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Worm Phenotype (WP): organism physiology variant

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Variant [WBPhenotype:0000886] <5>
+ 1:   physiology variant [WBPhenotype:0000519] <6>(494|573) (495|248|68)
0:   organism physiology variant [WBPhenotype:0000576] <10>(356|426) (357|201|60)
- 1:   organism homeostasis metabolism variant [WBPhenotype:0000577] <17>(345|413) (347|199|59)
- 1:   dauer arrest variant [WBPhenotype:0000159] <6>(9|11) (10|5|0)
- 1:   life span variant [WBPhenotype:0000039] <5>(33|31) (33|14|3)
- 1:   aging variant [WBPhenotype:0001739] <4>(1|0) (1|0|0)
- 1:   genetic pathway variant [WBPhenotype:0000074] <2>(0|0) (0|0|0)
- 1:   sexually dimorphic physiology variant [WBPhenotype:0000889] <2>(1|1) (1|0|0)
- 1:   heteroplasmy [WBPhenotype:0002121] <1>(2|1) (2|1|0)
- 1:   growth defective on low phosphate media [WBPhenotype:0002235](0|0) (0|0|0)
- 1:   larval physiology variant [WBPhenotype:0001293](0|0) (0|0|0)
- 1:   subviable [WBPhenotype:0002116](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Galactose mutarotase-like0Direct
dsRNA-binding domain-like0Direct
Nucleotidyltransferase0Direct
Formate/glycerate dehydrogenase catalytic domain-like0Direct
LysM domain0Direct
SMAD MH1 domain0Direct
Integrin alpha N-terminal domain0Direct
Lipovitellin-phosvitin complex, superhelical domain0Direct
Carboxypeptidase regulatory domain-like0Direct
Ferritin-like0Direct
Aldolase0Direct
Acyl-CoA dehydrogenase NM domain-like0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
Intermediate filament protein, coiled coil region0Direct
Clathrin adaptor appendage domain0Direct
Nop domain0Direct
GAS2 domain-like0Direct
SPOC domain-like0Direct
PHM/PNGase F0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
GroEL apical domain-like0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
Heme-dependent peroxidases0Direct
ISP domain0Direct
Cadherin-like0Direct
Nucleoside diphosphate kinase, NDK0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
GYF domain0Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0Direct
MIR domain0Direct
Acid phosphatase/Vanadium-dependent haloperoxidase0Direct
Insulin-like0Direct
Second domain of FERM0Direct
SAICAR synthase-like0Direct
PIN domain-like0Direct
Integrin domains0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
SWIB/MDM2 domain0Direct
Diaminopimelate epimerase-like0Direct
Arginase/deacetylase0Direct
Thyroglobulin type-1 domain0Direct
Cytochrome c0Direct
Clc chloride channel0Direct
Mitochondrial carrier0Direct
JAB1/MPN domain0Direct
HSP20-like chaperones0Direct
Sec7 domain0Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
BEACH domain0Direct
Nucleoporin domain0Direct
Cystatin/monellin0Direct
Glutathione synthetase ATP-binding domain-like0Direct
Putative DNA-binding domain0Direct
Chromo domain-like0Direct
Ribokinase-like0Direct
Phoshotransferase/anion transport protein0Direct
PABC (PABP) domain0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Acyl-CoA dehydrogenase C-terminal domain-like0Direct
Phosphoenolpyruvate/pyruvate domain0Direct
Ribosomal L27 protein-like0Direct
Families 57/38 glycoside transferase middle domain0Direct
WWE domain0Direct
ALDH-like0Direct
Pentein0Direct
14-3-3 protein0Direct
SCP-like0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
MFPT repeat-like0Direct
Activating enzymes of the ubiquitin-like proteins0Direct
Transducin (heterotrimeric G protein), gamma chain0Direct
Class I glutamine amidotransferase-like0Direct
Chaperone J-domain0Direct
ARID-like0Direct
ADP-ribosylation0Direct
Zn-binding ribosomal proteins0Direct
Zn-finger domain of Sec23/240Direct
eIF4e-like0Direct
Sec63 N-terminal domain-like0Direct
Blood coagulation inhibitor (disintegrin)0Direct
Cdc48 domain 2-like0Direct
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase0Direct
Surp module (SWAP domain)0Direct
Purine and uridine phosphorylases0Direct
Helical domain of Sec23/240Direct
PreATP-grasp domain0Direct
PK beta-barrel domain-like0Direct
LDH C-terminal domain-like0Direct
SAND domain-like0Direct
Phosphoglucomutase, first 3 domains0Direct
L-aspartase-like0Direct
Single hybrid motif0Direct
DEATH domain0Direct
Class II aaRS ABD-related0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
L30e-like0Direct
Fibrinogen C-terminal domain-like0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
alpha/beta knot0Direct
Outer arm dynein light chain 10Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
Polo-box domain0Direct
MgtE membrane domain-like0Direct
Composite domain of metallo-dependent hydrolases0Direct
Tubby C-terminal domain-like0Direct
WGR domain-like0Direct
DNA repair protein MutS, domain III0Direct
PEP carboxykinase N-terminal domain0Direct
Molybdenum cofactor-binding domain0Direct
Troponin coil-coiled subunits0Direct
beta-lactamase/transpeptidase-like0Direct
Glycolipid transfer protein, GLTP0Direct
Hedgehog/intein (Hint) domain0Direct
Aquaporin-like0Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0Direct
HSP40/DnaJ peptide-binding domain0Direct
CAD & PB1 domains0Direct
PAP/Archaeal CCA-adding enzyme, C-terminal domain0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Tubulin C-terminal domain-like0Direct
FF domain0Direct
cAMP-binding domain-like0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
TGS-like0Direct
Sec1/munc18-like (SM) proteins0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Profilin (actin-binding protein)0Direct
GroEL equatorial domain-like0Direct
Citrate synthase0Direct
Cu,Zn superoxide dismutase-like0Direct
Rudiment single hybrid motif0Direct
3-carboxy-cis,cis-mucoante lactonizing enzyme0Direct
Smc hinge domain0Direct
Carbon-nitrogen hydrolase0Direct
Ribulose-phoshate binding barrel0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Complement control module/SCR domain0Direct
t-snare proteins0Direct
Invertebrate chitin-binding proteins0Direct
Lamin A/C globular tail domain0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Hypothetical protein c14orf129, hspc2100Direct
Cullin homology domain0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
Subtilisin-like0Direct
Oxysterol-binding protein-like0Direct
Transducin (alpha subunit), insertion domain0Direct
PurM C-terminal domain-like0Direct
alpha-catenin/vinculin-like0Direct
Terpenoid cyclases/Protein prenyltransferases0Direct
Translational machinery components0Direct
2Fe-2S ferredoxin-like0Direct
Terpenoid synthases0Direct
Kringle-like0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
Bacterial exopeptidase dimerisation domain0Direct
Ribosomal protein L10-like0Direct
Cullin repeat-like0Direct
Annexin0Direct
YbiA-like0Direct
Proton glutamate symport protein0Direct
Creatinase/prolidase N-terminal domain0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Pepsin inhibitor-30Direct
Domain of poly(ADP-ribose) polymerase0Direct
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
ArfGap/RecO-like zinc finger0Direct
RBP11-like subunits of RNA polymerase0Direct
PEBP-like0Direct
Radical SAM enzymes0Direct
Ribosomal proteins S24e, L23 and L15e0Direct
PAP/OAS1 substrate-binding domain0Direct
Ran binding protein zinc finger-like0Direct
Doublecortin (DC)0Direct
Carbohydrate phosphatase0Direct
lambda repressor-like DNA-binding domains0Direct
Periplasmic binding protein-like II0Direct
ENTH/VHS domain0Direct
GroEL-intermediate domain like0Direct
Hormone receptor domain0Direct
MOSC N-terminal domain-like0Direct
PYP-like sensor domain (PAS domain)0Direct
PGBD-like0Direct
S-adenosylmethionine synthetase0Direct
Cation efflux protein cytoplasmic domain-like0Direct
VPS9 domain0Direct
Ribosomal protein S100Direct
FtsH protease domain-like0Direct
Elafin-like0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
HCP-like0Direct
Galactose oxidase, central domain0Direct
PLC-like phosphodiesterases0Direct
ValRS/IleRS/LeuRS editing domain0Direct
CBD9-like0Direct
Tim10-like0Direct
Heme-dependent catalase-like0Direct
ThrRS/AlaRS common domain0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
Spectrin repeat0Direct
Small-conductance potassium channel0Direct
PUA domain-like0Direct
PLP-binding barrel0Direct
GroES-like0Direct
PEP carboxykinase-like0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Tubulin nucleotide-binding domain-like0Direct
CRAL/TRIO N-terminal domain0Direct
Actin-like ATPase domain0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
HSP90 C-terminal domain0Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0Direct
Skp1 dimerisation domain-like0Direct
Succinyl-CoA synthetase domains0Direct
FAD-dependent thiol oxidase0Direct
R3H domain0Direct
Type II DNA topoisomerase0Direct
Protease propeptides/inhibitors0Direct
Rap/Ran-GAP0Direct
LEM domain0Direct
TK C-terminal domain-like0Direct
YWTD domain0Direct
Band 7/SPFH domain0Direct
Tricorn protease domain 20Direct
GAT-like domain0Direct
Ribosomal protein L10Direct
CO dehydrogenase ISP C-domain like0Direct
SIS domain0Direct
AN1-like Zinc finger0Direct
Phosphoglucomutase, C-terminal domain0Direct
Thiolase-like0Direct
Restriction endonuclease-like0Direct
PurM N-terminal domain-like0Direct
Chitinase insertion domain0Direct
Carbonic anhydrase0Direct
F1F0 ATP synthase subunit C0Direct
P-loop containing nucleoside triphosphate hydrolases0.000000141Direct
PH domain-like0.00005045Direct
Histone-fold0.0001284Direct
Protein kinase-like (PK-like)0.003944Inherited
TPR-like0.01801Inherited
Periplasmic binding protein-like I0.0197Inherited
PapD-like0.02874Inherited
ARM repeat0.03447Inherited
SH2 domain0.04538Inherited
"Winged helix" DNA-binding domain0.04721Inherited
PDZ domain-like0.04911Inherited
Homeodomain-like0.05573Inherited
WD40 repeat-like0.06617Inherited
Nucleic acid-binding proteins0.06743Inherited
Calponin-homology domain, CH-domain0.06986Inherited
Acetyl-CoA synthetase-like0.06986Inherited
Cyclin-like0.07748Inherited
CCCH zinc finger0.08584Inherited
Translation proteins0.1055Inherited
Galactose-binding domain-like0.109Inherited
Nucleotide cyclase0.1287Inherited
HLH, helix-loop-helix DNA-binding domain0.1287Inherited
SMAD/FHA domain0.1293Inherited
Acid proteases0.1293Inherited
Calcium ATPase, transmembrane domain M0.1431Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.1581Inherited
Regulator of G-protein signaling, RGS0.1581Inherited
SH3-domain0.1677Inherited
E set domains0.1706Inherited
Calcium ATPase, transduction domain A0.1752Inherited
EGF/Laminin0.1769Inherited
Quinoprotein alcohol dehydrogenase-like0.1935Inherited
Ankyrin repeat0.1944Inherited
Multidrug efflux transporter AcrB transmembrane domain0.2083Inherited
DBL homology domain (DH-domain)0.2134Inherited
ClpP/crotonase0.2358Inherited
HMG-box0.2358Inherited
(Trans)glycosidases0.2358Inherited
Cytochrome P4500.2358Inherited
POZ domain0.2744Inherited
RNA-binding domain, RBD0.2857Inherited
Bromodomain0.2864Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.2864Inherited
RNI-like0.2867Inherited
Cysteine proteinases0.2905Inherited
SNARE-like0.3151Inherited
ABC transporter transmembrane region0.3167Inherited
Lipocalins0.3265Inherited
Cation efflux protein transmembrane domain-like0.3824Inherited
Translation proteins SH3-like domain0.3824Inherited
Nicotinic receptor ligand binding domain-like0.3925Inherited
Ubiquitin-like0.4097Inherited
Cysteine-rich domain0.4246Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.4303Inherited
FKBP-like0.4318Inherited
Class II aaRS and biotin synthetases0.4912Inherited
Myosin rod fragments0.5047Inherited
DHS-like NAD/FAD-binding domain0.5047Inherited
PRTase-like0.5047Inherited
Hect, E3 ligase catalytic domain0.5047Inherited
BRCT domain0.5247Inherited
FYVE/PHD zinc finger0.5432Inherited
Ribosomal protein S5 domain 2-like0.5468Inherited
Riboflavin synthase domain-like0.5541Inherited
Calpain large subunit, middle domain (domain III)0.5541Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.5541Inherited
Cystine-knot cytokines0.5572Inherited
Sm-like ribonucleoproteins0.5572Inherited
WW domain0.5572Inherited
FAD-linked reductases, C-terminal domain0.5572Inherited
Voltage-gated potassium channels0.5595Inherited
Nucleotidylyl transferase0.5811Inherited
FAD/NAD(P)-binding domain0.5843Inherited
SET domain0.5934Inherited
Seven-hairpin glycosidases0.6041Inherited
SAM/Pointed domain0.6065Inherited
Growth factor receptor domain0.6065Inherited
UBC-like0.6173Inherited
Multidrug resistance efflux transporter EmrE0.6246Inherited
HAD-like0.6303Inherited
Osmotin, thaumatin-like protein0.6614Inherited
KA1-like0.6614Inherited
Nucleotide-binding domain0.6614Inherited
MFS general substrate transporter0.6887Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.6916Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.6992Inherited
GST C-terminal domain-like0.7144Inherited
Frizzled cysteine-rich domain0.7242Inherited
4Fe-4S ferredoxins0.7242Inherited
S15/NS1 RNA-binding domain0.7242Inherited
Ribonuclease H-like0.7521Inherited
PAZ domain0.7672Inherited
MIT domain0.7897Inherited
ADC-like0.7897Inherited
alpha/beta-Hydrolases0.8202Inherited
Fibronectin type III0.8286Inherited
Clavaminate synthase-like0.8622Inherited
EF-hand0.8653Inherited
Leucine zipper domain0.8753Inherited
GTPase activation domain, GAP0.8836Inherited
UBA-like0.8861Inherited
DNA/RNA polymerases0.9493Inherited
p53-like transcription factors0.9541Inherited
Ribonuclease PH domain 2-like0.9646Inherited
Thioredoxin-like0.9741Inherited
Immunoglobulin0.9747Inherited
Nuclear receptor ligand-binding domain0.9791Inherited
Saposin1Inherited
CoA-dependent acyltransferases1Inherited
beta-beta-alpha zinc fingers1Inherited
Family A G protein-coupled receptor-like1Inherited
Eukaryotic type KH-domain (KH-domain type I)1Inherited
Bet v1-like1Inherited
B-box zinc-binding domain1Inherited
F-box domain1Inherited
Cyclophilin-like1Inherited
Ligand-binding domain in the NO signalling and Golgi transport1Inherited
RING/U-box1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
PLC-like (P variant)0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
Biotin dependent carboxylase carboxyltransferase domain0Direct
Class I aldolase0Direct
Double-stranded RNA-binding domain (dsRBD)0Direct
Cullin repeat0Direct
IF2B-like0Direct
Fibrinogen C-terminal domain-like0Direct
Cytoplasmic domain of inward rectifier potassium channel0Direct
Sir2 family of transcriptional regulators0Direct
PEP carboxykinase N-terminal domain0Direct
Chitinase insertion domain0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
Helical domain of Sec23/240Direct
Type II chitinase0Direct
alpha-catenin/vinculin0Direct
LysM domain0Direct
PEP carboxykinase C-terminal domain0Direct
Thyroglobulin type-1 domain0Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0Direct
Succinyl-CoA synthetase domains0Direct
CO dehydrogenase flavoprotein N-terminal domain-like0Direct
BEACH domain0Direct
RNA-polymerase beta-prime0Direct
Sec1/munc18-like (SM) proteins0Direct
Ribosomal protein S100Direct
5' to 3' exonuclease catalytic domain0Direct
Peptidylglycine alpha-hydroxylating monooxygenase, PHM0Direct
Aminoacid dehydrogenase-like, C-terminal domain0Direct
UBA domain0Direct
Mitochondrial carrier0Direct
Hexokinase0Direct
Brix domain0Direct
Proton glutamate symport protein0Direct
Rap/Ran-GAP0Direct
Ribosomal protein L18 and S110Direct
Histone deacetylase, HDAC0Direct
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta0Direct
Subtilases0Direct
Regulator of chromosome condensation RCC10Direct
14-3-3 protein0Direct
Molybdenum cofactor-binding domain0Direct
acyl-CoA oxidase N-terminal domains0Direct
Blood coagulation inhibitor (disintegrin)0Direct
MFPT repeat0Direct
Hormone receptor domain0Direct
Carboxypeptidase regulatory domain0Direct
Hedgehog C-terminal (Hog) autoprocessing domain0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
Nop domain0Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
Complement control module/SCR domain0Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
Sec63 N-terminal domain0Direct
Group II chaperonin (CCT, TRIC), apical domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Insulin-like0Direct
beta 1,4 galactosyltransferase (b4GalT1)0Direct
Pyk2-associated protein beta ARF-GAP domain0Direct
YbiA-like0Direct
Alcohol dehydrogenase-like, C-terminal domain0Direct
HD domain0Direct
DEP domain0Direct
Carbonic anhydrase0Direct
MOSC N-terminal domain-like0Direct
Methionine aminopeptidase, insert domain0Direct
NHL repeat0Direct
POU-specific domain0Direct
NTF2-like0Direct
Skp1 dimerisation domain-like0Direct
Acylamino-acid-releasing enzyme, C-terminal donain0Direct
YihX-like0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
WWE domain0Direct
ALDH-like0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
L-aminoacid/polyamine oxidase0Direct
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain0Direct
Troponin I0Direct
Purine and uridine phosphorylases0Direct
Pleckstrin-homology domain (PH domain)0Direct
UDP-glucose pyrophosphorylase0Direct
Glycosyl transferases group 10Direct
Phosphate binding protein-like0Direct
Proteasome subunits0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
PDEase0Direct
Erythroid transcription factor GATA-10Direct
Spectrin repeat0Direct
SWIB/MDM2 domain0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Glycerol kinase0Direct
Thiolase-related0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
DPP6 catalytic domain-like0Direct
WGR domain0Direct
Translational machinery components0Direct
Ras-binding domain, RBD0Direct
LEM domain0Direct
GAS2 domain0Direct
MIR domain0Direct
Nucleoside diphosphate kinase, NDK0Direct
Cation efflux protein cytoplasmic domain-like0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
Fatty acid binding protein-like0Direct
D-aminoacid oxidase, N-terminal domain0Direct
Reductases0Direct
GYF domain0Direct
Polo-box duplicated region0Direct
MIF4G domain-like0Direct
Bactericidal permeability-increasing protein, BPI0Direct
Group II chaperonin (CCT, TRIC), ATPase domain0Direct
alpha-mannosidase0Direct
SCF ubiquitin ligase complex WHB domain0Direct
Armadillo repeat0Direct
Clathrin adaptor core protein0Direct
Proprotein convertase P-domain0Direct
Adenosine/AMP deaminase0Direct
Acireductone dioxygenase0Direct
HCDH C-domain-like0Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0Direct
First domain of FERM0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
acyl-CoA oxidase C-terminal domains0Direct
Poly(ADP-ribose) polymerase, C-terminal domain0Direct
YicI catalytic domain-like0Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0Direct
Cell cycle control phosphatase, catalytic domain0Direct
FF domain0Direct
Transducin (alpha subunit), insertion domain0Direct
Cyclin0Direct
cAMP-binding domain0Direct
Third domain of FERM0Direct
PurM C-terminal domain-like0Direct
Lamin A/C globular tail domain0Direct
Epoxide hydrolase0Direct
Anticodon-binding domain of Class II aaRS0Direct
Domain of poly(ADP-ribose) polymerase0Direct
Alcohol dehydrogenase-like, N-terminal domain0Direct
Acyl-carrier protein (ACP)0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
Biotinyl/lipoyl-carrier proteins and domains0Direct
CRAL/TRIO N-terminal domain0Direct
BC C-terminal domain-like0Direct
Zn-finger domain of Sec23/240Direct
Lipovitellin-phosvitin complex, superhelical domain0Direct
Ubiquitin activating enzymes (UBA)0Direct
PABC (PABP) domain0Direct
Phosphoglucomutase, first 3 domains0Direct
Quinoprotein alcohol dehydrogenase-like0Direct
Annexin0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
DNA gyrase/MutL, N-terminal domain0Direct
Hydantoinase (dihydropyrimidinase), catalytic domain0Direct
PDI-like0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
Small-conductance potassium channel0Direct
Calcium ATPase, transmembrane domain M0Direct
Gamma-glutamyltranspeptidase-like0Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
VHS domain0Direct
ATP-dependent protease Lon (La), catalytic domain0Direct
COMT-like0Direct
Doublecortin (DC)0Direct
Adenain-like0Direct
BAR domain0Direct
SMAD domain0Direct
AN1-like Zinc finger0Direct
Profilin (actin-binding protein)0Direct
Reprolysin-like0Direct
Cadherin0Direct
Ribokinase-like0Direct
Glycerophosphoryl diester phosphodiesterase0Direct
PUA domain0Direct
Poly(A) polymerase, PAP, N-terminal domain0Direct
DPP6 N-terminal domain-like0Direct
alpha-mannosidase, domain 20Direct
SAM (sterile alpha motif) domain0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain0Direct
Pancreatic carboxypeptidase, activation domain0Direct
Tubulin, GTPase domain0Direct
BC ATP-binding domain-like0Direct
PaaI/YdiI-like0Direct
Inositol polyphosphate kinase (IPK)0Direct
Ribonucleotide reductase-like0Direct
Protein prenyltransferases0Direct
Heme-dependent catalases0Direct
Class II glutamine amidotransferases0Direct
Translation initiation factor eIF4e0Direct
Laminin G-like module0Direct
Band 7/SPFH domain0Direct
HSP200Direct
Ngr ectodomain-like0Direct
a tRNA synthase domain0Direct
HEAT repeat0Direct
SMAD MH1 domain0Direct
LacY-like proton/sugar symporter0Direct
FAD-dependent thiol oxidase0Direct
Glycogenin0Direct
Arylsulfatase0Direct
RecA protein-like (ATPase-domain)0Direct
HAT/Suf repeat0Direct
beta-Lactamase/D-ala carboxypeptidase0Direct
Tim10/DDP0Direct
La domain0Direct
DEATH domain, DD0Direct
Inositol monophosphatase/fructose-1,6-bisphosphatase-like0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
CUT domain0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Poly(A) polymerase, PAP, C-terminal domain0Direct
Paired domain0Direct
Branched-chain alpha-keto acid dehydrogenase PP module0Direct
D-aminoacid oxidase-like0Direct
Ribosomal protein L10Direct
Tubulin, C-terminal domain0Direct
Chaperone J-domain0Direct
DNA repair protein MutS, domain III0Direct
Second domain of FERM0Direct
HSP90 C-terminal domain0Direct
Ran binding protein zinc finger-like0Direct
Anticodon-binding domain0Direct
Phosphatidylethanolamine binding protein0Direct
NOL1/NOP2/sun0Direct
Lactate & malate dehydrogenases, C-terminal domain0Direct
Pancreatic carboxypeptidases0Direct
CoA-binding domain0Direct
t-snare proteins0Direct
L30e/L7ae ribosomal proteins0Direct
alpha-mannosidase, C-terminal domain0Direct
AAT-like0Direct
Aquaporin-like0Direct
RNA-polymerase beta0Direct
XPF/Rad1/Mus81 nuclease0Direct
Cullin homology domain0Direct
F1F0 ATP synthase subunit C0Direct
PurM N-terminal domain-like0Direct
Matrix metalloproteases, catalytic domain0Direct
YWTD domain0Direct
PhzC/PhzF-like0Direct
Surp module (SWAP domain)0Direct
Filamin repeat (rod domain)0Direct
Mammalian PLC0Direct
S-adenosylmethionine synthetase0Direct
Sec63 C-terminal domain-like0Direct
Regulator of G-protein signaling, RGS0Direct
Actin/HSP700Direct
Hydantoinase (dihydropyrimidinase)0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
28-residue LRR0Direct
Formate/glycerate dehydrogenases, NAD-domain0Direct
Cu,Zn superoxide dismutase-like0Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0Direct
Amylase, catalytic domain0Direct
Myeloperoxidase-like0Direct
Arginine methyltransferase0Direct
Poly(A) polymerase, PAP, middle domain0Direct
Chromo domain0Direct
Oxysterol-binding protein0Direct
CAT-like0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Sterol carrier protein, SCP0Direct
ets domain0Direct
Internalin LRR domain0Direct
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)0Direct
Calpain large subunit, catalytic domain (domain II)0Direct
Hypothetical protein c14orf129, hspc2100Direct
GAPDH-like0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain0Direct
Trunk domain of Sec23/240Direct
Integrin domains0Direct
Choline kinase0Direct
1,3-glucuronyltransferase0Direct
Cdc48 domain 2-like0Direct
Smc hinge domain0Direct
Intermediate filament protein, coiled coil region0Direct
Pepsin inhibitor-30Direct
Cofilin-like0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
ValRS/IleRS/LeuRS editing domain0Direct
FtsH protease domain-like0Direct
RNA editing terminal uridyl transferase 2, RET2, domain 20Direct
RhoGDI-like0Direct
Branched-chain alpha-keto acid dehydrogenase Pyr module0Direct
Phosphoribosyltransferases (PRTases)0Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0Direct
BC N-terminal domain-like0Direct
Sec7 domain0Direct
Lesion bypass DNA polymerase (Y-family), catalytic domain0Direct
Glutaminase0Direct
Class I glutamine amidotransferases (GAT)0Direct
Acyl-CoA thioesterase0Direct
FHA domain0Direct
p120GAP domain-like0Direct
Tetraspanin0Direct
LDH N-terminal domain-like0Direct
MutT-like0Direct
DNA gyrase/MutL, second domain0Direct
Hsp90 middle domain0Direct
Phosphotyrosine-binding domain (PTB)0Direct
Glycolipid transfer protein, GLTP0Direct
Elafin-like0Direct
beta-sandwich domain of Sec23/240Direct
Arfaptin, Rac-binding fragment0Direct
Citrate synthase0Direct
Linker histone H1/H50Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Single strand DNA-binding domain, SSB0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
U-box0Direct
Bacterial exopeptidase dimerisation domain0Direct
Clathrin coat assembly domain0Direct
2Fe-2S ferredoxin domains from multidomain proteins0Direct
Nucleosome core histones0Direct
Clc chloride channel0Direct
Myotubularin-like phosphatases0Direct
AMPK-beta glycogen binding domain-like0Direct
CO dehydrogenase ISP C-domain like0Direct
Type II DNA topoisomerase0Direct
ARID domain0Direct
SWIRM domain0Direct
HSP40/DnaJ peptide-binding domain0Direct
SAND domain0Direct
Transducin (heterotrimeric G protein), gamma chain0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
Tandem AAA-ATPase domain0.0003226Direct
Protein kinases, catalytic subunit0.01091Inherited
G proteins0.03566Inherited
Homeodomain0.03756Inherited
WD40-repeat0.04776Inherited
PDZ domain0.06423Inherited
MSP-like0.06681Inherited
SH2 domain0.06969Inherited
L-arabinose binding protein-like0.07068Inherited
Acetyl-CoA synthetase-like0.08526Inherited
Calponin-homology domain, CH-domain0.08526Inherited
Canonical RBD0.09247Inherited
CCCH zinc finger0.1029Inherited
ABC transporter ATPase domain-like0.1052Inherited
Tetratricopeptide repeat (TPR)0.1403Inherited
Cold shock DNA-binding domain-like0.1501Inherited
Adenylyl and guanylyl cyclase catalytic domain0.1628Inherited
HLH, helix-loop-helix DNA-binding domain0.1628Inherited
Calcium ATPase, transduction domain A0.1981Inherited
SH3-domain0.2285Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.2377Inherited
DBL homology domain (DH-domain)0.2377Inherited
Pepsin-like0.2377Inherited
Histone lysine methyltransferases0.2377Inherited
Extended PAW domain0.2377Inherited
Elongation factors0.2377Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.2377Inherited
Acetylcholinesterase-like0.2564Inherited
Dual specificity phosphatase-like0.2603Inherited
HMG-box0.2603Inherited
EGF-type module0.2846Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.2846Inherited
Ankyrin repeat0.2977Inherited
Extended AAA-ATPase domain0.3045Inherited
Multidrug efflux transporter AcrB transmembrane domain0.3062Inherited
Bromodomain0.3111Inherited
FYVE, a phosphatidylinositol-3-phosphate binding domain0.3111Inherited
6-phosphogluconate dehydrogenase-like, N-terminal domain0.3111Inherited
Cytochrome P4500.3254Inherited
FAD/NAD-linked reductases, N-terminal and central domains0.3407Inherited
Crotonase-like0.373Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP0.373Inherited
Meta-cation ATPase, catalytic domain P0.373Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.402Inherited
Pumilio repeat0.4439Inherited
GABA-aminotransferase-like0.4439Inherited
FKBP immunophilin/proline isomerase0.458Inherited
ABC transporter transmembrane region0.4662Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.4767Inherited
Cation efflux protein transmembrane domain-like0.4831Inherited
Glutathione S-transferase (GST), N-terminal domain0.5087Inherited
Hect, E3 ligase catalytic domain0.5274Inherited
Myosin rod fragments0.5274Inherited
Pyridoxal-dependent decarboxylase0.5274Inherited
Nicotinic receptor ligand binding domain-like0.5362Inherited
I set domains0.5666Inherited
Gastric lipase0.5726Inherited
Myb/SANT domain0.5726Inherited
Calpain large subunit, middle domain (domain III)0.5726Inherited
Papain-like0.5854Inherited
WW domain0.5987Inherited
Class I alpha-1;2-mannosidase, catalytic domain0.6242Inherited
UBC-related0.6394Inherited
Synaptotagmin-like (S variant)0.6669Inherited
Osmotin, thaumatin-like protein0.6782Inherited
Ubiquitin carboxyl-terminal hydrolase, UCH0.6925Inherited
BTB/POZ domain0.7037Inherited
EF-hand modules in multidomain proteins0.7376Inherited
Frizzled cysteine-rich domain0.7376Inherited
Transforming growth factor (TGF)-beta0.7376Inherited
PHD domain0.7668Inherited
Cdc48 N-terminal domain-like0.8021Inherited
H-NOX domain0.8021Inherited
Bacterial lipase0.8021Inherited
MIT domain0.8021Inherited
Ubiquitin-related0.8031Inherited
Voltage-gated potassium channels0.8104Inherited
FAD-linked reductases, N-terminal domain0.8433Inherited
PAZ domain0.8679Inherited
LIM domain0.8802Inherited
Fibronectin type III0.8926Inherited
Glutathione S-transferase (GST), C-terminal domain0.9105Inherited
Leucine zipper domain0.919Inherited
DnaQ-like 3'-5' exonuclease0.9274Inherited
Nuclear receptor ligand-binding domain0.942Inherited
Calmodulin-like0.9424Inherited
Ribonuclease PH domain 1-like0.9772Inherited
Ribonuclease PH domain 2-like0.9772Inherited
NagD-like0.9772Inherited
Glutathione peroxidase-like1Inherited
RING finger domain, C3HC41Inherited
B-box zinc-binding domain1Inherited
Cyclophilin (peptidylprolyl isomerase)1Inherited
Choline/Carnitine O-acyltransferase1Inherited
Nuclear receptor1Inherited
F-box domain1Inherited
Rhodopsin-like1Inherited
C-type lectin domain1Inherited
N-acetyl transferase, NAT1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
PurM C-terminal domain-like0Direct
VPS9 domain0Direct
cAMP-binding domain-like0Direct
Protease propeptides/inhibitors0Direct
Terpenoid cyclases/Protein prenyltransferases0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Profilin (actin-binding protein)0Direct
Purine and uridine phosphorylases0Direct
SCP-like0Direct
Smc hinge domain0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Cystatin/monellin0Direct
Cytochrome c0Direct
Kringle-like0Direct
Second domain of FERM0Direct
Formate/glycerate dehydrogenase catalytic domain-like0Direct
lambda repressor-like DNA-binding domains0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
DEATH domain0Direct
Pepsin inhibitor-30Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
ThrRS/AlaRS common domain0Direct
Tubulin C-terminal domain-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Fibrinogen C-terminal domain-like0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
2Fe-2S ferredoxin-like0Direct
Doublecortin (DC)0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
PIN domain-like0Direct
Terpenoid synthases0Direct
beta-lactamase/transpeptidase-like0Direct
Zn-finger domain of Sec23/240Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
L-aspartase-like0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Class I glutamine amidotransferase-like0Direct
PEBP-like0Direct
PLP-binding barrel0Direct
Ribosomal protein S100Direct
Galactose mutarotase-like0Direct
Chitinase insertion domain0Direct
PLC-like phosphodiesterases0Direct
Subtilisin-like0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Band 7/SPFH domain0Direct
Putative DNA-binding domain0Direct
Sec1/munc18-like (SM) proteins0Direct
GroEL equatorial domain-like0Direct
PreATP-grasp domain0Direct
Translational machinery components0Direct
BEACH domain0Direct
Ran binding protein zinc finger-like0Direct
Integrin alpha N-terminal domain0Direct
Bacterial exopeptidase dimerisation domain0Direct
Glutathione synthetase ATP-binding domain-like0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
dsRNA-binding domain-like0Direct
Single hybrid motif0Direct
Clathrin adaptor appendage domain0Direct
PYP-like sensor domain (PAS domain)0Direct
Annexin0Direct
Pentein0Direct
Blood coagulation inhibitor (disintegrin)0Direct
HSP20-like chaperones0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Activating enzymes of the ubiquitin-like proteins0Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0Direct
Phosphoenolpyruvate/pyruvate domain0Direct
GAT-like domain0Direct
3-carboxy-cis,cis-mucoante lactonizing enzyme0Direct
Hedgehog/intein (Hint) domain0Direct
Transducin (alpha subunit), insertion domain0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Cullin homology domain0Direct
LDH C-terminal domain-like0Direct
t-snare proteins0Direct
SPOC domain-like0Direct
Rudiment single hybrid motif0Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
ALDH-like0Direct
Nucleoside diphosphate kinase, NDK0Direct
Tricorn protease domain 20Direct
SMAD MH1 domain0Direct
Surp module (SWAP domain)0Direct
Skp1 dimerisation domain-like0Direct
PHM/PNGase F0Direct
Tubby C-terminal domain-like0Direct
Acyl-CoA dehydrogenase NM domain-like0Direct
Nucleotidyltransferase0Direct
PK beta-barrel domain-like0Direct
FF domain0Direct
Thyroglobulin type-1 domain0Direct
Invertebrate chitin-binding proteins0Direct
alpha-catenin/vinculin-like0Direct
GroES-like0Direct
Domain of poly(ADP-ribose) polymerase0Direct
DNA repair protein MutS, domain III0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
MOSC N-terminal domain-like0Direct
LysM domain0Direct
Cdc48 domain 2-like0Direct
Chromo domain-like0Direct
Tim10-like0Direct
YWTD domain0Direct
CBD9-like0Direct
TK C-terminal domain-like0Direct
Composite domain of metallo-dependent hydrolases0Direct
Type II DNA topoisomerase0Direct
SAICAR synthase-like0Direct
Phoshotransferase/anion transport protein0Direct
Lipovitellin-phosvitin complex, superhelical domain0Direct
Ribosomal L27 protein-like0Direct
Cu,Zn superoxide dismutase-like0Direct
Transducin (heterotrimeric G protein), gamma chain0Direct
Families 57/38 glycoside transferase middle domain0Direct
Carbonic anhydrase0Direct
F1F0 ATP synthase subunit C0Direct
L30e-like0Direct
Rap/Ran-GAP0Direct
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)0Direct
Molybdenum cofactor-binding domain0Direct
MgtE membrane domain-like0Direct
Ribosomal protein L10Direct
Nucleoporin domain0Direct
Nop domain0Direct
alpha/beta knot0Direct
RBP11-like subunits of RNA polymerase0Direct
Troponin coil-coiled subunits0Direct
Ribokinase-like0Direct
Cadherin-like0Direct
Small-conductance potassium channel0Direct
Aquaporin-like0Direct
Cation efflux protein cytoplasmic domain-like0Direct
GYF domain0Direct
GroEL apical domain-like0Direct
Succinyl-CoA synthetase domains0Direct
Hormone receptor domain0Direct
PAP/OAS1 substrate-binding domain0Direct
FAD-dependent thiol oxidase0Direct
PUA domain-like0Direct
FtsH protease domain-like0Direct
SIS domain0Direct
Lamin A/C globular tail domain0Direct
Restriction endonuclease-like0Direct
Radical SAM enzymes0Direct
Citrate synthase0Direct
MFPT repeat-like0Direct
ENTH/VHS domain0Direct
JAB1/MPN domain0Direct
Zn-binding ribosomal proteins0Direct
WGR domain-like0Direct
Helical domain of Sec23/240Direct
Hypothetical protein c14orf129, hspc2100Direct
Carboxypeptidase regulatory domain-like0Direct
Tubulin nucleotide-binding domain-like0Direct
Ribulose-phoshate binding barrel0Direct
SWIB/MDM2 domain0Direct
PGBD-like0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
Arginase/deacetylase0Direct
Carbohydrate phosphatase0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
Heme-dependent catalase-like0Direct
eIF4e-like0Direct
Oxysterol-binding protein-like0Direct
Insulin-like0Direct
Complement control module/SCR domain0Direct
Glycolipid transfer protein, GLTP0Direct
CAD & PB1 domains0Direct
Ribosomal protein L10-like0Direct
HSP90 C-terminal domain0Direct
Cullin repeat-like0Direct
AN1-like Zinc finger0Direct
Aldolase0Direct
SAND domain-like0Direct
WWE domain0Direct
Elafin-like0Direct
LEM domain0Direct
ISP domain0Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0Direct
Mitochondrial carrier0Direct
Creatinase/prolidase N-terminal domain0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Periplasmic binding protein-like II0Direct
Acid phosphatase/Vanadium-dependent haloperoxidase0Direct
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase0Direct
ARID-like0Direct
Spectrin repeat0Direct
Clc chloride channel0Direct
TGS-like0Direct
CRAL/TRIO N-terminal domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Class II aaRS ABD-related0Direct
Ferritin-like0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
MIR domain0Direct
PAP/Archaeal CCA-adding enzyme, C-terminal domain0Direct
Galactose oxidase, central domain0Direct
Diaminopimelate epimerase-like0Direct
Actin-like ATPase domain0Direct
GAS2 domain-like0Direct
Phosphoglucomutase, C-terminal domain0Direct
PEP carboxykinase-like0Direct
PurM N-terminal domain-like0Direct
Sec63 N-terminal domain-like0Direct
HSP40/DnaJ peptide-binding domain0Direct
ArfGap/RecO-like zinc finger0Direct
Phosphoglucomutase, first 3 domains0Direct
YbiA-like0Direct
Polo-box domain0Direct
PEP carboxykinase N-terminal domain0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
GroEL-intermediate domain like0Direct
Outer arm dynein light chain 10Direct
PABC (PABP) domain0Direct
Heme-dependent peroxidases0Direct
Intermediate filament protein, coiled coil region0Direct
ADP-ribosylation0Direct
Ribosomal proteins S24e, L23 and L15e0Direct
HCP-like0Direct
R3H domain0Direct
Chaperone J-domain0Direct
14-3-3 protein0Direct
Acyl-CoA dehydrogenase C-terminal domain-like0Direct
Sec7 domain0Direct
Thiolase-like0Direct
S-adenosylmethionine synthetase0Direct
CO dehydrogenase ISP C-domain like0Direct
Proton glutamate symport protein0Direct
Carbon-nitrogen hydrolase0Direct
Integrin domains0Direct
P-loop containing nucleoside triphosphate hydrolases0.0000001124Direct
PH domain-like0.000041Direct
Histone-fold0.0001047Direct
Protein kinase-like (PK-like)0.003324Inherited
TPR-like0.01555Inherited
Periplasmic binding protein-like I0.01705Inherited
PapD-like0.02508Inherited
ARM repeat0.03018Inherited
SH2 domain0.03995Inherited
"Winged helix" DNA-binding domain0.04161Inherited
PDZ domain-like0.04332Inherited
Homeodomain-like0.04932Inherited
WD40 repeat-like0.05883Inherited
Nucleic acid-binding proteins0.05997Inherited
Calponin-homology domain, CH-domain0.06216Inherited
Acetyl-CoA synthetase-like0.06216Inherited
Cyclin-like0.06914Inherited
CCCH zinc finger0.07688Inherited
Translation proteins0.09506Inherited
Galactose-binding domain-like0.09834Inherited
HLH, helix-loop-helix DNA-binding domain0.1167Inherited
Nucleotide cyclase0.1167Inherited
Acid proteases0.1172Inherited
SMAD/FHA domain0.1172Inherited
Calcium ATPase, transmembrane domain M0.1301Inherited
Regulator of G-protein signaling, RGS0.1443Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.1443Inherited
SH3-domain0.1533Inherited
E set domains0.156Inherited
Calcium ATPase, transduction domain A0.1603Inherited
EGF/Laminin0.1619Inherited
Quinoprotein alcohol dehydrogenase-like0.1777Inherited
Ankyrin repeat0.1784Inherited
Multidrug efflux transporter AcrB transmembrane domain0.1917Inherited
DBL homology domain (DH-domain)0.1968Inherited
HMG-box0.2182Inherited
ClpP/crotonase0.2182Inherited
Cytochrome P4500.2182Inherited
(Trans)glycosidases0.2182Inherited
POZ domain0.2555Inherited
RNA-binding domain, RBD0.2664Inherited
Bromodomain0.2671Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.2671Inherited
RNI-like0.2674Inherited
Cysteine proteinases0.2711Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.2735Inherited
SNARE-like0.295Inherited
ABC transporter transmembrane region0.2965Inherited
Lipocalins0.3059Inherited
Cation efflux protein transmembrane domain-like0.3606Inherited
Translation proteins SH3-like domain0.3606Inherited
Nicotinic receptor ligand binding domain-like0.3707Inherited
Ubiquitin-like0.3877Inherited
Cysteine-rich domain0.4022Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.4078Inherited
FKBP-like0.4093Inherited
Class II aaRS and biotin synthetases0.469Inherited
Myosin rod fragments0.4824Inherited
DHS-like NAD/FAD-binding domain0.4824Inherited
Hect, E3 ligase catalytic domain0.4824Inherited
PRTase-like0.4824Inherited
BRCT domain0.5019Inherited
FYVE/PHD zinc finger0.5206Inherited
Ribosomal protein S5 domain 2-like0.5242Inherited
Riboflavin synthase domain-like0.5314Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.5314Inherited
Calpain large subunit, middle domain (domain III)0.5314Inherited
FAD-linked reductases, C-terminal domain0.5345Inherited
Sm-like ribonucleoproteins0.5345Inherited
Cystine-knot cytokines0.5345Inherited
WW domain0.5345Inherited
Voltage-gated potassium channels0.5369Inherited
Nucleotidylyl transferase0.5589Inherited
FAD/NAD(P)-binding domain0.5619Inherited
SET domain0.5711Inherited
Seven-hairpin glycosidases0.5819Inherited
SAM/Pointed domain0.5843Inherited
Growth factor receptor domain0.5843Inherited
UBC-like0.5951Inherited
Multidrug resistance efflux transporter EmrE0.6025Inherited
HAD-like0.6082Inherited
Nucleotide-binding domain0.6398Inherited
KA1-like0.6398Inherited
Osmotin, thaumatin-like protein0.6398Inherited
MFS general substrate transporter0.6674Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.6704Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.6783Inherited
GST C-terminal domain-like0.6941Inherited
Frizzled cysteine-rich domain0.7038Inherited
S15/NS1 RNA-binding domain0.7038Inherited
4Fe-4S ferredoxins0.7038Inherited
Ribonuclease H-like0.7331Inherited
PAZ domain0.7487Inherited
ADC-like0.7719Inherited
MIT domain0.7719Inherited
alpha/beta-Hydrolases0.8033Inherited
Fibronectin type III0.8122Inherited
Clavaminate synthase-like0.8474Inherited
EF-hand0.8505Inherited
Leucine zipper domain0.861Inherited
GTPase activation domain, GAP0.8696Inherited
UBA-like0.8723Inherited
DNA/RNA polymerases0.9376Inherited
p53-like transcription factors0.943Inherited
Ribonuclease PH domain 2-like0.9537Inherited
Thioredoxin-like0.9635Inherited
Immunoglobulin0.9643Inherited
Nuclear receptor ligand-binding domain0.9687Inherited
Eukaryotic type KH-domain (KH-domain type I)0.9992Inherited
Family A G protein-coupled receptor-like1Inherited
F-box domain1Inherited
Cyclophilin-like1Inherited
CoA-dependent acyltransferases1Inherited
Ligand-binding domain in the NO signalling and Golgi transport1Inherited
RING/U-box1Inherited
beta-beta-alpha zinc fingers1Inherited
Saposin1Inherited
Bet v1-like1Inherited
B-box zinc-binding domain1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
48425,50729
  • 48425 - Sec7 domain
  • 50729 - PH domain-like
  • 0Direct
    53474,53474
  • 53474 - alpha/beta-Hydrolases
  • 53474 - alpha/beta-Hydrolases
  • 0Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0Direct
    82615,82615
  • 82615 - Polo-box domain
  • 82615 - Polo-box domain
  • 0Direct
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0Direct
    49742,49742
  • 49742 - PHM/PNGase F
  • 49742 - PHM/PNGase F
  • 0Direct
    161111,160240
  • 161111 - Cation efflux protein transmembrane domain-like
  • 160240 - Cation efflux protein cytoplasmic domain-like
  • 0Direct
    51735,55347
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 0Direct
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    56059,52210
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52210 - Succinyl-CoA synthetase domains
  • 0Direct
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    74650,51445
  • 74650 - Galactose mutarotase-like
  • 51445 - (Trans)glycosidases
  • 0Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0Direct
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0Direct
    53187,49464
  • 53187 - Zn-dependent exopeptidases
  • 49464 - Carboxypeptidase regulatory domain-like
  • 0Direct
    57625,57625
  • 57625 - Invertebrate chitin-binding proteins
  • 57625 - Invertebrate chitin-binding proteins
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    57756,50630
  • 57756 - Retrovirus zinc finger-like domains
  • 50630 - Acid proteases
  • 0Direct
    53901,53901
  • 53901 - Thiolase-like
  • 53901 - Thiolase-like
  • 0Direct
    57889,48350
  • 57889 - Cysteine-rich domain
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    53187,55031
  • 53187 - Zn-dependent exopeptidases
  • 55031 - Bacterial exopeptidase dimerisation domain
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0Direct
    81698,81698
  • 81698 - FF domain
  • 81698 - FF domain
  • 0Direct
    68923,53795
  • 68923 - PEP carboxykinase N-terminal domain
  • 53795 - PEP carboxykinase-like
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    51735,50129
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 0Direct
    57889,50729
  • 57889 - Cysteine-rich domain
  • 50729 - PH domain-like
  • 0Direct
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0Direct
    53738,53738
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 0Direct
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0Direct
    57362,57362
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 0Direct
    51445,51445
  • 51445 - (Trans)glycosidases
  • 51445 - (Trans)glycosidases
  • 0Direct
    51445,54556
  • 51445 - (Trans)glycosidases
  • 54556 - Chitinase insertion domain
  • 0Direct
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0Direct
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    52518,52922
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 0Direct
    88713,88688
  • 88713 - Glycoside hydrolase/deacetylase
  • 88688 - Families 57/38 glycoside transferase middle domain
  • 0Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    52518,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    47576,47576
  • 47576 - Calponin-homology domain, CH-domain
  • 47576 - Calponin-homology domain, CH-domain
  • 0Direct
    50129,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    161093,161093
  • 161093 - MgtE membrane domain-like
  • 161093 - MgtE membrane domain-like
  • 0Direct
    81383,50978
  • 81383 - F-box domain
  • 50978 - WD40 repeat-like
  • 0Direct
    52540,140990
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 140990 - FtsH protease domain-like
  • 0Direct
    141673,50800
  • 141673 - MOSC N-terminal domain-like
  • 50800 - PK beta-barrel domain-like
  • 0Direct
    57850,117839
  • 57850 - RING/U-box
  • 117839 - WWE domain
  • 0Direct
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0Direct
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    52540,81271
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 81271 - TGS-like
  • 0Direct
    52283,51735
  • 52283 - Formate/glycerate dehydrogenase catalytic domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0Direct
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0Direct
    54665,56003
  • 54665 - CO dehydrogenase molybdoprotein N-domain-like
  • 56003 - Molybdenum cofactor-binding domain
  • 0Direct
    57903,82199
  • 57903 - FYVE/PHD zinc finger
  • 82199 - SET domain
  • 0Direct
    64356,49447
  • 64356 - SNARE-like
  • 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor
  • 0Direct
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0Direct
    57938,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    101690,53098
  • 101690 - PAZ domain
  • 53098 - Ribonuclease H-like
  • 0Direct
    54897,53187
  • 54897 - Protease propeptides/inhibitors
  • 53187 - Zn-dependent exopeptidases
  • 0Direct
    52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    57196,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0Direct
    50044,52540
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0Direct
    57863,48403
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0Direct
    51971,54373
  • 51971 - Nucleotide-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 0Direct
    57756,57756
  • 57756 - Retrovirus zinc finger-like domains
  • 57756 - Retrovirus zinc finger-like domains
  • 0Direct
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0Direct
    52540,46785
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    56601,48403
  • 56601 - beta-lactamase/transpeptidase-like
  • 48403 - Ankyrin repeat
  • 0Direct
    46938,52087
  • 46938 - CRAL/TRIO N-terminal domain
  • 52087 - CRAL/TRIO domain
  • 0Direct
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0Direct
    55394,55394
  • 55394 - Bactericidal permeability-increasing protein, BPI
  • 55394 - Bactericidal permeability-increasing protein, BPI
  • 0Direct
    51735,56327
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 56327 - LDH C-terminal domain-like
  • 0Direct
    48179,48179
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    56112,82615
  • 56112 - Protein kinase-like (PK-like)
  • 82615 - Polo-box domain
  • 0Direct
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0Direct
    52743,49785
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0Direct
    56672,100879
  • 56672 - DNA/RNA polymerases
  • 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain
  • 0Direct
    54236,54236
  • 54236 - Ubiquitin-like
  • 54236 - Ubiquitin-like
  • 0Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54897,52743
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 0Direct
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0Direct
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0Direct
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0Direct
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0Direct
    54292,47741
  • 54292 - 2Fe-2S ferredoxin-like
  • 47741 - CO dehydrogenase ISP C-domain like
  • 0Direct
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0Direct
    53738,55957
  • 53738 - Phosphoglucomutase, first 3 domains
  • 55957 - Phosphoglucomutase, C-terminal domain
  • 0Direct
    48403,52151
  • 48403 - Ankyrin repeat
  • 52151 - FabD/lysophospholipase-like
  • 0Direct
    81324,81327
  • 81324 - Voltage-gated potassium channels
  • 81327 - Small-conductance potassium channel
  • 0Direct
    55920,46785
  • 55920 - Creatinase/aminopeptidase
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    81383,52047
  • 81383 - F-box domain
  • 52047 - RNI-like
  • 0Direct
    54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0Direct
    48464,89009
  • 48464 - ENTH/VHS domain
  • 89009 - GAT-like domain
  • 0Direct
    141739,141739
  • 141739 - MFPT repeat-like
  • 141739 - MFPT repeat-like
  • 0Direct
    144232,82199
  • 144232 - HIT/MYND zinc finger-like
  • 82199 - SET domain
  • 0Direct
    55729,55729
  • 55729 - Acyl-CoA N-acyltransferases (Nat)
  • 55729 - Acyl-CoA N-acyltransferases (Nat)
  • 0Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0Direct
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    57414,57414
  • 57414 - Hairpin loop containing domain-like
  • 57414 - Hairpin loop containing domain-like
  • 0Direct
    52047,52047
  • 52047 - RNI-like
  • 52047 - RNI-like
  • 0Direct
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0Direct
    47203,47203
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0Direct
    103473,103473
  • 103473 - MFS general substrate transporter
  • 103473 - MFS general substrate transporter
  • 0Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0Direct
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0Direct
    47473,103506
  • 47473 - EF-hand
  • 103506 - Mitochondrial carrier
  • 0Direct
    55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    81631,55003
  • 81631 - PAP/OAS1 substrate-binding domain
  • 55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain
  • 0Direct
    50156,50044
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 0Direct
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0Direct
    47769,47769
  • 47769 - SAM/Pointed domain
  • 47769 - SAM/Pointed domain
  • 0Direct
    55326,56042
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 0Direct
    56112,48371
  • 56112 - Protein kinase-like (PK-like)
  • 48371 - ARM repeat
  • 0Direct
    51556,51338
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0Direct
    50978,50998
  • 50978 - WD40 repeat-like
  • 50998 - Quinoprotein alcohol dehydrogenase-like
  • 0Direct
    47587,56399
  • 47587 - Domain of poly(ADP-ribose) polymerase
  • 56399 - ADP-ribosylation
  • 0Direct
    46785,46785
  • 46785 - "Winged helix" DNA-binding domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    51905,56425
  • 51905 - FAD/NAD(P)-binding domain
  • 56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
  • 0Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    51338,51556
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 0Direct
    47741,56176
  • 47741 - CO dehydrogenase ISP C-domain like
  • 56176 - FAD-binding/transporter-associated domain-like
  • 0Direct
    81301,81631
  • 81301 - Nucleotidyltransferase
  • 81631 - PAP/OAS1 substrate-binding domain
  • 0Direct
    52047,48371
  • 52047 - RNI-like
  • 48371 - ARM repeat
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    49348,55711
  • 49348 - Clathrin adaptor appendage domain
  • 55711 - Subdomain of clathrin and coatomer appendage domain
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    54211,55060
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55060 - GHMP Kinase, C-terminal domain
  • 0Direct
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00244Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.01532Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.1172Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.1443Inherited
    56112,55073
  • 56112 - Protein kinase-like (PK-like)
  • 55073 - Nucleotide cyclase
  • 0.1443Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.1744Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.2182Inherited
    56436,49854
  • 56436 - C-type lectin-like
  • 49854 - Spermadhesin, CUB domain
  • 0.2632Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.2671Inherited
    51735,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0.2671Inherited
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0.295Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2965Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.3259Inherited
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.3259Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.3606Inherited
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.3606Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.3817Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.4078Inherited
    48403,48403
  • 48403 - Ankyrin repeat
  • 48403 - Ankyrin repeat
  • 0.4824Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.4993Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 0.5213Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.5461Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.5819Inherited
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0.6398Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.6398Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.6794Inherited
    51905,54373
  • 51905 - FAD/NAD(P)-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 0.6794Inherited
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0.7038Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.7038Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.7487Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.7719Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.8549Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9018Inherited
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0.9537Inherited
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.9622Inherited
    53300,56436
  • 53300 - vWA-like
  • 56436 - C-type lectin-like
  • 1Inherited
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 1Inherited
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 1Inherited
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48371,48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    56112,82615,82615
  • 56112 - Protein kinase-like (PK-like)
  • 82615 - Polo-box domain
  • 82615 - Polo-box domain
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    56645,47203,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    57414,57414,57414
  • 57414 - Hairpin loop containing domain-like
  • 57414 - Hairpin loop containing domain-like
  • 57414 - Hairpin loop containing domain-like
  • 0Direct
    81301,81631,55003
  • 81301 - Nucleotidyltransferase
  • 81631 - PAP/OAS1 substrate-binding domain
  • 55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain
  • 0Direct
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    48726,49265,48726
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    46938,52087,101576
  • 46938 - CRAL/TRIO N-terminal domain
  • 52087 - CRAL/TRIO domain
  • 101576 - Supernatant protein factor (SPF), C-terminal domain
  • 0Direct
    57362,57362,57362
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 0Direct
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0Direct
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    51735,48179,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    81296,81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 81296 - E set domains
  • 0Direct
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0Direct
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50044,50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    56436,49854,49854
  • 56436 - C-type lectin-like
  • 49854 - Spermadhesin, CUB domain
  • 49854 - Spermadhesin, CUB domain
  • 0Direct
    48452,48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0Direct
    50129,51735,50129
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 0Direct
    57567,57567,57567
  • 57567 - Serine protease inhibitors
  • 57567 - Serine protease inhibitors
  • 57567 - Serine protease inhibitors
  • 0Direct
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    82895,82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    54292,47741,56176
  • 54292 - 2Fe-2S ferredoxin-like
  • 47741 - CO dehydrogenase ISP C-domain like
  • 56176 - FAD-binding/transporter-associated domain-like
  • 0Direct
    63411,63411,63411
  • 63411 - LuxS/MPP-like metallohydrolase
  • 63411 - LuxS/MPP-like metallohydrolase
  • 63411 - LuxS/MPP-like metallohydrolase
  • 0Direct
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    74650,51445,51011
  • 74650 - Galactose mutarotase-like
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0Direct
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    53738,53738,53738
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 0Direct
    54928,54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    49785,49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0Direct
    57938,49493,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    53738,53738,55957
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 55957 - Phosphoglucomutase, C-terminal domain
  • 0Direct
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0Direct
    50249,50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0Direct
    54897,52743,49785
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0Direct
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    50156,50044,52540
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    57625,57625,57625
  • 57625 - Invertebrate chitin-binding proteins
  • 57625 - Invertebrate chitin-binding proteins
  • 57625 - Invertebrate chitin-binding proteins
  • 0Direct
    55973,55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.1603Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.3974Inherited
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.3974Inherited
    56436,56436,49854
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 49854 - Spermadhesin, CUB domain
  • 0.4083Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.4824Inherited
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.8793Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9877Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 1Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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