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Worm Phenotype (WP): organism physiology variant

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Variant [WBPhenotype:0000886] <5>
+ 1:   physiology variant [WBPhenotype:0000519] <6>(500|576) (501|250|69)
0:   organism physiology variant [WBPhenotype:0000576] <10>(346|416) (350|194|57)
- 1:   organism homeostasis metabolism variant [WBPhenotype:0000577] <17>(336|405) (340|192|57)
- 1:   dauer arrest variant [WBPhenotype:0000159] <6>(10|12) (10|7|0)
- 1:   life span variant [WBPhenotype:0000039] <5>(27|30) (28|15|5)
- 1:   aging variant [WBPhenotype:0001739] <3>(1|0) (1|0|0)
- 1:   genetic pathway variant [WBPhenotype:0000074] <2>(0|0) (0|0|0)
- 1:   sexually dimorphic physiology variant [WBPhenotype:0000889] <2>(1|1) (1|0|0)
- 1:   heteroplasmy [WBPhenotype:0002121] <1>(0|0) (0|0|0)
- 1:   growth defective on low phosphate media [WBPhenotype:0002235](0|0) (0|0|0)
- 1:   larval physiology variant [WBPhenotype:0001293](0|0) (0|0|0)
- 1:   subviable [WBPhenotype:0002116](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Rap/Ran-GAP0Direct
Spectrin repeat0Direct
SAND domain-like0Direct
GHMP Kinase, C-terminal domain0Direct
Thyroglobulin type-1 domain0Direct
SMAD/FHA domain0Direct
PurM N-terminal domain-like0Direct
YbiA-like0Direct
SWIB/MDM2 domain0Direct
Lamin A/C globular tail domain0Direct
TGS-like0Direct
Skp1 dimerisation domain-like0Direct
Rudiment single hybrid motif0Direct
L30e-like0Direct
CRAL/TRIO N-terminal domain0Direct
Ribosomal L27 protein-like0Direct
Putative DNA-binding domain0Direct
ThrRS/AlaRS common domain0Direct
Pepsin inhibitor-30Direct
Carboxypeptidase regulatory domain-like0Direct
lambda repressor-like DNA-binding domains0Direct
Succinyl-CoA synthetase domains0Direct
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)0Direct
Fibrinogen C-terminal domain-like0Direct
DEATH domain0Direct
PABC (PABP) domain0Direct
Integrin domains0Direct
Chaperone J-domain0Direct
Diaminopimelate epimerase-like0Direct
Integrin alpha N-terminal domain0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
YWTD domain0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Sec7 domain0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
Purine and uridine phosphorylases0Direct
alpha/beta knot0Direct
Ribosomal protein L10-like0Direct
Actin-like ATPase domain0Direct
MIR domain0Direct
Transducin (alpha subunit), insertion domain0Direct
Intermediate filament protein, coiled coil region0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Creatinase/prolidase N-terminal domain0Direct
Transducin (heterotrimeric G protein), gamma chain0Direct
Polo-box domain0Direct
Second domain of FERM0Direct
MOSC N-terminal domain-like0Direct
ValRS/IleRS/LeuRS editing domain0Direct
S-adenosylmethionine synthetase0Direct
CBD9-like0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
GINS helical bundle-like0Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0Direct
Formate/glycerate dehydrogenase catalytic domain-like0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
GroEL apical domain-like0Direct
HSP40/DnaJ peptide-binding domain0Direct
Cation efflux protein cytoplasmic domain-like0Direct
Proton glutamate symport protein0Direct
Aquaporin-like0Direct
Ran binding protein zinc finger-like0Direct
SAICAR synthase-like0Direct
HSP20-like chaperones0Direct
Calcium-dependent phosphotriesterase0Direct
Periplasmic binding protein-like II0Direct
RBP11-like subunits of RNA polymerase0Direct
PHM/PNGase F0Direct
Phosphoglucomutase, C-terminal domain0Direct
Tubulin nucleotide-binding domain-like0Direct
BEACH domain0Direct
PAP/OAS1 substrate-binding domain0Direct
PLC-like phosphodiesterases0Direct
Molybdenum cofactor-binding domain0Direct
AN1-like Zinc finger0Direct
Nucleotidyltransferase0Direct
F1F0 ATP synthase subunit C0Direct
Bacterial exopeptidase dimerisation domain0Direct
Hypothetical protein c14orf129, hspc2100Direct
LEM domain0Direct
Domain of poly(ADP-ribose) polymerase0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
Tubulin C-terminal domain-like0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
Cytochrome c0Direct
ENTH/VHS domain0Direct
Phosphoenolpyruvate/pyruvate domain0Direct
Tubby C-terminal domain-like0Direct
Acetyl-CoA synthetase-like0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Cadherin-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
ALDH-like0Direct
Clc chloride channel0Direct
Doublecortin (DC)0Direct
Ribosomal proteins S24e, L23 and L15e0Direct
Band 7/SPFH domain0Direct
Smc hinge domain0Direct
Ferritin-like0Direct
Elafin-like0Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0Direct
ADP-ribosylation0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Galactose oxidase, central domain0Direct
WGR domain-like0Direct
Outer arm dynein light chain 10Direct
GroEL-intermediate domain like0Direct
PEP carboxykinase-like0Direct
HCP-like0Direct
LDH C-terminal domain-like0Direct
Sec63 N-terminal domain-like0Direct
Blood coagulation inhibitor (disintegrin)0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
Ribosomal protein S180Direct
Mitochondrial carrier0Direct
Phosphoglucomutase, first 3 domains0Direct
PAP/Archaeal CCA-adding enzyme, C-terminal domain0Direct
Troponin coil-coiled subunits0Direct
LysM domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Annexin0Direct
Translational machinery components0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
PurM C-terminal domain-like0Direct
Type II DNA topoisomerase0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
Alpha-L RNA-binding motif0Direct
WWE domain0Direct
Aldolase0Direct
Cullin repeat-like0Direct
GroEL equatorial domain-like0Direct
Tricorn protease domain 20Direct
Chromo domain-like0Direct
Hedgehog/intein (Hint) domain0Direct
Subtilisin-like0Direct
Heme-dependent peroxidases0Direct
SIS domain0Direct
Zn-binding ribosomal proteins0Direct
FF domain0Direct
Terpenoid synthases0Direct
MgtE membrane domain-like0Direct
Single hybrid motif0Direct
ARID-like0Direct
3-carboxy-cis,cis-mucoante lactonizing enzyme0Direct
Class I glutamine amidotransferase-like0Direct
VPS9 domain0Direct
SCP-like0Direct
GroES-like0Direct
Cullin homology domain0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Cdc48 domain 2-like0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
Tim10-like0Direct
Citrate synthase0Direct
Class II aaRS ABD-related0Direct
PGBD-like0Direct
PreATP-grasp domain0Direct
Zn-finger domain of Sec23/240Direct
Activating enzymes of the ubiquitin-like proteins0Direct
ISP domain0Direct
Terpenoid cyclases/Protein prenyltransferases0Direct
Kringle-like0Direct
Protease propeptides/inhibitors0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
eIF4e-like0Direct
Surp module (SWAP domain)0Direct
MFPT repeat-like0Direct
PIN domain-like0Direct
Thiolase-like0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
DNA repair protein MutS, domain III0Direct
Pentein0Direct
PEBP-like0Direct
Acid phosphatase/Vanadium-dependent haloperoxidase0Direct
FAD-dependent thiol oxidase0Direct
Radical SAM enzymes0Direct
alpha-catenin/vinculin-like0Direct
CAD & PB1 domains0Direct
TK C-terminal domain-like0Direct
Oxysterol-binding protein-like0Direct
Hormone receptor domain0Direct
ClpP/crotonase0Direct
Cu,Zn superoxide dismutase-like0Direct
Restriction endonuclease-like0Direct
HMG-box0Direct
Glycolipid transfer protein, GLTP0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Nop domain0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
GAT-like domain0Direct
Clathrin adaptor appendage domain0Direct
GYF domain0Direct
PUA domain-like0Direct
PYP-like sensor domain (PAS domain)0Direct
SMAD MH1 domain0Direct
Ribosomal protein L10Direct
dsRNA-binding domain-like0Direct
Ribokinase-like0Direct
Profilin (actin-binding protein)0Direct
Chitinase insertion domain0Direct
PLP-binding barrel0Direct
Lipase/lipooxygenase domain (PLAT/LH2 domain)0Direct
Hect, E3 ligase catalytic domain0Direct
HSP90 C-terminal domain0Direct
14-3-3 protein0Direct
Composite domain of metallo-dependent hydrolases0Direct
PK beta-barrel domain-like0Direct
beta-lactamase/transpeptidase-like0Direct
Carbon-nitrogen hydrolase0Direct
CO dehydrogenase ISP C-domain like0Direct
Nucleoporin domain0Direct
PEP carboxykinase N-terminal domain0Direct
ACP-like0Direct
cAMP-binding domain-like0Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0Direct
JAB1/MPN domain0Direct
Heme-dependent catalase-like0Direct
L-aspartase-like0Direct
Helical domain of Sec23/240Direct
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase0Direct
FtsH protease domain-like0Direct
Ribosomal protein S100Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
Arginase/deacetylase0Direct
Sec1/munc18-like (SM) proteins0Direct
GAS2 domain-like0Direct
Small-conductance potassium channel0Direct
2Fe-2S ferredoxin-like0Direct
Nucleoside diphosphate kinase, NDK0Direct
SPOC domain-like0Direct
R3H domain0Direct
Cystatin/monellin0Direct
ArfGap/RecO-like zinc finger0Direct
P-loop containing nucleoside triphosphate hydrolases0.0000001671Direct
Histone-fold0.0001353Direct
PH domain-like0.0003543Direct
Protein kinase-like (PK-like)0.008045Inherited
PDZ domain-like0.01183Inherited
WD40 repeat-like0.01571Inherited
TPR-like0.01882Inherited
Nucleic acid-binding proteins0.01892Inherited
Periplasmic binding protein-like I0.02016Inherited
"Winged helix" DNA-binding domain0.02296Inherited
PapD-like0.0302Inherited
SH2 domain0.04677Inherited
Homeodomain-like0.06842Inherited
CCCH zinc finger0.07863Inherited
Cyclin-like0.07863Inherited
EGF/Laminin0.08316Inherited
ARM repeat0.1009Inherited
Translation proteins0.1069Inherited
Ankyrin repeat0.1073Inherited
Galactose-binding domain-like0.1111Inherited
HLH, helix-loop-helix DNA-binding domain0.1312Inherited
ABC transporter transmembrane region0.1312Inherited
Nucleotide cyclase0.1312Inherited
RNI-like0.1359Inherited
Calcium ATPase, transmembrane domain M0.1449Inherited
Regulator of G-protein signaling, RGS0.1603Inherited
Acyl-CoA dehydrogenase NM domain-like0.1603Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.1603Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.1603Inherited
Calcium ATPase, transduction domain A0.1774Inherited
Class II aaRS and biotin synthetases0.1774Inherited
DBL homology domain (DH-domain)0.1959Inherited
Quinoprotein alcohol dehydrogenase-like0.1959Inherited
Multidrug efflux transporter AcrB transmembrane domain0.2121Inherited
Cytochrome P4500.2431Inherited
Multidrug resistance efflux transporter EmrE0.264Inherited
BRCT domain0.2676Inherited
Cysteine proteinases0.2877Inherited
Bromodomain0.2899Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.2899Inherited
POZ domain0.292Inherited
SAM/Pointed domain0.3041Inherited
Nucleotidylyl transferase0.3085Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.3095Inherited
SNARE-like0.3187Inherited
SH3-domain0.3255Inherited
Lipocalins0.3313Inherited
Ribosomal protein S5 domain 2-like0.3635Inherited
Nicotinic receptor ligand binding domain-like0.3683Inherited
Translation proteins SH3-like domain0.3853Inherited
Cation efflux protein transmembrane domain-like0.3853Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3935Inherited
Acid proteases0.4086Inherited
E set domains0.4119Inherited
FYVE/PHD zinc finger0.4306Inherited
Cysteine-rich domain0.4321Inherited
Ubiquitin-like0.4441Inherited
RNA-binding domain, RBD0.4442Inherited
HAD-like0.4483Inherited
PRTase-like0.5098Inherited
DHS-like NAD/FAD-binding domain0.5098Inherited
Myosin rod fragments0.5098Inherited
Voltage-gated potassium channels0.5282Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.5569Inherited
Riboflavin synthase domain-like0.5569Inherited
WW domain0.5613Inherited
Sm-like ribonucleoproteins0.5613Inherited
Cystine-knot cytokines0.5613Inherited
FAD-linked reductases, C-terminal domain0.5613Inherited
FAD/NAD(P)-binding domain0.5919Inherited
SET domain0.6028Inherited
Seven-hairpin glycosidases0.6086Inherited
MFS general substrate transporter0.6146Inherited
Rhodanese/Cell cycle control phosphatase0.6296Inherited
Clavaminate synthase-like0.6414Inherited
KA1-like0.6651Inherited
Lipovitellin-phosvitin complex, superhelical domain0.6651Inherited
Osmotin, thaumatin-like protein0.6651Inherited
Nucleotide-binding domain0.6651Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.6651Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.7171Inherited
S15/NS1 RNA-binding domain0.7279Inherited
GST C-terminal domain-like0.7491Inherited
Ribonuclease H-like0.7493Inherited
alpha/beta-Hydrolases0.7633Inherited
PAZ domain0.7751Inherited
ADC-like0.7946Inherited
MIT domain0.7946Inherited
UBC-like0.8315Inherited
Fibronectin type III0.8381Inherited
EF-hand0.888Inherited
Leucine zipper domain0.8929Inherited
UBA-like0.893Inherited
CoA-dependent acyltransferases0.9296Inherited
p53-like transcription factors0.9593Inherited
Ribonuclease PH domain 2-like0.969Inherited
Immunoglobulin0.9817Inherited
Nuclear receptor ligand-binding domain0.9875Inherited
beta-beta-alpha zinc fingers0.9878Inherited
Cyclophilin-like1Inherited
Ligand-binding domain in the NO signalling and Golgi transport1Inherited
B-box zinc-binding domain1Inherited
RING/U-box1Inherited
Insulin-like1Inherited
Saposin1Inherited
Thioredoxin-like1Inherited
FKBP-like1Inherited
Eukaryotic type KH-domain (KH-domain type I)1Inherited
F-box domain1Inherited
Family A G protein-coupled receptor-like1Inherited
Bet v1-like1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Cullin repeat0Direct
Nucleosome core histones0Direct
Regulator of chromosome condensation RCC10Direct
Thiolase-related0Direct
First domain of FERM0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain0Direct
Pancreatic carboxypeptidases0Direct
D-aminoacid oxidase-like0Direct
Succinyl-CoA synthetase domains0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Nucleoside diphosphate kinase, NDK0Direct
Ras-binding domain, RBD0Direct
Ribokinase-like0Direct
AAT-like0Direct
Amylase, catalytic domain0Direct
Tandem AAA-ATPase domain0Direct
Reprolysin-like0Direct
Myotubularin-like phosphatases0Direct
Sir2 family of transcriptional regulators0Direct
Ubiquitin activating enzymes (UBA)0Direct
beta-Lactamase/D-ala carboxypeptidase0Direct
BC C-terminal domain-like0Direct
Proteasome subunits0Direct
Proprotein convertase P-domain0Direct
COMT-like0Direct
Thyroglobulin type-1 domain0Direct
Mammalian PLC0Direct
PurM C-terminal domain-like0Direct
PurM N-terminal domain-like0Direct
Proton glutamate symport protein0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)0Direct
Phosphoglucomutase, first 3 domains0Direct
Tubulin, C-terminal domain0Direct
GYF domain0Direct
Ribosomal protein S180Direct
D-aminoacid oxidase, N-terminal domain0Direct
Bacterial exopeptidase dimerisation domain0Direct
Branched-chain alpha-keto acid dehydrogenase PP module0Direct
Phosphotyrosine-binding domain (PTB)0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
UDP-glucose pyrophosphorylase0Direct
PDZ domain0Direct
Poly(A) polymerase, PAP, C-terminal domain0Direct
LDH N-terminal domain-like0Direct
Lactate & malate dehydrogenases, C-terminal domain0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Cofilin-like0Direct
Sterol carrier protein, SCP0Direct
L30e/L7ae ribosomal proteins0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Glutaminase0Direct
RNA-polymerase beta0Direct
Brix domain0Direct
Anticodon-binding domain0Direct
beta-sandwich domain of Sec23/240Direct
AN1-like Zinc finger0Direct
Acetyl-CoA synthetase-like0Direct
PEP carboxykinase C-terminal domain0Direct
ALDH-like0Direct
HSP200Direct
Tim10/DDP0Direct
Aquaporin-like0Direct
Erythroid transcription factor GATA-10Direct
Hydantoinase (dihydropyrimidinase)0Direct
Acylamino-acid-releasing enzyme, C-terminal donain0Direct
Reductases0Direct
Band 7/SPFH domain0Direct
Elafin-like0Direct
MOSC N-terminal domain-like0Direct
Hydantoinase (dihydropyrimidinase), catalytic domain0Direct
Poly(A) polymerase, PAP, middle domain0Direct
Adenosine/AMP deaminase0Direct
LacY-like proton/sugar symporter0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Transducin (alpha subunit), insertion domain0Direct
Doublecortin (DC)0Direct
Ran binding protein zinc finger-like0Direct
Clathrin coat assembly domain0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
POU-specific domain0Direct
DEATH domain, DD0Direct
PABC (PABP) domain0Direct
FAD-dependent thiol oxidase0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
Inositol polyphosphate kinase (IPK)0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain0Direct
Sec63 N-terminal domain0Direct
PDEase0Direct
Group II chaperonin (CCT, TRIC), apical domain0Direct
MIR domain0Direct
VHS domain0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
BEACH domain0Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
Chromo domain0Direct
Spectrin repeat0Direct
Choline kinase0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
SCF ubiquitin ligase complex WHB domain0Direct
Quinoprotein alcohol dehydrogenase-like0Direct
RNA-polymerase beta-prime0Direct
DPP6 catalytic domain-like0Direct
Bactericidal permeability-increasing protein, BPI0Direct
Blood coagulation inhibitor (disintegrin)0Direct
Clc chloride channel0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Ribonucleotide reductase-like0Direct
YbiA-like0Direct
Calpain large subunit, catalytic domain (domain II)0Direct
Ovomucoid domain III-like0Direct
Matrix metalloproteases, catalytic domain0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Biotinyl/lipoyl-carrier proteins and domains0Direct
Acireductone dioxygenase0Direct
Hsp90 middle domain0Direct
CoA-binding domain0Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0Direct
Actin/HSP700Direct
HSP90 C-terminal domain0Direct
YicI catalytic domain-like0Direct
Pepsin inhibitor-30Direct
Regulator of G-protein signaling, RGS0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
GAS2 domain0Direct
PEP carboxykinase N-terminal domain0Direct
Protein prenyltransferases0Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0Direct
Class I glutamine amidotransferases (GAT)0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
PDI-like0Direct
Fatty acid binding protein-like0Direct
Ribosomal protein L10Direct
Sec1/munc18-like (SM) proteins0Direct
XPF/Rad1/Mus81 nuclease0Direct
Peptidylglycine alpha-hydroxylating monooxygenase, PHM0Direct
Second domain of FERM0Direct
SWIRM domain0Direct
DPP6 N-terminal domain-like0Direct
Ribosomal protein L18 and S110Direct
Purine and uridine phosphorylases0Direct
RhoGDI-like0Direct
Glycerol kinase0Direct
Arylsulfatase0Direct
Molybdenum cofactor-binding domain0Direct
Arginine methyltransferase0Direct
Tetraspanin0Direct
a tRNA synthase domain0Direct
Clathrin adaptor core protein0Direct
Trunk domain of Sec23/240Direct
Hedgehog C-terminal (Hog) autoprocessing domain0Direct
YihX-like0Direct
5' to 3' exonuclease catalytic domain0Direct
PhzC/PhzF-like0Direct
FF domain0Direct
Profilin (actin-binding protein)0Direct
FHA domain0Direct
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0Direct
Heme-dependent catalases0Direct
U-box0Direct
DEP domain0Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0Direct
HAT/Suf repeat0Direct
FtsH protease domain-like0Direct
Poly(ADP-ribose) polymerase, C-terminal domain0Direct
Hypothetical protein c14orf129, hspc2100Direct
Hormone receptor domain0Direct
28-residue LRR0Direct
Gamma-glutamyltranspeptidase-like0Direct
MFPT repeat0Direct
Poly(A) polymerase, PAP, N-terminal domain0Direct
alpha-catenin/vinculin0Direct
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain0Direct
Translational machinery components0Direct
IF2B-like0Direct
Nop domain0Direct
Glycerophosphoryl diester phosphodiesterase0Direct
Tubulin, GTPase domain0Direct
LysM domain0Direct
NHL repeat0Direct
Small-conductance potassium channel0Direct
Calcium ATPase, transmembrane domain M0Direct
Cation efflux protein cytoplasmic domain-like0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
HEAT repeat0Direct
Sec63 C-terminal domain-like0Direct
Transducin (heterotrimeric G protein), gamma chain0Direct
AlkB-like0Direct
GAPDH-like0Direct
Myeloperoxidase-like0Direct
14-3-3 protein0Direct
Glycosyl transferases group 10Direct
CO dehydrogenase flavoprotein N-terminal domain-like0Direct
GHMP Kinase, N-terminal domain0Direct
CAT-like0Direct
Fibrinogen C-terminal domain-like0Direct
Helical domain of Sec23/240Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
ARID domain0Direct
RNA editing terminal uridyl transferase 2, RET2, domain 20Direct
Hect, E3 ligase catalytic domain0Direct
Linker histone H1/H50Direct
CUT domain0Direct
Third domain of FERM0Direct
Rap/Ran-GAP0Direct
LEM domain0Direct
Laminin G-like module0Direct
DNA repair protein MutS, domain III0Direct
Pancreatic carboxypeptidase, activation domain0Direct
WGR domain0Direct
Cadherin0Direct
Zn-finger domain of Sec23/240Direct
HMG-box0Direct
Lesion bypass DNA polymerase (Y-family), catalytic domain0Direct
Double-stranded RNA-binding domain (dsRBD)0Direct
Single strand DNA-binding domain, SSB0Direct
Adenain-like0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Methionine aminopeptidase, insert domain0Direct
UBA domain0Direct
L-aminoacid/polyamine oxidase0Direct
Annexin0Direct
Cyclin0Direct
BC N-terminal domain-like0Direct
Cu,Zn superoxide dismutase-like0Direct
S-adenosylmethionine synthetase0Direct
HSP40/DnaJ peptide-binding domain0Direct
Subtilases0Direct
SMAD MH1 domain0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
HD domain0Direct
Type II chitinase0Direct
Troponin I0Direct
1,3-glucuronyltransferase0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Class I aldolase0Direct
HCDH C-domain-like0Direct
Histone deacetylase, HDAC0Direct
CO dehydrogenase ISP C-domain like0Direct
PUA domain0Direct
MIF4G domain-like0Direct
Pyk2-associated protein beta ARF-GAP domain0Direct
BC ATP-binding domain-like0Direct
RecA protein-like (ATPase-domain)0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
EGF-type module0Direct
ATP-dependent protease Lon (La), catalytic domain0Direct
Phosphatidylethanolamine binding protein0Direct
Alcohol dehydrogenase-like, N-terminal domain0Direct
YWTD domain0Direct
Cullin homology domain0Direct
Translation initiation factor eIF4e0Direct
WWE domain0Direct
Armadillo repeat0Direct
ets domain0Direct
Type II DNA topoisomerase0Direct
Mitochondrial carrier0Direct
Biotin dependent carboxylase carboxyltransferase domain0Direct
beta 1,4 galactosyltransferase (b4GalT1)0Direct
Class II glutamine amidotransferases0Direct
DNA gyrase/MutL, N-terminal domain0Direct
SAND domain0Direct
Ngr ectodomain-like0Direct
Group II chaperonin (CCT, TRIC), ATPase domain0Direct
Glycolipid transfer protein, GLTP0Direct
Integrin domains0Direct
Lamin A/C globular tail domain0Direct
NTF2-like0Direct
NOL1/NOP2/sun0Direct
BAR domain0Direct
Acyl-carrier protein (ACP)0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
Arfaptin, Rac-binding fragment0Direct
2Fe-2S ferredoxin domains from multidomain proteins0Direct
Pleckstrin-homology domain (PH domain)0Direct
Internalin LRR domain0Direct
Phosphate binding protein-like0Direct
Cell cycle control phosphatase, catalytic domain0Direct
SMAD domain0Direct
Alcohol dehydrogenase-like, C-terminal domain0Direct
Formate/glycerate dehydrogenases, NAD-domain0Direct
Aminoacid dehydrogenase-like, C-terminal domain0Direct
Epoxide hydrolase0Direct
Intermediate filament protein, coiled coil region0Direct
Sec7 domain0Direct
Surp module (SWAP domain)0Direct
Cytoplasmic domain of inward rectifier potassium channel0Direct
SAM (sterile alpha motif) domain0Direct
Acyl-CoA thioesterase0Direct
Smc hinge domain0Direct
Branched-chain alpha-keto acid dehydrogenase Pyr module0Direct
Oxysterol-binding protein0Direct
Carboxypeptidase regulatory domain0Direct
Glycogenin0Direct
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta0Direct
acyl-CoA oxidase N-terminal domains0Direct
Anticodon-binding domain of Class II aaRS0Direct
Crotonase-like0Direct
cAMP-binding domain0Direct
acyl-CoA oxidase C-terminal domains0Direct
Chitinase insertion domain0Direct
Phosphoribosyltransferases (PRTases)0Direct
CRAL/TRIO N-terminal domain0Direct
MutT-like0Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
DNA gyrase/MutL, second domain0Direct
PLC-like (P variant)0Direct
Hexokinase0Direct
Skp1 dimerisation domain-like0Direct
La domain0Direct
Domain of poly(ADP-ribose) polymerase0Direct
SWIB/MDM2 domain0Direct
PaaI/YdiI-like0Direct
AMPK-beta glycogen binding domain-like0Direct
Paired domain0Direct
Citrate synthase0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
Cdc48 domain 2-like0Direct
Chaperone J-domain0Direct
Polo-box duplicated region0Direct
Ribosomal protein S100Direct
F1F0 ATP synthase subunit C0Direct
WD40-repeat0.01039Inherited
Protein kinases, catalytic subunit0.01812Inherited
G proteins0.03648Inherited
Homeodomain0.03944Inherited
ABC transporter ATPase domain-like0.03984Inherited
MSP-like0.0651Inherited
L-arabinose binding protein-like0.06951Inherited
CCCH zinc finger0.09263Inherited
Tetratricopeptide repeat (TPR)0.1284Inherited
Cold shock DNA-binding domain-like0.1484Inherited
HLH, helix-loop-helix DNA-binding domain0.1609Inherited
Adenylyl and guanylyl cyclase catalytic domain0.1609Inherited
Ankyrin repeat0.1704Inherited
Canonical RBD0.1771Inherited
Calcium ATPase, transduction domain A0.1967Inherited
ABC transporter transmembrane region0.2155Inherited
DBL homology domain (DH-domain)0.2156Inherited
Extended PAW domain0.2363Inherited
Histone lysine methyltransferases0.2363Inherited
Elongation factors0.2363Inherited
Pepsin-like0.2363Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.2363Inherited
Acetylcholinesterase-like0.2544Inherited
Dual specificity phosphatase-like0.259Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.2832Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.2832Inherited
Multidrug efflux transporter AcrB transmembrane domain0.304Inherited
6-phosphogluconate dehydrogenase-like, N-terminal domain0.3095Inherited
Bromodomain0.3095Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.3095Inherited
FYVE, a phosphatidylinositol-3-phosphate binding domain0.3095Inherited
Cytochrome P4500.3221Inherited
Extended AAA-ATPase domain0.3384Inherited
FAD/NAD-linked reductases, N-terminal and central domains0.3394Inherited
Meta-cation ATPase, catalytic domain P0.3714Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP0.3714Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3993Inherited
SH3-domain0.4034Inherited
Pumilio repeat0.442Inherited
Nicotinic receptor ligand binding domain-like0.4711Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.4759Inherited
Glutathione S-transferase (GST), N-terminal domain0.4805Inherited
GABA-aminotransferase-like0.4832Inherited
Cation efflux protein transmembrane domain-like0.4832Inherited
PHD domain0.5045Inherited
Pyridoxal-dependent decarboxylase0.5265Inherited
Myosin rod fragments0.5265Inherited
I set domains0.5683Inherited
Myb/SANT domain0.5756Inherited
Gastric lipase0.5756Inherited
Papain-like0.5849Inherited
WW domain0.5973Inherited
Class I alpha-1;2-mannosidase, catalytic domain0.6235Inherited
UBC-related0.6378Inherited
Ubiquitin carboxyl-terminal hydrolase, UCH0.6647Inherited
Synaptotagmin-like (S variant)0.6663Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.6794Inherited
Lipovitellin-phosvitin complex, superhelical domain0.6794Inherited
Osmotin, thaumatin-like protein0.6794Inherited
Growth factor receptor domain0.7Inherited
BTB/POZ domain0.701Inherited
Transforming growth factor (TGF)-beta0.7388Inherited
Voltage-gated potassium channels0.7574Inherited
Ubiquitin-related0.8028Inherited
MIT domain0.8028Inherited
H-NOX domain0.8028Inherited
Cdc48 N-terminal domain-like0.8028Inherited
Bacterial lipase0.8028Inherited
FAD-linked reductases, N-terminal domain0.8431Inherited
PAZ domain0.8664Inherited
LIM domain0.8801Inherited
Glutathione S-transferase (GST), C-terminal domain0.8937Inherited
Nuclear receptor ligand-binding domain0.9161Inherited
Leucine zipper domain0.9255Inherited
DnaQ-like 3'-5' exonuclease0.9284Inherited
Calmodulin-like0.9435Inherited
NagD-like0.9794Inherited
Ribonuclease PH domain 2-like0.9794Inherited
Ribonuclease PH domain 1-like0.9794Inherited
N-acetyl transferase, NAT1Inherited
Rhodopsin-like1Inherited
Glutathione peroxidase-like1Inherited
Eukaryotic type KH-domain (KH-domain type I)1Inherited
Insulin-like1Inherited
Cyclophilin (peptidylprolyl isomerase)1Inherited
F-box domain1Inherited
B-box zinc-binding domain1Inherited
RING finger domain, C3HC41Inherited
Choline/Carnitine O-acyltransferase1Inherited
Nuclear receptor1Inherited
FKBP immunophilin/proline isomerase1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
PYP-like sensor domain (PAS domain)0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Radical SAM enzymes0Direct
MgtE membrane domain-like0Direct
DNA repair protein MutS, domain III0Direct
GINS helical bundle-like0Direct
Molybdenum cofactor-binding domain0Direct
Restriction endonuclease-like0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
PEBP-like0Direct
Galactose oxidase, central domain0Direct
PLC-like phosphodiesterases0Direct
VPS9 domain0Direct
Troponin coil-coiled subunits0Direct
GHMP Kinase, C-terminal domain0Direct
SMAD MH1 domain0Direct
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)0Direct
SPOC domain-like0Direct
Domain of poly(ADP-ribose) polymerase0Direct
Transducin (heterotrimeric G protein), gamma chain0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
alpha/beta knot0Direct
GroEL equatorial domain-like0Direct
Terpenoid cyclases/Protein prenyltransferases0Direct
Pentein0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
Skp1 dimerisation domain-like0Direct
Ran binding protein zinc finger-like0Direct
Carbon-nitrogen hydrolase0Direct
SWIB/MDM2 domain0Direct
Rap/Ran-GAP0Direct
ThrRS/AlaRS common domain0Direct
Aquaporin-like0Direct
Pepsin inhibitor-30Direct
Purine and uridine phosphorylases0Direct
Aldolase0Direct
MOSC N-terminal domain-like0Direct
BEACH domain0Direct
CBD9-like0Direct
Kringle-like0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Subtilisin-like0Direct
PAP/OAS1 substrate-binding domain0Direct
Carboxypeptidase regulatory domain-like0Direct
R3H domain0Direct
S-adenosylmethionine synthetase0Direct
LDH C-terminal domain-like0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
DEATH domain0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
ADP-ribosylation0Direct
Thiolase-like0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
FAD-dependent thiol oxidase0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Acid phosphatase/Vanadium-dependent haloperoxidase0Direct
Nucleotidyltransferase0Direct
Ribosomal protein S180Direct
Bacterial exopeptidase dimerisation domain0Direct
LEM domain0Direct
Rudiment single hybrid motif0Direct
YbiA-like0Direct
Tubulin nucleotide-binding domain-like0Direct
Integrin domains0Direct
Elafin-like0Direct
Helical domain of Sec23/240Direct
HMG-box0Direct
CRAL/TRIO N-terminal domain0Direct
Lamin A/C globular tail domain0Direct
L-aspartase-like0Direct
Integrin alpha N-terminal domain0Direct
Cu,Zn superoxide dismutase-like0Direct
Diaminopimelate epimerase-like0Direct
Tim10-like0Direct
eIF4e-like0Direct
GAT-like domain0Direct
Tubby C-terminal domain-like0Direct
Phosphoenolpyruvate/pyruvate domain0Direct
Nucleoporin domain0Direct
PIN domain-like0Direct
HSP20-like chaperones0Direct
Zn-finger domain of Sec23/240Direct
Chromo domain-like0Direct
SMAD/FHA domain0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Cullin repeat-like0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
PEP carboxykinase-like0Direct
Intermediate filament protein, coiled coil region0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Translational machinery components0Direct
Heme-dependent peroxidases0Direct
LysM domain0Direct
Citrate synthase0Direct
TK C-terminal domain-like0Direct
MIR domain0Direct
Transducin (alpha subunit), insertion domain0Direct
Cullin homology domain0Direct
Phosphoglucomutase, first 3 domains0Direct
FF domain0Direct
HSP90 C-terminal domain0Direct
PEP carboxykinase N-terminal domain0Direct
L30e-like0Direct
Composite domain of metallo-dependent hydrolases0Direct
GYF domain0Direct
CO dehydrogenase ISP C-domain like0Direct
Acetyl-CoA synthetase-like0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
alpha-catenin/vinculin-like0Direct
ISP domain0Direct
PAP/Archaeal CCA-adding enzyme, C-terminal domain0Direct
Profilin (actin-binding protein)0Direct
Surp module (SWAP domain)0Direct
MFPT repeat-like0Direct
Calcium-dependent phosphotriesterase0Direct
Lipase/lipooxygenase domain (PLAT/LH2 domain)0Direct
Terpenoid synthases0Direct
Phosphoglucomutase, C-terminal domain0Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0Direct
Ribosomal protein L10-like0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
Ribosomal protein S100Direct
Annexin0Direct
Doublecortin (DC)0Direct
CAD & PB1 domains0Direct
PGBD-like0Direct
Sec1/munc18-like (SM) proteins0Direct
Hypothetical protein c14orf129, hspc2100Direct
Band 7/SPFH domain0Direct
Clc chloride channel0Direct
beta-lactamase/transpeptidase-like0Direct
Nop domain0Direct
Blood coagulation inhibitor (disintegrin)0Direct
SCP-like0Direct
SAICAR synthase-like0Direct
14-3-3 protein0Direct
SAND domain-like0Direct
Zn-binding ribosomal proteins0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
PurM C-terminal domain-like0Direct
ArfGap/RecO-like zinc finger0Direct
Cystatin/monellin0Direct
PUA domain-like0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
dsRNA-binding domain-like0Direct
Hormone receptor domain0Direct
ClpP/crotonase0Direct
FtsH protease domain-like0Direct
Formate/glycerate dehydrogenase catalytic domain-like0Direct
ARID-like0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Ferritin-like0Direct
Polo-box domain0Direct
Tubulin C-terminal domain-like0Direct
Fibrinogen C-terminal domain-like0Direct
Cation efflux protein cytoplasmic domain-like0Direct
Clathrin adaptor appendage domain0Direct
YWTD domain0Direct
PABC (PABP) domain0Direct
PreATP-grasp domain0Direct
HCP-like0Direct
Spectrin repeat0Direct
Sec7 domain0Direct
Sec63 N-terminal domain-like0Direct
Proton glutamate symport protein0Direct
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase0Direct
Type II DNA topoisomerase0Direct
Actin-like ATPase domain0Direct
PLP-binding barrel0Direct
WGR domain-like0Direct
lambda repressor-like DNA-binding domains0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Glycolipid transfer protein, GLTP0Direct
GroEL-intermediate domain like0Direct
Small-conductance potassium channel0Direct
Second domain of FERM0Direct
Hect, E3 ligase catalytic domain0Direct
ALDH-like0Direct
GAS2 domain-like0Direct
Cdc48 domain 2-like0Direct
AN1-like Zinc finger0Direct
cAMP-binding domain-like0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
Alpha-L RNA-binding motif0Direct
Ribosomal proteins S24e, L23 and L15e0Direct
Putative DNA-binding domain0Direct
3-carboxy-cis,cis-mucoante lactonizing enzyme0Direct
GroES-like0Direct
Class I glutamine amidotransferase-like0Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0Direct
HSP40/DnaJ peptide-binding domain0Direct
Arginase/deacetylase0Direct
ENTH/VHS domain0Direct
Creatinase/prolidase N-terminal domain0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Thyroglobulin type-1 domain0Direct
Succinyl-CoA synthetase domains0Direct
Cadherin-like0Direct
Smc hinge domain0Direct
Nucleoside diphosphate kinase, NDK0Direct
Oxysterol-binding protein-like0Direct
PHM/PNGase F0Direct
SIS domain0Direct
2Fe-2S ferredoxin-like0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
PurM N-terminal domain-like0Direct
Mitochondrial carrier0Direct
Chaperone J-domain0Direct
Chitinase insertion domain0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
F1F0 ATP synthase subunit C0Direct
PK beta-barrel domain-like0Direct
Periplasmic binding protein-like II0Direct
Single hybrid motif0Direct
ACP-like0Direct
Protease propeptides/inhibitors0Direct
Tricorn protease domain 20Direct
RBP11-like subunits of RNA polymerase0Direct
WWE domain0Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0Direct
Hedgehog/intein (Hint) domain0Direct
Ribosomal L27 protein-like0Direct
TGS-like0Direct
Ribokinase-like0Direct
Class II aaRS ABD-related0Direct
Ribosomal protein L10Direct
Outer arm dynein light chain 10Direct
Activating enzymes of the ubiquitin-like proteins0Direct
Cytochrome c0Direct
Heme-dependent catalase-like0Direct
GroEL apical domain-like0Direct
JAB1/MPN domain0Direct
P-loop containing nucleoside triphosphate hydrolases0.0000001345Direct
Histone-fold0.0001114Direct
PH domain-like0.0002937Direct
Protein kinase-like (PK-like)0.006915Inherited
PDZ domain-like0.01024Inherited
WD40 repeat-like0.01364Inherited
TPR-like0.01639Inherited
Nucleic acid-binding proteins0.01648Inherited
Periplasmic binding protein-like I0.01759Inherited
"Winged helix" DNA-binding domain0.02007Inherited
PapD-like0.02653Inherited
SH2 domain0.04147Inherited
Homeodomain-like0.06115Inherited
CCCH zinc finger0.07056Inherited
Cyclin-like0.07056Inherited
EGF/Laminin0.07474Inherited
ARM repeat0.09125Inherited
Translation proteins0.09692Inherited
Ankyrin repeat0.09726Inherited
Galactose-binding domain-like0.1008Inherited
HLH, helix-loop-helix DNA-binding domain0.1196Inherited
Nucleotide cyclase0.1196Inherited
ABC transporter transmembrane region0.1196Inherited
RNI-like0.124Inherited
Calcium ATPase, transmembrane domain M0.1324Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.1468Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.1468Inherited
Regulator of G-protein signaling, RGS0.1468Inherited
Acyl-CoA dehydrogenase NM domain-like0.1468Inherited
Calcium ATPase, transduction domain A0.1629Inherited
Class II aaRS and biotin synthetases0.1629Inherited
DBL homology domain (DH-domain)0.1805Inherited
Quinoprotein alcohol dehydrogenase-like0.1805Inherited
Multidrug efflux transporter AcrB transmembrane domain0.1962Inherited
Cytochrome P4500.2259Inherited
Multidrug resistance efflux transporter EmrE0.2459Inherited
BRCT domain0.2493Inherited
PLP-dependent transferases0.2507Inherited
Cysteine proteinases0.269Inherited
Bromodomain0.2712Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.2712Inherited
POZ domain0.2733Inherited
SAM/Pointed domain0.2851Inherited
Nucleotidylyl transferase0.2895Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.2905Inherited
SNARE-like0.2996Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.3058Inherited
SH3-domain0.3062Inherited
Lipocalins0.312Inherited
Ribosomal protein S5 domain 2-like0.3436Inherited
Nicotinic receptor ligand binding domain-like0.3483Inherited
Cation efflux protein transmembrane domain-like0.3648Inherited
Translation proteins SH3-like domain0.3648Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3729Inherited
Acid proteases0.3876Inherited
E set domains0.3909Inherited
Tropomyosin0.4031Inherited
FYVE/PHD zinc finger0.4097Inherited
Cysteine-rich domain0.4111Inherited
Ubiquitin-like0.4229Inherited
RNA-binding domain, RBD0.423Inherited
HAD-like0.427Inherited
DHS-like NAD/FAD-binding domain0.4884Inherited
Myosin rod fragments0.4884Inherited
PRTase-like0.4884Inherited
Voltage-gated potassium channels0.5067Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.5356Inherited
Riboflavin synthase domain-like0.5356Inherited
FAD-linked reductases, C-terminal domain0.5401Inherited
WW domain0.5401Inherited
Cystine-knot cytokines0.5401Inherited
Sm-like ribonucleoproteins0.5401Inherited
FAD/NAD(P)-binding domain0.5712Inherited
SET domain0.582Inherited
Seven-hairpin glycosidases0.5879Inherited
MFS general substrate transporter0.5938Inherited
Rhodanese/Cell cycle control phosphatase0.6092Inherited
Clavaminate synthase-like0.6213Inherited
Lipovitellin-phosvitin complex, superhelical domain0.6453Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.6453Inherited
Osmotin, thaumatin-like protein0.6453Inherited
Nucleotide-binding domain0.6453Inherited
KA1-like0.6453Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.6984Inherited
S15/NS1 RNA-binding domain0.7095Inherited
GST C-terminal domain-like0.7312Inherited
Ribonuclease H-like0.7314Inherited
alpha/beta-Hydrolases0.746Inherited
PAZ domain0.7585Inherited
ADC-like0.7781Inherited
MIT domain0.7781Inherited
UBC-like0.8162Inherited
Fibronectin type III0.8231Inherited
EF-hand0.8757Inherited
Leucine zipper domain0.8809Inherited
UBA-like0.881Inherited
CoA-dependent acyltransferases0.9191Inherited
p53-like transcription factors0.9501Inherited
Ribonuclease PH domain 2-like0.9602Inherited
DNase I-like0.9692Inherited
Immunoglobulin0.9737Inherited
Nuclear receptor ligand-binding domain0.9796Inherited
beta-beta-alpha zinc fingers0.98Inherited
Insulin-like1Inherited
B-box zinc-binding domain1Inherited
Saposin1Inherited
F-box domain1Inherited
Eukaryotic type KH-domain (KH-domain type I)1Inherited
RING/U-box1Inherited
Bet v1-like1Inherited
Ligand-binding domain in the NO signalling and Golgi transport1Inherited
Family A G protein-coupled receptor-like1Inherited
Thioredoxin-like1Inherited
FKBP-like1Inherited
Cyclophilin-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    56672,100879
  • 56672 - DNA/RNA polymerases
  • 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    53474,53474
  • 53474 - alpha/beta-Hydrolases
  • 53474 - alpha/beta-Hydrolases
  • 0Direct
    49742,49742
  • 49742 - PHM/PNGase F
  • 49742 - PHM/PNGase F
  • 0Direct
    56112,48371
  • 56112 - Protein kinase-like (PK-like)
  • 48371 - ARM repeat
  • 0Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    48403,52151
  • 48403 - Ankyrin repeat
  • 52151 - FabD/lysophospholipase-like
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53738,53738
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 0Direct
    52540,46785
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    101690,53098
  • 101690 - PAZ domain
  • 53098 - Ribonuclease H-like
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    52047,48371
  • 52047 - RNI-like
  • 48371 - ARM repeat
  • 0Direct
    52283,51735
  • 52283 - Formate/glycerate dehydrogenase catalytic domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    55729,55729
  • 55729 - Acyl-CoA N-acyltransferases (Nat)
  • 55729 - Acyl-CoA N-acyltransferases (Nat)
  • 0Direct
    57756,50630
  • 57756 - Retrovirus zinc finger-like domains
  • 50630 - Acid proteases
  • 0Direct
    57362,57362
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 0Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0Direct
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0Direct
    46785,46785
  • 46785 - "Winged helix" DNA-binding domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    47741,56176
  • 47741 - CO dehydrogenase ISP C-domain like
  • 56176 - FAD-binding/transporter-associated domain-like
  • 0Direct
    82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    51735,50129
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 0Direct
    53187,49464
  • 53187 - Zn-dependent exopeptidases
  • 49464 - Carboxypeptidase regulatory domain-like
  • 0Direct
    48464,89009
  • 48464 - ENTH/VHS domain
  • 89009 - GAT-like domain
  • 0Direct
    161093,161093
  • 161093 - MgtE membrane domain-like
  • 161093 - MgtE membrane domain-like
  • 0Direct
    55394,55394
  • 55394 - Bactericidal permeability-increasing protein, BPI
  • 55394 - Bactericidal permeability-increasing protein, BPI
  • 0Direct
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0Direct
    46938,52087
  • 46938 - CRAL/TRIO N-terminal domain
  • 52087 - CRAL/TRIO domain
  • 0Direct
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0Direct
    55326,56042
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 0Direct
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    51905,56425
  • 51905 - FAD/NAD(P)-binding domain
  • 56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
  • 0Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0Direct
    161111,160240
  • 161111 - Cation efflux protein transmembrane domain-like
  • 160240 - Cation efflux protein cytoplasmic domain-like
  • 0Direct
    51735,55347
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 0Direct
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    54236,54236
  • 54236 - Ubiquitin-like
  • 54236 - Ubiquitin-like
  • 0Direct
    47203,47203
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    54665,56003
  • 54665 - CO dehydrogenase molybdoprotein N-domain-like
  • 56003 - Molybdenum cofactor-binding domain
  • 0Direct
    144232,82199
  • 144232 - HIT/MYND zinc finger-like
  • 82199 - SET domain
  • 0Direct
    51445,51445
  • 51445 - (Trans)glycosidases
  • 51445 - (Trans)glycosidases
  • 0Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    103473,103473
  • 103473 - MFS general substrate transporter
  • 103473 - MFS general substrate transporter
  • 0Direct
    52047,52047
  • 52047 - RNI-like
  • 52047 - RNI-like
  • 0Direct
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0Direct
    52540,81271
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 81271 - TGS-like
  • 0Direct
    50044,52540
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0Direct
    57414,57414
  • 57414 - Hairpin loop containing domain-like
  • 57414 - Hairpin loop containing domain-like
  • 0Direct
    56601,48403
  • 56601 - beta-lactamase/transpeptidase-like
  • 48403 - Ankyrin repeat
  • 0Direct
    49348,55711
  • 49348 - Clathrin adaptor appendage domain
  • 55711 - Subdomain of clathrin and coatomer appendage domain
  • 0Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    52518,52922
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 0Direct
    57850,117839
  • 57850 - RING/U-box
  • 117839 - WWE domain
  • 0Direct
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    51338,51556
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 0Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    68923,53795
  • 68923 - PEP carboxykinase N-terminal domain
  • 53795 - PEP carboxykinase-like
  • 0Direct
    54211,55060
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55060 - GHMP Kinase, C-terminal domain
  • 0Direct
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0Direct
    51445,54556
  • 51445 - (Trans)glycosidases
  • 54556 - Chitinase insertion domain
  • 0Direct
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0Direct
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    47769,47769
  • 47769 - SAM/Pointed domain
  • 47769 - SAM/Pointed domain
  • 0Direct
    57863,48403
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0Direct
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    52518,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    47473,103506
  • 47473 - EF-hand
  • 103506 - Mitochondrial carrier
  • 0Direct
    57889,48350
  • 57889 - Cysteine-rich domain
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0Direct
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50978,50998
  • 50978 - WD40 repeat-like
  • 50998 - Quinoprotein alcohol dehydrogenase-like
  • 0Direct
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0Direct
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    54897,52743
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 0Direct
    48179,48179
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    48425,50729
  • 48425 - Sec7 domain
  • 50729 - PH domain-like
  • 0Direct
    51556,51338
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0Direct
    51971,54373
  • 51971 - Nucleotide-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 0Direct
    54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    50156,50044
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 0Direct
    57903,82199
  • 57903 - FYVE/PHD zinc finger
  • 82199 - SET domain
  • 0Direct
    52743,49785
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    81324,81327
  • 81324 - Voltage-gated potassium channels
  • 81327 - Small-conductance potassium channel
  • 0Direct
    81383,52047
  • 81383 - F-box domain
  • 52047 - RNI-like
  • 0Direct
    57756,57756
  • 57756 - Retrovirus zinc finger-like domains
  • 57756 - Retrovirus zinc finger-like domains
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0Direct
    53738,55957
  • 53738 - Phosphoglucomutase, first 3 domains
  • 55957 - Phosphoglucomutase, C-terminal domain
  • 0Direct
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0Direct
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0Direct
    56059,52210
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52210 - Succinyl-CoA synthetase domains
  • 0Direct
    81383,50978
  • 81383 - F-box domain
  • 50978 - WD40 repeat-like
  • 0Direct
    47576,47576
  • 47576 - Calponin-homology domain, CH-domain
  • 47576 - Calponin-homology domain, CH-domain
  • 0Direct
    54897,53187
  • 54897 - Protease propeptides/inhibitors
  • 53187 - Zn-dependent exopeptidases
  • 0Direct
    55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0Direct
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0Direct
    82615,82615
  • 82615 - Polo-box domain
  • 82615 - Polo-box domain
  • 0Direct
    74650,51445
  • 74650 - Galactose mutarotase-like
  • 51445 - (Trans)glycosidases
  • 0Direct
    52540,140990
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 140990 - FtsH protease domain-like
  • 0Direct
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0Direct
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0Direct
    81301,81631
  • 81301 - Nucleotidyltransferase
  • 81631 - PAP/OAS1 substrate-binding domain
  • 0Direct
    47587,56399
  • 47587 - Domain of poly(ADP-ribose) polymerase
  • 56399 - ADP-ribosylation
  • 0Direct
    47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0Direct
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0Direct
    50129,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0Direct
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    64356,49447
  • 64356 - SNARE-like
  • 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    51735,56327
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 56327 - LDH C-terminal domain-like
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    81698,81698
  • 81698 - FF domain
  • 81698 - FF domain
  • 0Direct
    81631,55003
  • 81631 - PAP/OAS1 substrate-binding domain
  • 55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain
  • 0Direct
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54292,47741
  • 54292 - 2Fe-2S ferredoxin-like
  • 47741 - CO dehydrogenase ISP C-domain like
  • 0Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0Direct
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0Direct
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    56112,82615
  • 56112 - Protein kinase-like (PK-like)
  • 82615 - Polo-box domain
  • 0Direct
    53187,55031
  • 53187 - Zn-dependent exopeptidases
  • 55031 - Bacterial exopeptidase dimerisation domain
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    55920,46785
  • 55920 - Creatinase/aminopeptidase
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53901,53901
  • 53901 - Thiolase-like
  • 53901 - Thiolase-like
  • 0Direct
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    57938,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    141739,141739
  • 141739 - MFPT repeat-like
  • 141739 - MFPT repeat-like
  • 0Direct
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0Direct
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0Direct
    57889,50729
  • 57889 - Cysteine-rich domain
  • 50729 - PH domain-like
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0Direct
    141673,50800
  • 141673 - MOSC N-terminal domain-like
  • 50800 - PK beta-barrel domain-like
  • 0Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.01581Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.1194Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1196Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.1468Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.1468Inherited
    56112,55073
  • 56112 - Protein kinase-like (PK-like)
  • 55073 - Nucleotide cyclase
  • 0.1468Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.1796Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.2219Inherited
    56436,49854
  • 56436 - C-type lectin-like
  • 49854 - Spermadhesin, CUB domain
  • 0.2686Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.2712Inherited
    51735,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0.2712Inherited
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0.2996Inherited
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.3307Inherited
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.3307Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.3307Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.3648Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.3729Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.3876Inherited
    48403,48403
  • 48403 - Ankyrin repeat
  • 48403 - Ankyrin repeat
  • 0.4884Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.4928Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.5103Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 0.5569Inherited
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.5879Inherited
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.6453Inherited
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0.6453Inherited
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0.6453Inherited
    51905,54373
  • 51905 - FAD/NAD(P)-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 0.6867Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.7095Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.8627Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9118Inherited
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0.9602Inherited
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.9692Inherited
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 1Inherited
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 1Inherited
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    54928,54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    50249,50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    57362,57362,57362
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 0Direct
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0Direct
    53738,53738,55957
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 55957 - Phosphoglucomutase, C-terminal domain
  • 0Direct
    56436,49854,49854
  • 56436 - C-type lectin-like
  • 49854 - Spermadhesin, CUB domain
  • 49854 - Spermadhesin, CUB domain
  • 0Direct
    46938,52087,101576
  • 46938 - CRAL/TRIO N-terminal domain
  • 52087 - CRAL/TRIO domain
  • 101576 - Supernatant protein factor (SPF), C-terminal domain
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    51735,48179,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    55973,55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0Direct
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    56112,82615,82615
  • 56112 - Protein kinase-like (PK-like)
  • 82615 - Polo-box domain
  • 82615 - Polo-box domain
  • 0Direct
    57938,49493,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    48452,48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0Direct
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    53738,53738,53738
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 0Direct
    81301,81631,55003
  • 81301 - Nucleotidyltransferase
  • 81631 - PAP/OAS1 substrate-binding domain
  • 55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain
  • 0Direct
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0Direct
    57567,57567,57567
  • 57567 - Serine protease inhibitors
  • 57567 - Serine protease inhibitors
  • 57567 - Serine protease inhibitors
  • 0Direct
    54897,52743,49785
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0Direct
    49785,49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0Direct
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0Direct
    48371,48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    48726,49265,48726
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    50129,51735,50129
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 0Direct
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    56645,47203,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    50156,50044,52540
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50044,50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0Direct
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    82895,82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    54292,47741,56176
  • 54292 - 2Fe-2S ferredoxin-like
  • 47741 - CO dehydrogenase ISP C-domain like
  • 56176 - FAD-binding/transporter-associated domain-like
  • 0Direct
    57414,57414,57414
  • 57414 - Hairpin loop containing domain-like
  • 57414 - Hairpin loop containing domain-like
  • 57414 - Hairpin loop containing domain-like
  • 0Direct
    74650,51445,51011
  • 74650 - Galactose mutarotase-like
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0Direct
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    63411,63411,63411
  • 63411 - LuxS/MPP-like metallohydrolase
  • 63411 - LuxS/MPP-like metallohydrolase
  • 63411 - LuxS/MPP-like metallohydrolase
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.1629Inherited
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.4031Inherited
    56436,56436,49854
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 49854 - Spermadhesin, CUB domain
  • 0.4162Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.4884Inherited
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.6453Inherited
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.8862Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9949Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 1Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 1Inherited


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