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Worm Phenotype (WP): organism physiology variant
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Hormone receptor domain | 0 | DIRECT |
| Spectrin repeat | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| Acyl-CoA dehydrogenase NM domain-like | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
| Carbohydrate phosphatase | 0 | DIRECT |
| Oxysterol-binding protein-like | 0 | DIRECT |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | DIRECT |
| WWE domain | 0 | DIRECT |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | DIRECT |
| Single hybrid motif | 0 | DIRECT |
| t-snare proteins | 0 | DIRECT |
| Cullin repeat-like | 0 | DIRECT |
| LDH C-terminal domain-like | 0 | DIRECT |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| Clc chloride channel | 0 | DIRECT |
| PHM/PNGase F | 0 | DIRECT |
| cAMP-binding domain-like | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| MFPT repeat-like | 0 | DIRECT |
| MgtE membrane domain-like | 0 | DIRECT |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| Nucleoporin domain | 0 | DIRECT |
| Band 7/SPFH domain | 0 | DIRECT |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | DIRECT |
| Annexin | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| Ribosomal L27 protein-like | 0 | DIRECT |
| Class II aaRS ABD-related | 0 | DIRECT |
| GYF domain | 0 | DIRECT |
| CBD9-like | 0 | DIRECT |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
| Tim10-like | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| PYP-like sensor domain (PAS domain) | 0 | DIRECT |
| TGS-like | 0 | DIRECT |
| Sec7 domain | 0 | DIRECT |
| Class I glutamine amidotransferase-like | 0 | DIRECT |
| LysM domain | 0 | DIRECT |
| HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
| GAS2 domain-like | 0 | DIRECT |
| Glycolipid transfer protein, GLTP | 0 | DIRECT |
| ThrRS/AlaRS common domain | 0 | DIRECT |
| Polo-box domain | 0 | DIRECT |
| Intermediate filament protein, coiled coil region | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| Restriction endonuclease-like | 0 | DIRECT |
| PUA domain-like | 0 | DIRECT |
| Cadherin-like | 0 | DIRECT |
| Invertebrate chitin-binding proteins | 0 | DIRECT |
| Purine and uridine phosphorylases | 0 | DIRECT |
| PurM C-terminal domain-like | 0 | DIRECT |
| TK C-terminal domain-like | 0 | DIRECT |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| Insulin-like | 0 | DIRECT |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | DIRECT |
| S-adenosylmethionine synthetase | 0 | DIRECT |
| Ribosomal protein S10 | 0 | DIRECT |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
| Complement control module/SCR domain | 0 | DIRECT |
| YWTD domain | 0 | DIRECT |
| Rap/Ran-GAP | 0 | DIRECT |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| R3H domain | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Surp module (SWAP domain) | 0 | DIRECT |
| GroEL-intermediate domain like | 0 | DIRECT |
| PEBP-like | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| Carbon-nitrogen hydrolase | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Actin-like ATPase domain | 0 | DIRECT |
| Integrin alpha N-terminal domain | 0 | DIRECT |
| SAICAR synthase-like | 0 | DIRECT |
| GroEL apical domain-like | 0 | DIRECT |
| eIF4e-like | 0 | DIRECT |
| Outer arm dynein light chain 1 | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| PEP carboxykinase-like | 0 | DIRECT |
| Cytochrome c | 0 | DIRECT |
| Skp1 dimerisation domain-like | 0 | DIRECT |
| Protease propeptides/inhibitors | 0 | DIRECT |
| Periplasmic binding protein-like II | 0 | DIRECT |
| Rudiment single hybrid motif | 0 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
| Nucleotidyltransferase | 0 | DIRECT |
| VPS9 domain | 0 | DIRECT |
| beta-lactamase/transpeptidase-like | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| PK beta-barrel domain-like | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| Carboxypeptidase regulatory domain-like | 0 | DIRECT |
| GroEL equatorial domain-like | 0 | DIRECT |
| FtsH protease domain-like | 0 | DIRECT |
| Citrate synthase | 0 | DIRECT |
| Creatinase/prolidase N-terminal domain | 0 | DIRECT |
| Second domain of FERM | 0 | DIRECT |
| PAP/OAS1 substrate-binding domain | 0 | DIRECT |
| Sec63 N-terminal domain-like | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
| SAND domain-like | 0 | DIRECT |
| Ribosomal protein L1 | 0 | DIRECT |
| ARID-like | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| Troponin coil-coiled subunits | 0 | DIRECT |
| Translational machinery components | 0 | DIRECT |
| PIN domain-like | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | DIRECT |
| Diaminopimelate epimerase-like | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| YbiA-like | 0 | DIRECT |
| Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
| Hedgehog/intein (Hint) domain | 0 | DIRECT |
| Zn-binding ribosomal proteins | 0 | DIRECT |
| PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | DIRECT |
| Chaperone J-domain | 0 | DIRECT |
| Hypothetical protein c14orf129, hspc210 | 0 | DIRECT |
| AN1-like Zinc finger | 0 | DIRECT |
| Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
| Tubulin C-terminal domain-like | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| Tubulin nucleotide-binding domain-like | 0 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0 | DIRECT |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | DIRECT |
| Nucleoside diphosphate kinase, NDK | 0 | DIRECT |
| HCP-like | 0 | DIRECT |
| Galactose oxidase, central domain | 0 | DIRECT |
| JAB1/MPN domain | 0 | DIRECT |
| Ribosomal protein L10-like | 0 | DIRECT |
| Arginase/deacetylase | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| Terpenoid synthases | 0 | DIRECT |
| CAD & PB1 domains | 0 | DIRECT |
| L30e-like | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| CRAL/TRIO N-terminal domain | 0 | DIRECT |
| Ribokinase-like | 0 | DIRECT |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
| Elafin-like | 0 | DIRECT |
| Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| SCP-like | 0 | DIRECT |
| Chitinase insertion domain | 0 | DIRECT |
| Cystatin/monellin | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| ENTH/VHS domain | 0 | DIRECT |
| Heme-dependent catalase-like | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| Tricorn protease domain 2 | 0 | DIRECT |
| Galactose mutarotase-like | 0 | DIRECT |
| Activating enzymes of the ubiquitin-like proteins | 0 | DIRECT |
| Thyroglobulin type-1 domain | 0 | DIRECT |
| HSP20-like chaperones | 0 | DIRECT |
| Cdc48 domain 2-like | 0 | DIRECT |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| dsRNA-binding domain-like | 0 | DIRECT |
| Heme-dependent peroxidases | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| RBP11-like subunits of RNA polymerase | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
| Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
| ADP-ribosylation | 0 | DIRECT |
| MOSC N-terminal domain-like | 0 | DIRECT |
| BEACH domain | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Small-conductance potassium channel | 0 | DIRECT |
| Type II DNA topoisomerase | 0 | DIRECT |
| alpha/beta knot | 0 | DIRECT |
| GAT-like domain | 0 | DIRECT |
| Aldolase | 0 | DIRECT |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | DIRECT |
| LEM domain | 0 | DIRECT |
| Kringle-like | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| lambda repressor-like DNA-binding domains | 0 | DIRECT |
| DEATH domain | 0 | DIRECT |
| ArfGap/RecO-like zinc finger | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
| Tubby C-terminal domain-like | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| Carbonic anhydrase | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
| Mitochondrial carrier | 0 | DIRECT |
| Fibrinogen C-terminal domain-like | 0 | DIRECT |
| Families 57/38 glycoside transferase middle domain | 0 | DIRECT |
| Ran binding protein zinc finger-like | 0 | DIRECT |
| Radical SAM enzymes | 0 | DIRECT |
| GroES-like | 0 | DIRECT |
| Chromo domain-like | 0 | DIRECT |
| Putative DNA-binding domain | 0 | DIRECT |
| Phoshotransferase/anion transport protein | 0 | DIRECT |
| PLC-like phosphodiesterases | 0 | DIRECT |
| Ribosomal proteins S24e, L23 and L15e | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| Subtilisin-like | 0 | DIRECT |
| Doublecortin (DC) | 0 | DIRECT |
| Pepsin inhibitor-3 | 0 | DIRECT |
| CO dehydrogenase ISP C-domain like | 0 | DIRECT |
| PABC (PABP) domain | 0 | DIRECT |
| SIS domain | 0 | DIRECT |
| 2Fe-2S ferredoxin-like | 0 | DIRECT |
| Profilin (actin-binding protein) | 0 | DIRECT |
| Pentein | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| Molybdenum cofactor-binding domain | 0 | DIRECT |
| Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
| DNA repair protein MutS, domain III | 0 | DIRECT |
| Aquaporin-like | 0 | DIRECT |
| Thiolase-like | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| L-aspartase-like | 0 | DIRECT |
| alpha-catenin/vinculin-like | 0 | DIRECT |
| Ferritin-like | 0 | DIRECT |
| PreATP-grasp domain | 0 | DIRECT |
| PGBD-like | 0 | DIRECT |
| ISP domain | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| PurM N-terminal domain-like | 0 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
| WGR domain-like | 0 | DIRECT |
| P-loop containing nucleoside triphosphate hydrolases | 0.0000001606 | DIRECT |
| PH domain-like | 0.00005362 | DIRECT |
| Histone-fold | 0.0001355 | DIRECT |
| Protein kinase-like (PK-like) | 0.004247 | INHERITED FROM: colchicine resistant || lipid synthesis increased || protein phosphorylation variant || egg laying response to food variant || alkaline pH chemotaxis variant || chemical response variant || metabolic pathway variant || mechanosensation variant || octanol chemotaxis defective || aldicarb response variant || metal response variant || protein phosphorylation reduced || protein expression variant || second messenger mediated signaling variant || positive chemotaxis variant || organism osmostic stress hypersensitive || drug induced gene expression variant || mid larval arrest || pathogen induced gene expression variant || conflicting sensory integration variant || protein subcellular localization variant || anoxia resistant || organism environmental stimulus response variant || kinase activity reduced || copper response variant |
| TPR-like | 0.01999 | INHERITED FROM: positive chemotaxis defective || ivermectin resistant || associative learning variant || ivermectin response variant || chemotaxis variant || antihelmintic response variant || light body touch resistant |
| Periplasmic binding protein-like I | 0.02009 | INHERITED FROM: aqueous positive chemotaxis variant || carbon dioxide avoidance variant || magnesium chemotaxis defective || benzaldehyde chemotaxis variant || alkaline pH chemotaxis variant || chemical response variant || mechanosensation variant || lithium chemotaxis defective || aqueous chemosensory response variant || AWC odorant chemotaxis variant || iodide chemotaxis defective || memory retention defective || chemotaxis variant || iodide chemotaxis variant || bromide chemotaxis variant || chemosensory response variant || second messenger mediated signaling variant || bromide chemotaxis defective || AWC odorant chemotaxis defective || diacetyl chemotaxis variant || organism environmental stimulus response variant |
| PapD-like | 0.02945 | INHERITED FROM: dauer lifespan variant || fat content variant || slow growth || larval growth variant || lipid metabolism variant || developmental growth variant || dauer lifespan extended || larval arrest || dauer metabolism variant |
| ARM repeat | 0.03947 | INHERITED FROM: organism hypersensitive ionizing radiation || gene expression variant || protein expression variant || organism metabolism processing variant || sick |
| SH2 domain | 0.04603 | INHERITED FROM: acetylcholinesterase inhibitor resistant || aldicarb resistant || protein expression variant || level of protein expression variant || protein expression reduced |
| "Winged helix" DNA-binding domain | 0.04806 | INHERITED FROM: protein aggregation variant || spontaneous mutation rate increased || paraquat hypersensitive || anesthetic response variant || life span variant || germline transgene silencing variant || protein expression increased || shortened life span || protein protein interaction variant || organism metabolism processing variant || protein aggregation induced behavior variant || chemical hypersensitive |
| PDZ domain-like | 0.05399 | INHERITED FROM: acetylcholinesterase inhibitor response variant || aldicarb response variant || protein expression variant |
| Homeodomain-like | 0.05676 | INHERITED FROM: carbon dioxide avoidance variant || inhibitor of serotonin uptake variant || imipramine resistant || adrenergic receptor antagonist response variant || ectopic expression transgene || protein degradation variant || growth rate variant || organism metabolism processing variant || level of transgene expression variant || carbon dioxide response variant || sexually dimorphic physiology variant || egg laying imipramine resistant |
| WD40 repeat-like | 0.06737 | INHERITED FROM: protein aggregation variant || late larval arrest || osmotic avoidance variant || antimicrobial gene expression variant || early larval arrest || protein protein interaction variant || organism metabolism processing variant || protein aggregation induced behavior variant |
| Nucleic acid-binding proteins | 0.06821 | INHERITED FROM: hypoxia resistant || mRNA surveillance defective || sick || nonsense mRNA accumulation || hydroxyurea response variant || hydroxyurea hypersensitive |
| Acetyl-CoA synthetase-like | 0.07031 | INHERITED FROM: lipid metabolism variant |
| Cyclin-like | 0.07776 | INHERITED FROM: protein phosphorylation variant || protein phosphorylation reduced |
| CCCH zinc finger | 0.08604 | INHERITED FROM: RNA metabolism variant || gene expression variant || transgene expression variant || ectopic expression transgene || mRNA expression ectopic |
| EGF/Laminin | 0.08699 | INHERITED FROM: negative chemotaxis variant || octanol chemotaxis defective || odorant negative chemotaxis defective || octanol chemotaxis variant |
| Translation proteins | 0.1054 | INHERITED FROM: protein aggregation variant || gene expression variant || mRNA levels increased || protein phosphorylation increased || transgene expression variant || protein protein interaction variant || organism metabolism processing variant || proteasome core activity variant || sick |
| Galactose-binding domain-like | 0.1093 | INHERITED FROM: protein interaction variant || protein aggregation variant || protein protein interaction variant |
| Nucleotide cyclase | 0.1288 | INHERITED FROM: magnesium chemotaxis defective || alkaline pH chemotaxis variant || cation positive chemotaxis defective || lithium chemotaxis defective || AWC odorant chemotaxis variant || iodide chemotaxis defective || osmotic avoidance variant || chemotaxis variant || iodide chemotaxis variant || anion positive chemotaxis defective || bromide chemotaxis variant || chemosensory response variant || second messenger mediated signaling variant || bromide chemotaxis defective || positive chemotaxis variant || cation positive chemotaxis variant || anion positive chemotaxis variant || AWC odorant chemotaxis defective || carbon dioxide response variant || diacetyl chemotaxis variant || organism environmental stimulus response variant |
| HLH, helix-loop-helix DNA-binding domain | 0.1288 | INHERITED FROM: fungal resistance increased || gene expression level reduced || ectopic expression transgene || aqueous positive chemotaxis defective || organism metabolism processing variant || lysine chemotaxis defective || pathogen resistance increased || RNA expression variant || hypoxia response variant |
| Acid proteases | 0.1291 | INHERITED FROM: protein interaction variant || protein aggregation variant || gene expression variant || transgene expression variant || osmotic integrity variant || hypoosmotic shock hypersensitive || protein protein interaction variant || transgene subcellular localization variant || organism metabolism processing variant |
| SMAD/FHA domain | 0.1291 | INHERITED FROM: aldicarb response variant |
| Calcium ATPase, transmembrane domain M | 0.1428 | INHERITED FROM: lipid composition variant || nicotine hypersensitive || organism environmental stimulus response variant |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1578 | INHERITED FROM: lipid composition variant || nicotine hypersensitive || organism environmental stimulus response variant |
| Regulator of G-protein signaling, RGS | 0.1578 | INHERITED FROM: negative chemotaxis variant || mechanosensation variant || chemotaxis variant |
| SH3-domain | 0.1682 | INHERITED FROM: aldicarb response variant || protein expression variant || protein expression reduced |
| E set domains | 0.1709 | INHERITED FROM: paraquat hypersensitive |
| Calcium ATPase, transduction domain A | 0.1748 | INHERITED FROM: nicotine hypersensitive || organism environmental stimulus response variant |
| Quinoprotein alcohol dehydrogenase-like | 0.1932 | INHERITED FROM: mRNA levels increased || drug response variant || protein degradation variant || mid larval arrest || L2 arrest || hypoxia response variant |
| Ankyrin repeat | 0.2048 | INHERITED FROM: mechanosensation variant || octanol chemotaxis defective || organism heat response variant || chemotaxis variant || chemosensory response variant || odorant negative chemotaxis defective || octanol chemotaxis variant |
| Multidrug efflux transporter AcrB transmembrane domain | 0.2081 | INHERITED FROM: embryo osmotic integrity defective early emb || positive chemotaxis defective || chemotaxis variant || egg integrity defective early emb || odorant chemosensory response variant || odorant positive chemotaxis defective |
| DBL homology domain (DH-domain) | 0.2129 | INHERITED FROM: bacterially unswollen || aldicarb response variant || organism pathogen response variant || pathogen resistance increased || organism environmental stimulus response variant |
| HMG-box | 0.235 | INHERITED FROM: transgene expression variant || maintenance of gene silencing variant |
| ClpP/crotonase | 0.235 | INHERITED FROM: fat content variant || lipid metabolism variant || level of transgene expression variant |
| Cytochrome P450 | 0.2364 | INHERITED FROM: metal response variant || cadmium response variant |
| (Trans)glycosidases | 0.2364 | INHERITED FROM: pathogen susceptibility increased || pathogen load variant |
| POZ domain | 0.2767 | INHERITED FROM: resistant to protein aggregation induced paralysis || early larval arrest || L1 arrest || protein aggregation induced behavior variant || chemical hypersensitive |
| Bromodomain | 0.2854 | INHERITED FROM: anesthetic resistant || acute functional tolerance to alcohol defective || anesthetic response variant || ethanol resistant || organism UV response variant || drug adaptation variant || sick || organism UV hypersensitive |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.2854 | INHERITED FROM: fat content variant || lipid metabolism variant |
| RNA-binding domain, RBD | 0.2867 | INHERITED FROM: RNA processing variant || mRNA export variant || no induction of antimicrobial peptide expression after infection || antimicrobial gene expression variant || alternative splicing variant || organism metabolism processing variant || innate immune response variant || sick || starvation induced apoptosis variant || RNA expression variant || maintenance of gene silencing variant |
| Cysteine proteinases | 0.2916 | INHERITED FROM: protein interaction variant || pattern of transgene expression variant || paraquat hypersensitive || osmotic integrity variant || hypoosmotic shock hypersensitive || protein protein interaction variant || organism metabolism processing variant |
| RNI-like | 0.3025 | INHERITED FROM: resistant to protein aggregation induced paralysis |
| SNARE-like | 0.3135 | INHERITED FROM: acetylcholinesterase inhibitor resistant || pattern of transgene expression variant || gene expression variant || transgene expression variant || aldicarb resistant || transgene subcellular localization variant || protein metabolism variant || organism metabolism processing variant || sick |
| ABC transporter transmembrane region | 0.3161 | INHERITED FROM: metal response variant || cadmium response variant || colchicine hypersensitive || RNAi response variant || organism environmental stimulus response variant |
| Lipocalins | 0.3253 | INHERITED FROM: fat content variant || paraquat hypersensitive || fat content increased || lipid metabolism variant |
| Translation proteins SH3-like domain | 0.3798 | INHERITED FROM: protein aggregation variant || gene expression variant || transgene expression variant || early larval arrest || organism metabolism processing variant |
| Cation efflux protein transmembrane domain-like | 0.3798 | INHERITED FROM: manganese toxicity resistant || cadmium hypersensitive || manganese response variant || metal response variant |
| Nicotinic receptor ligand binding domain-like | 0.3921 | INHERITED FROM: chemical response variant || nicotine resistant || mechanosensation variant || aqueous chemosensory response variant || cholinergic agonist resistant || selenium response variant || DMPP response variant || sodium chloride chemotaxis variant || drug response variant || hypoosmotic shock hypersensitive || slowing response on food variant || antihelmintic response variant || organism environmental stimulus response variant |
| Ubiquitin-like | 0.4089 | INHERITED FROM: protein interaction variant || protein aggregation variant || heteroplasmy || protein protein interaction variant || organism metabolism processing variant |
| Cysteine-rich domain | 0.423 | INHERITED FROM: bacterially unswollen || aldicarb response variant || odorant positive chemotaxis variant || antimicrobial gene expression variant || positive chemotaxis variant || drug induced gene expression variant || organism metabolism processing variant || organism pathogen response variant || odorant chemosensory response variant || protein subcellular localization variant |
| FKBP-like | 0.429 | INHERITED FROM: protein interaction variant || protein aggregation variant || pattern of transgene expression variant || protein protein interaction variant || transgene subcellular localization variant |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.4299 | INHERITED FROM: chemical response variant || nicotine resistant || mechanosensation variant || aqueous chemosensory response variant || cholinergic agonist resistant || selenium response variant || DMPP response variant || sodium chloride chemotaxis variant || drug response variant || hypoosmotic shock hypersensitive || positive chemotaxis variant || slowing response on food variant || antihelmintic response variant || organism environmental stimulus response variant |
| Class II aaRS and biotin synthetases | 0.4882 | INHERITED FROM: hypoxia resistant || gene expression variant || oxygen response variant || transgene expression variant || organism metabolism processing variant || organism environmental stimulus response variant || hypoxia response variant |
| DHS-like NAD/FAD-binding domain | 0.5016 | INHERITED FROM: protein acetylation variant || protein modification variant |
| PRTase-like | 0.5016 | INHERITED FROM: Fluorouracil resistant || drug resistant |
| Hect, E3 ligase catalytic domain | 0.5016 | INHERITED FROM: protein interaction variant || protein aggregation variant || pattern of transgene expression variant || gene expression variant || transgene expression variant || protein protein interaction variant || transgene subcellular localization variant || organism metabolism processing variant || protein aggregation induced behavior variant |
| Myosin rod fragments | 0.5016 | INHERITED FROM: drug resistant |
| BRCT domain | 0.5231 | INHERITED FROM: organism ionizing radiation response variant |
| FYVE/PHD zinc finger | 0.5422 | INHERITED FROM: organism UV response variant || protein modification variant || ectopic expression transgene || protein methylation variant || organism UV hypersensitive |
| Ribosomal protein S5 domain 2-like | 0.5456 | INHERITED FROM: early larval arrest |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.5511 | INHERITED FROM: pattern protein expression variant |
| Calpain large subunit, middle domain (domain III) | 0.5511 | INHERITED FROM: metabolic pathway variant || protein degradation variant || protein metabolism variant |
| Riboflavin synthase domain-like | 0.5511 | INHERITED FROM: pattern protein expression variant |
| Sm-like ribonucleoproteins | 0.5548 | INHERITED FROM: pattern of transgene expression variant || gene expression variant || organism heat response variant || transgene expression variant || life span variant || protein subcellular localization variant || sick || unfolded protein response variant |
| WW domain | 0.5548 | INHERITED FROM: maintenance of gene silencing variant |
| FAD-linked reductases, C-terminal domain | 0.5548 | INHERITED FROM: life span variant |
| Cystine-knot cytokines | 0.5548 | INHERITED FROM: levamisole response variant || nicotine response variant |
| Voltage-gated potassium channels | 0.559 | INHERITED FROM: adrenergic receptor antagonist response variant || positive chemotaxis defective || mechanosensation variant || protein degradation variant || protein metabolism variant || growth rate variant || serotonin response variant || serotonin resistant |
| Nucleotidylyl transferase | 0.579 | INHERITED FROM: hypoxia resistant || oxygen response variant || transgene expression increased || paraquat resistant || organism metabolism processing variant || organism environmental stimulus response variant || hypoxia response variant |
| FAD/NAD(P)-binding domain | 0.5823 | INHERITED FROM: ATP levels reduced || life span variant || pesticide response variant || ATP levels variant |
| SET domain | 0.5911 | INHERITED FROM: ectopic expression antibody || dosage compensation variant || spontaneous mutation rate increased || metabolic pathway variant || life span variant || protein modification variant || shortened life span || protein expression variant || protein metabolism variant || somatic transgene silencing variant || protein methylation variant || RNAi response variant || histone methylation variant || maintenance of gene silencing variant |
| Seven-hairpin glycosidases | 0.6011 | INHERITED FROM: protein aggregation variant || extended life span || protein protein interaction variant |
| SAM/Pointed domain | 0.604 | INHERITED FROM: aldicarb response variant |
| UBC-like | 0.6153 | INHERITED FROM: protein interaction variant || protein aggregation variant || pattern of transgene expression variant || late larval arrest || protein protein interaction variant || transgene subcellular localization variant || organism metabolism processing variant || sick |
| Multidrug resistance efflux transporter EmrE | 0.6221 | INHERITED FROM: bacterially unswollen || pathogen resistance increased |
| HAD-like | 0.6294 | INHERITED FROM: nicotine hypersensitive |
| Osmotin, thaumatin-like protein | 0.658 | INHERITED FROM: cadmium hypersensitive || metal response variant || cadmium response variant |
| KA1-like | 0.658 | INHERITED FROM: RNA expression variant |
| Nucleotide-binding domain | 0.658 | INHERITED FROM: extended life span |
| MFS general substrate transporter | 0.6887 | INHERITED FROM: organism high sodium chloride hypersensitive |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.6891 | INHERITED FROM: chemical response variant || metabolic pathway variant || aging variant || antimicrobial gene expression variant || protein expression variant || drug induced gene expression variant || growth rate variant || nose touch variant || protein subcellular localization variant || RNAi response variant || organism environmental stimulus response variant || drug resistant |
| GST C-terminal domain-like | 0.712 | INHERITED FROM: organism stress response variant || cadmium hypersensitive || organism heat hypersensitive || organism electrophilic stress hypersensitive || metal response variant || enzyme activity reduced || organism environmental stimulus response variant || enzyme activity variant |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.7169 | INHERITED FROM: dauer resistance to harsh conditions variant || fat content increased || gene expression level high || gene expression level reduced || transgene expression reduced || level of transgene expression variant || SDS sensitive dauer |
| 4Fe-4S ferredoxins | 0.7196 | INHERITED FROM: life span variant || transgene expression increased |
| S15/NS1 RNA-binding domain | 0.7196 | INHERITED FROM: transgene expression increased |
| Frizzled cysteine-rich domain | 0.7196 | INHERITED FROM: transgene expression reduced || antibody staining variant |
| Ribonuclease H-like | 0.7509 | INHERITED FROM: siRNA expression variant || 21U RNA expression variant || RNAi enhanced || somatic transgene silencing variant || RNAi response variant || RNA expression variant || maintenance of gene silencing variant |
| PAZ domain | 0.7644 | INHERITED FROM: mRNA levels increased || siRNA expression variant || 21U RNA expression variant || RNAi enhanced || somatic transgene silencing variant || RNAi response variant || RNA expression variant || maintenance of gene silencing variant |
| MIT domain | 0.7863 | INHERITED FROM: protein interaction variant || protein aggregation variant || protein protein interaction variant |
| ADC-like | 0.7863 | INHERITED FROM: protein interaction variant || protein aggregation variant || metabolic pathway variant || transgene expression reduced || protein protein interaction variant || protein metabolism variant |
| alpha/beta-Hydrolases | 0.82 | INHERITED FROM: acetylcholinesterase activity variant || acetylcholinesterase reduced |
| Fibronectin type III | 0.8262 | INHERITED FROM: metabolic pathway variant |
| Clavaminate synthase-like | 0.8607 | INHERITED FROM: life span variant || organism temperature response variant || protein methylation variant || histone methylation variant |
| EF-hand | 0.8649 | INHERITED FROM: protein interaction variant || protein aggregation variant |
| Leucine zipper domain | 0.8735 | INHERITED FROM: mRNA levels reduced || mRNA expression variant || transgene expression reduced || pathogen susceptibility increased || level of transgene expression variant || pore forming toxin response variant |
| GTPase activation domain, GAP | 0.8822 | INHERITED FROM: protein expression variant |
| UBA-like | 0.8849 | INHERITED FROM: protein aggregation variant || protein protein interaction variant |
| DNA/RNA polymerases | 0.9468 | INHERITED FROM: DNA repair variant || DNA metabolism variant |
| p53-like transcription factors | 0.9517 | INHERITED FROM: gene expression level reduced || ectopic expression transgene |
| Ribonuclease PH domain 2-like | 0.9623 | INHERITED FROM: early larval arrest |
| Thioredoxin-like | 0.9729 | INHERITED FROM: organism stress response variant || cadmium hypersensitive || organism heat hypersensitive || organism electrophilic stress hypersensitive || enzyme activity reduced || paraquat response variant || organism environmental stimulus response variant || enzyme activity variant |
| Immunoglobulin | 0.973 | INHERITED FROM: aldicarb response variant || protein degradation variant || growth rate variant |
| Nuclear receptor ligand-binding domain | 0.9837 | INHERITED FROM: dauer resistance to harsh conditions variant || fat content increased || gene expression level high || gene expression level reduced || lipid metabolism variant || transgene expression reduced || level of transgene expression variant || SDS sensitive dauer |
| Eukaryotic type KH-domain (KH-domain type I) | 1 | INHERITED FROM: RNA expression variant |
| beta-beta-alpha zinc fingers | 1 | INHERITED FROM: inhibitor of serotonin uptake variant || imipramine resistant || organism metabolism processing variant || egg laying imipramine resistant |
| Cyclophilin-like | 1 | INHERITED FROM: protein interaction variant || protein aggregation variant || pattern of transgene expression variant || gene expression variant || transgene expression variant || protein protein interaction variant || transgene subcellular localization variant |
| Saposin | 1 | INHERITED FROM: increased pathogen survival || transgene expression reduced || level of transgene expression variant || pathogen load variant |
| Bet v1-like | 1 | INHERITED FROM: growth rate variant |
| CoA-dependent acyltransferases | 1 | INHERITED FROM: lipid metabolism variant |
| Ligand-binding domain in the NO signalling and Golgi transport | 1 | INHERITED FROM: carbon dioxide avoidance variant || carbon dioxide response variant |
| RING/U-box | 1 | INHERITED FROM: protein interaction variant || protein aggregation variant || pattern of transgene expression variant || gene expression variant || transgene expression variant || protein protein interaction variant || transgene subcellular localization variant || organism metabolism processing variant |
| Family A G protein-coupled receptor-like | 1 | INHERITED FROM: serotonin induced fat reduction variant || male tail curling serotonin variant || locomotion rate serotonin variant || serotonin induced pumping variant |
| B-box zinc-binding domain | 1 | INHERITED FROM: protein interaction variant || protein aggregation variant || gene expression variant || transgene expression variant || protein protein interaction variant || transgene subcellular localization variant || organism metabolism processing variant |
| F-box domain | 1 | INHERITED FROM: resistant to protein aggregation induced paralysis |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | Direct |
| Hormone receptor domain | 0 | Direct |
| Spectrin repeat | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| Acyl-CoA dehydrogenase NM domain-like | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Bacterial exopeptidase dimerisation domain | 0 | Direct |
| Carbohydrate phosphatase | 0 | Direct |
| Oxysterol-binding protein-like | 0 | Direct |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | Direct |
| WWE domain | 0 | Direct |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | Direct |
| Single hybrid motif | 0 | Direct |
| t-snare proteins | 0 | Direct |
| Cullin repeat-like | 0 | Direct |
| LDH C-terminal domain-like | 0 | Direct |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| Clc chloride channel | 0 | Direct |
| PHM/PNGase F | 0 | Direct |
| cAMP-binding domain-like | 0 | Direct |
| SPOC domain-like | 0 | Direct |
| MFPT repeat-like | 0 | Direct |
| MgtE membrane domain-like | 0 | Direct |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
| Nop domain | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| Nucleoporin domain | 0 | Direct |
| Band 7/SPFH domain | 0 | Direct |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | Direct |
| Annexin | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| Ribosomal L27 protein-like | 0 | Direct |
| Class II aaRS ABD-related | 0 | Direct |
| GYF domain | 0 | Direct |
| CBD9-like | 0 | Direct |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
| Tim10-like | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| PYP-like sensor domain (PAS domain) | 0 | Direct |
| TGS-like | 0 | Direct |
| Sec7 domain | 0 | Direct |
| Class I glutamine amidotransferase-like | 0 | Direct |
| LysM domain | 0 | Direct |
| HSP40/DnaJ peptide-binding domain | 0 | Direct |
| GAS2 domain-like | 0 | Direct |
| Glycolipid transfer protein, GLTP | 0 | Direct |
| ThrRS/AlaRS common domain | 0 | Direct |
| Polo-box domain | 0 | Direct |
| Intermediate filament protein, coiled coil region | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| Restriction endonuclease-like | 0 | Direct |
| PUA domain-like | 0 | Direct |
| Cadherin-like | 0 | Direct |
| Invertebrate chitin-binding proteins | 0 | Direct |
| Purine and uridine phosphorylases | 0 | Direct |
| PurM C-terminal domain-like | 0 | Direct |
| TK C-terminal domain-like | 0 | Direct |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| Insulin-like | 0 | Direct |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | Direct |
| S-adenosylmethionine synthetase | 0 | Direct |
| Ribosomal protein S10 | 0 | Direct |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
| Complement control module/SCR domain | 0 | Direct |
| YWTD domain | 0 | Direct |
| Rap/Ran-GAP | 0 | Direct |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
| Proton glutamate symport protein | 0 | Direct |
| R3H domain | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Surp module (SWAP domain) | 0 | Direct |
| GroEL-intermediate domain like | 0 | Direct |
| PEBP-like | 0 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| Carbon-nitrogen hydrolase | 0 | Direct |
| ALDH-like | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Actin-like ATPase domain | 0 | Direct |
| Integrin alpha N-terminal domain | 0 | Direct |
| SAICAR synthase-like | 0 | Direct |
| GroEL apical domain-like | 0 | Direct |
| eIF4e-like | 0 | Direct |
| Outer arm dynein light chain 1 | 0 | Direct |
| FF domain | 0 | Direct |
| PEP carboxykinase-like | 0 | Direct |
| Cytochrome c | 0 | Direct |
| Skp1 dimerisation domain-like | 0 | Direct |
| Protease propeptides/inhibitors | 0 | Direct |
| Periplasmic binding protein-like II | 0 | Direct |
| Rudiment single hybrid motif | 0 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
| Nucleotidyltransferase | 0 | Direct |
| VPS9 domain | 0 | Direct |
| beta-lactamase/transpeptidase-like | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| PK beta-barrel domain-like | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| Carboxypeptidase regulatory domain-like | 0 | Direct |
| GroEL equatorial domain-like | 0 | Direct |
| FtsH protease domain-like | 0 | Direct |
| Citrate synthase | 0 | Direct |
| Creatinase/prolidase N-terminal domain | 0 | Direct |
| Second domain of FERM | 0 | Direct |
| PAP/OAS1 substrate-binding domain | 0 | Direct |
| Sec63 N-terminal domain-like | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
| SAND domain-like | 0 | Direct |
| Ribosomal protein L1 | 0 | Direct |
| ARID-like | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| Troponin coil-coiled subunits | 0 | Direct |
| Translational machinery components | 0 | Direct |
| PIN domain-like | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | Direct |
| Diaminopimelate epimerase-like | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| YbiA-like | 0 | Direct |
| Blood coagulation inhibitor (disintegrin) | 0 | Direct |
| Hedgehog/intein (Hint) domain | 0 | Direct |
| Zn-binding ribosomal proteins | 0 | Direct |
| PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | Direct |
| Chaperone J-domain | 0 | Direct |
| Hypothetical protein c14orf129, hspc210 | 0 | Direct |
| AN1-like Zinc finger | 0 | Direct |
| Composite domain of metallo-dependent hydrolases | 0 | Direct |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
| Tubulin C-terminal domain-like | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| Tubulin nucleotide-binding domain-like | 0 | Direct |
| Transducin (alpha subunit), insertion domain | 0 | Direct |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | Direct |
| Nucleoside diphosphate kinase, NDK | 0 | Direct |
| HCP-like | 0 | Direct |
| Galactose oxidase, central domain | 0 | Direct |
| JAB1/MPN domain | 0 | Direct |
| Ribosomal protein L10-like | 0 | Direct |
| Arginase/deacetylase | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| Terpenoid synthases | 0 | Direct |
| CAD & PB1 domains | 0 | Direct |
| L30e-like | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| CRAL/TRIO N-terminal domain | 0 | Direct |
| Ribokinase-like | 0 | Direct |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
| Elafin-like | 0 | Direct |
| Cation efflux protein cytoplasmic domain-like | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
| Integrin domains | 0 | Direct |
| SCP-like | 0 | Direct |
| Chitinase insertion domain | 0 | Direct |
| Cystatin/monellin | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| ENTH/VHS domain | 0 | Direct |
| Heme-dependent catalase-like | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| Tricorn protease domain 2 | 0 | Direct |
| Galactose mutarotase-like | 0 | Direct |
| Activating enzymes of the ubiquitin-like proteins | 0 | Direct |
| Thyroglobulin type-1 domain | 0 | Direct |
| HSP20-like chaperones | 0 | Direct |
| Cdc48 domain 2-like | 0 | Direct |
| Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
| dsRNA-binding domain-like | 0 | Direct |
| Heme-dependent peroxidases | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| RBP11-like subunits of RNA polymerase | 0 | Direct |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
| Glutathione synthetase ATP-binding domain-like | 0 | Direct |
| ADP-ribosylation | 0 | Direct |
| MOSC N-terminal domain-like | 0 | Direct |
| BEACH domain | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Small-conductance potassium channel | 0 | Direct |
| Type II DNA topoisomerase | 0 | Direct |
| alpha/beta knot | 0 | Direct |
| GAT-like domain | 0 | Direct |
| Aldolase | 0 | Direct |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | Direct |
| LEM domain | 0 | Direct |
| Kringle-like | 0 | Direct |
| MIR domain | 0 | Direct |
| lambda repressor-like DNA-binding domains | 0 | Direct |
| DEATH domain | 0 | Direct |
| ArfGap/RecO-like zinc finger | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
| Tubby C-terminal domain-like | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| Carbonic anhydrase | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
| Mitochondrial carrier | 0 | Direct |
| Fibrinogen C-terminal domain-like | 0 | Direct |
| Families 57/38 glycoside transferase middle domain | 0 | Direct |
| Ran binding protein zinc finger-like | 0 | Direct |
| Radical SAM enzymes | 0 | Direct |
| GroES-like | 0 | Direct |
| Chromo domain-like | 0 | Direct |
| Putative DNA-binding domain | 0 | Direct |
| Phoshotransferase/anion transport protein | 0 | Direct |
| PLC-like phosphodiesterases | 0 | Direct |
| Ribosomal proteins S24e, L23 and L15e | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| Subtilisin-like | 0 | Direct |
| Doublecortin (DC) | 0 | Direct |
| Pepsin inhibitor-3 | 0 | Direct |
| CO dehydrogenase ISP C-domain like | 0 | Direct |
| PABC (PABP) domain | 0 | Direct |
| SIS domain | 0 | Direct |
| 2Fe-2S ferredoxin-like | 0 | Direct |
| Profilin (actin-binding protein) | 0 | Direct |
| Pentein | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| Molybdenum cofactor-binding domain | 0 | Direct |
| Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
| DNA repair protein MutS, domain III | 0 | Direct |
| Aquaporin-like | 0 | Direct |
| Thiolase-like | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| L-aspartase-like | 0 | Direct |
| alpha-catenin/vinculin-like | 0 | Direct |
| Ferritin-like | 0 | Direct |
| PreATP-grasp domain | 0 | Direct |
| PGBD-like | 0 | Direct |
| ISP domain | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| PurM N-terminal domain-like | 0 | Direct |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
| WGR domain-like | 0 | Direct |
| P-loop containing nucleoside triphosphate hydrolases | 0.0000001606 | Direct |
| PH domain-like | 0.00005362 | Direct |
| Histone-fold | 0.0001355 | Direct |
| Protein kinase-like (PK-like) | 0.004247 | Inherited |
| TPR-like | 0.01999 | Inherited |
| Periplasmic binding protein-like I | 0.02009 | Inherited |
| PapD-like | 0.02945 | Inherited |
| ARM repeat | 0.03947 | Inherited |
| SH2 domain | 0.04603 | Inherited |
| "Winged helix" DNA-binding domain | 0.04806 | Inherited |
| PDZ domain-like | 0.05399 | Inherited |
| Homeodomain-like | 0.05676 | Inherited |
| WD40 repeat-like | 0.06737 | Inherited |
| Nucleic acid-binding proteins | 0.06821 | Inherited |
| Acetyl-CoA synthetase-like | 0.07031 | Inherited |
| Cyclin-like | 0.07776 | Inherited |
| CCCH zinc finger | 0.08604 | Inherited |
| EGF/Laminin | 0.08699 | Inherited |
| Translation proteins | 0.1054 | Inherited |
| Galactose-binding domain-like | 0.1093 | Inherited |
| Nucleotide cyclase | 0.1288 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.1288 | Inherited |
| Acid proteases | 0.1291 | Inherited |
| SMAD/FHA domain | 0.1291 | Inherited |
| Calcium ATPase, transmembrane domain M | 0.1428 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1578 | Inherited |
| Regulator of G-protein signaling, RGS | 0.1578 | Inherited |
| SH3-domain | 0.1682 | Inherited |
| E set domains | 0.1709 | Inherited |
| Calcium ATPase, transduction domain A | 0.1748 | Inherited |
| Quinoprotein alcohol dehydrogenase-like | 0.1932 | Inherited |
| Ankyrin repeat | 0.2048 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.2081 | Inherited |
| DBL homology domain (DH-domain) | 0.2129 | Inherited |
| HMG-box | 0.235 | Inherited |
| ClpP/crotonase | 0.235 | Inherited |
| Cytochrome P450 | 0.2364 | Inherited |
| (Trans)glycosidases | 0.2364 | Inherited |
| POZ domain | 0.2767 | Inherited |
| Bromodomain | 0.2854 | Inherited |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.2854 | Inherited |
| RNA-binding domain, RBD | 0.2867 | Inherited |
| Cysteine proteinases | 0.2916 | Inherited |
| RNI-like | 0.3025 | Inherited |
| SNARE-like | 0.3135 | Inherited |
| ABC transporter transmembrane region | 0.3161 | Inherited |
| Lipocalins | 0.3253 | Inherited |
| Translation proteins SH3-like domain | 0.3798 | Inherited |
| Cation efflux protein transmembrane domain-like | 0.3798 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.3921 | Inherited |
| Ubiquitin-like | 0.4089 | Inherited |
| Cysteine-rich domain | 0.423 | Inherited |
| FKBP-like | 0.429 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.4299 | Inherited |
| Class II aaRS and biotin synthetases | 0.4882 | Inherited |
| DHS-like NAD/FAD-binding domain | 0.5016 | Inherited |
| PRTase-like | 0.5016 | Inherited |
| Hect, E3 ligase catalytic domain | 0.5016 | Inherited |
| Myosin rod fragments | 0.5016 | Inherited |
| BRCT domain | 0.5231 | Inherited |
| FYVE/PHD zinc finger | 0.5422 | Inherited |
| Ribosomal protein S5 domain 2-like | 0.5456 | Inherited |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.5511 | Inherited |
| Calpain large subunit, middle domain (domain III) | 0.5511 | Inherited |
| Riboflavin synthase domain-like | 0.5511 | Inherited |
| Sm-like ribonucleoproteins | 0.5548 | Inherited |
| WW domain | 0.5548 | Inherited |
| FAD-linked reductases, C-terminal domain | 0.5548 | Inherited |
| Cystine-knot cytokines | 0.5548 | Inherited |
| Voltage-gated potassium channels | 0.559 | Inherited |
| Nucleotidylyl transferase | 0.579 | Inherited |
| FAD/NAD(P)-binding domain | 0.5823 | Inherited |
| SET domain | 0.5911 | Inherited |
| Seven-hairpin glycosidases | 0.6011 | Inherited |
| SAM/Pointed domain | 0.604 | Inherited |
| UBC-like | 0.6153 | Inherited |
| Multidrug resistance efflux transporter EmrE | 0.6221 | Inherited |
| HAD-like | 0.6294 | Inherited |
| Osmotin, thaumatin-like protein | 0.658 | Inherited |
| KA1-like | 0.658 | Inherited |
| Nucleotide-binding domain | 0.658 | Inherited |
| MFS general substrate transporter | 0.6887 | Inherited |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.6891 | Inherited |
| GST C-terminal domain-like | 0.712 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.7169 | Inherited |
| 4Fe-4S ferredoxins | 0.7196 | Inherited |
| S15/NS1 RNA-binding domain | 0.7196 | Inherited |
| Frizzled cysteine-rich domain | 0.7196 | Inherited |
| Ribonuclease H-like | 0.7509 | Inherited |
| PAZ domain | 0.7644 | Inherited |
| MIT domain | 0.7863 | Inherited |
| ADC-like | 0.7863 | Inherited |
| alpha/beta-Hydrolases | 0.82 | Inherited |
| Fibronectin type III | 0.8262 | Inherited |
| Clavaminate synthase-like | 0.8607 | Inherited |
| EF-hand | 0.8649 | Inherited |
| Leucine zipper domain | 0.8735 | Inherited |
| GTPase activation domain, GAP | 0.8822 | Inherited |
| UBA-like | 0.8849 | Inherited |
| DNA/RNA polymerases | 0.9468 | Inherited |
| p53-like transcription factors | 0.9517 | Inherited |
| Ribonuclease PH domain 2-like | 0.9623 | Inherited |
| Thioredoxin-like | 0.9729 | Inherited |
| Immunoglobulin | 0.973 | Inherited |
| Nuclear receptor ligand-binding domain | 0.9837 | Inherited |
| Eukaryotic type KH-domain (KH-domain type I) | 1 | Inherited |
| beta-beta-alpha zinc fingers | 1 | Inherited |
| Cyclophilin-like | 1 | Inherited |
| Saposin | 1 | Inherited |
| Bet v1-like | 1 | Inherited |
| CoA-dependent acyltransferases | 1 | Inherited |
| Ligand-binding domain in the NO signalling and Golgi transport | 1 | Inherited |
| RING/U-box | 1 | Inherited |
| Family A G protein-coupled receptor-like | 1 | Inherited |
| B-box zinc-binding domain | 1 | Inherited |
| F-box domain | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Clathrin coat assembly domain | 0 | DIRECT |
| Oxysterol-binding protein | 0 | DIRECT |
| Peptidylglycine alpha-hydroxylating monooxygenase, PHM | 0 | DIRECT |
| POU-specific domain | 0 | DIRECT |
| Translation initiation factor eIF4e | 0 | DIRECT |
| Cullin repeat | 0 | DIRECT |
| Chaperone J-domain | 0 | DIRECT |
| Hydantoinase (dihydropyrimidinase) | 0 | DIRECT |
| YihX-like | 0 | DIRECT |
| WWE domain | 0 | DIRECT |
| AAT-like | 0 | DIRECT |
| Methionine aminopeptidase, insert domain | 0 | DIRECT |
| Trunk domain of Sec23/24 | 0 | DIRECT |
| Chitinase insertion domain | 0 | DIRECT |
| Small-conductance potassium channel | 0 | DIRECT |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
| PurM C-terminal domain-like | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | DIRECT |
| Profilin (actin-binding protein) | 0 | DIRECT |
| Acyl-carrier protein (ACP) | 0 | DIRECT |
| Acireductone dioxygenase | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| 28-residue LRR | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| Doublecortin (DC) | 0 | DIRECT |
| RecA protein-like (ATPase-domain) | 0 | DIRECT |
| Alcohol dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| Translational machinery components | 0 | DIRECT |
| cAMP-binding domain | 0 | DIRECT |
| GAS2 domain | 0 | DIRECT |
| COMT-like | 0 | DIRECT |
| SWIRM domain | 0 | DIRECT |
| PDEase | 0 | DIRECT |
| Troponin I | 0 | DIRECT |
| Acyl-CoA thioesterase | 0 | DIRECT |
| MFPT repeat | 0 | DIRECT |
| Arylsulfatase | 0 | DIRECT |
| BEACH domain | 0 | DIRECT |
| Glycosyl transferases group 1 | 0 | DIRECT |
| BC C-terminal domain-like | 0 | DIRECT |
| LysM domain | 0 | DIRECT |
| DPP6 catalytic domain-like | 0 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0 | DIRECT |
| HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
| Brix domain | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| Protein prenyltransferases | 0 | DIRECT |
| BC N-terminal domain-like | 0 | DIRECT |
| acyl-CoA oxidase C-terminal domains | 0 | DIRECT |
| Ribosomal protein L1 | 0 | DIRECT |
| VHS domain | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Sir2 family of transcriptional regulators | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
| Subtilases | 0 | DIRECT |
| Poly(ADP-ribose) polymerase, C-terminal domain | 0 | DIRECT |
| Poly(A) polymerase, PAP, C-terminal domain | 0 | DIRECT |
| Acylamino-acid-releasing enzyme, C-terminal donain | 0 | DIRECT |
| Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
| Third domain of FERM | 0 | DIRECT |
| Thyroglobulin type-1 domain | 0 | DIRECT |
| Double-stranded RNA-binding domain (dsRBD) | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Sterol carrier protein, SCP | 0 | DIRECT |
| Thiolase-related | 0 | DIRECT |
| Cell cycle control phosphatase, catalytic domain | 0 | DIRECT |
| Quinoprotein alcohol dehydrogenase-like | 0 | DIRECT |
| Inositol polyphosphate kinase (IPK) | 0 | DIRECT |
| GAPDH-like | 0 | DIRECT |
| PaaI/YdiI-like | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| Hsp90 middle domain | 0 | DIRECT |
| Ribosomal protein L18 and S11 | 0 | DIRECT |
| t-snare proteins | 0 | DIRECT |
| Phosphatidylethanolamine binding protein | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | DIRECT |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| Choline kinase | 0 | DIRECT |
| HEAT repeat | 0 | DIRECT |
| alpha-mannosidase, domain 2 | 0 | DIRECT |
| Laminin G-like module | 0 | DIRECT |
| DEP domain | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| Ribokinase-like | 0 | DIRECT |
| BAR domain | 0 | DIRECT |
| Adenosine/AMP deaminase | 0 | DIRECT |
| D-aminoacid oxidase, N-terminal domain | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| a tRNA synthase domain | 0 | DIRECT |
| Glycogenin | 0 | DIRECT |
| RNA editing terminal uridyl transferase 2, RET2, domain 2 | 0 | DIRECT |
| Ngr ectodomain-like | 0 | DIRECT |
| Matrix metalloproteases, catalytic domain | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain | 0 | DIRECT |
| Biotinyl/lipoyl-carrier proteins and domains | 0 | DIRECT |
| Insulin-like | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | DIRECT |
| L-aminoacid/polyamine oxidase | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0 | DIRECT |
| Reprolysin-like | 0 | DIRECT |
| NHL repeat | 0 | DIRECT |
| Hedgehog C-terminal (Hog) autoprocessing domain | 0 | DIRECT |
| Second domain of FERM | 0 | DIRECT |
| Hydantoinase (dihydropyrimidinase), catalytic domain | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Formate/glycerate dehydrogenases, NAD-domain | 0 | DIRECT |
| Alcohol dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
| Sec7 domain | 0 | DIRECT |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0 | DIRECT |
| IF2B-like | 0 | DIRECT |
| FHA domain | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| AN1-like Zinc finger | 0 | DIRECT |
| Calpain large subunit, catalytic domain (domain II) | 0 | DIRECT |
| Citrate synthase | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| Calcium ATPase, transmembrane domain M | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| RhoGDI-like | 0 | DIRECT |
| Regulator of chromosome condensation RCC1 | 0 | DIRECT |
| Internalin LRR domain | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | DIRECT |
| Cdc48 domain 2-like | 0 | DIRECT |
| Ribonucleotide reductase-like | 0 | DIRECT |
| HSP20 | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| Tetraspanin | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| PDI-like | 0 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | DIRECT |
| Histone deacetylase, HDAC | 0 | DIRECT |
| Amylase, catalytic domain | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| Erythroid transcription factor GATA-1 | 0 | DIRECT |
| NTF2-like | 0 | DIRECT |
| Ran binding protein zinc finger-like | 0 | DIRECT |
| Cyclin | 0 | DIRECT |
| PurM N-terminal domain-like | 0 | DIRECT |
| Polo-box duplicated region | 0 | DIRECT |
| beta 1,4 galactosyltransferase (b4GalT1) | 0 | DIRECT |
| Sec63 C-terminal domain-like | 0 | DIRECT |
| YbiA-like | 0 | DIRECT |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | DIRECT |
| Single strand DNA-binding domain, SSB | 0 | DIRECT |
| Clc chloride channel | 0 | DIRECT |
| DNA repair protein MutS, domain III | 0 | DIRECT |
| HD domain | 0 | DIRECT |
| Surp module (SWAP domain) | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| Type II DNA topoisomerase | 0 | DIRECT |
| RNA-polymerase beta-prime | 0 | DIRECT |
| CRAL/TRIO N-terminal domain | 0 | DIRECT |
| Skp1 dimerisation domain-like | 0 | DIRECT |
| Cadherin | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | DIRECT |
| Class II glutamine amidotransferases | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Epoxide hydrolase | 0 | DIRECT |
| Tim10/DDP | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
| Proteasome subunits | 0 | DIRECT |
| Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
| PEP carboxykinase C-terminal domain | 0 | DIRECT |
| EGF-type module | 0 | DIRECT |
| Poly(A) polymerase, PAP, N-terminal domain | 0 | DIRECT |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | DIRECT |
| Ribosomal protein S10 | 0 | DIRECT |
| Class I aldolase | 0 | DIRECT |
| Myeloperoxidase-like | 0 | DIRECT |
| 5' to 3' exonuclease catalytic domain | 0 | DIRECT |
| Heme-dependent catalases | 0 | DIRECT |
| Anticodon-binding domain | 0 | DIRECT |
| Aquaporin-like | 0 | DIRECT |
| Mitochondrial carrier | 0 | DIRECT |
| XPF/Rad1/Mus81 nuclease | 0 | DIRECT |
| Ras-binding domain, RBD | 0 | DIRECT |
| Bactericidal permeability-increasing protein, BPI | 0 | DIRECT |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | DIRECT |
| LacY-like proton/sugar symporter | 0 | DIRECT |
| YicI catalytic domain-like | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| Purine and uridine phosphorylases | 0 | DIRECT |
| Phosphate binding protein-like | 0 | DIRECT |
| Nucleosome core histones | 0 | DIRECT |
| Carbonic anhydrase | 0 | DIRECT |
| Tubulin, C-terminal domain | 0 | DIRECT |
| Gamma-glutamyltranspeptidase-like | 0 | DIRECT |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
| Hexokinase | 0 | DIRECT |
| Proprotein convertase P-domain | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | DIRECT |
| Annexin | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| Adenain-like | 0 | DIRECT |
| Pyk2-associated protein beta ARF-GAP domain | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| Hypothetical protein c14orf129, hspc210 | 0 | DIRECT |
| LDH N-terminal domain-like | 0 | DIRECT |
| First domain of FERM | 0 | DIRECT |
| NOL1/NOP2/sun | 0 | DIRECT |
| WGR domain | 0 | DIRECT |
| 1,3-glucuronyltransferase | 0 | DIRECT |
| Glutaminase | 0 | DIRECT |
| Biotin dependent carboxylase carboxyltransferase domain | 0 | DIRECT |
| DNA gyrase/MutL, second domain | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | DIRECT |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
| Actin/HSP70 | 0 | DIRECT |
| Reductases | 0 | DIRECT |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | DIRECT |
| Class I glutamine amidotransferases (GAT) | 0 | DIRECT |
| Glycerol kinase | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| ets domain | 0 | DIRECT |
| Pancreatic carboxypeptidase, activation domain | 0 | DIRECT |
| Cofilin-like | 0 | DIRECT |
| SMAD domain | 0 | DIRECT |
| Fibrinogen C-terminal domain-like | 0 | DIRECT |
| Linker histone H1/H5 | 0 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
| Chromo domain | 0 | DIRECT |
| Rap/Ran-GAP | 0 | DIRECT |
| RNA-polymerase beta | 0 | DIRECT |
| Anticodon-binding domain of Class II aaRS | 0 | DIRECT |
| Lactate & malate dehydrogenases, C-terminal domain | 0 | DIRECT |
| D-aminoacid oxidase-like | 0 | DIRECT |
| Sec63 N-terminal domain | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| AMPK-beta glycogen binding domain-like | 0 | DIRECT |
| Arginine methyltransferase | 0 | DIRECT |
| LEM domain | 0 | DIRECT |
| Aminoacid dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Intermediate filament protein, coiled coil region | 0 | DIRECT |
| Poly(A) polymerase, PAP, middle domain | 0 | DIRECT |
| Pancreatic carboxypeptidases | 0 | DIRECT |
| SAND domain | 0 | DIRECT |
| Ferredoxin reductase FAD-binding domain-like | 0 | DIRECT |
| p120GAP domain-like | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), catalytic domain | 0 | DIRECT |
| S-adenosylmethionine synthetase | 0 | DIRECT |
| Hormone receptor domain | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| Phosphotyrosine-binding domain (PTB) | 0 | DIRECT |
| Complement control module/SCR domain | 0 | DIRECT |
| HAT/Suf repeat | 0 | DIRECT |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | DIRECT |
| Glycolipid transfer protein, GLTP | 0 | DIRECT |
| Type II chitinase | 0 | DIRECT |
| beta-Lactamase/D-ala carboxypeptidase | 0 | DIRECT |
| HCDH C-domain-like | 0 | DIRECT |
| SAM (sterile alpha motif) domain | 0 | DIRECT |
| Myotubularin-like phosphatases | 0 | DIRECT |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | DIRECT |
| PABC (PABP) domain | 0 | DIRECT |
| Mammalian PLC | 0 | DIRECT |
| GYF domain | 0 | DIRECT |
| Clathrin adaptor core protein | 0 | DIRECT |
| La domain | 0 | DIRECT |
| Ubiquitin activating enzymes (UBA) | 0 | DIRECT |
| alpha-catenin/vinculin | 0 | DIRECT |
| Carboxypeptidase regulatory domain | 0 | DIRECT |
| DEATH domain, DD | 0 | DIRECT |
| Band 7/SPFH domain | 0 | DIRECT |
| CO dehydrogenase ISP C-domain like | 0 | DIRECT |
| Glycerophosphoryl diester phosphodiesterase | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| Nucleoside diphosphate kinase, NDK | 0 | DIRECT |
| Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
| CoA-binding domain | 0 | DIRECT |
| Molybdenum cofactor-binding domain | 0 | DIRECT |
| alpha-mannosidase, C-terminal domain | 0 | DIRECT |
| CAT-like | 0 | DIRECT |
| PLC-like (P variant) | 0 | DIRECT |
| PhzC/PhzF-like | 0 | DIRECT |
| BC ATP-binding domain-like | 0 | DIRECT |
| alpha-mannosidase | 0 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
| Tubulin, GTPase domain | 0 | DIRECT |
| UDP-glucose pyrophosphorylase | 0 | DIRECT |
| FtsH protease domain-like | 0 | DIRECT |
| Fatty acid binding protein-like | 0 | DIRECT |
| SCF ubiquitin ligase complex WHB domain | 0 | DIRECT |
| U-box | 0 | DIRECT |
| MOSC N-terminal domain-like | 0 | DIRECT |
| Regulator of G-protein signaling, RGS | 0 | DIRECT |
| Pepsin inhibitor-3 | 0 | DIRECT |
| Spectrin repeat | 0 | DIRECT |
| MIF4G domain-like | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| MutT-like | 0 | DIRECT |
| Elafin-like | 0 | DIRECT |
| Filamin repeat (rod domain) | 0 | DIRECT |
| Inositol monophosphatase/fructose-1,6-bisphosphatase-like | 0 | DIRECT |
| Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| L30e/L7ae ribosomal proteins | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Phosphoribosyltransferases (PRTases) | 0 | DIRECT |
| ATP-dependent protease Lon (La), catalytic domain | 0 | DIRECT |
| YWTD domain | 0 | DIRECT |
| Dual specificity phosphatase-like | 0 | DIRECT |
| Cytoplasmic domain of inward rectifier potassium channel | 0 | DIRECT |
| alpha-Amylases, C-terminal beta-sheet domain | 0 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
| Armadillo repeat | 0 | DIRECT |
| CUT domain | 0 | DIRECT |
| Paired domain | 0 | DIRECT |
| DPP6 N-terminal domain-like | 0 | DIRECT |
| CO dehydrogenase flavoprotein N-terminal domain-like | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| UBA domain | 0 | DIRECT |
| DNA gyrase/MutL, N-terminal domain | 0 | DIRECT |
| PUA domain | 0 | DIRECT |
| acyl-CoA oxidase N-terminal domains | 0 | DIRECT |
| ARID domain | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Arfaptin, Rac-binding fragment | 0 | DIRECT |
| Pleckstrin-homology domain (PH domain) | 0 | DIRECT |
| Tandem AAA-ATPase domain | 0.0003423 | DIRECT |
| Protein kinases, catalytic subunit | 0.01189 | INHERITED FROM: lipid synthesis increased || protein phosphorylation variant || egg laying response to food variant || alkaline pH chemotaxis variant || chemical response variant || metabolic pathway variant || oxygen response variant || mechanosensation variant || octanol chemotaxis defective || aldicarb response variant || protein modification variant || protein phosphorylation reduced || protein expression variant || second messenger mediated signaling variant || positive chemotaxis variant || drug induced gene expression variant || pathogen induced gene expression variant || conflicting sensory integration variant || protein subcellular localization variant || anoxia resistant || kinase activity reduced || copper response variant |
| G proteins | 0.03702 | INHERITED FROM: carbon dioxide avoidance variant || fat content variant || bacterially unswollen || aldicarb response variant || chemotaxis variant || osmotic integrity variant || chemosensory response variant || drug induced gene expression variant || organism metabolism processing variant || carbon dioxide response variant || protein subcellular localization variant || organism environmental stimulus response variant |
| Homeodomain | 0.0386 | INHERITED FROM: carbon dioxide avoidance variant || ectopic expression transgene || organism metabolism processing variant || level of transgene expression variant || carbon dioxide response variant || sexually dimorphic physiology variant |
| WD40-repeat | 0.04926 | INHERITED FROM: dauer defective || ivermectin resistant || osmotic avoidance variant || ivermectin response variant || antimicrobial gene expression variant || organism metabolism processing variant || protein aggregation induced behavior variant |
| MSP-like | 0.06859 | INHERITED FROM: dauer lifespan variant || fat content variant || slow growth || larval growth variant || lipid metabolism variant || developmental growth variant || dauer lifespan extended || larval arrest || dauer metabolism variant |
| SH2 domain | 0.07115 | INHERITED FROM: protein expression variant || level of protein expression variant || protein expression reduced |
| PDZ domain | 0.07164 | INHERITED FROM: aldicarb response variant || drug response variant || protein expression variant || egg laying serotonin variant |
| L-arabinose binding protein-like | 0.07164 | INHERITED FROM: magnesium chemotaxis defective || alkaline pH chemotaxis variant || cation positive chemotaxis defective || lithium chemotaxis defective || iodide chemotaxis defective || chemotaxis variant || iodide chemotaxis variant || anion positive chemotaxis defective || bromide chemotaxis variant || chemosensory response variant || bromide chemotaxis defective || cation positive chemotaxis variant || anion positive chemotaxis variant || organism environmental stimulus response variant |
| Acetyl-CoA synthetase-like | 0.08625 | INHERITED FROM: lipid metabolism variant |
| Canonical RBD | 0.09456 | INHERITED FROM: late larval arrest || RNA processing variant || mRNA export variant || no induction of antimicrobial peptide expression after infection || antimicrobial gene expression variant || organism metabolism processing variant || innate immune response variant || sick || starvation induced apoptosis variant || RNA expression variant |
| CCCH zinc finger | 0.1039 | INHERITED FROM: RNA metabolism variant || gene expression variant || transgene expression variant || ectopic expression transgene || mRNA expression ectopic |
| ABC transporter ATPase domain-like | 0.1071 | INHERITED FROM: metal response variant || cadmium response variant || colchicine hypersensitive || RNAi response variant |
| Tetratricopeptide repeat (TPR) | 0.1416 | INHERITED FROM: organism metabolism processing variant |
| Cold shock DNA-binding domain-like | 0.1509 | INHERITED FROM: mRNA surveillance defective || sick || nonsense mRNA accumulation |
| HLH, helix-loop-helix DNA-binding domain | 0.1644 | INHERITED FROM: fungal resistance increased || gene expression level reduced || ectopic expression transgene || lysine chemotaxis defective || pathogen resistance increased || RNA expression variant || hypoxia response variant |
| Adenylyl and guanylyl cyclase catalytic domain | 0.1644 | INHERITED FROM: magnesium chemotaxis defective || alkaline pH chemotaxis variant || cation positive chemotaxis defective || lithium chemotaxis defective || AWC odorant chemotaxis variant || iodide chemotaxis defective || osmotic avoidance variant || chemotaxis variant || iodide chemotaxis variant || anion positive chemotaxis defective || bromide chemotaxis variant || chemosensory response variant || second messenger mediated signaling variant || bromide chemotaxis defective || positive chemotaxis variant || cation positive chemotaxis variant || AWC odorant chemotaxis defective || carbon dioxide response variant || diacetyl chemotaxis variant || organism environmental stimulus response variant |
| Calcium ATPase, transduction domain A | 0.1989 | INHERITED FROM: drug hypersensitive || nicotine hypersensitive || organism environmental stimulus response variant |
| SH3-domain | 0.2307 | INHERITED FROM: aldicarb response variant || protein expression variant || protein expression reduced |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.2383 | INHERITED FROM: hypoxia resistant || gene expression variant || oxygen response variant || transgene expression increased || antimicrobial gene expression variant || paraquat resistant || organism metabolism processing variant || innate immune response variant || paraquat response variant || organism environmental stimulus response variant || hypoxia response variant |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.2383 | INHERITED FROM: hypoxia resistant || gene expression variant || oxygen response variant || transgene expression variant || organism metabolism processing variant || organism environmental stimulus response variant || hypoxia response variant |
| Extended PAW domain | 0.2383 | INHERITED FROM: protein interaction variant || protein aggregation variant || pattern of transgene expression variant || protein protein interaction variant || transgene subcellular localization variant |
| Elongation factors | 0.2383 | INHERITED FROM: protein aggregation variant || mRNA levels increased || protein phosphorylation increased || mRNA levels reduced || protein modification variant || protein protein interaction variant || proteasome core activity variant |
| DBL homology domain (DH-domain) | 0.2383 | INHERITED FROM: bacterially unswollen || aldicarb response variant || organism pathogen response variant || pathogen resistance increased || organism environmental stimulus response variant |
| Histone lysine methyltransferases | 0.2383 | INHERITED FROM: ectopic expression antibody || metabolic pathway variant || mRNA expression variant || life span variant || protein modification variant || shortened life span || protein expression variant || protein metabolism variant || somatic transgene silencing variant || protein methylation variant || RNAi response variant || histone methylation variant || maintenance of gene silencing variant |
| Pepsin-like | 0.2383 | INHERITED FROM: protein interaction variant || protein aggregation variant || pattern of transgene expression variant || gene expression variant || transgene expression variant || osmotic integrity variant || hypoosmotic shock hypersensitive || protein protein interaction variant || transgene subcellular localization variant || organism metabolism processing variant |
| Acetylcholinesterase-like | 0.2581 | INHERITED FROM: acetylcholinesterase activity variant || acetylcholinesterase reduced || enzyme activity reduced || enzyme activity variant |
| HMG-box | 0.2605 | INHERITED FROM: maintenance of gene silencing variant |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.285 | INHERITED FROM: drug hypersensitive || nicotine hypersensitive || organism environmental stimulus response variant |
| Extended AAA-ATPase domain | 0.3065 | INHERITED FROM: spontaneous mutation rate increased || life span variant || protein expression increased || sick |
| Multidrug efflux transporter AcrB transmembrane domain | 0.3077 | INHERITED FROM: embryo osmotic integrity defective early emb || positive chemotaxis defective || chemotaxis variant || egg integrity defective early emb || odorant chemosensory response variant || odorant positive chemotaxis defective |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 0.312 | INHERITED FROM: fat content variant || lipid metabolism variant |
| Bromodomain | 0.312 | INHERITED FROM: anesthetic resistant || organism stress response variant || acute functional tolerance to alcohol defective || anesthetic response variant || ethanol resistant || organism UV response variant || drug adaptation variant || sick || organism UV hypersensitive |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0.312 | INHERITED FROM: acetylcholinesterase inhibitor resistant || aldicarb resistant |
| Ankyrin repeat | 0.3134 | INHERITED FROM: organism stress response variant || octanol chemotaxis defective || organism heat response variant || odorant negative chemotaxis defective || octanol chemotaxis variant |
| Cytochrome P450 | 0.3286 | INHERITED FROM: metal response variant || cadmium response variant |
| FAD/NAD-linked reductases, N-terminal and central domains | 0.3407 | INHERITED FROM: pesticide response variant || organism oxidative stress response variant || paraquat response variant |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.3735 | INHERITED FROM: protein aggregation variant || pattern of transgene expression variant || life span variant || pattern protein expression variant || protein protein interaction variant || protein subcellular localization variant || sick |
| Meta-cation ATPase, catalytic domain P | 0.3735 | INHERITED FROM: nicotine hypersensitive || organism environmental stimulus response variant |
| Crotonase-like | 0.3735 | INHERITED FROM: fat content variant || lipid metabolism variant |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.4051 | INHERITED FROM: chemical response variant || nicotine resistant || mechanosensation variant || aqueous chemosensory response variant || cholinergic agonist resistant || selenium response variant || DMPP response variant || sodium chloride chemotaxis variant || drug response variant || hypoosmotic shock hypersensitive || slowing response on food variant || antihelmintic response variant || organism environmental stimulus response variant |
| TBP-associated factors, TAFs | 0.4059 | INHERITED FROM: transgene expression variant |
| Pumilio repeat | 0.4433 | INHERITED FROM: protein expression ectopic |
| GABA-aminotransferase-like | 0.4433 | INHERITED FROM: fat content reduced |
| FKBP immunophilin/proline isomerase | 0.4572 | INHERITED FROM: protein interaction variant || protein aggregation variant || pattern of transgene expression variant || protein protein interaction variant || transgene subcellular localization variant |
| ABC transporter transmembrane region | 0.4658 | INHERITED FROM: metal response variant || cadmium response variant || colchicine hypersensitive || RNAi response variant || organism environmental stimulus response variant |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.4765 | INHERITED FROM: aldicarb response variant || odorant positive chemotaxis variant || antimicrobial gene expression variant || drug induced gene expression variant || organism pathogen response variant || odorant chemosensory response variant || nose touch variant || protein subcellular localization variant || drug resistant |
| Cation efflux protein transmembrane domain-like | 0.4815 | INHERITED FROM: manganese toxicity resistant || cadmium hypersensitive || manganese response variant || metal response variant || cadmium response variant |
| Glutathione S-transferase (GST), N-terminal domain | 0.5095 | INHERITED FROM: organism stress response variant || cadmium hypersensitive || organism heat hypersensitive || organism electrophilic stress hypersensitive || enzyme activity reduced || paraquat response variant || organism environmental stimulus response variant || enzyme activity variant |
| Hect, E3 ligase catalytic domain | 0.5257 | INHERITED FROM: protein interaction variant || protein aggregation variant || pattern of transgene expression variant || gene expression variant || transgene expression variant || protein protein interaction variant || transgene subcellular localization variant || organism metabolism processing variant || protein aggregation induced behavior variant |
| Pyridoxal-dependent decarboxylase | 0.5257 | INHERITED FROM: carbon dioxide avoidance variant || egg laying response to drug variant || carbon dioxide response variant |
| Nicotinic receptor ligand binding domain-like | 0.538 | INHERITED FROM: chemical response variant || nicotine resistant || mechanosensation variant || aqueous chemosensory response variant || cholinergic agonist resistant || selenium response variant || DMPP response variant || sodium chloride chemotaxis variant || drug response variant || hypoosmotic shock hypersensitive || slowing response on food variant || antihelmintic response variant || organism environmental stimulus response variant |
| I set domains | 0.565 | INHERITED FROM: aldicarb resistant || aldicarb response variant || protein degradation variant || growth rate variant || organism environmental stimulus response variant |
| Gastric lipase | 0.5698 | INHERITED FROM: fat content variant || lipid metabolism variant |
| Calpain large subunit, middle domain (domain III) | 0.5698 | INHERITED FROM: metabolic pathway variant || protein degradation variant || protein metabolism variant |
| Myb/SANT domain | 0.5698 | INHERITED FROM: growth rate variant |
| Papain-like | 0.5846 | INHERITED FROM: protein interaction variant || protein aggregation variant || pattern of transgene expression variant || gene expression variant || transgene expression variant || osmotic integrity variant || hypoosmotic shock hypersensitive || protein protein interaction variant || organism metabolism processing variant |
| WW domain | 0.597 | INHERITED FROM: maintenance of gene silencing variant |
| Class I alpha-1;2-mannosidase, catalytic domain | 0.6209 | INHERITED FROM: protein aggregation variant || extended life span || protein protein interaction variant |
| UBC-related | 0.638 | INHERITED FROM: protein interaction variant || protein aggregation variant || pattern of transgene expression variant || late larval arrest || gene expression variant || transgene expression variant || protein protein interaction variant || transgene subcellular localization variant || organism metabolism processing variant |
| Synaptotagmin-like (S variant) | 0.6642 | INHERITED FROM: acetylcholinesterase inhibitor resistant || acetylcholinesterase inhibitor response variant || drug response variant || pattern protein expression variant || protein subcellular localization variant || drug resistant |
| Osmotin, thaumatin-like protein | 0.6757 | INHERITED FROM: cadmium hypersensitive || metal response variant || cadmium response variant |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0.6914 | INHERITED FROM: protein interaction variant || protein aggregation variant || pattern of transgene expression variant || gene expression variant || transgene expression variant || protein protein interaction variant || organism metabolism processing variant |
| BTB/POZ domain | 0.7049 | INHERITED FROM: chemical response variant || resistant to protein aggregation induced paralysis || early larval arrest || L1 arrest || protein aggregation induced behavior variant || chemical hypersensitive |
| Frizzled cysteine-rich domain | 0.7346 | INHERITED FROM: transgene expression reduced || antibody staining variant |
| EF-hand modules in multidomain proteins | 0.7346 | INHERITED FROM: protein expression variant |
| Transforming growth factor (TGF)-beta | 0.7346 | INHERITED FROM: levamisole response variant || drug response variant || transgene expression reduced || level of transgene expression variant || nicotine response variant |
| PHD domain | 0.7653 | INHERITED FROM: RNAi resistant || organism UV response variant || protein modification variant || ectopic expression transgene || protein methylation variant || RNAi response variant || organism environmental stimulus response variant || organism UV hypersensitive |
| H-NOX domain | 0.799 | INHERITED FROM: carbon dioxide avoidance variant || carbon dioxide response variant |
| Cdc48 N-terminal domain-like | 0.799 | INHERITED FROM: protein interaction variant || protein aggregation variant || metabolic pathway variant || transgene expression reduced || protein protein interaction variant || protein metabolism variant |
| Bacterial lipase | 0.799 | INHERITED FROM: fat content variant || lipid metabolism variant |
| MIT domain | 0.799 | INHERITED FROM: protein interaction variant || protein aggregation variant || protein protein interaction variant |
| Ubiquitin-related | 0.8019 | INHERITED FROM: protein interaction variant || protein aggregation variant || transgene expression variant || protein protein interaction variant || organism metabolism processing variant || hypersensitive to protein aggregation induced paralysis |
| Voltage-gated potassium channels | 0.8088 | INHERITED FROM: adrenergic receptor antagonist response variant || protein degradation variant || growth rate variant || serotonin response variant || AWA odorant chemotaxis variant || serotonin resistant |
| PAZ domain | 0.8661 | INHERITED FROM: mRNA levels increased || siRNA expression variant || 21U RNA expression variant || RNAi enhanced || RNAi response variant || RNA expression variant || maintenance of gene silencing variant |
| LIM domain | 0.8776 | INHERITED FROM: protein degradation variant || level of protein expression variant || protein expression reduced |
| Glutathione S-transferase (GST), C-terminal domain | 0.9097 | INHERITED FROM: organism stress response variant || cadmium hypersensitive || organism electrophilic stress hypersensitive || enzyme activity reduced || organism environmental stimulus response variant || enzyme activity variant |
| Leucine zipper domain | 0.9177 | INHERITED FROM: mRNA levels reduced || transgene expression reduced || pathogen susceptibility increased || level of transgene expression variant || pore forming toxin response variant |
| DnaQ-like 3'-5' exonuclease | 0.926 | INHERITED FROM: RNAi response variant |
| Calmodulin-like | 0.9421 | INHERITED FROM: protein interaction variant || protein aggregation variant || protein protein interaction variant || transgene subcellular localization variant |
| Nuclear receptor ligand-binding domain | 0.9443 | INHERITED FROM: dauer resistance to harsh conditions variant || fat content increased || gene expression level high || gene expression level reduced || lipid metabolism variant || transgene expression reduced || SDS sensitive dauer |
| Ribonuclease PH domain 2-like | 0.9756 | INHERITED FROM: early larval arrest |
| NagD-like | 0.9756 | INHERITED FROM: dauer constitutive || dauer formation variant |
| Ribonuclease PH domain 1-like | 0.9756 | INHERITED FROM: early larval arrest |
| Choline/Carnitine O-acyltransferase | 1 | INHERITED FROM: fat content variant || lipid metabolism variant |
| RING finger domain, C3HC4 | 1 | INHERITED FROM: protein interaction variant || protein aggregation variant || pattern of transgene expression variant || protein protein interaction variant || transgene subcellular localization variant || organism metabolism processing variant |
| F-box domain | 1 | INHERITED FROM: resistant to protein aggregation induced paralysis || protein aggregation induced behavior variant |
| Rhodopsin-like | 1 | INHERITED FROM: serotonin hypersensitive || serotonin induced fat reduction variant || biogenic amine receptor antagonist resistant || aqueous adaptation defective || male tail curling serotonin variant || egg laying response to drug variant || drug withdrawal response variant || organism pathogen response variant || serotonin response variant || locomotion rate serotonin variant || serotonin induced pumping variant || serotonin resistant |
| Nuclear receptor | 1 | INHERITED FROM: dauer resistance to harsh conditions variant || fat content increased || gene expression level high || gene expression level reduced || transgene expression reduced || SDS sensitive dauer |
| C-type lectin domain | 1 | INHERITED FROM: pathogen induced death increased |
| N-acetyl transferase, NAT | 1 | INHERITED FROM: ectopic expression transgene |
| Cyclophilin (peptidylprolyl isomerase) | 1 | INHERITED FROM: protein interaction variant || protein aggregation variant || pattern of transgene expression variant || transgene expression variant || protein protein interaction variant || transgene subcellular localization variant |
| Glutathione peroxidase-like | 1 | INHERITED FROM: pesticide response variant || paraquat response variant |
| B-box zinc-binding domain | 1 | INHERITED FROM: protein interaction variant || protein aggregation variant || gene expression variant || transgene expression variant || protein protein interaction variant || transgene subcellular localization variant |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Clathrin coat assembly domain | 0 | Direct |
| Oxysterol-binding protein | 0 | Direct |
| Peptidylglycine alpha-hydroxylating monooxygenase, PHM | 0 | Direct |
| POU-specific domain | 0 | Direct |
| Translation initiation factor eIF4e | 0 | Direct |
| Cullin repeat | 0 | Direct |
| Chaperone J-domain | 0 | Direct |
| Hydantoinase (dihydropyrimidinase) | 0 | Direct |
| YihX-like | 0 | Direct |
| WWE domain | 0 | Direct |
| AAT-like | 0 | Direct |
| Methionine aminopeptidase, insert domain | 0 | Direct |
| Trunk domain of Sec23/24 | 0 | Direct |
| Chitinase insertion domain | 0 | Direct |
| Small-conductance potassium channel | 0 | Direct |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
| PurM C-terminal domain-like | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | Direct |
| Profilin (actin-binding protein) | 0 | Direct |
| Acyl-carrier protein (ACP) | 0 | Direct |
| Acireductone dioxygenase | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| 28-residue LRR | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| Doublecortin (DC) | 0 | Direct |
| RecA protein-like (ATPase-domain) | 0 | Direct |
| Alcohol dehydrogenase-like, N-terminal domain | 0 | Direct |
| Translational machinery components | 0 | Direct |
| cAMP-binding domain | 0 | Direct |
| GAS2 domain | 0 | Direct |
| COMT-like | 0 | Direct |
| SWIRM domain | 0 | Direct |
| PDEase | 0 | Direct |
| Troponin I | 0 | Direct |
| Acyl-CoA thioesterase | 0 | Direct |
| MFPT repeat | 0 | Direct |
| Arylsulfatase | 0 | Direct |
| BEACH domain | 0 | Direct |
| Glycosyl transferases group 1 | 0 | Direct |
| BC C-terminal domain-like | 0 | Direct |
| LysM domain | 0 | Direct |
| DPP6 catalytic domain-like | 0 | Direct |
| Transducin (alpha subunit), insertion domain | 0 | Direct |
| HSP40/DnaJ peptide-binding domain | 0 | Direct |
| Brix domain | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| Protein prenyltransferases | 0 | Direct |
| BC N-terminal domain-like | 0 | Direct |
| acyl-CoA oxidase C-terminal domains | 0 | Direct |
| Ribosomal protein L1 | 0 | Direct |
| VHS domain | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Sir2 family of transcriptional regulators | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
| Subtilases | 0 | Direct |
| Poly(ADP-ribose) polymerase, C-terminal domain | 0 | Direct |
| Poly(A) polymerase, PAP, C-terminal domain | 0 | Direct |
| Acylamino-acid-releasing enzyme, C-terminal donain | 0 | Direct |
| Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
| Third domain of FERM | 0 | Direct |
| Thyroglobulin type-1 domain | 0 | Direct |
| Double-stranded RNA-binding domain (dsRBD) | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Sterol carrier protein, SCP | 0 | Direct |
| Thiolase-related | 0 | Direct |
| Cell cycle control phosphatase, catalytic domain | 0 | Direct |
| Quinoprotein alcohol dehydrogenase-like | 0 | Direct |
| Inositol polyphosphate kinase (IPK) | 0 | Direct |
| GAPDH-like | 0 | Direct |
| PaaI/YdiI-like | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| Hsp90 middle domain | 0 | Direct |
| Ribosomal protein L18 and S11 | 0 | Direct |
| t-snare proteins | 0 | Direct |
| Phosphatidylethanolamine binding protein | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| ALDH-like | 0 | Direct |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | Direct |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | Direct |
| Nop domain | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| Choline kinase | 0 | Direct |
| HEAT repeat | 0 | Direct |
| alpha-mannosidase, domain 2 | 0 | Direct |
| Laminin G-like module | 0 | Direct |
| DEP domain | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| Ribokinase-like | 0 | Direct |
| BAR domain | 0 | Direct |
| Adenosine/AMP deaminase | 0 | Direct |
| D-aminoacid oxidase, N-terminal domain | 0 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| a tRNA synthase domain | 0 | Direct |
| Glycogenin | 0 | Direct |
| RNA editing terminal uridyl transferase 2, RET2, domain 2 | 0 | Direct |
| Ngr ectodomain-like | 0 | Direct |
| Matrix metalloproteases, catalytic domain | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain | 0 | Direct |
| Biotinyl/lipoyl-carrier proteins and domains | 0 | Direct |
| Insulin-like | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | Direct |
| L-aminoacid/polyamine oxidase | 0 | Direct |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0 | Direct |
| Reprolysin-like | 0 | Direct |
| NHL repeat | 0 | Direct |
| Hedgehog C-terminal (Hog) autoprocessing domain | 0 | Direct |
| Second domain of FERM | 0 | Direct |
| Hydantoinase (dihydropyrimidinase), catalytic domain | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Formate/glycerate dehydrogenases, NAD-domain | 0 | Direct |
| Alcohol dehydrogenase-like, C-terminal domain | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
| Sec7 domain | 0 | Direct |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0 | Direct |
| IF2B-like | 0 | Direct |
| FHA domain | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| AN1-like Zinc finger | 0 | Direct |
| Calpain large subunit, catalytic domain (domain II) | 0 | Direct |
| Citrate synthase | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| Calcium ATPase, transmembrane domain M | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| RhoGDI-like | 0 | Direct |
| Regulator of chromosome condensation RCC1 | 0 | Direct |
| Internalin LRR domain | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | Direct |
| Cdc48 domain 2-like | 0 | Direct |
| Ribonucleotide reductase-like | 0 | Direct |
| HSP20 | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| Tetraspanin | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| PDI-like | 0 | Direct |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | Direct |
| Histone deacetylase, HDAC | 0 | Direct |
| Amylase, catalytic domain | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| Erythroid transcription factor GATA-1 | 0 | Direct |
| NTF2-like | 0 | Direct |
| Ran binding protein zinc finger-like | 0 | Direct |
| Cyclin | 0 | Direct |
| PurM N-terminal domain-like | 0 | Direct |
| Polo-box duplicated region | 0 | Direct |
| beta 1,4 galactosyltransferase (b4GalT1) | 0 | Direct |
| Sec63 C-terminal domain-like | 0 | Direct |
| YbiA-like | 0 | Direct |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | Direct |
| Single strand DNA-binding domain, SSB | 0 | Direct |
| Clc chloride channel | 0 | Direct |
| DNA repair protein MutS, domain III | 0 | Direct |
| HD domain | 0 | Direct |
| Surp module (SWAP domain) | 0 | Direct |
| Integrin domains | 0 | Direct |
| Type II DNA topoisomerase | 0 | Direct |
| RNA-polymerase beta-prime | 0 | Direct |
| CRAL/TRIO N-terminal domain | 0 | Direct |
| Skp1 dimerisation domain-like | 0 | Direct |
| Cadherin | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | Direct |
| Class II glutamine amidotransferases | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Epoxide hydrolase | 0 | Direct |
| Tim10/DDP | 0 | Direct |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
| Proteasome subunits | 0 | Direct |
| Blood coagulation inhibitor (disintegrin) | 0 | Direct |
| PEP carboxykinase C-terminal domain | 0 | Direct |
| EGF-type module | 0 | Direct |
| Poly(A) polymerase, PAP, N-terminal domain | 0 | Direct |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | Direct |
| Ribosomal protein S10 | 0 | Direct |
| Class I aldolase | 0 | Direct |
| Myeloperoxidase-like | 0 | Direct |
| 5' to 3' exonuclease catalytic domain | 0 | Direct |
| Heme-dependent catalases | 0 | Direct |
| Anticodon-binding domain | 0 | Direct |
| Aquaporin-like | 0 | Direct |
| Mitochondrial carrier | 0 | Direct |
| XPF/Rad1/Mus81 nuclease | 0 | Direct |
| Ras-binding domain, RBD | 0 | Direct |
| Bactericidal permeability-increasing protein, BPI | 0 | Direct |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | Direct |
| LacY-like proton/sugar symporter | 0 | Direct |
| YicI catalytic domain-like | 0 | Direct |
| Proton glutamate symport protein | 0 | Direct |
| Purine and uridine phosphorylases | 0 | Direct |
| Phosphate binding protein-like | 0 | Direct |
| Nucleosome core histones | 0 | Direct |
| Carbonic anhydrase | 0 | Direct |
| Tubulin, C-terminal domain | 0 | Direct |
| Gamma-glutamyltranspeptidase-like | 0 | Direct |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
| Hexokinase | 0 | Direct |
| Proprotein convertase P-domain | 0 | Direct |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | Direct |
| Annexin | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| Adenain-like | 0 | Direct |
| Pyk2-associated protein beta ARF-GAP domain | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| Hypothetical protein c14orf129, hspc210 | 0 | Direct |
| LDH N-terminal domain-like | 0 | Direct |
| First domain of FERM | 0 | Direct |
| NOL1/NOP2/sun | 0 | Direct |
| WGR domain | 0 | Direct |
| 1,3-glucuronyltransferase | 0 | Direct |
| Glutaminase | 0 | Direct |
| Biotin dependent carboxylase carboxyltransferase domain | 0 | Direct |
| DNA gyrase/MutL, second domain | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | Direct |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
| Actin/HSP70 | 0 | Direct |
| Reductases | 0 | Direct |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | Direct |
| Class I glutamine amidotransferases (GAT) | 0 | Direct |
| Glycerol kinase | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| ets domain | 0 | Direct |
| Pancreatic carboxypeptidase, activation domain | 0 | Direct |
| Cofilin-like | 0 | Direct |
| SMAD domain | 0 | Direct |
| Fibrinogen C-terminal domain-like | 0 | Direct |
| Linker histone H1/H5 | 0 | Direct |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
| Chromo domain | 0 | Direct |
| Rap/Ran-GAP | 0 | Direct |
| RNA-polymerase beta | 0 | Direct |
| Anticodon-binding domain of Class II aaRS | 0 | Direct |
| Lactate & malate dehydrogenases, C-terminal domain | 0 | Direct |
| D-aminoacid oxidase-like | 0 | Direct |
| Sec63 N-terminal domain | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| AMPK-beta glycogen binding domain-like | 0 | Direct |
| Arginine methyltransferase | 0 | Direct |
| LEM domain | 0 | Direct |
| Aminoacid dehydrogenase-like, C-terminal domain | 0 | Direct |
| Intermediate filament protein, coiled coil region | 0 | Direct |
| Poly(A) polymerase, PAP, middle domain | 0 | Direct |
| Pancreatic carboxypeptidases | 0 | Direct |
| SAND domain | 0 | Direct |
| Ferredoxin reductase FAD-binding domain-like | 0 | Direct |
| p120GAP domain-like | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), catalytic domain | 0 | Direct |
| S-adenosylmethionine synthetase | 0 | Direct |
| Hormone receptor domain | 0 | Direct |
| MIR domain | 0 | Direct |
| Phosphotyrosine-binding domain (PTB) | 0 | Direct |
| Complement control module/SCR domain | 0 | Direct |
| HAT/Suf repeat | 0 | Direct |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | Direct |
| Glycolipid transfer protein, GLTP | 0 | Direct |
| Type II chitinase | 0 | Direct |
| beta-Lactamase/D-ala carboxypeptidase | 0 | Direct |
| HCDH C-domain-like | 0 | Direct |
| SAM (sterile alpha motif) domain | 0 | Direct |
| Myotubularin-like phosphatases | 0 | Direct |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | Direct |
| PABC (PABP) domain | 0 | Direct |
| Mammalian PLC | 0 | Direct |
| GYF domain | 0 | Direct |
| Clathrin adaptor core protein | 0 | Direct |
| La domain | 0 | Direct |
| Ubiquitin activating enzymes (UBA) | 0 | Direct |
| alpha-catenin/vinculin | 0 | Direct |
| Carboxypeptidase regulatory domain | 0 | Direct |
| DEATH domain, DD | 0 | Direct |
| Band 7/SPFH domain | 0 | Direct |
| CO dehydrogenase ISP C-domain like | 0 | Direct |
| Glycerophosphoryl diester phosphodiesterase | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| FF domain | 0 | Direct |
| Nucleoside diphosphate kinase, NDK | 0 | Direct |
| Cation efflux protein cytoplasmic domain-like | 0 | Direct |
| CoA-binding domain | 0 | Direct |
| Molybdenum cofactor-binding domain | 0 | Direct |
| alpha-mannosidase, C-terminal domain | 0 | Direct |
| CAT-like | 0 | Direct |
| PLC-like (P variant) | 0 | Direct |
| PhzC/PhzF-like | 0 | Direct |
| BC ATP-binding domain-like | 0 | Direct |
| alpha-mannosidase | 0 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
| Tubulin, GTPase domain | 0 | Direct |
| UDP-glucose pyrophosphorylase | 0 | Direct |
| FtsH protease domain-like | 0 | Direct |
| Fatty acid binding protein-like | 0 | Direct |
| SCF ubiquitin ligase complex WHB domain | 0 | Direct |
| U-box | 0 | Direct |
| MOSC N-terminal domain-like | 0 | Direct |
| Regulator of G-protein signaling, RGS | 0 | Direct |
| Pepsin inhibitor-3 | 0 | Direct |
| Spectrin repeat | 0 | Direct |
| MIF4G domain-like | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| MutT-like | 0 | Direct |
| Elafin-like | 0 | Direct |
| Filamin repeat (rod domain) | 0 | Direct |
| Inositol monophosphatase/fructose-1,6-bisphosphatase-like | 0 | Direct |
| Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 0 | Direct |
| L30e/L7ae ribosomal proteins | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Phosphoribosyltransferases (PRTases) | 0 | Direct |
| ATP-dependent protease Lon (La), catalytic domain | 0 | Direct |
| YWTD domain | 0 | Direct |
| Dual specificity phosphatase-like | 0 | Direct |
| Cytoplasmic domain of inward rectifier potassium channel | 0 | Direct |
| alpha-Amylases, C-terminal beta-sheet domain | 0 | Direct |
| Bacterial exopeptidase dimerisation domain | 0 | Direct |
| Armadillo repeat | 0 | Direct |
| CUT domain | 0 | Direct |
| Paired domain | 0 | Direct |
| DPP6 N-terminal domain-like | 0 | Direct |
| CO dehydrogenase flavoprotein N-terminal domain-like | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| UBA domain | 0 | Direct |
| DNA gyrase/MutL, N-terminal domain | 0 | Direct |
| PUA domain | 0 | Direct |
| acyl-CoA oxidase N-terminal domains | 0 | Direct |
| ARID domain | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Arfaptin, Rac-binding fragment | 0 | Direct |
| Pleckstrin-homology domain (PH domain) | 0 | Direct |
| Tandem AAA-ATPase domain | 0.0003423 | Direct |
| Protein kinases, catalytic subunit | 0.01189 | Inherited |
| G proteins | 0.03702 | Inherited |
| Homeodomain | 0.0386 | Inherited |
| WD40-repeat | 0.04926 | Inherited |
| MSP-like | 0.06859 | Inherited |
| SH2 domain | 0.07115 | Inherited |
| PDZ domain | 0.07164 | Inherited |
| L-arabinose binding protein-like | 0.07164 | Inherited |
| Acetyl-CoA synthetase-like | 0.08625 | Inherited |
| Canonical RBD | 0.09456 | Inherited |
| CCCH zinc finger | 0.1039 | Inherited |
| ABC transporter ATPase domain-like | 0.1071 | Inherited |
| Tetratricopeptide repeat (TPR) | 0.1416 | Inherited |
| Cold shock DNA-binding domain-like | 0.1509 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.1644 | Inherited |
| Adenylyl and guanylyl cyclase catalytic domain | 0.1644 | Inherited |
| Calcium ATPase, transduction domain A | 0.1989 | Inherited |
| SH3-domain | 0.2307 | Inherited |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.2383 | Inherited |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.2383 | Inherited |
| Extended PAW domain | 0.2383 | Inherited |
| Elongation factors | 0.2383 | Inherited |
| DBL homology domain (DH-domain) | 0.2383 | Inherited |
| Histone lysine methyltransferases | 0.2383 | Inherited |
| Pepsin-like | 0.2383 | Inherited |
| Acetylcholinesterase-like | 0.2581 | Inherited |
| HMG-box | 0.2605 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.285 | Inherited |
| Extended AAA-ATPase domain | 0.3065 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.3077 | Inherited |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 0.312 | Inherited |
| Bromodomain | 0.312 | Inherited |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0.312 | Inherited |
| Ankyrin repeat | 0.3134 | Inherited |
| Cytochrome P450 | 0.3286 | Inherited |
| FAD/NAD-linked reductases, N-terminal and central domains | 0.3407 | Inherited |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.3735 | Inherited |
| Meta-cation ATPase, catalytic domain P | 0.3735 | Inherited |
| Crotonase-like | 0.3735 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.4051 | Inherited |
| TBP-associated factors, TAFs | 0.4059 | Inherited |
| Pumilio repeat | 0.4433 | Inherited |
| GABA-aminotransferase-like | 0.4433 | Inherited |
| FKBP immunophilin/proline isomerase | 0.4572 | Inherited |
| ABC transporter transmembrane region | 0.4658 | Inherited |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.4765 | Inherited |
| Cation efflux protein transmembrane domain-like | 0.4815 | Inherited |
| Glutathione S-transferase (GST), N-terminal domain | 0.5095 | Inherited |
| Hect, E3 ligase catalytic domain | 0.5257 | Inherited |
| Pyridoxal-dependent decarboxylase | 0.5257 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.538 | Inherited |
| I set domains | 0.565 | Inherited |
| Gastric lipase | 0.5698 | Inherited |
| Calpain large subunit, middle domain (domain III) | 0.5698 | Inherited |
| Myb/SANT domain | 0.5698 | Inherited |
| Papain-like | 0.5846 | Inherited |
| WW domain | 0.597 | Inherited |
| Class I alpha-1;2-mannosidase, catalytic domain | 0.6209 | Inherited |
| UBC-related | 0.638 | Inherited |
| Synaptotagmin-like (S variant) | 0.6642 | Inherited |
| Osmotin, thaumatin-like protein | 0.6757 | Inherited |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0.6914 | Inherited |
| BTB/POZ domain | 0.7049 | Inherited |
| Frizzled cysteine-rich domain | 0.7346 | Inherited |
| EF-hand modules in multidomain proteins | 0.7346 | Inherited |
| Transforming growth factor (TGF)-beta | 0.7346 | Inherited |
| PHD domain | 0.7653 | Inherited |
| H-NOX domain | 0.799 | Inherited |
| Cdc48 N-terminal domain-like | 0.799 | Inherited |
| Bacterial lipase | 0.799 | Inherited |
| MIT domain | 0.799 | Inherited |
| Ubiquitin-related | 0.8019 | Inherited |
| Voltage-gated potassium channels | 0.8088 | Inherited |
| PAZ domain | 0.8661 | Inherited |
| LIM domain | 0.8776 | Inherited |
| Glutathione S-transferase (GST), C-terminal domain | 0.9097 | Inherited |
| Leucine zipper domain | 0.9177 | Inherited |
| DnaQ-like 3'-5' exonuclease | 0.926 | Inherited |
| Calmodulin-like | 0.9421 | Inherited |
| Nuclear receptor ligand-binding domain | 0.9443 | Inherited |
| Ribonuclease PH domain 2-like | 0.9756 | Inherited |
| NagD-like | 0.9756 | Inherited |
| Ribonuclease PH domain 1-like | 0.9756 | Inherited |
| Choline/Carnitine O-acyltransferase | 1 | Inherited |
| RING finger domain, C3HC4 | 1 | Inherited |
| F-box domain | 1 | Inherited |
| Rhodopsin-like | 1 | Inherited |
| Nuclear receptor | 1 | Inherited |
| C-type lectin domain | 1 | Inherited |
| N-acetyl transferase, NAT | 1 | Inherited |
| Cyclophilin (peptidylprolyl isomerase) | 1 | Inherited |
| Glutathione peroxidase-like | 1 | Inherited |
| B-box zinc-binding domain | 1 | Inherited |
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A presence/absence matrix is generated using protein domain
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this WP term (Not in SPWP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
| Outer arm dynein light chain 1 | 0 | DIRECT |
| Ribosomal L27 protein-like | 0 | DIRECT |
| DNA repair protein MutS, domain III | 0 | DIRECT |
| Polo-box domain | 0 | DIRECT |
| Kringle-like | 0 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
| Mitochondrial carrier | 0 | DIRECT |
| MFPT repeat-like | 0 | DIRECT |
| ADP-ribosylation | 0 | DIRECT |
| GroEL equatorial domain-like | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| beta-lactamase/transpeptidase-like | 0 | DIRECT |
| ArfGap/RecO-like zinc finger | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
| Restriction endonuclease-like | 0 | DIRECT |
| eIF4e-like | 0 | DIRECT |
| Chaperone J-domain | 0 | DIRECT |
| Thiolase-like | 0 | DIRECT |
| Surp module (SWAP domain) | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| Pentein | 0 | DIRECT |
| Subtilisin-like | 0 | DIRECT |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| Ribosomal protein L1 | 0 | DIRECT |
| Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
| RBP11-like subunits of RNA polymerase | 0 | DIRECT |
| Type II DNA topoisomerase | 0 | DIRECT |
| PABC (PABP) domain | 0 | DIRECT |
| Invertebrate chitin-binding proteins | 0 | DIRECT |
| Cadherin-like | 0 | DIRECT |
| Chitinase insertion domain | 0 | DIRECT |
| dsRNA-binding domain-like | 0 | DIRECT |
| Profilin (actin-binding protein) | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | DIRECT |
| LysM domain | 0 | DIRECT |
| PAP/OAS1 substrate-binding domain | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| CBD9-like | 0 | DIRECT |
| HCP-like | 0 | DIRECT |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| Class II aaRS ABD-related | 0 | DIRECT |
| alpha/beta knot | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
| Skp1 dimerisation domain-like | 0 | DIRECT |
| Cdc48 domain 2-like | 0 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
| LEM domain | 0 | DIRECT |
| Activating enzymes of the ubiquitin-like proteins | 0 | DIRECT |
| Citrate synthase | 0 | DIRECT |
| Heme-dependent peroxidases | 0 | DIRECT |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| MOSC N-terminal domain-like | 0 | DIRECT |
| GroES-like | 0 | DIRECT |
| Aldolase | 0 | DIRECT |
| Small-conductance potassium channel | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| lambda repressor-like DNA-binding domains | 0 | DIRECT |
| GAT-like domain | 0 | DIRECT |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | DIRECT |
| Ran binding protein zinc finger-like | 0 | DIRECT |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| Rap/Ran-GAP | 0 | DIRECT |
| Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
| MgtE membrane domain-like | 0 | DIRECT |
| FtsH protease domain-like | 0 | DIRECT |
| PurM N-terminal domain-like | 0 | DIRECT |
| Chromo domain-like | 0 | DIRECT |
| Tubby C-terminal domain-like | 0 | DIRECT |
| Annexin | 0 | DIRECT |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0 | DIRECT |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
| TK C-terminal domain-like | 0 | DIRECT |
| R3H domain | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| Translational machinery components | 0 | DIRECT |
| Tubulin nucleotide-binding domain-like | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| 2Fe-2S ferredoxin-like | 0 | DIRECT |
| t-snare proteins | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| Creatinase/prolidase N-terminal domain | 0 | DIRECT |
| Nucleoporin domain | 0 | DIRECT |
| Aquaporin-like | 0 | DIRECT |
| Galactose mutarotase-like | 0 | DIRECT |
| PK beta-barrel domain-like | 0 | DIRECT |
| SAND domain-like | 0 | DIRECT |
| SCP-like | 0 | DIRECT |
| Class I glutamine amidotransferase-like | 0 | DIRECT |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| Thyroglobulin type-1 domain | 0 | DIRECT |
| Oxysterol-binding protein-like | 0 | DIRECT |
| PIN domain-like | 0 | DIRECT |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| Spectrin repeat | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| Arginase/deacetylase | 0 | DIRECT |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
| Tubulin C-terminal domain-like | 0 | DIRECT |
| YWTD domain | 0 | DIRECT |
| CRAL/TRIO N-terminal domain | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| Galactose oxidase, central domain | 0 | DIRECT |
| Clc chloride channel | 0 | DIRECT |
| Fibrinogen C-terminal domain-like | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Periplasmic binding protein-like II | 0 | DIRECT |
| Intermediate filament protein, coiled coil region | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| GroEL-intermediate domain like | 0 | DIRECT |
| CAD & PB1 domains | 0 | DIRECT |
| ENTH/VHS domain | 0 | DIRECT |
| SIS domain | 0 | DIRECT |
| Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
| S-adenosylmethionine synthetase | 0 | DIRECT |
| Purine and uridine phosphorylases | 0 | DIRECT |
| PYP-like sensor domain (PAS domain) | 0 | DIRECT |
| Second domain of FERM | 0 | DIRECT |
| Ribokinase-like | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| Ribosomal proteins S24e, L23 and L15e | 0 | DIRECT |
| Sec63 N-terminal domain-like | 0 | DIRECT |
| Cystatin/monellin | 0 | DIRECT |
| L30e-like | 0 | DIRECT |
| Actin-like ATPase domain | 0 | DIRECT |
| PUA domain-like | 0 | DIRECT |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | DIRECT |
| Protease propeptides/inhibitors | 0 | DIRECT |
| Phoshotransferase/anion transport protein | 0 | DIRECT |
| Carbohydrate phosphatase | 0 | DIRECT |
| GYF domain | 0 | DIRECT |
| PEP carboxykinase-like | 0 | DIRECT |
| Ribosomal protein S10 | 0 | DIRECT |
| Zn-binding ribosomal proteins | 0 | DIRECT |
| Tim10-like | 0 | DIRECT |
| YbiA-like | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| Ribosomal protein L10-like | 0 | DIRECT |
| Diaminopimelate epimerase-like | 0 | DIRECT |
| cAMP-binding domain-like | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| Carbonic anhydrase | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| SAICAR synthase-like | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| Putative DNA-binding domain | 0 | DIRECT |
| HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| BEACH domain | 0 | DIRECT |
| alpha-catenin/vinculin-like | 0 | DIRECT |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| Hormone receptor domain | 0 | DIRECT |
| Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
| WWE domain | 0 | DIRECT |
| Single hybrid motif | 0 | DIRECT |
| Acyl-CoA dehydrogenase NM domain-like | 0 | DIRECT |
| Families 57/38 glycoside transferase middle domain | 0 | DIRECT |
| Glycolipid transfer protein, GLTP | 0 | DIRECT |
| Elafin-like | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| VPS9 domain | 0 | DIRECT |
| Cytochrome c | 0 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0 | DIRECT |
| GroEL apical domain-like | 0 | DIRECT |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | DIRECT |
| JAB1/MPN domain | 0 | DIRECT |
| ThrRS/AlaRS common domain | 0 | DIRECT |
| CO dehydrogenase ISP C-domain like | 0 | DIRECT |
| Carbon-nitrogen hydrolase | 0 | DIRECT |
| Rudiment single hybrid motif | 0 | DIRECT |
| Tricorn protease domain 2 | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| DEATH domain | 0 | DIRECT |
| ARID-like | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| Terpenoid synthases | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| Complement control module/SCR domain | 0 | DIRECT |
| Molybdenum cofactor-binding domain | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| TGS-like | 0 | DIRECT |
| Radical SAM enzymes | 0 | DIRECT |
| Sec7 domain | 0 | DIRECT |
| LDH C-terminal domain-like | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| PurM C-terminal domain-like | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| Nucleoside diphosphate kinase, NDK | 0 | DIRECT |
| PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | DIRECT |
| AN1-like Zinc finger | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| HSP20-like chaperones | 0 | DIRECT |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
| Pepsin inhibitor-3 | 0 | DIRECT |
| PLC-like phosphodiesterases | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Troponin coil-coiled subunits | 0 | DIRECT |
| Integrin alpha N-terminal domain | 0 | DIRECT |
| PGBD-like | 0 | DIRECT |
| Cullin repeat-like | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Band 7/SPFH domain | 0 | DIRECT |
| PEBP-like | 0 | DIRECT |
| Doublecortin (DC) | 0 | DIRECT |
| PHM/PNGase F | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| Insulin-like | 0 | DIRECT |
| Hypothetical protein c14orf129, hspc210 | 0 | DIRECT |
| Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
| Hedgehog/intein (Hint) domain | 0 | DIRECT |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
| Heme-dependent catalase-like | 0 | DIRECT |
| Nucleotidyltransferase | 0 | DIRECT |
| ISP domain | 0 | DIRECT |
| Carboxypeptidase regulatory domain-like | 0 | DIRECT |
| Ferritin-like | 0 | DIRECT |
| L-aspartase-like | 0 | DIRECT |
| GAS2 domain-like | 0 | DIRECT |
| PreATP-grasp domain | 0 | DIRECT |
| WGR domain-like | 0 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
| P-loop containing nucleoside triphosphate hydrolases | 0.000000128 | DIRECT |
| PH domain-like | 0.0000436 | DIRECT |
| Histone-fold | 0.0001106 | DIRECT |
| Protein kinase-like (PK-like) | 0.003581 | INHERITED FROM: chemical response variant || octanol chemotaxis defective || alkaline pH chemotaxis variant || protein expression variant || positive chemotaxis variant || egg laying response to food variant || protein subcellular localization variant || anoxia resistant || mechanosensation variant || organism osmostic stress hypersensitive || life span variant || second messenger mediated signaling variant || aldicarb response variant || colchicine resistant || drug induced gene expression variant || metal response variant || protein phosphorylation variant || metabolic pathway variant || lipid synthesis increased || mid larval arrest || conflicting sensory integration variant || pathogen induced gene expression variant || organism environmental stimulus response variant || protein phosphorylation reduced || copper response variant || kinase activity reduced |
| TPR-like | 0.01729 | INHERITED FROM: positive chemotaxis defective || light body touch resistant || dauer defective || ivermectin response variant || antihelmintic response variant || ivermectin resistant || chemotaxis variant || associative learning variant |
| Periplasmic binding protein-like I | 0.01738 | INHERITED FROM: chemosensory response variant || chemical response variant || carbon dioxide avoidance variant || AWC odorant chemotaxis variant || memory retention defective || diacetyl chemotaxis variant || AWC odorant chemotaxis defective || alkaline pH chemotaxis variant || positive chemotaxis variant || mechanosensation variant || iodide chemotaxis defective || iodide chemotaxis variant || second messenger mediated signaling variant || bromide chemotaxis defective || lithium chemotaxis defective || chemotaxis variant || aqueous chemosensory response variant || magnesium chemotaxis defective || aqueous positive chemotaxis variant || organism environmental stimulus response variant || bromide chemotaxis variant || benzaldehyde chemotaxis variant |
| PapD-like | 0.02572 | INHERITED FROM: dauer metabolism variant || fat content variant || dauer lifespan variant || dauer lifespan extended || developmental growth variant || lipid metabolism variant || larval arrest || larval growth variant || slow growth |
| ARM repeat | 0.03465 | INHERITED FROM: protein expression variant || organism metabolism processing variant || sick || organism hypersensitive ionizing radiation || gene expression variant || pattern of transgene expression variant |
| SH2 domain | 0.04055 | INHERITED FROM: aldicarb resistant || level of protein expression variant || protein expression variant || protein expression reduced || acetylcholinesterase inhibitor resistant |
| "Winged helix" DNA-binding domain | 0.0424 | INHERITED FROM: protein aggregation variant || shortened life span || anesthetic response variant || chemical hypersensitive || protein aggregation induced behavior variant || protein expression increased || life span variant || protein protein interaction variant || organism metabolism processing variant || organism hypertonic lethality increased || paraquat hypersensitive || germline transgene silencing variant || spontaneous mutation rate increased || growth rate variant |
| PDZ domain-like | 0.04776 | INHERITED FROM: protein expression variant || drug resistant || aldicarb response variant || acetylcholinesterase inhibitor response variant |
| Homeodomain-like | 0.05029 | INHERITED FROM: carbon dioxide avoidance variant || level of transgene expression variant || protein degradation variant || inhibitor of serotonin uptake variant || carbon dioxide response variant || adrenergic receptor antagonist response variant || organism metabolism processing variant || imipramine resistant || ectopic expression transgene || growth rate variant || egg laying imipramine resistant || sexually dimorphic physiology variant |
| WD40 repeat-like | 0.05999 | INHERITED FROM: protein aggregation variant || protein aggregation induced behavior variant || antimicrobial gene expression variant || protein protein interaction variant || early larval arrest || organism metabolism processing variant || osmotic avoidance variant || late larval arrest |
| Nucleic acid-binding proteins | 0.06074 | INHERITED FROM: hypoxia resistant || nonsense mRNA accumulation || hydroxyurea response variant || mRNA surveillance defective || sick || hydroxyurea hypersensitive |
| Acetyl-CoA synthetase-like | 0.06265 | INHERITED FROM: lipid metabolism variant |
| Calponin-homology domain, CH-domain | 0.06265 | INHERITED FROM: protein expression variant |
| Cyclin-like | 0.06946 | INHERITED FROM: protein phosphorylation variant || protein phosphorylation reduced |
| CCCH zinc finger | 0.07711 | INHERITED FROM: mRNA expression ectopic || transgene expression variant || ectopic expression transgene || gene expression variant || RNA metabolism variant |
| EGF/Laminin | 0.078 | INHERITED FROM: octanol chemotaxis defective || odorant negative chemotaxis defective || octanol chemotaxis variant || negative chemotaxis variant |
| Translation proteins | 0.09511 | INHERITED FROM: protein aggregation variant || mRNA levels increased || transgene expression variant || protein protein interaction variant || organism metabolism processing variant || sick || proteasome core activity variant || gene expression variant || protein phosphorylation increased |
| Galactose-binding domain-like | 0.09864 | INHERITED FROM: protein aggregation variant || protein protein interaction variant || protein interaction variant |
| Nucleotide cyclase | 0.1169 | INHERITED FROM: cation positive chemotaxis variant || chemosensory response variant || AWC odorant chemotaxis variant || diacetyl chemotaxis variant || AWC odorant chemotaxis defective || alkaline pH chemotaxis variant || cation positive chemotaxis defective || anion positive chemotaxis defective || positive chemotaxis variant || iodide chemotaxis defective || iodide chemotaxis variant || second messenger mediated signaling variant || bromide chemotaxis defective || carbon dioxide response variant || osmotic avoidance variant || anion positive chemotaxis variant || lithium chemotaxis defective || chemotaxis variant || magnesium chemotaxis defective || organism environmental stimulus response variant || bromide chemotaxis variant |
| HLH, helix-loop-helix DNA-binding domain | 0.1169 | INHERITED FROM: lysine chemotaxis defective || aqueous positive chemotaxis defective || RNA expression variant || gene expression level reduced || organism metabolism processing variant || ectopic expression transgene || hypoxia response variant || pathogen resistance increased || fungal resistance increased |
| SMAD/FHA domain | 0.1172 | INHERITED FROM: aldicarb response variant |
| Acid proteases | 0.1172 | INHERITED FROM: protein aggregation variant || osmotic integrity variant || transgene subcellular localization variant || transgene expression variant || protein protein interaction variant || organism metabolism processing variant || gene expression variant || protein interaction variant || hypoosmotic shock hypersensitive |
| Calcium ATPase, transmembrane domain M | 0.13 | INHERITED FROM: nicotine hypersensitive || drug hypersensitive || organism environmental stimulus response variant || lipid composition variant |
| Regulator of G-protein signaling, RGS | 0.144 | INHERITED FROM: mechanosensation variant || negative chemotaxis variant || chemotaxis variant |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.144 | INHERITED FROM: nicotine hypersensitive || drug hypersensitive || organism environmental stimulus response variant || lipid composition variant |
| SH3-domain | 0.1538 | INHERITED FROM: protein expression variant || aldicarb response variant || protein expression reduced |
| E set domains | 0.1562 | INHERITED FROM: paraquat hypersensitive |
| Calcium ATPase, transduction domain A | 0.16 | INHERITED FROM: nicotine hypersensitive || drug hypersensitive || organism environmental stimulus response variant |
| Quinoprotein alcohol dehydrogenase-like | 0.1771 | INHERITED FROM: protein degradation variant || mRNA levels increased || drug response variant || mid larval arrest || hypoxia response variant || L2 arrest |
| Ankyrin repeat | 0.1884 | INHERITED FROM: chemosensory response variant || octanol chemotaxis defective || odorant negative chemotaxis defective || mechanosensation variant || octanol chemotaxis variant || organism stress response variant || chemotaxis variant || organism heat response variant |
| Multidrug efflux transporter AcrB transmembrane domain | 0.1915 | INHERITED FROM: positive chemotaxis defective || odorant positive chemotaxis defective || odorant chemosensory response variant || chemotaxis variant || egg integrity defective early emb || embryo osmotic integrity defective early emb |
| DBL homology domain (DH-domain) | 0.1962 | INHERITED FROM: aldicarb response variant || bacterially unswollen || organism pathogen response variant || organism environmental stimulus response variant || pathogen resistance increased |
| ClpP/crotonase | 0.2174 | INHERITED FROM: level of transgene expression variant || fat content variant || lipid metabolism variant |
| HMG-box | 0.2174 | INHERITED FROM: transgene expression variant || maintenance of gene silencing variant |
| (Trans)glycosidases | 0.2187 | INHERITED FROM: pathogen susceptibility increased || pathogen load variant |
| Cytochrome P450 | 0.2187 | INHERITED FROM: cadmium response variant || metal response variant |
| PLP-dependent transferases | 0.244 | INHERITED FROM: carbon dioxide avoidance variant |
| POZ domain | 0.2575 | INHERITED FROM: chemical hypersensitive || protein aggregation induced behavior variant || L1 arrest || early larval arrest || resistant to protein aggregation induced paralysis |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.2661 | INHERITED FROM: fat content variant || lipid metabolism variant |
| Bromodomain | 0.2661 | INHERITED FROM: anesthetic response variant || organism UV response variant || acute functional tolerance to alcohol defective || sick || organism UV hypersensitive || anesthetic resistant || ethanol resistant || drug adaptation variant |
| RNA-binding domain, RBD | 0.2674 | INHERITED FROM: starvation induced apoptosis variant || RNA expression variant || innate immune response variant || antimicrobial gene expression variant || organism metabolism processing variant || sick || alternative splicing variant || mRNA export variant || RNA processing variant || maintenance of gene silencing variant || no induction of antimicrobial peptide expression after infection |
| Cysteine proteinases | 0.2721 | INHERITED FROM: osmotic integrity variant || protein protein interaction variant || organism metabolism processing variant || protein interaction variant || paraquat hypersensitive || pattern of transgene expression variant || hypoosmotic shock hypersensitive |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.2739 | INHERITED FROM: organism osmotic stress response variant |
| RNI-like | 0.283 | INHERITED FROM: resistant to protein aggregation induced paralysis |
| SNARE-like | 0.2938 | INHERITED FROM: aldicarb resistant || transgene subcellular localization variant || transgene expression variant || aldicarb response variant || organism metabolism processing variant || sick || protein metabolism variant || acetylcholinesterase inhibitor response variant || acetylcholinesterase inhibitor resistant || gene expression variant || pattern of transgene expression variant |
| ABC transporter transmembrane region | 0.2963 | INHERITED FROM: cadmium response variant || RNAi response variant || metal response variant || organism environmental stimulus response variant || colchicine hypersensitive |
| Lipocalins | 0.3053 | INHERITED FROM: fat content variant || lipid metabolism variant || fat content increased || paraquat hypersensitive |
| Translation proteins SH3-like domain | 0.3588 | INHERITED FROM: protein aggregation variant || transgene expression variant || protein protein interaction variant || early larval arrest || organism metabolism processing variant || gene expression variant |
| Cation efflux protein transmembrane domain-like | 0.3588 | INHERITED FROM: cadmium hypersensitive || manganese response variant || metal response variant || manganese toxicity resistant |
| Nicotinic receptor ligand binding domain-like | 0.371 | INHERITED FROM: chemical response variant || slowing response on food variant || sodium chloride chemotaxis variant || nicotine resistant || mechanosensation variant || DMPP response variant || drug response variant || cholinergic agonist resistant || antihelmintic response variant || selenium response variant || aqueous chemosensory response variant || organism environmental stimulus response variant || hypoosmotic shock hypersensitive |
| Ubiquitin-like | 0.3875 | INHERITED FROM: heteroplasmy || protein aggregation variant || protein protein interaction variant || organism metabolism processing variant || protein interaction variant |
| Cysteine-rich domain | 0.4011 | INHERITED FROM: odorant positive chemotaxis variant || positive chemotaxis variant || protein subcellular localization variant || antimicrobial gene expression variant || aldicarb response variant || organism metabolism processing variant || bacterially unswollen || drug induced gene expression variant || acetylcholinesterase inhibitor response variant || odorant chemosensory response variant || organism pathogen response variant |
| FKBP-like | 0.407 | INHERITED FROM: protein aggregation variant || transgene subcellular localization variant || protein protein interaction variant || protein interaction variant || pattern of transgene expression variant |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.4079 | INHERITED FROM: chemical response variant || positive chemotaxis variant || slowing response on food variant || sodium chloride chemotaxis variant || nicotine resistant || mechanosensation variant || DMPP response variant || drug response variant || cholinergic agonist resistant || antihelmintic response variant || selenium response variant || aqueous chemosensory response variant || organism environmental stimulus response variant || hypoosmotic shock hypersensitive |
| Class II aaRS and biotin synthetases | 0.4666 | INHERITED FROM: oxygen response variant || transgene expression variant || hypoxia resistant || organism metabolism processing variant || gene expression variant || hypoxia response variant || organism environmental stimulus response variant |
| Hect, E3 ligase catalytic domain | 0.4795 | INHERITED FROM: protein aggregation variant || transgene subcellular localization variant || protein aggregation induced behavior variant || transgene expression variant || protein protein interaction variant || organism metabolism processing variant || gene expression variant || protein interaction variant || pattern of transgene expression variant || organism environmental stimulus response variant |
| PRTase-like | 0.4795 | INHERITED FROM: drug resistant || Fluorouracil resistant |
| DHS-like NAD/FAD-binding domain | 0.4795 | INHERITED FROM: protein acetylation variant || protein modification variant |
| Myosin rod fragments | 0.4795 | INHERITED FROM: drug resistant |
| BRCT domain | 0.5005 | INHERITED FROM: organism ionizing radiation response variant |
| FYVE/PHD zinc finger | 0.5198 | INHERITED FROM: organism UV response variant || protein modification variant || ectopic expression transgene || organism UV hypersensitive || protein methylation variant |
| Ribosomal protein S5 domain 2-like | 0.5232 | INHERITED FROM: transgene expression variant || early larval arrest |
| Calpain large subunit, middle domain (domain III) | 0.5285 | INHERITED FROM: protein degradation variant || protein metabolism variant || metabolic pathway variant |
| Riboflavin synthase domain-like | 0.5285 | INHERITED FROM: pattern protein expression variant |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.5285 | INHERITED FROM: pattern protein expression variant |
| Cystine-knot cytokines | 0.5322 | INHERITED FROM: levamisole response variant || nicotine response variant |
| WW domain | 0.5322 | INHERITED FROM: aldicarb resistant || acetylcholinesterase inhibitor resistant || maintenance of gene silencing variant |
| Sm-like ribonucleoproteins | 0.5322 | INHERITED FROM: unfolded protein response variant || protein subcellular localization variant || transgene expression variant || life span variant || sick || gene expression variant || pattern of transgene expression variant || organism heat response variant |
| FAD-linked reductases, C-terminal domain | 0.5322 | INHERITED FROM: life span variant |
| Voltage-gated potassium channels | 0.5365 | INHERITED FROM: protein degradation variant || positive chemotaxis defective || mechanosensation variant || adrenergic receptor antagonist response variant || protein metabolism variant || growth rate variant || serotonin resistant || serotonin response variant |
| Nucleotidylyl transferase | 0.5566 | INHERITED FROM: oxygen response variant || transgene expression increased || innate immune response variant || hypoxia resistant || antimicrobial gene expression variant || organism metabolism processing variant || hypoxia response variant || organism environmental stimulus response variant || paraquat resistant |
| FAD/NAD(P)-binding domain | 0.56 | INHERITED FROM: ATP levels variant || ATP levels reduced || life span variant || pesticide response variant |
| SET domain | 0.5687 | INHERITED FROM: shortened life span || protein expression variant || RNAi response variant || life span variant || protein modification variant || protein metabolism variant || metabolic pathway variant || dosage compensation variant || ectopic expression antibody || histone methylation variant || somatic transgene silencing variant || spontaneous mutation rate increased || maintenance of gene silencing variant || protein methylation variant |
| Seven-hairpin glycosidases | 0.5788 | INHERITED FROM: extended life span || protein aggregation variant || protein protein interaction variant |
| SAM/Pointed domain | 0.5816 | INHERITED FROM: aldicarb response variant |
| UBC-like | 0.5932 | INHERITED FROM: protein aggregation variant || transgene subcellular localization variant || protein protein interaction variant || organism metabolism processing variant || sick || protein interaction variant || pattern of transgene expression variant || late larval arrest |
| Multidrug resistance efflux transporter EmrE | 0.5999 | INHERITED FROM: bacterially unswollen || pathogen resistance increased |
| HAD-like | 0.6071 | INHERITED FROM: nicotine hypersensitive |
| Osmotin, thaumatin-like protein | 0.6361 | INHERITED FROM: cadmium hypersensitive || cadmium response variant || metal response variant |
| KA1-like | 0.6361 | INHERITED FROM: RNA expression variant |
| Nucleotide-binding domain | 0.6361 | INHERITED FROM: extended life span || life span variant |
| MFS general substrate transporter | 0.6675 | INHERITED FROM: organism high sodium chloride hypersensitive |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.6678 | INHERITED FROM: chemical response variant || protein expression variant || drug resistant || protein subcellular localization variant || RNAi response variant || antimicrobial gene expression variant || aging variant || drug induced gene expression variant || metabolic pathway variant || egg laying serotonin variant || organism environmental stimulus response variant || growth rate variant || nose touch variant |
| GST C-terminal domain-like | 0.6917 | INHERITED FROM: cadmium hypersensitive || enzyme activity reduced || organism stress response variant || organism heat hypersensitive || metal response variant || enzyme activity variant || organism electrophilic stress hypersensitive || organism environmental stimulus response variant |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.6968 | INHERITED FROM: level of transgene expression variant || gene expression level high || gene expression level reduced || fat content increased || SDS sensitive dauer || dauer resistance to harsh conditions variant || transgene expression reduced |
| S15/NS1 RNA-binding domain | 0.6994 | INHERITED FROM: transgene expression increased |
| 4Fe-4S ferredoxins | 0.6994 | INHERITED FROM: transgene expression increased || life span variant |
| Frizzled cysteine-rich domain | 0.6994 | INHERITED FROM: antibody staining variant || transgene expression reduced |
| Ribonuclease H-like | 0.7316 | INHERITED FROM: RNA expression variant || RNAi response variant || 21U RNA expression variant || RNAi enhanced || somatic transgene silencing variant || siRNA expression variant || maintenance of gene silencing variant |
| PAZ domain | 0.7457 | INHERITED FROM: RNA expression variant || mRNA levels increased || RNAi response variant || 21U RNA expression variant || RNAi enhanced || somatic transgene silencing variant || siRNA expression variant || maintenance of gene silencing variant |
| ADC-like | 0.7682 | INHERITED FROM: protein aggregation variant || protein protein interaction variant || protein metabolism variant || metabolic pathway variant || protein interaction variant || transgene expression reduced |
| MIT domain | 0.7682 | INHERITED FROM: protein aggregation variant || protein protein interaction variant || protein interaction variant |
| alpha/beta-Hydrolases | 0.8029 | INHERITED FROM: acetylcholinesterase reduced || acetylcholinesterase activity variant |
| Fibronectin type III | 0.8093 | INHERITED FROM: metabolic pathway variant || growth rate variant |
| Clavaminate synthase-like | 0.8449 | INHERITED FROM: life span variant || histone methylation variant || organism temperature response variant || protein methylation variant |
| EF-hand | 0.8492 | INHERITED FROM: protein aggregation variant || protein interaction variant |
| Leucine zipper domain | 0.8583 | INHERITED FROM: level of transgene expression variant || pathogen susceptibility increased || pore forming toxin response variant || mRNA expression variant || mRNA levels reduced || transgene expression reduced |
| GTPase activation domain, GAP | 0.8671 | INHERITED FROM: protein expression variant |
| UBA-like | 0.8699 | INHERITED FROM: protein aggregation variant || protein protein interaction variant |
| DNA/RNA polymerases | 0.9345 | INHERITED FROM: DNA metabolism variant || DNA repair variant |
| p53-like transcription factors | 0.9399 | INHERITED FROM: gene expression level reduced || ectopic expression transgene |
| Ribonuclease PH domain 2-like | 0.9508 | INHERITED FROM: early larval arrest |
| Thioredoxin-like | 0.9617 | INHERITED FROM: cadmium hypersensitive || enzyme activity reduced || organism stress response variant || organism heat hypersensitive || enzyme activity variant || organism electrophilic stress hypersensitive || paraquat response variant || organism environmental stimulus response variant |
| Immunoglobulin | 0.9618 | INHERITED FROM: protein degradation variant || aldicarb response variant || growth rate variant |
| Nuclear receptor ligand-binding domain | 0.973 | INHERITED FROM: level of transgene expression variant || gene expression level high || gene expression level reduced || lipid metabolism variant || fat content increased || SDS sensitive dauer || dauer resistance to harsh conditions variant || transgene expression reduced |
| Eukaryotic type KH-domain (KH-domain type I) | 0.9968 | INHERITED FROM: RNA expression variant |
| B-box zinc-binding domain | 1 | INHERITED FROM: protein aggregation variant || transgene subcellular localization variant || transgene expression variant || protein protein interaction variant || organism metabolism processing variant || gene expression variant || protein interaction variant |
| F-box domain | 1 | INHERITED FROM: resistant to protein aggregation induced paralysis |
| beta-beta-alpha zinc fingers | 1 | INHERITED FROM: inhibitor of serotonin uptake variant || organism metabolism processing variant || imipramine resistant || egg laying serotonin resistant || egg laying imipramine resistant |
| CoA-dependent acyltransferases | 1 | INHERITED FROM: lipid metabolism variant |
| Ligand-binding domain in the NO signalling and Golgi transport | 1 | INHERITED FROM: carbon dioxide avoidance variant || carbon dioxide response variant |
| Family A G protein-coupled receptor-like | 1 | INHERITED FROM: locomotion rate serotonin variant || serotonin induced pumping variant || serotonin induced fat reduction variant || male tail curling serotonin variant |
| Cyclophilin-like | 1 | INHERITED FROM: protein aggregation variant || transgene subcellular localization variant || transgene expression variant || protein protein interaction variant || gene expression variant || protein interaction variant || pattern of transgene expression variant |
| Bet v1-like | 1 | INHERITED FROM: growth rate variant |
| RING/U-box | 1 | INHERITED FROM: protein aggregation variant || transgene subcellular localization variant || transgene expression variant || protein protein interaction variant || organism metabolism processing variant || gene expression variant || protein interaction variant || pattern of transgene expression variant |
| Saposin | 1 | INHERITED FROM: level of transgene expression variant || increased pathogen survival || pathogen load variant || transgene expression reduced |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
| Outer arm dynein light chain 1 | 0 | Direct |
| Ribosomal L27 protein-like | 0 | Direct |
| DNA repair protein MutS, domain III | 0 | Direct |
| Polo-box domain | 0 | Direct |
| Kringle-like | 0 | Direct |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
| Mitochondrial carrier | 0 | Direct |
| MFPT repeat-like | 0 | Direct |
| ADP-ribosylation | 0 | Direct |
| GroEL equatorial domain-like | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| beta-lactamase/transpeptidase-like | 0 | Direct |
| ArfGap/RecO-like zinc finger | 0 | Direct |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
| Restriction endonuclease-like | 0 | Direct |
| eIF4e-like | 0 | Direct |
| Chaperone J-domain | 0 | Direct |
| Thiolase-like | 0 | Direct |
| Surp module (SWAP domain) | 0 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| Pentein | 0 | Direct |
| Subtilisin-like | 0 | Direct |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | Direct |
| MIR domain | 0 | Direct |
| Ribosomal protein L1 | 0 | Direct |
| Glutathione synthetase ATP-binding domain-like | 0 | Direct |
| RBP11-like subunits of RNA polymerase | 0 | Direct |
| Type II DNA topoisomerase | 0 | Direct |
| PABC (PABP) domain | 0 | Direct |
| Invertebrate chitin-binding proteins | 0 | Direct |
| Cadherin-like | 0 | Direct |
| Chitinase insertion domain | 0 | Direct |
| dsRNA-binding domain-like | 0 | Direct |
| Profilin (actin-binding protein) | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | Direct |
| LysM domain | 0 | Direct |
| PAP/OAS1 substrate-binding domain | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| CBD9-like | 0 | Direct |
| HCP-like | 0 | Direct |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| Class II aaRS ABD-related | 0 | Direct |
| alpha/beta knot | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
| Skp1 dimerisation domain-like | 0 | Direct |
| Cdc48 domain 2-like | 0 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
| LEM domain | 0 | Direct |
| Activating enzymes of the ubiquitin-like proteins | 0 | Direct |
| Citrate synthase | 0 | Direct |
| Heme-dependent peroxidases | 0 | Direct |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| MOSC N-terminal domain-like | 0 | Direct |
| GroES-like | 0 | Direct |
| Aldolase | 0 | Direct |
| Small-conductance potassium channel | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| lambda repressor-like DNA-binding domains | 0 | Direct |
| GAT-like domain | 0 | Direct |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | Direct |
| Ran binding protein zinc finger-like | 0 | Direct |
| Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
| Rap/Ran-GAP | 0 | Direct |
| Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
| MgtE membrane domain-like | 0 | Direct |
| FtsH protease domain-like | 0 | Direct |
| PurM N-terminal domain-like | 0 | Direct |
| Chromo domain-like | 0 | Direct |
| Tubby C-terminal domain-like | 0 | Direct |
| Annexin | 0 | Direct |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0 | Direct |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
| TK C-terminal domain-like | 0 | Direct |
| R3H domain | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| Translational machinery components | 0 | Direct |
| Tubulin nucleotide-binding domain-like | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| 2Fe-2S ferredoxin-like | 0 | Direct |
| t-snare proteins | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| Creatinase/prolidase N-terminal domain | 0 | Direct |
| Nucleoporin domain | 0 | Direct |
| Aquaporin-like | 0 | Direct |
| Galactose mutarotase-like | 0 | Direct |
| PK beta-barrel domain-like | 0 | Direct |
| SAND domain-like | 0 | Direct |
| SCP-like | 0 | Direct |
| Class I glutamine amidotransferase-like | 0 | Direct |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| Thyroglobulin type-1 domain | 0 | Direct |
| Oxysterol-binding protein-like | 0 | Direct |
| PIN domain-like | 0 | Direct |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
| Proton glutamate symport protein | 0 | Direct |
| Spectrin repeat | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| Arginase/deacetylase | 0 | Direct |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
| Tubulin C-terminal domain-like | 0 | Direct |
| YWTD domain | 0 | Direct |
| CRAL/TRIO N-terminal domain | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| Galactose oxidase, central domain | 0 | Direct |
| Clc chloride channel | 0 | Direct |
| Fibrinogen C-terminal domain-like | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Periplasmic binding protein-like II | 0 | Direct |
| Intermediate filament protein, coiled coil region | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| Integrin domains | 0 | Direct |
| GroEL-intermediate domain like | 0 | Direct |
| CAD & PB1 domains | 0 | Direct |
| ENTH/VHS domain | 0 | Direct |
| SIS domain | 0 | Direct |
| Composite domain of metallo-dependent hydrolases | 0 | Direct |
| S-adenosylmethionine synthetase | 0 | Direct |
| Purine and uridine phosphorylases | 0 | Direct |
| PYP-like sensor domain (PAS domain) | 0 | Direct |
| Second domain of FERM | 0 | Direct |
| Ribokinase-like | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| Ribosomal proteins S24e, L23 and L15e | 0 | Direct |
| Sec63 N-terminal domain-like | 0 | Direct |
| Cystatin/monellin | 0 | Direct |
| L30e-like | 0 | Direct |
| Actin-like ATPase domain | 0 | Direct |
| PUA domain-like | 0 | Direct |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | Direct |
| Protease propeptides/inhibitors | 0 | Direct |
| Phoshotransferase/anion transport protein | 0 | Direct |
| Carbohydrate phosphatase | 0 | Direct |
| GYF domain | 0 | Direct |
| PEP carboxykinase-like | 0 | Direct |
| Ribosomal protein S10 | 0 | Direct |
| Zn-binding ribosomal proteins | 0 | Direct |
| Tim10-like | 0 | Direct |
| YbiA-like | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| Ribosomal protein L10-like | 0 | Direct |
| Diaminopimelate epimerase-like | 0 | Direct |
| cAMP-binding domain-like | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| Carbonic anhydrase | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| SAICAR synthase-like | 0 | Direct |
| FF domain | 0 | Direct |
| Putative DNA-binding domain | 0 | Direct |
| HSP40/DnaJ peptide-binding domain | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| BEACH domain | 0 | Direct |
| alpha-catenin/vinculin-like | 0 | Direct |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| Hormone receptor domain | 0 | Direct |
| Blood coagulation inhibitor (disintegrin) | 0 | Direct |
| WWE domain | 0 | Direct |
| Single hybrid motif | 0 | Direct |
| Acyl-CoA dehydrogenase NM domain-like | 0 | Direct |
| Families 57/38 glycoside transferase middle domain | 0 | Direct |
| Glycolipid transfer protein, GLTP | 0 | Direct |
| Elafin-like | 0 | Direct |
| Nop domain | 0 | Direct |
| VPS9 domain | 0 | Direct |
| Cytochrome c | 0 | Direct |
| Transducin (alpha subunit), insertion domain | 0 | Direct |
| GroEL apical domain-like | 0 | Direct |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | Direct |
| JAB1/MPN domain | 0 | Direct |
| ThrRS/AlaRS common domain | 0 | Direct |
| CO dehydrogenase ISP C-domain like | 0 | Direct |
| Carbon-nitrogen hydrolase | 0 | Direct |
| Rudiment single hybrid motif | 0 | Direct |
| Tricorn protease domain 2 | 0 | Direct |
| SPOC domain-like | 0 | Direct |
| DEATH domain | 0 | Direct |
| ARID-like | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| Terpenoid synthases | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| Complement control module/SCR domain | 0 | Direct |
| Molybdenum cofactor-binding domain | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
| TGS-like | 0 | Direct |
| Radical SAM enzymes | 0 | Direct |
| Sec7 domain | 0 | Direct |
| LDH C-terminal domain-like | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| PurM C-terminal domain-like | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| Nucleoside diphosphate kinase, NDK | 0 | Direct |
| PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | Direct |
| AN1-like Zinc finger | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| HSP20-like chaperones | 0 | Direct |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
| Pepsin inhibitor-3 | 0 | Direct |
| PLC-like phosphodiesterases | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Troponin coil-coiled subunits | 0 | Direct |
| Integrin alpha N-terminal domain | 0 | Direct |
| PGBD-like | 0 | Direct |
| Cullin repeat-like | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Band 7/SPFH domain | 0 | Direct |
| PEBP-like | 0 | Direct |
| Doublecortin (DC) | 0 | Direct |
| PHM/PNGase F | 0 | Direct |
| ALDH-like | 0 | Direct |
| Insulin-like | 0 | Direct |
| Hypothetical protein c14orf129, hspc210 | 0 | Direct |
| Cation efflux protein cytoplasmic domain-like | 0 | Direct |
| Hedgehog/intein (Hint) domain | 0 | Direct |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
| Heme-dependent catalase-like | 0 | Direct |
| Nucleotidyltransferase | 0 | Direct |
| ISP domain | 0 | Direct |
| Carboxypeptidase regulatory domain-like | 0 | Direct |
| Ferritin-like | 0 | Direct |
| L-aspartase-like | 0 | Direct |
| GAS2 domain-like | 0 | Direct |
| PreATP-grasp domain | 0 | Direct |
| WGR domain-like | 0 | Direct |
| Bacterial exopeptidase dimerisation domain | 0 | Direct |
| P-loop containing nucleoside triphosphate hydrolases | 0.000000128 | Direct |
| PH domain-like | 0.0000436 | Direct |
| Histone-fold | 0.0001106 | Direct |
| Protein kinase-like (PK-like) | 0.003581 | Inherited |
| TPR-like | 0.01729 | Inherited |
| Periplasmic binding protein-like I | 0.01738 | Inherited |
| PapD-like | 0.02572 | Inherited |
| ARM repeat | 0.03465 | Inherited |
| SH2 domain | 0.04055 | Inherited |
| "Winged helix" DNA-binding domain | 0.0424 | Inherited |
| PDZ domain-like | 0.04776 | Inherited |
| Homeodomain-like | 0.05029 | Inherited |
| WD40 repeat-like | 0.05999 | Inherited |
| Nucleic acid-binding proteins | 0.06074 | Inherited |
| Acetyl-CoA synthetase-like | 0.06265 | Inherited |
| Calponin-homology domain, CH-domain | 0.06265 | Inherited |
| Cyclin-like | 0.06946 | Inherited |
| CCCH zinc finger | 0.07711 | Inherited |
| EGF/Laminin | 0.078 | Inherited |
| Translation proteins | 0.09511 | Inherited |
| Galactose-binding domain-like | 0.09864 | Inherited |
| Nucleotide cyclase | 0.1169 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.1169 | Inherited |
| SMAD/FHA domain | 0.1172 | Inherited |
| Acid proteases | 0.1172 | Inherited |
| Calcium ATPase, transmembrane domain M | 0.13 | Inherited |
| Regulator of G-protein signaling, RGS | 0.144 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.144 | Inherited |
| SH3-domain | 0.1538 | Inherited |
| E set domains | 0.1562 | Inherited |
| Calcium ATPase, transduction domain A | 0.16 | Inherited |
| Quinoprotein alcohol dehydrogenase-like | 0.1771 | Inherited |
| Ankyrin repeat | 0.1884 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.1915 | Inherited |
| DBL homology domain (DH-domain) | 0.1962 | Inherited |
| ClpP/crotonase | 0.2174 | Inherited |
| HMG-box | 0.2174 | Inherited |
| (Trans)glycosidases | 0.2187 | Inherited |
| Cytochrome P450 | 0.2187 | Inherited |
| PLP-dependent transferases | 0.244 | Inherited |
| POZ domain | 0.2575 | Inherited |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.2661 | Inherited |
| Bromodomain | 0.2661 | Inherited |
| RNA-binding domain, RBD | 0.2674 | Inherited |
| Cysteine proteinases | 0.2721 | Inherited |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.2739 | Inherited |
| RNI-like | 0.283 | Inherited |
| SNARE-like | 0.2938 | Inherited |
| ABC transporter transmembrane region | 0.2963 | Inherited |
| Lipocalins | 0.3053 | Inherited |
| Translation proteins SH3-like domain | 0.3588 | Inherited |
| Cation efflux protein transmembrane domain-like | 0.3588 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.371 | Inherited |
| Ubiquitin-like | 0.3875 | Inherited |
| Cysteine-rich domain | 0.4011 | Inherited |
| FKBP-like | 0.407 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.4079 | Inherited |
| Class II aaRS and biotin synthetases | 0.4666 | Inherited |
| Hect, E3 ligase catalytic domain | 0.4795 | Inherited |
| PRTase-like | 0.4795 | Inherited |
| DHS-like NAD/FAD-binding domain | 0.4795 | Inherited |
| Myosin rod fragments | 0.4795 | Inherited |
| BRCT domain | 0.5005 | Inherited |
| FYVE/PHD zinc finger | 0.5198 | Inherited |
| Ribosomal protein S5 domain 2-like | 0.5232 | Inherited |
| Calpain large subunit, middle domain (domain III) | 0.5285 | Inherited |
| Riboflavin synthase domain-like | 0.5285 | Inherited |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.5285 | Inherited |
| Cystine-knot cytokines | 0.5322 | Inherited |
| WW domain | 0.5322 | Inherited |
| Sm-like ribonucleoproteins | 0.5322 | Inherited |
| FAD-linked reductases, C-terminal domain | 0.5322 | Inherited |
| Voltage-gated potassium channels | 0.5365 | Inherited |
| Nucleotidylyl transferase | 0.5566 | Inherited |
| FAD/NAD(P)-binding domain | 0.56 | Inherited |
| SET domain | 0.5687 | Inherited |
| Seven-hairpin glycosidases | 0.5788 | Inherited |
| SAM/Pointed domain | 0.5816 | Inherited |
| UBC-like | 0.5932 | Inherited |
| Multidrug resistance efflux transporter EmrE | 0.5999 | Inherited |
| HAD-like | 0.6071 | Inherited |
| Osmotin, thaumatin-like protein | 0.6361 | Inherited |
| KA1-like | 0.6361 | Inherited |
| Nucleotide-binding domain | 0.6361 | Inherited |
| MFS general substrate transporter | 0.6675 | Inherited |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.6678 | Inherited |
| GST C-terminal domain-like | 0.6917 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.6968 | Inherited |
| S15/NS1 RNA-binding domain | 0.6994 | Inherited |
| 4Fe-4S ferredoxins | 0.6994 | Inherited |
| Frizzled cysteine-rich domain | 0.6994 | Inherited |
| Ribonuclease H-like | 0.7316 | Inherited |
| PAZ domain | 0.7457 | Inherited |
| ADC-like | 0.7682 | Inherited |
| MIT domain | 0.7682 | Inherited |
| alpha/beta-Hydrolases | 0.8029 | Inherited |
| Fibronectin type III | 0.8093 | Inherited |
| Clavaminate synthase-like | 0.8449 | Inherited |
| EF-hand | 0.8492 | Inherited |
| Leucine zipper domain | 0.8583 | Inherited |
| GTPase activation domain, GAP | 0.8671 | Inherited |
| UBA-like | 0.8699 | Inherited |
| DNA/RNA polymerases | 0.9345 | Inherited |
| p53-like transcription factors | 0.9399 | Inherited |
| Ribonuclease PH domain 2-like | 0.9508 | Inherited |
| Thioredoxin-like | 0.9617 | Inherited |
| Immunoglobulin | 0.9618 | Inherited |
| Nuclear receptor ligand-binding domain | 0.973 | Inherited |
| Eukaryotic type KH-domain (KH-domain type I) | 0.9968 | Inherited |
| B-box zinc-binding domain | 1 | Inherited |
| F-box domain | 1 | Inherited |
| beta-beta-alpha zinc fingers | 1 | Inherited |
| CoA-dependent acyltransferases | 1 | Inherited |
| Ligand-binding domain in the NO signalling and Golgi transport | 1 | Inherited |
| Family A G protein-coupled receptor-like | 1 | Inherited |
| Cyclophilin-like | 1 | Inherited |
| Bet v1-like | 1 | Inherited |
| RING/U-box | 1 | Inherited |
| Saposin | 1 | Inherited |
(show details)
Supra-domains annotated to this WP term (Not in SPWP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
141673,50800
141673 - MOSC N-terminal domain-like
50800 - PK beta-barrel domain-like | 0 | DIRECT |
50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | DIRECT |
57889,48350
57889 - Cysteine-rich domain
48350 - GTPase activation domain, GAP | 0 | DIRECT |
54897,53187
54897 - Protease propeptides/inhibitors
53187 - Zn-dependent exopeptidases | 0 | DIRECT |
141739,141739
141739 - MFPT repeat-like
141739 - MFPT repeat-like | 0 | DIRECT |
53187,55031
53187 - Zn-dependent exopeptidases
55031 - Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
57414,57414
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like | 0 | DIRECT |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | DIRECT |
81383,52047
81383 - F-box domain
52047 - RNI-like | 0 | DIRECT |
57889,50729
57889 - Cysteine-rich domain
50729 - PH domain-like | 0 | DIRECT |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | DIRECT |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | DIRECT |
47741,56176
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like | 0 | DIRECT |
81631,55003
81631 - PAP/OAS1 substrate-binding domain
55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | DIRECT |
53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | DIRECT |
57756,50630
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases | 0 | DIRECT |
53474,53474
53474 - alpha/beta-Hydrolases
53474 - alpha/beta-Hydrolases | 0 | DIRECT |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | DIRECT |
48403,52151
48403 - Ankyrin repeat
52151 - FabD/lysophospholipase-like | 0 | DIRECT |
101690,53098
101690 - PAZ domain
53098 - Ribonuclease H-like | 0 | DIRECT |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
53901,53901
53901 - Thiolase-like
53901 - Thiolase-like | 0 | DIRECT |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | DIRECT |
51971,54373
51971 - Nucleotide-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0 | DIRECT |
161111,160240
161111 - Cation efflux protein transmembrane domain-like
160240 - Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
51735,56327
51735 - NAD(P)-binding Rossmann-fold domains
56327 - LDH C-terminal domain-like | 0 | DIRECT |
51735,55347
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | DIRECT |
56601,48403
56601 - beta-lactamase/transpeptidase-like
48403 - Ankyrin repeat | 0 | DIRECT |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0 | DIRECT |
56059,52210
56059 - Glutathione synthetase ATP-binding domain-like
52210 - Succinyl-CoA synthetase domains | 0 | DIRECT |
54495,46934
54495 - UBC-like
46934 - UBA-like | 0 | DIRECT |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | DIRECT |
48431,56968
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
47576,47576
47576 - Calponin-homology domain, CH-domain
47576 - Calponin-homology domain, CH-domain | 0 | DIRECT |
57756,57756
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains | 0 | DIRECT |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
82615,82615
82615 - Polo-box domain
82615 - Polo-box domain | 0 | DIRECT |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0 | DIRECT |
81301,81631
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain | 0 | DIRECT |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
57863,48403
57863 - ArfGap/RecO-like zinc finger
48403 - Ankyrin repeat | 0 | DIRECT |
52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0 | DIRECT |
57196,63825
57196 - EGF/Laminin
63825 - YWTD domain | 0 | DIRECT |
57903,82199
57903 - FYVE/PHD zinc finger
82199 - SET domain | 0 | DIRECT |
55326,56042
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like | 0 | DIRECT |
51735,50129
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | DIRECT |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0 | DIRECT |
54695,81382
54695 - POZ domain
81382 - Skp1 dimerisation domain-like | 0 | DIRECT |
64356,49447
64356 - SNARE-like
49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
81324,53850
81324 - Voltage-gated potassium channels
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
54665,56003
54665 - CO dehydrogenase molybdoprotein N-domain-like
56003 - Molybdenum cofactor-binding domain | 0 | DIRECT |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | DIRECT |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
56112,48371
56112 - Protein kinase-like (PK-like)
48371 - ARM repeat | 0 | DIRECT |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | DIRECT |
53187,49464
53187 - Zn-dependent exopeptidases
49464 - Carboxypeptidase regulatory domain-like | 0 | DIRECT |
81698,81698
81698 - FF domain
81698 - FF domain | 0 | DIRECT |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | DIRECT |
57362,57362
57362 - BPTI-like
57362 - BPTI-like | 0 | DIRECT |
57938,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
52540,90123
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0 | DIRECT |
161093,161093
161093 - MgtE membrane domain-like
161093 - MgtE membrane domain-like | 0 | DIRECT |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0 | DIRECT |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
81333,81333
81333 - F1F0 ATP synthase subunit C
81333 - F1F0 ATP synthase subunit C | 0 | DIRECT |
54292,47741
54292 - 2Fe-2S ferredoxin-like
47741 - CO dehydrogenase ISP C-domain like | 0 | DIRECT |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | DIRECT |
52283,51735
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
88713,88688
88713 - Glycoside hydrolase/deacetylase
88688 - Families 57/38 glycoside transferase middle domain | 0 | DIRECT |
55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | DIRECT |
81383,50978
81383 - F-box domain
50978 - WD40 repeat-like | 0 | DIRECT |
51905,56425
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
56672,100879
56672 - DNA/RNA polymerases
100879 - Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
68923,53795
68923 - PEP carboxykinase N-terminal domain
53795 - PEP carboxykinase-like | 0 | DIRECT |
57850,117839
57850 - RING/U-box
117839 - WWE domain | 0 | DIRECT |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0 | DIRECT |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0 | DIRECT |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0 | DIRECT |
54236,54236
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0 | DIRECT |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | DIRECT |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0 | DIRECT |
144232,82199
144232 - HIT/MYND zinc finger-like
82199 - SET domain | 0 | DIRECT |
50044,52540
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
49742,49742
49742 - PHM/PNGase F
49742 - PHM/PNGase F | 0 | DIRECT |
52540,81271
52540 - P-loop containing nucleoside triphosphate hydrolases
81271 - TGS-like | 0 | DIRECT |
50156,50044
50156 - PDZ domain-like
50044 - SH3-domain | 0 | DIRECT |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | DIRECT |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
46938,52087
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain | 0 | DIRECT |
56968,48431
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
55394,55394
55394 - Bactericidal permeability-increasing protein, BPI
55394 - Bactericidal permeability-increasing protein, BPI | 0 | DIRECT |
54211,55060
54211 - Ribosomal protein S5 domain 2-like
55060 - GHMP Kinase, C-terminal domain | 0 | DIRECT |
52113,52113
52113 - BRCT domain
52113 - BRCT domain | 0 | DIRECT |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0 | DIRECT |
51445,51445
51445 - (Trans)glycosidases
51445 - (Trans)glycosidases | 0 | DIRECT |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | DIRECT |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
81324,81327
81324 - Voltage-gated potassium channels
81327 - Small-conductance potassium channel | 0 | DIRECT |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | DIRECT |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | DIRECT |
52047,48371
52047 - RNI-like
48371 - ARM repeat | 0 | DIRECT |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | DIRECT |
46785,46785
46785 - "Winged helix" DNA-binding domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0 | DIRECT |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0 | DIRECT |
47473,103506
47473 - EF-hand
103506 - Mitochondrial carrier | 0 | DIRECT |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | DIRECT |
52540,140990
52540 - P-loop containing nucleoside triphosphate hydrolases
140990 - FtsH protease domain-like | 0 | DIRECT |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | DIRECT |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
55920,46785
55920 - Creatinase/aminopeptidase
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
49493,49493
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
53738,55957
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
50044,50044
50044 - SH3-domain
50044 - SH3-domain | 0 | DIRECT |
74650,51445
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases | 0 | DIRECT |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
51556,51338
51556 - Metallo-dependent hydrolases
51338 - Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
47587,56399
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | DIRECT |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0 | DIRECT |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0 | DIRECT |
48464,89009
48464 - ENTH/VHS domain
89009 - GAT-like domain | 0 | DIRECT |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0 | DIRECT |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0 | DIRECT |
81324,81296
81324 - Voltage-gated potassium channels
81296 - E set domains | 0 | DIRECT |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
51445,54556
51445 - (Trans)glycosidases
54556 - Chitinase insertion domain | 0 | DIRECT |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
50978,50998
50978 - WD40 repeat-like
50998 - Quinoprotein alcohol dehydrogenase-like | 0 | DIRECT |
51338,51556
51338 - Composite domain of metallo-dependent hydrolases
51556 - Metallo-dependent hydrolases | 0 | DIRECT |
48425,50729
48425 - Sec7 domain
50729 - PH domain-like | 0 | DIRECT |
56112,82615
56112 - Protein kinase-like (PK-like)
82615 - Polo-box domain | 0 | DIRECT |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | DIRECT |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
52047,52047
52047 - RNI-like
52047 - RNI-like | 0 | DIRECT |
57625,57625
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins | 0 | DIRECT |
51445,51011
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0 | DIRECT |
52440,56059
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | DIRECT |
55729,55729
55729 - Acyl-CoA N-acyltransferases (Nat)
55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | DIRECT |
103473,103473
103473 - MFS general substrate transporter
103473 - MFS general substrate transporter | 0 | DIRECT |
54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | DIRECT |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
47203,47203
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | DIRECT |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
48179,48179
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.00252 | INHERITED FROM: dauer lifespan variant || organism UV response variant || dauer lifespan extended || organism stress response variant || sick || organism UV hypersensitive || organism environmental stimulus response variant || slow growth |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.01561 | INHERITED FROM: aldicarb resistant || acetylcholinesterase inhibitor resistant |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.1172 | INHERITED FROM: chemical response variant || positive chemotaxis defective || dauer defective || ivermectin response variant || antihelmintic response variant || ivermectin resistant || gene expression variant || chemotaxis variant || aqueous chemosensory response variant || pattern of transgene expression variant || organism environmental stimulus response variant |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0.144 | INHERITED FROM: nicotine hypersensitive || drug hypersensitive || organism environmental stimulus response variant || lipid composition variant |
56112,55073
56112 - Protein kinase-like (PK-like)
55073 - Nucleotide cyclase | 0.144 | INHERITED FROM: cation positive chemotaxis variant || chemosensory response variant || chemical response variant || AWC odorant chemotaxis variant || AWC odorant chemotaxis defective || alkaline pH chemotaxis variant || cation positive chemotaxis defective || anion positive chemotaxis defective || positive chemotaxis variant || iodide chemotaxis defective || iodide chemotaxis variant || bromide chemotaxis defective || anion positive chemotaxis variant || lithium chemotaxis defective || chemotaxis variant || aqueous chemosensory response variant || magnesium chemotaxis defective || organism environmental stimulus response variant || bromide chemotaxis variant || benzaldehyde chemotaxis variant |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0.1748 | INHERITED FROM: cadmium hypersensitive |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0.2174 | INHERITED FROM: protein aggregation variant || mRNA levels increased || transgene expression variant || protein protein interaction variant || protein modification variant || proteasome core activity variant || mRNA levels reduced || protein phosphorylation increased |
56436,49854
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain | 0.2625 | INHERITED FROM: cadmium hypersensitive || cadmium response variant |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.2661 | INHERITED FROM: nicotine hypersensitive || drug hypersensitive || organism environmental stimulus response variant |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.2661 | INHERITED FROM: fat content variant || lipid metabolism variant |
49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0.2938 | INHERITED FROM: protein aggregation variant || protein protein interaction variant || protein interaction variant |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.2963 | INHERITED FROM: cadmium response variant || RNAi response variant || metal response variant || organism environmental stimulus response variant || colchicine hypersensitive |
50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0.3246 | INHERITED FROM: aqueous positive chemotaxis defective || drug resistant || positive chemotaxis variant || positive chemotaxis defective || mechanosensation variant || negative chemotaxis variant || dauer defective || osmotic avoidance variant || ivermectin response variant || pesticide response variant || odorant chemosensory response variant || ivermectin resistant || chemotaxis variant || aqueous chemosensory response variant || aqueous positive chemotaxis variant |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.3246 | INHERITED FROM: protein aggregation variant || protein protein interaction variant || protein interaction variant || pattern of transgene expression variant |
47473,47473
47473 - EF-hand
47473 - EF-hand | 0.3588 | INHERITED FROM: acetylcholinesterase inhibitor hypersensitive || aldicarb response variant || acetylcholinesterase inhibitor response variant |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.3801 | INHERITED FROM: starvation induced apoptosis variant || gene expression variant || late larval arrest || organism starvation response variant |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.4079 | INHERITED FROM: chemical response variant || positive chemotaxis variant || slowing response on food variant || sodium chloride chemotaxis variant || nicotine resistant || mechanosensation variant || DMPP response variant || drug response variant || cholinergic agonist resistant || antihelmintic response variant || selenium response variant || aqueous chemosensory response variant || organism environmental stimulus response variant || hypoosmotic shock hypersensitive |
48403,48403
48403 - Ankyrin repeat
48403 - Ankyrin repeat | 0.4795 | INHERITED FROM: organism environmental stimulus response variant |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.4976 | INHERITED FROM: protein expression variant || organism metabolism processing variant || protein expression reduced |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.5208 | INHERITED FROM: cadmium hypersensitive || enzyme activity reduced || organism stress response variant || organism heat hypersensitive || metal response variant || enzyme activity variant || organism electrophilic stress hypersensitive || paraquat response variant || organism environmental stimulus response variant |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.5285 | INHERITED FROM: protein expression reduced || growth rate variant |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.5599 | INHERITED FROM: chemical hypersensitive || SDS sensitive dauer || dauer resistance to harsh conditions variant |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.5788 | INHERITED FROM: protein expression reduced |
63380,52343
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.6361 | INHERITED FROM: transgene subcellular localization variant |
51045,51045
51045 - WW domain
51045 - WW domain | 0.6361 | INHERITED FROM: transgene expression variant |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0.6753 | INHERITED FROM: shortened life span || life span variant |
57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.6753 | INHERITED FROM: protein expression reduced |
50249,55681
50249 - Nucleic acid-binding proteins
55681 - Class II aaRS and biotin synthetases | 0.6994 | INHERITED FROM: transgene expression increased |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0.6994 | INHERITED FROM: organism UV response variant || organism UV hypersensitive || organism environmental stimulus response variant |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0.7682 | INHERITED FROM: level of protein expression variant || protein expression variant || protein expression reduced |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.8519 | INHERITED FROM: chemical response variant || aldicarb resistant || protein degradation variant || growth rate variant |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.8992 | INHERITED FROM: protein degradation variant || growth rate variant |
54211,55666
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like | 0.9508 | INHERITED FROM: early larval arrest |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.959 | INHERITED FROM: drug resistant |
53300,56436
53300 - vWA-like
56436 - C-type lectin-like | 1 | INHERITED FROM: pathogen susceptibility increased || pathogen induced death increased |
57850,57845
57850 - RING/U-box
57845 - B-box zinc-binding domain | 1 | INHERITED FROM: protein aggregation variant || transgene subcellular localization variant || transgene expression variant || protein protein interaction variant || protein interaction variant |
57850,57850
57850 - RING/U-box
57850 - RING/U-box | 1 | INHERITED FROM: protein aggregation variant || transgene subcellular localization variant || protein protein interaction variant || protein interaction variant |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 1 | INHERITED FROM: fat content variant || lipid metabolism variant |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0 | Direct |
141673,50800
141673 - MOSC N-terminal domain-like
50800 - PK beta-barrel domain-like | 0 | Direct |
50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | Direct |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | Direct |
57889,48350
57889 - Cysteine-rich domain
48350 - GTPase activation domain, GAP | 0 | Direct |
54897,53187
54897 - Protease propeptides/inhibitors
53187 - Zn-dependent exopeptidases | 0 | Direct |
141739,141739
141739 - MFPT repeat-like
141739 - MFPT repeat-like | 0 | Direct |
53187,55031
53187 - Zn-dependent exopeptidases
55031 - Bacterial exopeptidase dimerisation domain | 0 | Direct |
57414,57414
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like | 0 | Direct |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | Direct |
81383,52047
81383 - F-box domain
52047 - RNI-like | 0 | Direct |
57889,50729
57889 - Cysteine-rich domain
50729 - PH domain-like | 0 | Direct |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | Direct |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | Direct |
47741,56176
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like | 0 | Direct |
81631,55003
81631 - PAP/OAS1 substrate-binding domain
55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | Direct |
53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | Direct |
57756,50630
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases | 0 | Direct |
53474,53474
53474 - alpha/beta-Hydrolases
53474 - alpha/beta-Hydrolases | 0 | Direct |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | Direct |
48403,52151
48403 - Ankyrin repeat
52151 - FabD/lysophospholipase-like | 0 | Direct |
101690,53098
101690 - PAZ domain
53098 - Ribonuclease H-like | 0 | Direct |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
53901,53901
53901 - Thiolase-like
53901 - Thiolase-like | 0 | Direct |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | Direct |
51971,54373
51971 - Nucleotide-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0 | Direct |
161111,160240
161111 - Cation efflux protein transmembrane domain-like
160240 - Cation efflux protein cytoplasmic domain-like | 0 | Direct |
51735,56327
51735 - NAD(P)-binding Rossmann-fold domains
56327 - LDH C-terminal domain-like | 0 | Direct |
51735,55347
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | Direct |
56601,48403
56601 - beta-lactamase/transpeptidase-like
48403 - Ankyrin repeat | 0 | Direct |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0 | Direct |
56059,52210
56059 - Glutathione synthetase ATP-binding domain-like
52210 - Succinyl-CoA synthetase domains | 0 | Direct |
54495,46934
54495 - UBC-like
46934 - UBA-like | 0 | Direct |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | Direct |
48431,56968
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0 | Direct |
47576,47576
47576 - Calponin-homology domain, CH-domain
47576 - Calponin-homology domain, CH-domain | 0 | Direct |
57756,57756
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains | 0 | Direct |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
82615,82615
82615 - Polo-box domain
82615 - Polo-box domain | 0 | Direct |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0 | Direct |
81301,81631
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain | 0 | Direct |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
57863,48403
57863 - ArfGap/RecO-like zinc finger
48403 - Ankyrin repeat | 0 | Direct |
52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0 | Direct |
57196,63825
57196 - EGF/Laminin
63825 - YWTD domain | 0 | Direct |
57903,82199
57903 - FYVE/PHD zinc finger
82199 - SET domain | 0 | Direct |
55326,56042
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like | 0 | Direct |
51735,50129
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | Direct |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0 | Direct |
54695,81382
54695 - POZ domain
81382 - Skp1 dimerisation domain-like | 0 | Direct |
64356,49447
64356 - SNARE-like
49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
81324,53850
81324 - Voltage-gated potassium channels
53850 - Periplasmic binding protein-like II | 0 | Direct |
54665,56003
54665 - CO dehydrogenase molybdoprotein N-domain-like
56003 - Molybdenum cofactor-binding domain | 0 | Direct |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | Direct |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0 | Direct |
56112,48371
56112 - Protein kinase-like (PK-like)
48371 - ARM repeat | 0 | Direct |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | Direct |
53187,49464
53187 - Zn-dependent exopeptidases
49464 - Carboxypeptidase regulatory domain-like | 0 | Direct |
81698,81698
81698 - FF domain
81698 - FF domain | 0 | Direct |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | Direct |
57362,57362
57362 - BPTI-like
57362 - BPTI-like | 0 | Direct |
57938,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
52540,90123
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0 | Direct |
161093,161093
161093 - MgtE membrane domain-like
161093 - MgtE membrane domain-like | 0 | Direct |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0 | Direct |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
81333,81333
81333 - F1F0 ATP synthase subunit C
81333 - F1F0 ATP synthase subunit C | 0 | Direct |
54292,47741
54292 - 2Fe-2S ferredoxin-like
47741 - CO dehydrogenase ISP C-domain like | 0 | Direct |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | Direct |
52283,51735
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
88713,88688
88713 - Glycoside hydrolase/deacetylase
88688 - Families 57/38 glycoside transferase middle domain | 0 | Direct |
55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | Direct |
81383,50978
81383 - F-box domain
50978 - WD40 repeat-like | 0 | Direct |
51905,56425
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
56672,100879
56672 - DNA/RNA polymerases
100879 - Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
68923,53795
68923 - PEP carboxykinase N-terminal domain
53795 - PEP carboxykinase-like | 0 | Direct |
57850,117839
57850 - RING/U-box
117839 - WWE domain | 0 | Direct |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0 | Direct |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0 | Direct |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0 | Direct |
54236,54236
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0 | Direct |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | Direct |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0 | Direct |
144232,82199
144232 - HIT/MYND zinc finger-like
82199 - SET domain | 0 | Direct |
50044,52540
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
49742,49742
49742 - PHM/PNGase F
49742 - PHM/PNGase F | 0 | Direct |
52540,81271
52540 - P-loop containing nucleoside triphosphate hydrolases
81271 - TGS-like | 0 | Direct |
50156,50044
50156 - PDZ domain-like
50044 - SH3-domain | 0 | Direct |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | Direct |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
46938,52087
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain | 0 | Direct |
56968,48431
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
55394,55394
55394 - Bactericidal permeability-increasing protein, BPI
55394 - Bactericidal permeability-increasing protein, BPI | 0 | Direct |
54211,55060
54211 - Ribosomal protein S5 domain 2-like
55060 - GHMP Kinase, C-terminal domain | 0 | Direct |
52113,52113
52113 - BRCT domain
52113 - BRCT domain | 0 | Direct |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0 | Direct |
51445,51445
51445 - (Trans)glycosidases
51445 - (Trans)glycosidases | 0 | Direct |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | Direct |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | Direct |
81324,81327
81324 - Voltage-gated potassium channels
81327 - Small-conductance potassium channel | 0 | Direct |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | Direct |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | Direct |
52047,48371
52047 - RNI-like
48371 - ARM repeat | 0 | Direct |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | Direct |
46785,46785
46785 - "Winged helix" DNA-binding domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0 | Direct |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0 | Direct |
47473,103506
47473 - EF-hand
103506 - Mitochondrial carrier | 0 | Direct |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | Direct |
52540,140990
52540 - P-loop containing nucleoside triphosphate hydrolases
140990 - FtsH protease domain-like | 0 | Direct |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | Direct |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
55920,46785
55920 - Creatinase/aminopeptidase
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
49493,49493
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
53738,55957
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | Direct |
50044,50044
50044 - SH3-domain
50044 - SH3-domain | 0 | Direct |
74650,51445
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases | 0 | Direct |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
51556,51338
51556 - Metallo-dependent hydrolases
51338 - Composite domain of metallo-dependent hydrolases | 0 | Direct |
47587,56399
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | Direct |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0 | Direct |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0 | Direct |
48464,89009
48464 - ENTH/VHS domain
89009 - GAT-like domain | 0 | Direct |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0 | Direct |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0 | Direct |
81324,81296
81324 - Voltage-gated potassium channels
81296 - E set domains | 0 | Direct |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
51445,54556
51445 - (Trans)glycosidases
54556 - Chitinase insertion domain | 0 | Direct |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
50978,50998
50978 - WD40 repeat-like
50998 - Quinoprotein alcohol dehydrogenase-like | 0 | Direct |
51338,51556
51338 - Composite domain of metallo-dependent hydrolases
51556 - Metallo-dependent hydrolases | 0 | Direct |
48425,50729
48425 - Sec7 domain
50729 - PH domain-like | 0 | Direct |
56112,82615
56112 - Protein kinase-like (PK-like)
82615 - Polo-box domain | 0 | Direct |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | Direct |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | Direct |
52047,52047
52047 - RNI-like
52047 - RNI-like | 0 | Direct |
57625,57625
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins | 0 | Direct |
51445,51011
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0 | Direct |
52440,56059
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 0 | Direct |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | Direct |
55729,55729
55729 - Acyl-CoA N-acyltransferases (Nat)
55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | Direct |
103473,103473
103473 - MFS general substrate transporter
103473 - MFS general substrate transporter | 0 | Direct |
54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | Direct |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
47203,47203
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | Direct |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | Direct |
82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | Direct |
48179,48179
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.00252 | Inherited |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.01561 | Inherited |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.1172 | Inherited |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0.144 | Inherited |
56112,55073
56112 - Protein kinase-like (PK-like)
55073 - Nucleotide cyclase | 0.144 | Inherited |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0.1748 | Inherited |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0.2174 | Inherited |
56436,49854
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain | 0.2625 | Inherited |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.2661 | Inherited |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.2661 | Inherited |
49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0.2938 | Inherited |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.2963 | Inherited |
50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0.3246 | Inherited |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.3246 | Inherited |
47473,47473
47473 - EF-hand
47473 - EF-hand | 0.3588 | Inherited |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.3801 | Inherited |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.4079 | Inherited |
48403,48403
48403 - Ankyrin repeat
48403 - Ankyrin repeat | 0.4795 | Inherited |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.4976 | Inherited |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.5208 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.5285 | Inherited |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.5599 | Inherited |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.5788 | Inherited |
63380,52343
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.6361 | Inherited |
51045,51045
51045 - WW domain
51045 - WW domain | 0.6361 | Inherited |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0.6753 | Inherited |
57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.6753 | Inherited |
50249,55681
50249 - Nucleic acid-binding proteins
55681 - Class II aaRS and biotin synthetases | 0.6994 | Inherited |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0.6994 | Inherited |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0.7682 | Inherited |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.8519 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.8992 | Inherited |
54211,55666
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like | 0.9508 | Inherited |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.959 | Inherited |
53300,56436
53300 - vWA-like
56436 - C-type lectin-like | 1 | Inherited |
57850,57845
57850 - RING/U-box
57845 - B-box zinc-binding domain | 1 | Inherited |
57850,57850
57850 - RING/U-box
57850 - RING/U-box | 1 | Inherited |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 1 | Inherited |
(show details)
Supra-domains annotated to this WP term (Not in SPWP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57362,57362,57362
57362 - BPTI-like
57362 - BPTI-like
57362 - BPTI-like | 0 | DIRECT |
52540,90123,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
48726,49265,48726
48726 - Immunoglobulin
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | DIRECT |
50156,50044,52540
50156 - PDZ domain-like
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
81301,81631,55003
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain
55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | DIRECT |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
51735,48179,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
56968,48431,56968
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
63411,63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0 | DIRECT |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | DIRECT |
56112,82615,82615
56112 - Protein kinase-like (PK-like)
82615 - Polo-box domain
82615 - Polo-box domain | 0 | DIRECT |
82895,82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
74650,51445,51011
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0 | DIRECT |
53738,53738,55957
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0 | DIRECT |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | DIRECT |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
48452,48452,48452
48452 - TPR-like
48452 - TPR-like
48452 - TPR-like | 0 | DIRECT |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
50249,50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
50129,51735,50129
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | DIRECT |
53738,53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | DIRECT |
49785,49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
48371,48371,48371
48371 - ARM repeat
48371 - ARM repeat
48371 - ARM repeat | 0 | DIRECT |
57414,57414,57414
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like | 0 | DIRECT |
90123,52540,90123
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0 | DIRECT |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0 | DIRECT |
57625,57625,57625
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins | 0 | DIRECT |
54928,54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0 | DIRECT |
55973,55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | DIRECT |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | DIRECT |
46938,52087,101576
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain
101576 - Supernatant protein factor (SPF), C-terminal domain | 0 | DIRECT |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57567,57567,57567
57567 - Serine protease inhibitors
57567 - Serine protease inhibitors
57567 - Serine protease inhibitors | 0 | DIRECT |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
56436,49854,49854
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
57938,49493,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
54292,47741,56176
54292 - 2Fe-2S ferredoxin-like
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like | 0 | DIRECT |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | DIRECT |
50044,50044,50044
50044 - SH3-domain
50044 - SH3-domain
50044 - SH3-domain | 0 | DIRECT |
56645,47203,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0 | DIRECT |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.16 | INHERITED FROM: nicotine hypersensitive || drug hypersensitive || organism environmental stimulus response variant || lipid composition variant |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.3951 | INHERITED FROM: level of protein expression variant || protein expression reduced |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.3951 | INHERITED FROM: protein aggregation variant || protein protein interaction variant || protein interaction variant || pattern of transgene expression variant |
56436,56436,49854
56436 - C-type lectin-like
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain | 0.4066 | INHERITED FROM: cadmium hypersensitive || cadmium response variant |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.4795 | INHERITED FROM: level of protein expression variant || protein expression variant || protein degradation variant || organism metabolism processing variant || protein expression reduced |
57850,57850,57850
57850 - RING/U-box
57850 - RING/U-box
57850 - RING/U-box | 0.8763 | INHERITED FROM: protein aggregation variant || transgene subcellular localization variant || protein protein interaction variant || protein interaction variant || pattern of transgene expression variant |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.9852 | INHERITED FROM: protein degradation variant || growth rate variant |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 1 | INHERITED FROM: protein degradation variant || growth rate variant |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57362,57362,57362
57362 - BPTI-like
57362 - BPTI-like
57362 - BPTI-like | 0 | Direct |
52540,90123,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
48726,49265,48726
48726 - Immunoglobulin
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | Direct |
50156,50044,52540
50156 - PDZ domain-like
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
81301,81631,55003
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain
55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | Direct |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
51735,48179,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
56968,48431,56968
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
63411,63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0 | Direct |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | Direct |
56112,82615,82615
56112 - Protein kinase-like (PK-like)
82615 - Polo-box domain
82615 - Polo-box domain | 0 | Direct |
82895,82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | Direct |
74650,51445,51011
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0 | Direct |
53738,53738,55957
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | Direct |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0 | Direct |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | Direct |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
48452,48452,48452
48452 - TPR-like
48452 - TPR-like
48452 - TPR-like | 0 | Direct |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
50249,50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | Direct |
50129,51735,50129
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | Direct |
53738,53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | Direct |
49785,49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0 | Direct |
48371,48371,48371
48371 - ARM repeat
48371 - ARM repeat
48371 - ARM repeat | 0 | Direct |
57414,57414,57414
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like | 0 | Direct |
90123,52540,90123
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0 | Direct |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0 | Direct |
57625,57625,57625
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins | 0 | Direct |
54928,54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0 | Direct |
55973,55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | Direct |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | Direct |
46938,52087,101576
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain
101576 - Supernatant protein factor (SPF), C-terminal domain | 0 | Direct |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57567,57567,57567
57567 - Serine protease inhibitors
57567 - Serine protease inhibitors
57567 - Serine protease inhibitors | 0 | Direct |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
56436,49854,49854
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | Direct |
57938,49493,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | Direct |
54292,47741,56176
54292 - 2Fe-2S ferredoxin-like
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like | 0 | Direct |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | Direct |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | Direct |
50044,50044,50044
50044 - SH3-domain
50044 - SH3-domain
50044 - SH3-domain | 0 | Direct |
56645,47203,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0 | Direct |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.16 | Inherited |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.3951 | Inherited |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.3951 | Inherited |
56436,56436,49854
56436 - C-type lectin-like
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain | 0.4066 | Inherited |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.4795 | Inherited |
57850,57850,57850
57850 - RING/U-box
57850 - RING/U-box
57850 - RING/U-box | 0.8763 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.9852 | Inherited |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 1 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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