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Worm Phenotype (WP): organism physiology variant

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Variant [WBPhenotype:0000886] <2>
+ 1:   physiology variant [WBPhenotype:0000519] <15>(509|582) (509|247|68)
0:   organism physiology variant [WBPhenotype:0000576] <11>(366|425) (369|192|56)
- 1:   organism homeostasis metabolism variant [WBPhenotype:0000577] <16>(358|416) (360|189|55)
- 1:   dauer arrest variant [WBPhenotype:0000159] <6>(9|11) (9|5|0)
- 1:   dauer development variant [WBPhenotype:0000308] <6>(9|10) (9|5|0)
- 1:   life span variant [WBPhenotype:0000039] <6>(27|30) (28|14|3)
- 1:   aging variant [WBPhenotype:0001739] <4>(1|0) (1|0|0)
- 1:   genetic pathway variant [WBPhenotype:0000074] <2>(0|0) (0|0|0)
- 1:   sexually dimorphic physiology variant [WBPhenotype:0000889] <2>(25|22) (26|11|2)
- 1:   heteroplasmy [WBPhenotype:0002121] <1>(2|1) (2|1|0)
- 1:   growth defective on low phosphate media [WBPhenotype:0002235](0|0) (0|0|0)
- 1:   larval physiology variant [WBPhenotype:0001293](0|0) (0|0|0)
- 1:   subviable [WBPhenotype:0002116](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
SCP-like0Direct
CAD & PB1 domains0Direct
FtsH protease domain-like0Direct
Tubby C-terminal domain-like0Direct
TK C-terminal domain-like0Direct
Ribosomal protein L10Direct
RBP11-like subunits of RNA polymerase0Direct
Ribosomal proteins S24e, L23 and L15e0Direct
Heme-dependent catalase-like0Direct
Ferritin-like0Direct
Cullin repeat-like0Direct
LysM domain0Direct
Retrovirus zinc finger-like domains0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
Cystatin/monellin0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
CBD9-like0Direct
Galactose mutarotase-like0Direct
alpha-catenin/vinculin-like0Direct
AN1-like Zinc finger0Direct
MIR domain0Direct
Ribosomal protein S180Direct
Formate/glycerate dehydrogenase catalytic domain-like0Direct
PUA domain-like0Direct
Zn-finger domain of Sec23/240Direct
Thiolase-like0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
HRDC-like0Direct
Carbohydrate phosphatase0Direct
PLC-like phosphodiesterases0Direct
Integrin domains0Direct
Aquaporin-like0Direct
ADP-ribosylation0Direct
GroEL equatorial domain-like0Direct
SAND domain-like0Direct
t-snare proteins0Direct
ArfGap/RecO-like zinc finger0Direct
R3H domain0Direct
Nucleotidyltransferase0Direct
ACP-like0Direct
Carbon-nitrogen hydrolase0Direct
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase0Direct
Nucleoside diphosphate kinase, NDK0Direct
Chromo domain-like0Direct
PGBD-like0Direct
Transducin (alpha subunit), insertion domain0Direct
ALDH-like0Direct
Proton glutamate symport protein0Direct
Ribosomal L27 protein-like0Direct
Cation efflux protein cytoplasmic domain-like0Direct
beta-lactamase/transpeptidase-like0Direct
Mitochondrial carrier0Direct
ISP domain0Direct
Aldolase0Direct
SIS domain0Direct
3-carboxy-cis,cis-mucoante lactonizing enzyme0Direct
PurM N-terminal domain-like0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
Galactose oxidase, central domain0Direct
Class I glutamine amidotransferase-like0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
MgtE membrane domain-like0Direct
Profilin (actin-binding protein)0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
ENTH/VHS domain0Direct
Families 57/38 glycoside transferase middle domain0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0Direct
Activating enzymes of the ubiquitin-like proteins0Direct
Acyl-CoA dehydrogenase C-terminal domain-like0Direct
Succinyl-CoA synthetase domains0Direct
HSP90 C-terminal domain0Direct
WGR domain-like0Direct
cAMP-binding domain-like0Direct
CRAL/TRIO N-terminal domain0Direct
Kringle-like0Direct
Acetyl-CoA synthetase-like0Direct
Doublecortin (DC)0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
eIF4e-like0Direct
Citrate synthase0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Terpenoid synthases0Direct
DNA repair protein MutS, domain III0Direct
Oxysterol-binding protein-like0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
F1F0 ATP synthase subunit C0Direct
LEM domain0Direct
PHM/PNGase F0Direct
Actin-like ATPase domain0Direct
PreATP-grasp domain0Direct
dsRNA-binding domain-like0Direct
PLP-binding barrel0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
PK beta-barrel domain-like0Direct
Phoshotransferase/anion transport protein0Direct
VPS9 domain0Direct
Creatinase/prolidase N-terminal domain0Direct
Arginase/deacetylase0Direct
Surp module (SWAP domain)0Direct
Complement control module/SCR domain0Direct
SWIB/MDM2 domain0Direct
Spectrin repeat0Direct
Insulin-like0Direct
L30e-like0Direct
SPOC domain-like0Direct
Phosphoglucomutase, first 3 domains0Direct
Tim10-like0Direct
Skp1 dimerisation domain-like0Direct
FAD-linked oxidases, C-terminal domain0Direct
Rap/Ran-GAP0Direct
PIN domain-like0Direct
BEACH domain0Direct
DEATH domain0Direct
YWTD domain0Direct
S-adenosylmethionine synthetase0Direct
YbiA-like0Direct
Single hybrid motif0Direct
Lipovitellin-phosvitin complex, superhelical domain0Direct
Nucleoporin domain0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
MFPT repeat-like0Direct
GAS2 domain-like0Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0Direct
Terpenoid cyclases/Protein prenyltransferases0Direct
SMAD MH1 domain0Direct
PEP carboxykinase N-terminal domain0Direct
Tricorn protease domain 20Direct
Hormone receptor domain0Direct
GroEL-intermediate domain like0Direct
Sec1/munc18-like (SM) proteins0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Carbonic anhydrase0Direct
Band 7/SPFH domain0Direct
ARID-like0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
GAT-like domain0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Transducin (heterotrimeric G protein), gamma chain0Direct
alpha/beta knot0Direct
Sec63 N-terminal domain-like0Direct
Sec7 domain0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Phosphoenolpyruvate/pyruvate domain0Direct
14-3-3 protein0Direct
Nop domain0Direct
Tubulin nucleotide-binding domain-like0Direct
LDH C-terminal domain-like0Direct
Carboxypeptidase regulatory domain-like0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Cytochrome c0Direct
Blood coagulation inhibitor (disintegrin)0Direct
PAP/OAS1 substrate-binding domain0Direct
Helical domain of Sec23/240Direct
Subtilisin-like0Direct
GroES-like0Direct
Pepsin inhibitor-30Direct
Small-conductance potassium channel0Direct
HSP20-like chaperones0Direct
Hypothetical protein c14orf129, hspc2100Direct
Integrin alpha N-terminal domain0Direct
lambda repressor-like DNA-binding domains0Direct
2Fe-2S ferredoxin-like0Direct
HSP40/DnaJ peptide-binding domain0Direct
Cdc48 domain 2-like0Direct
Thyroglobulin type-1 domain0Direct
Phosphoglucomutase, C-terminal domain0Direct
PABC (PABP) domain0Direct
Heme-dependent peroxidases0Direct
SAICAR synthase-like0Direct
Restriction endonuclease-like0Direct
Chitinase insertion domain0Direct
Clathrin adaptor appendage domain0Direct
Ran binding protein zinc finger-like0Direct
Cu,Zn superoxide dismutase-like0Direct
Radical SAM enzymes0Direct
Ribosomal protein L10-like0Direct
Glycolipid transfer protein, GLTP0Direct
Clc chloride channel0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
Tubulin C-terminal domain-like0Direct
Smc hinge domain0Direct
PYP-like sensor domain (PAS domain)0Direct
Bacterial exopeptidase dimerisation domain0Direct
Periplasmic binding protein-like II0Direct
Chaperone J-domain0Direct
Ribulose-phoshate binding barrel0Direct
Annexin0Direct
HCP-like0Direct
Class II aaRS ABD-related0Direct
PEBP-like0Direct
Putative DNA-binding domain0Direct
WWE domain0Direct
JAB1/MPN domain0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
Pentein0Direct
FAD-dependent thiol oxidase0Direct
FAD-binding/transporter-associated domain-like0Direct
Hedgehog/intein (Hint) domain0Direct
Lamin A/C globular tail domain0Direct
PurM C-terminal domain-like0Direct
Ribosomal protein S100Direct
Acyl-CoA dehydrogenase NM domain-like0Direct
Intermediate filament protein, coiled coil region0Direct
Molybdenum cofactor-binding domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
GroEL apical domain-like0Direct
Domain of poly(ADP-ribose) polymerase0Direct
Second domain of FERM0Direct
Fibrinogen C-terminal domain-like0Direct
Glutathione synthetase ATP-binding domain-like0Direct
GYF domain0Direct
Composite domain of metallo-dependent hydrolases0Direct
Zn-binding ribosomal proteins0Direct
Histone-fold0Direct
Acid phosphatase/Vanadium-dependent haloperoxidase0Direct
PEP carboxykinase-like0Direct
TGS-like0Direct
Diaminopimelate epimerase-like0Direct
Troponin coil-coiled subunits0Direct
MOSC N-terminal domain-like0Direct
FF domain0Direct
Ribokinase-like0Direct
Polo-box domain0Direct
ThrRS/AlaRS common domain0Direct
Protease propeptides/inhibitors0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
CO dehydrogenase ISP C-domain like0Direct
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)0Direct
Translational machinery components0Direct
Invertebrate chitin-binding proteins0Direct
Rudiment single hybrid motif0Direct
L-aspartase-like0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Outer arm dynein light chain 10Direct
ValRS/IleRS/LeuRS editing domain0Direct
Cullin homology domain0Direct
Elafin-like0Direct
Cadherin-like0Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
NagB/RpiA/CoA transferase-like0Direct
P-loop containing nucleoside triphosphate hydrolases0.00000007798Direct
PH domain-like0.00001907Direct
PDZ domain-like0.008703Inherited
TPR-like0.01221Inherited
Periplasmic binding protein-like I0.01392Inherited
ARM repeat0.01805Inherited
ABC transporter transmembrane region0.01964Inherited
PapD-like0.02301Inherited
Protein kinase-like (PK-like)0.04522Inherited
Nucleic acid-binding proteins0.04629Inherited
Homeodomain-like0.05168Inherited
WD40 repeat-like0.06117Inherited
CCCH zinc finger0.06793Inherited
FYVE/PHD zinc finger0.07678Inherited
Translation proteins0.08478Inherited
"Winged helix" DNA-binding domain0.0937Inherited
Ankyrin repeat0.09895Inherited
HLH, helix-loop-helix DNA-binding domain0.09914Inherited
Nucleotide cyclase0.09914Inherited
SMAD/FHA domain0.1059Inherited
BRCT domain0.1059Inherited
Calcium ATPase, transmembrane domain M0.1182Inherited
SH3-domain0.123Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.132Inherited
Regulator of G-protein signaling, RGS0.132Inherited
EGF/Laminin0.1351Inherited
Calcium ATPase, transduction domain A0.147Inherited
Acid proteases0.147Inherited
Cysteine-rich domain0.1548Inherited
Quinoprotein alcohol dehydrogenase-like0.1639Inherited
Multidrug efflux transporter AcrB transmembrane domain0.1689Inherited
Cytochrome P4500.1818Inherited
ClpP/crotonase0.1826Inherited
DBL homology domain (DH-domain)0.1826Inherited
HMG-box0.1826Inherited
E set domains0.186Inherited
(Trans)glycosidases0.1925Inherited
Cyclin-like0.2365Inherited
Cysteine proteinases0.2428Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.2511Inherited
Bromodomain0.2511Inherited
Tudor/PWWP/MBT0.2511Inherited
POZ domain0.2601Inherited
RNA-binding domain, RBD0.2709Inherited
Lipocalins0.2779Inherited
SNARE-like0.2789Inherited
Metallo-dependent phosphatases0.2804Inherited
Cation efflux protein transmembrane domain-like0.343Inherited
Translation proteins SH3-like domain0.343Inherited
PX domain0.343Inherited
HAD-like0.3625Inherited
Nicotinic receptor ligand binding domain-like0.375Inherited
Ubiquitin-like0.3922Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.4114Inherited
RNI-like0.4179Inherited
FKBP-like0.4192Inherited
HD-domain/PDEase-like0.4192Inherited
Class II aaRS and biotin synthetases0.4353Inherited
DHS-like NAD/FAD-binding domain0.4642Inherited
Myosin rod fragments0.4642Inherited
PRTase-like0.4642Inherited
Hect, E3 ligase catalytic domain0.4642Inherited
Ribosomal protein S5 domain 2-like0.4963Inherited
Galactose-binding domain-like0.4963Inherited
Cystine-knot cytokines0.5003Inherited
WW domain0.5003Inherited
Sm-like ribonucleoproteins0.5003Inherited
SH2 domain0.5041Inherited
Calpain large subunit, middle domain (domain III)0.5108Inherited
Riboflavin synthase domain-like0.5108Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.5108Inherited
FAD/NAD(P)-binding domain0.5223Inherited
FAD-linked reductases, C-terminal domain0.5355Inherited
Voltage-gated potassium channels0.5365Inherited
SAM/Pointed domain0.5432Inherited
Nucleotidylyl transferase0.5432Inherited
UBC-like0.5454Inherited
SET domain0.5454Inherited
Seven-hairpin glycosidases0.5661Inherited
Multidrug resistance efflux transporter EmrE0.5717Inherited
PLP-dependent transferases0.5893Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.6053Inherited
Di-copper centre-containing domain0.6214Inherited
Nucleotide-binding domain0.6214Inherited
KA1-like0.6214Inherited
HIT/MYND zinc finger-like0.6475Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.6484Inherited
MFS general substrate transporter0.6858Inherited
4Fe-4S ferredoxins0.686Inherited
S15/NS1 RNA-binding domain0.686Inherited
Frizzled cysteine-rich domain0.686Inherited
GST C-terminal domain-like0.6916Inherited
alpha/beta-Hydrolases0.7487Inherited
EF-hand0.7546Inherited
ADC-like0.7553Inherited
MIT domain0.7553Inherited
Clavaminate synthase-like0.8079Inherited
NAD kinase/diacylglycerol kinase-like0.813Inherited
Cyclophilin-like0.8208Inherited
CoA-dependent acyltransferases0.8208Inherited
UBA-like0.8318Inherited
SNF-like0.8516Inherited
Leucine zipper domain0.857Inherited
GTPase activation domain, GAP0.8655Inherited
Thioredoxin-like0.895Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.9043Inherited
p53-like transcription factors0.9044Inherited
Immunoglobulin0.9093Inherited
Ribonuclease PH domain 2-like0.9313Inherited
DNA/RNA polymerases0.9349Inherited
Saposin0.9568Inherited
Ribonuclease H-like0.9727Inherited
PAZ domain0.99Inherited
RING/U-box1Inherited
Nuclear receptor ligand-binding domain1Inherited
Bet v1-like1Inherited
B-box zinc-binding domain1Inherited
F-box domain1Inherited
Snake toxin-like1Inherited
Ligand-binding domain in the NO signalling and Golgi transport1Inherited
Family A G protein-coupled receptor-like1Inherited
beta-beta-alpha zinc fingers1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Ribosomal protein S100Direct
Transducin (heterotrimeric G protein), gamma chain0Direct
RNA-polymerase beta-prime0Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
Sec7 domain0Direct
Carbonic anhydrase0Direct
XPF/Rad1/Mus81 nuclease0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Armadillo repeat0Direct
Clc chloride channel0Direct
Troponin I0Direct
Phosphoglucomutase, first 3 domains0Direct
MutT-like0Direct
Matrix metalloproteases, catalytic domain0Direct
COMT-like0Direct
Thiolase-related0Direct
Type II chitinase0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Sir2 family of transcriptional regulators0Direct
POU-specific domain0Direct
Glycosyl transferases group 10Direct
alpha-mannosidase0Direct
YihX-like0Direct
Domain of poly(ADP-ribose) polymerase0Direct
NTF2-like0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Protein prenyltransferases0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Paired domain0Direct
VHS domain0Direct
GYF domain0Direct
AMPK-beta glycogen binding domain-like0Direct
U-box0Direct
D-aminoacid oxidase-like0Direct
ALDH-like0Direct
Proprotein convertase P-domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
ValRS/IleRS/LeuRS editing domain0Direct
Hydantoinase (dihydropyrimidinase), catalytic domain0Direct
beta-Lactamase/D-ala carboxypeptidase0Direct
Pumilio repeat0Direct
alpha-catenin/vinculin0Direct
Band 7/SPFH domain0Direct
Hexokinase0Direct
Oxysterol-binding protein0Direct
DPP6 catalytic domain-like0Direct
5' to 3' exonuclease catalytic domain0Direct
Cofilin-like0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Acetyl-CoA synthetase-like0Direct
Hypothetical protein c14orf129, hspc2100Direct
CO dehydrogenase flavoprotein N-terminal domain-like0Direct
Gamma-glutamyltranspeptidase-like0Direct
LysM domain0Direct
FYVE, a phosphatidylinositol-3-phosphate binding domain0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
Chitinase insertion domain0Direct
Ran binding protein zinc finger-like0Direct
Brix domain0Direct
Mitochondrial carrier0Direct
NHL repeat0Direct
Proteasome subunits0Direct
Group II chaperonin (CCT, TRIC), ATPase domain0Direct
Group II chaperonin (CCT, TRIC), apical domain0Direct
Inositol monophosphatase/fructose-1,6-bisphosphatase-like0Direct
Ribosomal protein L18 and S110Direct
Dual specificity phosphatase-like0Direct
SAM (sterile alpha motif) domain0Direct
Thyroglobulin type-1 domain0Direct
HSP40/DnaJ peptide-binding domain0Direct
Ribokinase-like0Direct
Poly(ADP-ribose) polymerase, C-terminal domain0Direct
Nucleosome core histones0Direct
Actin/HSP700Direct
HSP90 C-terminal domain0Direct
Intermediate filament protein, coiled coil region0Direct
Clathrin coat assembly domain0Direct
SMAD MH1 domain0Direct
Hsp90 middle domain0Direct
GAS2 domain0Direct
Lactate & malate dehydrogenases, C-terminal domain0Direct
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)0Direct
Spectrin repeat0Direct
PurM C-terminal domain-like0Direct
RecA protein-like (ATPase-domain)0Direct
Second domain of FERM0Direct
CoA-binding domain0Direct
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta0Direct
NOL1/NOP2/sun0Direct
PEP carboxykinase N-terminal domain0Direct
IF2B-like0Direct
Cytoplasmic domain of inward rectifier potassium channel0Direct
Profilin (actin-binding protein)0Direct
LEM domain0Direct
Choline kinase0Direct
DEP domain0Direct
Double-stranded RNA-binding domain (dsRBD)0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain0Direct
Citrate synthase0Direct
Pancreatic carboxypeptidases0Direct
Phosphatidylethanolamine binding protein0Direct
BAR domain0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
Histone deacetylase, HDAC0Direct
RhoGDI-like0Direct
CoA transferase alpha subunit-like0Direct
Phosphoribosyltransferases (PRTases)0Direct
Reductases0Direct
Retrovirus zinc finger-like domains0Direct
beta 1,4 galactosyltransferase (b4GalT1)0Direct
Insulin-like0Direct
Hedgehog C-terminal (Hog) autoprocessing domain0Direct
beta-sandwich domain of Sec23/240Direct
Clathrin adaptor core protein0Direct
Vertebrate phospholipase A20Direct
TBP-associated factors, TAFs0Direct
Alcohol dehydrogenase-like, N-terminal domain0Direct
CUT domain0Direct
Sec63 N-terminal domain0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
NLI interacting factor-like phosphatase0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
SWIRM domain0Direct
Translation initiation factor eIF4e0Direct
Tetraspanin0Direct
Calpain large subunit, catalytic domain (domain II)0Direct
PUA domain0Direct
YicI catalytic domain-like0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0Direct
Doublecortin (DC)0Direct
DNA repair protein MutS, domain III0Direct
UBA domain0Direct
Aquaporin-like0Direct
Quinoprotein alcohol dehydrogenase-like0Direct
PLC-like (P variant)0Direct
Carboxypeptidase regulatory domain0Direct
Myotubularin-like phosphatases0Direct
acyl-CoA oxidase C-terminal domains0Direct
CRAL/TRIO N-terminal domain0Direct
Rap/Ran-GAP0Direct
Polo-box duplicated region0Direct
Integrin domains0Direct
PDI-like0Direct
RNA editing terminal uridyl transferase 2, RET2, domain 20Direct
HAT/Suf repeat0Direct
Regulator of chromosome condensation RCC10Direct
Surp module (SWAP domain)0Direct
Ribosomal protein S180Direct
Phosphate binding protein-like0Direct
Linker histone H1/H50Direct
PhzC/PhzF-like0Direct
Smc hinge domain0Direct
Fibrinogen C-terminal domain-like0Direct
Arylsulfatase0Direct
SAND domain0Direct
p120GAP domain-like0Direct
Nucleoside diphosphate kinase, NDK0Direct
HD domain0Direct
Reprolysin-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Phosphotyrosine-binding domain (PTB)0Direct
WGR domain0Direct
Pyk2-associated protein beta ARF-GAP domain0Direct
Calcium ATPase, transmembrane domain M0Direct
MIF4G domain-like0Direct
Glycogenin0Direct
Glycolipid transfer protein, GLTP0Direct
Pepsin inhibitor-30Direct
L30e/L7ae ribosomal proteins0Direct
Eps15 homology domain (EH domain)0Direct
Cdc48 domain 2-like0Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
CAT-like0Direct
Tubulin, GTPase domain0Direct
Hydantoinase (dihydropyrimidinase)0Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0Direct
Fatty acid binding protein-like0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain0Direct
FAD-dependent thiol oxidase0Direct
DEATH domain, DD0Direct
Annexin0Direct
Class I aldolase0Direct
Erythroid transcription factor GATA-10Direct
Cadherin0Direct
Lamin A/C globular tail domain0Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
Zn-finger domain of Sec23/240Direct
Sec63 C-terminal domain-like0Direct
Filamin repeat (rod domain)0Direct
Ribosomal protein L10Direct
D-aminoacid oxidase, N-terminal domain0Direct
Peptidylglycine alpha-hydroxylating monooxygenase, PHM0Direct
F1F0 ATP synthase subunit C0Direct
MOSC N-terminal domain-like0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
Class II glutamine amidotransferases0Direct
HEAT repeat0Direct
a tRNA synthase domain0Direct
DNA gyrase/MutL, N-terminal domain0Direct
Nop domain0Direct
Sec1/munc18-like (SM) proteins0Direct
PaaI/YdiI-like0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Tubulin, C-terminal domain0Direct
PABC (PABP) domain0Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
Bactericidal permeability-increasing protein, BPI0Direct
PDZ domain0Direct
alpha-mannosidase, domain 20Direct
Sterol carrier protein, SCP0Direct
Branched-chain alpha-keto acid dehydrogenase Pyr module0Direct
Elafin-like0Direct
Biotinyl/lipoyl-carrier proteins and domains0Direct
14-3-3 protein0Direct
AN1-like Zinc finger0Direct
Ngr ectodomain-like0Direct
Helical domain of Sec23/240Direct
Aminoacid dehydrogenase-like, C-terminal domain0Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
Succinyl-CoA synthetase domains0Direct
Internalin LRR domain0Direct
Ubiquitin activating enzymes (UBA)0Direct
Formate/glycerate dehydrogenases, NAD-domain0Direct
GAPDH-like0Direct
1,3-glucuronyltransferase0Direct
Chaperone J-domain0Direct
Class I glutamine amidotransferases (GAT)0Direct
SCF ubiquitin ligase complex WHB domain0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Molybdenum cofactor-binding domain0Direct
DNA gyrase/MutL, second domain0Direct
PDEase0Direct
ATP-dependent protease Lon (La), catalytic domain0Direct
Trunk domain of Sec23/240Direct
UDP-glucose pyrophosphorylase0Direct
Biotin dependent carboxylase carboxyltransferase domain0Direct
Regulator of G-protein signaling, RGS0Direct
Ras-binding domain, RBD0Direct
Acyl-CoA thioesterase0Direct
Myeloperoxidase-like0Direct
CO dehydrogenase ISP C-domain like0Direct
Acireductone dioxygenase0Direct
Alcohol dehydrogenase-like, C-terminal domain0Direct
LacY-like proton/sugar symporter0Direct
Lesion bypass DNA polymerase (Y-family), catalytic domain0Direct
Pancreatic carboxypeptidase, activation domain0Direct
Blood coagulation inhibitor (disintegrin)0Direct
HSP200Direct
alpha-mannosidase, C-terminal domain0Direct
RNA-polymerase beta0Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0Direct
Skp1 dimerisation domain-like0Direct
Pleckstrin-homology domain (PH domain)0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
S-adenosylmethionine synthetase0Direct
Branched-chain alpha-keto acid dehydrogenase PP module0Direct
Transducin (alpha subunit), insertion domain0Direct
HCDH C-domain-like0Direct
28-residue LRR0Direct
FtsH protease domain-like0Direct
SWIB/MDM2 domain0Direct
MFPT repeat0Direct
Subtilases0Direct
BC N-terminal domain-like0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
MIR domain0Direct
Small-conductance potassium channel0Direct
Cation efflux protein cytoplasmic domain-like0Direct
Arfaptin, Rac-binding fragment0Direct
Lipovitellin-phosvitin complex, superhelical domain0Direct
Third domain of FERM0Direct
BC C-terminal domain-like0Direct
YbiA-like0Direct
Glycerol kinase0Direct
PurM N-terminal domain-like0Direct
L-aminoacid/polyamine oxidase0Direct
BEACH domain0Direct
BC ATP-binding domain-like0Direct
DPP6 N-terminal domain-like0Direct
SMAD domain0Direct
Acylamino-acid-releasing enzyme, C-terminal donain0Direct
Glycerophosphoryl diester phosphodiesterase0Direct
WWE domain0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
Methionine aminopeptidase, insert domain0Direct
Anticodon-binding domain0Direct
Cullin homology domain0Direct
Tim10/DDP0Direct
Chromo domain0Direct
FF domain0Direct
t-snare proteins0Direct
Anticodon-binding domain of Class II aaRS0Direct
FHA domain0Direct
Acyl-carrier protein (ACP)0Direct
Arginine methyltransferase0Direct
Amylase, catalytic domain0Direct
PEP carboxykinase C-terminal domain0Direct
First domain of FERM0Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0Direct
Hormone receptor domain0Direct
ARID domain0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
La domain0Direct
Adenain-like0Direct
Cullin repeat0Direct
Heme-dependent catalases0Direct
Epoxide hydrolase0Direct
Laminin G-like module0Direct
2Fe-2S ferredoxin domains from multidomain proteins0Direct
LDH N-terminal domain-like0Direct
Inositol polyphosphate kinase (IPK)0Direct
YWTD domain0Direct
cAMP-binding domain0Direct
Cu,Zn superoxide dismutase-like0Direct
Complement control module/SCR domain0Direct
Cell cycle control phosphatase, catalytic domain0Direct
ets domain0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Glutaminase0Direct
Proton glutamate symport protein0Direct
Mammalian PLC0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain0Direct
Translational machinery components0Direct
Bacterial exopeptidase dimerisation domain0Direct
acyl-CoA oxidase N-terminal domains0Direct
Single strand DNA-binding domain, SSB0Direct
ABC transporter ATPase domain-like0.001183Inherited
Tandem AAA-ATPase domain0.003427Inherited
Homeodomain0.03517Inherited
ABC transporter transmembrane region0.04123Inherited
G proteins0.04445Inherited
WD40-repeat0.04457Inherited
L-arabinose binding protein-like0.05603Inherited
MSP-like0.06024Inherited
Protein kinases, catalytic subunit0.07544Inherited
CCCH zinc finger0.08395Inherited
Canonical RBD0.08683Inherited
Extended AAA-ATPase domain0.1016Inherited
Tetratricopeptide repeat (TPR)0.1103Inherited
Cold shock DNA-binding domain-like0.1254Inherited
Adenylyl and guanylyl cyclase catalytic domain0.1298Inherited
Motor proteins0.1298Inherited
HLH, helix-loop-helix DNA-binding domain0.1298Inherited
Ankyrin repeat0.1692Inherited
Calcium ATPase, transduction domain A0.1693Inherited
SH3-domain0.1764Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.2064Inherited
Elongation factors0.2064Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.2064Inherited
DBL homology domain (DH-domain)0.2064Inherited
Cyclin0.2064Inherited
HMG-box0.2064Inherited
Pepsin-like0.2277Inherited
Histone lysine methyltransferases0.2277Inherited
Forkhead DNA-binding domain0.2514Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.2514Inherited
Multidrug efflux transporter AcrB transmembrane domain0.261Inherited
Cytochrome P4500.265Inherited
Bromodomain0.2768Inherited
6-phosphogluconate dehydrogenase-like, N-terminal domain0.2768Inherited
Acetylcholinesterase-like0.2842Inherited
FAD/NAD-linked reductases, N-terminal and central domains0.3046Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3177Inherited
Meta-cation ATPase, catalytic domain P0.3352Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP0.3352Inherited
Crotonase-like0.3352Inherited
PX domain0.3696Inherited
GABA-aminotransferase-like0.4041Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.4254Inherited
BTB/POZ domain0.4256Inherited
FKBP immunophilin/proline isomerase0.4452Inherited
Cation efflux protein transmembrane domain-like0.4452Inherited
PHD domain0.4537Inherited
Pyridoxal-dependent decarboxylase0.4864Inherited
Hect, E3 ligase catalytic domain0.4864Inherited
Myosin rod fragments0.4864Inherited
Glutathione S-transferase (GST), N-terminal domain0.4896Inherited
Nicotinic receptor ligand binding domain-like0.5135Inherited
I set domains0.5143Inherited
Papain-like0.524Inherited
Calpain large subunit, middle domain (domain III)0.535Inherited
Gastric lipase0.535Inherited
Myb/SANT domain0.535Inherited
WW domain0.5452Inherited
UBC-related0.5747Inherited
Class I alpha-1;2-mannosidase, catalytic domain0.5833Inherited
Synaptotagmin-like (S variant)0.6135Inherited
SH2 domain0.615Inherited
Ubiquitin carboxyl-terminal hydrolase, UCH0.659Inherited
Frizzled cysteine-rich domain0.7002Inherited
Transforming growth factor (TGF)-beta0.7002Inherited
EF-hand modules in multidomain proteins0.7002Inherited
Ubiquitin-related0.7403Inherited
H-NOX domain0.7658Inherited
Cdc48 N-terminal domain-like0.7658Inherited
Hemocyanin middle domain0.7658Inherited
Bacterial lipase0.7658Inherited
MIT domain0.7658Inherited
Voltage-gated potassium channels0.7843Inherited
AAT-like0.8366Inherited
LIM domain0.8366Inherited
Cyclophilin (peptidylprolyl isomerase)0.8579Inherited
DnaQ-like 3'-5' exonuclease0.8824Inherited
Glutathione S-transferase (GST), C-terminal domain0.8854Inherited
Calmodulin-like0.8954Inherited
Leucine zipper domain0.8965Inherited
SNF-like0.9079Inherited
Extended PAW domain0.9079Inherited
Ribonuclease PH domain 1-like0.9436Inherited
Ribonuclease PH domain 2-like0.9436Inherited
NagD-like0.9436Inherited
Choline/Carnitine O-acyltransferase0.9945Inherited
RING finger domain, C3HC41Inherited
PAZ domain1Inherited
F-box domain1Inherited
Nuclear receptor ligand-binding domain1Inherited
B-box zinc-binding domain1Inherited
Glutathione peroxidase-like1Inherited
Rhodopsin-like1Inherited
N-acetyl transferase, NAT1Inherited
Nuclear receptor1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Radical SAM enzymes0Direct
Nop domain0Direct
Cadherin-like0Direct
Cullin repeat-like0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Acyl-CoA dehydrogenase NM domain-like0Direct
SMAD MH1 domain0Direct
Lamin A/C globular tail domain0Direct
AN1-like Zinc finger0Direct
Spectrin repeat0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
Hormone receptor domain0Direct
ACP-like0Direct
PEP carboxykinase N-terminal domain0Direct
FF domain0Direct
HCP-like0Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
WWE domain0Direct
Phosphoglucomutase, C-terminal domain0Direct
alpha-catenin/vinculin-like0Direct
Nucleoside diphosphate kinase, NDK0Direct
Helical domain of Sec23/240Direct
Zn-binding ribosomal proteins0Direct
Tricorn protease domain 20Direct
DEATH domain0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
Galactose mutarotase-like0Direct
PUA domain-like0Direct
Phosphoenolpyruvate/pyruvate domain0Direct
Ribokinase-like0Direct
Band 7/SPFH domain0Direct
GroEL apical domain-like0Direct
Surp module (SWAP domain)0Direct
Cdc48 domain 2-like0Direct
Ribulose-phoshate binding barrel0Direct
ArfGap/RecO-like zinc finger0Direct
MIR domain0Direct
CAD & PB1 domains0Direct
Hedgehog/intein (Hint) domain0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Glutathione synthetase ATP-binding domain-like0Direct
TK C-terminal domain-like0Direct
FAD-dependent thiol oxidase0Direct
ADP-ribosylation0Direct
LDH C-terminal domain-like0Direct
Insulin-like0Direct
Single hybrid motif0Direct
Galactose oxidase, central domain0Direct
Ribosomal protein L10Direct
PGBD-like0Direct
Second domain of FERM0Direct
MgtE membrane domain-like0Direct
Ribosomal protein S100Direct
Phosphoglucomutase, first 3 domains0Direct
Ferritin-like0Direct
Tubby C-terminal domain-like0Direct
Restriction endonuclease-like0Direct
SWIB/MDM2 domain0Direct
Chromo domain-like0Direct
Cu,Zn superoxide dismutase-like0Direct
Chitinase insertion domain0Direct
Zn-finger domain of Sec23/240Direct
Oxysterol-binding protein-like0Direct
PYP-like sensor domain (PAS domain)0Direct
t-snare proteins0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
MOSC N-terminal domain-like0Direct
PHM/PNGase F0Direct
PABC (PABP) domain0Direct
Clc chloride channel0Direct
Phoshotransferase/anion transport protein0Direct
SAND domain-like0Direct
GroES-like0Direct
Families 57/38 glycoside transferase middle domain0Direct
Ran binding protein zinc finger-like0Direct
JAB1/MPN domain0Direct
Clathrin adaptor appendage domain0Direct
ENTH/VHS domain0Direct
FtsH protease domain-like0Direct
ALDH-like0Direct
Histone-fold0Direct
PurM N-terminal domain-like0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
HSP90 C-terminal domain0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
LysM domain0Direct
Acetyl-CoA synthetase-like0Direct
PreATP-grasp domain0Direct
Cullin homology domain0Direct
HSP20-like chaperones0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Thyroglobulin type-1 domain0Direct
Domain of poly(ADP-ribose) polymerase0Direct
Integrin alpha N-terminal domain0Direct
ThrRS/AlaRS common domain0Direct
DNA repair protein MutS, domain III0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Polo-box domain0Direct
Class I glutamine amidotransferase-like0Direct
MFPT repeat-like0Direct
Tubulin C-terminal domain-like0Direct
Troponin coil-coiled subunits0Direct
Sec7 domain0Direct
NagB/RpiA/CoA transferase-like0Direct
Pepsin inhibitor-30Direct
cAMP-binding domain-like0Direct
PK beta-barrel domain-like0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Cystatin/monellin0Direct
Molybdenum cofactor-binding domain0Direct
GAT-like domain0Direct
F1F0 ATP synthase subunit C0Direct
R3H domain0Direct
eIF4e-like0Direct
Thiolase-like0Direct
Ribosomal L27 protein-like0Direct
S-adenosylmethionine synthetase0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
Ribosomal protein L10-like0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Ribosomal proteins S24e, L23 and L15e0Direct
Smc hinge domain0Direct
Kringle-like0Direct
L30e-like0Direct
Skp1 dimerisation domain-like0Direct
3-carboxy-cis,cis-mucoante lactonizing enzyme0Direct
Ribosomal protein S180Direct
Doublecortin (DC)0Direct
Profilin (actin-binding protein)0Direct
Rap/Ran-GAP0Direct
Heme-dependent peroxidases0Direct
Invertebrate chitin-binding proteins0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
CBD9-like0Direct
GYF domain0Direct
Actin-like ATPase domain0Direct
Transducin (heterotrimeric G protein), gamma chain0Direct
Diaminopimelate epimerase-like0Direct
Transducin (alpha subunit), insertion domain0Direct
SAICAR synthase-like0Direct
Nucleoporin domain0Direct
Terpenoid cyclases/Protein prenyltransferases0Direct
PEP carboxykinase-like0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
Hypothetical protein c14orf129, hspc2100Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0Direct
Aldolase0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Mitochondrial carrier0Direct
Rudiment single hybrid motif0Direct
YWTD domain0Direct
dsRNA-binding domain-like0Direct
RBP11-like subunits of RNA polymerase0Direct
Protease propeptides/inhibitors0Direct
SCP-like0Direct
YbiA-like0Direct
Citrate synthase0Direct
GroEL equatorial domain-like0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
Intermediate filament protein, coiled coil region0Direct
PIN domain-like0Direct
PurM C-terminal domain-like0Direct
SPOC domain-like0Direct
Activating enzymes of the ubiquitin-like proteins0Direct
Blood coagulation inhibitor (disintegrin)0Direct
CRAL/TRIO N-terminal domain0Direct
L-aspartase-like0Direct
ARID-like0Direct
HSP40/DnaJ peptide-binding domain0Direct
Aquaporin-like0Direct
Composite domain of metallo-dependent hydrolases0Direct
VPS9 domain0Direct
Periplasmic binding protein-like II0Direct
LEM domain0Direct
Proton glutamate symport protein0Direct
Class II aaRS ABD-related0Direct
Complement control module/SCR domain0Direct
Fibrinogen C-terminal domain-like0Direct
Cation efflux protein cytoplasmic domain-like0Direct
Carbon-nitrogen hydrolase0Direct
FAD-binding/transporter-associated domain-like0Direct
lambda repressor-like DNA-binding domains0Direct
Acyl-CoA dehydrogenase C-terminal domain-like0Direct
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
Small-conductance potassium channel0Direct
Creatinase/prolidase N-terminal domain0Direct
GroEL-intermediate domain like0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
HRDC-like0Direct
GAS2 domain-like0Direct
Acid phosphatase/Vanadium-dependent haloperoxidase0Direct
BEACH domain0Direct
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)0Direct
PEBP-like0Direct
PAP/OAS1 substrate-binding domain0Direct
Outer arm dynein light chain 10Direct
2Fe-2S ferredoxin-like0Direct
ISP domain0Direct
Bacterial exopeptidase dimerisation domain0Direct
PLC-like phosphodiesterases0Direct
beta-lactamase/transpeptidase-like0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
Elafin-like0Direct
Chaperone J-domain0Direct
Putative DNA-binding domain0Direct
Formate/glycerate dehydrogenase catalytic domain-like0Direct
WGR domain-like0Direct
alpha/beta knot0Direct
Tubulin nucleotide-binding domain-like0Direct
Arginase/deacetylase0Direct
Pentein0Direct
Nucleotidyltransferase0Direct
Retrovirus zinc finger-like domains0Direct
Integrin domains0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
SIS domain0Direct
CO dehydrogenase ISP C-domain like0Direct
Carbonic anhydrase0Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
TGS-like0Direct
Sec1/munc18-like (SM) proteins0Direct
Annexin0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Terpenoid synthases0Direct
14-3-3 protein0Direct
Carbohydrate phosphatase0Direct
Lipovitellin-phosvitin complex, superhelical domain0Direct
Tim10-like0Direct
PLP-binding barrel0Direct
Carboxypeptidase regulatory domain-like0Direct
Translational machinery components0Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0Direct
Sec63 N-terminal domain-like0Direct
Subtilisin-like0Direct
Glycolipid transfer protein, GLTP0Direct
Succinyl-CoA synthetase domains0Direct
Cytochrome c0Direct
Heme-dependent catalase-like0Direct
FAD-linked oxidases, C-terminal domain0Direct
P-loop containing nucleoside triphosphate hydrolases0.00000006269Direct
PH domain-like0.00001559Direct
PDZ domain-like0.007473Inherited
TPR-like0.01055Inherited
Periplasmic binding protein-like I0.01206Inherited
ARM repeat0.01567Inherited
ABC transporter transmembrane region0.01707Inherited
PapD-like0.0201Inherited
Protein kinase-like (PK-like)0.04005Inherited
Nucleic acid-binding proteins0.04102Inherited
Homeodomain-like0.04592Inherited
WD40 repeat-like0.05454Inherited
CCCH zinc finger0.06072Inherited
FYVE/PHD zinc finger0.06888Inherited
Translation proteins0.07633Inherited
"Winged helix" DNA-binding domain0.08457Inherited
Ankyrin repeat0.08941Inherited
HLH, helix-loop-helix DNA-binding domain0.0896Inherited
Nucleotide cyclase0.0896Inherited
SMAD/FHA domain0.09584Inherited
BRCT domain0.09584Inherited
Calcium ATPase, transmembrane domain M0.1072Inherited
SH3-domain0.1117Inherited
Regulator of G-protein signaling, RGS0.1201Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.1201Inherited
EGF/Laminin0.123Inherited
Calcium ATPase, transduction domain A0.1342Inherited
Acid proteases0.1342Inherited
Cysteine-rich domain0.1415Inherited
Quinoprotein alcohol dehydrogenase-like0.1501Inherited
Multidrug efflux transporter AcrB transmembrane domain0.1549Inherited
Cytochrome P4500.167Inherited
DBL homology domain (DH-domain)0.1678Inherited
HMG-box0.1678Inherited
ClpP/crotonase0.1678Inherited
E set domains0.171Inherited
(Trans)glycosidases0.1772Inherited
Cyclin-like0.2192Inherited
Cysteine proteinases0.2254Inherited
Bromodomain0.2334Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.2334Inherited
Tudor/PWWP/MBT0.2334Inherited
POZ domain0.2422Inherited
RNA-binding domain, RBD0.2527Inherited
Lipocalins0.2595Inherited
SNARE-like0.2605Inherited
Metallo-dependent phosphatases0.2619Inherited
Translation proteins SH3-like domain0.3231Inherited
Cation efflux protein transmembrane domain-like0.3231Inherited
PX domain0.3231Inherited
HAD-like0.3421Inherited
Nicotinic receptor ligand binding domain-like0.3545Inherited
Ubiquitin-like0.3716Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3906Inherited
RNI-like0.3971Inherited
HD-domain/PDEase-like0.3984Inherited
FKBP-like0.3984Inherited
Class II aaRS and biotin synthetases0.4143Inherited
DHS-like NAD/FAD-binding domain0.4431Inherited
Myosin rod fragments0.4431Inherited
PRTase-like0.4431Inherited
Hect, E3 ligase catalytic domain0.4431Inherited
Ribosomal protein S5 domain 2-like0.4749Inherited
Galactose-binding domain-like0.4749Inherited
WW domain0.4789Inherited
Sm-like ribonucleoproteins0.4789Inherited
Cystine-knot cytokines0.4789Inherited
SH2 domain0.4824Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.4892Inherited
Zinc beta-ribbon0.4892Inherited
Calpain large subunit, middle domain (domain III)0.4892Inherited
Riboflavin synthase domain-like0.4892Inherited
FAD/NAD(P)-binding domain0.5006Inherited
FAD-linked reductases, C-terminal domain0.5139Inherited
Voltage-gated potassium channels0.5149Inherited
Nucleotidylyl transferase0.5216Inherited
SAM/Pointed domain0.5216Inherited
SET domain0.5239Inherited
UBC-like0.5239Inherited
Seven-hairpin glycosidases0.5446Inherited
Multidrug resistance efflux transporter EmrE0.55Inherited
PLP-dependent transferases0.5676Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.5836Inherited
KA1-like0.5996Inherited
Nucleotide-binding domain0.5996Inherited
Di-copper centre-containing domain0.5996Inherited
HIT/MYND zinc finger-like0.6261Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.6272Inherited
MFS general substrate transporter0.6647Inherited
Frizzled cysteine-rich domain0.6648Inherited
4Fe-4S ferredoxins0.6648Inherited
S15/NS1 RNA-binding domain0.6648Inherited
GST C-terminal domain-like0.6707Inherited
alpha/beta-Hydrolases0.729Inherited
EF-hand0.735Inherited
Fibronectin type III0.7353Inherited
ADC-like0.7358Inherited
MIT domain0.7358Inherited
Clavaminate synthase-like0.7895Inherited
NAD kinase/diacylglycerol kinase-like0.7948Inherited
CoA-dependent acyltransferases0.8028Inherited
Cyclophilin-like0.8028Inherited
UBA-like0.8141Inherited
SNF-like0.8347Inherited
Leucine zipper domain0.8406Inherited
GTPase activation domain, GAP0.8492Inherited
Eukaryotic type KH-domain (KH-domain type I)0.8492Inherited
Thioredoxin-like0.8798Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.8892Inherited
p53-like transcription factors0.8894Inherited
Immunoglobulin0.8945Inherited
Ribonuclease PH domain 2-like0.9179Inherited
DNA/RNA polymerases0.9215Inherited
Saposin0.9441Inherited
Ribonuclease H-like0.961Inherited
PAZ domain0.9799Inherited
Ligand-binding domain in the NO signalling and Golgi transport0.9906Inherited
Bet v1-like1Inherited
B-box zinc-binding domain1Inherited
Snake toxin-like1Inherited
RING/U-box1Inherited
Family A G protein-coupled receptor-like1Inherited
Nuclear receptor ligand-binding domain1Inherited
F-box domain1Inherited
beta-beta-alpha zinc fingers1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
56112,82615
  • 56112 - Protein kinase-like (PK-like)
  • 82615 - Polo-box domain
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    50156,50044
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 0Direct
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0Direct
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0Direct
    48179,48179
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    56176,55103
  • 56176 - FAD-binding/transporter-associated domain-like
  • 55103 - FAD-linked oxidases, C-terminal domain
  • 0Direct
    51905,56425
  • 51905 - FAD/NAD(P)-binding domain
  • 56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
  • 0Direct
    161093,161093
  • 161093 - MgtE membrane domain-like
  • 161093 - MgtE membrane domain-like
  • 0Direct
    52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0Direct
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    141739,141739
  • 141739 - MFPT repeat-like
  • 141739 - MFPT repeat-like
  • 0Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0Direct
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0Direct
    51735,56327
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 56327 - LDH C-terminal domain-like
  • 0Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0Direct
    64356,49447
  • 64356 - SNARE-like
  • 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor
  • 0Direct
    46938,52087
  • 46938 - CRAL/TRIO N-terminal domain
  • 52087 - CRAL/TRIO domain
  • 0Direct
    53738,55957
  • 53738 - Phosphoglucomutase, first 3 domains
  • 55957 - Phosphoglucomutase, C-terminal domain
  • 0Direct
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    56112,48371
  • 56112 - Protein kinase-like (PK-like)
  • 48371 - ARM repeat
  • 0Direct
    52540,81271
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 81271 - TGS-like
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0Direct
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    57889,50729
  • 57889 - Cysteine-rich domain
  • 50729 - PH domain-like
  • 0Direct
    57903,82199
  • 57903 - FYVE/PHD zinc finger
  • 82199 - SET domain
  • 0Direct
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0Direct
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0Direct
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    47741,56176
  • 47741 - CO dehydrogenase ISP C-domain like
  • 56176 - FAD-binding/transporter-associated domain-like
  • 0Direct
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    52743,49785
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0Direct
    54211,55060
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55060 - GHMP Kinase, C-terminal domain
  • 0Direct
    49742,49742
  • 49742 - PHM/PNGase F
  • 49742 - PHM/PNGase F
  • 0Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0Direct
    52518,52922
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 0Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    47576,47576
  • 47576 - Calponin-homology domain, CH-domain
  • 47576 - Calponin-homology domain, CH-domain
  • 0Direct
    82615,82615
  • 82615 - Polo-box domain
  • 82615 - Polo-box domain
  • 0Direct
    55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0Direct
    53901,53901
  • 53901 - Thiolase-like
  • 53901 - Thiolase-like
  • 0Direct
    57362,57362
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 0Direct
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0Direct
    56059,52210
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52210 - Succinyl-CoA synthetase domains
  • 0Direct
    68923,53795
  • 68923 - PEP carboxykinase N-terminal domain
  • 53795 - PEP carboxykinase-like
  • 0Direct
    52047,52047
  • 52047 - RNI-like
  • 52047 - RNI-like
  • 0Direct
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    57196,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    52540,46785
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    81301,81631
  • 81301 - Nucleotidyltransferase
  • 81631 - PAP/OAS1 substrate-binding domain
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0Direct
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0Direct
    57863,48403
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0Direct
    51971,54373
  • 51971 - Nucleotide-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 0Direct
    47769,47769
  • 47769 - SAM/Pointed domain
  • 47769 - SAM/Pointed domain
  • 0Direct
    81383,52047
  • 81383 - F-box domain
  • 52047 - RNI-like
  • 0Direct
    81698,81698
  • 81698 - FF domain
  • 81698 - FF domain
  • 0Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0Direct
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    51338,51556
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 0Direct
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0Direct
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0Direct
    57414,57414
  • 57414 - Hairpin loop containing domain-like
  • 57414 - Hairpin loop containing domain-like
  • 0Direct
    55729,55729
  • 55729 - Acyl-CoA N-acyltransferases (Nat)
  • 55729 - Acyl-CoA N-acyltransferases (Nat)
  • 0Direct
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0Direct
    51445,54556
  • 51445 - (Trans)glycosidases
  • 54556 - Chitinase insertion domain
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    88713,88688
  • 88713 - Glycoside hydrolase/deacetylase
  • 88688 - Families 57/38 glycoside transferase middle domain
  • 0Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    100950,100950
  • 100950 - NagB/RpiA/CoA transferase-like
  • 100950 - NagB/RpiA/CoA transferase-like
  • 0Direct
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    48425,50729
  • 48425 - Sec7 domain
  • 50729 - PH domain-like
  • 0Direct
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0Direct
    46785,46785
  • 46785 - "Winged helix" DNA-binding domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    57889,48350
  • 57889 - Cysteine-rich domain
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    55326,56042
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 0Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    47203,47203
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    53738,53738
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 0Direct
    53187,49464
  • 53187 - Zn-dependent exopeptidases
  • 49464 - Carboxypeptidase regulatory domain-like
  • 0Direct
    51735,55347
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 0Direct
    81383,50978
  • 81383 - F-box domain
  • 50978 - WD40 repeat-like
  • 0Direct
    52518,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    54897,53187
  • 54897 - Protease propeptides/inhibitors
  • 53187 - Zn-dependent exopeptidases
  • 0Direct
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    47587,56399
  • 47587 - Domain of poly(ADP-ribose) polymerase
  • 56399 - ADP-ribosylation
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    144232,82199
  • 144232 - HIT/MYND zinc finger-like
  • 82199 - SET domain
  • 0Direct
    50129,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0Direct
    48403,52151
  • 48403 - Ankyrin repeat
  • 52151 - FabD/lysophospholipase-like
  • 0Direct
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    48464,89009
  • 48464 - ENTH/VHS domain
  • 89009 - GAT-like domain
  • 0Direct
    74650,51445
  • 74650 - Galactose mutarotase-like
  • 51445 - (Trans)glycosidases
  • 0Direct
    53187,55031
  • 53187 - Zn-dependent exopeptidases
  • 55031 - Bacterial exopeptidase dimerisation domain
  • 0Direct
    47473,103506
  • 47473 - EF-hand
  • 103506 - Mitochondrial carrier
  • 0Direct
    54236,54236
  • 54236 - Ubiquitin-like
  • 54236 - Ubiquitin-like
  • 0Direct
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0Direct
    57756,57756
  • 57756 - Retrovirus zinc finger-like domains
  • 57756 - Retrovirus zinc finger-like domains
  • 0Direct
    56601,48403
  • 56601 - beta-lactamase/transpeptidase-like
  • 48403 - Ankyrin repeat
  • 0Direct
    54665,56003
  • 54665 - CO dehydrogenase molybdoprotein N-domain-like
  • 56003 - Molybdenum cofactor-binding domain
  • 0Direct
    54897,52743
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 0Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0Direct
    52283,51735
  • 52283 - Formate/glycerate dehydrogenase catalytic domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    161111,160240
  • 161111 - Cation efflux protein transmembrane domain-like
  • 160240 - Cation efflux protein cytoplasmic domain-like
  • 0Direct
    141673,50800
  • 141673 - MOSC N-terminal domain-like
  • 50800 - PK beta-barrel domain-like
  • 0Direct
    47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    57938,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0Direct
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0Direct
    52540,140990
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 140990 - FtsH protease domain-like
  • 0Direct
    49348,55711
  • 49348 - Clathrin adaptor appendage domain
  • 55711 - Subdomain of clathrin and coatomer appendage domain
  • 0Direct
    54292,47741
  • 54292 - 2Fe-2S ferredoxin-like
  • 47741 - CO dehydrogenase ISP C-domain like
  • 0Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    51556,51338
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0Direct
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    50044,52540
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    55920,46785
  • 55920 - Creatinase/aminopeptidase
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    81324,81327
  • 81324 - Voltage-gated potassium channels
  • 81327 - Small-conductance potassium channel
  • 0Direct
    50978,50998
  • 50978 - WD40 repeat-like
  • 50998 - Quinoprotein alcohol dehydrogenase-like
  • 0Direct
    57850,117839
  • 57850 - RING/U-box
  • 117839 - WWE domain
  • 0Direct
    56672,100879
  • 56672 - DNA/RNA polymerases
  • 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain
  • 0Direct
    55394,55394
  • 55394 - Bactericidal permeability-increasing protein, BPI
  • 55394 - Bactericidal permeability-increasing protein, BPI
  • 0Direct
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    57625,57625
  • 57625 - Invertebrate chitin-binding proteins
  • 57625 - Invertebrate chitin-binding proteins
  • 0Direct
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.01707Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.07493Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.09584Inherited
    56112,55073
  • 56112 - Protein kinase-like (PK-like)
  • 55073 - Nucleotide cyclase
  • 0.1201Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.1201Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.129Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.1875Inherited
    56436,49854
  • 56436 - C-type lectin-like
  • 49854 - Spermadhesin, CUB domain
  • 0.2192Inherited
    51735,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0.2334Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.2334Inherited
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.2902Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.2902Inherited
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.3231Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.3304Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.3906Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.4474Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 0.5016Inherited
    101690,53098
  • 101690 - PAZ domain
  • 53098 - Ribonuclease H-like
  • 0.5446Inherited
    90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.5446Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.5446Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.5996Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.6648Inherited
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0.6648Inherited
    51905,54373
  • 51905 - FAD/NAD(P)-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 0.667Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.6809Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.7358Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.766Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.8028Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.8376Inherited
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0.9179Inherited
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.9215Inherited
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0.9472Inherited
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0.9472Inherited
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 1Inherited
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 1Inherited
    53300,56436
  • 53300 - vWA-like
  • 56436 - C-type lectin-like
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    56645,47203,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    46938,52087,101576
  • 46938 - CRAL/TRIO N-terminal domain
  • 52087 - CRAL/TRIO domain
  • 101576 - Supernatant protein factor (SPF), C-terminal domain
  • 0Direct
    54292,47741,56176
  • 54292 - 2Fe-2S ferredoxin-like
  • 47741 - CO dehydrogenase ISP C-domain like
  • 56176 - FAD-binding/transporter-associated domain-like
  • 0Direct
    57938,49493,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0Direct
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    50249,50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    54928,54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    81296,81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 81296 - E set domains
  • 0Direct
    56436,49854,49854
  • 56436 - C-type lectin-like
  • 49854 - Spermadhesin, CUB domain
  • 49854 - Spermadhesin, CUB domain
  • 0Direct
    50156,50044,52540
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    48371,48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    54897,52743,49785
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0Direct
    53738,53738,55957
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 55957 - Phosphoglucomutase, C-terminal domain
  • 0Direct
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0Direct
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0Direct
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0Direct
    55973,55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0Direct
    56112,82615,82615
  • 56112 - Protein kinase-like (PK-like)
  • 82615 - Polo-box domain
  • 82615 - Polo-box domain
  • 0Direct
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53738,53738,53738
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    57362,57362,57362
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 0Direct
    82895,82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    57414,57414,57414
  • 57414 - Hairpin loop containing domain-like
  • 57414 - Hairpin loop containing domain-like
  • 57414 - Hairpin loop containing domain-like
  • 0Direct
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    57625,57625,57625
  • 57625 - Invertebrate chitin-binding proteins
  • 57625 - Invertebrate chitin-binding proteins
  • 57625 - Invertebrate chitin-binding proteins
  • 0Direct
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0Direct
    50044,50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0Direct
    57567,57567,57567
  • 57567 - Serine protease inhibitors
  • 57567 - Serine protease inhibitors
  • 57567 - Serine protease inhibitors
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    51735,48179,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    74650,51445,51011
  • 74650 - Galactose mutarotase-like
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0Direct
    48452,48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0Direct
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    48726,49265,48726
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.1342Inherited
    56436,56436,49854
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 49854 - Spermadhesin, CUB domain
  • 0.3578Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.3598Inherited
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.3598Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.4431Inherited
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.8368Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9441Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.9906Inherited


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