4353	INHERITED FROM: oxygen response variant || gene expression variant || hypoxia response variant || hypoxia resistant || receptor mediated endocytosis defective || transgene expression variant || hermaphrodite physiology variant || sexually dimorphic physiology variant || organism metabolism processing variant || organism environmental stimulus response variant || oocyte physiology variant
DHS-like NAD/FAD-binding domain	0.4642	INHERITED FROM: protein acetylation variant || metabolic pathway variant
Myosin rod fragments	0.4642	INHERITED FROM: drug resistant || hermaphrodite physiology variant || sexually dimorphic physiology variant
PRTase-like	0.4642	INHERITED FROM: Fluorouracil resistant || drug resistant
Hect, E3 ligase catalytic domain	0.4642	INHERITED FROM: transgene subcellular localization variant || protein interaction variant || gene expression variant || protein protein interaction variant || protein aggregation induced behavior variant || transgene expression variant || cell stress response variant || pattern of transgene expression variant || organism metabolism processing variant || germ cell ionizing radiation response variant || protein aggregation variant
Ribosomal protein S5 domain 2-like	0.4963	INHERITED FROM: early larval arrest
Galactose-binding domain-like	0.4963	INHERITED FROM: protein interaction variant || protein protein interaction variant || protein aggregation variant
Cystine-knot cytokines	0.5003	INHERITED FROM: nicotine response variant || levamisole response variant
WW domain	0.5003	INHERITED FROM: maintenance of gene silencing variant
Sm-like ribonucleoproteins	0.5003	INHERITED FROM: unfolded protein response variant || organism heat response variant || gene expression variant || receptor mediated endocytosis defective || transgene expression variant || sick || hermaphrodite physiology variant || pattern of transgene expression variant || sexually dimorphic physiology variant || protein subcellular localization variant || life span variant
SH2 domain	0.5041	INHERITED FROM: level of protein expression variant || protein expression reduced || protein expression variant
Calpain large subunit, middle domain (domain III)	0.5108	INHERITED FROM: metabolic pathway variant || protein degradation variant || protein metabolism variant
Riboflavin synthase domain-like	0.5108	INHERITED FROM: pattern protein expression variant
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.5108	INHERITED FROM: pattern protein expression variant
FAD/NAD(P)-binding domain	0.5223	INHERITED FROM: ATP levels reduced || pesticide response variant || ATP levels variant || life span variant
FAD-linked reductases, C-terminal domain	0.5355	INHERITED FROM: life span variant
Voltage-gated potassium channels	0.5365	INHERITED FROM: mechanosensation variant || serotonin response variant || positive chemotaxis defective || serotonin resistant || adrenergic receptor antagonist response variant || growth rate variant || protein degradation variant
SAM/Pointed domain	0.5432	INHERITED FROM: aldicarb response variant || gene expression level reduced
Nucleotidylyl transferase	0.5432	INHERITED FROM: oxygen response variant || paraquat resistant || transgene expression increased || hypoxia response variant || hypoxia resistant || organism metabolism processing variant || organism environmental stimulus response variant
UBC-like	0.5454	INHERITED FROM: transgene subcellular localization variant || late larval arrest || protein interaction variant || protein protein interaction variant || sick || pattern of transgene expression variant || organism metabolism processing variant || protein aggregation variant
SET domain	0.5454	INHERITED FROM: maintenance of gene silencing variant || dosage compensation variant || RNAi response variant || ectopic expression antibody || histone methylation variant || gene expression variant || spontaneous mutation rate increased || protein methylation variant || protein modification variant || shortened life span || pattern of transgene expression variant || organism metabolism processing variant || protein metabolism variant || life span variant
Seven-hairpin glycosidases	0.5661	INHERITED FROM: extended life span || protein protein interaction variant || protein aggregation variant
Multidrug resistance efflux transporter EmrE	0.5717	INHERITED FROM: pathogen resistance increased || bacterially unswollen
PLP-dependent transferases	0.5893	INHERITED FROM: germ cell resistant ionizing radiation || radiation induced germ cell apoptosis resistant
C2 domain (Calcium/lipid-binding domain, CaLB)	0.6053	INHERITED FROM: drug resistant || chemical response variant || RNAi response variant || drug induced gene expression variant || response to injury variant || gonad sheath contractions variant || aging variant || growth rate variant || cell stress response variant || gonad sheath contraction rate reduced || protein subcellular localization variant || protein expression variant || organism environmental stimulus response variant || antimicrobial gene expression variant || somatic sheath physiology variant
Di-copper centre-containing domain	0.6214	INHERITED FROM: organism stress response variant || organism ionizing radiation response variant || cell stress response variant || cell ionizing radiation response variant || germ cell ionizing radiation response variant
Nucleotide-binding domain	0.6214	INHERITED FROM: extended life span
KA1-like	0.6214	INHERITED FROM: RNA expression variant
HIT/MYND zinc finger-like	0.6475	INHERITED FROM: pattern of transgene expression variant
S-adenosyl-L-methionine-dependent methyltransferases	0.6484	INHERITED FROM: cell gamma ray response variant || organism gamma ray response variant || gamma ray induced apoptosis increased
MFS general substrate transporter	0.6858	INHERITED FROM: organism high sodium chloride hypersensitive
4Fe-4S ferredoxins	0.686	INHERITED FROM: transgene expression increased || life span variant
S15/NS1 RNA-binding domain	0.686	INHERITED FROM: transgene expression increased
Frizzled cysteine-rich domain	0.686	INHERITED FROM: antibody staining variant || transgene expression reduced
GST C-terminal domain-like	0.6916	INHERITED FROM: organism stress response variant || metal response variant || organism electrophilic stress hypersensitive || organism heat hypersensitive || enzyme activity reduced || enzyme activity variant || organism environmental stimulus response variant || cadmium hypersensitive
alpha/beta-Hydrolases	0.7487	INHERITED FROM: acetylcholinesterase reduced || acetylcholinesterase activity variant
EF-hand	0.7546	INHERITED FROM: protein interaction variant || aldicarb response variant || gonad sheath contractions variant || osmotic stress response variant || protein aggregation variant || somatic sheath physiology variant
ADC-like	0.7553	INHERITED FROM: protein interaction variant || protein protein interaction variant || metabolic pathway variant || protein metabolism variant || transgene expression reduced || protein aggregation variant
MIT domain	0.7553	INHERITED FROM: protein interaction variant || protein protein interaction variant || protein aggregation variant
Clavaminate synthase-like	0.8079	INHERITED FROM: histone methylation variant || protein methylation variant || life span variant
NAD kinase/diacylglycerol kinase-like	0.813	INHERITED FROM: organism stress response variant || thermosensory behavior variant || thermotaxis variant
Cyclophilin-like	0.8208	INHERITED FROM: transgene subcellular localization variant || protein interaction variant || gene expression variant || protein protein interaction variant || transgene expression variant || pattern of transgene expression variant || protein aggregation variant
CoA-dependent acyltransferases	0.8208	INHERITED FROM: organism metabolism processing variant
UBA-like	0.8318	INHERITED FROM: protein protein interaction variant || protein aggregation variant
SNF-like	0.8516	INHERITED FROM: drug hypersensitive
Leucine zipper domain	0.857	INHERITED FROM: mRNA levels reduced || pathogen susceptibility increased || level of transgene expression variant || pore forming toxin response variant || mRNA expression variant || transgene expression reduced
GTPase activation domain, GAP	0.8655	INHERITED FROM: protein expression variant
Thioredoxin-like	0.895	INHERITED FROM: organism stress response variant || metal response variant || organism electrophilic stress hypersensitive || paraquat response variant || organism heat hypersensitive || enzyme activity reduced || enzyme activity variant || cadmium hypersensitive
Glucocorticoid receptor-like (DNA-binding domain)	0.9043	INHERITED FROM: SDS sensitive dauer || level of transgene expression variant || dauer resistance to harsh conditions variant || gene expression level high || fat content increased || gene expression level reduced || transgene expression reduced
p53-like transcription factors	0.9044	INHERITED FROM: ectopic expression transgene || level of transgene expression variant || gene expression level reduced
Immunoglobulin	0.9093	INHERITED FROM: aldicarb response variant || growth rate variant || protein degradation variant
Ribonuclease PH domain 2-like	0.9313	INHERITED FROM: early larval arrest
DNA/RNA polymerases	0.9349	INHERITED FROM: DNA repair variant || DNA metabolism variant
Saposin	0.9568	INHERITED FROM: germ cell resistant ionizing radiation || radiation induced germ cell apoptosis resistant || level of transgene expression variant || pathogen load variant || increased pathogen survival || germ cell ionizing radiation response variant || transgene expression reduced
Ribonuclease H-like	0.9727	INHERITED FROM: maintenance of gene silencing variant || RNAi response variant || somatic transgene silencing variant || RNA expression variant || RNAi enhanced || 21U RNA expression variant || siRNA expression variant
PAZ domain	0.99	INHERITED FROM: maintenance of gene silencing variant || RNAi response variant || somatic transgene silencing variant || RNA expression variant || RNAi enhanced || 21U RNA expression variant || mRNA levels increased || siRNA expression variant
RING/U-box	1	INHERITED FROM: transgene subcellular localization variant || protein interaction variant || gene expression variant || protein protein interaction variant || organism ionizing radiation response variant || pattern of transgene expression variant || organism metabolism processing variant || germ cell hypersensitive ionizing radiation || cell ionizing radiation response variant || germ cell ionizing radiation response variant || protein aggregation variant
Nuclear receptor ligand-binding domain	1	INHERITED FROM: SDS sensitive dauer || level of transgene expression variant || dauer resistance to harsh conditions variant || gene expression level high || fat content increased || gene expression level reduced || transgene expression reduced
Bet v1-like	1	INHERITED FROM: growth rate variant
B-box zinc-binding domain	1	INHERITED FROM: transgene subcellular localization variant || protein interaction variant || gene expression variant || protein protein interaction variant || transgene expression variant || organism metabolism processing variant || protein aggregation variant
F-box domain	1	INHERITED FROM: resistant to protein aggregation induced paralysis
Snake toxin-like	1	INHERITED FROM: fat content reduced
Ligand-binding domain in the NO signalling and Golgi transport	1	INHERITED FROM: carbon dioxide avoidance variant || carbon dioxide response variant
Family A G protein-coupled receptor-like	1	INHERITED FROM: male tail curling serotonin variant || serotonin induced fat reduction variant || locomotion rate serotonin variant || serotonin induced pumping variant
beta-beta-alpha zinc fingers	1	INHERITED FROM: imipramine resistant || egg laying imipramine resistant || inhibitor of serotonin uptake variant || organism metabolism processing variant

Family domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Ribosomal protein S10	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
RNA-polymerase beta-prime	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
Sec7 domain	0	DIRECT
Carbonic anhydrase	0	DIRECT
XPF/Rad1/Mus81 nuclease	0	DIRECT
Serum paraoxonase/arylesterase 1, PON1	0	DIRECT
Armadillo repeat	0	DIRECT
Clc chloride channel	0	DIRECT
Troponin I	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
MutT-like	0	DIRECT
Matrix metalloproteases, catalytic domain	0	DIRECT
COMT-like	0	DIRECT
Thiolase-related	0	DIRECT
Type II chitinase	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Sir2 family of transcriptional regulators	0	DIRECT
POU-specific domain	0	DIRECT
Glycosyl transferases group 1	0	DIRECT
alpha-mannosidase	0	DIRECT
YihX-like	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
NTF2-like	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
Protein prenyltransferases	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Paired domain	0	DIRECT
VHS domain	0	DIRECT
GYF domain	0	DIRECT
AMPK-beta glycogen binding domain-like	0	DIRECT
U-box	0	DIRECT
D-aminoacid oxidase-like	0	DIRECT
ALDH-like	0	DIRECT
Proprotein convertase P-domain	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Hydantoinase (dihydropyrimidinase), catalytic domain	0	DIRECT
beta-Lactamase/D-ala carboxypeptidase	0	DIRECT
Pumilio repeat	0	DIRECT
alpha-catenin/vinculin	0	DIRECT
Band 7/SPFH domain	0	DIRECT
Hexokinase	0	DIRECT
Oxysterol-binding protein	0	DIRECT
DPP6 catalytic domain-like	0	DIRECT
5' to 3' exonuclease catalytic domain	0	DIRECT
Cofilin-like	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
Acetyl-CoA synthetase-like	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
CO dehydrogenase flavoprotein N-terminal domain-like	0	DIRECT
Gamma-glutamyltranspeptidase-like	0	DIRECT
LysM domain	0	DIRECT
FYVE, a phosphatidylinositol-3-phosphate binding domain	0	DIRECT
Tryptophan synthase beta subunit-like PLP-dependent enzymes	0	DIRECT
Chitinase insertion domain	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
Brix domain	0	DIRECT
Mitochondrial carrier	0	DIRECT
NHL repeat	0	DIRECT
Proteasome subunits	0	DIRECT
Group II chaperonin (CCT, TRIC), ATPase domain	0	DIRECT
Group II chaperonin (CCT, TRIC), apical domain	0	DIRECT
Inositol monophosphatase/fructose-1,6-bisphosphatase-like	0	DIRECT
Ribosomal protein L18 and S11	0	DIRECT
Dual specificity phosphatase-like	0	DIRECT
SAM (sterile alpha motif) domain	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Ribokinase-like	0	DIRECT
Poly(ADP-ribose) polymerase, C-terminal domain	0	DIRECT
Nucleosome core histones	0	DIRECT
Actin/HSP70	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Intermediate filament protein, coiled coil region	0	DIRECT
Clathrin coat assembly domain	0	DIRECT
SMAD MH1 domain	0	DIRECT
Hsp90 middle domain	0	DIRECT
GAS2 domain	0	DIRECT
Lactate & malate dehydrogenases, C-terminal domain	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
Spectrin repeat	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
RecA protein-like (ATPase-domain)	0	DIRECT
Second domain of FERM	0	DIRECT
CoA-binding domain	0	DIRECT
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta	0	DIRECT
NOL1/NOP2/sun	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
IF2B-like	0	DIRECT
Cytoplasmic domain of inward rectifier potassium channel	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
LEM domain	0	DIRECT
Choline kinase	0	DIRECT
DEP domain	0	DIRECT
Double-stranded RNA-binding domain (dsRBD)	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	0	DIRECT
Citrate synthase	0	DIRECT
Pancreatic carboxypeptidases	0	DIRECT
Phosphatidylethanolamine binding protein	0	DIRECT
BAR domain	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
Histone deacetylase, HDAC	0	DIRECT
RhoGDI-like	0	DIRECT
CoA transferase alpha subunit-like	0	DIRECT
Phosphoribosyltransferases (PRTases)	0	DIRECT
Reductases	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
beta 1,4 galactosyltransferase (b4GalT1)	0	DIRECT
Insulin-like	0	DIRECT
Hedgehog C-terminal (Hog) autoprocessing domain	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
Clathrin adaptor core protein	0	DIRECT
Vertebrate phospholipase A2	0	DIRECT
TBP-associated factors, TAFs	0	DIRECT
Alcohol dehydrogenase-like, N-terminal domain	0	DIRECT
CUT domain	0	DIRECT
Sec63 N-terminal domain	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
NLI interacting factor-like phosphatase	0	DIRECT
Ferredoxin reductase FAD-binding domain-like	0	DIRECT
SWIRM domain	0	DIRECT
Translation initiation factor eIF4e	0	DIRECT
Tetraspanin	0	DIRECT
Calpain large subunit, catalytic domain (domain II)	0	DIRECT
PUA domain	0	DIRECT
YicI catalytic domain-like	0	DIRECT
alpha-Amylases, C-terminal beta-sheet domain	0	DIRECT
DNA replication initiator (cdc21/cdc54) N-terminal domain	0	DIRECT
Doublecortin (DC)	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
UBA domain	0	DIRECT
Aquaporin-like	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
PLC-like (P variant)	0	DIRECT
Carboxypeptidase regulatory domain	0	DIRECT
Myotubularin-like phosphatases	0	DIRECT
acyl-CoA oxidase C-terminal domains	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
Rap/Ran-GAP	0	DIRECT
Polo-box duplicated region	0	DIRECT
Integrin domains	0	DIRECT
PDI-like	0	DIRECT
RNA editing terminal uridyl transferase 2, RET2, domain 2	0	DIRECT
HAT/Suf repeat	0	DIRECT
Regulator of chromosome condensation RCC1	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
Ribosomal protein S18	0	DIRECT
Phosphate binding protein-like	0	DIRECT
Linker histone H1/H5	0	DIRECT
PhzC/PhzF-like	0	DIRECT
Smc hinge domain	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
Arylsulfatase	0	DIRECT
SAND domain	0	DIRECT
p120GAP domain-like	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
HD domain	0	DIRECT
Reprolysin-like	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
Phosphotyrosine-binding domain (PTB)	0	DIRECT
WGR domain	0	DIRECT
Pyk2-associated protein beta ARF-GAP domain	0	DIRECT
Calcium ATPase, transmembrane domain M	0	DIRECT
MIF4G domain-like	0	DIRECT
Glycogenin	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
L30e/L7ae ribosomal proteins	0	DIRECT
Eps15 homology domain (EH domain)	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
CAT-like	0	DIRECT
Tubulin, GTPase domain	0	DIRECT
Hydantoinase (dihydropyrimidinase)	0	DIRECT
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains	0	DIRECT
Fatty acid binding protein-like	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
DEATH domain, DD	0	DIRECT
Annexin	0	DIRECT
Class I aldolase	0	DIRECT
Erythroid transcription factor GATA-1	0	DIRECT
Cadherin	0	DIRECT
Lamin A/C globular tail domain	0	DIRECT
Lipovitellin-phosvitin complex; beta-sheet shell regions	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Sec63 C-terminal domain-like	0	DIRECT
Filamin repeat (rod domain)	0	DIRECT
Ribosomal protein L1	0	DIRECT
D-aminoacid oxidase, N-terminal domain	0	DIRECT
Peptidylglycine alpha-hydroxylating monooxygenase, PHM	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Class II glutamine amidotransferases	0	DIRECT
HEAT repeat	0	DIRECT
a tRNA synthase domain	0	DIRECT
DNA gyrase/MutL, N-terminal domain	0	DIRECT
Nop domain	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
PaaI/YdiI-like	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
Tubulin, C-terminal domain	0	DIRECT
PABC (PABP) domain	0	DIRECT
Inositol polyphosphate 5-phosphatase (IPP5)	0	DIRECT
Bactericidal permeability-increasing protein, BPI	0	DIRECT
PDZ domain	0	DIRECT
alpha-mannosidase, domain 2	0	DIRECT
Sterol carrier protein, SCP	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase Pyr module	0	DIRECT
Elafin-like	0	DIRECT
Biotinyl/lipoyl-carrier proteins and domains	0	DIRECT
14-3-3 protein	0	DIRECT
AN1-like Zinc finger	0	DIRECT
Ngr ectodomain-like	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
Aminoacid dehydrogenase-like, C-terminal domain	0	DIRECT
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Internalin LRR domain	0	DIRECT
Ubiquitin activating enzymes (UBA)	0	DIRECT
Formate/glycerate dehydrogenases, NAD-domain	0	DIRECT
GAPDH-like	0	DIRECT
1,3-glucuronyltransferase	0	DIRECT
Chaperone J-domain	0	DIRECT
Class I glutamine amidotransferases (GAT)	0	DIRECT
SCF ubiquitin ligase complex WHB domain	0	DIRECT
Phoshoinositide 3-kinase (PI3K) helical domain	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
DNA gyrase/MutL, second domain	0	DIRECT
PDEase	0	DIRECT
ATP-dependent protease Lon (La), catalytic domain	0	DIRECT
Trunk domain of Sec23/24	0	DIRECT
UDP-glucose pyrophosphorylase	0	DIRECT
Biotin dependent carboxylase carboxyltransferase domain	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
Ras-binding domain, RBD	0	DIRECT
Acyl-CoA thioesterase	0	DIRECT
Myeloperoxidase-like	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
Acireductone dioxygenase	0	DIRECT
Alcohol dehydrogenase-like, C-terminal domain	0	DIRECT
LacY-like proton/sugar symporter	0	DIRECT
Lesion bypass DNA polymerase (Y-family), catalytic domain	0	DIRECT
Pancreatic carboxypeptidase, activation domain	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
HSP20	0	DIRECT
alpha-mannosidase, C-terminal domain	0	DIRECT
RNA-polymerase beta	0	DIRECT
Phoshoinositide 3-kinase (PI3K), catalytic domain	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
Pleckstrin-homology domain (PH domain)	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase PP module	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
HCDH C-domain-like	0	DIRECT
28-residue LRR	0	DIRECT
FtsH protease domain-like	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
MFPT repeat	0	DIRECT
Subtilases	0	DIRECT
BC N-terminal domain-like	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
MIR domain	0	DIRECT
Small-conductance potassium channel	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
Arfaptin, Rac-binding fragment	0	DIRECT
Lipovitellin-phosvitin complex, superhelical domain	0	DIRECT
Third domain of FERM	0	DIRECT
BC C-terminal domain-like	0	DIRECT
YbiA-like	0	DIRECT
Glycerol kinase	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
L-aminoacid/polyamine oxidase	0	DIRECT
BEACH domain	0	DIRECT
BC ATP-binding domain-like	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
SMAD domain	0	DIRECT
Acylamino-acid-releasing enzyme, C-terminal donain	0	DIRECT
Glycerophosphoryl diester phosphodiesterase	0	DIRECT
WWE domain	0	DIRECT
Dimeric isocitrate & isopropylmalate dehydrogenases	0	DIRECT
Methionine aminopeptidase, insert domain	0	DIRECT
Anticodon-binding domain	0	DIRECT
Cullin homology domain	0	DIRECT
Tim10/DDP	0	DIRECT
Chromo domain	0	DIRECT
FF domain	0	DIRECT
t-snare proteins	0	DIRECT
Anticodon-binding domain of Class II aaRS	0	DIRECT
FHA domain	0	DIRECT
Acyl-carrier protein (ACP)	0	DIRECT
Arginine methyltransferase	0	DIRECT
Amylase, catalytic domain	0	DIRECT
PEP carboxykinase C-terminal domain	0	DIRECT
First domain of FERM	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Hormone receptor domain	0	DIRECT
ARID domain	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
La domain	0	DIRECT
Adenain-like	0	DIRECT
Cullin repeat	0	DIRECT
Heme-dependent catalases	0	DIRECT
Epoxide hydrolase	0	DIRECT
Laminin G-like module	0	DIRECT
2Fe-2S ferredoxin domains from multidomain proteins	0	DIRECT
LDH N-terminal domain-like	0	DIRECT
Inositol polyphosphate kinase (IPK)	0	DIRECT
YWTD domain	0	DIRECT
cAMP-binding domain	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Complement control module/SCR domain	0	DIRECT
Cell cycle control phosphatase, catalytic domain	0	DIRECT
ets domain	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
Glutaminase	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Mammalian PLC	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain	0	DIRECT
Translational machinery components	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
acyl-CoA oxidase N-terminal domains	0	DIRECT
Single strand DNA-binding domain, SSB	0	DIRECT
ABC transporter ATPase domain-like	0.001183	INHERITED FROM: metal response variant || RNAi response variant || colchicine hypersensitive || organism homeostasis metabolism variant || cadmium response variant || RNAi resistant
Tandem AAA-ATPase domain	0.003427	INHERITED FROM: organism stress response variant || RNAi response variant || germline RNAi resistant || organism UV response variant || DNA damage response variant || sick || organism environmental stimulus response variant
Homeodomain	0.03517	INHERITED FROM: carbon dioxide avoidance variant || ectopic expression transgene || level of transgene expression variant || organism metabolism processing variant || carbon dioxide response variant
ABC transporter transmembrane region	0.04123	INHERITED FROM: metal response variant || RNAi response variant || colchicine hypersensitive || cadmium response variant || RNAi resistant
G proteins	0.04445	INHERITED FROM: protein phosphorylation variant || pathogen release variant || carbon dioxide avoidance variant || osmotic integrity variant || aldicarb response variant || drug induced gene expression variant || chemosensory response variant || fat content variant || chemotaxis variant || chemosensory behavior variant || hermaphrodite physiology variant || sexually dimorphic physiology variant || organism metabolism processing variant || protein subcellular localization variant || bacterially unswollen || organism environmental stimulus response variant || carbon dioxide response variant
WD40-repeat	0.04457	INHERITED FROM: osmotic avoidance variant || ivermectin resistant || ivermectin response variant || protein aggregation induced behavior variant || dauer defective || antimicrobial gene expression variant
L-arabinose binding protein-like	0.05603	INHERITED FROM: cation positive chemotaxis defective || alkaline pH chemotaxis variant || magnesium chemotaxis defective || anion positive chemotaxis defective || iodide chemotaxis defective || thermosensory behavior variant || anion positive chemotaxis variant || chemosensory response variant || thermotaxis variant || cation positive chemotaxis variant || organism temperature response variant || chemotaxis variant || lithium chemotaxis defective || chemosensory behavior variant || bromide chemotaxis variant || iodide chemotaxis variant || organism environmental stimulus response variant || aqueous positive chemotaxis variant || bromide chemotaxis defective
MSP-like	0.06024	INHERITED FROM: dauer metabolism variant || dauer lifespan extended || fat content variant || dauer lifespan variant || lipid metabolism variant
Protein kinases, catalytic subunit	0.07544	INHERITED FROM: protein phosphorylation variant || alkaline pH chemotaxis variant || mechanosensation variant || oxygen response variant || metal response variant || chemical response variant || colchicine resistant || aldicarb response variant || drug induced gene expression variant || chemosensory response variant || pathogen induced gene expression variant || octanol chemotaxis defective || chemotaxis variant || conflicting sensory integration variant || kinase activity reduced || protein modification variant || egg laying response to food variant || chemosensory behavior variant || anoxia resistant || lipid synthesis increased || positive chemotaxis variant || protein subcellular localization variant || protein expression variant || second messenger mediated signaling variant || protein phosphorylation reduced
CCCH zinc finger	0.08395	INHERITED FROM: ectopic expression transgene || gene expression variant || transgene expression variant || mRNA expression ectopic
Canonical RBD	0.08683	INHERITED FROM: no induction of antimicrobial peptide expression after infection || late larval arrest || innate immune response variant || RNA expression variant || RNA processing variant || sick || mRNA export variant || organism metabolism processing variant || RNA metabolism variant || antimicrobial gene expression variant || starvation induced apoptosis variant
Extended AAA-ATPase domain	0.1016	INHERITED FROM: protein expression increased || spontaneous mutation rate increased || sick
Tetratricopeptide repeat (TPR)	0.1103	INHERITED FROM: organism metabolism processing variant
Cold shock DNA-binding domain-like	0.1254	INHERITED FROM: nonsense mRNA accumulation || mRNA surveillance defective || sick || hermaphrodite physiology variant
Adenylyl and guanylyl cyclase catalytic domain	0.1298	INHERITED FROM: cation positive chemotaxis defective || alkaline pH chemotaxis variant || magnesium chemotaxis defective || anion positive chemotaxis defective || iodide chemotaxis defective || osmotic avoidance variant || chemosensory response variant || diacetyl chemotaxis variant || cation positive chemotaxis variant || aqueous chemosensory response variant || chemotaxis variant || lithium chemotaxis defective || chemosensory behavior variant || AWC odorant chemotaxis variant || AWC odorant chemotaxis defective || positive chemotaxis variant || bromide chemotaxis variant || iodide chemotaxis variant || organism environmental stimulus response variant || bromide chemotaxis defective || second messenger mediated signaling variant || carbon dioxide response variant
Motor proteins	0.1298	INHERITED FROM: sexually dimorphic mechanosensation variant
HLH, helix-loop-helix DNA-binding domain	0.1298	INHERITED FROM: aqueous positive chemotaxis defective || ectopic expression transgene || RNA expression variant || pathogen resistance increased || fungal resistance increased || lysine chemotaxis defective || gene expression level reduced
Ankyrin repeat	0.1692	INHERITED FROM: organism heat response variant || odorant negative chemotaxis defective || octanol chemotaxis defective || octanol chemotaxis variant
Calcium ATPase, transduction domain A	0.1693	INHERITED FROM: drug hypersensitive || nicotine hypersensitive
SH3-domain	0.1764	INHERITED FROM: aldicarb response variant || protein expression reduced || protein expression variant
Class I aminoacyl-tRNA synthetases (RS), catalytic domain	0.2064	INHERITED FROM: oxygen response variant || paraquat resistant || transgene expression increased || innate immune response variant || paraquat response variant || gene expression variant || hypoxia response variant || hypoxia resistant || receptor mediated endocytosis defective || organism environmental stimulus response variant || antimicrobial gene expression variant
Elongation factors	0.2064	INHERITED FROM: protein phosphorylation variant || mRNA levels reduced || protein phosphorylation increased || protein protein interaction variant || proteasome core activity variant || mRNA levels increased || protein aggregation variant
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain	0.2064	INHERITED FROM: oxygen response variant || gene expression variant || hypoxia response variant || hypoxia resistant || receptor mediated endocytosis defective || transgene expression variant || hermaphrodite physiology variant || sexually dimorphic physiology variant || organism metabolism processing variant || organism environmental stimulus response variant || oocyte physiology variant
DBL homology domain (DH-domain)	0.2064	INHERITED FROM: pathogen resistance increased || aldicarb response variant || organism pathogen response variant || bacterially unswollen || organism environmental stimulus response variant
Cyclin	0.2064	INHERITED FROM: level of transgene expression variant
HMG-box	0.2064	INHERITED FROM: maintenance of gene silencing variant
Pepsin-like	0.2277	INHERITED FROM: transgene subcellular localization variant || protein interaction variant || osmotic integrity variant || hypoosmotic shock hypersensitive || gene expression variant || protein protein interaction variant || transgene expression variant || pattern of transgene expression variant || organism metabolism processing variant || protein aggregation variant
Histone lysine methyltransferases	0.2277	INHERITED FROM: maintenance of gene silencing variant || RNAi response variant || ectopic expression antibody || histone methylation variant || gene expression variant || mRNA expression variant || protein methylation variant || protein modification variant || shortened life span || pattern of transgene expression variant || organism metabolism processing variant || protein metabolism variant || life span variant
Forkhead DNA-binding domain	0.2514	INHERITED FROM: transgene subcellular localization variant || gene expression variant || transgene expression variant || pattern of transgene expression variant || organism metabolism processing variant
Metal cation-transporting ATPase, ATP-binding domain N	0.2514	INHERITED FROM: drug hypersensitive || nicotine hypersensitive || organism environmental stimulus response variant
Multidrug efflux transporter AcrB transmembrane domain	0.261	INHERITED FROM: odorant chemosensory response variant || odorant positive chemotaxis defective || egg integrity defective early emb || positive chemotaxis defective || embryo osmotic integrity defective early emb
Cytochrome P450	0.265	INHERITED FROM: metal response variant || metabolite content decreased || cadmium response variant
Bromodomain	0.2768	INHERITED FROM: acute functional tolerance to alcohol defective || anesthetic response variant || drug adaptation variant || ethanol resistant || organism UV response variant || gene expression variant || anesthetic resistant || sick || organism UV hypersensitive
6-phosphogluconate dehydrogenase-like, N-terminal domain	0.2768	INHERITED FROM: fat content variant || lipid metabolism variant
Acetylcholinesterase-like	0.2842	INHERITED FROM: acetylcholinesterase reduced || acetylcholinesterase activity variant || enzyme activity reduced || enzyme activity variant
FAD/NAD-linked reductases, N-terminal and central domains	0.3046	INHERITED FROM: paraquat response variant || pesticide response variant
Neurotransmitter-gated ion-channel transmembrane pore	0.3177	INHERITED FROM: mechanosensation variant || chemical response variant || slowing response on food variant || sodium chloride chemotaxis variant || nicotine resistant || thermosensory behavior variant || cholinergic agonist resistant || drug response variant || chemosensory response variant || hypoosmotic shock hypersensitive || organism temperature response variant || chemotaxis variant || antihelmintic response variant || chemosensory behavior variant || AWC odorant chemotaxis variant || positive chemotaxis variant || selenium response variant || DMPP response variant || benzaldehyde chemotaxis variant || organism environmental stimulus response variant
Meta-cation ATPase, catalytic domain P	0.3352	INHERITED FROM: nicotine hypersensitive || organism environmental stimulus response variant
Sm motif of small nuclear ribonucleoproteins, SNRNP	0.3352	INHERITED FROM: pattern protein expression variant || protein protein interaction variant || receptor mediated endocytosis defective || sick || hermaphrodite physiology variant || pattern of transgene expression variant || sexually dimorphic physiology variant || protein subcellular localization variant || life span variant || protein aggregation variant || oocyte physiology variant
Crotonase-like	0.3352	INHERITED FROM: fat content variant || lipid metabolism variant
PX domain	0.3696	INHERITED FROM: protein subcellular localization variant || protein expression variant
GABA-aminotransferase-like	0.4041	INHERITED FROM: fat content reduced
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)	0.4254	INHERITED FROM: drug resistant || organism stress response variant || thermosensory behavior variant || aldicarb response variant || drug induced gene expression variant || thermotaxis variant || organism temperature response variant || response to injury variant || nose touch variant || protein subcellular localization variant || antimicrobial gene expression variant || odorant positive chemotaxis variant
BTB/POZ domain	0.4256	INHERITED FROM: L1 arrest || early larval arrest || protein aggregation induced behavior variant || resistant to protein aggregation induced paralysis || chemical hypersensitive
FKBP immunophilin/proline isomerase	0.4452	INHERITED FROM: transgene subcellular localization variant || protein interaction variant || protein protein interaction variant || pattern of transgene expression variant || protein aggregation variant
Cation efflux protein transmembrane domain-like	0.4452	INHERITED FROM: metal response variant || manganese toxicity resistant || manganese response variant || cadmium response variant || cadmium hypersensitive
PHD domain	0.4537	INHERITED FROM: transgene subcellular localization variant || organism UV response variant || gene expression variant || transgene expression variant || protein methylation variant || protein modification variant || organism UV hypersensitive || organism metabolism processing variant || RNAi resistant || organism environmental stimulus response variant
Pyridoxal-dependent decarboxylase	0.4864	INHERITED FROM: egg laying response to drug variant || carbon dioxide avoidance variant || carbon dioxide response variant
Hect, E3 ligase catalytic domain	0.4864	INHERITED FROM: transgene subcellular localization variant || protein interaction variant || gene expression variant || protein protein interaction variant || protein aggregation induced behavior variant || transgene expression variant || cell stress response variant || pattern of transgene expression variant || organism metabolism processing variant || germ cell ionizing radiation response variant || protein aggregation variant
Myosin rod fragments	0.4864	INHERITED FROM: hermaphrodite physiology variant || sexually dimorphic physiology variant
Glutathione S-transferase (GST), N-terminal domain	0.4896	INHERITED FROM: organism stress response variant || metal response variant || organism electrophilic stress hypersensitive || paraquat response variant || organism heat hypersensitive || enzyme activity reduced || enzyme activity variant || organism environmental stimulus response variant || cadmium hypersensitive
Nicotinic receptor ligand binding domain-like	0.5135	INHERITED FROM: mechanosensation variant || chemical response variant || slowing response on food variant || sodium chloride chemotaxis variant || nicotine resistant || thermosensory behavior variant || cholinergic agonist resistant || drug response variant || chemosensory response variant || hypoosmotic shock hypersensitive || chemotaxis variant || antihelmintic response variant || chemosensory behavior variant || AWC odorant chemotaxis variant || positive chemotaxis variant || selenium response variant || DMPP response variant || benzaldehyde chemotaxis variant || organism environmental stimulus response variant
I set domains	0.5143	INHERITED FROM: aldicarb response variant || aldicarb resistant || growth rate variant || protein degradation variant
Papain-like	0.524	INHERITED FROM: protein interaction variant || osmotic integrity variant || hypoosmotic shock hypersensitive || gene expression variant || protein protein interaction variant || transgene expression variant || pattern of transgene expression variant || organism metabolism processing variant || protein aggregation variant
Calpain large subunit, middle domain (domain III)	0.535	INHERITED FROM: metabolic pathway variant || protein degradation variant || protein metabolism variant
Gastric lipase	0.535	INHERITED FROM: fat content variant || lipid metabolism variant
Myb/SANT domain	0.535	INHERITED FROM: growth rate variant
WW domain	0.5452	INHERITED FROM: maintenance of gene silencing variant
UBC-related	0.5747	INHERITED FROM: transgene subcellular localization variant || late larval arrest || protein interaction variant || gene expression variant || protein protein interaction variant || transgene expression variant || pattern of transgene expression variant || organism metabolism processing variant || protein aggregation variant
Class I alpha-1;2-mannosidase, catalytic domain	0.5833	INHERITED FROM: extended life span || protein protein interaction variant || protein aggregation variant
Synaptotagmin-like (S variant)	0.6135	INHERITED FROM: drug resistant || acetylcholinesterase inhibitor response variant || acetylcholinesterase inhibitor resistant || pattern protein expression variant || drug response variant || protein subcellular localization variant
SH2 domain	0.615	INHERITED FROM: level of protein expression variant || protein expression reduced || protein expression variant
Ubiquitin carboxyl-terminal hydrolase, UCH	0.659	INHERITED FROM: protein interaction variant || gene expression variant || protein protein interaction variant || transgene expression variant || pattern of transgene expression variant || organism metabolism processing variant || protein aggregation variant
Frizzled cysteine-rich domain	0.7002	INHERITED FROM: antibody staining variant || transgene expression reduced
Transforming growth factor (TGF)-beta	0.7002	INHERITED FROM: level of transgene expression variant || drug response variant || transgene expression reduced || nicotine response variant || levamisole response variant
EF-hand modules in multidomain proteins	0.7002	INHERITED FROM: cell stress response variant || protein expression variant
Ubiquitin-related	0.7403	INHERITED FROM: protein interaction variant || protein protein interaction variant || transgene expression variant || hypersensitive to protein aggregation induced paralysis || protein aggregation variant
H-NOX domain	0.7658	INHERITED FROM: carbon dioxide avoidance variant || carbon dioxide response variant
Cdc48 N-terminal domain-like	0.7658	INHERITED FROM: protein interaction variant || protein protein interaction variant || metabolic pathway variant || protein metabolism variant || transgene expression reduced || protein aggregation variant
Hemocyanin middle domain	0.7658	INHERITED FROM: organism stress response variant || organism ionizing radiation response variant || cell stress response variant || cell ionizing radiation response variant || germ cell ionizing radiation response variant
Bacterial lipase	0.7658	INHERITED FROM: fat content variant || lipid metabolism variant
MIT domain	0.7658	INHERITED FROM: protein interaction variant || protein protein interaction variant || protein aggregation variant
Voltage-gated potassium channels	0.7843	INHERITED FROM: serotonin response variant || serotonin resistant || adrenergic receptor antagonist response variant || growth rate variant || protein degradation variant
AAT-like	0.8366	INHERITED FROM: growth rate variant
LIM domain	0.8366	INHERITED FROM: level of protein expression variant || protein expression reduced || protein degradation variant
Cyclophilin (peptidylprolyl isomerase)	0.8579	INHERITED FROM: transgene subcellular localization variant || protein interaction variant || protein protein interaction variant || transgene expression variant || pattern of transgene expression variant || protein aggregation variant
DnaQ-like 3'-5' exonuclease	0.8824	INHERITED FROM: RNAi response variant
Glutathione S-transferase (GST), C-terminal domain	0.8854	INHERITED FROM: organism stress response variant || organism electrophilic stress hypersensitive || organism heat hypersensitive || enzyme activity reduced || enzyme activity variant || cadmium hypersensitive
Calmodulin-like	0.8954	INHERITED FROM: protein interaction variant || protein protein interaction variant || protein aggregation variant
Leucine zipper domain	0.8965	INHERITED FROM: mRNA levels reduced || pathogen susceptibility increased || level of transgene expression variant || pore forming toxin response variant || transgene expression reduced
SNF-like	0.9079	INHERITED FROM: drug hypersensitive
Extended PAW domain	0.9079	INHERITED FROM: transgene subcellular localization variant || protein interaction variant || protein protein interaction variant || pattern of transgene expression variant || protein aggregation variant
Ribonuclease PH domain 1-like	0.9436	INHERITED FROM: early larval arrest
Ribonuclease PH domain 2-like	0.9436	INHERITED FROM: early larval arrest
NagD-like	0.9436	INHERITED FROM: dauer formation variant || dauer constitutive
Choline/Carnitine O-acyltransferase	0.9945	INHERITED FROM: fat content variant || lipid metabolism variant
RING finger domain, C3HC4	1	INHERITED FROM: transgene subcellular localization variant || protein interaction variant || protein protein interaction variant || pattern of transgene expression variant || organism metabolism processing variant || germ cell hypersensitive ionizing radiation || germ cell ionizing radiation response variant || protein aggregation variant
PAZ domain	1	INHERITED FROM: maintenance of gene silencing variant || RNAi response variant || RNA expression variant || RNAi enhanced || 21U RNA expression variant || mRNA levels increased || siRNA expression variant
F-box domain	1	INHERITED FROM: protein aggregation induced behavior variant || resistant to protein aggregation induced paralysis
Nuclear receptor ligand-binding domain	1	INHERITED FROM: SDS sensitive dauer || dauer resistance to harsh conditions variant || gene expression level high || fat content increased || gene expression level reduced || transgene expression reduced
B-box zinc-binding domain	1	INHERITED FROM: transgene subcellular localization variant || protein interaction variant || gene expression variant || protein protein interaction variant || transgene expression variant || protein aggregation variant
Glutathione peroxidase-like	1	INHERITED FROM: paraquat response variant || pesticide response variant
Rhodopsin-like	1	INHERITED FROM: egg laying response to drug variant || serotonin response variant || drug withdrawal response variant || serotonin resistant || biogenic amine receptor antagonist resistant || aqueous adaptation defective || male tail curling serotonin variant || serotonin hypersensitive || organism pathogen response variant || serotonin induced fat reduction variant || locomotion rate serotonin variant || serotonin induced pumping variant
N-acetyl transferase, NAT	1	INHERITED FROM: ectopic expression transgene
Nuclear receptor	1	INHERITED FROM: SDS sensitive dauer || dauer resistance to harsh conditions variant || gene expression level high || fat content increased || gene expression level reduced || transgene expression reduced