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Worm Phenotype (WP): organism physiology variant
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Chaperone J-domain | 0 | DIRECT |
| GYF domain | 0 | DIRECT |
| Putative DNA-binding domain | 0 | DIRECT |
| PUA domain-like | 0 | DIRECT |
| Troponin coil-coiled subunits | 0 | DIRECT |
| YbiA-like | 0 | DIRECT |
| Actin-like ATPase domain | 0 | DIRECT |
| PLC-like phosphodiesterases | 0 | DIRECT |
| Complement control module/SCR domain | 0 | DIRECT |
| Polo-box domain | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| Ran binding protein zinc finger-like | 0 | DIRECT |
| Glycolipid transfer protein, GLTP | 0 | DIRECT |
| Ribokinase-like | 0 | DIRECT |
| Profilin (actin-binding protein) | 0 | DIRECT |
| Phoshotransferase/anion transport protein | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| Integrin alpha N-terminal domain | 0 | DIRECT |
| Tricorn protease domain 2 | 0 | DIRECT |
| Aldolase | 0 | DIRECT |
| Sec63 N-terminal domain-like | 0 | DIRECT |
| cAMP-binding domain-like | 0 | DIRECT |
| Heme-dependent peroxidases | 0 | DIRECT |
| DNA repair protein MutS, domain III | 0 | DIRECT |
| Invertebrate chitin-binding proteins | 0 | DIRECT |
| Pentein | 0 | DIRECT |
| Rap/Ran-GAP | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
| GroEL apical domain-like | 0 | DIRECT |
| Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
| Chitinase insertion domain | 0 | DIRECT |
| Skp1 dimerisation domain-like | 0 | DIRECT |
| GINS helical bundle-like | 0 | DIRECT |
| CAD & PB1 domains | 0 | DIRECT |
| Subtilisin-like | 0 | DIRECT |
| Thyroglobulin type-1 domain | 0 | DIRECT |
| Class I glutamine amidotransferase-like | 0 | DIRECT |
| LEM domain | 0 | DIRECT |
| L30e-like | 0 | DIRECT |
| Ribosomal protein L10-like | 0 | DIRECT |
| Thiolase-like | 0 | DIRECT |
| TGS-like | 0 | DIRECT |
| Doublecortin (DC) | 0 | DIRECT |
| Spectrin repeat | 0 | DIRECT |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| WGR domain-like | 0 | DIRECT |
| GroEL equatorial domain-like | 0 | DIRECT |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0 | DIRECT |
| PurM N-terminal domain-like | 0 | DIRECT |
| Surp module (SWAP domain) | 0 | DIRECT |
| Heme-dependent catalase-like | 0 | DIRECT |
| PAP/OAS1 substrate-binding domain | 0 | DIRECT |
| PEP carboxykinase-like | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| PK beta-barrel domain-like | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| Insulin-like | 0 | DIRECT |
| Creatinase/prolidase N-terminal domain | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
| Ribosomal L27 protein-like | 0 | DIRECT |
| LDH C-terminal domain-like | 0 | DIRECT |
| BEACH domain | 0 | DIRECT |
| Small-conductance potassium channel | 0 | DIRECT |
| Carbon-nitrogen hydrolase | 0 | DIRECT |
| Tubulin C-terminal domain-like | 0 | DIRECT |
| ThrRS/AlaRS common domain | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| PurM C-terminal domain-like | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| Hedgehog/intein (Hint) domain | 0 | DIRECT |
| Galactose mutarotase-like | 0 | DIRECT |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
| LysM domain | 0 | DIRECT |
| ArfGap/RecO-like zinc finger | 0 | DIRECT |
| Tubby C-terminal domain-like | 0 | DIRECT |
| Translational machinery components | 0 | DIRECT |
| R3H domain | 0 | DIRECT |
| Nucleotidyltransferase | 0 | DIRECT |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| Ferritin-like | 0 | DIRECT |
| MgtE membrane domain-like | 0 | DIRECT |
| Band 7/SPFH domain | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Hypothetical protein c14orf129, hspc210 | 0 | DIRECT |
| Intermediate filament protein, coiled coil region | 0 | DIRECT |
| 2Fe-2S ferredoxin-like | 0 | DIRECT |
| Galactose oxidase, central domain | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| HSP20-like chaperones | 0 | DIRECT |
| Families 57/38 glycoside transferase middle domain | 0 | DIRECT |
| Tim10-like | 0 | DIRECT |
| CBD9-like | 0 | DIRECT |
| Cullin repeat-like | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| PYP-like sensor domain (PAS domain) | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| t-snare proteins | 0 | DIRECT |
| PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | DIRECT |
| GAS2 domain-like | 0 | DIRECT |
| Diaminopimelate epimerase-like | 0 | DIRECT |
| CO dehydrogenase ISP C-domain like | 0 | DIRECT |
| beta-lactamase/transpeptidase-like | 0 | DIRECT |
| Periplasmic binding protein-like II | 0 | DIRECT |
| PABC (PABP) domain | 0 | DIRECT |
| Rudiment single hybrid motif | 0 | DIRECT |
| RBP11-like subunits of RNA polymerase | 0 | DIRECT |
| TK C-terminal domain-like | 0 | DIRECT |
| Outer arm dynein light chain 1 | 0 | DIRECT |
| SMAD/FHA domain | 0 | DIRECT |
| Carbohydrate phosphatase | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| JAB1/MPN domain | 0 | DIRECT |
| Restriction endonuclease-like | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| Kringle-like | 0 | DIRECT |
| Arginase/deacetylase | 0 | DIRECT |
| HMG-box | 0 | DIRECT |
| Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
| S-adenosylmethionine synthetase | 0 | DIRECT |
| GAT-like domain | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| Molybdenum cofactor-binding domain | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| SAND domain-like | 0 | DIRECT |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| GroES-like | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | DIRECT |
| VPS9 domain | 0 | DIRECT |
| ClpP/crotonase | 0 | DIRECT |
| FtsH protease domain-like | 0 | DIRECT |
| Citrate synthase | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Purine and uridine phosphorylases | 0 | DIRECT |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| Nucleoside diphosphate kinase, NDK | 0 | DIRECT |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | DIRECT |
| Ribosomal protein L1 | 0 | DIRECT |
| Second domain of FERM | 0 | DIRECT |
| ADP-ribosylation | 0 | DIRECT |
| Annexin | 0 | DIRECT |
| Calcium-dependent phosphotriesterase | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| ARID-like | 0 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
| Ribosomal protein S10 | 0 | DIRECT |
| YWTD domain | 0 | DIRECT |
| alpha-catenin/vinculin-like | 0 | DIRECT |
| Carboxypeptidase regulatory domain-like | 0 | DIRECT |
| Oxysterol-binding protein-like | 0 | DIRECT |
| Radical SAM enzymes | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| HCP-like | 0 | DIRECT |
| HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| MOSC N-terminal domain-like | 0 | DIRECT |
| Acyl-CoA dehydrogenase NM domain-like | 0 | DIRECT |
| lambda repressor-like DNA-binding domains | 0 | DIRECT |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | DIRECT |
| AN1-like Zinc finger | 0 | DIRECT |
| Terpenoid synthases | 0 | DIRECT |
| L-aspartase-like | 0 | DIRECT |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
| Fibrinogen C-terminal domain-like | 0 | DIRECT |
| Tubulin nucleotide-binding domain-like | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
| PIN domain-like | 0 | DIRECT |
| DEATH domain | 0 | DIRECT |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | DIRECT |
| Zn-binding ribosomal proteins | 0 | DIRECT |
| dsRNA-binding domain-like | 0 | DIRECT |
| GroEL-intermediate domain like | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| ISP domain | 0 | DIRECT |
| PHM/PNGase F | 0 | DIRECT |
| PreATP-grasp domain | 0 | DIRECT |
| WWE domain | 0 | DIRECT |
| Class II aaRS ABD-related | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| CRAL/TRIO N-terminal domain | 0 | DIRECT |
| GHMP Kinase, C-terminal domain | 0 | DIRECT |
| Type II DNA topoisomerase | 0 | DIRECT |
| SAICAR synthase-like | 0 | DIRECT |
| alpha/beta knot | 0 | DIRECT |
| Elafin-like | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | DIRECT |
| Hect, E3 ligase catalytic domain | 0 | DIRECT |
| Aquaporin-like | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| Single hybrid motif | 0 | DIRECT |
| Cytochrome c | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| Alpha-L RNA-binding motif | 0 | DIRECT |
| Pepsin inhibitor-3 | 0 | DIRECT |
| Chromo domain-like | 0 | DIRECT |
| ENTH/VHS domain | 0 | DIRECT |
| Activating enzymes of the ubiquitin-like proteins | 0 | DIRECT |
| Protease propeptides/inhibitors | 0 | DIRECT |
| Cystatin/monellin | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| eIF4e-like | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| PGBD-like | 0 | DIRECT |
| MFPT repeat-like | 0 | DIRECT |
| Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
| Cdc48 domain 2-like | 0 | DIRECT |
| Cadherin-like | 0 | DIRECT |
| SCP-like | 0 | DIRECT |
| Hormone receptor domain | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| PEBP-like | 0 | DIRECT |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0 | DIRECT |
| Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| Ribosomal proteins S24e, L23 and L15e | 0 | DIRECT |
| Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
| Clc chloride channel | 0 | DIRECT |
| Mitochondrial carrier | 0 | DIRECT |
| Nucleoporin domain | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| Carbonic anhydrase | 0 | DIRECT |
| SIS domain | 0 | DIRECT |
| Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| Sec7 domain | 0 | DIRECT |
| P-loop containing nucleoside triphosphate hydrolases | 0.0000002643 | DIRECT |
| PH domain-like | 0.0000866 | DIRECT |
| Histone-fold | 0.000196 | DIRECT |
| Protein kinase-like (PK-like) | 0.00946 | INHERITED FROM: chemical response variant || organism osmostic stress hypersensitive || positive chemotaxis variant || protein phosphorylation variant || metal response variant || aldicarb response variant || octanol chemotaxis defective || colchicine resistant || drug induced gene expression variant || protein expression variant || conflicting sensory integration variant || protein phosphorylation reduced || anoxia resistant || second messenger mediated signaling variant || organism environmental stimulus response variant || egg laying response to food variant || kinase activity reduced || transgene expression reduced || pathogen induced gene expression variant || alkaline pH chemotaxis variant || protein subcellular localization variant || lipid synthesis increased || life span variant |
| PDZ domain-like | 0.01494 | INHERITED FROM: drug resistant || aldicarb response variant || acetylcholinesterase inhibitor response variant |
| Nucleic acid-binding proteins | 0.02328 | INHERITED FROM: hypoxia resistant || hydroxyurea hypersensitive || hydroxyurea response variant || mRNA surveillance defective || nonsense mRNA accumulation || sick |
| Periplasmic binding protein-like I | 0.02382 | INHERITED FROM: chemical response variant || positive chemotaxis variant || AWC odorant chemotaxis variant || magnesium chemotaxis defective || bromide chemotaxis variant || benzaldehyde chemotaxis variant || chemosensory response variant || AWC odorant chemotaxis defective || response to food variant || iodide chemotaxis defective || aqueous positive chemotaxis variant || diacetyl chemotaxis variant || second messenger mediated signaling variant || lithium chemotaxis defective || memory retention defective || organism environmental stimulus response variant || chemotaxis variant || alkaline pH chemotaxis variant || carbon dioxide avoidance variant || aqueous chemosensory response variant || bromide chemotaxis defective || iodide chemotaxis variant |
| TPR-like | 0.0244 | INHERITED FROM: light body touch resistant || dauer defective || positive chemotaxis defective || chemotaxis variant || associative learning variant |
| "Winged helix" DNA-binding domain | 0.0259 | INHERITED FROM: protein expression increased || protein protein interaction variant || organism metabolism processing variant || anesthetic response variant || germline transgene silencing variant || spontaneous mutation rate increased || protein aggregation induced behavior variant || protein aggregation variant || paraquat hypersensitive || shortened life span || chemical hypersensitive || life span variant |
| PapD-like | 0.03966 | INHERITED FROM: larval growth variant || slow growth || dauer lifespan variant || dauer lifespan extended || dauer metabolism variant || fat content variant || lipid metabolism variant || larval arrest || developmental growth variant |
| WD40 repeat-like | 0.05061 | INHERITED FROM: protein protein interaction variant || organism metabolism processing variant || osmotic avoidance variant || antimicrobial gene expression variant || early larval arrest || late larval arrest || protein aggregation induced behavior variant || protein aggregation variant |
| ARM repeat | 0.05166 | INHERITED FROM: organism hypersensitive ionizing radiation || protein expression variant || organism metabolism processing variant || gene expression variant || sick || RNAi response variant |
| SH2 domain | 0.05667 | INHERITED FROM: protein expression reduced || protein expression variant || level of protein expression variant || aldicarb resistant || acetylcholinesterase inhibitor resistant |
| Homeodomain-like | 0.07674 | INHERITED FROM: adrenergic receptor antagonist response variant || level of transgene expression variant || egg laying imipramine resistant || sexually dimorphic physiology variant || protein degradation variant || ectopic expression transgene || organism metabolism processing variant || inhibitor of serotonin uptake variant || imipramine resistant || growth rate variant || carbon dioxide response variant || carbon dioxide avoidance variant |
| Calponin-homology domain, CH-domain | 0.07955 | INHERITED FROM: protein degradation variant |
| Acetyl-CoA synthetase-like | 0.07955 | INHERITED FROM: lipid metabolism variant |
| Cyclin-like | 0.08784 | INHERITED FROM: protein phosphorylation variant || protein phosphorylation reduced |
| CCCH zinc finger | 0.09686 | INHERITED FROM: ectopic expression transgene || transgene expression variant || mRNA expression ectopic || gene expression variant |
| EGF/Laminin | 0.09932 | INHERITED FROM: octanol chemotaxis defective || odorant negative chemotaxis defective || negative chemotaxis variant || octanol chemotaxis variant |
| Translation proteins | 0.118 | INHERITED FROM: protein phosphorylation variant || protein protein interaction variant || proteasome core activity variant || organism metabolism processing variant || transgene expression variant || gene expression variant || protein phosphorylation increased || protein aggregation variant || sick || mRNA levels increased |
| Galactose-binding domain-like | 0.1258 | INHERITED FROM: protein interaction variant || protein protein interaction variant || protein aggregation variant |
| Ankyrin repeat | 0.13 | INHERITED FROM: octanol chemotaxis defective || chemosensory response variant || organism heat response variant || odorant negative chemotaxis defective || chemotaxis variant || octanol chemotaxis variant |
| HLH, helix-loop-helix DNA-binding domain | 0.1471 | INHERITED FROM: gene expression level reduced || RNA expression variant || ectopic expression transgene || hypoxia response variant || organism metabolism processing variant || aqueous positive chemotaxis defective || lysine chemotaxis defective |
| Nucleotide cyclase | 0.1471 | INHERITED FROM: positive chemotaxis variant || AWC odorant chemotaxis variant || magnesium chemotaxis defective || cation positive chemotaxis variant || bromide chemotaxis variant || chemosensory response variant || AWC odorant chemotaxis defective || anion positive chemotaxis defective || iodide chemotaxis defective || osmotic avoidance variant || diacetyl chemotaxis variant || second messenger mediated signaling variant || cation positive chemotaxis defective || lithium chemotaxis defective || organism environmental stimulus response variant || chemotaxis variant || carbon dioxide response variant || alkaline pH chemotaxis variant || bromide chemotaxis defective || iodide chemotaxis variant |
| ABC transporter transmembrane region | 0.1471 | INHERITED FROM: colchicine hypersensitive || metal response variant || organism environmental stimulus response variant || cadmium response variant || RNAi response variant |
| RNI-like | 0.1551 | INHERITED FROM: resistant to protein aggregation induced paralysis |
| Calcium ATPase, transmembrane domain M | 0.1575 | INHERITED FROM: lipid composition variant || organism environmental stimulus response variant || nicotine hypersensitive |
| Regulator of G-protein signaling, RGS | 0.1737 | INHERITED FROM: mechanosensation variant || chemotaxis variant || negative chemotaxis variant |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1737 | INHERITED FROM: lipid composition variant || organism environmental stimulus response variant || nicotine hypersensitive |
| Class II aaRS and biotin synthetases | 0.1912 | INHERITED FROM: hypoxia resistant || hypoxia response variant || organism metabolism processing variant || transgene expression variant || oxygen response variant || gene expression variant || organism environmental stimulus response variant |
| Calcium ATPase, transduction domain A | 0.1912 | INHERITED FROM: organism environmental stimulus response variant || nicotine hypersensitive |
| SH3-domain | 0.1968 | INHERITED FROM: protein phosphorylation variant || protein expression reduced || aldicarb response variant || protein expression variant |
| E set domains | 0.1994 | INHERITED FROM: paraquat hypersensitive |
| Quinoprotein alcohol dehydrogenase-like | 0.21 | INHERITED FROM: protein degradation variant || L2 arrest || hypoxia response variant || mid larval arrest || fat content increased || mRNA levels increased |
| WW domain | 0.2311 | INHERITED FROM: maintenance of gene silencing variant |
| DBL homology domain (DH-domain) | 0.2311 | INHERITED FROM: aldicarb response variant || pathogen resistance increased || organism pathogen response variant || organism environmental stimulus response variant || bacterially unswollen |
| Multidrug efflux transporter AcrB transmembrane domain | 0.232 | INHERITED FROM: embryo osmotic integrity defective early emb || egg integrity defective early emb || positive chemotaxis defective || chemotaxis variant || odorant positive chemotaxis defective || odorant chemosensory response variant |
| (Trans)glycosidases | 0.2768 | INHERITED FROM: pathogen load variant || pathogen susceptibility increased |
| Cytochrome P450 | 0.2768 | INHERITED FROM: metal response variant || cadmium response variant |
| Multidrug resistance efflux transporter EmrE | 0.2788 | INHERITED FROM: pathogen resistance increased || bacterially unswollen |
| BRCT domain | 0.2877 | INHERITED FROM: organism ionizing radiation response variant |
| Bromodomain | 0.3057 | INHERITED FROM: drug adaptation variant || organism UV hypersensitive || anesthetic response variant || ethanol resistant || acute functional tolerance to alcohol defective || organism UV response variant || sick || anesthetic resistant |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.3057 | INHERITED FROM: fat content variant || lipid metabolism variant |
| Nucleotidylyl transferase | 0.3302 | INHERITED FROM: hypoxia resistant || transgene expression increased || hypoxia response variant || organism metabolism processing variant || paraquat resistant || oxygen response variant || organism environmental stimulus response variant |
| POZ domain | 0.3322 | INHERITED FROM: resistant to protein aggregation induced paralysis || L1 arrest || early larval arrest || protein aggregation induced behavior variant || chemical hypersensitive |
| SNARE-like | 0.3344 | INHERITED FROM: organism metabolism processing variant || transgene expression variant || aldicarb resistant || protein metabolism variant || acetylcholinesterase inhibitor resistant || pattern of transgene expression variant || gene expression variant || transgene subcellular localization variant || sick |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.3398 | INHERITED FROM: chemical response variant || drug resistant || drug induced gene expression variant || protein expression variant || nose touch variant || aging variant || metabolic pathway variant || antimicrobial gene expression variant || growth rate variant || organism environmental stimulus response variant || RNAi response variant || protein subcellular localization variant |
| Cysteine proteinases | 0.3412 | INHERITED FROM: protein interaction variant || protein protein interaction variant || organism metabolism processing variant || hypoosmotic shock hypersensitive || pattern of transgene expression variant || osmotic integrity variant || paraquat hypersensitive |
| RNA-binding domain, RBD | 0.3439 | INHERITED FROM: RNA expression variant || organism metabolism processing variant || mRNA export variant || RNA processing variant || no induction of antimicrobial peptide expression after infection || starvation induced apoptosis variant || alternative splicing variant || antimicrobial gene expression variant || maintenance of gene silencing variant || innate immune response variant || sick |
| Ribosomal protein S5 domain 2-like | 0.3501 | INHERITED FROM: transgene expression variant || early larval arrest |
| Lipocalins | 0.3538 | INHERITED FROM: fat content increased || fat content variant || lipid metabolism variant || paraquat hypersensitive |
| SAM/Pointed domain | 0.3538 | INHERITED FROM: aldicarb response variant |
| Translation proteins SH3-like domain | 0.4022 | INHERITED FROM: organism metabolism processing variant || transgene expression variant || gene expression variant || early larval arrest |
| Cation efflux protein transmembrane domain-like | 0.4022 | INHERITED FROM: manganese toxicity resistant || manganese response variant || metal response variant || cadmium hypersensitive |
| Acid proteases | 0.4321 | INHERITED FROM: protein interaction variant || protein protein interaction variant || organism metabolism processing variant || hypoosmotic shock hypersensitive || transgene expression variant || pattern of transgene expression variant || gene expression variant || transgene subcellular localization variant || protein aggregation variant || osmotic integrity variant |
| FKBP-like | 0.452 | INHERITED FROM: protein interaction variant || protein protein interaction variant || pattern of transgene expression variant || transgene subcellular localization variant || protein aggregation variant |
| Nicotinic receptor ligand binding domain-like | 0.453 | INHERITED FROM: chemical response variant || drug response variant || hypoosmotic shock hypersensitive || DMPP response variant || mechanosensation variant || selenium response variant || organism environmental stimulus response variant || sodium chloride chemotaxis variant || nicotine resistant || aqueous chemosensory response variant || antihelmintic response variant || cholinergic agonist resistant |
| Cysteine-rich domain | 0.4595 | INHERITED FROM: positive chemotaxis variant || aldicarb response variant || drug induced gene expression variant || organism metabolism processing variant || organism pathogen response variant || antimicrobial gene expression variant || bacterially unswollen || odorant positive chemotaxis variant || odorant chemosensory response variant || protein subcellular localization variant |
| Ubiquitin-like | 0.4636 | INHERITED FROM: protein interaction variant || protein protein interaction variant || heteroplasmy || organism metabolism processing variant || protein aggregation variant |
| FYVE/PHD zinc finger | 0.4655 | INHERITED FROM: protein methylation variant || organism UV hypersensitive || protein modification variant || ectopic expression transgene || organism UV response variant |
| HAD-like | 0.4845 | INHERITED FROM: nicotine hypersensitive |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.4891 | INHERITED FROM: chemical response variant || positive chemotaxis variant || protein degradation variant || drug response variant || hypoosmotic shock hypersensitive || DMPP response variant || mechanosensation variant || selenium response variant || organism environmental stimulus response variant || sodium chloride chemotaxis variant || nicotine resistant || aqueous chemosensory response variant || antihelmintic response variant || cholinergic agonist resistant |
| DHS-like NAD/FAD-binding domain | 0.5241 | INHERITED FROM: protein modification variant || protein acetylation variant || life span variant |
| Myosin rod fragments | 0.5241 | INHERITED FROM: drug resistant |
| PRTase-like | 0.5241 | INHERITED FROM: drug resistant || Fluorouracil resistant |
| Riboflavin synthase domain-like | 0.5722 | INHERITED FROM: pattern protein expression variant |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.5722 | INHERITED FROM: pattern protein expression variant |
| Calpain large subunit, middle domain (domain III) | 0.5722 | INHERITED FROM: protein degradation variant || metabolic pathway variant || protein metabolism variant |
| Cystine-knot cytokines | 0.5843 | INHERITED FROM: levamisole response variant || nicotine response variant |
| Sm-like ribonucleoproteins | 0.5843 | INHERITED FROM: organism heat response variant || transgene expression variant || pattern of transgene expression variant || gene expression variant || sick || unfolded protein response variant || protein subcellular localization variant || life span variant |
| FAD-linked reductases, C-terminal domain | 0.5843 | INHERITED FROM: life span variant |
| Voltage-gated potassium channels | 0.6176 | INHERITED FROM: adrenergic receptor antagonist response variant || protein degradation variant || serotonin response variant || metabolic pathway variant || protein metabolism variant || mechanosensation variant || positive chemotaxis defective || growth rate variant |
| Seven-hairpin glycosidases | 0.6218 | INHERITED FROM: protein protein interaction variant || protein aggregation variant || extended life span |
| FAD/NAD(P)-binding domain | 0.6235 | INHERITED FROM: ATP levels reduced || pesticide response variant || ATP levels variant || life span variant |
| SET domain | 0.6299 | INHERITED FROM: histone methylation variant || protein methylation variant || somatic transgene silencing variant || protein modification variant || protein expression variant || dosage compensation variant || spontaneous mutation rate increased || maintenance of gene silencing variant || RNAi response variant || ectopic expression antibody || shortened life span || life span variant |
| Growth factor receptor domain | 0.6384 | INHERITED FROM: protein degradation variant |
| UBC-like | 0.6536 | INHERITED FROM: protein interaction variant || protein protein interaction variant || organism metabolism processing variant || pattern of transgene expression variant || gene expression variant || transgene subcellular localization variant || late larval arrest || protein aggregation variant || sick |
| Clavaminate synthase-like | 0.667 | INHERITED FROM: organism temperature response variant || life span variant |
| KA1-like | 0.6779 | INHERITED FROM: RNA expression variant |
| Lipovitellin-phosvitin complex, superhelical domain | 0.6779 | INHERITED FROM: organism pathogen response variant || pathogen susceptibility increased || organism environmental stimulus response variant || life span variant |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.6779 | INHERITED FROM: organism pathogen response variant || pathogen susceptibility increased || organism environmental stimulus response variant || life span variant |
| Nucleotide-binding domain | 0.6779 | INHERITED FROM: extended life span || life span variant |
| Osmotin, thaumatin-like protein | 0.6779 | INHERITED FROM: metal response variant || cadmium hypersensitive || cadmium response variant |
| MFS general substrate transporter | 0.686 | INHERITED FROM: organism high sodium chloride hypersensitive |
| GTPase activation domain, GAP | 0.7275 | INHERITED FROM: protein expression variant |
| 4Fe-4S ferredoxins | 0.7385 | INHERITED FROM: extended life span |
| S15/NS1 RNA-binding domain | 0.7385 | INHERITED FROM: transgene expression increased |
| Frizzled cysteine-rich domain | 0.7385 | INHERITED FROM: antibody staining variant || transgene expression reduced |
| GST C-terminal domain-like | 0.7642 | INHERITED FROM: enzyme activity variant || enzyme activity reduced || cadmium hypersensitive || organism electrophilic stress hypersensitive || organism environmental stimulus response variant || cadmium response variant || organism heat hypersensitive || organism stress response variant |
| PAZ domain | 0.7985 | INHERITED FROM: RNA expression variant || RNAi enhanced || somatic transgene silencing variant || siRNA expression variant || maintenance of gene silencing variant || 21U RNA expression variant || RNAi response variant || mRNA levels increased |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.8019 | INHERITED FROM: gene expression level reduced || dauer resistance to harsh conditions variant || level of transgene expression variant || SDS sensitive dauer || gene expression level high || fat content increased || transgene expression reduced |
| Ribonuclease H-like | 0.8027 | INHERITED FROM: RNA expression variant || RNAi enhanced || somatic transgene silencing variant || siRNA expression variant || maintenance of gene silencing variant || 21U RNA expression variant || RNAi response variant |
| MIT domain | 0.8035 | INHERITED FROM: protein interaction variant || protein protein interaction variant || protein aggregation variant |
| ADC-like | 0.8035 | INHERITED FROM: level of transgene expression variant || protein interaction variant || protein protein interaction variant || metabolic pathway variant || protein metabolism variant || protein aggregation variant |
| alpha/beta-Hydrolases | 0.8132 | INHERITED FROM: acetylcholinesterase reduced || acetylcholinesterase activity variant |
| Fibronectin type III | 0.8595 | INHERITED FROM: protein degradation variant || growth rate variant |
| Leucine zipper domain | 0.8992 | INHERITED FROM: level of transgene expression variant || mRNA expression variant || pathogen susceptibility increased || pore forming toxin response variant || transgene expression reduced || mRNA levels reduced |
| UBA-like | 0.9103 | INHERITED FROM: protein protein interaction variant || protein aggregation variant |
| EF-hand | 0.9132 | INHERITED FROM: protein interaction variant || protein aggregation variant |
| DNA/RNA polymerases | 0.9644 | INHERITED FROM: DNA metabolism variant || DNA repair variant |
| p53-like transcription factors | 0.973 | INHERITED FROM: gene expression level reduced || level of transgene expression variant || ectopic expression transgene |
| Ribonuclease PH domain 2-like | 0.9747 | INHERITED FROM: early larval arrest |
| beta-beta-alpha zinc fingers | 0.997 | INHERITED FROM: egg laying imipramine resistant || organism metabolism processing variant || inhibitor of serotonin uptake variant || imipramine resistant || egg laying serotonin resistant |
| Immunoglobulin | 0.9996 | INHERITED FROM: protein degradation variant || aldicarb response variant || growth rate variant |
| Thioredoxin-like | 1 | INHERITED FROM: enzyme activity variant || paraquat response variant || enzyme activity reduced || cadmium hypersensitive || organism electrophilic stress hypersensitive || organism environmental stimulus response variant || organism heat hypersensitive || organism stress response variant |
| Saposin | 1 | INHERITED FROM: level of transgene expression variant || increased pathogen survival || pathogen load variant || transgene expression variant || transgene expression reduced |
| Bet v1-like | 1 | INHERITED FROM: growth rate variant |
| Nuclear receptor ligand-binding domain | 1 | INHERITED FROM: gene expression level reduced || dauer resistance to harsh conditions variant || level of transgene expression variant || SDS sensitive dauer || gene expression level high || fat content increased || lipid metabolism variant || transgene expression reduced |
| CoA-dependent acyltransferases | 1 | INHERITED FROM: lipid metabolism variant |
| B-box zinc-binding domain | 1 | INHERITED FROM: protein interaction variant || protein protein interaction variant || organism metabolism processing variant || transgene expression variant || gene expression variant || transgene subcellular localization variant || protein aggregation variant |
| Eukaryotic type KH-domain (KH-domain type I) | 1 | INHERITED FROM: RNA expression variant |
| Cyclophilin-like | 1 | INHERITED FROM: protein interaction variant || protein protein interaction variant || transgene expression variant || pattern of transgene expression variant || gene expression variant || transgene subcellular localization variant || protein aggregation variant |
| F-box domain | 1 | INHERITED FROM: resistant to protein aggregation induced paralysis |
| Family A G protein-coupled receptor-like | 1 | INHERITED FROM: locomotion rate serotonin variant || male tail curling serotonin variant || serotonin induced fat reduction variant || serotonin induced pumping variant |
| Ligand-binding domain in the NO signalling and Golgi transport | 1 | INHERITED FROM: carbon dioxide response variant || carbon dioxide avoidance variant |
| RING/U-box | 1 | INHERITED FROM: protein interaction variant || protein protein interaction variant || organism metabolism processing variant || transgene expression variant || pattern of transgene expression variant || gene expression variant || transgene subcellular localization variant || protein aggregation variant |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Chaperone J-domain | 0 | Direct |
| GYF domain | 0 | Direct |
| Putative DNA-binding domain | 0 | Direct |
| PUA domain-like | 0 | Direct |
| Troponin coil-coiled subunits | 0 | Direct |
| YbiA-like | 0 | Direct |
| Actin-like ATPase domain | 0 | Direct |
| PLC-like phosphodiesterases | 0 | Direct |
| Complement control module/SCR domain | 0 | Direct |
| Polo-box domain | 0 | Direct |
| ALDH-like | 0 | Direct |
| Ran binding protein zinc finger-like | 0 | Direct |
| Glycolipid transfer protein, GLTP | 0 | Direct |
| Ribokinase-like | 0 | Direct |
| Profilin (actin-binding protein) | 0 | Direct |
| Phoshotransferase/anion transport protein | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| Integrin alpha N-terminal domain | 0 | Direct |
| Tricorn protease domain 2 | 0 | Direct |
| Aldolase | 0 | Direct |
| Sec63 N-terminal domain-like | 0 | Direct |
| cAMP-binding domain-like | 0 | Direct |
| Heme-dependent peroxidases | 0 | Direct |
| DNA repair protein MutS, domain III | 0 | Direct |
| Invertebrate chitin-binding proteins | 0 | Direct |
| Pentein | 0 | Direct |
| Rap/Ran-GAP | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| Bacterial exopeptidase dimerisation domain | 0 | Direct |
| GroEL apical domain-like | 0 | Direct |
| Cation efflux protein cytoplasmic domain-like | 0 | Direct |
| Chitinase insertion domain | 0 | Direct |
| Skp1 dimerisation domain-like | 0 | Direct |
| GINS helical bundle-like | 0 | Direct |
| CAD & PB1 domains | 0 | Direct |
| Subtilisin-like | 0 | Direct |
| Thyroglobulin type-1 domain | 0 | Direct |
| Class I glutamine amidotransferase-like | 0 | Direct |
| LEM domain | 0 | Direct |
| L30e-like | 0 | Direct |
| Ribosomal protein L10-like | 0 | Direct |
| Thiolase-like | 0 | Direct |
| TGS-like | 0 | Direct |
| Doublecortin (DC) | 0 | Direct |
| Spectrin repeat | 0 | Direct |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | Direct |
| WGR domain-like | 0 | Direct |
| GroEL equatorial domain-like | 0 | Direct |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| Transducin (alpha subunit), insertion domain | 0 | Direct |
| PurM N-terminal domain-like | 0 | Direct |
| Surp module (SWAP domain) | 0 | Direct |
| Heme-dependent catalase-like | 0 | Direct |
| PAP/OAS1 substrate-binding domain | 0 | Direct |
| PEP carboxykinase-like | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| PK beta-barrel domain-like | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| Insulin-like | 0 | Direct |
| Creatinase/prolidase N-terminal domain | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
| Ribosomal L27 protein-like | 0 | Direct |
| LDH C-terminal domain-like | 0 | Direct |
| BEACH domain | 0 | Direct |
| Small-conductance potassium channel | 0 | Direct |
| Carbon-nitrogen hydrolase | 0 | Direct |
| Tubulin C-terminal domain-like | 0 | Direct |
| ThrRS/AlaRS common domain | 0 | Direct |
| Nop domain | 0 | Direct |
| PurM C-terminal domain-like | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| Hedgehog/intein (Hint) domain | 0 | Direct |
| Galactose mutarotase-like | 0 | Direct |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
| LysM domain | 0 | Direct |
| ArfGap/RecO-like zinc finger | 0 | Direct |
| Tubby C-terminal domain-like | 0 | Direct |
| Translational machinery components | 0 | Direct |
| R3H domain | 0 | Direct |
| Nucleotidyltransferase | 0 | Direct |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| Ferritin-like | 0 | Direct |
| MgtE membrane domain-like | 0 | Direct |
| Band 7/SPFH domain | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Hypothetical protein c14orf129, hspc210 | 0 | Direct |
| Intermediate filament protein, coiled coil region | 0 | Direct |
| 2Fe-2S ferredoxin-like | 0 | Direct |
| Galactose oxidase, central domain | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| HSP20-like chaperones | 0 | Direct |
| Families 57/38 glycoside transferase middle domain | 0 | Direct |
| Tim10-like | 0 | Direct |
| CBD9-like | 0 | Direct |
| Cullin repeat-like | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| PYP-like sensor domain (PAS domain) | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| t-snare proteins | 0 | Direct |
| PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | Direct |
| GAS2 domain-like | 0 | Direct |
| Diaminopimelate epimerase-like | 0 | Direct |
| CO dehydrogenase ISP C-domain like | 0 | Direct |
| beta-lactamase/transpeptidase-like | 0 | Direct |
| Periplasmic binding protein-like II | 0 | Direct |
| PABC (PABP) domain | 0 | Direct |
| Rudiment single hybrid motif | 0 | Direct |
| RBP11-like subunits of RNA polymerase | 0 | Direct |
| TK C-terminal domain-like | 0 | Direct |
| Outer arm dynein light chain 1 | 0 | Direct |
| SMAD/FHA domain | 0 | Direct |
| Carbohydrate phosphatase | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| JAB1/MPN domain | 0 | Direct |
| Restriction endonuclease-like | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| Kringle-like | 0 | Direct |
| Arginase/deacetylase | 0 | Direct |
| HMG-box | 0 | Direct |
| Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
| S-adenosylmethionine synthetase | 0 | Direct |
| GAT-like domain | 0 | Direct |
| MIR domain | 0 | Direct |
| Molybdenum cofactor-binding domain | 0 | Direct |
| SPOC domain-like | 0 | Direct |
| SAND domain-like | 0 | Direct |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| GroES-like | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | Direct |
| VPS9 domain | 0 | Direct |
| ClpP/crotonase | 0 | Direct |
| FtsH protease domain-like | 0 | Direct |
| Citrate synthase | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Purine and uridine phosphorylases | 0 | Direct |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| Nucleoside diphosphate kinase, NDK | 0 | Direct |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | Direct |
| Ribosomal protein L1 | 0 | Direct |
| Second domain of FERM | 0 | Direct |
| ADP-ribosylation | 0 | Direct |
| Annexin | 0 | Direct |
| Calcium-dependent phosphotriesterase | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| ARID-like | 0 | Direct |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
| Ribosomal protein S10 | 0 | Direct |
| YWTD domain | 0 | Direct |
| alpha-catenin/vinculin-like | 0 | Direct |
| Carboxypeptidase regulatory domain-like | 0 | Direct |
| Oxysterol-binding protein-like | 0 | Direct |
| Radical SAM enzymes | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| HCP-like | 0 | Direct |
| HSP40/DnaJ peptide-binding domain | 0 | Direct |
| FF domain | 0 | Direct |
| MOSC N-terminal domain-like | 0 | Direct |
| Acyl-CoA dehydrogenase NM domain-like | 0 | Direct |
| lambda repressor-like DNA-binding domains | 0 | Direct |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | Direct |
| AN1-like Zinc finger | 0 | Direct |
| Terpenoid synthases | 0 | Direct |
| L-aspartase-like | 0 | Direct |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
| Fibrinogen C-terminal domain-like | 0 | Direct |
| Tubulin nucleotide-binding domain-like | 0 | Direct |
| Proton glutamate symport protein | 0 | Direct |
| Integrin domains | 0 | Direct |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
| PIN domain-like | 0 | Direct |
| DEATH domain | 0 | Direct |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | Direct |
| Zn-binding ribosomal proteins | 0 | Direct |
| dsRNA-binding domain-like | 0 | Direct |
| GroEL-intermediate domain like | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| ISP domain | 0 | Direct |
| PHM/PNGase F | 0 | Direct |
| PreATP-grasp domain | 0 | Direct |
| WWE domain | 0 | Direct |
| Class II aaRS ABD-related | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| CRAL/TRIO N-terminal domain | 0 | Direct |
| GHMP Kinase, C-terminal domain | 0 | Direct |
| Type II DNA topoisomerase | 0 | Direct |
| SAICAR synthase-like | 0 | Direct |
| alpha/beta knot | 0 | Direct |
| Elafin-like | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | Direct |
| Hect, E3 ligase catalytic domain | 0 | Direct |
| Aquaporin-like | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| Single hybrid motif | 0 | Direct |
| Cytochrome c | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| Alpha-L RNA-binding motif | 0 | Direct |
| Pepsin inhibitor-3 | 0 | Direct |
| Chromo domain-like | 0 | Direct |
| ENTH/VHS domain | 0 | Direct |
| Activating enzymes of the ubiquitin-like proteins | 0 | Direct |
| Protease propeptides/inhibitors | 0 | Direct |
| Cystatin/monellin | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| eIF4e-like | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
| PGBD-like | 0 | Direct |
| MFPT repeat-like | 0 | Direct |
| Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
| Cdc48 domain 2-like | 0 | Direct |
| Cadherin-like | 0 | Direct |
| SCP-like | 0 | Direct |
| Hormone receptor domain | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| PEBP-like | 0 | Direct |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0 | Direct |
| Blood coagulation inhibitor (disintegrin) | 0 | Direct |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| Ribosomal proteins S24e, L23 and L15e | 0 | Direct |
| Glutathione synthetase ATP-binding domain-like | 0 | Direct |
| Clc chloride channel | 0 | Direct |
| Mitochondrial carrier | 0 | Direct |
| Nucleoporin domain | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
| Carbonic anhydrase | 0 | Direct |
| SIS domain | 0 | Direct |
| Composite domain of metallo-dependent hydrolases | 0 | Direct |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
| Sec7 domain | 0 | Direct |
| P-loop containing nucleoside triphosphate hydrolases | 0.0000002643 | Direct |
| PH domain-like | 0.0000866 | Direct |
| Histone-fold | 0.000196 | Direct |
| Protein kinase-like (PK-like) | 0.00946 | Inherited |
| PDZ domain-like | 0.01494 | Inherited |
| Nucleic acid-binding proteins | 0.02328 | Inherited |
| Periplasmic binding protein-like I | 0.02382 | Inherited |
| TPR-like | 0.0244 | Inherited |
| "Winged helix" DNA-binding domain | 0.0259 | Inherited |
| PapD-like | 0.03966 | Inherited |
| WD40 repeat-like | 0.05061 | Inherited |
| ARM repeat | 0.05166 | Inherited |
| SH2 domain | 0.05667 | Inherited |
| Homeodomain-like | 0.07674 | Inherited |
| Calponin-homology domain, CH-domain | 0.07955 | Inherited |
| Acetyl-CoA synthetase-like | 0.07955 | Inherited |
| Cyclin-like | 0.08784 | Inherited |
| CCCH zinc finger | 0.09686 | Inherited |
| EGF/Laminin | 0.09932 | Inherited |
| Translation proteins | 0.118 | Inherited |
| Galactose-binding domain-like | 0.1258 | Inherited |
| Ankyrin repeat | 0.13 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.1471 | Inherited |
| Nucleotide cyclase | 0.1471 | Inherited |
| ABC transporter transmembrane region | 0.1471 | Inherited |
| RNI-like | 0.1551 | Inherited |
| Calcium ATPase, transmembrane domain M | 0.1575 | Inherited |
| Regulator of G-protein signaling, RGS | 0.1737 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1737 | Inherited |
| Class II aaRS and biotin synthetases | 0.1912 | Inherited |
| Calcium ATPase, transduction domain A | 0.1912 | Inherited |
| SH3-domain | 0.1968 | Inherited |
| E set domains | 0.1994 | Inherited |
| Quinoprotein alcohol dehydrogenase-like | 0.21 | Inherited |
| WW domain | 0.2311 | Inherited |
| DBL homology domain (DH-domain) | 0.2311 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.232 | Inherited |
| (Trans)glycosidases | 0.2768 | Inherited |
| Cytochrome P450 | 0.2768 | Inherited |
| Multidrug resistance efflux transporter EmrE | 0.2788 | Inherited |
| BRCT domain | 0.2877 | Inherited |
| Bromodomain | 0.3057 | Inherited |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.3057 | Inherited |
| Nucleotidylyl transferase | 0.3302 | Inherited |
| POZ domain | 0.3322 | Inherited |
| SNARE-like | 0.3344 | Inherited |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.3398 | Inherited |
| Cysteine proteinases | 0.3412 | Inherited |
| RNA-binding domain, RBD | 0.3439 | Inherited |
| Ribosomal protein S5 domain 2-like | 0.3501 | Inherited |
| Lipocalins | 0.3538 | Inherited |
| SAM/Pointed domain | 0.3538 | Inherited |
| Translation proteins SH3-like domain | 0.4022 | Inherited |
| Cation efflux protein transmembrane domain-like | 0.4022 | Inherited |
| Acid proteases | 0.4321 | Inherited |
| FKBP-like | 0.452 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.453 | Inherited |
| Cysteine-rich domain | 0.4595 | Inherited |
| Ubiquitin-like | 0.4636 | Inherited |
| FYVE/PHD zinc finger | 0.4655 | Inherited |
| HAD-like | 0.4845 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.4891 | Inherited |
| DHS-like NAD/FAD-binding domain | 0.5241 | Inherited |
| Myosin rod fragments | 0.5241 | Inherited |
| PRTase-like | 0.5241 | Inherited |
| Riboflavin synthase domain-like | 0.5722 | Inherited |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.5722 | Inherited |
| Calpain large subunit, middle domain (domain III) | 0.5722 | Inherited |
| Cystine-knot cytokines | 0.5843 | Inherited |
| Sm-like ribonucleoproteins | 0.5843 | Inherited |
| FAD-linked reductases, C-terminal domain | 0.5843 | Inherited |
| Voltage-gated potassium channels | 0.6176 | Inherited |
| Seven-hairpin glycosidases | 0.6218 | Inherited |
| FAD/NAD(P)-binding domain | 0.6235 | Inherited |
| SET domain | 0.6299 | Inherited |
| Growth factor receptor domain | 0.6384 | Inherited |
| UBC-like | 0.6536 | Inherited |
| Clavaminate synthase-like | 0.667 | Inherited |
| KA1-like | 0.6779 | Inherited |
| Lipovitellin-phosvitin complex, superhelical domain | 0.6779 | Inherited |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.6779 | Inherited |
| Nucleotide-binding domain | 0.6779 | Inherited |
| Osmotin, thaumatin-like protein | 0.6779 | Inherited |
| MFS general substrate transporter | 0.686 | Inherited |
| GTPase activation domain, GAP | 0.7275 | Inherited |
| 4Fe-4S ferredoxins | 0.7385 | Inherited |
| S15/NS1 RNA-binding domain | 0.7385 | Inherited |
| Frizzled cysteine-rich domain | 0.7385 | Inherited |
| GST C-terminal domain-like | 0.7642 | Inherited |
| PAZ domain | 0.7985 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.8019 | Inherited |
| Ribonuclease H-like | 0.8027 | Inherited |
| MIT domain | 0.8035 | Inherited |
| ADC-like | 0.8035 | Inherited |
| alpha/beta-Hydrolases | 0.8132 | Inherited |
| Fibronectin type III | 0.8595 | Inherited |
| Leucine zipper domain | 0.8992 | Inherited |
| UBA-like | 0.9103 | Inherited |
| EF-hand | 0.9132 | Inherited |
| DNA/RNA polymerases | 0.9644 | Inherited |
| p53-like transcription factors | 0.973 | Inherited |
| Ribonuclease PH domain 2-like | 0.9747 | Inherited |
| beta-beta-alpha zinc fingers | 0.997 | Inherited |
| Immunoglobulin | 0.9996 | Inherited |
| Thioredoxin-like | 1 | Inherited |
| Saposin | 1 | Inherited |
| Bet v1-like | 1 | Inherited |
| Nuclear receptor ligand-binding domain | 1 | Inherited |
| CoA-dependent acyltransferases | 1 | Inherited |
| B-box zinc-binding domain | 1 | Inherited |
| Eukaryotic type KH-domain (KH-domain type I) | 1 | Inherited |
| Cyclophilin-like | 1 | Inherited |
| F-box domain | 1 | Inherited |
| Family A G protein-coupled receptor-like | 1 | Inherited |
| Ligand-binding domain in the NO signalling and Golgi transport | 1 | Inherited |
| RING/U-box | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| Cyclin | 0 | DIRECT |
| Hsp90 middle domain | 0 | DIRECT |
| Clathrin adaptor core protein | 0 | DIRECT |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | DIRECT |
| FHA domain | 0 | DIRECT |
| XPF/Rad1/Mus81 nuclease | 0 | DIRECT |
| beta-Lactamase/D-ala carboxypeptidase | 0 | DIRECT |
| CoA-binding domain | 0 | DIRECT |
| NHL repeat | 0 | DIRECT |
| Class I aldolase | 0 | DIRECT |
| BC C-terminal domain-like | 0 | DIRECT |
| alpha-catenin/vinculin | 0 | DIRECT |
| Ribosomal protein L1 | 0 | DIRECT |
| Subtilases | 0 | DIRECT |
| HMG-box | 0 | DIRECT |
| LEM domain | 0 | DIRECT |
| 1,3-glucuronyltransferase | 0 | DIRECT |
| Second domain of FERM | 0 | DIRECT |
| Phosphatidylethanolamine binding protein | 0 | DIRECT |
| RNA-polymerase beta | 0 | DIRECT |
| Calcium ATPase, transmembrane domain M | 0 | DIRECT |
| Ribokinase-like | 0 | DIRECT |
| Complement control module/SCR domain | 0 | DIRECT |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| MOSC N-terminal domain-like | 0 | DIRECT |
| Biotinyl/lipoyl-carrier proteins and domains | 0 | DIRECT |
| Glycerophosphoryl diester phosphodiesterase | 0 | DIRECT |
| Biotin dependent carboxylase carboxyltransferase domain | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), catalytic domain | 0 | DIRECT |
| YbiA-like | 0 | DIRECT |
| Type II chitinase | 0 | DIRECT |
| Troponin I | 0 | DIRECT |
| DPP6 catalytic domain-like | 0 | DIRECT |
| alpha-mannosidase, domain 2 | 0 | DIRECT |
| Fatty acid binding protein-like | 0 | DIRECT |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | DIRECT |
| Phosphoribosyltransferases (PRTases) | 0 | DIRECT |
| Myotubularin-like phosphatases | 0 | DIRECT |
| Erythroid transcription factor GATA-1 | 0 | DIRECT |
| Mammalian PLC | 0 | DIRECT |
| ets domain | 0 | DIRECT |
| DEATH domain, DD | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| Poly(A) polymerase, PAP, C-terminal domain | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| AMPK-beta glycogen binding domain-like | 0 | DIRECT |
| Formate/glycerate dehydrogenases, NAD-domain | 0 | DIRECT |
| Thyroglobulin type-1 domain | 0 | DIRECT |
| Aminoacid dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Lactate & malate dehydrogenases, C-terminal domain | 0 | DIRECT |
| Nucleoside diphosphate kinase, NDK | 0 | DIRECT |
| PDEase | 0 | DIRECT |
| Adenosine/AMP deaminase | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain | 0 | DIRECT |
| BC ATP-binding domain-like | 0 | DIRECT |
| Hydantoinase (dihydropyrimidinase), catalytic domain | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| Matrix metalloproteases, catalytic domain | 0 | DIRECT |
| Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
| IF2B-like | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | DIRECT |
| Nucleosome core histones | 0 | DIRECT |
| Pyk2-associated protein beta ARF-GAP domain | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| Ubiquitin activating enzymes (UBA) | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| SAND domain | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
| Calpain large subunit, catalytic domain (domain II) | 0 | DIRECT |
| Proprotein convertase P-domain | 0 | DIRECT |
| Single strand DNA-binding domain, SSB | 0 | DIRECT |
| 28-residue LRR | 0 | DIRECT |
| Crotonase-like | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| FtsH protease domain-like | 0 | DIRECT |
| Histone deacetylase, HDAC | 0 | DIRECT |
| Methionine aminopeptidase, insert domain | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| HAT/Suf repeat | 0 | DIRECT |
| AAT-like | 0 | DIRECT |
| BAR domain | 0 | DIRECT |
| Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| Sec63 N-terminal domain | 0 | DIRECT |
| Acireductone dioxygenase | 0 | DIRECT |
| Armadillo repeat | 0 | DIRECT |
| a tRNA synthase domain | 0 | DIRECT |
| Reductases | 0 | DIRECT |
| ARID domain | 0 | DIRECT |
| GYF domain | 0 | DIRECT |
| Chaperone J-domain | 0 | DIRECT |
| Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| PurM N-terminal domain-like | 0 | DIRECT |
| Translational machinery components | 0 | DIRECT |
| Linker histone H1/H5 | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| CO dehydrogenase flavoprotein N-terminal domain-like | 0 | DIRECT |
| Poly(A) polymerase, PAP, N-terminal domain | 0 | DIRECT |
| Sir2 family of transcriptional regulators | 0 | DIRECT |
| Hypothetical protein c14orf129, hspc210 | 0 | DIRECT |
| POU-specific domain | 0 | DIRECT |
| PhzC/PhzF-like | 0 | DIRECT |
| Chromo domain | 0 | DIRECT |
| BEACH domain | 0 | DIRECT |
| SAM (sterile alpha motif) domain | 0 | DIRECT |
| Inositol polyphosphate kinase (IPK) | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | DIRECT |
| Pleckstrin-homology domain (PH domain) | 0 | DIRECT |
| Hydantoinase (dihydropyrimidinase) | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| PDZ domain | 0 | DIRECT |
| Actin/HSP70 | 0 | DIRECT |
| RhoGDI-like | 0 | DIRECT |
| Acylamino-acid-releasing enzyme, C-terminal donain | 0 | DIRECT |
| D-aminoacid oxidase, N-terminal domain | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| Filamin repeat (rod domain) | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| Sec7 domain | 0 | DIRECT |
| Rap/Ran-GAP | 0 | DIRECT |
| Bactericidal permeability-increasing protein, BPI | 0 | DIRECT |
| cAMP-binding domain | 0 | DIRECT |
| Surp module (SWAP domain) | 0 | DIRECT |
| AN1-like Zinc finger | 0 | DIRECT |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | DIRECT |
| Gamma-glutamyltranspeptidase-like | 0 | DIRECT |
| Anticodon-binding domain of Class II aaRS | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| DNA gyrase/MutL, second domain | 0 | DIRECT |
| Cytoplasmic domain of inward rectifier potassium channel | 0 | DIRECT |
| WWE domain | 0 | DIRECT |
| Chitinase insertion domain | 0 | DIRECT |
| Skp1 dimerisation domain-like | 0 | DIRECT |
| Laminin G-like module | 0 | DIRECT |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | DIRECT |
| HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
| UDP-glucose pyrophosphorylase | 0 | DIRECT |
| CAT-like | 0 | DIRECT |
| Sec63 C-terminal domain-like | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Tetraspanin | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Protein prenyltransferases | 0 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0 | DIRECT |
| Acyl-carrier protein (ACP) | 0 | DIRECT |
| beta 1,4 galactosyltransferase (b4GalT1) | 0 | DIRECT |
| UBA domain | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| DNA repair protein MutS, domain III | 0 | DIRECT |
| Pepsin inhibitor-3 | 0 | DIRECT |
| alpha-mannosidase, C-terminal domain | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| COMT-like | 0 | DIRECT |
| Type II DNA topoisomerase | 0 | DIRECT |
| Hexokinase | 0 | DIRECT |
| GAS2 domain | 0 | DIRECT |
| Double-stranded RNA-binding domain (dsRBD) | 0 | DIRECT |
| YWTD domain | 0 | DIRECT |
| Class I glutamine amidotransferases (GAT) | 0 | DIRECT |
| Amylase, catalytic domain | 0 | DIRECT |
| Elafin-like | 0 | DIRECT |
| L-aminoacid/polyamine oxidase | 0 | DIRECT |
| NTF2-like | 0 | DIRECT |
| Intermediate filament protein, coiled coil region | 0 | DIRECT |
| Regulator of G-protein signaling, RGS | 0 | DIRECT |
| HEAT repeat | 0 | DIRECT |
| Cofilin-like | 0 | DIRECT |
| Heme-dependent catalases | 0 | DIRECT |
| Tubulin, C-terminal domain | 0 | DIRECT |
| Tubulin, GTPase domain | 0 | DIRECT |
| Poly(A) polymerase, PAP, middle domain | 0 | DIRECT |
| DNA gyrase/MutL, N-terminal domain | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Anticodon-binding domain | 0 | DIRECT |
| Glycosyl transferases group 1 | 0 | DIRECT |
| Quinoprotein alcohol dehydrogenase-like | 0 | DIRECT |
| VHS domain | 0 | DIRECT |
| DPP6 N-terminal domain-like | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| Glycolipid transfer protein, GLTP | 0 | DIRECT |
| CO dehydrogenase ISP C-domain like | 0 | DIRECT |
| Doublecortin (DC) | 0 | DIRECT |
| S-adenosylmethionine synthetase | 0 | DIRECT |
| Oxysterol-binding protein | 0 | DIRECT |
| PABC (PABP) domain | 0 | DIRECT |
| Ran binding protein zinc finger-like | 0 | DIRECT |
| DEP domain | 0 | DIRECT |
| Phosphotyrosine-binding domain (PTB) | 0 | DIRECT |
| Carbonic anhydrase | 0 | DIRECT |
| Peptidylglycine alpha-hydroxylating monooxygenase, PHM | 0 | DIRECT |
| Sterol carrier protein, SCP | 0 | DIRECT |
| Arylsulfatase | 0 | DIRECT |
| Band 7/SPFH domain | 0 | DIRECT |
| Ribonucleotide reductase-like | 0 | DIRECT |
| YicI catalytic domain-like | 0 | DIRECT |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | DIRECT |
| Myeloperoxidase-like | 0 | DIRECT |
| Arfaptin, Rac-binding fragment | 0 | DIRECT |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0 | DIRECT |
| Alcohol dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Cdc48 domain 2-like | 0 | DIRECT |
| PUA domain | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| LDH N-terminal domain-like | 0 | DIRECT |
| t-snare proteins | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0 | DIRECT |
| Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
| WGR domain | 0 | DIRECT |
| HCDH C-domain-like | 0 | DIRECT |
| Citrate synthase | 0 | DIRECT |
| L30e/L7ae ribosomal proteins | 0 | DIRECT |
| Regulator of chromosome condensation RCC1 | 0 | DIRECT |
| HD domain | 0 | DIRECT |
| Purine and uridine phosphorylases | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0 | DIRECT |
| Epoxide hydrolase | 0 | DIRECT |
| PLC-like (P variant) | 0 | DIRECT |
| First domain of FERM | 0 | DIRECT |
| La domain | 0 | DIRECT |
| Tim10/DDP | 0 | DIRECT |
| Internalin LRR domain | 0 | DIRECT |
| Cadherin | 0 | DIRECT |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | DIRECT |
| Glutaminase | 0 | DIRECT |
| Trunk domain of Sec23/24 | 0 | DIRECT |
| alpha-Amylases, C-terminal beta-sheet domain | 0 | DIRECT |
| LysM domain | 0 | DIRECT |
| 5' to 3' exonuclease catalytic domain | 0 | DIRECT |
| LacY-like proton/sugar symporter | 0 | DIRECT |
| Glycerol kinase | 0 | DIRECT |
| alpha-mannosidase | 0 | DIRECT |
| YihX-like | 0 | DIRECT |
| Translation initiation factor eIF4e | 0 | DIRECT |
| RecA protein-like (ATPase-domain) | 0 | DIRECT |
| Pancreatic carboxypeptidase, activation domain | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | DIRECT |
| Mitochondrial carrier | 0 | DIRECT |
| Thiolase-related | 0 | DIRECT |
| MFPT repeat | 0 | DIRECT |
| PaaI/YdiI-like | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| Pancreatic carboxypeptidases | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| Glycogenin | 0 | DIRECT |
| U-box | 0 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Arginine methyltransferase | 0 | DIRECT |
| Hedgehog C-terminal (Hog) autoprocessing domain | 0 | DIRECT |
| Insulin-like | 0 | DIRECT |
| Ras-binding domain, RBD | 0 | DIRECT |
| SWIRM domain | 0 | DIRECT |
| Cell cycle control phosphatase, catalytic domain | 0 | DIRECT |
| Adenain-like | 0 | DIRECT |
| Brix domain | 0 | DIRECT |
| RNA editing terminal uridyl transferase 2, RET2, domain 2 | 0 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| Proteasome subunits | 0 | DIRECT |
| Phosphate binding protein-like | 0 | DIRECT |
| Profilin (actin-binding protein) | 0 | DIRECT |
| RNA-polymerase beta-prime | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | DIRECT |
| Polo-box duplicated region | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| D-aminoacid oxidase-like | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| acyl-CoA oxidase C-terminal domains | 0 | DIRECT |
| BC N-terminal domain-like | 0 | DIRECT |
| Aquaporin-like | 0 | DIRECT |
| Ribosomal protein L18 and S11 | 0 | DIRECT |
| GHMP Kinase, N-terminal domain | 0 | DIRECT |
| Acyl-CoA thioesterase | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| Inositol monophosphatase/fructose-1,6-bisphosphatase-like | 0 | DIRECT |
| AlkB-like | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| PDI-like | 0 | DIRECT |
| Clc chloride channel | 0 | DIRECT |
| Ribosomal protein S10 | 0 | DIRECT |
| Spectrin repeat | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | DIRECT |
| Carboxypeptidase regulatory domain | 0 | DIRECT |
| Alcohol dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| ATP-dependent protease Lon (La), catalytic domain | 0 | DIRECT |
| Ngr ectodomain-like | 0 | DIRECT |
| Reprolysin-like | 0 | DIRECT |
| SMAD domain | 0 | DIRECT |
| HSP20 | 0 | DIRECT |
| PEP carboxykinase C-terminal domain | 0 | DIRECT |
| Clathrin coat assembly domain | 0 | DIRECT |
| Third domain of FERM | 0 | DIRECT |
| MIF4G domain-like | 0 | DIRECT |
| Choline kinase | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
| Annexin | 0 | DIRECT |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
| Class II glutamine amidotransferases | 0 | DIRECT |
| Paired domain | 0 | DIRECT |
| Small-conductance potassium channel | 0 | DIRECT |
| MutT-like | 0 | DIRECT |
| SCF ubiquitin ligase complex WHB domain | 0 | DIRECT |
| p120GAP domain-like | 0 | DIRECT |
| Poly(ADP-ribose) polymerase, C-terminal domain | 0 | DIRECT |
| Hect, E3 ligase catalytic domain | 0 | DIRECT |
| CRAL/TRIO N-terminal domain | 0 | DIRECT |
| Cullin repeat | 0 | DIRECT |
| PurM C-terminal domain-like | 0 | DIRECT |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | DIRECT |
| EGF-type module | 0 | DIRECT |
| CUT domain | 0 | DIRECT |
| acyl-CoA oxidase N-terminal domains | 0 | DIRECT |
| Hormone receptor domain | 0 | DIRECT |
| NOL1/NOP2/sun | 0 | DIRECT |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | DIRECT |
| Molybdenum cofactor-binding domain | 0 | DIRECT |
| Fibrinogen C-terminal domain-like | 0 | DIRECT |
| Ferredoxin reductase FAD-binding domain-like | 0 | DIRECT |
| GAPDH-like | 0 | DIRECT |
| Tandem AAA-ATPase domain | 0.0004482 | DIRECT |
| Protein kinases, catalytic subunit | 0.02024 | INHERITED FROM: chemical response variant || positive chemotaxis variant || protein phosphorylation variant || metal response variant || aldicarb response variant || octanol chemotaxis defective || protein modification variant || drug induced gene expression variant || protein expression variant || conflicting sensory integration variant || copper response variant || protein phosphorylation reduced || anoxia resistant || second messenger mediated signaling variant || oxygen response variant || egg laying response to food variant || kinase activity reduced || pathogen induced gene expression variant || alkaline pH chemotaxis variant || protein subcellular localization variant || lipid synthesis increased |
| ABC transporter ATPase domain-like | 0.0467 | INHERITED FROM: colchicine hypersensitive || metal response variant || cadmium response variant || RNAi response variant |
| Homeodomain | 0.04705 | INHERITED FROM: level of transgene expression variant || sexually dimorphic physiology variant || ectopic expression transgene || organism metabolism processing variant || carbon dioxide response variant || carbon dioxide avoidance variant |
| G proteins | 0.04767 | INHERITED FROM: protein phosphorylation variant || aldicarb response variant || chemosensory response variant || drug induced gene expression variant || organism metabolism processing variant || protein metabolism variant || fat content variant || organism environmental stimulus response variant || bacterially unswollen || chemotaxis variant || osmotic integrity variant || carbon dioxide response variant || carbon dioxide avoidance variant || protein subcellular localization variant |
| WD40-repeat | 0.06137 | INHERITED FROM: dauer defective || organism metabolism processing variant || osmotic avoidance variant || antimicrobial gene expression variant || late larval arrest || protein aggregation induced behavior variant |
| L-arabinose binding protein-like | 0.07934 | INHERITED FROM: chemical response variant || magnesium chemotaxis defective || cation positive chemotaxis variant || bromide chemotaxis variant || chemosensory response variant || anion positive chemotaxis variant || anion positive chemotaxis defective || iodide chemotaxis defective || cation positive chemotaxis defective || lithium chemotaxis defective || organism environmental stimulus response variant || chemotaxis variant || alkaline pH chemotaxis variant || bromide chemotaxis defective || iodide chemotaxis variant |
| SH2 domain | 0.08304 | INHERITED FROM: protein expression reduced || protein expression variant || level of protein expression variant |
| MSP-like | 0.08306 | INHERITED FROM: larval growth variant || slow growth || dauer lifespan variant || dauer lifespan extended || dauer metabolism variant || fat content variant || lipid metabolism variant || larval arrest || developmental growth variant |
| Acetyl-CoA synthetase-like | 0.09502 | INHERITED FROM: lipid metabolism variant |
| Calponin-homology domain, CH-domain | 0.09502 | INHERITED FROM: protein degradation variant |
| Canonical RBD | 0.1139 | INHERITED FROM: RNA expression variant || organism metabolism processing variant || mRNA export variant || RNA processing variant || no induction of antimicrobial peptide expression after infection || starvation induced apoptosis variant || antimicrobial gene expression variant || late larval arrest || innate immune response variant || sick |
| CCCH zinc finger | 0.1139 | INHERITED FROM: ectopic expression transgene || transgene expression variant || mRNA expression ectopic || gene expression variant |
| Tetratricopeptide repeat (TPR) | 0.1578 | INHERITED FROM: organism metabolism processing variant |
| Cold shock DNA-binding domain-like | 0.1634 | INHERITED FROM: mRNA surveillance defective || nonsense mRNA accumulation || sick |
| Adenylyl and guanylyl cyclase catalytic domain | 0.182 | INHERITED FROM: positive chemotaxis variant || AWC odorant chemotaxis variant || magnesium chemotaxis defective || cation positive chemotaxis variant || bromide chemotaxis variant || chemosensory response variant || AWC odorant chemotaxis defective || anion positive chemotaxis defective || iodide chemotaxis defective || osmotic avoidance variant || diacetyl chemotaxis variant || second messenger mediated signaling variant || cation positive chemotaxis defective || lithium chemotaxis defective || organism environmental stimulus response variant || chemotaxis variant || carbon dioxide response variant || alkaline pH chemotaxis variant || bromide chemotaxis defective || iodide chemotaxis variant |
| HLH, helix-loop-helix DNA-binding domain | 0.182 | INHERITED FROM: gene expression level reduced || RNA expression variant || ectopic expression transgene || hypoxia response variant || lysine chemotaxis defective |
| Ankyrin repeat | 0.2051 | INHERITED FROM: octanol chemotaxis defective || organism heat response variant || odorant negative chemotaxis defective || octanol chemotaxis variant |
| Calcium ATPase, transduction domain A | 0.2131 | INHERITED FROM: organism environmental stimulus response variant || drug hypersensitive || nicotine hypersensitive |
| ABC transporter transmembrane region | 0.239 | INHERITED FROM: colchicine hypersensitive || metal response variant || organism environmental stimulus response variant || cadmium response variant || RNAi response variant |
| Pepsin-like | 0.2542 | INHERITED FROM: protein interaction variant || protein protein interaction variant || organism metabolism processing variant || hypoosmotic shock hypersensitive || transgene expression variant || pattern of transgene expression variant || gene expression variant || transgene subcellular localization variant || protein aggregation variant || osmotic integrity variant |
| Elongation factors | 0.2542 | INHERITED FROM: protein phosphorylation variant || protein protein interaction variant || proteasome core activity variant || protein modification variant || protein phosphorylation increased || protein aggregation variant || mRNA levels reduced || mRNA levels increased |
| DBL homology domain (DH-domain) | 0.2542 | INHERITED FROM: aldicarb response variant || pathogen resistance increased || organism pathogen response variant || organism environmental stimulus response variant || bacterially unswollen |
| Extended PAW domain | 0.2542 | INHERITED FROM: protein interaction variant || protein protein interaction variant || pattern of transgene expression variant || transgene subcellular localization variant || protein aggregation variant |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.2542 | INHERITED FROM: hypoxia resistant || paraquat response variant || transgene expression increased || hypoxia response variant || organism metabolism processing variant || paraquat resistant || oxygen response variant || gene expression variant || antimicrobial gene expression variant || organism environmental stimulus response variant || innate immune response variant |
| WW domain | 0.2542 | INHERITED FROM: maintenance of gene silencing variant |
| Histone lysine methyltransferases | 0.2542 | INHERITED FROM: histone methylation variant || protein methylation variant || somatic transgene silencing variant || protein modification variant || mRNA expression variant || protein expression variant || ectopic expression transgene || maintenance of gene silencing variant || RNAi response variant || ectopic expression antibody || life span variant |
| SH3-domain | 0.2587 | INHERITED FROM: protein expression reduced || aldicarb response variant || protein expression variant |
| Dual specificity phosphatase-like | 0.2766 | INHERITED FROM: level of transgene expression variant || organism metabolism processing variant || gene expression variant || transgene expression reduced |
| Acetylcholinesterase-like | 0.2837 | INHERITED FROM: enzyme activity variant || enzyme activity reduced || acetylcholinesterase reduced || acetylcholinesterase activity variant |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.3014 | INHERITED FROM: organism environmental stimulus response variant || drug hypersensitive || nicotine hypersensitive |
| Bromodomain | 0.3296 | INHERITED FROM: drug adaptation variant || organism UV hypersensitive || anesthetic response variant || ethanol resistant || acute functional tolerance to alcohol defective || organism UV response variant || sick || anesthetic resistant || organism stress response variant |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 0.3296 | INHERITED FROM: fat content variant || lipid metabolism variant |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0.3296 | INHERITED FROM: aldicarb resistant || acetylcholinesterase inhibitor resistant |
| Multidrug efflux transporter AcrB transmembrane domain | 0.3316 | INHERITED FROM: embryo osmotic integrity defective early emb || egg integrity defective early emb || positive chemotaxis defective || chemotaxis variant || odorant positive chemotaxis defective || odorant chemosensory response variant |
| Extended AAA-ATPase domain | 0.3348 | INHERITED FROM: protein expression increased || spontaneous mutation rate increased || sick || life span variant |
| FAD/NAD-linked reductases, N-terminal and central domains | 0.3586 | INHERITED FROM: paraquat response variant || organism oxidative stress response variant || pesticide response variant |
| Cytochrome P450 | 0.3679 | INHERITED FROM: metal response variant || cadmium response variant |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.3911 | INHERITED FROM: protein protein interaction variant || pattern of transgene expression variant || protein aggregation variant || sick || pattern protein expression variant || protein subcellular localization variant || life span variant |
| Meta-cation ATPase, catalytic domain P | 0.3911 | INHERITED FROM: organism environmental stimulus response variant || nicotine hypersensitive |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.449 | INHERITED FROM: chemical response variant || drug response variant || hypoosmotic shock hypersensitive || DMPP response variant || mechanosensation variant || selenium response variant || organism environmental stimulus response variant || sodium chloride chemotaxis variant || nicotine resistant || aqueous chemosensory response variant || antihelmintic response variant || cholinergic agonist resistant |
| Pumilio repeat | 0.4617 | INHERITED FROM: protein expression ectopic |
| GABA-aminotransferase-like | 0.4617 | INHERITED FROM: fat content reduced |
| FKBP immunophilin/proline isomerase | 0.4754 | INHERITED FROM: protein interaction variant || protein protein interaction variant || pattern of transgene expression variant || transgene subcellular localization variant || protein aggregation variant |
| Cation efflux protein transmembrane domain-like | 0.5007 | INHERITED FROM: manganese toxicity resistant || manganese response variant || metal response variant || cadmium hypersensitive || cadmium response variant |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.5027 | INHERITED FROM: drug resistant || drug induced gene expression variant || nose touch variant || organism pathogen response variant || antimicrobial gene expression variant || odorant positive chemotaxis variant || odorant chemosensory response variant || protein subcellular localization variant |
| PHD domain | 0.532 | INHERITED FROM: protein methylation variant || organism UV hypersensitive || ectopic expression transgene || RNAi resistant || organism UV response variant || RNAi response variant |
| Pyridoxal-dependent decarboxylase | 0.5451 | INHERITED FROM: drug response variant || egg laying response to drug variant || carbon dioxide response variant || carbon dioxide avoidance variant |
| Myosin rod fragments | 0.5451 | INHERITED FROM: drug resistant |
| Glutathione S-transferase (GST), N-terminal domain | 0.5486 | INHERITED FROM: enzyme activity variant || paraquat response variant || enzyme activity reduced || cadmium hypersensitive || organism electrophilic stress hypersensitive || organism environmental stimulus response variant || cadmium response variant || organism heat hypersensitive || organism stress response variant |
| Nicotinic receptor ligand binding domain-like | 0.586 | INHERITED FROM: chemical response variant || drug response variant || hypoosmotic shock hypersensitive || DMPP response variant || mechanosensation variant || selenium response variant || organism environmental stimulus response variant || sodium chloride chemotaxis variant || nicotine resistant || aqueous chemosensory response variant || antihelmintic response variant || cholinergic agonist resistant |
| Myb/SANT domain | 0.5895 | INHERITED FROM: growth rate variant |
| Calpain large subunit, middle domain (domain III) | 0.5895 | INHERITED FROM: protein degradation variant || metabolic pathway variant || protein metabolism variant |
| Gastric lipase | 0.5895 | INHERITED FROM: fat content variant || lipid metabolism variant |
| I set domains | 0.591 | INHERITED FROM: protein degradation variant || aldicarb response variant || aldicarb resistant || metabolic pathway variant || growth rate variant || organism environmental stimulus response variant |
| Papain-like | 0.6162 | INHERITED FROM: protein interaction variant || protein protein interaction variant || organism metabolism processing variant || hypoosmotic shock hypersensitive || transgene expression variant || pattern of transgene expression variant || gene expression variant || protein aggregation variant || osmotic integrity variant |
| Class I alpha-1;2-mannosidase, catalytic domain | 0.6396 | INHERITED FROM: protein protein interaction variant || protein aggregation variant || extended life span |
| UBC-related | 0.6678 | INHERITED FROM: protein interaction variant || protein protein interaction variant || organism metabolism processing variant || transgene expression variant || pattern of transgene expression variant || gene expression variant || transgene subcellular localization variant || late larval arrest || protein aggregation variant |
| Synaptotagmin-like (S variant) | 0.6883 | INHERITED FROM: drug resistant || acetylcholinesterase inhibitor resistant || pattern protein expression variant || acetylcholinesterase inhibitor response variant || protein subcellular localization variant |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.693 | INHERITED FROM: organism pathogen response variant || pathogen susceptibility increased || organism environmental stimulus response variant || life span variant |
| Osmotin, thaumatin-like protein | 0.693 | INHERITED FROM: metal response variant || cadmium hypersensitive || cadmium response variant |
| Lipovitellin-phosvitin complex, superhelical domain | 0.693 | INHERITED FROM: organism pathogen response variant || pathogen susceptibility increased || organism environmental stimulus response variant || life span variant |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0.7191 | INHERITED FROM: protein interaction variant || protein protein interaction variant || organism metabolism processing variant || transgene expression variant || pattern of transgene expression variant || gene expression variant || protein aggregation variant |
| BTB/POZ domain | 0.7452 | INHERITED FROM: chemical response variant || resistant to protein aggregation induced paralysis || L1 arrest || early larval arrest || protein aggregation induced behavior variant || chemical hypersensitive |
| Frizzled cysteine-rich domain | 0.7512 | INHERITED FROM: antibody staining variant || transgene expression reduced |
| Transforming growth factor (TGF)-beta | 0.7512 | INHERITED FROM: level of transgene expression variant || levamisole response variant || nicotine response variant || drug response variant || transgene expression reduced |
| EF-hand modules in multidomain proteins | 0.7512 | INHERITED FROM: protein expression variant |
| Bacterial lipase | 0.8119 | INHERITED FROM: fat content variant || lipid metabolism variant |
| Cdc48 N-terminal domain-like | 0.8119 | INHERITED FROM: protein interaction variant || protein protein interaction variant || metabolic pathway variant || protein metabolism variant || protein aggregation variant |
| H-NOX domain | 0.8119 | INHERITED FROM: carbon dioxide response variant || carbon dioxide avoidance variant |
| MIT domain | 0.8119 | INHERITED FROM: protein interaction variant || protein protein interaction variant || protein aggregation variant |
| Ubiquitin-related | 0.8269 | INHERITED FROM: protein interaction variant || protein protein interaction variant || organism metabolism processing variant || hypersensitive to protein aggregation induced paralysis || transgene expression variant || protein aggregation variant |
| Voltage-gated potassium channels | 0.848 | INHERITED FROM: adrenergic receptor antagonist response variant || protein degradation variant || serotonin response variant || AWA odorant chemotaxis variant || protein metabolism variant || growth rate variant |
| FAD-linked reductases, N-terminal domain | 0.8574 | INHERITED FROM: shortened life span |
| PAZ domain | 0.8889 | INHERITED FROM: RNA expression variant || RNAi enhanced || siRNA expression variant || maintenance of gene silencing variant || 21U RNA expression variant || RNAi response variant || mRNA levels increased |
| LIM domain | 0.8935 | INHERITED FROM: protein expression reduced || protein degradation variant || level of protein expression variant |
| Fibronectin type III | 0.9172 | INHERITED FROM: protein degradation variant |
| Glutathione S-transferase (GST), C-terminal domain | 0.9362 | INHERITED FROM: enzyme activity variant || enzyme activity reduced || cadmium hypersensitive || organism electrophilic stress hypersensitive || cadmium response variant || organism stress response variant |
| Leucine zipper domain | 0.9363 | INHERITED FROM: level of transgene expression variant || pathogen susceptibility increased || pore forming toxin response variant || transgene expression reduced || mRNA levels reduced |
| DnaQ-like 3'-5' exonuclease | 0.942 | INHERITED FROM: RNAi response variant |
| Calmodulin-like | 0.9636 | INHERITED FROM: protein interaction variant || protein protein interaction variant || transgene subcellular localization variant || protein aggregation variant |
| Nuclear receptor ligand-binding domain | 0.9835 | INHERITED FROM: gene expression level reduced || dauer resistance to harsh conditions variant || SDS sensitive dauer || gene expression level high || fat content increased || lipid metabolism variant || transgene expression reduced |
| NagD-like | 0.9855 | INHERITED FROM: dauer formation variant || dauer constitutive |
| Ribonuclease PH domain 2-like | 0.9855 | INHERITED FROM: early larval arrest |
| Ribonuclease PH domain 1-like | 0.9855 | INHERITED FROM: early larval arrest |
| RING finger domain, C3HC4 | 1 | INHERITED FROM: protein interaction variant || protein protein interaction variant || organism metabolism processing variant || pattern of transgene expression variant || transgene subcellular localization variant || protein aggregation variant |
| C-type lectin domain | 1 | INHERITED FROM: pathogen induced death increased |
| Glutathione peroxidase-like | 1 | INHERITED FROM: paraquat response variant || pesticide response variant |
| F-box domain | 1 | INHERITED FROM: resistant to protein aggregation induced paralysis || protein aggregation induced behavior variant |
| Nuclear receptor | 1 | INHERITED FROM: gene expression level reduced || dauer resistance to harsh conditions variant || SDS sensitive dauer || gene expression level high || fat content increased || transgene expression reduced |
| B-box zinc-binding domain | 1 | INHERITED FROM: protein interaction variant || protein protein interaction variant || transgene expression variant || gene expression variant || transgene subcellular localization variant || protein aggregation variant |
| Cyclophilin (peptidylprolyl isomerase) | 1 | INHERITED FROM: protein interaction variant || protein protein interaction variant || transgene expression variant || pattern of transgene expression variant || transgene subcellular localization variant || protein aggregation variant |
| N-acetyl transferase, NAT | 1 | INHERITED FROM: ectopic expression transgene |
| Rhodopsin-like | 1 | INHERITED FROM: serotonin hypersensitive || biogenic amine receptor antagonist resistant || locomotion rate serotonin variant || male tail curling serotonin variant || serotonin response variant || aqueous adaptation defective || serotonin resistant || drug withdrawal response variant || organism pathogen response variant || serotonin induced fat reduction variant || egg laying response to drug variant || serotonin induced pumping variant |
| Choline/Carnitine O-acyltransferase | 1 | INHERITED FROM: fat content variant || lipid metabolism variant |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| Cyclin | 0 | Direct |
| Hsp90 middle domain | 0 | Direct |
| Clathrin adaptor core protein | 0 | Direct |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | Direct |
| FHA domain | 0 | Direct |
| XPF/Rad1/Mus81 nuclease | 0 | Direct |
| beta-Lactamase/D-ala carboxypeptidase | 0 | Direct |
| CoA-binding domain | 0 | Direct |
| NHL repeat | 0 | Direct |
| Class I aldolase | 0 | Direct |
| BC C-terminal domain-like | 0 | Direct |
| alpha-catenin/vinculin | 0 | Direct |
| Ribosomal protein L1 | 0 | Direct |
| Subtilases | 0 | Direct |
| HMG-box | 0 | Direct |
| LEM domain | 0 | Direct |
| 1,3-glucuronyltransferase | 0 | Direct |
| Second domain of FERM | 0 | Direct |
| Phosphatidylethanolamine binding protein | 0 | Direct |
| RNA-polymerase beta | 0 | Direct |
| Calcium ATPase, transmembrane domain M | 0 | Direct |
| Ribokinase-like | 0 | Direct |
| Complement control module/SCR domain | 0 | Direct |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | Direct |
| MOSC N-terminal domain-like | 0 | Direct |
| Biotinyl/lipoyl-carrier proteins and domains | 0 | Direct |
| Glycerophosphoryl diester phosphodiesterase | 0 | Direct |
| Biotin dependent carboxylase carboxyltransferase domain | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), catalytic domain | 0 | Direct |
| YbiA-like | 0 | Direct |
| Type II chitinase | 0 | Direct |
| Troponin I | 0 | Direct |
| DPP6 catalytic domain-like | 0 | Direct |
| alpha-mannosidase, domain 2 | 0 | Direct |
| Fatty acid binding protein-like | 0 | Direct |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | Direct |
| Phosphoribosyltransferases (PRTases) | 0 | Direct |
| Myotubularin-like phosphatases | 0 | Direct |
| Erythroid transcription factor GATA-1 | 0 | Direct |
| Mammalian PLC | 0 | Direct |
| ets domain | 0 | Direct |
| DEATH domain, DD | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| Poly(A) polymerase, PAP, C-terminal domain | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| AMPK-beta glycogen binding domain-like | 0 | Direct |
| Formate/glycerate dehydrogenases, NAD-domain | 0 | Direct |
| Thyroglobulin type-1 domain | 0 | Direct |
| Aminoacid dehydrogenase-like, C-terminal domain | 0 | Direct |
| Lactate & malate dehydrogenases, C-terminal domain | 0 | Direct |
| Nucleoside diphosphate kinase, NDK | 0 | Direct |
| PDEase | 0 | Direct |
| Adenosine/AMP deaminase | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain | 0 | Direct |
| BC ATP-binding domain-like | 0 | Direct |
| Hydantoinase (dihydropyrimidinase), catalytic domain | 0 | Direct |
| ALDH-like | 0 | Direct |
| Matrix metalloproteases, catalytic domain | 0 | Direct |
| Blood coagulation inhibitor (disintegrin) | 0 | Direct |
| IF2B-like | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | Direct |
| Nucleosome core histones | 0 | Direct |
| Pyk2-associated protein beta ARF-GAP domain | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| Ubiquitin activating enzymes (UBA) | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| SAND domain | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
| Calpain large subunit, catalytic domain (domain II) | 0 | Direct |
| Proprotein convertase P-domain | 0 | Direct |
| Single strand DNA-binding domain, SSB | 0 | Direct |
| 28-residue LRR | 0 | Direct |
| Crotonase-like | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
| FtsH protease domain-like | 0 | Direct |
| Histone deacetylase, HDAC | 0 | Direct |
| Methionine aminopeptidase, insert domain | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| HAT/Suf repeat | 0 | Direct |
| AAT-like | 0 | Direct |
| BAR domain | 0 | Direct |
| Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 0 | Direct |
| Sec63 N-terminal domain | 0 | Direct |
| Acireductone dioxygenase | 0 | Direct |
| Armadillo repeat | 0 | Direct |
| a tRNA synthase domain | 0 | Direct |
| Reductases | 0 | Direct |
| ARID domain | 0 | Direct |
| GYF domain | 0 | Direct |
| Chaperone J-domain | 0 | Direct |
| Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| PurM N-terminal domain-like | 0 | Direct |
| Translational machinery components | 0 | Direct |
| Linker histone H1/H5 | 0 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| CO dehydrogenase flavoprotein N-terminal domain-like | 0 | Direct |
| Poly(A) polymerase, PAP, N-terminal domain | 0 | Direct |
| Sir2 family of transcriptional regulators | 0 | Direct |
| Hypothetical protein c14orf129, hspc210 | 0 | Direct |
| POU-specific domain | 0 | Direct |
| PhzC/PhzF-like | 0 | Direct |
| Chromo domain | 0 | Direct |
| BEACH domain | 0 | Direct |
| SAM (sterile alpha motif) domain | 0 | Direct |
| Inositol polyphosphate kinase (IPK) | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | Direct |
| Pleckstrin-homology domain (PH domain) | 0 | Direct |
| Hydantoinase (dihydropyrimidinase) | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| PDZ domain | 0 | Direct |
| Actin/HSP70 | 0 | Direct |
| RhoGDI-like | 0 | Direct |
| Acylamino-acid-releasing enzyme, C-terminal donain | 0 | Direct |
| D-aminoacid oxidase, N-terminal domain | 0 | Direct |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | Direct |
| FF domain | 0 | Direct |
| Filamin repeat (rod domain) | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| Sec7 domain | 0 | Direct |
| Rap/Ran-GAP | 0 | Direct |
| Bactericidal permeability-increasing protein, BPI | 0 | Direct |
| cAMP-binding domain | 0 | Direct |
| Surp module (SWAP domain) | 0 | Direct |
| AN1-like Zinc finger | 0 | Direct |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
| Bacterial exopeptidase dimerisation domain | 0 | Direct |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | Direct |
| Gamma-glutamyltranspeptidase-like | 0 | Direct |
| Anticodon-binding domain of Class II aaRS | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| DNA gyrase/MutL, second domain | 0 | Direct |
| Cytoplasmic domain of inward rectifier potassium channel | 0 | Direct |
| WWE domain | 0 | Direct |
| Chitinase insertion domain | 0 | Direct |
| Skp1 dimerisation domain-like | 0 | Direct |
| Laminin G-like module | 0 | Direct |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | Direct |
| HSP40/DnaJ peptide-binding domain | 0 | Direct |
| UDP-glucose pyrophosphorylase | 0 | Direct |
| CAT-like | 0 | Direct |
| Sec63 C-terminal domain-like | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Tetraspanin | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Protein prenyltransferases | 0 | Direct |
| Transducin (alpha subunit), insertion domain | 0 | Direct |
| Acyl-carrier protein (ACP) | 0 | Direct |
| beta 1,4 galactosyltransferase (b4GalT1) | 0 | Direct |
| UBA domain | 0 | Direct |
| MIR domain | 0 | Direct |
| Proton glutamate symport protein | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| DNA repair protein MutS, domain III | 0 | Direct |
| Pepsin inhibitor-3 | 0 | Direct |
| alpha-mannosidase, C-terminal domain | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| COMT-like | 0 | Direct |
| Type II DNA topoisomerase | 0 | Direct |
| Hexokinase | 0 | Direct |
| GAS2 domain | 0 | Direct |
| Double-stranded RNA-binding domain (dsRBD) | 0 | Direct |
| YWTD domain | 0 | Direct |
| Class I glutamine amidotransferases (GAT) | 0 | Direct |
| Amylase, catalytic domain | 0 | Direct |
| Elafin-like | 0 | Direct |
| L-aminoacid/polyamine oxidase | 0 | Direct |
| NTF2-like | 0 | Direct |
| Intermediate filament protein, coiled coil region | 0 | Direct |
| Regulator of G-protein signaling, RGS | 0 | Direct |
| HEAT repeat | 0 | Direct |
| Cofilin-like | 0 | Direct |
| Heme-dependent catalases | 0 | Direct |
| Tubulin, C-terminal domain | 0 | Direct |
| Tubulin, GTPase domain | 0 | Direct |
| Poly(A) polymerase, PAP, middle domain | 0 | Direct |
| DNA gyrase/MutL, N-terminal domain | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Anticodon-binding domain | 0 | Direct |
| Glycosyl transferases group 1 | 0 | Direct |
| Quinoprotein alcohol dehydrogenase-like | 0 | Direct |
| VHS domain | 0 | Direct |
| DPP6 N-terminal domain-like | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| Glycolipid transfer protein, GLTP | 0 | Direct |
| CO dehydrogenase ISP C-domain like | 0 | Direct |
| Doublecortin (DC) | 0 | Direct |
| S-adenosylmethionine synthetase | 0 | Direct |
| Oxysterol-binding protein | 0 | Direct |
| PABC (PABP) domain | 0 | Direct |
| Ran binding protein zinc finger-like | 0 | Direct |
| DEP domain | 0 | Direct |
| Phosphotyrosine-binding domain (PTB) | 0 | Direct |
| Carbonic anhydrase | 0 | Direct |
| Peptidylglycine alpha-hydroxylating monooxygenase, PHM | 0 | Direct |
| Sterol carrier protein, SCP | 0 | Direct |
| Arylsulfatase | 0 | Direct |
| Band 7/SPFH domain | 0 | Direct |
| Ribonucleotide reductase-like | 0 | Direct |
| YicI catalytic domain-like | 0 | Direct |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | Direct |
| Myeloperoxidase-like | 0 | Direct |
| Arfaptin, Rac-binding fragment | 0 | Direct |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0 | Direct |
| Alcohol dehydrogenase-like, C-terminal domain | 0 | Direct |
| Cdc48 domain 2-like | 0 | Direct |
| PUA domain | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| LDH N-terminal domain-like | 0 | Direct |
| t-snare proteins | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0 | Direct |
| Cation efflux protein cytoplasmic domain-like | 0 | Direct |
| WGR domain | 0 | Direct |
| HCDH C-domain-like | 0 | Direct |
| Citrate synthase | 0 | Direct |
| L30e/L7ae ribosomal proteins | 0 | Direct |
| Regulator of chromosome condensation RCC1 | 0 | Direct |
| HD domain | 0 | Direct |
| Purine and uridine phosphorylases | 0 | Direct |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0 | Direct |
| Epoxide hydrolase | 0 | Direct |
| PLC-like (P variant) | 0 | Direct |
| First domain of FERM | 0 | Direct |
| La domain | 0 | Direct |
| Tim10/DDP | 0 | Direct |
| Internalin LRR domain | 0 | Direct |
| Cadherin | 0 | Direct |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | Direct |
| Glutaminase | 0 | Direct |
| Trunk domain of Sec23/24 | 0 | Direct |
| alpha-Amylases, C-terminal beta-sheet domain | 0 | Direct |
| LysM domain | 0 | Direct |
| 5' to 3' exonuclease catalytic domain | 0 | Direct |
| LacY-like proton/sugar symporter | 0 | Direct |
| Glycerol kinase | 0 | Direct |
| alpha-mannosidase | 0 | Direct |
| YihX-like | 0 | Direct |
| Translation initiation factor eIF4e | 0 | Direct |
| RecA protein-like (ATPase-domain) | 0 | Direct |
| Pancreatic carboxypeptidase, activation domain | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | Direct |
| Mitochondrial carrier | 0 | Direct |
| Thiolase-related | 0 | Direct |
| MFPT repeat | 0 | Direct |
| PaaI/YdiI-like | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| Pancreatic carboxypeptidases | 0 | Direct |
| Nop domain | 0 | Direct |
| Glycogenin | 0 | Direct |
| U-box | 0 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Arginine methyltransferase | 0 | Direct |
| Hedgehog C-terminal (Hog) autoprocessing domain | 0 | Direct |
| Insulin-like | 0 | Direct |
| Ras-binding domain, RBD | 0 | Direct |
| SWIRM domain | 0 | Direct |
| Cell cycle control phosphatase, catalytic domain | 0 | Direct |
| Adenain-like | 0 | Direct |
| Brix domain | 0 | Direct |
| RNA editing terminal uridyl transferase 2, RET2, domain 2 | 0 | Direct |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| Proteasome subunits | 0 | Direct |
| Phosphate binding protein-like | 0 | Direct |
| Profilin (actin-binding protein) | 0 | Direct |
| RNA-polymerase beta-prime | 0 | Direct |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | Direct |
| Polo-box duplicated region | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| D-aminoacid oxidase-like | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| acyl-CoA oxidase C-terminal domains | 0 | Direct |
| BC N-terminal domain-like | 0 | Direct |
| Aquaporin-like | 0 | Direct |
| Ribosomal protein L18 and S11 | 0 | Direct |
| GHMP Kinase, N-terminal domain | 0 | Direct |
| Acyl-CoA thioesterase | 0 | Direct |
| Integrin domains | 0 | Direct |
| Inositol monophosphatase/fructose-1,6-bisphosphatase-like | 0 | Direct |
| AlkB-like | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| PDI-like | 0 | Direct |
| Clc chloride channel | 0 | Direct |
| Ribosomal protein S10 | 0 | Direct |
| Spectrin repeat | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | Direct |
| Carboxypeptidase regulatory domain | 0 | Direct |
| Alcohol dehydrogenase-like, N-terminal domain | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| ATP-dependent protease Lon (La), catalytic domain | 0 | Direct |
| Ngr ectodomain-like | 0 | Direct |
| Reprolysin-like | 0 | Direct |
| SMAD domain | 0 | Direct |
| HSP20 | 0 | Direct |
| PEP carboxykinase C-terminal domain | 0 | Direct |
| Clathrin coat assembly domain | 0 | Direct |
| Third domain of FERM | 0 | Direct |
| MIF4G domain-like | 0 | Direct |
| Choline kinase | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
| Annexin | 0 | Direct |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
| Class II glutamine amidotransferases | 0 | Direct |
| Paired domain | 0 | Direct |
| Small-conductance potassium channel | 0 | Direct |
| MutT-like | 0 | Direct |
| SCF ubiquitin ligase complex WHB domain | 0 | Direct |
| p120GAP domain-like | 0 | Direct |
| Poly(ADP-ribose) polymerase, C-terminal domain | 0 | Direct |
| Hect, E3 ligase catalytic domain | 0 | Direct |
| CRAL/TRIO N-terminal domain | 0 | Direct |
| Cullin repeat | 0 | Direct |
| PurM C-terminal domain-like | 0 | Direct |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | Direct |
| EGF-type module | 0 | Direct |
| CUT domain | 0 | Direct |
| acyl-CoA oxidase N-terminal domains | 0 | Direct |
| Hormone receptor domain | 0 | Direct |
| NOL1/NOP2/sun | 0 | Direct |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | Direct |
| Molybdenum cofactor-binding domain | 0 | Direct |
| Fibrinogen C-terminal domain-like | 0 | Direct |
| Ferredoxin reductase FAD-binding domain-like | 0 | Direct |
| GAPDH-like | 0 | Direct |
| Tandem AAA-ATPase domain | 0.0004482 | Direct |
| Protein kinases, catalytic subunit | 0.02024 | Inherited |
| ABC transporter ATPase domain-like | 0.0467 | Inherited |
| Homeodomain | 0.04705 | Inherited |
| G proteins | 0.04767 | Inherited |
| WD40-repeat | 0.06137 | Inherited |
| L-arabinose binding protein-like | 0.07934 | Inherited |
| SH2 domain | 0.08304 | Inherited |
| MSP-like | 0.08306 | Inherited |
| Acetyl-CoA synthetase-like | 0.09502 | Inherited |
| Calponin-homology domain, CH-domain | 0.09502 | Inherited |
| Canonical RBD | 0.1139 | Inherited |
| CCCH zinc finger | 0.1139 | Inherited |
| Tetratricopeptide repeat (TPR) | 0.1578 | Inherited |
| Cold shock DNA-binding domain-like | 0.1634 | Inherited |
| Adenylyl and guanylyl cyclase catalytic domain | 0.182 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.182 | Inherited |
| Ankyrin repeat | 0.2051 | Inherited |
| Calcium ATPase, transduction domain A | 0.2131 | Inherited |
| ABC transporter transmembrane region | 0.239 | Inherited |
| Pepsin-like | 0.2542 | Inherited |
| Elongation factors | 0.2542 | Inherited |
| DBL homology domain (DH-domain) | 0.2542 | Inherited |
| Extended PAW domain | 0.2542 | Inherited |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.2542 | Inherited |
| WW domain | 0.2542 | Inherited |
| Histone lysine methyltransferases | 0.2542 | Inherited |
| SH3-domain | 0.2587 | Inherited |
| Dual specificity phosphatase-like | 0.2766 | Inherited |
| Acetylcholinesterase-like | 0.2837 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.3014 | Inherited |
| Bromodomain | 0.3296 | Inherited |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 0.3296 | Inherited |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0.3296 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.3316 | Inherited |
| Extended AAA-ATPase domain | 0.3348 | Inherited |
| FAD/NAD-linked reductases, N-terminal and central domains | 0.3586 | Inherited |
| Cytochrome P450 | 0.3679 | Inherited |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.3911 | Inherited |
| Meta-cation ATPase, catalytic domain P | 0.3911 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.449 | Inherited |
| Pumilio repeat | 0.4617 | Inherited |
| GABA-aminotransferase-like | 0.4617 | Inherited |
| FKBP immunophilin/proline isomerase | 0.4754 | Inherited |
| Cation efflux protein transmembrane domain-like | 0.5007 | Inherited |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.5027 | Inherited |
| PHD domain | 0.532 | Inherited |
| Pyridoxal-dependent decarboxylase | 0.5451 | Inherited |
| Myosin rod fragments | 0.5451 | Inherited |
| Glutathione S-transferase (GST), N-terminal domain | 0.5486 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.586 | Inherited |
| Myb/SANT domain | 0.5895 | Inherited |
| Calpain large subunit, middle domain (domain III) | 0.5895 | Inherited |
| Gastric lipase | 0.5895 | Inherited |
| I set domains | 0.591 | Inherited |
| Papain-like | 0.6162 | Inherited |
| Class I alpha-1;2-mannosidase, catalytic domain | 0.6396 | Inherited |
| UBC-related | 0.6678 | Inherited |
| Synaptotagmin-like (S variant) | 0.6883 | Inherited |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.693 | Inherited |
| Osmotin, thaumatin-like protein | 0.693 | Inherited |
| Lipovitellin-phosvitin complex, superhelical domain | 0.693 | Inherited |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0.7191 | Inherited |
| BTB/POZ domain | 0.7452 | Inherited |
| Frizzled cysteine-rich domain | 0.7512 | Inherited |
| Transforming growth factor (TGF)-beta | 0.7512 | Inherited |
| EF-hand modules in multidomain proteins | 0.7512 | Inherited |
| Bacterial lipase | 0.8119 | Inherited |
| Cdc48 N-terminal domain-like | 0.8119 | Inherited |
| H-NOX domain | 0.8119 | Inherited |
| MIT domain | 0.8119 | Inherited |
| Ubiquitin-related | 0.8269 | Inherited |
| Voltage-gated potassium channels | 0.848 | Inherited |
| FAD-linked reductases, N-terminal domain | 0.8574 | Inherited |
| PAZ domain | 0.8889 | Inherited |
| LIM domain | 0.8935 | Inherited |
| Fibronectin type III | 0.9172 | Inherited |
| Glutathione S-transferase (GST), C-terminal domain | 0.9362 | Inherited |
| Leucine zipper domain | 0.9363 | Inherited |
| DnaQ-like 3'-5' exonuclease | 0.942 | Inherited |
| Calmodulin-like | 0.9636 | Inherited |
| Nuclear receptor ligand-binding domain | 0.9835 | Inherited |
| NagD-like | 0.9855 | Inherited |
| Ribonuclease PH domain 2-like | 0.9855 | Inherited |
| Ribonuclease PH domain 1-like | 0.9855 | Inherited |
| RING finger domain, C3HC4 | 1 | Inherited |
| C-type lectin domain | 1 | Inherited |
| Glutathione peroxidase-like | 1 | Inherited |
| F-box domain | 1 | Inherited |
| Nuclear receptor | 1 | Inherited |
| B-box zinc-binding domain | 1 | Inherited |
| Cyclophilin (peptidylprolyl isomerase) | 1 | Inherited |
| N-acetyl transferase, NAT | 1 | Inherited |
| Rhodopsin-like | 1 | Inherited |
| Choline/Carnitine O-acyltransferase | 1 | Inherited |
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A presence/absence matrix is generated using protein domain
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this WP term (Not in SPWP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| beta-lactamase/transpeptidase-like | 0 | DIRECT |
| Acyl-CoA dehydrogenase NM domain-like | 0 | DIRECT |
| HSP20-like chaperones | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| Doublecortin (DC) | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| Type II DNA topoisomerase | 0 | DIRECT |
| Aldolase | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| SAND domain-like | 0 | DIRECT |
| PreATP-grasp domain | 0 | DIRECT |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| Intermediate filament protein, coiled coil region | 0 | DIRECT |
| Sec7 domain | 0 | DIRECT |
| Glycolipid transfer protein, GLTP | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| Cdc48 domain 2-like | 0 | DIRECT |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | DIRECT |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0 | DIRECT |
| S-adenosylmethionine synthetase | 0 | DIRECT |
| PK beta-barrel domain-like | 0 | DIRECT |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
| HMG-box | 0 | DIRECT |
| Molybdenum cofactor-binding domain | 0 | DIRECT |
| Oxysterol-binding protein-like | 0 | DIRECT |
| Mitochondrial carrier | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| Sec63 N-terminal domain-like | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| Nucleotidyltransferase | 0 | DIRECT |
| PIN domain-like | 0 | DIRECT |
| ClpP/crotonase | 0 | DIRECT |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | DIRECT |
| ThrRS/AlaRS common domain | 0 | DIRECT |
| Cystatin/monellin | 0 | DIRECT |
| Complement control module/SCR domain | 0 | DIRECT |
| SAICAR synthase-like | 0 | DIRECT |
| Pentein | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| Hypothetical protein c14orf129, hspc210 | 0 | DIRECT |
| Phoshotransferase/anion transport protein | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| t-snare proteins | 0 | DIRECT |
| CAD & PB1 domains | 0 | DIRECT |
| Zn-binding ribosomal proteins | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Tubulin nucleotide-binding domain-like | 0 | DIRECT |
| Creatinase/prolidase N-terminal domain | 0 | DIRECT |
| 2Fe-2S ferredoxin-like | 0 | DIRECT |
| DEATH domain | 0 | DIRECT |
| ENTH/VHS domain | 0 | DIRECT |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Carbon-nitrogen hydrolase | 0 | DIRECT |
| Thyroglobulin type-1 domain | 0 | DIRECT |
| Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| AN1-like Zinc finger | 0 | DIRECT |
| YbiA-like | 0 | DIRECT |
| PABC (PABP) domain | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| ArfGap/RecO-like zinc finger | 0 | DIRECT |
| LysM domain | 0 | DIRECT |
| Nucleoside diphosphate kinase, NDK | 0 | DIRECT |
| GINS helical bundle-like | 0 | DIRECT |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Calcium-dependent phosphotriesterase | 0 | DIRECT |
| eIF4e-like | 0 | DIRECT |
| Terpenoid synthases | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| WGR domain-like | 0 | DIRECT |
| HCP-like | 0 | DIRECT |
| Carbohydrate phosphatase | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | DIRECT |
| CO dehydrogenase ISP C-domain like | 0 | DIRECT |
| GroEL apical domain-like | 0 | DIRECT |
| Clc chloride channel | 0 | DIRECT |
| Cadherin-like | 0 | DIRECT |
| Ribosomal protein L10-like | 0 | DIRECT |
| CBD9-like | 0 | DIRECT |
| RBP11-like subunits of RNA polymerase | 0 | DIRECT |
| PurM C-terminal domain-like | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| PLC-like phosphodiesterases | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| Heme-dependent catalase-like | 0 | DIRECT |
| lambda repressor-like DNA-binding domains | 0 | DIRECT |
| Citrate synthase | 0 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
| TK C-terminal domain-like | 0 | DIRECT |
| Single hybrid motif | 0 | DIRECT |
| Insulin-like | 0 | DIRECT |
| Chaperone J-domain | 0 | DIRECT |
| Galactose oxidase, central domain | 0 | DIRECT |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
| Galactose mutarotase-like | 0 | DIRECT |
| Protease propeptides/inhibitors | 0 | DIRECT |
| Activating enzymes of the ubiquitin-like proteins | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| Band 7/SPFH domain | 0 | DIRECT |
| Carboxypeptidase regulatory domain-like | 0 | DIRECT |
| MgtE membrane domain-like | 0 | DIRECT |
| Actin-like ATPase domain | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Aquaporin-like | 0 | DIRECT |
| Tubby C-terminal domain-like | 0 | DIRECT |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | DIRECT |
| GAT-like domain | 0 | DIRECT |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
| CRAL/TRIO N-terminal domain | 0 | DIRECT |
| GHMP Kinase, C-terminal domain | 0 | DIRECT |
| Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
| Ribosomal protein S10 | 0 | DIRECT |
| Restriction endonuclease-like | 0 | DIRECT |
| Ribosomal protein L1 | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| L30e-like | 0 | DIRECT |
| Hedgehog/intein (Hint) domain | 0 | DIRECT |
| ARID-like | 0 | DIRECT |
| Putative DNA-binding domain | 0 | DIRECT |
| Translational machinery components | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| Integrin alpha N-terminal domain | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| MOSC N-terminal domain-like | 0 | DIRECT |
| Elafin-like | 0 | DIRECT |
| Outer arm dynein light chain 1 | 0 | DIRECT |
| PEP carboxykinase-like | 0 | DIRECT |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
| Heme-dependent peroxidases | 0 | DIRECT |
| cAMP-binding domain-like | 0 | DIRECT |
| Cytochrome c | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| Pepsin inhibitor-3 | 0 | DIRECT |
| PEBP-like | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| Spectrin repeat | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| DNA repair protein MutS, domain III | 0 | DIRECT |
| SMAD/FHA domain | 0 | DIRECT |
| Chitinase insertion domain | 0 | DIRECT |
| ISP domain | 0 | DIRECT |
| L-aspartase-like | 0 | DIRECT |
| BEACH domain | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| TGS-like | 0 | DIRECT |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
| Class II aaRS ABD-related | 0 | DIRECT |
| Second domain of FERM | 0 | DIRECT |
| GYF domain | 0 | DIRECT |
| Subtilisin-like | 0 | DIRECT |
| PYP-like sensor domain (PAS domain) | 0 | DIRECT |
| LDH C-terminal domain-like | 0 | DIRECT |
| JAB1/MPN domain | 0 | DIRECT |
| PurM N-terminal domain-like | 0 | DIRECT |
| Fibrinogen C-terminal domain-like | 0 | DIRECT |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0 | DIRECT |
| Ferritin-like | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| Ribosomal L27 protein-like | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| Invertebrate chitin-binding proteins | 0 | DIRECT |
| PHM/PNGase F | 0 | DIRECT |
| FtsH protease domain-like | 0 | DIRECT |
| Radical SAM enzymes | 0 | DIRECT |
| Hormone receptor domain | 0 | DIRECT |
| Skp1 dimerisation domain-like | 0 | DIRECT |
| Class I glutamine amidotransferase-like | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
| Thiolase-like | 0 | DIRECT |
| Ribokinase-like | 0 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
| Ribosomal proteins S24e, L23 and L15e | 0 | DIRECT |
| Small-conductance potassium channel | 0 | DIRECT |
| Polo-box domain | 0 | DIRECT |
| Nucleoporin domain | 0 | DIRECT |
| PAP/OAS1 substrate-binding domain | 0 | DIRECT |
| VPS9 domain | 0 | DIRECT |
| Chromo domain-like | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | DIRECT |
| GroES-like | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| Kringle-like | 0 | DIRECT |
| ADP-ribosylation | 0 | DIRECT |
| alpha-catenin/vinculin-like | 0 | DIRECT |
| GAS2 domain-like | 0 | DIRECT |
| dsRNA-binding domain-like | 0 | DIRECT |
| LEM domain | 0 | DIRECT |
| Surp module (SWAP domain) | 0 | DIRECT |
| SIS domain | 0 | DIRECT |
| Rudiment single hybrid motif | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| Alpha-L RNA-binding motif | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
| Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
| alpha/beta knot | 0 | DIRECT |
| Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
| Hect, E3 ligase catalytic domain | 0 | DIRECT |
| Periplasmic binding protein-like II | 0 | DIRECT |
| Troponin coil-coiled subunits | 0 | DIRECT |
| Families 57/38 glycoside transferase middle domain | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| PUA domain-like | 0 | DIRECT |
| Rap/Ran-GAP | 0 | DIRECT |
| Ran binding protein zinc finger-like | 0 | DIRECT |
| Profilin (actin-binding protein) | 0 | DIRECT |
| Carbonic anhydrase | 0 | DIRECT |
| Diaminopimelate epimerase-like | 0 | DIRECT |
| SCP-like | 0 | DIRECT |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
| R3H domain | 0 | DIRECT |
| Arginase/deacetylase | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
| Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
| Annexin | 0 | DIRECT |
| Tricorn protease domain 2 | 0 | DIRECT |
| GroEL equatorial domain-like | 0 | DIRECT |
| Tubulin C-terminal domain-like | 0 | DIRECT |
| MFPT repeat-like | 0 | DIRECT |
| Tim10-like | 0 | DIRECT |
| Cullin repeat-like | 0 | DIRECT |
| WWE domain | 0 | DIRECT |
| PGBD-like | 0 | DIRECT |
| Purine and uridine phosphorylases | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| YWTD domain | 0 | DIRECT |
| GroEL-intermediate domain like | 0 | DIRECT |
| P-loop containing nucleoside triphosphate hydrolases | 0.0000002118 | DIRECT |
| PH domain-like | 0.00007064 | DIRECT |
| Histone-fold | 0.0001602 | DIRECT |
| Protein kinase-like (PK-like) | 0.008081 | INHERITED FROM: transgene expression reduced || mechanosensation variant || egg laying response to food variant || metal response variant || drug induced gene expression variant || second messenger mediated signaling variant || octanol chemotaxis defective || alkaline pH chemotaxis variant || anoxia resistant || colchicine resistant || life span variant || positive chemotaxis variant || lipid synthesis increased || pathogen induced gene expression variant || kinase activity reduced || organism osmostic stress hypersensitive || protein phosphorylation variant || protein phosphorylation reduced || conflicting sensory integration variant || aldicarb response variant || protein subcellular localization variant || organism environmental stimulus response variant || chemical response variant || protein expression variant |
| PDZ domain-like | 0.01286 | INHERITED FROM: acetylcholinesterase inhibitor response variant || aldicarb response variant || protein expression variant || drug resistant |
| Nucleic acid-binding proteins | 0.02026 | INHERITED FROM: hydroxyurea response variant || nonsense mRNA accumulation || mRNA surveillance defective || hypoxia resistant || hydroxyurea hypersensitive || sick |
| Periplasmic binding protein-like I | 0.02074 | INHERITED FROM: lithium chemotaxis defective || aqueous positive chemotaxis variant || iodide chemotaxis defective || chemosensory response variant || aqueous chemosensory response variant || response to food variant || carbon dioxide avoidance variant || bromide chemotaxis variant || second messenger mediated signaling variant || memory retention defective || chemotaxis variant || iodide chemotaxis variant || diacetyl chemotaxis variant || benzaldehyde chemotaxis variant || magnesium chemotaxis defective || AWC odorant chemotaxis defective || alkaline pH chemotaxis variant || AWC odorant chemotaxis variant || positive chemotaxis variant || bromide chemotaxis defective || organism environmental stimulus response variant || chemical response variant |
| TPR-like | 0.02126 | INHERITED FROM: chemotaxis variant || dauer defective || light body touch resistant || associative learning variant || positive chemotaxis defective |
| "Winged helix" DNA-binding domain | 0.02257 | INHERITED FROM: spontaneous mutation rate increased || protein aggregation induced behavior variant || protein expression increased || germline transgene silencing variant || paraquat hypersensitive || growth rate variant || organism metabolism processing variant || chemical hypersensitive || life span variant || anesthetic response variant || protein protein interaction variant || protein aggregation variant || shortened life span |
| PapD-like | 0.03483 | INHERITED FROM: larval growth variant || developmental growth variant || slow growth || lipid metabolism variant || larval arrest || dauer lifespan variant || dauer metabolism variant || dauer lifespan extended || fat content variant |
| WD40 repeat-like | 0.0447 | INHERITED FROM: protein aggregation induced behavior variant || late larval arrest || early larval arrest || organism metabolism processing variant || antimicrobial gene expression variant || osmotic avoidance variant || protein protein interaction variant || protein aggregation variant |
| ARM repeat | 0.04566 | INHERITED FROM: organism hypersensitive ionizing radiation || organism metabolism processing variant || gene expression variant || RNAi response variant || sick || protein expression variant |
| SH2 domain | 0.05019 | INHERITED FROM: level of protein expression variant || aldicarb resistant || acetylcholinesterase inhibitor resistant || protein expression reduced || protein expression variant |
| Homeodomain-like | 0.06848 | INHERITED FROM: imipramine resistant || adrenergic receptor antagonist response variant || sexually dimorphic physiology variant || carbon dioxide avoidance variant || growth rate variant || organism metabolism processing variant || carbon dioxide response variant || egg laying imipramine resistant || inhibitor of serotonin uptake variant || level of transgene expression variant || ectopic expression transgene || protein degradation variant |
| Acetyl-CoA synthetase-like | 0.07106 | INHERITED FROM: lipid metabolism variant |
| Calponin-homology domain, CH-domain | 0.07106 | INHERITED FROM: protein degradation variant |
| Cyclin-like | 0.07868 | INHERITED FROM: protein phosphorylation variant || protein phosphorylation reduced |
| CCCH zinc finger | 0.08704 | INHERITED FROM: mRNA expression ectopic || transgene expression variant || organism metabolism processing variant || gene expression variant || ectopic expression transgene |
| EGF/Laminin | 0.0893 | INHERITED FROM: octanol chemotaxis variant || octanol chemotaxis defective || odorant negative chemotaxis defective || negative chemotaxis variant |
| Translation proteins | 0.1066 | INHERITED FROM: transgene expression variant || organism metabolism processing variant || protein phosphorylation increased || gene expression variant || protein protein interaction variant || protein phosphorylation variant || proteasome core activity variant || protein aggregation variant || mRNA levels increased || sick |
| Galactose-binding domain-like | 0.114 | INHERITED FROM: protein interaction variant || protein protein interaction variant || protein aggregation variant |
| Ankyrin repeat | 0.1179 | INHERITED FROM: octanol chemotaxis variant || chemosensory response variant || organism heat response variant || octanol chemotaxis defective || chemotaxis variant || odorant negative chemotaxis defective |
| HLH, helix-loop-helix DNA-binding domain | 0.1339 | INHERITED FROM: aqueous positive chemotaxis variant || gene expression level reduced || hypoxia response variant || organism metabolism processing variant || RNA expression variant || aqueous positive chemotaxis defective || lysine chemotaxis defective || ectopic expression transgene |
| ABC transporter transmembrane region | 0.1339 | INHERITED FROM: colchicine hypersensitive || metal response variant || cadmium response variant || RNAi response variant || organism environmental stimulus response variant |
| Nucleotide cyclase | 0.1339 | INHERITED FROM: lithium chemotaxis defective || iodide chemotaxis defective || chemosensory response variant || bromide chemotaxis variant || second messenger mediated signaling variant || cation positive chemotaxis defective || chemotaxis variant || iodide chemotaxis variant || diacetyl chemotaxis variant || magnesium chemotaxis defective || anion positive chemotaxis defective || AWC odorant chemotaxis defective || carbon dioxide response variant || alkaline pH chemotaxis variant || AWC odorant chemotaxis variant || positive chemotaxis variant || osmotic avoidance variant || cation positive chemotaxis variant || bromide chemotaxis defective || organism environmental stimulus response variant |
| RNI-like | 0.1415 | INHERITED FROM: resistant to protein aggregation induced paralysis |
| Calcium ATPase, transmembrane domain M | 0.1438 | INHERITED FROM: nicotine hypersensitive || lipid composition variant || organism environmental stimulus response variant |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1589 | INHERITED FROM: nicotine hypersensitive || lipid composition variant || organism environmental stimulus response variant |
| Regulator of G-protein signaling, RGS | 0.1589 | INHERITED FROM: mechanosensation variant || chemotaxis variant || negative chemotaxis variant |
| Calcium ATPase, transduction domain A | 0.1754 | INHERITED FROM: nicotine hypersensitive || organism environmental stimulus response variant |
| Class II aaRS and biotin synthetases | 0.1754 | INHERITED FROM: hypoxia response variant || transgene expression variant || organism metabolism processing variant || gene expression variant || oxygen response variant || hypoxia resistant || organism environmental stimulus response variant |
| SH3-domain | 0.1807 | INHERITED FROM: protein phosphorylation variant || aldicarb response variant || protein expression reduced || protein expression variant |
| E set domains | 0.1833 | INHERITED FROM: paraquat hypersensitive |
| Quinoprotein alcohol dehydrogenase-like | 0.1935 | INHERITED FROM: L2 arrest || hypoxia response variant || protein metabolism variant || mid larval arrest || fat content increased || mRNA levels increased || protein degradation variant |
| DBL homology domain (DH-domain) | 0.2136 | INHERITED FROM: bacterially unswollen || pathogen resistance increased || aldicarb response variant || organism pathogen response variant || organism environmental stimulus response variant || protein degradation variant |
| WW domain | 0.2136 | INHERITED FROM: aldicarb resistant || acetylcholinesterase inhibitor resistant || maintenance of gene silencing variant |
| Multidrug efflux transporter AcrB transmembrane domain | 0.2146 | INHERITED FROM: odorant chemosensory response variant || chemotaxis variant || odorant positive chemotaxis defective || positive chemotaxis defective || embryo osmotic integrity defective early emb || egg integrity defective early emb |
| Cytochrome P450 | 0.2576 | INHERITED FROM: metal response variant || cadmium response variant |
| (Trans)glycosidases | 0.2576 | INHERITED FROM: pathogen susceptibility increased || pathogen load variant |
| Multidrug resistance efflux transporter EmrE | 0.2595 | INHERITED FROM: bacterially unswollen || pathogen resistance increased |
| BRCT domain | 0.2683 | INHERITED FROM: organism ionizing radiation response variant |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.2856 | INHERITED FROM: lipid metabolism variant || fat content variant |
| Bromodomain | 0.2856 | INHERITED FROM: anesthetic resistant || acute functional tolerance to alcohol defective || organism UV hypersensitive || organism UV response variant || anesthetic response variant || drug adaptation variant || organism stress response variant || ethanol resistant || sick |
| Nucleotidylyl transferase | 0.3097 | INHERITED FROM: transgene expression increased || hypoxia response variant || organism metabolism processing variant || oxygen response variant || hypoxia resistant || organism environmental stimulus response variant || paraquat resistant |
| POZ domain | 0.3117 | INHERITED FROM: protein aggregation induced behavior variant || early larval arrest || resistant to protein aggregation induced paralysis || chemical hypersensitive || L1 arrest |
| SNARE-like | 0.3139 | INHERITED FROM: transgene subcellular localization variant || acetylcholinesterase inhibitor response variant || aldicarb resistant || transgene expression variant || organism metabolism processing variant || acetylcholinesterase inhibitor resistant || protein metabolism variant || gene expression variant || aldicarb response variant || pattern of transgene expression variant || sick |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.3192 | INHERITED FROM: aging variant || drug induced gene expression variant || growth rate variant || antimicrobial gene expression variant || metabolic pathway variant || RNAi response variant || protein subcellular localization variant || nose touch variant || organism environmental stimulus response variant || chemical response variant || protein expression variant || drug resistant |
| Cysteine proteinases | 0.3205 | INHERITED FROM: osmotic integrity variant || hypoosmotic shock hypersensitive || paraquat hypersensitive || organism metabolism processing variant || protein interaction variant || protein protein interaction variant || pattern of transgene expression variant |
| RNA-binding domain, RBD | 0.3232 | INHERITED FROM: no induction of antimicrobial peptide expression after infection || starvation induced apoptosis variant || mRNA export variant || organism metabolism processing variant || RNA expression variant || antimicrobial gene expression variant || maintenance of gene silencing variant || innate immune response variant || alternative splicing variant || sick || RNA processing variant |
| Ribosomal protein S5 domain 2-like | 0.3292 | INHERITED FROM: early larval arrest || transgene expression variant |
| Lipocalins | 0.333 | INHERITED FROM: paraquat hypersensitive || lipid metabolism variant || fat content increased || fat content variant |
| SAM/Pointed domain | 0.333 | INHERITED FROM: aldicarb response variant |
| Cation efflux protein transmembrane domain-like | 0.3801 | INHERITED FROM: metal response variant || manganese response variant || cadmium hypersensitive || manganese toxicity resistant |
| Translation proteins SH3-like domain | 0.3801 | INHERITED FROM: early larval arrest || transgene expression variant || organism metabolism processing variant || gene expression variant || protein protein interaction variant || protein aggregation variant |
| Acid proteases | 0.4098 | INHERITED FROM: transgene subcellular localization variant || osmotic integrity variant || hypoosmotic shock hypersensitive || transgene expression variant || organism metabolism processing variant || protein interaction variant || gene expression variant || protein protein interaction variant || pattern of transgene expression variant || protein aggregation variant |
| Tropomyosin | 0.4171 | INHERITED FROM: drug resistant |
| FKBP-like | 0.4293 | INHERITED FROM: transgene subcellular localization variant || protein interaction variant || protein protein interaction variant || pattern of transgene expression variant || protein aggregation variant |
| Nicotinic receptor ligand binding domain-like | 0.4302 | INHERITED FROM: mechanosensation variant || hypoosmotic shock hypersensitive || aqueous chemosensory response variant || antihelmintic response variant || nicotine resistant || cholinergic agonist resistant || drug response variant || selenium response variant || DMPP response variant || sodium chloride chemotaxis variant || organism environmental stimulus response variant || chemical response variant |
| Cysteine-rich domain | 0.4367 | INHERITED FROM: odorant chemosensory response variant || drug induced gene expression variant || odorant positive chemotaxis variant || bacterially unswollen || organism metabolism processing variant || antimicrobial gene expression variant || positive chemotaxis variant || aldicarb response variant || organism pathogen response variant || protein subcellular localization variant |
| Ubiquitin-like | 0.4407 | INHERITED FROM: heteroplasmy || organism metabolism processing variant || protein interaction variant || protein protein interaction variant || protein aggregation variant |
| FYVE/PHD zinc finger | 0.4427 | INHERITED FROM: organism UV hypersensitive || organism UV response variant || protein modification variant || protein methylation variant || ectopic expression transgene |
| HAD-like | 0.462 | INHERITED FROM: nicotine hypersensitive |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.4665 | INHERITED FROM: mechanosensation variant || hypoosmotic shock hypersensitive || aqueous chemosensory response variant || antihelmintic response variant || nicotine resistant || cholinergic agonist resistant || drug response variant || selenium response variant || positive chemotaxis variant || DMPP response variant || sodium chloride chemotaxis variant || organism environmental stimulus response variant || chemical response variant || protein degradation variant |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.4665 | INHERITED FROM: organism osmotic stress response variant |
| PRTase-like | 0.5016 | INHERITED FROM: Fluorouracil resistant || drug resistant |
| Myosin rod fragments | 0.5016 | INHERITED FROM: drug resistant |
| DHS-like NAD/FAD-binding domain | 0.5016 | INHERITED FROM: protein acetylation variant || life span variant || protein modification variant |
| Riboflavin synthase domain-like | 0.5499 | INHERITED FROM: pattern protein expression variant |
| Calpain large subunit, middle domain (domain III) | 0.5499 | INHERITED FROM: protein metabolism variant || metabolic pathway variant || protein degradation variant |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.5499 | INHERITED FROM: pattern protein expression variant |
| FAD-linked reductases, C-terminal domain | 0.562 | INHERITED FROM: life span variant |
| Sm-like ribonucleoproteins | 0.562 | INHERITED FROM: organism heat response variant || transgene expression variant || gene expression variant || life span variant || unfolded protein response variant || pattern of transgene expression variant || protein subcellular localization variant || sick |
| Cystine-knot cytokines | 0.562 | INHERITED FROM: nicotine response variant || levamisole response variant |
| Voltage-gated potassium channels | 0.5956 | INHERITED FROM: adrenergic receptor antagonist response variant || mechanosensation variant || growth rate variant || serotonin response variant || protein metabolism variant || metabolic pathway variant || positive chemotaxis defective || protein degradation variant |
| Seven-hairpin glycosidases | 0.5998 | INHERITED FROM: extended life span || protein protein interaction variant || protein aggregation variant |
| FAD/NAD(P)-binding domain | 0.6015 | INHERITED FROM: ATP levels variant || pesticide response variant || ATP levels reduced || life span variant |
| SET domain | 0.6081 | INHERITED FROM: spontaneous mutation rate increased || histone methylation variant || somatic transgene silencing variant || ectopic expression antibody || life span variant || dosage compensation variant || maintenance of gene silencing variant || protein modification variant || protein methylation variant || RNAi response variant || shortened life span || protein expression variant |
| Growth factor receptor domain | 0.6168 | INHERITED FROM: protein degradation variant |
| UBC-like | 0.6322 | INHERITED FROM: transgene subcellular localization variant || late larval arrest || organism metabolism processing variant || protein interaction variant || gene expression variant || protein protein interaction variant || pattern of transgene expression variant || protein aggregation variant || sick |
| Clavaminate synthase-like | 0.6458 | INHERITED FROM: life span variant || organism temperature response variant |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.6566 | INHERITED FROM: transgene subcellular localization variant || pathogen susceptibility increased || life span variant || organism pathogen response variant || organism environmental stimulus response variant |
| KA1-like | 0.6566 | INHERITED FROM: RNA expression variant |
| Nucleotide-binding domain | 0.6566 | INHERITED FROM: extended life span || life span variant |
| Osmotin, thaumatin-like protein | 0.6566 | INHERITED FROM: transgene expression reduced || metal response variant || cadmium response variant || cadmium hypersensitive |
| Lipovitellin-phosvitin complex, superhelical domain | 0.6566 | INHERITED FROM: transgene subcellular localization variant || pathogen susceptibility increased || life span variant || organism pathogen response variant || organism environmental stimulus response variant |
| MFS general substrate transporter | 0.665 | INHERITED FROM: organism high sodium chloride hypersensitive |
| GTPase activation domain, GAP | 0.7077 | INHERITED FROM: protein expression variant |
| S15/NS1 RNA-binding domain | 0.719 | INHERITED FROM: transgene expression increased |
| 4Fe-4S ferredoxins | 0.719 | INHERITED FROM: extended life span |
| Frizzled cysteine-rich domain | 0.719 | INHERITED FROM: transgene expression reduced || antibody staining variant |
| GST C-terminal domain-like | 0.7454 | INHERITED FROM: cadmium response variant || enzyme activity reduced || organism electrophilic stress hypersensitive || enzyme activity variant || organism stress response variant || organism heat hypersensitive || cadmium hypersensitive || organism environmental stimulus response variant |
| PAZ domain | 0.7808 | INHERITED FROM: somatic transgene silencing variant || RNA expression variant || 21U RNA expression variant || maintenance of gene silencing variant || RNAi enhanced || RNAi response variant || siRNA expression variant || mRNA levels increased |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.7843 | INHERITED FROM: transgene expression reduced || gene expression level reduced || gene expression level high || fat content increased || level of transgene expression variant || SDS sensitive dauer || dauer resistance to harsh conditions variant |
| Ribonuclease H-like | 0.7852 | INHERITED FROM: somatic transgene silencing variant || RNA expression variant || 21U RNA expression variant || maintenance of gene silencing variant || RNAi enhanced || RNAi response variant || siRNA expression variant |
| ADC-like | 0.7861 | INHERITED FROM: protein metabolism variant || protein interaction variant || metabolic pathway variant || protein protein interaction variant || protein aggregation variant || level of transgene expression variant |
| MIT domain | 0.7861 | INHERITED FROM: protein interaction variant || protein protein interaction variant || protein aggregation variant |
| alpha/beta-Hydrolases | 0.796 | INHERITED FROM: acetylcholinesterase activity variant || acetylcholinesterase reduced |
| Fibronectin type III | 0.8448 | INHERITED FROM: growth rate variant || protein degradation variant |
| Leucine zipper domain | 0.886 | INHERITED FROM: transgene expression reduced || pathogen susceptibility increased || mRNA expression variant || pore forming toxin response variant || level of transgene expression variant || mRNA levels reduced |
| UBA-like | 0.8974 | INHERITED FROM: protein protein interaction variant || protein aggregation variant |
| EF-hand | 0.9004 | INHERITED FROM: protein interaction variant || protein aggregation variant |
| DNA/RNA polymerases | 0.9538 | INHERITED FROM: DNA repair variant || DNA metabolism variant |
| p53-like transcription factors | 0.963 | INHERITED FROM: gene expression level reduced || level of transgene expression variant || ectopic expression transgene |
| Ribonuclease PH domain 2-like | 0.9648 | INHERITED FROM: early larval arrest |
| beta-beta-alpha zinc fingers | 0.9874 | INHERITED FROM: imipramine resistant || egg laying serotonin resistant || organism metabolism processing variant || egg laying imipramine resistant || inhibitor of serotonin uptake variant |
| Immunoglobulin | 0.9902 | INHERITED FROM: growth rate variant || aldicarb response variant || protein degradation variant |
| Thioredoxin-like | 0.9989 | INHERITED FROM: paraquat response variant || pesticide response variant || enzyme activity reduced || organism electrophilic stress hypersensitive || enzyme activity variant || organism stress response variant || organism heat hypersensitive || cadmium hypersensitive || organism environmental stimulus response variant |
| Saposin | 1 | INHERITED FROM: transgene expression reduced || transgene expression variant || increased pathogen survival || pathogen load variant || level of transgene expression variant |
| CoA-dependent acyltransferases | 1 | INHERITED FROM: lipid metabolism variant |
| Ligand-binding domain in the NO signalling and Golgi transport | 1 | INHERITED FROM: carbon dioxide avoidance variant || carbon dioxide response variant |
| Nuclear receptor ligand-binding domain | 1 | INHERITED FROM: transgene expression reduced || gene expression level reduced || gene expression level high || lipid metabolism variant || fat content increased || level of transgene expression variant || SDS sensitive dauer || dauer resistance to harsh conditions variant |
| Bet v1-like | 1 | INHERITED FROM: growth rate variant |
| Eukaryotic type KH-domain (KH-domain type I) | 1 | INHERITED FROM: RNA expression variant |
| RING/U-box | 1 | INHERITED FROM: transgene subcellular localization variant || transgene expression variant || organism metabolism processing variant || protein interaction variant || gene expression variant || protein protein interaction variant || pattern of transgene expression variant || protein aggregation variant |
| F-box domain | 1 | INHERITED FROM: resistant to protein aggregation induced paralysis |
| B-box zinc-binding domain | 1 | INHERITED FROM: transgene subcellular localization variant || transgene expression variant || organism metabolism processing variant || protein interaction variant || gene expression variant || protein protein interaction variant || protein aggregation variant |
| Cyclophilin-like | 1 | INHERITED FROM: transgene subcellular localization variant || transgene expression variant || protein interaction variant || gene expression variant || protein protein interaction variant || pattern of transgene expression variant || protein aggregation variant |
| Family A G protein-coupled receptor-like | 1 | INHERITED FROM: male tail curling serotonin variant || serotonin induced pumping variant || locomotion rate serotonin variant || serotonin induced fat reduction variant |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| beta-lactamase/transpeptidase-like | 0 | Direct |
| Acyl-CoA dehydrogenase NM domain-like | 0 | Direct |
| HSP20-like chaperones | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| Doublecortin (DC) | 0 | Direct |
| MIR domain | 0 | Direct |
| Type II DNA topoisomerase | 0 | Direct |
| Aldolase | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| SAND domain-like | 0 | Direct |
| PreATP-grasp domain | 0 | Direct |
| Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
| Intermediate filament protein, coiled coil region | 0 | Direct |
| Sec7 domain | 0 | Direct |
| Glycolipid transfer protein, GLTP | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| Cdc48 domain 2-like | 0 | Direct |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | Direct |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0 | Direct |
| S-adenosylmethionine synthetase | 0 | Direct |
| PK beta-barrel domain-like | 0 | Direct |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
| HMG-box | 0 | Direct |
| Molybdenum cofactor-binding domain | 0 | Direct |
| Oxysterol-binding protein-like | 0 | Direct |
| Mitochondrial carrier | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| Sec63 N-terminal domain-like | 0 | Direct |
| ALDH-like | 0 | Direct |
| Nucleotidyltransferase | 0 | Direct |
| PIN domain-like | 0 | Direct |
| ClpP/crotonase | 0 | Direct |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | Direct |
| ThrRS/AlaRS common domain | 0 | Direct |
| Cystatin/monellin | 0 | Direct |
| Complement control module/SCR domain | 0 | Direct |
| SAICAR synthase-like | 0 | Direct |
| Pentein | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| Hypothetical protein c14orf129, hspc210 | 0 | Direct |
| Phoshotransferase/anion transport protein | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| t-snare proteins | 0 | Direct |
| CAD & PB1 domains | 0 | Direct |
| Zn-binding ribosomal proteins | 0 | Direct |
| Integrin domains | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Tubulin nucleotide-binding domain-like | 0 | Direct |
| Creatinase/prolidase N-terminal domain | 0 | Direct |
| 2Fe-2S ferredoxin-like | 0 | Direct |
| DEATH domain | 0 | Direct |
| ENTH/VHS domain | 0 | Direct |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | Direct |
| Carbon-nitrogen hydrolase | 0 | Direct |
| Thyroglobulin type-1 domain | 0 | Direct |
| Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| AN1-like Zinc finger | 0 | Direct |
| YbiA-like | 0 | Direct |
| PABC (PABP) domain | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| ArfGap/RecO-like zinc finger | 0 | Direct |
| LysM domain | 0 | Direct |
| Nucleoside diphosphate kinase, NDK | 0 | Direct |
| GINS helical bundle-like | 0 | Direct |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Calcium-dependent phosphotriesterase | 0 | Direct |
| eIF4e-like | 0 | Direct |
| Terpenoid synthases | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| WGR domain-like | 0 | Direct |
| HCP-like | 0 | Direct |
| Carbohydrate phosphatase | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| SPOC domain-like | 0 | Direct |
| PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | Direct |
| CO dehydrogenase ISP C-domain like | 0 | Direct |
| GroEL apical domain-like | 0 | Direct |
| Clc chloride channel | 0 | Direct |
| Cadherin-like | 0 | Direct |
| Ribosomal protein L10-like | 0 | Direct |
| CBD9-like | 0 | Direct |
| RBP11-like subunits of RNA polymerase | 0 | Direct |
| PurM C-terminal domain-like | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| PLC-like phosphodiesterases | 0 | Direct |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| Heme-dependent catalase-like | 0 | Direct |
| lambda repressor-like DNA-binding domains | 0 | Direct |
| Citrate synthase | 0 | Direct |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
| TK C-terminal domain-like | 0 | Direct |
| Single hybrid motif | 0 | Direct |
| Insulin-like | 0 | Direct |
| Chaperone J-domain | 0 | Direct |
| Galactose oxidase, central domain | 0 | Direct |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
| Galactose mutarotase-like | 0 | Direct |
| Protease propeptides/inhibitors | 0 | Direct |
| Activating enzymes of the ubiquitin-like proteins | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| Band 7/SPFH domain | 0 | Direct |
| Carboxypeptidase regulatory domain-like | 0 | Direct |
| MgtE membrane domain-like | 0 | Direct |
| Actin-like ATPase domain | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Aquaporin-like | 0 | Direct |
| Tubby C-terminal domain-like | 0 | Direct |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | Direct |
| GAT-like domain | 0 | Direct |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
| CRAL/TRIO N-terminal domain | 0 | Direct |
| GHMP Kinase, C-terminal domain | 0 | Direct |
| Glutathione synthetase ATP-binding domain-like | 0 | Direct |
| Ribosomal protein S10 | 0 | Direct |
| Restriction endonuclease-like | 0 | Direct |
| Ribosomal protein L1 | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| L30e-like | 0 | Direct |
| Hedgehog/intein (Hint) domain | 0 | Direct |
| ARID-like | 0 | Direct |
| Putative DNA-binding domain | 0 | Direct |
| Translational machinery components | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| Integrin alpha N-terminal domain | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
| MOSC N-terminal domain-like | 0 | Direct |
| Elafin-like | 0 | Direct |
| Outer arm dynein light chain 1 | 0 | Direct |
| PEP carboxykinase-like | 0 | Direct |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
| Heme-dependent peroxidases | 0 | Direct |
| cAMP-binding domain-like | 0 | Direct |
| Cytochrome c | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| Pepsin inhibitor-3 | 0 | Direct |
| PEBP-like | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| Spectrin repeat | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| DNA repair protein MutS, domain III | 0 | Direct |
| SMAD/FHA domain | 0 | Direct |
| Chitinase insertion domain | 0 | Direct |
| ISP domain | 0 | Direct |
| L-aspartase-like | 0 | Direct |
| BEACH domain | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| TGS-like | 0 | Direct |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
| Class II aaRS ABD-related | 0 | Direct |
| Second domain of FERM | 0 | Direct |
| GYF domain | 0 | Direct |
| Subtilisin-like | 0 | Direct |
| PYP-like sensor domain (PAS domain) | 0 | Direct |
| LDH C-terminal domain-like | 0 | Direct |
| JAB1/MPN domain | 0 | Direct |
| PurM N-terminal domain-like | 0 | Direct |
| Fibrinogen C-terminal domain-like | 0 | Direct |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| Transducin (alpha subunit), insertion domain | 0 | Direct |
| Ferritin-like | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| Ribosomal L27 protein-like | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| Invertebrate chitin-binding proteins | 0 | Direct |
| PHM/PNGase F | 0 | Direct |
| FtsH protease domain-like | 0 | Direct |
| Radical SAM enzymes | 0 | Direct |
| Hormone receptor domain | 0 | Direct |
| Skp1 dimerisation domain-like | 0 | Direct |
| Class I glutamine amidotransferase-like | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| HSP40/DnaJ peptide-binding domain | 0 | Direct |
| Thiolase-like | 0 | Direct |
| Ribokinase-like | 0 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
| Ribosomal proteins S24e, L23 and L15e | 0 | Direct |
| Small-conductance potassium channel | 0 | Direct |
| Polo-box domain | 0 | Direct |
| Nucleoporin domain | 0 | Direct |
| PAP/OAS1 substrate-binding domain | 0 | Direct |
| VPS9 domain | 0 | Direct |
| Chromo domain-like | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | Direct |
| GroES-like | 0 | Direct |
| Nop domain | 0 | Direct |
| Kringle-like | 0 | Direct |
| ADP-ribosylation | 0 | Direct |
| alpha-catenin/vinculin-like | 0 | Direct |
| GAS2 domain-like | 0 | Direct |
| dsRNA-binding domain-like | 0 | Direct |
| LEM domain | 0 | Direct |
| Surp module (SWAP domain) | 0 | Direct |
| SIS domain | 0 | Direct |
| Rudiment single hybrid motif | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| Alpha-L RNA-binding motif | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
| Cation efflux protein cytoplasmic domain-like | 0 | Direct |
| alpha/beta knot | 0 | Direct |
| Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
| Hect, E3 ligase catalytic domain | 0 | Direct |
| Periplasmic binding protein-like II | 0 | Direct |
| Troponin coil-coiled subunits | 0 | Direct |
| Families 57/38 glycoside transferase middle domain | 0 | Direct |
| Proton glutamate symport protein | 0 | Direct |
| PUA domain-like | 0 | Direct |
| Rap/Ran-GAP | 0 | Direct |
| Ran binding protein zinc finger-like | 0 | Direct |
| Profilin (actin-binding protein) | 0 | Direct |
| Carbonic anhydrase | 0 | Direct |
| Diaminopimelate epimerase-like | 0 | Direct |
| SCP-like | 0 | Direct |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | Direct |
| FF domain | 0 | Direct |
| Bacterial exopeptidase dimerisation domain | 0 | Direct |
| R3H domain | 0 | Direct |
| Arginase/deacetylase | 0 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| Blood coagulation inhibitor (disintegrin) | 0 | Direct |
| Composite domain of metallo-dependent hydrolases | 0 | Direct |
| Annexin | 0 | Direct |
| Tricorn protease domain 2 | 0 | Direct |
| GroEL equatorial domain-like | 0 | Direct |
| Tubulin C-terminal domain-like | 0 | Direct |
| MFPT repeat-like | 0 | Direct |
| Tim10-like | 0 | Direct |
| Cullin repeat-like | 0 | Direct |
| WWE domain | 0 | Direct |
| PGBD-like | 0 | Direct |
| Purine and uridine phosphorylases | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| YWTD domain | 0 | Direct |
| GroEL-intermediate domain like | 0 | Direct |
| P-loop containing nucleoside triphosphate hydrolases | 0.0000002118 | Direct |
| PH domain-like | 0.00007064 | Direct |
| Histone-fold | 0.0001602 | Direct |
| Protein kinase-like (PK-like) | 0.008081 | Inherited |
| PDZ domain-like | 0.01286 | Inherited |
| Nucleic acid-binding proteins | 0.02026 | Inherited |
| Periplasmic binding protein-like I | 0.02074 | Inherited |
| TPR-like | 0.02126 | Inherited |
| "Winged helix" DNA-binding domain | 0.02257 | Inherited |
| PapD-like | 0.03483 | Inherited |
| WD40 repeat-like | 0.0447 | Inherited |
| ARM repeat | 0.04566 | Inherited |
| SH2 domain | 0.05019 | Inherited |
| Homeodomain-like | 0.06848 | Inherited |
| Acetyl-CoA synthetase-like | 0.07106 | Inherited |
| Calponin-homology domain, CH-domain | 0.07106 | Inherited |
| Cyclin-like | 0.07868 | Inherited |
| CCCH zinc finger | 0.08704 | Inherited |
| EGF/Laminin | 0.0893 | Inherited |
| Translation proteins | 0.1066 | Inherited |
| Galactose-binding domain-like | 0.114 | Inherited |
| Ankyrin repeat | 0.1179 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.1339 | Inherited |
| ABC transporter transmembrane region | 0.1339 | Inherited |
| Nucleotide cyclase | 0.1339 | Inherited |
| RNI-like | 0.1415 | Inherited |
| Calcium ATPase, transmembrane domain M | 0.1438 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1589 | Inherited |
| Regulator of G-protein signaling, RGS | 0.1589 | Inherited |
| Calcium ATPase, transduction domain A | 0.1754 | Inherited |
| Class II aaRS and biotin synthetases | 0.1754 | Inherited |
| SH3-domain | 0.1807 | Inherited |
| E set domains | 0.1833 | Inherited |
| Quinoprotein alcohol dehydrogenase-like | 0.1935 | Inherited |
| DBL homology domain (DH-domain) | 0.2136 | Inherited |
| WW domain | 0.2136 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.2146 | Inherited |
| Cytochrome P450 | 0.2576 | Inherited |
| (Trans)glycosidases | 0.2576 | Inherited |
| Multidrug resistance efflux transporter EmrE | 0.2595 | Inherited |
| BRCT domain | 0.2683 | Inherited |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.2856 | Inherited |
| Bromodomain | 0.2856 | Inherited |
| Nucleotidylyl transferase | 0.3097 | Inherited |
| POZ domain | 0.3117 | Inherited |
| SNARE-like | 0.3139 | Inherited |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.3192 | Inherited |
| Cysteine proteinases | 0.3205 | Inherited |
| RNA-binding domain, RBD | 0.3232 | Inherited |
| Ribosomal protein S5 domain 2-like | 0.3292 | Inherited |
| Lipocalins | 0.333 | Inherited |
| SAM/Pointed domain | 0.333 | Inherited |
| Cation efflux protein transmembrane domain-like | 0.3801 | Inherited |
| Translation proteins SH3-like domain | 0.3801 | Inherited |
| Acid proteases | 0.4098 | Inherited |
| Tropomyosin | 0.4171 | Inherited |
| FKBP-like | 0.4293 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.4302 | Inherited |
| Cysteine-rich domain | 0.4367 | Inherited |
| Ubiquitin-like | 0.4407 | Inherited |
| FYVE/PHD zinc finger | 0.4427 | Inherited |
| HAD-like | 0.462 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.4665 | Inherited |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.4665 | Inherited |
| PRTase-like | 0.5016 | Inherited |
| Myosin rod fragments | 0.5016 | Inherited |
| DHS-like NAD/FAD-binding domain | 0.5016 | Inherited |
| Riboflavin synthase domain-like | 0.5499 | Inherited |
| Calpain large subunit, middle domain (domain III) | 0.5499 | Inherited |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.5499 | Inherited |
| FAD-linked reductases, C-terminal domain | 0.562 | Inherited |
| Sm-like ribonucleoproteins | 0.562 | Inherited |
| Cystine-knot cytokines | 0.562 | Inherited |
| Voltage-gated potassium channels | 0.5956 | Inherited |
| Seven-hairpin glycosidases | 0.5998 | Inherited |
| FAD/NAD(P)-binding domain | 0.6015 | Inherited |
| SET domain | 0.6081 | Inherited |
| Growth factor receptor domain | 0.6168 | Inherited |
| UBC-like | 0.6322 | Inherited |
| Clavaminate synthase-like | 0.6458 | Inherited |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.6566 | Inherited |
| KA1-like | 0.6566 | Inherited |
| Nucleotide-binding domain | 0.6566 | Inherited |
| Osmotin, thaumatin-like protein | 0.6566 | Inherited |
| Lipovitellin-phosvitin complex, superhelical domain | 0.6566 | Inherited |
| MFS general substrate transporter | 0.665 | Inherited |
| GTPase activation domain, GAP | 0.7077 | Inherited |
| S15/NS1 RNA-binding domain | 0.719 | Inherited |
| 4Fe-4S ferredoxins | 0.719 | Inherited |
| Frizzled cysteine-rich domain | 0.719 | Inherited |
| GST C-terminal domain-like | 0.7454 | Inherited |
| PAZ domain | 0.7808 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.7843 | Inherited |
| Ribonuclease H-like | 0.7852 | Inherited |
| ADC-like | 0.7861 | Inherited |
| MIT domain | 0.7861 | Inherited |
| alpha/beta-Hydrolases | 0.796 | Inherited |
| Fibronectin type III | 0.8448 | Inherited |
| Leucine zipper domain | 0.886 | Inherited |
| UBA-like | 0.8974 | Inherited |
| EF-hand | 0.9004 | Inherited |
| DNA/RNA polymerases | 0.9538 | Inherited |
| p53-like transcription factors | 0.963 | Inherited |
| Ribonuclease PH domain 2-like | 0.9648 | Inherited |
| beta-beta-alpha zinc fingers | 0.9874 | Inherited |
| Immunoglobulin | 0.9902 | Inherited |
| Thioredoxin-like | 0.9989 | Inherited |
| Saposin | 1 | Inherited |
| CoA-dependent acyltransferases | 1 | Inherited |
| Ligand-binding domain in the NO signalling and Golgi transport | 1 | Inherited |
| Nuclear receptor ligand-binding domain | 1 | Inherited |
| Bet v1-like | 1 | Inherited |
| Eukaryotic type KH-domain (KH-domain type I) | 1 | Inherited |
| RING/U-box | 1 | Inherited |
| F-box domain | 1 | Inherited |
| B-box zinc-binding domain | 1 | Inherited |
| Cyclophilin-like | 1 | Inherited |
| Family A G protein-coupled receptor-like | 1 | Inherited |
(show details)
Supra-domains annotated to this WP term (Not in SPWP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0 | DIRECT |
103473,103473
103473 - MFS general substrate transporter
103473 - MFS general substrate transporter | 0 | DIRECT |
57889,50729
57889 - Cysteine-rich domain
50729 - PH domain-like | 0 | DIRECT |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0 | DIRECT |
50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
46785,46785
46785 - "Winged helix" DNA-binding domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
53738,55957
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
52283,51735
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | DIRECT |
51445,54556
51445 - (Trans)glycosidases
54556 - Chitinase insertion domain | 0 | DIRECT |
50044,52540
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | DIRECT |
55920,46785
55920 - Creatinase/aminopeptidase
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
56112,48371
56112 - Protein kinase-like (PK-like)
48371 - ARM repeat | 0 | DIRECT |
56601,48403
56601 - beta-lactamase/transpeptidase-like
48403 - Ankyrin repeat | 0 | DIRECT |
81324,81327
81324 - Voltage-gated potassium channels
81327 - Small-conductance potassium channel | 0 | DIRECT |
50978,50998
50978 - WD40 repeat-like
50998 - Quinoprotein alcohol dehydrogenase-like | 0 | DIRECT |
51971,54373
51971 - Nucleotide-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0 | DIRECT |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
54897,53187
54897 - Protease propeptides/inhibitors
53187 - Zn-dependent exopeptidases | 0 | DIRECT |
50044,50044
50044 - SH3-domain
50044 - SH3-domain | 0 | DIRECT |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0 | DIRECT |
161111,160240
161111 - Cation efflux protein transmembrane domain-like
160240 - Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | DIRECT |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | DIRECT |
64356,49447
64356 - SNARE-like
49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
54292,47741
54292 - 2Fe-2S ferredoxin-like
47741 - CO dehydrogenase ISP C-domain like | 0 | DIRECT |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0 | DIRECT |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0 | DIRECT |
81383,52047
81383 - F-box domain
52047 - RNI-like | 0 | DIRECT |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
47587,56399
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | DIRECT |
56672,100879
56672 - DNA/RNA polymerases
100879 - Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
57756,50630
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases | 0 | DIRECT |
161093,161093
161093 - MgtE membrane domain-like
161093 - MgtE membrane domain-like | 0 | DIRECT |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
51735,55347
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | DIRECT |
54211,55060
54211 - Ribosomal protein S5 domain 2-like
55060 - GHMP Kinase, C-terminal domain | 0 | DIRECT |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | DIRECT |
57414,57414
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like | 0 | DIRECT |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | DIRECT |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
54665,56003
54665 - CO dehydrogenase molybdoprotein N-domain-like
56003 - Molybdenum cofactor-binding domain | 0 | DIRECT |
81324,53850
81324 - Voltage-gated potassium channels
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
88713,88688
88713 - Glycoside hydrolase/deacetylase
88688 - Families 57/38 glycoside transferase middle domain | 0 | DIRECT |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0 | DIRECT |
51445,51445
51445 - (Trans)glycosidases
51445 - (Trans)glycosidases | 0 | DIRECT |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
52113,52113
52113 - BRCT domain
52113 - BRCT domain | 0 | DIRECT |
53901,53901
53901 - Thiolase-like
53901 - Thiolase-like | 0 | DIRECT |
55394,55394
55394 - Bactericidal permeability-increasing protein, BPI
55394 - Bactericidal permeability-increasing protein, BPI | 0 | DIRECT |
47473,103506
47473 - EF-hand
103506 - Mitochondrial carrier | 0 | DIRECT |
46938,52087
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain | 0 | DIRECT |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | DIRECT |
82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | DIRECT |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | DIRECT |
49742,49742
49742 - PHM/PNGase F
49742 - PHM/PNGase F | 0 | DIRECT |
53187,55031
53187 - Zn-dependent exopeptidases
55031 - Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
47203,47203
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
144232,82199
144232 - HIT/MYND zinc finger-like
82199 - SET domain | 0 | DIRECT |
57850,117839
57850 - RING/U-box
117839 - WWE domain | 0 | DIRECT |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | DIRECT |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
57938,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
51735,56327
51735 - NAD(P)-binding Rossmann-fold domains
56327 - LDH C-terminal domain-like | 0 | DIRECT |
54236,54236
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0 | DIRECT |
48179,48179
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
51556,51338
51556 - Metallo-dependent hydrolases
51338 - Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
82615,82615
82615 - Polo-box domain
82615 - Polo-box domain | 0 | DIRECT |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0 | DIRECT |
51045,51045
51045 - WW domain
51045 - WW domain | 0 | DIRECT |
52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | DIRECT |
54495,46934
54495 - UBC-like
46934 - UBA-like | 0 | DIRECT |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0 | DIRECT |
81301,81631
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain | 0 | DIRECT |
55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | DIRECT |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | DIRECT |
141673,50800
141673 - MOSC N-terminal domain-like
50800 - PK beta-barrel domain-like | 0 | DIRECT |
81698,81698
81698 - FF domain
81698 - FF domain | 0 | DIRECT |
53187,49464
53187 - Zn-dependent exopeptidases
49464 - Carboxypeptidase regulatory domain-like | 0 | DIRECT |
53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | DIRECT |
81631,55003
81631 - PAP/OAS1 substrate-binding domain
55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | DIRECT |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0 | DIRECT |
57362,57362
57362 - BPTI-like
57362 - BPTI-like | 0 | DIRECT |
81333,81333
81333 - F1F0 ATP synthase subunit C
81333 - F1F0 ATP synthase subunit C | 0 | DIRECT |
48403,52151
48403 - Ankyrin repeat
52151 - FabD/lysophospholipase-like | 0 | DIRECT |
52047,48371
52047 - RNI-like
48371 - ARM repeat | 0 | DIRECT |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0 | DIRECT |
51905,56425
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
101690,53098
101690 - PAZ domain
53098 - Ribonuclease H-like | 0 | DIRECT |
57903,82199
57903 - FYVE/PHD zinc finger
82199 - SET domain | 0 | DIRECT |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0 | DIRECT |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | DIRECT |
57196,63825
57196 - EGF/Laminin
63825 - YWTD domain | 0 | DIRECT |
53474,53474
53474 - alpha/beta-Hydrolases
53474 - alpha/beta-Hydrolases | 0 | DIRECT |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
55729,55729
55729 - Acyl-CoA N-acyltransferases (Nat)
55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | DIRECT |
52047,52047
52047 - RNI-like
52047 - RNI-like | 0 | DIRECT |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
52540,81271
52540 - P-loop containing nucleoside triphosphate hydrolases
81271 - TGS-like | 0 | DIRECT |
48464,89009
48464 - ENTH/VHS domain
89009 - GAT-like domain | 0 | DIRECT |
50249,55681
50249 - Nucleic acid-binding proteins
55681 - Class II aaRS and biotin synthetases | 0 | DIRECT |
56112,82615
56112 - Protein kinase-like (PK-like)
82615 - Polo-box domain | 0 | DIRECT |
50156,50044
50156 - PDZ domain-like
50044 - SH3-domain | 0 | DIRECT |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | DIRECT |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
54695,81382
54695 - POZ domain
81382 - Skp1 dimerisation domain-like | 0 | DIRECT |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0 | DIRECT |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0 | DIRECT |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | DIRECT |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
55326,56042
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like | 0 | DIRECT |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | DIRECT |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | DIRECT |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | DIRECT |
52540,90123
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0 | DIRECT |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | DIRECT |
57889,48350
57889 - Cysteine-rich domain
48350 - GTPase activation domain, GAP | 0 | DIRECT |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | DIRECT |
48425,50729
48425 - Sec7 domain
50729 - PH domain-like | 0 | DIRECT |
74650,51445
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases | 0 | DIRECT |
68923,53795
68923 - PEP carboxykinase N-terminal domain
53795 - PEP carboxykinase-like | 0 | DIRECT |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0 | DIRECT |
57756,57756
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains | 0 | DIRECT |
57863,48403
57863 - ArfGap/RecO-like zinc finger
48403 - Ankyrin repeat | 0 | DIRECT |
47741,56176
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like | 0 | DIRECT |
81383,50978
81383 - F-box domain
50978 - WD40 repeat-like | 0 | DIRECT |
49493,49493
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
51735,50129
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | DIRECT |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | DIRECT |
56059,52210
56059 - Glutathione synthetase ATP-binding domain-like
52210 - Succinyl-CoA synthetase domains | 0 | DIRECT |
81324,81296
81324 - Voltage-gated potassium channels
81296 - E set domains | 0 | DIRECT |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0 | DIRECT |
51338,51556
51338 - Composite domain of metallo-dependent hydrolases
51556 - Metallo-dependent hydrolases | 0 | DIRECT |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
51445,51011
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0 | DIRECT |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
141739,141739
141739 - MFPT repeat-like
141739 - MFPT repeat-like | 0 | DIRECT |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | DIRECT |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | DIRECT |
52540,140990
52540 - P-loop containing nucleoside triphosphate hydrolases
140990 - FtsH protease domain-like | 0 | DIRECT |
57625,57625
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins | 0 | DIRECT |
47576,47576
47576 - Calponin-homology domain, CH-domain
47576 - Calponin-homology domain, CH-domain | 0 | DIRECT |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0 | DIRECT |
52440,56059
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.003231 | INHERITED FROM: slow growth || dauer lifespan variant || organism UV hypersensitive || organism UV response variant || organism stress response variant || dauer lifespan extended || sick || organism environmental stimulus response variant |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.01868 | INHERITED FROM: aldicarb resistant || slow growth || acetylcholinesterase inhibitor resistant |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.1301 | INHERITED FROM: aqueous chemosensory response variant || chemotaxis variant || dauer defective || gene expression variant || positive chemotaxis defective || aldicarb response variant || pattern of transgene expression variant || organism environmental stimulus response variant |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1339 | INHERITED FROM: colchicine hypersensitive || metal response variant || cadmium response variant || RNAi response variant || organism environmental stimulus response variant |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0.1589 | INHERITED FROM: nicotine hypersensitive || lipid composition variant || organism environmental stimulus response variant |
56112,55073
56112 - Protein kinase-like (PK-like)
55073 - Nucleotide cyclase | 0.1589 | INHERITED FROM: lithium chemotaxis defective || iodide chemotaxis defective || chemosensory response variant || aqueous chemosensory response variant || bromide chemotaxis variant || cation positive chemotaxis defective || chemotaxis variant || iodide chemotaxis variant || benzaldehyde chemotaxis variant || magnesium chemotaxis defective || anion positive chemotaxis defective || AWC odorant chemotaxis defective || alkaline pH chemotaxis variant || anion positive chemotaxis variant || AWC odorant chemotaxis variant || positive chemotaxis variant || cation positive chemotaxis variant || bromide chemotaxis defective || organism environmental stimulus response variant || chemical response variant |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0.2039 | INHERITED FROM: cadmium hypersensitive |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0.2355 | INHERITED FROM: transgene expression variant || protein phosphorylation increased || protein protein interaction variant || protein phosphorylation variant || proteasome core activity variant || protein modification variant || protein aggregation variant || mRNA levels increased || mRNA levels reduced |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.2856 | INHERITED FROM: lipid metabolism variant || fat content variant |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.2856 | INHERITED FROM: nicotine hypersensitive || organism environmental stimulus response variant |
56436,49854
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain | 0.2887 | INHERITED FROM: cadmium response variant || cadmium hypersensitive |
49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0.3139 | INHERITED FROM: protein interaction variant || protein protein interaction variant || protein aggregation variant |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.3456 | INHERITED FROM: protein interaction variant || protein protein interaction variant || pattern of transgene expression variant || protein aggregation variant |
50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0.3456 | INHERITED FROM: aqueous positive chemotaxis variant || mechanosensation variant || aqueous chemosensory response variant || odorant chemosensory response variant || chemotaxis variant || dauer defective || positive chemotaxis variant || osmotic avoidance variant || positive chemotaxis defective || aqueous positive chemotaxis defective || negative chemotaxis variant |
47473,47473
47473 - EF-hand
47473 - EF-hand | 0.3801 | INHERITED FROM: acetylcholinesterase inhibitor response variant || acetylcholinesterase inhibitor hypersensitive || aldicarb response variant |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.4098 | INHERITED FROM: late larval arrest || starvation induced apoptosis variant || gene expression variant || organism starvation response variant |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.4665 | INHERITED FROM: mechanosensation variant || hypoosmotic shock hypersensitive || aqueous chemosensory response variant || antihelmintic response variant || nicotine resistant || cholinergic agonist resistant || drug response variant || selenium response variant || positive chemotaxis variant || DMPP response variant || sodium chloride chemotaxis variant || organism environmental stimulus response variant || chemical response variant || protein degradation variant |
48403,48403
48403 - Ankyrin repeat
48403 - Ankyrin repeat | 0.5016 | INHERITED FROM: organism environmental stimulus response variant |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.5276 | INHERITED FROM: organism metabolism processing variant || protein expression reduced || protein expression variant |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.5365 | INHERITED FROM: growth rate variant || protein expression reduced |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.5733 | INHERITED FROM: paraquat response variant || metal response variant || cadmium response variant || enzyme activity reduced || organism electrophilic stress hypersensitive || enzyme activity variant || organism stress response variant || organism heat hypersensitive || cadmium hypersensitive || organism environmental stimulus response variant |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.5998 | INHERITED FROM: protein expression reduced |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.6114 | INHERITED FROM: transgene expression reduced || chemical hypersensitive || SDS sensitive dauer || dauer resistance to harsh conditions variant |
63380,52343
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.6566 | INHERITED FROM: transgene subcellular localization variant |
48431,56968
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.6566 | INHERITED FROM: transgene subcellular localization variant || pathogen susceptibility increased || life span variant || organism pathogen response variant || organism environmental stimulus response variant |
56968,48431
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain | 0.6566 | INHERITED FROM: transgene subcellular localization variant || pathogen susceptibility increased || life span variant || organism pathogen response variant || organism environmental stimulus response variant |
57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.7038 | INHERITED FROM: protein expression reduced |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0.7038 | INHERITED FROM: life span variant || shortened life span |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0.719 | INHERITED FROM: organism UV hypersensitive || organism UV response variant || organism environmental stimulus response variant |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0.7861 | INHERITED FROM: level of protein expression variant || protein expression reduced || protein expression variant |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.8764 | INHERITED FROM: aldicarb resistant || growth rate variant || chemical response variant || protein degradation variant |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.9281 | INHERITED FROM: growth rate variant || protein degradation variant |
54211,55666
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like | 0.9648 | INHERITED FROM: early larval arrest |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.9756 | INHERITED FROM: drug resistant |
57850,57850
57850 - RING/U-box
57850 - RING/U-box | 1 | INHERITED FROM: transgene subcellular localization variant || protein interaction variant || protein protein interaction variant || pattern of transgene expression variant || protein aggregation variant |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 1 | INHERITED FROM: lipid metabolism variant || fat content variant |
57850,57845
57850 - RING/U-box
57845 - B-box zinc-binding domain | 1 | INHERITED FROM: transgene subcellular localization variant || protein interaction variant || protein protein interaction variant || protein aggregation variant |
53300,56436
53300 - vWA-like
56436 - C-type lectin-like | 1 | INHERITED FROM: pathogen susceptibility increased || pathogen induced death increased |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0 | Direct |
103473,103473
103473 - MFS general substrate transporter
103473 - MFS general substrate transporter | 0 | Direct |
57889,50729
57889 - Cysteine-rich domain
50729 - PH domain-like | 0 | Direct |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0 | Direct |
50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | Direct |
46785,46785
46785 - "Winged helix" DNA-binding domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
53738,55957
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | Direct |
52283,51735
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | Direct |
51445,54556
51445 - (Trans)glycosidases
54556 - Chitinase insertion domain | 0 | Direct |
50044,52540
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | Direct |
55920,46785
55920 - Creatinase/aminopeptidase
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
56112,48371
56112 - Protein kinase-like (PK-like)
48371 - ARM repeat | 0 | Direct |
56601,48403
56601 - beta-lactamase/transpeptidase-like
48403 - Ankyrin repeat | 0 | Direct |
81324,81327
81324 - Voltage-gated potassium channels
81327 - Small-conductance potassium channel | 0 | Direct |
50978,50998
50978 - WD40 repeat-like
50998 - Quinoprotein alcohol dehydrogenase-like | 0 | Direct |
51971,54373
51971 - Nucleotide-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0 | Direct |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
54897,53187
54897 - Protease propeptides/inhibitors
53187 - Zn-dependent exopeptidases | 0 | Direct |
50044,50044
50044 - SH3-domain
50044 - SH3-domain | 0 | Direct |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0 | Direct |
161111,160240
161111 - Cation efflux protein transmembrane domain-like
160240 - Cation efflux protein cytoplasmic domain-like | 0 | Direct |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | Direct |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | Direct |
64356,49447
64356 - SNARE-like
49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
54292,47741
54292 - 2Fe-2S ferredoxin-like
47741 - CO dehydrogenase ISP C-domain like | 0 | Direct |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0 | Direct |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0 | Direct |
81383,52047
81383 - F-box domain
52047 - RNI-like | 0 | Direct |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
47587,56399
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | Direct |
56672,100879
56672 - DNA/RNA polymerases
100879 - Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
57756,50630
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases | 0 | Direct |
161093,161093
161093 - MgtE membrane domain-like
161093 - MgtE membrane domain-like | 0 | Direct |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | Direct |
51735,55347
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | Direct |
54211,55060
54211 - Ribosomal protein S5 domain 2-like
55060 - GHMP Kinase, C-terminal domain | 0 | Direct |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | Direct |
57414,57414
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like | 0 | Direct |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | Direct |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
54665,56003
54665 - CO dehydrogenase molybdoprotein N-domain-like
56003 - Molybdenum cofactor-binding domain | 0 | Direct |
81324,53850
81324 - Voltage-gated potassium channels
53850 - Periplasmic binding protein-like II | 0 | Direct |
88713,88688
88713 - Glycoside hydrolase/deacetylase
88688 - Families 57/38 glycoside transferase middle domain | 0 | Direct |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0 | Direct |
51445,51445
51445 - (Trans)glycosidases
51445 - (Trans)glycosidases | 0 | Direct |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
52113,52113
52113 - BRCT domain
52113 - BRCT domain | 0 | Direct |
53901,53901
53901 - Thiolase-like
53901 - Thiolase-like | 0 | Direct |
55394,55394
55394 - Bactericidal permeability-increasing protein, BPI
55394 - Bactericidal permeability-increasing protein, BPI | 0 | Direct |
47473,103506
47473 - EF-hand
103506 - Mitochondrial carrier | 0 | Direct |
46938,52087
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain | 0 | Direct |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | Direct |
82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | Direct |
47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | Direct |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | Direct |
49742,49742
49742 - PHM/PNGase F
49742 - PHM/PNGase F | 0 | Direct |
53187,55031
53187 - Zn-dependent exopeptidases
55031 - Bacterial exopeptidase dimerisation domain | 0 | Direct |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
47203,47203
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
144232,82199
144232 - HIT/MYND zinc finger-like
82199 - SET domain | 0 | Direct |
57850,117839
57850 - RING/U-box
117839 - WWE domain | 0 | Direct |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | Direct |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
57938,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
51735,56327
51735 - NAD(P)-binding Rossmann-fold domains
56327 - LDH C-terminal domain-like | 0 | Direct |
54236,54236
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0 | Direct |
48179,48179
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
51556,51338
51556 - Metallo-dependent hydrolases
51338 - Composite domain of metallo-dependent hydrolases | 0 | Direct |
82615,82615
82615 - Polo-box domain
82615 - Polo-box domain | 0 | Direct |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0 | Direct |
51045,51045
51045 - WW domain
51045 - WW domain | 0 | Direct |
52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | Direct |
54495,46934
54495 - UBC-like
46934 - UBA-like | 0 | Direct |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0 | Direct |
81301,81631
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain | 0 | Direct |
55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | Direct |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | Direct |
141673,50800
141673 - MOSC N-terminal domain-like
50800 - PK beta-barrel domain-like | 0 | Direct |
81698,81698
81698 - FF domain
81698 - FF domain | 0 | Direct |
53187,49464
53187 - Zn-dependent exopeptidases
49464 - Carboxypeptidase regulatory domain-like | 0 | Direct |
53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | Direct |
81631,55003
81631 - PAP/OAS1 substrate-binding domain
55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | Direct |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0 | Direct |
57362,57362
57362 - BPTI-like
57362 - BPTI-like | 0 | Direct |
81333,81333
81333 - F1F0 ATP synthase subunit C
81333 - F1F0 ATP synthase subunit C | 0 | Direct |
48403,52151
48403 - Ankyrin repeat
52151 - FabD/lysophospholipase-like | 0 | Direct |
52047,48371
52047 - RNI-like
48371 - ARM repeat | 0 | Direct |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0 | Direct |
51905,56425
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
101690,53098
101690 - PAZ domain
53098 - Ribonuclease H-like | 0 | Direct |
57903,82199
57903 - FYVE/PHD zinc finger
82199 - SET domain | 0 | Direct |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0 | Direct |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0 | Direct |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | Direct |
57196,63825
57196 - EGF/Laminin
63825 - YWTD domain | 0 | Direct |
53474,53474
53474 - alpha/beta-Hydrolases
53474 - alpha/beta-Hydrolases | 0 | Direct |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0 | Direct |
55729,55729
55729 - Acyl-CoA N-acyltransferases (Nat)
55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | Direct |
52047,52047
52047 - RNI-like
52047 - RNI-like | 0 | Direct |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | Direct |
52540,81271
52540 - P-loop containing nucleoside triphosphate hydrolases
81271 - TGS-like | 0 | Direct |
48464,89009
48464 - ENTH/VHS domain
89009 - GAT-like domain | 0 | Direct |
50249,55681
50249 - Nucleic acid-binding proteins
55681 - Class II aaRS and biotin synthetases | 0 | Direct |
56112,82615
56112 - Protein kinase-like (PK-like)
82615 - Polo-box domain | 0 | Direct |
50156,50044
50156 - PDZ domain-like
50044 - SH3-domain | 0 | Direct |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | Direct |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
54695,81382
54695 - POZ domain
81382 - Skp1 dimerisation domain-like | 0 | Direct |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0 | Direct |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0 | Direct |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0 | Direct |
54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | Direct |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
55326,56042
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like | 0 | Direct |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | Direct |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | Direct |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | Direct |
52540,90123
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0 | Direct |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | Direct |
57889,48350
57889 - Cysteine-rich domain
48350 - GTPase activation domain, GAP | 0 | Direct |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | Direct |
48425,50729
48425 - Sec7 domain
50729 - PH domain-like | 0 | Direct |
74650,51445
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases | 0 | Direct |
68923,53795
68923 - PEP carboxykinase N-terminal domain
53795 - PEP carboxykinase-like | 0 | Direct |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0 | Direct |
57756,57756
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains | 0 | Direct |
57863,48403
57863 - ArfGap/RecO-like zinc finger
48403 - Ankyrin repeat | 0 | Direct |
47741,56176
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like | 0 | Direct |
81383,50978
81383 - F-box domain
50978 - WD40 repeat-like | 0 | Direct |
49493,49493
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
51735,50129
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | Direct |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | Direct |
56059,52210
56059 - Glutathione synthetase ATP-binding domain-like
52210 - Succinyl-CoA synthetase domains | 0 | Direct |
81324,81296
81324 - Voltage-gated potassium channels
81296 - E set domains | 0 | Direct |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0 | Direct |
51338,51556
51338 - Composite domain of metallo-dependent hydrolases
51556 - Metallo-dependent hydrolases | 0 | Direct |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | Direct |
51445,51011
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0 | Direct |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
141739,141739
141739 - MFPT repeat-like
141739 - MFPT repeat-like | 0 | Direct |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | Direct |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | Direct |
52540,140990
52540 - P-loop containing nucleoside triphosphate hydrolases
140990 - FtsH protease domain-like | 0 | Direct |
57625,57625
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins | 0 | Direct |
47576,47576
47576 - Calponin-homology domain, CH-domain
47576 - Calponin-homology domain, CH-domain | 0 | Direct |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0 | Direct |
52440,56059
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 0 | Direct |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.003231 | Inherited |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.01868 | Inherited |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.1301 | Inherited |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1339 | Inherited |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0.1589 | Inherited |
56112,55073
56112 - Protein kinase-like (PK-like)
55073 - Nucleotide cyclase | 0.1589 | Inherited |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0.2039 | Inherited |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0.2355 | Inherited |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.2856 | Inherited |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.2856 | Inherited |
56436,49854
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain | 0.2887 | Inherited |
49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0.3139 | Inherited |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.3456 | Inherited |
50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0.3456 | Inherited |
47473,47473
47473 - EF-hand
47473 - EF-hand | 0.3801 | Inherited |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.4098 | Inherited |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.4665 | Inherited |
48403,48403
48403 - Ankyrin repeat
48403 - Ankyrin repeat | 0.5016 | Inherited |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.5276 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.5365 | Inherited |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.5733 | Inherited |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.5998 | Inherited |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.6114 | Inherited |
63380,52343
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.6566 | Inherited |
48431,56968
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.6566 | Inherited |
56968,48431
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain | 0.6566 | Inherited |
57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.7038 | Inherited |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0.7038 | Inherited |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0.719 | Inherited |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0.7861 | Inherited |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.8764 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.9281 | Inherited |
54211,55666
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like | 0.9648 | Inherited |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.9756 | Inherited |
57850,57850
57850 - RING/U-box
57850 - RING/U-box | 1 | Inherited |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 1 | Inherited |
57850,57845
57850 - RING/U-box
57845 - B-box zinc-binding domain | 1 | Inherited |
53300,56436
53300 - vWA-like
56436 - C-type lectin-like | 1 | Inherited |
(show details)
Supra-domains annotated to this WP term (Not in SPWP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
55973,55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | DIRECT |
48726,49265,48726
48726 - Immunoglobulin
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | DIRECT |
53738,53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | DIRECT |
57625,57625,57625
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins | 0 | DIRECT |
56436,49854,49854
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
46938,52087,101576
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain
101576 - Supernatant protein factor (SPF), C-terminal domain | 0 | DIRECT |
48452,48452,48452
48452 - TPR-like
48452 - TPR-like
48452 - TPR-like | 0 | DIRECT |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52540,90123,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
56645,47203,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
57938,49493,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | DIRECT |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0 | DIRECT |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | DIRECT |
50156,50044,52540
50156 - PDZ domain-like
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
81301,81631,55003
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain
55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | DIRECT |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | DIRECT |
56112,82615,82615
56112 - Protein kinase-like (PK-like)
82615 - Polo-box domain
82615 - Polo-box domain | 0 | DIRECT |
74650,51445,51011
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0 | DIRECT |
57414,57414,57414
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like | 0 | DIRECT |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | DIRECT |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
63411,63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0 | DIRECT |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
57362,57362,57362
57362 - BPTI-like
57362 - BPTI-like
57362 - BPTI-like | 0 | DIRECT |
90123,52540,90123
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0 | DIRECT |
50044,50044,50044
50044 - SH3-domain
50044 - SH3-domain
50044 - SH3-domain | 0 | DIRECT |
51735,48179,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
50249,50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
54292,47741,56176
54292 - 2Fe-2S ferredoxin-like
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like | 0 | DIRECT |
57567,57567,57567
57567 - Serine protease inhibitors
57567 - Serine protease inhibitors
57567 - Serine protease inhibitors | 0 | DIRECT |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
49785,49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
82895,82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
54928,54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0 | DIRECT |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0 | DIRECT |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0 | DIRECT |
53738,53738,55957
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
50129,51735,50129
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | DIRECT |
48371,48371,48371
48371 - ARM repeat
48371 - ARM repeat
48371 - ARM repeat | 0 | DIRECT |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.1754 | INHERITED FROM: nicotine hypersensitive || lipid composition variant || organism environmental stimulus response variant |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.4171 | INHERITED FROM: level of protein expression variant || protein metabolism variant || protein expression reduced |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.4171 | INHERITED FROM: protein interaction variant || protein protein interaction variant || pattern of transgene expression variant || protein aggregation variant |
56436,56436,49854
56436 - C-type lectin-like
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain | 0.4367 | INHERITED FROM: metal response variant || cadmium response variant || cadmium hypersensitive |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.5016 | INHERITED FROM: level of protein expression variant || organism metabolism processing variant || protein metabolism variant || protein expression reduced || protein expression variant || protein degradation variant |
56968,48431,56968
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.6566 | INHERITED FROM: transgene subcellular localization variant || pathogen susceptibility increased || life span variant || organism pathogen response variant || organism environmental stimulus response variant |
57850,57850,57850
57850 - RING/U-box
57850 - RING/U-box
57850 - RING/U-box | 0.8957 | INHERITED FROM: transgene subcellular localization variant || transgene expression variant || protein interaction variant || gene expression variant || protein protein interaction variant || pattern of transgene expression variant || protein aggregation variant |
57667,57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 1 | INHERITED FROM: level of transgene expression variant |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 1 | INHERITED FROM: growth rate variant || protein degradation variant |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 1 | INHERITED FROM: growth rate variant || protein degradation variant |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
55973,55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | Direct |
48726,49265,48726
48726 - Immunoglobulin
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | Direct |
53738,53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | Direct |
57625,57625,57625
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins | 0 | Direct |
56436,49854,49854
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | Direct |
46938,52087,101576
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain
101576 - Supernatant protein factor (SPF), C-terminal domain | 0 | Direct |
48452,48452,48452
48452 - TPR-like
48452 - TPR-like
48452 - TPR-like | 0 | Direct |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52540,90123,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
56645,47203,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
57938,49493,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | Direct |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0 | Direct |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | Direct |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | Direct |
50156,50044,52540
50156 - PDZ domain-like
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
81301,81631,55003
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain
55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | Direct |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | Direct |
56112,82615,82615
56112 - Protein kinase-like (PK-like)
82615 - Polo-box domain
82615 - Polo-box domain | 0 | Direct |
74650,51445,51011
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0 | Direct |
57414,57414,57414
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like | 0 | Direct |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | Direct |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
63411,63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0 | Direct |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
57362,57362,57362
57362 - BPTI-like
57362 - BPTI-like
57362 - BPTI-like | 0 | Direct |
90123,52540,90123
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0 | Direct |
50044,50044,50044
50044 - SH3-domain
50044 - SH3-domain
50044 - SH3-domain | 0 | Direct |
51735,48179,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
50249,50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | Direct |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
54292,47741,56176
54292 - 2Fe-2S ferredoxin-like
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like | 0 | Direct |
57567,57567,57567
57567 - Serine protease inhibitors
57567 - Serine protease inhibitors
57567 - Serine protease inhibitors | 0 | Direct |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | Direct |
49785,49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0 | Direct |
82895,82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | Direct |
54928,54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0 | Direct |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0 | Direct |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0 | Direct |
53738,53738,55957
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | Direct |
50129,51735,50129
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | Direct |
48371,48371,48371
48371 - ARM repeat
48371 - ARM repeat
48371 - ARM repeat | 0 | Direct |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.1754 | Inherited |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.4171 | Inherited |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.4171 | Inherited |
56436,56436,49854
56436 - C-type lectin-like
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain | 0.4367 | Inherited |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.5016 | Inherited |
56968,48431,56968
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.6566 | Inherited |
57850,57850,57850
57850 - RING/U-box
57850 - RING/U-box
57850 - RING/U-box | 0.8957 | Inherited |
57667,57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 1 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 1 | Inherited |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 1 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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