SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Worm Phenotype (WP): organism physiology variant

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Variant [WBPhenotype:0000886] <5>
+ 1:   physiology variant [WBPhenotype:0000519] <6>(495|573) (496|248|69)
0:   organism physiology variant [WBPhenotype:0000576] <10>(360|428) (362|200|61)
- 1:   organism homeostasis metabolism variant [WBPhenotype:0000577] <17>(348|415) (351|198|60)
- 1:   dauer arrest variant [WBPhenotype:0000159] <6>(10|11) (10|6|0)
- 1:   life span variant [WBPhenotype:0000039] <5>(33|32) (33|14|3)
- 1:   aging variant [WBPhenotype:0001739] <4>(1|0) (1|0|0)
- 1:   genetic pathway variant [WBPhenotype:0000074] <2>(0|0) (0|0|0)
- 1:   sexually dimorphic physiology variant [WBPhenotype:0000889] <2>(1|1) (1|0|0)
- 1:   heteroplasmy [WBPhenotype:0002121] <1>(2|1) (2|1|0)
- 1:   growth defective on low phosphate media [WBPhenotype:0002235](0|0) (0|0|0)
- 1:   larval physiology variant [WBPhenotype:0001293](0|0) (0|0|0)
- 1:   subviable [WBPhenotype:0002116](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Chaperone J-domain0Direct
GYF domain0Direct
Putative DNA-binding domain0Direct
PUA domain-like0Direct
Troponin coil-coiled subunits0Direct
YbiA-like0Direct
Actin-like ATPase domain0Direct
PLC-like phosphodiesterases0Direct
Complement control module/SCR domain0Direct
Polo-box domain0Direct
ALDH-like0Direct
Ran binding protein zinc finger-like0Direct
Glycolipid transfer protein, GLTP0Direct
Ribokinase-like0Direct
Profilin (actin-binding protein)0Direct
Phoshotransferase/anion transport protein0Direct
Succinyl-CoA synthetase domains0Direct
Integrin alpha N-terminal domain0Direct
Tricorn protease domain 20Direct
Aldolase0Direct
Sec63 N-terminal domain-like0Direct
cAMP-binding domain-like0Direct
Heme-dependent peroxidases0Direct
DNA repair protein MutS, domain III0Direct
Invertebrate chitin-binding proteins0Direct
Pentein0Direct
Rap/Ran-GAP0Direct
Phosphoglucomutase, first 3 domains0Direct
SWIB/MDM2 domain0Direct
Bacterial exopeptidase dimerisation domain0Direct
GroEL apical domain-like0Direct
Cation efflux protein cytoplasmic domain-like0Direct
Chitinase insertion domain0Direct
Skp1 dimerisation domain-like0Direct
GINS helical bundle-like0Direct
CAD & PB1 domains0Direct
Subtilisin-like0Direct
Thyroglobulin type-1 domain0Direct
Class I glutamine amidotransferase-like0Direct
LEM domain0Direct
L30e-like0Direct
Ribosomal protein L10-like0Direct
Thiolase-like0Direct
TGS-like0Direct
Doublecortin (DC)0Direct
Spectrin repeat0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
WGR domain-like0Direct
GroEL equatorial domain-like0Direct
Acid phosphatase/Vanadium-dependent haloperoxidase0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
Transducin (alpha subunit), insertion domain0Direct
PurM N-terminal domain-like0Direct
Surp module (SWAP domain)0Direct
Heme-dependent catalase-like0Direct
PAP/OAS1 substrate-binding domain0Direct
PEP carboxykinase-like0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
PK beta-barrel domain-like0Direct
Smc hinge domain0Direct
PLP-binding barrel0Direct
Insulin-like0Direct
Creatinase/prolidase N-terminal domain0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Ribosomal L27 protein-like0Direct
LDH C-terminal domain-like0Direct
BEACH domain0Direct
Small-conductance potassium channel0Direct
Carbon-nitrogen hydrolase0Direct
Tubulin C-terminal domain-like0Direct
ThrRS/AlaRS common domain0Direct
Nop domain0Direct
PurM C-terminal domain-like0Direct
Clathrin adaptor appendage domain0Direct
Hedgehog/intein (Hint) domain0Direct
Galactose mutarotase-like0Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0Direct
LysM domain0Direct
ArfGap/RecO-like zinc finger0Direct
Tubby C-terminal domain-like0Direct
Translational machinery components0Direct
R3H domain0Direct
Nucleotidyltransferase0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
Ferritin-like0Direct
MgtE membrane domain-like0Direct
Band 7/SPFH domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Hypothetical protein c14orf129, hspc2100Direct
Intermediate filament protein, coiled coil region0Direct
2Fe-2S ferredoxin-like0Direct
Galactose oxidase, central domain0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
HSP20-like chaperones0Direct
Families 57/38 glycoside transferase middle domain0Direct
Tim10-like0Direct
CBD9-like0Direct
Cullin repeat-like0Direct
Cullin homology domain0Direct
PYP-like sensor domain (PAS domain)0Direct
FAD-dependent thiol oxidase0Direct
t-snare proteins0Direct
PAP/Archaeal CCA-adding enzyme, C-terminal domain0Direct
GAS2 domain-like0Direct
Diaminopimelate epimerase-like0Direct
CO dehydrogenase ISP C-domain like0Direct
beta-lactamase/transpeptidase-like0Direct
Periplasmic binding protein-like II0Direct
PABC (PABP) domain0Direct
Rudiment single hybrid motif0Direct
RBP11-like subunits of RNA polymerase0Direct
TK C-terminal domain-like0Direct
Outer arm dynein light chain 10Direct
SMAD/FHA domain0Direct
Carbohydrate phosphatase0Direct
SMAD MH1 domain0Direct
JAB1/MPN domain0Direct
Restriction endonuclease-like0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Kringle-like0Direct
Arginase/deacetylase0Direct
HMG-box0Direct
Transducin (heterotrimeric G protein), gamma chain0Direct
S-adenosylmethionine synthetase0Direct
GAT-like domain0Direct
MIR domain0Direct
Molybdenum cofactor-binding domain0Direct
SPOC domain-like0Direct
SAND domain-like0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
GroES-like0Direct
Cu,Zn superoxide dismutase-like0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
VPS9 domain0Direct
ClpP/crotonase0Direct
FtsH protease domain-like0Direct
Citrate synthase0Direct
HSP90 C-terminal domain0Direct
Purine and uridine phosphorylases0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
F1F0 ATP synthase subunit C0Direct
Nucleoside diphosphate kinase, NDK0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
Ribosomal protein L10Direct
Second domain of FERM0Direct
ADP-ribosylation0Direct
Annexin0Direct
Calcium-dependent phosphotriesterase0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
ARID-like0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
Ribosomal protein S100Direct
YWTD domain0Direct
alpha-catenin/vinculin-like0Direct
Carboxypeptidase regulatory domain-like0Direct
Oxysterol-binding protein-like0Direct
Radical SAM enzymes0Direct
Lamin A/C globular tail domain0Direct
HCP-like0Direct
HSP40/DnaJ peptide-binding domain0Direct
FF domain0Direct
MOSC N-terminal domain-like0Direct
Acyl-CoA dehydrogenase NM domain-like0Direct
lambda repressor-like DNA-binding domains0Direct
3-carboxy-cis,cis-mucoante lactonizing enzyme0Direct
AN1-like Zinc finger0Direct
Terpenoid synthases0Direct
L-aspartase-like0Direct
Acyl-CoA dehydrogenase C-terminal domain-like0Direct
Fibrinogen C-terminal domain-like0Direct
Tubulin nucleotide-binding domain-like0Direct
Proton glutamate symport protein0Direct
Integrin domains0Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0Direct
PIN domain-like0Direct
DEATH domain0Direct
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)0Direct
Zn-binding ribosomal proteins0Direct
dsRNA-binding domain-like0Direct
GroEL-intermediate domain like0Direct
Domain of poly(ADP-ribose) polymerase0Direct
Formate/glycerate dehydrogenase catalytic domain-like0Direct
PEP carboxykinase N-terminal domain0Direct
ISP domain0Direct
PHM/PNGase F0Direct
PreATP-grasp domain0Direct
WWE domain0Direct
Class II aaRS ABD-related0Direct
Ribulose-phoshate binding barrel0Direct
CRAL/TRIO N-terminal domain0Direct
GHMP Kinase, C-terminal domain0Direct
Type II DNA topoisomerase0Direct
SAICAR synthase-like0Direct
alpha/beta knot0Direct
Elafin-like0Direct
Helical domain of Sec23/240Direct
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase0Direct
Hect, E3 ligase catalytic domain0Direct
Aquaporin-like0Direct
Sec1/munc18-like (SM) proteins0Direct
Single hybrid motif0Direct
Cytochrome c0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Alpha-L RNA-binding motif0Direct
Pepsin inhibitor-30Direct
Chromo domain-like0Direct
ENTH/VHS domain0Direct
Activating enzymes of the ubiquitin-like proteins0Direct
Protease propeptides/inhibitors0Direct
Cystatin/monellin0Direct
Phosphoglucomutase, C-terminal domain0Direct
eIF4e-like0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
PGBD-like0Direct
MFPT repeat-like0Direct
Terpenoid cyclases/Protein prenyltransferases0Direct
Cdc48 domain 2-like0Direct
Cadherin-like0Direct
SCP-like0Direct
Hormone receptor domain0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
PEBP-like0Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0Direct
Blood coagulation inhibitor (disintegrin)0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Ribosomal proteins S24e, L23 and L15e0Direct
Glutathione synthetase ATP-binding domain-like0Direct
Clc chloride channel0Direct
Mitochondrial carrier0Direct
Nucleoporin domain0Direct
Zn-finger domain of Sec23/240Direct
14-3-3 protein0Direct
Phosphoenolpyruvate/pyruvate domain0Direct
Carbonic anhydrase0Direct
SIS domain0Direct
Composite domain of metallo-dependent hydrolases0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
Sec7 domain0Direct
P-loop containing nucleoside triphosphate hydrolases0.0000002643Direct
PH domain-like0.0000866Direct
Histone-fold0.000196Direct
Protein kinase-like (PK-like)0.00946Inherited
PDZ domain-like0.01494Inherited
Nucleic acid-binding proteins0.02328Inherited
Periplasmic binding protein-like I0.02382Inherited
TPR-like0.0244Inherited
"Winged helix" DNA-binding domain0.0259Inherited
PapD-like0.03966Inherited
WD40 repeat-like0.05061Inherited
ARM repeat0.05166Inherited
SH2 domain0.05667Inherited
Homeodomain-like0.07674Inherited
Calponin-homology domain, CH-domain0.07955Inherited
Acetyl-CoA synthetase-like0.07955Inherited
Cyclin-like0.08784Inherited
CCCH zinc finger0.09686Inherited
EGF/Laminin0.09932Inherited
Translation proteins0.118Inherited
Galactose-binding domain-like0.1258Inherited
Ankyrin repeat0.13Inherited
HLH, helix-loop-helix DNA-binding domain0.1471Inherited
Nucleotide cyclase0.1471Inherited
ABC transporter transmembrane region0.1471Inherited
RNI-like0.1551Inherited
Calcium ATPase, transmembrane domain M0.1575Inherited
Regulator of G-protein signaling, RGS0.1737Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.1737Inherited
Class II aaRS and biotin synthetases0.1912Inherited
Calcium ATPase, transduction domain A0.1912Inherited
SH3-domain0.1968Inherited
E set domains0.1994Inherited
Quinoprotein alcohol dehydrogenase-like0.21Inherited
WW domain0.2311Inherited
DBL homology domain (DH-domain)0.2311Inherited
Multidrug efflux transporter AcrB transmembrane domain0.232Inherited
(Trans)glycosidases0.2768Inherited
Cytochrome P4500.2768Inherited
Multidrug resistance efflux transporter EmrE0.2788Inherited
BRCT domain0.2877Inherited
Bromodomain0.3057Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.3057Inherited
Nucleotidylyl transferase0.3302Inherited
POZ domain0.3322Inherited
SNARE-like0.3344Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.3398Inherited
Cysteine proteinases0.3412Inherited
RNA-binding domain, RBD0.3439Inherited
Ribosomal protein S5 domain 2-like0.3501Inherited
Lipocalins0.3538Inherited
SAM/Pointed domain0.3538Inherited
Translation proteins SH3-like domain0.4022Inherited
Cation efflux protein transmembrane domain-like0.4022Inherited
Acid proteases0.4321Inherited
FKBP-like0.452Inherited
Nicotinic receptor ligand binding domain-like0.453Inherited
Cysteine-rich domain0.4595Inherited
Ubiquitin-like0.4636Inherited
FYVE/PHD zinc finger0.4655Inherited
HAD-like0.4845Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.4891Inherited
DHS-like NAD/FAD-binding domain0.5241Inherited
Myosin rod fragments0.5241Inherited
PRTase-like0.5241Inherited
Riboflavin synthase domain-like0.5722Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.5722Inherited
Calpain large subunit, middle domain (domain III)0.5722Inherited
Cystine-knot cytokines0.5843Inherited
Sm-like ribonucleoproteins0.5843Inherited
FAD-linked reductases, C-terminal domain0.5843Inherited
Voltage-gated potassium channels0.6176Inherited
Seven-hairpin glycosidases0.6218Inherited
FAD/NAD(P)-binding domain0.6235Inherited
SET domain0.6299Inherited
Growth factor receptor domain0.6384Inherited
UBC-like0.6536Inherited
Clavaminate synthase-like0.667Inherited
KA1-like0.6779Inherited
Lipovitellin-phosvitin complex, superhelical domain0.6779Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.6779Inherited
Nucleotide-binding domain0.6779Inherited
Osmotin, thaumatin-like protein0.6779Inherited
MFS general substrate transporter0.686Inherited
GTPase activation domain, GAP0.7275Inherited
4Fe-4S ferredoxins0.7385Inherited
S15/NS1 RNA-binding domain0.7385Inherited
Frizzled cysteine-rich domain0.7385Inherited
GST C-terminal domain-like0.7642Inherited
PAZ domain0.7985Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.8019Inherited
Ribonuclease H-like0.8027Inherited
MIT domain0.8035Inherited
ADC-like0.8035Inherited
alpha/beta-Hydrolases0.8132Inherited
Fibronectin type III0.8595Inherited
Leucine zipper domain0.8992Inherited
UBA-like0.9103Inherited
EF-hand0.9132Inherited
DNA/RNA polymerases0.9644Inherited
p53-like transcription factors0.973Inherited
Ribonuclease PH domain 2-like0.9747Inherited
beta-beta-alpha zinc fingers0.997Inherited
Immunoglobulin0.9996Inherited
Thioredoxin-like1Inherited
Saposin1Inherited
Bet v1-like1Inherited
Nuclear receptor ligand-binding domain1Inherited
CoA-dependent acyltransferases1Inherited
B-box zinc-binding domain1Inherited
Eukaryotic type KH-domain (KH-domain type I)1Inherited
Cyclophilin-like1Inherited
F-box domain1Inherited
Family A G protein-coupled receptor-like1Inherited
Ligand-binding domain in the NO signalling and Golgi transport1Inherited
RING/U-box1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Cyclin0Direct
Hsp90 middle domain0Direct
Clathrin adaptor core protein0Direct
2Fe-2S ferredoxin domains from multidomain proteins0Direct
FHA domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
beta-Lactamase/D-ala carboxypeptidase0Direct
CoA-binding domain0Direct
NHL repeat0Direct
Class I aldolase0Direct
BC C-terminal domain-like0Direct
alpha-catenin/vinculin0Direct
Ribosomal protein L10Direct
Subtilases0Direct
HMG-box0Direct
LEM domain0Direct
1,3-glucuronyltransferase0Direct
Second domain of FERM0Direct
Phosphatidylethanolamine binding protein0Direct
RNA-polymerase beta0Direct
Calcium ATPase, transmembrane domain M0Direct
Ribokinase-like0Direct
Complement control module/SCR domain0Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0Direct
MOSC N-terminal domain-like0Direct
Biotinyl/lipoyl-carrier proteins and domains0Direct
Glycerophosphoryl diester phosphodiesterase0Direct
Biotin dependent carboxylase carboxyltransferase domain0Direct
Lesion bypass DNA polymerase (Y-family), catalytic domain0Direct
YbiA-like0Direct
Type II chitinase0Direct
Troponin I0Direct
DPP6 catalytic domain-like0Direct
alpha-mannosidase, domain 20Direct
Fatty acid binding protein-like0Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0Direct
Phosphoribosyltransferases (PRTases)0Direct
Myotubularin-like phosphatases0Direct
Erythroid transcription factor GATA-10Direct
Mammalian PLC0Direct
ets domain0Direct
DEATH domain, DD0Direct
F1F0 ATP synthase subunit C0Direct
Poly(A) polymerase, PAP, C-terminal domain0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
AMPK-beta glycogen binding domain-like0Direct
Formate/glycerate dehydrogenases, NAD-domain0Direct
Thyroglobulin type-1 domain0Direct
Aminoacid dehydrogenase-like, C-terminal domain0Direct
Lactate & malate dehydrogenases, C-terminal domain0Direct
Nucleoside diphosphate kinase, NDK0Direct
PDEase0Direct
Adenosine/AMP deaminase0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain0Direct
BC ATP-binding domain-like0Direct
Hydantoinase (dihydropyrimidinase), catalytic domain0Direct
ALDH-like0Direct
Matrix metalloproteases, catalytic domain0Direct
Blood coagulation inhibitor (disintegrin)0Direct
IF2B-like0Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0Direct
Nucleosome core histones0Direct
Pyk2-associated protein beta ARF-GAP domain0Direct
Domain of poly(ADP-ribose) polymerase0Direct
Ubiquitin activating enzymes (UBA)0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
SAND domain0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Calpain large subunit, catalytic domain (domain II)0Direct
Proprotein convertase P-domain0Direct
Single strand DNA-binding domain, SSB0Direct
28-residue LRR0Direct
Crotonase-like0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
FtsH protease domain-like0Direct
Histone deacetylase, HDAC0Direct
Methionine aminopeptidase, insert domain0Direct
beta-sandwich domain of Sec23/240Direct
HAT/Suf repeat0Direct
AAT-like0Direct
BAR domain0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain0Direct
Sec63 N-terminal domain0Direct
Acireductone dioxygenase0Direct
Armadillo repeat0Direct
a tRNA synthase domain0Direct
Reductases0Direct
ARID domain0Direct
GYF domain0Direct
Chaperone J-domain0Direct
Transducin (heterotrimeric G protein), gamma chain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
PurM N-terminal domain-like0Direct
Translational machinery components0Direct
Linker histone H1/H50Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
CO dehydrogenase flavoprotein N-terminal domain-like0Direct
Poly(A) polymerase, PAP, N-terminal domain0Direct
Sir2 family of transcriptional regulators0Direct
Hypothetical protein c14orf129, hspc2100Direct
POU-specific domain0Direct
PhzC/PhzF-like0Direct
Chromo domain0Direct
BEACH domain0Direct
SAM (sterile alpha motif) domain0Direct
Inositol polyphosphate kinase (IPK)0Direct
Branched-chain alpha-keto acid dehydrogenase PP module0Direct
Pleckstrin-homology domain (PH domain)0Direct
Hydantoinase (dihydropyrimidinase)0Direct
ValRS/IleRS/LeuRS editing domain0Direct
PDZ domain0Direct
Actin/HSP700Direct
RhoGDI-like0Direct
Acylamino-acid-releasing enzyme, C-terminal donain0Direct
D-aminoacid oxidase, N-terminal domain0Direct
Group II chaperonin (CCT, TRIC), apical domain0Direct
FF domain0Direct
Filamin repeat (rod domain)0Direct
Lamin A/C globular tail domain0Direct
Sec7 domain0Direct
Rap/Ran-GAP0Direct
Bactericidal permeability-increasing protein, BPI0Direct
cAMP-binding domain0Direct
Surp module (SWAP domain)0Direct
AN1-like Zinc finger0Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0Direct
Bacterial exopeptidase dimerisation domain0Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
Gamma-glutamyltranspeptidase-like0Direct
Anticodon-binding domain of Class II aaRS0Direct
HSP90 C-terminal domain0Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
DNA gyrase/MutL, second domain0Direct
Cytoplasmic domain of inward rectifier potassium channel0Direct
WWE domain0Direct
Chitinase insertion domain0Direct
Skp1 dimerisation domain-like0Direct
Laminin G-like module0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
HSP40/DnaJ peptide-binding domain0Direct
UDP-glucose pyrophosphorylase0Direct
CAT-like0Direct
Sec63 C-terminal domain-like0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Tetraspanin0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Protein prenyltransferases0Direct
Transducin (alpha subunit), insertion domain0Direct
Acyl-carrier protein (ACP)0Direct
beta 1,4 galactosyltransferase (b4GalT1)0Direct
UBA domain0Direct
MIR domain0Direct
Proton glutamate symport protein0Direct
Zn-finger domain of Sec23/240Direct
DNA repair protein MutS, domain III0Direct
Pepsin inhibitor-30Direct
alpha-mannosidase, C-terminal domain0Direct
Cu,Zn superoxide dismutase-like0Direct
COMT-like0Direct
Type II DNA topoisomerase0Direct
Hexokinase0Direct
GAS2 domain0Direct
Double-stranded RNA-binding domain (dsRBD)0Direct
YWTD domain0Direct
Class I glutamine amidotransferases (GAT)0Direct
Amylase, catalytic domain0Direct
Elafin-like0Direct
L-aminoacid/polyamine oxidase0Direct
NTF2-like0Direct
Intermediate filament protein, coiled coil region0Direct
Regulator of G-protein signaling, RGS0Direct
HEAT repeat0Direct
Cofilin-like0Direct
Heme-dependent catalases0Direct
Tubulin, C-terminal domain0Direct
Tubulin, GTPase domain0Direct
Poly(A) polymerase, PAP, middle domain0Direct
DNA gyrase/MutL, N-terminal domain0Direct
SMAD MH1 domain0Direct
Anticodon-binding domain0Direct
Glycosyl transferases group 10Direct
Quinoprotein alcohol dehydrogenase-like0Direct
VHS domain0Direct
DPP6 N-terminal domain-like0Direct
SWIB/MDM2 domain0Direct
Glycolipid transfer protein, GLTP0Direct
CO dehydrogenase ISP C-domain like0Direct
Doublecortin (DC)0Direct
S-adenosylmethionine synthetase0Direct
Oxysterol-binding protein0Direct
PABC (PABP) domain0Direct
Ran binding protein zinc finger-like0Direct
DEP domain0Direct
Phosphotyrosine-binding domain (PTB)0Direct
Carbonic anhydrase0Direct
Peptidylglycine alpha-hydroxylating monooxygenase, PHM0Direct
Sterol carrier protein, SCP0Direct
Arylsulfatase0Direct
Band 7/SPFH domain0Direct
Ribonucleotide reductase-like0Direct
YicI catalytic domain-like0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
Myeloperoxidase-like0Direct
Arfaptin, Rac-binding fragment0Direct
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0Direct
Alcohol dehydrogenase-like, C-terminal domain0Direct
Cdc48 domain 2-like0Direct
PUA domain0Direct
Phosphoglucomutase, first 3 domains0Direct
LDH N-terminal domain-like0Direct
t-snare proteins0Direct
14-3-3 protein0Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0Direct
Cation efflux protein cytoplasmic domain-like0Direct
WGR domain0Direct
HCDH C-domain-like0Direct
Citrate synthase0Direct
L30e/L7ae ribosomal proteins0Direct
Regulator of chromosome condensation RCC10Direct
HD domain0Direct
Purine and uridine phosphorylases0Direct
Group II chaperonin (CCT, TRIC), ATPase domain0Direct
Epoxide hydrolase0Direct
PLC-like (P variant)0Direct
First domain of FERM0Direct
La domain0Direct
Tim10/DDP0Direct
Internalin LRR domain0Direct
Cadherin0Direct
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta0Direct
Glutaminase0Direct
Trunk domain of Sec23/240Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
LysM domain0Direct
5' to 3' exonuclease catalytic domain0Direct
LacY-like proton/sugar symporter0Direct
Glycerol kinase0Direct
alpha-mannosidase0Direct
YihX-like0Direct
Translation initiation factor eIF4e0Direct
RecA protein-like (ATPase-domain)0Direct
Pancreatic carboxypeptidase, activation domain0Direct
Branched-chain alpha-keto acid dehydrogenase Pyr module0Direct
Mitochondrial carrier0Direct
Thiolase-related0Direct
MFPT repeat0Direct
PaaI/YdiI-like0Direct
PEP carboxykinase N-terminal domain0Direct
Pancreatic carboxypeptidases0Direct
Nop domain0Direct
Glycogenin0Direct
U-box0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Helical domain of Sec23/240Direct
Arginine methyltransferase0Direct
Hedgehog C-terminal (Hog) autoprocessing domain0Direct
Insulin-like0Direct
Ras-binding domain, RBD0Direct
SWIRM domain0Direct
Cell cycle control phosphatase, catalytic domain0Direct
Adenain-like0Direct
Brix domain0Direct
RNA editing terminal uridyl transferase 2, RET2, domain 20Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
FAD-dependent thiol oxidase0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Proteasome subunits0Direct
Phosphate binding protein-like0Direct
Profilin (actin-binding protein)0Direct
RNA-polymerase beta-prime0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
Polo-box duplicated region0Direct
Sec1/munc18-like (SM) proteins0Direct
D-aminoacid oxidase-like0Direct
Smc hinge domain0Direct
acyl-CoA oxidase C-terminal domains0Direct
BC N-terminal domain-like0Direct
Aquaporin-like0Direct
Ribosomal protein L18 and S110Direct
GHMP Kinase, N-terminal domain0Direct
Acyl-CoA thioesterase0Direct
Integrin domains0Direct
Inositol monophosphatase/fructose-1,6-bisphosphatase-like0Direct
AlkB-like0Direct
Cullin homology domain0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
PDI-like0Direct
Clc chloride channel0Direct
Ribosomal protein S100Direct
Spectrin repeat0Direct
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain0Direct
Carboxypeptidase regulatory domain0Direct
Alcohol dehydrogenase-like, N-terminal domain0Direct
Succinyl-CoA synthetase domains0Direct
ATP-dependent protease Lon (La), catalytic domain0Direct
Ngr ectodomain-like0Direct
Reprolysin-like0Direct
SMAD domain0Direct
HSP200Direct
PEP carboxykinase C-terminal domain0Direct
Clathrin coat assembly domain0Direct
Third domain of FERM0Direct
MIF4G domain-like0Direct
Choline kinase0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Annexin0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
Class II glutamine amidotransferases0Direct
Paired domain0Direct
Small-conductance potassium channel0Direct
MutT-like0Direct
SCF ubiquitin ligase complex WHB domain0Direct
p120GAP domain-like0Direct
Poly(ADP-ribose) polymerase, C-terminal domain0Direct
Hect, E3 ligase catalytic domain0Direct
CRAL/TRIO N-terminal domain0Direct
Cullin repeat0Direct
PurM C-terminal domain-like0Direct
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)0Direct
EGF-type module0Direct
CUT domain0Direct
acyl-CoA oxidase N-terminal domains0Direct
Hormone receptor domain0Direct
NOL1/NOP2/sun0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
Molybdenum cofactor-binding domain0Direct
Fibrinogen C-terminal domain-like0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
GAPDH-like0Direct
Tandem AAA-ATPase domain0.0004482Direct
Protein kinases, catalytic subunit0.02024Inherited
ABC transporter ATPase domain-like0.0467Inherited
Homeodomain0.04705Inherited
G proteins0.04767Inherited
WD40-repeat0.06137Inherited
L-arabinose binding protein-like0.07934Inherited
SH2 domain0.08304Inherited
MSP-like0.08306Inherited
Acetyl-CoA synthetase-like0.09502Inherited
Calponin-homology domain, CH-domain0.09502Inherited
Canonical RBD0.1139Inherited
CCCH zinc finger0.1139Inherited
Tetratricopeptide repeat (TPR)0.1578Inherited
Cold shock DNA-binding domain-like0.1634Inherited
Adenylyl and guanylyl cyclase catalytic domain0.182Inherited
HLH, helix-loop-helix DNA-binding domain0.182Inherited
Ankyrin repeat0.2051Inherited
Calcium ATPase, transduction domain A0.2131Inherited
ABC transporter transmembrane region0.239Inherited
Pepsin-like0.2542Inherited
Elongation factors0.2542Inherited
DBL homology domain (DH-domain)0.2542Inherited
Extended PAW domain0.2542Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.2542Inherited
WW domain0.2542Inherited
Histone lysine methyltransferases0.2542Inherited
SH3-domain0.2587Inherited
Dual specificity phosphatase-like0.2766Inherited
Acetylcholinesterase-like0.2837Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.3014Inherited
Bromodomain0.3296Inherited
6-phosphogluconate dehydrogenase-like, N-terminal domain0.3296Inherited
FYVE, a phosphatidylinositol-3-phosphate binding domain0.3296Inherited
Multidrug efflux transporter AcrB transmembrane domain0.3316Inherited
Extended AAA-ATPase domain0.3348Inherited
FAD/NAD-linked reductases, N-terminal and central domains0.3586Inherited
Cytochrome P4500.3679Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP0.3911Inherited
Meta-cation ATPase, catalytic domain P0.3911Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.449Inherited
Pumilio repeat0.4617Inherited
GABA-aminotransferase-like0.4617Inherited
FKBP immunophilin/proline isomerase0.4754Inherited
Cation efflux protein transmembrane domain-like0.5007Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.5027Inherited
PHD domain0.532Inherited
Pyridoxal-dependent decarboxylase0.5451Inherited
Myosin rod fragments0.5451Inherited
Glutathione S-transferase (GST), N-terminal domain0.5486Inherited
Nicotinic receptor ligand binding domain-like0.586Inherited
Myb/SANT domain0.5895Inherited
Calpain large subunit, middle domain (domain III)0.5895Inherited
Gastric lipase0.5895Inherited
I set domains0.591Inherited
Papain-like0.6162Inherited
Class I alpha-1;2-mannosidase, catalytic domain0.6396Inherited
UBC-related0.6678Inherited
Synaptotagmin-like (S variant)0.6883Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.693Inherited
Osmotin, thaumatin-like protein0.693Inherited
Lipovitellin-phosvitin complex, superhelical domain0.693Inherited
Ubiquitin carboxyl-terminal hydrolase, UCH0.7191Inherited
BTB/POZ domain0.7452Inherited
Frizzled cysteine-rich domain0.7512Inherited
Transforming growth factor (TGF)-beta0.7512Inherited
EF-hand modules in multidomain proteins0.7512Inherited
Bacterial lipase0.8119Inherited
Cdc48 N-terminal domain-like0.8119Inherited
H-NOX domain0.8119Inherited
MIT domain0.8119Inherited
Ubiquitin-related0.8269Inherited
Voltage-gated potassium channels0.848Inherited
FAD-linked reductases, N-terminal domain0.8574Inherited
PAZ domain0.8889Inherited
LIM domain0.8935Inherited
Fibronectin type III0.9172Inherited
Glutathione S-transferase (GST), C-terminal domain0.9362Inherited
Leucine zipper domain0.9363Inherited
DnaQ-like 3'-5' exonuclease0.942Inherited
Calmodulin-like0.9636Inherited
Nuclear receptor ligand-binding domain0.9835Inherited
NagD-like0.9855Inherited
Ribonuclease PH domain 2-like0.9855Inherited
Ribonuclease PH domain 1-like0.9855Inherited
RING finger domain, C3HC41Inherited
C-type lectin domain1Inherited
Glutathione peroxidase-like1Inherited
F-box domain1Inherited
Nuclear receptor1Inherited
B-box zinc-binding domain1Inherited
Cyclophilin (peptidylprolyl isomerase)1Inherited
N-acetyl transferase, NAT1Inherited
Rhodopsin-like1Inherited
Choline/Carnitine O-acyltransferase1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
beta-lactamase/transpeptidase-like0Direct
Acyl-CoA dehydrogenase NM domain-like0Direct
HSP20-like chaperones0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Doublecortin (DC)0Direct
MIR domain0Direct
Type II DNA topoisomerase0Direct
Aldolase0Direct
Clathrin adaptor appendage domain0Direct
SAND domain-like0Direct
PreATP-grasp domain0Direct
Phosphoenolpyruvate/pyruvate domain0Direct
Intermediate filament protein, coiled coil region0Direct
Sec7 domain0Direct
Glycolipid transfer protein, GLTP0Direct
Ribulose-phoshate binding barrel0Direct
Cdc48 domain 2-like0Direct
3-carboxy-cis,cis-mucoante lactonizing enzyme0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0Direct
S-adenosylmethionine synthetase0Direct
PK beta-barrel domain-like0Direct
Acyl-CoA dehydrogenase C-terminal domain-like0Direct
HMG-box0Direct
Molybdenum cofactor-binding domain0Direct
Oxysterol-binding protein-like0Direct
Mitochondrial carrier0Direct
14-3-3 protein0Direct
Sec63 N-terminal domain-like0Direct
ALDH-like0Direct
Nucleotidyltransferase0Direct
PIN domain-like0Direct
ClpP/crotonase0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
ThrRS/AlaRS common domain0Direct
Cystatin/monellin0Direct
Complement control module/SCR domain0Direct
SAICAR synthase-like0Direct
Pentein0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
Hypothetical protein c14orf129, hspc2100Direct
Phoshotransferase/anion transport protein0Direct
SMAD MH1 domain0Direct
t-snare proteins0Direct
CAD & PB1 domains0Direct
Zn-binding ribosomal proteins0Direct
Integrin domains0Direct
Cu,Zn superoxide dismutase-like0Direct
Tubulin nucleotide-binding domain-like0Direct
Creatinase/prolidase N-terminal domain0Direct
2Fe-2S ferredoxin-like0Direct
DEATH domain0Direct
ENTH/VHS domain0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
Carbon-nitrogen hydrolase0Direct
Thyroglobulin type-1 domain0Direct
Terpenoid cyclases/Protein prenyltransferases0Direct
Domain of poly(ADP-ribose) polymerase0Direct
AN1-like Zinc finger0Direct
YbiA-like0Direct
PABC (PABP) domain0Direct
FAD-dependent thiol oxidase0Direct
ArfGap/RecO-like zinc finger0Direct
LysM domain0Direct
Nucleoside diphosphate kinase, NDK0Direct
GINS helical bundle-like0Direct
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)0Direct
Zn-finger domain of Sec23/240Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Calcium-dependent phosphotriesterase0Direct
eIF4e-like0Direct
Terpenoid synthases0Direct
HSP90 C-terminal domain0Direct
WGR domain-like0Direct
HCP-like0Direct
Carbohydrate phosphatase0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
SPOC domain-like0Direct
PAP/Archaeal CCA-adding enzyme, C-terminal domain0Direct
CO dehydrogenase ISP C-domain like0Direct
GroEL apical domain-like0Direct
Clc chloride channel0Direct
Cadherin-like0Direct
Ribosomal protein L10-like0Direct
CBD9-like0Direct
RBP11-like subunits of RNA polymerase0Direct
PurM C-terminal domain-like0Direct
Lamin A/C globular tail domain0Direct
PLC-like phosphodiesterases0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
PLP-binding barrel0Direct
Succinyl-CoA synthetase domains0Direct
Heme-dependent catalase-like0Direct
lambda repressor-like DNA-binding domains0Direct
Citrate synthase0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
TK C-terminal domain-like0Direct
Single hybrid motif0Direct
Insulin-like0Direct
Chaperone J-domain0Direct
Galactose oxidase, central domain0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
Galactose mutarotase-like0Direct
Protease propeptides/inhibitors0Direct
Activating enzymes of the ubiquitin-like proteins0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Band 7/SPFH domain0Direct
Carboxypeptidase regulatory domain-like0Direct
MgtE membrane domain-like0Direct
Actin-like ATPase domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Aquaporin-like0Direct
Tubby C-terminal domain-like0Direct
Acid phosphatase/Vanadium-dependent haloperoxidase0Direct
GAT-like domain0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
CRAL/TRIO N-terminal domain0Direct
GHMP Kinase, C-terminal domain0Direct
Glutathione synthetase ATP-binding domain-like0Direct
Ribosomal protein S100Direct
Restriction endonuclease-like0Direct
Ribosomal protein L10Direct
PEP carboxykinase N-terminal domain0Direct
L30e-like0Direct
Hedgehog/intein (Hint) domain0Direct
ARID-like0Direct
Putative DNA-binding domain0Direct
Translational machinery components0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
Integrin alpha N-terminal domain0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
MOSC N-terminal domain-like0Direct
Elafin-like0Direct
Outer arm dynein light chain 10Direct
PEP carboxykinase-like0Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0Direct
Heme-dependent peroxidases0Direct
cAMP-binding domain-like0Direct
Cytochrome c0Direct
Phosphoglucomutase, first 3 domains0Direct
Pepsin inhibitor-30Direct
PEBP-like0Direct
Sec1/munc18-like (SM) proteins0Direct
Spectrin repeat0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
DNA repair protein MutS, domain III0Direct
SMAD/FHA domain0Direct
Chitinase insertion domain0Direct
ISP domain0Direct
L-aspartase-like0Direct
BEACH domain0Direct
SWIB/MDM2 domain0Direct
TGS-like0Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0Direct
Class II aaRS ABD-related0Direct
Second domain of FERM0Direct
GYF domain0Direct
Subtilisin-like0Direct
PYP-like sensor domain (PAS domain)0Direct
LDH C-terminal domain-like0Direct
JAB1/MPN domain0Direct
PurM N-terminal domain-like0Direct
Fibrinogen C-terminal domain-like0Direct
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase0Direct
Smc hinge domain0Direct
Transducin (alpha subunit), insertion domain0Direct
Ferritin-like0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Phosphoglucomutase, C-terminal domain0Direct
Ribosomal L27 protein-like0Direct
Cullin homology domain0Direct
Invertebrate chitin-binding proteins0Direct
PHM/PNGase F0Direct
FtsH protease domain-like0Direct
Radical SAM enzymes0Direct
Hormone receptor domain0Direct
Skp1 dimerisation domain-like0Direct
Class I glutamine amidotransferase-like0Direct
F1F0 ATP synthase subunit C0Direct
HSP40/DnaJ peptide-binding domain0Direct
Thiolase-like0Direct
Ribokinase-like0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Ribosomal proteins S24e, L23 and L15e0Direct
Small-conductance potassium channel0Direct
Polo-box domain0Direct
Nucleoporin domain0Direct
PAP/OAS1 substrate-binding domain0Direct
VPS9 domain0Direct
Chromo domain-like0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
GroES-like0Direct
Nop domain0Direct
Kringle-like0Direct
ADP-ribosylation0Direct
alpha-catenin/vinculin-like0Direct
GAS2 domain-like0Direct
dsRNA-binding domain-like0Direct
LEM domain0Direct
Surp module (SWAP domain)0Direct
SIS domain0Direct
Rudiment single hybrid motif0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Alpha-L RNA-binding motif0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Cation efflux protein cytoplasmic domain-like0Direct
alpha/beta knot0Direct
Transducin (heterotrimeric G protein), gamma chain0Direct
Hect, E3 ligase catalytic domain0Direct
Periplasmic binding protein-like II0Direct
Troponin coil-coiled subunits0Direct
Families 57/38 glycoside transferase middle domain0Direct
Proton glutamate symport protein0Direct
PUA domain-like0Direct
Rap/Ran-GAP0Direct
Ran binding protein zinc finger-like0Direct
Profilin (actin-binding protein)0Direct
Carbonic anhydrase0Direct
Diaminopimelate epimerase-like0Direct
SCP-like0Direct
Formate/glycerate dehydrogenase catalytic domain-like0Direct
FF domain0Direct
Bacterial exopeptidase dimerisation domain0Direct
R3H domain0Direct
Arginase/deacetylase0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
Blood coagulation inhibitor (disintegrin)0Direct
Composite domain of metallo-dependent hydrolases0Direct
Annexin0Direct
Tricorn protease domain 20Direct
GroEL equatorial domain-like0Direct
Tubulin C-terminal domain-like0Direct
MFPT repeat-like0Direct
Tim10-like0Direct
Cullin repeat-like0Direct
WWE domain0Direct
PGBD-like0Direct
Purine and uridine phosphorylases0Direct
Helical domain of Sec23/240Direct
YWTD domain0Direct
GroEL-intermediate domain like0Direct
P-loop containing nucleoside triphosphate hydrolases0.0000002118Direct
PH domain-like0.00007064Direct
Histone-fold0.0001602Direct
Protein kinase-like (PK-like)0.008081Inherited
PDZ domain-like0.01286Inherited
Nucleic acid-binding proteins0.02026Inherited
Periplasmic binding protein-like I0.02074Inherited
TPR-like0.02126Inherited
"Winged helix" DNA-binding domain0.02257Inherited
PapD-like0.03483Inherited
WD40 repeat-like0.0447Inherited
ARM repeat0.04566Inherited
SH2 domain0.05019Inherited
Homeodomain-like0.06848Inherited
Acetyl-CoA synthetase-like0.07106Inherited
Calponin-homology domain, CH-domain0.07106Inherited
Cyclin-like0.07868Inherited
CCCH zinc finger0.08704Inherited
EGF/Laminin0.0893Inherited
Translation proteins0.1066Inherited
Galactose-binding domain-like0.114Inherited
Ankyrin repeat0.1179Inherited
HLH, helix-loop-helix DNA-binding domain0.1339Inherited
ABC transporter transmembrane region0.1339Inherited
Nucleotide cyclase0.1339Inherited
RNI-like0.1415Inherited
Calcium ATPase, transmembrane domain M0.1438Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.1589Inherited
Regulator of G-protein signaling, RGS0.1589Inherited
Calcium ATPase, transduction domain A0.1754Inherited
Class II aaRS and biotin synthetases0.1754Inherited
SH3-domain0.1807Inherited
E set domains0.1833Inherited
Quinoprotein alcohol dehydrogenase-like0.1935Inherited
DBL homology domain (DH-domain)0.2136Inherited
WW domain0.2136Inherited
Multidrug efflux transporter AcrB transmembrane domain0.2146Inherited
Cytochrome P4500.2576Inherited
(Trans)glycosidases0.2576Inherited
Multidrug resistance efflux transporter EmrE0.2595Inherited
BRCT domain0.2683Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.2856Inherited
Bromodomain0.2856Inherited
Nucleotidylyl transferase0.3097Inherited
POZ domain0.3117Inherited
SNARE-like0.3139Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.3192Inherited
Cysteine proteinases0.3205Inherited
RNA-binding domain, RBD0.3232Inherited
Ribosomal protein S5 domain 2-like0.3292Inherited
Lipocalins0.333Inherited
SAM/Pointed domain0.333Inherited
Cation efflux protein transmembrane domain-like0.3801Inherited
Translation proteins SH3-like domain0.3801Inherited
Acid proteases0.4098Inherited
Tropomyosin0.4171Inherited
FKBP-like0.4293Inherited
Nicotinic receptor ligand binding domain-like0.4302Inherited
Cysteine-rich domain0.4367Inherited
Ubiquitin-like0.4407Inherited
FYVE/PHD zinc finger0.4427Inherited
HAD-like0.462Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.4665Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.4665Inherited
PRTase-like0.5016Inherited
Myosin rod fragments0.5016Inherited
DHS-like NAD/FAD-binding domain0.5016Inherited
Riboflavin synthase domain-like0.5499Inherited
Calpain large subunit, middle domain (domain III)0.5499Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.5499Inherited
FAD-linked reductases, C-terminal domain0.562Inherited
Sm-like ribonucleoproteins0.562Inherited
Cystine-knot cytokines0.562Inherited
Voltage-gated potassium channels0.5956Inherited
Seven-hairpin glycosidases0.5998Inherited
FAD/NAD(P)-binding domain0.6015Inherited
SET domain0.6081Inherited
Growth factor receptor domain0.6168Inherited
UBC-like0.6322Inherited
Clavaminate synthase-like0.6458Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.6566Inherited
KA1-like0.6566Inherited
Nucleotide-binding domain0.6566Inherited
Osmotin, thaumatin-like protein0.6566Inherited
Lipovitellin-phosvitin complex, superhelical domain0.6566Inherited
MFS general substrate transporter0.665Inherited
GTPase activation domain, GAP0.7077Inherited
S15/NS1 RNA-binding domain0.719Inherited
4Fe-4S ferredoxins0.719Inherited
Frizzled cysteine-rich domain0.719Inherited
GST C-terminal domain-like0.7454Inherited
PAZ domain0.7808Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.7843Inherited
Ribonuclease H-like0.7852Inherited
ADC-like0.7861Inherited
MIT domain0.7861Inherited
alpha/beta-Hydrolases0.796Inherited
Fibronectin type III0.8448Inherited
Leucine zipper domain0.886Inherited
UBA-like0.8974Inherited
EF-hand0.9004Inherited
DNA/RNA polymerases0.9538Inherited
p53-like transcription factors0.963Inherited
Ribonuclease PH domain 2-like0.9648Inherited
beta-beta-alpha zinc fingers0.9874Inherited
Immunoglobulin0.9902Inherited
Thioredoxin-like0.9989Inherited
Saposin1Inherited
CoA-dependent acyltransferases1Inherited
Ligand-binding domain in the NO signalling and Golgi transport1Inherited
Nuclear receptor ligand-binding domain1Inherited
Bet v1-like1Inherited
Eukaryotic type KH-domain (KH-domain type I)1Inherited
RING/U-box1Inherited
F-box domain1Inherited
B-box zinc-binding domain1Inherited
Cyclophilin-like1Inherited
Family A G protein-coupled receptor-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54897,52743
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 0Direct
    103473,103473
  • 103473 - MFS general substrate transporter
  • 103473 - MFS general substrate transporter
  • 0Direct
    57889,50729
  • 57889 - Cysteine-rich domain
  • 50729 - PH domain-like
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    46785,46785
  • 46785 - "Winged helix" DNA-binding domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    53738,55957
  • 53738 - Phosphoglucomutase, first 3 domains
  • 55957 - Phosphoglucomutase, C-terminal domain
  • 0Direct
    52283,51735
  • 52283 - Formate/glycerate dehydrogenase catalytic domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    51445,54556
  • 51445 - (Trans)glycosidases
  • 54556 - Chitinase insertion domain
  • 0Direct
    50044,52540
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    55920,46785
  • 55920 - Creatinase/aminopeptidase
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    56112,48371
  • 56112 - Protein kinase-like (PK-like)
  • 48371 - ARM repeat
  • 0Direct
    56601,48403
  • 56601 - beta-lactamase/transpeptidase-like
  • 48403 - Ankyrin repeat
  • 0Direct
    81324,81327
  • 81324 - Voltage-gated potassium channels
  • 81327 - Small-conductance potassium channel
  • 0Direct
    50978,50998
  • 50978 - WD40 repeat-like
  • 50998 - Quinoprotein alcohol dehydrogenase-like
  • 0Direct
    51971,54373
  • 51971 - Nucleotide-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 0Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    54897,53187
  • 54897 - Protease propeptides/inhibitors
  • 53187 - Zn-dependent exopeptidases
  • 0Direct
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0Direct
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0Direct
    161111,160240
  • 161111 - Cation efflux protein transmembrane domain-like
  • 160240 - Cation efflux protein cytoplasmic domain-like
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0Direct
    64356,49447
  • 64356 - SNARE-like
  • 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor
  • 0Direct
    54292,47741
  • 54292 - 2Fe-2S ferredoxin-like
  • 47741 - CO dehydrogenase ISP C-domain like
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    81383,52047
  • 81383 - F-box domain
  • 52047 - RNI-like
  • 0Direct
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    47587,56399
  • 47587 - Domain of poly(ADP-ribose) polymerase
  • 56399 - ADP-ribosylation
  • 0Direct
    56672,100879
  • 56672 - DNA/RNA polymerases
  • 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain
  • 0Direct
    57756,50630
  • 57756 - Retrovirus zinc finger-like domains
  • 50630 - Acid proteases
  • 0Direct
    161093,161093
  • 161093 - MgtE membrane domain-like
  • 161093 - MgtE membrane domain-like
  • 0Direct
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0Direct
    51735,55347
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 0Direct
    54211,55060
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55060 - GHMP Kinase, C-terminal domain
  • 0Direct
    47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0Direct
    57414,57414
  • 57414 - Hairpin loop containing domain-like
  • 57414 - Hairpin loop containing domain-like
  • 0Direct
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    54665,56003
  • 54665 - CO dehydrogenase molybdoprotein N-domain-like
  • 56003 - Molybdenum cofactor-binding domain
  • 0Direct
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    88713,88688
  • 88713 - Glycoside hydrolase/deacetylase
  • 88688 - Families 57/38 glycoside transferase middle domain
  • 0Direct
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0Direct
    51445,51445
  • 51445 - (Trans)glycosidases
  • 51445 - (Trans)glycosidases
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0Direct
    53901,53901
  • 53901 - Thiolase-like
  • 53901 - Thiolase-like
  • 0Direct
    55394,55394
  • 55394 - Bactericidal permeability-increasing protein, BPI
  • 55394 - Bactericidal permeability-increasing protein, BPI
  • 0Direct
    47473,103506
  • 47473 - EF-hand
  • 103506 - Mitochondrial carrier
  • 0Direct
    46938,52087
  • 46938 - CRAL/TRIO N-terminal domain
  • 52087 - CRAL/TRIO domain
  • 0Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    47769,47769
  • 47769 - SAM/Pointed domain
  • 47769 - SAM/Pointed domain
  • 0Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    49742,49742
  • 49742 - PHM/PNGase F
  • 49742 - PHM/PNGase F
  • 0Direct
    53187,55031
  • 53187 - Zn-dependent exopeptidases
  • 55031 - Bacterial exopeptidase dimerisation domain
  • 0Direct
    50129,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    47203,47203
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    144232,82199
  • 144232 - HIT/MYND zinc finger-like
  • 82199 - SET domain
  • 0Direct
    57850,117839
  • 57850 - RING/U-box
  • 117839 - WWE domain
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    52518,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    57938,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    51735,56327
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 56327 - LDH C-terminal domain-like
  • 0Direct
    54236,54236
  • 54236 - Ubiquitin-like
  • 54236 - Ubiquitin-like
  • 0Direct
    48179,48179
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    51556,51338
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0Direct
    82615,82615
  • 82615 - Polo-box domain
  • 82615 - Polo-box domain
  • 0Direct
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0Direct
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0Direct
    52540,46785
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0Direct
    54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0Direct
    81301,81631
  • 81301 - Nucleotidyltransferase
  • 81631 - PAP/OAS1 substrate-binding domain
  • 0Direct
    55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    141673,50800
  • 141673 - MOSC N-terminal domain-like
  • 50800 - PK beta-barrel domain-like
  • 0Direct
    81698,81698
  • 81698 - FF domain
  • 81698 - FF domain
  • 0Direct
    53187,49464
  • 53187 - Zn-dependent exopeptidases
  • 49464 - Carboxypeptidase regulatory domain-like
  • 0Direct
    53738,53738
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 0Direct
    81631,55003
  • 81631 - PAP/OAS1 substrate-binding domain
  • 55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain
  • 0Direct
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0Direct
    57362,57362
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 0Direct
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0Direct
    48403,52151
  • 48403 - Ankyrin repeat
  • 52151 - FabD/lysophospholipase-like
  • 0Direct
    52047,48371
  • 52047 - RNI-like
  • 48371 - ARM repeat
  • 0Direct
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0Direct
    51905,56425
  • 51905 - FAD/NAD(P)-binding domain
  • 56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    101690,53098
  • 101690 - PAZ domain
  • 53098 - Ribonuclease H-like
  • 0Direct
    57903,82199
  • 57903 - FYVE/PHD zinc finger
  • 82199 - SET domain
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    52518,52922
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 0Direct
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0Direct
    53474,53474
  • 53474 - alpha/beta-Hydrolases
  • 53474 - alpha/beta-Hydrolases
  • 0Direct
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0Direct
    55729,55729
  • 55729 - Acyl-CoA N-acyltransferases (Nat)
  • 55729 - Acyl-CoA N-acyltransferases (Nat)
  • 0Direct
    52047,52047
  • 52047 - RNI-like
  • 52047 - RNI-like
  • 0Direct
    52743,49785
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0Direct
    52540,81271
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 81271 - TGS-like
  • 0Direct
    48464,89009
  • 48464 - ENTH/VHS domain
  • 89009 - GAT-like domain
  • 0Direct
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    56112,82615
  • 56112 - Protein kinase-like (PK-like)
  • 82615 - Polo-box domain
  • 0Direct
    50156,50044
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    57196,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0Direct
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0Direct
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0Direct
    49348,55711
  • 49348 - Clathrin adaptor appendage domain
  • 55711 - Subdomain of clathrin and coatomer appendage domain
  • 0Direct
    55326,56042
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 0Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    57889,48350
  • 57889 - Cysteine-rich domain
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    48425,50729
  • 48425 - Sec7 domain
  • 50729 - PH domain-like
  • 0Direct
    74650,51445
  • 74650 - Galactose mutarotase-like
  • 51445 - (Trans)glycosidases
  • 0Direct
    68923,53795
  • 68923 - PEP carboxykinase N-terminal domain
  • 53795 - PEP carboxykinase-like
  • 0Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0Direct
    57756,57756
  • 57756 - Retrovirus zinc finger-like domains
  • 57756 - Retrovirus zinc finger-like domains
  • 0Direct
    57863,48403
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0Direct
    47741,56176
  • 47741 - CO dehydrogenase ISP C-domain like
  • 56176 - FAD-binding/transporter-associated domain-like
  • 0Direct
    81383,50978
  • 81383 - F-box domain
  • 50978 - WD40 repeat-like
  • 0Direct
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    51735,50129
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 0Direct
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0Direct
    56059,52210
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52210 - Succinyl-CoA synthetase domains
  • 0Direct
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0Direct
    51338,51556
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0Direct
    141739,141739
  • 141739 - MFPT repeat-like
  • 141739 - MFPT repeat-like
  • 0Direct
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    52540,140990
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 140990 - FtsH protease domain-like
  • 0Direct
    57625,57625
  • 57625 - Invertebrate chitin-binding proteins
  • 57625 - Invertebrate chitin-binding proteins
  • 0Direct
    47576,47576
  • 47576 - Calponin-homology domain, CH-domain
  • 47576 - Calponin-homology domain, CH-domain
  • 0Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0Direct
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0Direct
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.003231Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.01868Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.1301Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1339Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.1589Inherited
    56112,55073
  • 56112 - Protein kinase-like (PK-like)
  • 55073 - Nucleotide cyclase
  • 0.1589Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.2039Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.2355Inherited
    51735,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0.2856Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.2856Inherited
    56436,49854
  • 56436 - C-type lectin-like
  • 49854 - Spermadhesin, CUB domain
  • 0.2887Inherited
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0.3139Inherited
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.3456Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.3456Inherited
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.3801Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.4098Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.4665Inherited
    48403,48403
  • 48403 - Ankyrin repeat
  • 48403 - Ankyrin repeat
  • 0.5016Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.5276Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.5365Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 0.5733Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.5998Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.6114Inherited
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0.6566Inherited
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.6566Inherited
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0.6566Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.7038Inherited
    51905,54373
  • 51905 - FAD/NAD(P)-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 0.7038Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.719Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.7861Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.8764Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9281Inherited
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0.9648Inherited
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.9756Inherited
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 1Inherited
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 1Inherited
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 1Inherited
    53300,56436
  • 53300 - vWA-like
  • 56436 - C-type lectin-like
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    55973,55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    48726,49265,48726
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    53738,53738,53738
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 0Direct
    57625,57625,57625
  • 57625 - Invertebrate chitin-binding proteins
  • 57625 - Invertebrate chitin-binding proteins
  • 57625 - Invertebrate chitin-binding proteins
  • 0Direct
    56436,49854,49854
  • 56436 - C-type lectin-like
  • 49854 - Spermadhesin, CUB domain
  • 49854 - Spermadhesin, CUB domain
  • 0Direct
    46938,52087,101576
  • 46938 - CRAL/TRIO N-terminal domain
  • 52087 - CRAL/TRIO domain
  • 101576 - Supernatant protein factor (SPF), C-terminal domain
  • 0Direct
    48452,48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    56645,47203,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    57938,49493,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0Direct
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0Direct
    54897,52743,49785
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0Direct
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0Direct
    50156,50044,52540
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    81301,81631,55003
  • 81301 - Nucleotidyltransferase
  • 81631 - PAP/OAS1 substrate-binding domain
  • 55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain
  • 0Direct
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    56112,82615,82615
  • 56112 - Protein kinase-like (PK-like)
  • 82615 - Polo-box domain
  • 82615 - Polo-box domain
  • 0Direct
    74650,51445,51011
  • 74650 - Galactose mutarotase-like
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0Direct
    57414,57414,57414
  • 57414 - Hairpin loop containing domain-like
  • 57414 - Hairpin loop containing domain-like
  • 57414 - Hairpin loop containing domain-like
  • 0Direct
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    63411,63411,63411
  • 63411 - LuxS/MPP-like metallohydrolase
  • 63411 - LuxS/MPP-like metallohydrolase
  • 63411 - LuxS/MPP-like metallohydrolase
  • 0Direct
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    57362,57362,57362
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 0Direct
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    50044,50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0Direct
    51735,48179,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    50249,50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    54292,47741,56176
  • 54292 - 2Fe-2S ferredoxin-like
  • 47741 - CO dehydrogenase ISP C-domain like
  • 56176 - FAD-binding/transporter-associated domain-like
  • 0Direct
    57567,57567,57567
  • 57567 - Serine protease inhibitors
  • 57567 - Serine protease inhibitors
  • 57567 - Serine protease inhibitors
  • 0Direct
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0Direct
    49785,49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0Direct
    82895,82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    54928,54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0Direct
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    81296,81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 81296 - E set domains
  • 0Direct
    53738,53738,55957
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 55957 - Phosphoglucomutase, C-terminal domain
  • 0Direct
    50129,51735,50129
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 0Direct
    48371,48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0Direct
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.1754Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.4171Inherited
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.4171Inherited
    56436,56436,49854
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 49854 - Spermadhesin, CUB domain
  • 0.4367Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.5016Inherited
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.6566Inherited
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.8957Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 1Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 1Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 1Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)