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Worm Phenotype (WP): organism physiology variant
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Integrin alpha N-terminal domain | 0 | DIRECT |
| Cytochrome c | 0 | DIRECT |
| Class II aaRS ABD-related | 0 | DIRECT |
| FAD-linked oxidases, C-terminal domain | 0 | DIRECT |
| JAB1/MPN domain | 0 | DIRECT |
| BEACH domain | 0 | DIRECT |
| Ferritin-like | 0 | DIRECT |
| ACP-like | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| VPS9 domain | 0 | DIRECT |
| dsRNA-binding domain-like | 0 | DIRECT |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
| Kringle-like | 0 | DIRECT |
| MFPT repeat-like | 0 | DIRECT |
| PEP carboxykinase-like | 0 | DIRECT |
| ADP-ribosylation | 0 | DIRECT |
| Families 57/38 glycoside transferase middle domain | 0 | DIRECT |
| Thyroglobulin type-1 domain | 0 | DIRECT |
| HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
| Intermediate filament protein, coiled coil region | 0 | DIRECT |
| GroEL apical domain-like | 0 | DIRECT |
| t-snare proteins | 0 | DIRECT |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
| Glycolipid transfer protein, GLTP | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Translational machinery components | 0 | DIRECT |
| alpha-catenin/vinculin-like | 0 | DIRECT |
| TGS-like | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| Tubulin nucleotide-binding domain-like | 0 | DIRECT |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0 | DIRECT |
| Nucleoporin domain | 0 | DIRECT |
| PEBP-like | 0 | DIRECT |
| L30e-like | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| Purine and uridine phosphorylases | 0 | DIRECT |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | DIRECT |
| ARID-like | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| Tim10-like | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| ArfGap/RecO-like zinc finger | 0 | DIRECT |
| Band 7/SPFH domain | 0 | DIRECT |
| Polo-box domain | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| FAD-binding/transporter-associated domain-like | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| Carboxypeptidase regulatory domain-like | 0 | DIRECT |
| PurM C-terminal domain-like | 0 | DIRECT |
| LDH C-terminal domain-like | 0 | DIRECT |
| Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
| Spectrin repeat | 0 | DIRECT |
| Class I glutamine amidotransferase-like | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
| CO dehydrogenase ISP C-domain like | 0 | DIRECT |
| PABC (PABP) domain | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
| LysM domain | 0 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0 | DIRECT |
| Molybdenum cofactor-binding domain | 0 | DIRECT |
| Cadherin-like | 0 | DIRECT |
| Skp1 dimerisation domain-like | 0 | DIRECT |
| Acyl-CoA dehydrogenase NM domain-like | 0 | DIRECT |
| Troponin coil-coiled subunits | 0 | DIRECT |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | DIRECT |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | DIRECT |
| LEM domain | 0 | DIRECT |
| Profilin (actin-binding protein) | 0 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
| Chitinase insertion domain | 0 | DIRECT |
| Small-conductance potassium channel | 0 | DIRECT |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | DIRECT |
| Galactose mutarotase-like | 0 | DIRECT |
| Outer arm dynein light chain 1 | 0 | DIRECT |
| Tubulin C-terminal domain-like | 0 | DIRECT |
| HCP-like | 0 | DIRECT |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | DIRECT |
| R3H domain | 0 | DIRECT |
| Subtilisin-like | 0 | DIRECT |
| beta-lactamase/transpeptidase-like | 0 | DIRECT |
| cAMP-binding domain-like | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| SCP-like | 0 | DIRECT |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
| Thiolase-like | 0 | DIRECT |
| CBD9-like | 0 | DIRECT |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| Heme-dependent catalase-like | 0 | DIRECT |
| HRDC-like | 0 | DIRECT |
| Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
| 2Fe-2S ferredoxin-like | 0 | DIRECT |
| Tubby C-terminal domain-like | 0 | DIRECT |
| Surp module (SWAP domain) | 0 | DIRECT |
| Citrate synthase | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| PK beta-barrel domain-like | 0 | DIRECT |
| SIS domain | 0 | DIRECT |
| Aquaporin-like | 0 | DIRECT |
| YbiA-like | 0 | DIRECT |
| Protease propeptides/inhibitors | 0 | DIRECT |
| PGBD-like | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| PAP/OAS1 substrate-binding domain | 0 | DIRECT |
| lambda repressor-like DNA-binding domains | 0 | DIRECT |
| GAS2 domain-like | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Acetyl-CoA synthetase-like | 0 | DIRECT |
| Invertebrate chitin-binding proteins | 0 | DIRECT |
| Rap/Ran-GAP | 0 | DIRECT |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
| YWTD domain | 0 | DIRECT |
| RBP11-like subunits of RNA polymerase | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| MOSC N-terminal domain-like | 0 | DIRECT |
| Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
| Ribosomal L27 protein-like | 0 | DIRECT |
| Zn-binding ribosomal proteins | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Sec7 domain | 0 | DIRECT |
| Ribosomal proteins S24e, L23 and L15e | 0 | DIRECT |
| CAD & PB1 domains | 0 | DIRECT |
| AN1-like Zinc finger | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Doublecortin (DC) | 0 | DIRECT |
| Ribosomal protein L1 | 0 | DIRECT |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | DIRECT |
| SAICAR synthase-like | 0 | DIRECT |
| Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
| Ribosomal protein S10 | 0 | DIRECT |
| GroEL equatorial domain-like | 0 | DIRECT |
| PurM N-terminal domain-like | 0 | DIRECT |
| Activating enzymes of the ubiquitin-like proteins | 0 | DIRECT |
| WGR domain-like | 0 | DIRECT |
| Ribosomal protein S18 | 0 | DIRECT |
| L-aspartase-like | 0 | DIRECT |
| Annexin | 0 | DIRECT |
| Phoshotransferase/anion transport protein | 0 | DIRECT |
| Galactose oxidase, central domain | 0 | DIRECT |
| alpha/beta knot | 0 | DIRECT |
| MgtE membrane domain-like | 0 | DIRECT |
| PIN domain-like | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| Retrovirus zinc finger-like domains | 0 | DIRECT |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Elafin-like | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
| ISP domain | 0 | DIRECT |
| Nucleoside diphosphate kinase, NDK | 0 | DIRECT |
| Carbonic anhydrase | 0 | DIRECT |
| Chromo domain-like | 0 | DIRECT |
| NagB/RpiA/CoA transferase-like | 0 | DIRECT |
| S-adenosylmethionine synthetase | 0 | DIRECT |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | DIRECT |
| Radical SAM enzymes | 0 | DIRECT |
| Molybdenum cofactor biosynthesis proteins | 0 | DIRECT |
| TK C-terminal domain-like | 0 | DIRECT |
| Mitochondrial carrier | 0 | DIRECT |
| Cystatin/monellin | 0 | DIRECT |
| Fibrinogen C-terminal domain-like | 0 | DIRECT |
| Creatinase/prolidase N-terminal domain | 0 | DIRECT |
| Terpenoid synthases | 0 | DIRECT |
| CRAL/TRIO N-terminal domain | 0 | DIRECT |
| GAT-like domain | 0 | DIRECT |
| Cdc48 domain 2-like | 0 | DIRECT |
| GYF domain | 0 | DIRECT |
| Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
| Cullin repeat-like | 0 | DIRECT |
| Oxysterol-binding protein-like | 0 | DIRECT |
| PUA domain-like | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| PLC-like phosphodiesterases | 0 | DIRECT |
| Hormone receptor domain | 0 | DIRECT |
| Sec63 N-terminal domain-like | 0 | DIRECT |
| Histone-fold | 0 | DIRECT |
| eIF4e-like | 0 | DIRECT |
| SAND domain-like | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| Hedgehog/intein (Hint) domain | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| DNA repair protein MutS, domain III | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| Putative DNA-binding domain | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| Complement control module/SCR domain | 0 | DIRECT |
| PHM/PNGase F | 0 | DIRECT |
| Pepsin inhibitor-3 | 0 | DIRECT |
| Actin-like ATPase domain | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Rudiment single hybrid motif | 0 | DIRECT |
| WWE domain | 0 | DIRECT |
| Single hybrid motif | 0 | DIRECT |
| GroEL-intermediate domain like | 0 | DIRECT |
| Carbohydrate phosphatase | 0 | DIRECT |
| Aldolase | 0 | DIRECT |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
| PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | DIRECT |
| Ribokinase-like | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| Pentein | 0 | DIRECT |
| ThrRS/AlaRS common domain | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| Clc chloride channel | 0 | DIRECT |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| DEATH domain | 0 | DIRECT |
| GroES-like | 0 | DIRECT |
| Periplasmic binding protein-like II | 0 | DIRECT |
| Arginase/deacetylase | 0 | DIRECT |
| Restriction endonuclease-like | 0 | DIRECT |
| Heme-dependent peroxidases | 0 | DIRECT |
| Carbon-nitrogen hydrolase | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| Second domain of FERM | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| PreATP-grasp domain | 0 | DIRECT |
| ENTH/VHS domain | 0 | DIRECT |
| Chaperone J-domain | 0 | DIRECT |
| Diaminopimelate epimerase-like | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Ran binding protein zinc finger-like | 0 | DIRECT |
| Insulin-like | 0 | DIRECT |
| Ribosomal protein L10-like | 0 | DIRECT |
| Hypothetical protein c14orf129, hspc210 | 0 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
| PYP-like sensor domain (PAS domain) | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| Nucleotidyltransferase | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| HSP20-like chaperones | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| FtsH protease domain-like | 0 | DIRECT |
| Tricorn protease domain 2 | 0 | DIRECT |
| P-loop containing nucleoside triphosphate hydrolases | 0.0000004141 | DIRECT |
| PH domain-like | 0.00002159 | DIRECT |
| PapD-like | 0.009043 | INHERITED FROM: dauer metabolism variant || slow growth || dauer lifespan extended || larval growth variant || developmental growth variant || larval arrest || dauer lifespan variant || fat content variant || lipid metabolism variant |
| PDZ domain-like | 0.009221 | INHERITED FROM: drug resistant || aldicarb response variant || chemical resistant || protein expression variant || acetylcholinesterase inhibitor response variant |
| TPR-like | 0.01305 | INHERITED FROM: ivermectin resistant || antihelmintic response variant || light body touch resistant || chemotaxis variant || dauer development variant || ivermectin response variant || positive chemotaxis defective |
| Periplasmic binding protein-like I | 0.01452 | INHERITED FROM: second messenger mediated signaling variant || alkaline pH chemotaxis variant || iodide chemotaxis defective || iodide chemotaxis variant || AWC odorant chemotaxis variant || memory retention defective || benzaldehyde chemotaxis variant || chemosensory response variant || magnesium chemotaxis defective || diacetyl chemotaxis variant || mechanosensation variant || aqueous positive chemotaxis variant || aqueous chemosensory response variant || chemotaxis variant || carbon dioxide response variant || lithium chemotaxis defective || thermosensory behavior variant || carbon dioxide avoidance variant || AWC odorant chemotaxis defective || bromide chemotaxis defective || thermotaxis variant || organism environmental stimulus response variant || organism temperature response variant || bromide chemotaxis variant |
| ABC transporter transmembrane region | 0.02042 | INHERITED FROM: cadmium response variant || RNAi resistant || RNAi response variant || cadmium hypersensitive || chemical hypersensitive || metal response variant || chemical response variant || colchicine hypersensitive |
| ARM repeat | 0.02104 | INHERITED FROM: sexually dimorphic physiology variant || RNAi response variant || protein expression variant || organism metabolism processing variant || gene expression variant || sick |
| Protein kinase-like (PK-like) | 0.03839 | INHERITED FROM: second messenger mediated signaling variant || alkaline pH chemotaxis variant || mid larval arrest || life span variant || aldicarb response variant || protein subcellular localization variant || copper hypersensitive || organism oxidative stress response variant || organism osmotic stress hypersensitive || kinase activity reduced || drug induced gene expression variant || mechanosensation variant || conflicting sensory integration variant || aqueous chemosensory response variant || protein phosphorylation reduced || dauer development variant || protein modification variant || lipid synthesis increased || protein phosphorylation variant || metabolic pathway variant || protein expression variant || anoxia resistant || metal response variant || organism environmental stimulus response variant || egg laying response to food variant || chemical response variant || hypoxia response variant || octanol chemotaxis defective || positive chemotaxis variant || colchicine resistant || transgene expression reduced |
| Nucleic acid-binding proteins | 0.04851 | INHERITED FROM: hydroxyurea response variant || sexually dimorphic physiology variant || mRNA surveillance defective || nonsense mRNA accumulation || hypoxia resistant || avoids bacterial lawn || organism environmental stimulus response variant || hydroxyurea hypersensitive || sick || hermaphrodite physiology variant |
| SH3-domain | 0.04851 | INHERITED FROM: protein expression reduced || aldicarb response variant || protein phosphorylation variant || protein expression variant || protein metabolism variant |
| Homeodomain-like | 0.05532 | INHERITED FROM: ectopic expression transgene || imipramine resistant || level of transgene expression variant || growth rate variant || carbon dioxide response variant || carbon dioxide avoidance variant || phentolamine resistant || organism metabolism processing variant || adrenergic receptor antagonist response variant || protein degradation variant || egg laying imipramine resistant |
| WD40 repeat-like | 0.06563 | INHERITED FROM: protein protein interaction variant || sexually dimorphic physiology variant || aldicarb response variant || protein aggregation induced behavior variant || late larval arrest || protein aggregation variant || early larval arrest || osmotic avoidance variant || pathogen induced antimicrobial gene expression variant || organism metabolism processing variant || hermaphrodite physiology variant |
| CCCH zinc finger | 0.07001 | INHERITED FROM: ectopic expression transgene || transgene expression variant || gene expression variant || mRNA expression ectopic |
| FYVE/PHD zinc finger | 0.07992 | INHERITED FROM: organism UV hypersensitive || organism UV response variant || protein modification variant || organism metabolism processing variant || gene expression variant || protein methylation variant |
| Translation proteins | 0.08703 | INHERITED FROM: protein protein interaction variant || sexually dimorphic physiology variant || receptor mediated endocytosis defective || proteasome core activity variant || mRNA levels increased || protein phosphorylation increased || protein aggregation variant || transgene expression variant || oocyte physiology variant || protein phosphorylation variant || organism metabolism processing variant || gene expression variant || hermaphrodite physiology variant |
| "Winged helix" DNA-binding domain | 0.09848 | INHERITED FROM: life span variant || protein protein interaction variant || protein aggregation induced behavior variant || protein expression increased || anesthetic response variant || protein aggregation variant || spontaneous mutation rate increased || organism metabolism processing variant || germline transgene silencing variant |
| Nucleotide cyclase | 0.1021 | INHERITED FROM: second messenger mediated signaling variant || alkaline pH chemotaxis variant || iodide chemotaxis defective || iodide chemotaxis variant || AWC odorant chemotaxis variant || anion positive chemotaxis defective || anesthetic response variant || cation positive chemotaxis variant || cation positive chemotaxis defective || chemosensory response variant || magnesium chemotaxis defective || diacetyl chemotaxis variant || anion positive chemotaxis variant || aqueous chemosensory response variant || chemotaxis variant || carbon dioxide response variant || lithium chemotaxis defective || AWC odorant chemotaxis defective || bromide chemotaxis defective || osmotic avoidance variant || thermotaxis variant || organism environmental stimulus response variant || chemical response variant || positive chemotaxis variant || bromide chemotaxis variant |
| HLH, helix-loop-helix DNA-binding domain | 0.1021 | INHERITED FROM: ectopic expression transgene || gene expression level reduced || lysine chemotaxis defective || pathogen resistance increased || aqueous positive chemotaxis defective || organism metabolism processing variant || fungal resistance increased || hypoxia response variant || RNA expression variant |
| SMAD/FHA domain | 0.1083 | INHERITED FROM: dauer development variant || fat content reduced |
| Calcium ATPase, transmembrane domain M | 0.1208 | INHERITED FROM: nicotine hypersensitive || lipid composition variant || drug hypersensitive |
| Regulator of G-protein signaling, RGS | 0.1347 | INHERITED FROM: negative chemotaxis variant || mechanosensation variant || chemotaxis variant |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1347 | INHERITED FROM: nicotine hypersensitive || lipid composition variant || drug hypersensitive |
| EGF/Laminin | 0.1403 | INHERITED FROM: odorant negative chemotaxis defective || octanol chemotaxis variant || octanol chemotaxis defective |
| Acid proteases | 0.1498 | INHERITED FROM: protein protein interaction variant || transgene subcellular localization variant || hypoosmotic shock hypersensitive || osmotic integrity variant || protein aggregation variant || protein interaction variant || transgene expression variant || organism metabolism processing variant || gene expression variant |
| Calcium ATPase, transduction domain A | 0.1498 | INHERITED FROM: nicotine hypersensitive || drug hypersensitive || organism environmental stimulus response variant |
| Cysteine-rich domain | 0.1588 | INHERITED FROM: response to injury variant || aldicarb response variant || protein subcellular localization variant || pathogen induced gene expression variant || drug induced gene expression variant || antimicrobial gene expression variant || odorant chemosensory response variant || thermosensory behavior variant || bacterially unswollen || pathogen induced antimicrobial gene expression variant || odorant positive chemotaxis variant || thermotaxis variant || organism metabolism processing variant || gene expression variant || positive chemotaxis variant || acetylcholinesterase inhibitor response variant || organism stress response variant |
| Quinoprotein alcohol dehydrogenase-like | 0.1669 | INHERITED FROM: mid larval arrest || L2 arrest || mRNA levels increased || protein degradation variant || hypoxia response variant |
| Multidrug efflux transporter AcrB transmembrane domain | 0.1728 | INHERITED FROM: embryo osmotic integrity defective early emb || chemotaxis variant || odorant chemosensory response variant || odorant positive chemotaxis defective || egg integrity defective early emb || positive chemotaxis defective |
| HMG-box | 0.1857 | INHERITED FROM: anesthetic response variant || transgene expression variant || maintenance of gene silencing variant |
| DBL homology domain (DH-domain) | 0.1857 | INHERITED FROM: aldicarb response variant || pathogen resistance increased || bacterially unswollen || organism environmental stimulus response variant || response to bacteria variant || organism pathogen response variant |
| ClpP/crotonase | 0.1857 | INHERITED FROM: level of transgene expression variant || fat content variant || lipid metabolism variant |
| Cytochrome P450 | 0.1886 | INHERITED FROM: cadmium response variant || cadmium hypersensitive || metal response variant || metabolite content decreased |
| (Trans)glycosidases | 0.1994 | INHERITED FROM: pathogen susceptibility increased |
| Ankyrin repeat | 0.2154 | INHERITED FROM: organism heat response variant || odorant negative chemotaxis defective || chemosensory response variant || chemotaxis variant || octanol chemotaxis variant || octanol chemotaxis defective |
| Cyclin-like | 0.2409 | INHERITED FROM: protein phosphorylation reduced || protein phosphorylation variant |
| Cysteine proteinases | 0.2516 | INHERITED FROM: protein protein interaction variant || hypoosmotic shock hypersensitive || osmotic integrity variant || protein aggregation variant || protein interaction variant || paraquat hypersensitive || organism metabolism processing variant || pattern of transgene expression variant |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.2544 | INHERITED FROM: fat content variant || lipid metabolism variant |
| Bromodomain | 0.2544 | INHERITED FROM: organism UV hypersensitive || anesthetic response variant || ethanol resistant || drug adaptation variant || acute functional tolerance to alcohol defective || organism UV response variant || organism metabolism processing variant || gene expression variant || sick || anesthetic resistant |
| Tudor/PWWP/MBT | 0.2544 | INHERITED FROM: pattern of transgene expression variant |
| POZ domain | 0.2728 | INHERITED FROM: protein aggregation induced behavior variant || L1 arrest || resistant to protein aggregation induced paralysis || early larval arrest |
| SNARE-like | 0.2824 | INHERITED FROM: aldicarb resistant || transgene subcellular localization variant || transgene expression variant || acetylcholinesterase inhibitor resistant || organism metabolism processing variant || gene expression variant || pattern of transgene expression variant || sick |
| Lipocalins | 0.2826 | INHERITED FROM: fat content increased || paraquat hypersensitive || fat content variant || lipid metabolism variant |
| Metallo-dependent phosphatases | 0.2883 | INHERITED FROM: germ cell resistant ionizing radiation || radiation induced germ cell apoptosis variant |
| RNA-binding domain, RBD | 0.3043 | INHERITED FROM: starvation induced apoptosis variant || RNA processing variant || no induction of antimicrobial peptide expression after infection || mRNA export variant || alternative splicing variant || pathogen induced antimicrobial gene expression variant || organism metabolism processing variant || innate immune response variant || sick || maintenance of gene silencing variant || RNA metabolism variant || RNA expression variant |
| DNA/RNA polymerases | 0.3134 | INHERITED FROM: organism UV hypersensitive || DNA metabolism variant || organism UV response variant |
| Cation efflux protein transmembrane domain-like | 0.3469 | INHERITED FROM: manganese response variant || cadmium hypersensitive || manganese toxicity resistant || metal response variant |
| PX domain | 0.3469 | INHERITED FROM: protein expression reduced || protein subcellular localization variant || protein expression variant |
| Translation proteins SH3-like domain | 0.3469 | INHERITED FROM: transgene expression variant || early larval arrest || avoids bacterial lawn || organism metabolism processing variant || gene expression variant || organism environmental stimulus response variant || response to bacteria variant |
| HAD-like | 0.3705 | INHERITED FROM: nicotine hypersensitive |
| Nicotinic receptor ligand binding domain-like | 0.3863 | INHERITED FROM: AWC odorant chemotaxis variant || hypoosmotic shock hypersensitive || benzaldehyde chemotaxis variant || chemical resistant || chemosensory response variant || antihelmintic response variant || mechanosensation variant || nicotine resistant || sodium chloride chemotaxis variant || thermosensory behavior variant || DMPP resistant || DMPP response variant || drug response variant || thermotaxis variant || selenium response variant || slowing response on food variant || cholinergic agonist resistant || organism environmental stimulus response variant || chemical response variant || positive chemotaxis variant |
| PLP-dependent transferases | 0.3926 | INHERITED FROM: germ cell resistant ionizing radiation || radiation induced germ cell apoptosis variant |
| Ubiquitin-like | 0.4027 | INHERITED FROM: protein protein interaction variant || protein aggregation variant || protein interaction variant || heteroplasmy |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.4229 | INHERITED FROM: AWC odorant chemotaxis variant || hypoosmotic shock hypersensitive || benzaldehyde chemotaxis variant || chemical resistant || chemosensory response variant || antihelmintic response variant || mechanosensation variant || nicotine resistant || sodium chloride chemotaxis variant || thermosensory behavior variant || DMPP resistant || DMPP response variant || drug response variant || thermotaxis variant || selenium response variant || slowing response on food variant || cholinergic agonist resistant || organism environmental stimulus response variant || chemical response variant || positive chemotaxis variant |
| HD-domain/PDEase-like | 0.4236 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant || organism temperature response variant |
| FKBP-like | 0.4236 | INHERITED FROM: protein protein interaction variant || transgene subcellular localization variant || protein aggregation variant || protein interaction variant || pattern of transgene expression variant |
| RNI-like | 0.4258 | INHERITED FROM: resistant to protein aggregation induced paralysis |
| Class II aaRS and biotin synthetases | 0.4413 | INHERITED FROM: sexually dimorphic physiology variant || receptor mediated endocytosis defective || transgene expression variant || oocyte physiology variant || hypoxia resistant || avoids bacterial lawn || organism metabolism processing variant || gene expression variant || organism environmental stimulus response variant || oxygen response variant || response to bacteria variant || hypoxia response variant || hermaphrodite physiology variant |
| Hect, E3 ligase catalytic domain | 0.4686 | INHERITED FROM: protein protein interaction variant || germ cell ionizing radiation response variant || transgene subcellular localization variant || protein aggregation induced behavior variant || protein aggregation variant || protein interaction variant || transgene expression variant || cell ionizing radiation response variant || organism metabolism processing variant || gene expression variant || pattern of transgene expression variant |
| DHS-like NAD/FAD-binding domain | 0.4686 | INHERITED FROM: metabolic pathway variant || protein acetylation variant |
| Myosin rod fragments | 0.4686 | INHERITED FROM: drug resistant || sexually dimorphic physiology variant || hermaphrodite physiology variant |
| PRTase-like | 0.4686 | INHERITED FROM: drug resistant || Fluorouracil resistant |
| Ribosomal protein S5 domain 2-like | 0.5025 | INHERITED FROM: early larval arrest |
| Galactose-binding domain-like | 0.5025 | INHERITED FROM: protein protein interaction variant || protein aggregation variant || protein interaction variant |
| Sm-like ribonucleoproteins | 0.5054 | INHERITED FROM: life span variant || unfolded protein response variant || sexually dimorphic physiology variant || receptor mediated endocytosis defective || organism heat response variant || protein subcellular localization variant || transgene expression variant || avoids bacterial lawn || pattern of transgene expression variant || response to bacteria variant || sick || hermaphrodite physiology variant |
| Cystine-knot cytokines | 0.5054 | INHERITED FROM: levamisole response variant || nicotine response variant |
| SH2 domain | 0.5147 | INHERITED FROM: protein expression reduced || level of protein expression variant || protein expression variant |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.5152 | INHERITED FROM: pattern protein expression variant |
| Calpain large subunit, middle domain (domain III) | 0.5152 | INHERITED FROM: metabolic pathway variant || protein degradation variant || protein metabolism variant |
| Riboflavin synthase domain-like | 0.5152 | INHERITED FROM: pattern protein expression variant |
| FAD/NAD(P)-binding domain | 0.5317 | INHERITED FROM: life span variant || organism oxidative stress response variant || ATP levels reduced || ATP levels variant || pesticide response variant || organism toxic chemical response variant |
| WW domain | 0.5418 | INHERITED FROM: aldicarb resistant || maintenance of gene silencing variant |
| FAD-linked reductases, C-terminal domain | 0.5418 | INHERITED FROM: life span variant |
| Voltage-gated potassium channels | 0.5497 | INHERITED FROM: serotonin response variant || imipramine resistant || mechanosensation variant || growth rate variant || serotonin resistant || phentolamine resistant || adrenergic receptor antagonist response variant || protein degradation variant || positive chemotaxis defective |
| Nucleotidylyl transferase | 0.5508 | INHERITED FROM: paraquat resistant || transgene expression increased || hypoxia resistant || avoids bacterial lawn || organism metabolism processing variant || organism environmental stimulus response variant || oxygen response variant || response to bacteria variant || hypoxia response variant |
| SAM/Pointed domain | 0.5508 | INHERITED FROM: gene expression level reduced || aldicarb response variant |
| UBC-like | 0.5542 | INHERITED FROM: protein protein interaction variant || transgene subcellular localization variant || late larval arrest || protein aggregation variant || protein interaction variant || organism metabolism processing variant || pattern of transgene expression variant || sick |
| SET domain | 0.5542 | INHERITED FROM: life span variant || ectopic expression antibody || shortened life span || histone methylation variant || dosage compensation variant || spontaneous mutation rate increased || RNAi response variant || protein modification variant || organism metabolism processing variant || gene expression variant || pattern of transgene expression variant || maintenance of gene silencing variant || protein metabolism variant || protein methylation variant |
| Seven-hairpin glycosidases | 0.57 | INHERITED FROM: protein protein interaction variant || protein aggregation variant || extended life span |
| Multidrug resistance efflux transporter EmrE | 0.577 | INHERITED FROM: pathogen resistance increased || bacterially unswollen || response to bacteria variant |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.6146 | INHERITED FROM: response to injury variant || drug resistant || gonad sheath contractions variant || organism osmotic stress response variant || protein subcellular localization variant || aging variant || chemical resistant || somatic sheath physiology variant || drug induced gene expression variant || growth rate variant || cellular osmotic stress response variant || RNAi response variant || protein expression variant || pathogen induced antimicrobial gene expression variant || cell stress response variant || gonad sheath contraction rate reduced || organism environmental stimulus response variant || chemical response variant |
| Di-copper centre-containing domain | 0.6253 | INHERITED FROM: germ cell ionizing radiation response variant || organism ionizing radiation response variant || cell ionizing radiation response variant || cell stress response variant |
| KA1-like | 0.6253 | INHERITED FROM: RNA expression variant |
| Nucleotide-binding domain | 0.6253 | INHERITED FROM: extended life span |
| HIT/MYND zinc finger-like | 0.6534 | INHERITED FROM: pattern of transgene expression variant |
| S-adenosyl-L-methionine-dependent methyltransferases | 0.6626 | INHERITED FROM: gamma ray induced apoptosis increased || organism gamma ray response variant || cell gamma ray response variant |
| MFS general substrate transporter | 0.6635 | INHERITED FROM: organism high sodium chloride hypersensitive |
| Frizzled cysteine-rich domain | 0.6899 | INHERITED FROM: antibody staining variant || transgene expression reduced |
| S15/NS1 RNA-binding domain | 0.6899 | INHERITED FROM: transgene expression increased || avoids bacterial lawn || response to bacteria variant |
| 4Fe-4S ferredoxins | 0.6899 | INHERITED FROM: life span variant || transgene expression increased |
| GST C-terminal domain-like | 0.7031 | INHERITED FROM: organism heat hypersensitive || enzyme activity reduced || cadmium hypersensitive || metal response variant || organism environmental stimulus response variant || organism electrophilic stress hypersensitive || enzyme activity variant || organism stress response variant |
| MIT domain | 0.7586 | INHERITED FROM: protein protein interaction variant || protein aggregation variant || protein interaction variant |
| ADC-like | 0.7586 | INHERITED FROM: protein protein interaction variant || protein aggregation variant || protein interaction variant || metabolic pathway variant || transgene expression reduced || protein metabolism variant |
| alpha/beta-Hydrolases | 0.7645 | INHERITED FROM: acetylcholinesterase reduced || acetylcholinesterase activity variant |
| EF-hand | 0.7661 | INHERITED FROM: gonad sheath contractions variant || aldicarb response variant || protein aggregation variant || protein interaction variant || somatic sheath physiology variant || cellular osmotic stress response variant |
| Clavaminate synthase-like | 0.8138 | INHERITED FROM: life span variant || histone methylation variant || protein methylation variant |
| Ribonuclease H-like | 0.8165 | INHERITED FROM: RNAi enhanced || 21U RNA expression variant || somatic transgene silencing variant || siRNA expression variant || RNAi response variant || maintenance of gene silencing variant || RNA expression variant |
| NAD kinase/diacylglycerol kinase-like | 0.8165 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant |
| Cyclophilin-like | 0.8267 | INHERITED FROM: protein protein interaction variant || transgene subcellular localization variant || protein aggregation variant || protein interaction variant || transgene expression variant || gene expression variant || pattern of transgene expression variant |
| CoA-dependent acyltransferases | 0.8267 | INHERITED FROM: dauer development variant || organism metabolism processing variant |
| UBA-like | 0.838 | INHERITED FROM: protein protein interaction variant || protein aggregation variant |
| SNF-like | 0.8568 | INHERITED FROM: drug hypersensitive |
| Leucine zipper domain | 0.8635 | INHERITED FROM: pore forming toxin response variant || pathogen susceptibility increased || mRNA expression variant || level of transgene expression variant || mRNA levels reduced || transgene expression reduced |
| GTPase activation domain, GAP | 0.8728 | INHERITED FROM: protein expression variant |
| Eukaryotic type KH-domain (KH-domain type I) | 0.8728 | INHERITED FROM: RNA expression variant |
| Thioredoxin-like | 0.9067 | INHERITED FROM: organism heat hypersensitive || enzyme activity reduced || paraquat response variant || organism toxic chemical response variant || metal response variant || organism electrophilic stress hypersensitive || enzyme activity variant || organism stress response variant |
| p53-like transcription factors | 0.9113 | INHERITED FROM: ectopic expression transgene || gene expression level reduced |
| Immunoglobulin | 0.9182 | INHERITED FROM: aldicarb response variant || growth rate variant || protein degradation variant |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.9201 | INHERITED FROM: gene expression level reduced || dauer resistance to harsh conditions variant || gene expression level high || fat content increased || level of transgene expression variant || SDS sensitive dauer || transgene expression reduced |
| Ribonuclease PH domain 2-like | 0.936 | INHERITED FROM: early larval arrest |
| Nucleotide-diphospho-sugar transferases | 0.9403 | INHERITED FROM: lectin response variant || resistant to lectin |
| Saposin | 0.9619 | INHERITED FROM: germ cell resistant ionizing radiation || germ cell ionizing radiation response variant || pathogen load variant || level of transgene expression variant || radiation induced germ cell apoptosis variant || increased pathogen survival || transgene expression reduced |
| PAZ domain | 0.9948 | INHERITED FROM: mRNA levels increased || RNAi enhanced || 21U RNA expression variant || somatic transgene silencing variant || siRNA expression variant || RNAi response variant || maintenance of gene silencing variant || RNA expression variant |
| beta-beta-alpha zinc fingers | 1 | INHERITED FROM: imipramine resistant || inhibitor of serotonin uptake variant || organism metabolism processing variant || egg laying imipramine resistant |
| Ligand-binding domain in the NO signalling and Golgi transport | 1 | INHERITED FROM: anesthetic response variant || carbon dioxide response variant || carbon dioxide avoidance variant || drug response variant || chemical response variant |
| Nuclear receptor ligand-binding domain | 1 | INHERITED FROM: gene expression level reduced || dauer resistance to harsh conditions variant || gene expression level high || fat content increased || level of transgene expression variant || SDS sensitive dauer || transgene expression reduced |
| F-box domain | 1 | INHERITED FROM: resistant to protein aggregation induced paralysis |
| B-box zinc-binding domain | 1 | INHERITED FROM: protein protein interaction variant || transgene subcellular localization variant || protein aggregation variant || protein interaction variant || transgene expression variant || gene expression variant |
| Bet v1-like | 1 | INHERITED FROM: growth rate variant |
| Snake toxin-like | 1 | INHERITED FROM: fat content reduced |
| Family A G protein-coupled receptor-like | 1 | INHERITED FROM: serotonin induced fat reduction variant || male tail curling serotonin variant || serotonin induced pumping variant || locomotion rate serotonin variant |
| RING/U-box | 1 | INHERITED FROM: protein protein interaction variant || germ cell ionizing radiation response variant || transgene subcellular localization variant || germ cell hypersensitive ionizing radiation || organism ionizing radiation response variant || protein aggregation variant || protein interaction variant || cell ionizing radiation response variant || organism metabolism processing variant || gene expression variant || cell stress response variant || pattern of transgene expression variant |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Integrin alpha N-terminal domain | 0 | Direct |
| Cytochrome c | 0 | Direct |
| Class II aaRS ABD-related | 0 | Direct |
| FAD-linked oxidases, C-terminal domain | 0 | Direct |
| JAB1/MPN domain | 0 | Direct |
| BEACH domain | 0 | Direct |
| Ferritin-like | 0 | Direct |
| ACP-like | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| VPS9 domain | 0 | Direct |
| dsRNA-binding domain-like | 0 | Direct |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
| Kringle-like | 0 | Direct |
| MFPT repeat-like | 0 | Direct |
| PEP carboxykinase-like | 0 | Direct |
| ADP-ribosylation | 0 | Direct |
| Families 57/38 glycoside transferase middle domain | 0 | Direct |
| Thyroglobulin type-1 domain | 0 | Direct |
| HSP40/DnaJ peptide-binding domain | 0 | Direct |
| Intermediate filament protein, coiled coil region | 0 | Direct |
| GroEL apical domain-like | 0 | Direct |
| t-snare proteins | 0 | Direct |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
| Glycolipid transfer protein, GLTP | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Translational machinery components | 0 | Direct |
| alpha-catenin/vinculin-like | 0 | Direct |
| TGS-like | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| Tubulin nucleotide-binding domain-like | 0 | Direct |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0 | Direct |
| Nucleoporin domain | 0 | Direct |
| PEBP-like | 0 | Direct |
| L30e-like | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| Purine and uridine phosphorylases | 0 | Direct |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | Direct |
| ARID-like | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| Tim10-like | 0 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| Proton glutamate symport protein | 0 | Direct |
| ArfGap/RecO-like zinc finger | 0 | Direct |
| Band 7/SPFH domain | 0 | Direct |
| Polo-box domain | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| FAD-binding/transporter-associated domain-like | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| Carboxypeptidase regulatory domain-like | 0 | Direct |
| PurM C-terminal domain-like | 0 | Direct |
| LDH C-terminal domain-like | 0 | Direct |
| Composite domain of metallo-dependent hydrolases | 0 | Direct |
| Spectrin repeat | 0 | Direct |
| Class I glutamine amidotransferase-like | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
| CO dehydrogenase ISP C-domain like | 0 | Direct |
| PABC (PABP) domain | 0 | Direct |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
| LysM domain | 0 | Direct |
| Transducin (alpha subunit), insertion domain | 0 | Direct |
| Molybdenum cofactor-binding domain | 0 | Direct |
| Cadherin-like | 0 | Direct |
| Skp1 dimerisation domain-like | 0 | Direct |
| Acyl-CoA dehydrogenase NM domain-like | 0 | Direct |
| Troponin coil-coiled subunits | 0 | Direct |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | Direct |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | Direct |
| LEM domain | 0 | Direct |
| Profilin (actin-binding protein) | 0 | Direct |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
| Chitinase insertion domain | 0 | Direct |
| Small-conductance potassium channel | 0 | Direct |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | Direct |
| Galactose mutarotase-like | 0 | Direct |
| Outer arm dynein light chain 1 | 0 | Direct |
| Tubulin C-terminal domain-like | 0 | Direct |
| HCP-like | 0 | Direct |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | Direct |
| R3H domain | 0 | Direct |
| Subtilisin-like | 0 | Direct |
| beta-lactamase/transpeptidase-like | 0 | Direct |
| cAMP-binding domain-like | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| FF domain | 0 | Direct |
| SCP-like | 0 | Direct |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
| Thiolase-like | 0 | Direct |
| CBD9-like | 0 | Direct |
| Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
| Heme-dependent catalase-like | 0 | Direct |
| HRDC-like | 0 | Direct |
| Cation efflux protein cytoplasmic domain-like | 0 | Direct |
| 2Fe-2S ferredoxin-like | 0 | Direct |
| Tubby C-terminal domain-like | 0 | Direct |
| Surp module (SWAP domain) | 0 | Direct |
| Citrate synthase | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| PK beta-barrel domain-like | 0 | Direct |
| SIS domain | 0 | Direct |
| Aquaporin-like | 0 | Direct |
| YbiA-like | 0 | Direct |
| Protease propeptides/inhibitors | 0 | Direct |
| PGBD-like | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| PAP/OAS1 substrate-binding domain | 0 | Direct |
| lambda repressor-like DNA-binding domains | 0 | Direct |
| GAS2 domain-like | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Acetyl-CoA synthetase-like | 0 | Direct |
| Invertebrate chitin-binding proteins | 0 | Direct |
| Rap/Ran-GAP | 0 | Direct |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
| YWTD domain | 0 | Direct |
| RBP11-like subunits of RNA polymerase | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| MOSC N-terminal domain-like | 0 | Direct |
| Glutathione synthetase ATP-binding domain-like | 0 | Direct |
| Ribosomal L27 protein-like | 0 | Direct |
| Zn-binding ribosomal proteins | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Sec7 domain | 0 | Direct |
| Ribosomal proteins S24e, L23 and L15e | 0 | Direct |
| CAD & PB1 domains | 0 | Direct |
| AN1-like Zinc finger | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Doublecortin (DC) | 0 | Direct |
| Ribosomal protein L1 | 0 | Direct |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | Direct |
| SAICAR synthase-like | 0 | Direct |
| Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
| Ribosomal protein S10 | 0 | Direct |
| GroEL equatorial domain-like | 0 | Direct |
| PurM N-terminal domain-like | 0 | Direct |
| Activating enzymes of the ubiquitin-like proteins | 0 | Direct |
| WGR domain-like | 0 | Direct |
| Ribosomal protein S18 | 0 | Direct |
| L-aspartase-like | 0 | Direct |
| Annexin | 0 | Direct |
| Phoshotransferase/anion transport protein | 0 | Direct |
| Galactose oxidase, central domain | 0 | Direct |
| alpha/beta knot | 0 | Direct |
| MgtE membrane domain-like | 0 | Direct |
| PIN domain-like | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
| Retrovirus zinc finger-like domains | 0 | Direct |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | Direct |
| Elafin-like | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| Integrin domains | 0 | Direct |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
| ISP domain | 0 | Direct |
| Nucleoside diphosphate kinase, NDK | 0 | Direct |
| Carbonic anhydrase | 0 | Direct |
| Chromo domain-like | 0 | Direct |
| NagB/RpiA/CoA transferase-like | 0 | Direct |
| S-adenosylmethionine synthetase | 0 | Direct |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | Direct |
| Radical SAM enzymes | 0 | Direct |
| Molybdenum cofactor biosynthesis proteins | 0 | Direct |
| TK C-terminal domain-like | 0 | Direct |
| Mitochondrial carrier | 0 | Direct |
| Cystatin/monellin | 0 | Direct |
| Fibrinogen C-terminal domain-like | 0 | Direct |
| Creatinase/prolidase N-terminal domain | 0 | Direct |
| Terpenoid synthases | 0 | Direct |
| CRAL/TRIO N-terminal domain | 0 | Direct |
| GAT-like domain | 0 | Direct |
| Cdc48 domain 2-like | 0 | Direct |
| GYF domain | 0 | Direct |
| Blood coagulation inhibitor (disintegrin) | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
| Cullin repeat-like | 0 | Direct |
| Oxysterol-binding protein-like | 0 | Direct |
| PUA domain-like | 0 | Direct |
| Nop domain | 0 | Direct |
| PLC-like phosphodiesterases | 0 | Direct |
| Hormone receptor domain | 0 | Direct |
| Sec63 N-terminal domain-like | 0 | Direct |
| Histone-fold | 0 | Direct |
| eIF4e-like | 0 | Direct |
| SAND domain-like | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| Hedgehog/intein (Hint) domain | 0 | Direct |
| MIR domain | 0 | Direct |
| DNA repair protein MutS, domain III | 0 | Direct |
| SPOC domain-like | 0 | Direct |
| Putative DNA-binding domain | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| Complement control module/SCR domain | 0 | Direct |
| PHM/PNGase F | 0 | Direct |
| Pepsin inhibitor-3 | 0 | Direct |
| Actin-like ATPase domain | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Rudiment single hybrid motif | 0 | Direct |
| WWE domain | 0 | Direct |
| Single hybrid motif | 0 | Direct |
| GroEL-intermediate domain like | 0 | Direct |
| Carbohydrate phosphatase | 0 | Direct |
| Aldolase | 0 | Direct |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
| PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | Direct |
| Ribokinase-like | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| Pentein | 0 | Direct |
| ThrRS/AlaRS common domain | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| Clc chloride channel | 0 | Direct |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
| DEATH domain | 0 | Direct |
| GroES-like | 0 | Direct |
| Periplasmic binding protein-like II | 0 | Direct |
| Arginase/deacetylase | 0 | Direct |
| Restriction endonuclease-like | 0 | Direct |
| Heme-dependent peroxidases | 0 | Direct |
| Carbon-nitrogen hydrolase | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| Second domain of FERM | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| PreATP-grasp domain | 0 | Direct |
| ENTH/VHS domain | 0 | Direct |
| Chaperone J-domain | 0 | Direct |
| Diaminopimelate epimerase-like | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Ran binding protein zinc finger-like | 0 | Direct |
| Insulin-like | 0 | Direct |
| Ribosomal protein L10-like | 0 | Direct |
| Hypothetical protein c14orf129, hspc210 | 0 | Direct |
| Bacterial exopeptidase dimerisation domain | 0 | Direct |
| PYP-like sensor domain (PAS domain) | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| Nucleotidyltransferase | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| HSP20-like chaperones | 0 | Direct |
| ALDH-like | 0 | Direct |
| FtsH protease domain-like | 0 | Direct |
| Tricorn protease domain 2 | 0 | Direct |
| P-loop containing nucleoside triphosphate hydrolases | 0.0000004141 | Direct |
| PH domain-like | 0.00002159 | Direct |
| PapD-like | 0.009043 | Inherited |
| PDZ domain-like | 0.009221 | Inherited |
| TPR-like | 0.01305 | Inherited |
| Periplasmic binding protein-like I | 0.01452 | Inherited |
| ABC transporter transmembrane region | 0.02042 | Inherited |
| ARM repeat | 0.02104 | Inherited |
| Protein kinase-like (PK-like) | 0.03839 | Inherited |
| Nucleic acid-binding proteins | 0.04851 | Inherited |
| SH3-domain | 0.04851 | Inherited |
| Homeodomain-like | 0.05532 | Inherited |
| WD40 repeat-like | 0.06563 | Inherited |
| CCCH zinc finger | 0.07001 | Inherited |
| FYVE/PHD zinc finger | 0.07992 | Inherited |
| Translation proteins | 0.08703 | Inherited |
| "Winged helix" DNA-binding domain | 0.09848 | Inherited |
| Nucleotide cyclase | 0.1021 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.1021 | Inherited |
| SMAD/FHA domain | 0.1083 | Inherited |
| Calcium ATPase, transmembrane domain M | 0.1208 | Inherited |
| Regulator of G-protein signaling, RGS | 0.1347 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1347 | Inherited |
| EGF/Laminin | 0.1403 | Inherited |
| Acid proteases | 0.1498 | Inherited |
| Calcium ATPase, transduction domain A | 0.1498 | Inherited |
| Cysteine-rich domain | 0.1588 | Inherited |
| Quinoprotein alcohol dehydrogenase-like | 0.1669 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.1728 | Inherited |
| HMG-box | 0.1857 | Inherited |
| DBL homology domain (DH-domain) | 0.1857 | Inherited |
| ClpP/crotonase | 0.1857 | Inherited |
| Cytochrome P450 | 0.1886 | Inherited |
| (Trans)glycosidases | 0.1994 | Inherited |
| Ankyrin repeat | 0.2154 | Inherited |
| Cyclin-like | 0.2409 | Inherited |
| Cysteine proteinases | 0.2516 | Inherited |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.2544 | Inherited |
| Bromodomain | 0.2544 | Inherited |
| Tudor/PWWP/MBT | 0.2544 | Inherited |
| POZ domain | 0.2728 | Inherited |
| SNARE-like | 0.2824 | Inherited |
| Lipocalins | 0.2826 | Inherited |
| Metallo-dependent phosphatases | 0.2883 | Inherited |
| RNA-binding domain, RBD | 0.3043 | Inherited |
| DNA/RNA polymerases | 0.3134 | Inherited |
| Cation efflux protein transmembrane domain-like | 0.3469 | Inherited |
| PX domain | 0.3469 | Inherited |
| Translation proteins SH3-like domain | 0.3469 | Inherited |
| HAD-like | 0.3705 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.3863 | Inherited |
| PLP-dependent transferases | 0.3926 | Inherited |
| Ubiquitin-like | 0.4027 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.4229 | Inherited |
| HD-domain/PDEase-like | 0.4236 | Inherited |
| FKBP-like | 0.4236 | Inherited |
| RNI-like | 0.4258 | Inherited |
| Class II aaRS and biotin synthetases | 0.4413 | Inherited |
| Hect, E3 ligase catalytic domain | 0.4686 | Inherited |
| DHS-like NAD/FAD-binding domain | 0.4686 | Inherited |
| Myosin rod fragments | 0.4686 | Inherited |
| PRTase-like | 0.4686 | Inherited |
| Ribosomal protein S5 domain 2-like | 0.5025 | Inherited |
| Galactose-binding domain-like | 0.5025 | Inherited |
| Sm-like ribonucleoproteins | 0.5054 | Inherited |
| Cystine-knot cytokines | 0.5054 | Inherited |
| SH2 domain | 0.5147 | Inherited |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.5152 | Inherited |
| Calpain large subunit, middle domain (domain III) | 0.5152 | Inherited |
| Riboflavin synthase domain-like | 0.5152 | Inherited |
| FAD/NAD(P)-binding domain | 0.5317 | Inherited |
| WW domain | 0.5418 | Inherited |
| FAD-linked reductases, C-terminal domain | 0.5418 | Inherited |
| Voltage-gated potassium channels | 0.5497 | Inherited |
| Nucleotidylyl transferase | 0.5508 | Inherited |
| SAM/Pointed domain | 0.5508 | Inherited |
| UBC-like | 0.5542 | Inherited |
| SET domain | 0.5542 | Inherited |
| Seven-hairpin glycosidases | 0.57 | Inherited |
| Multidrug resistance efflux transporter EmrE | 0.577 | Inherited |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.6146 | Inherited |
| Di-copper centre-containing domain | 0.6253 | Inherited |
| KA1-like | 0.6253 | Inherited |
| Nucleotide-binding domain | 0.6253 | Inherited |
| HIT/MYND zinc finger-like | 0.6534 | Inherited |
| S-adenosyl-L-methionine-dependent methyltransferases | 0.6626 | Inherited |
| MFS general substrate transporter | 0.6635 | Inherited |
| Frizzled cysteine-rich domain | 0.6899 | Inherited |
| S15/NS1 RNA-binding domain | 0.6899 | Inherited |
| 4Fe-4S ferredoxins | 0.6899 | Inherited |
| GST C-terminal domain-like | 0.7031 | Inherited |
| MIT domain | 0.7586 | Inherited |
| ADC-like | 0.7586 | Inherited |
| alpha/beta-Hydrolases | 0.7645 | Inherited |
| EF-hand | 0.7661 | Inherited |
| Clavaminate synthase-like | 0.8138 | Inherited |
| Ribonuclease H-like | 0.8165 | Inherited |
| NAD kinase/diacylglycerol kinase-like | 0.8165 | Inherited |
| Cyclophilin-like | 0.8267 | Inherited |
| CoA-dependent acyltransferases | 0.8267 | Inherited |
| UBA-like | 0.838 | Inherited |
| SNF-like | 0.8568 | Inherited |
| Leucine zipper domain | 0.8635 | Inherited |
| GTPase activation domain, GAP | 0.8728 | Inherited |
| Eukaryotic type KH-domain (KH-domain type I) | 0.8728 | Inherited |
| Thioredoxin-like | 0.9067 | Inherited |
| p53-like transcription factors | 0.9113 | Inherited |
| Immunoglobulin | 0.9182 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.9201 | Inherited |
| Ribonuclease PH domain 2-like | 0.936 | Inherited |
| Nucleotide-diphospho-sugar transferases | 0.9403 | Inherited |
| Saposin | 0.9619 | Inherited |
| PAZ domain | 0.9948 | Inherited |
| beta-beta-alpha zinc fingers | 1 | Inherited |
| Ligand-binding domain in the NO signalling and Golgi transport | 1 | Inherited |
| Nuclear receptor ligand-binding domain | 1 | Inherited |
| F-box domain | 1 | Inherited |
| B-box zinc-binding domain | 1 | Inherited |
| Bet v1-like | 1 | Inherited |
| Snake toxin-like | 1 | Inherited |
| Family A G protein-coupled receptor-like | 1 | Inherited |
| RING/U-box | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| HSP90 C-terminal domain | 0 | DIRECT |
| NOL1/NOP2/sun | 0 | DIRECT |
| WWE domain | 0 | DIRECT |
| LEM domain | 0 | DIRECT |
| Sir2 family of transcriptional regulators | 0 | DIRECT |
| GABA-aminotransferase-like | 0 | DIRECT |
| 5' to 3' exonuclease catalytic domain | 0 | DIRECT |
| PurM N-terminal domain-like | 0 | DIRECT |
| Cullin repeat | 0 | DIRECT |
| RecA protein-like (ATPase-domain) | 0 | DIRECT |
| Glycogenin | 0 | DIRECT |
| DNA gyrase/MutL, N-terminal domain | 0 | DIRECT |
| Sec63 C-terminal domain-like | 0 | DIRECT |
| Adenosine/AMP deaminase | 0 | DIRECT |
| CoA-binding domain | 0 | DIRECT |
| Class II glutamine amidotransferases | 0 | DIRECT |
| Ribosomal protein S10 | 0 | DIRECT |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0 | DIRECT |
| Skp1 dimerisation domain-like | 0 | DIRECT |
| Second domain of FERM | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| Translational machinery components | 0 | DIRECT |
| Clathrin adaptor core protein | 0 | DIRECT |
| Acylamino-acid-releasing enzyme, C-terminal donain | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| Sec7 domain | 0 | DIRECT |
| DPP6 catalytic domain-like | 0 | DIRECT |
| Aminoacid dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Pancreatic carboxypeptidases | 0 | DIRECT |
| PDI-like | 0 | DIRECT |
| Tim10/DDP | 0 | DIRECT |
| Fatty acid binding protein-like | 0 | DIRECT |
| Pepsin inhibitor-3 | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| Actin/HSP70 | 0 | DIRECT |
| Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
| BEACH domain | 0 | DIRECT |
| L-aminoacid/polyamine oxidase | 0 | DIRECT |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | DIRECT |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
| a tRNA synthase domain | 0 | DIRECT |
| RNA-polymerase beta-prime | 0 | DIRECT |
| Mitochondrial carrier | 0 | DIRECT |
| AMPK-beta glycogen binding domain-like | 0 | DIRECT |
| Intermediate filament protein, coiled coil region | 0 | DIRECT |
| Arylsulfatase | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| D-aminoacid oxidase, N-terminal domain | 0 | DIRECT |
| Formate/glycerate dehydrogenases, NAD-domain | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| DPP6 N-terminal domain-like | 0 | DIRECT |
| Regulator of G-protein signaling, RGS | 0 | DIRECT |
| Band 7/SPFH domain | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | DIRECT |
| Acireductone dioxygenase | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | DIRECT |
| HCDH C-domain-like | 0 | DIRECT |
| XPF/Rad1/Mus81 nuclease | 0 | DIRECT |
| CO dehydrogenase ISP C-domain like | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| COMT-like | 0 | DIRECT |
| Ribokinase-like | 0 | DIRECT |
| Gamma-glutamyltranspeptidase-like | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| Ribosomal protein L18 and S11 | 0 | DIRECT |
| HEAT repeat | 0 | DIRECT |
| La domain | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | DIRECT |
| 1,3-glucuronyltransferase | 0 | DIRECT |
| GYF domain | 0 | DIRECT |
| beta 1,4 galactosyltransferase (b4GalT1) | 0 | DIRECT |
| VHS domain | 0 | DIRECT |
| Small-conductance potassium channel | 0 | DIRECT |
| PhzC/PhzF-like | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| Cadherin | 0 | DIRECT |
| Elafin-like | 0 | DIRECT |
| Vertebrate phospholipase A2 | 0 | DIRECT |
| Ran binding protein zinc finger-like | 0 | DIRECT |
| Calcium ATPase, transmembrane domain M | 0 | DIRECT |
| Anticodon-binding domain of Class II aaRS | 0 | DIRECT |
| Protein prenyltransferases | 0 | DIRECT |
| PaaI/YdiI-like | 0 | DIRECT |
| Alcohol dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | DIRECT |
| Hedgehog C-terminal (Hog) autoprocessing domain | 0 | DIRECT |
| CoA transferase alpha subunit-like | 0 | DIRECT |
| 28-residue LRR | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Clathrin coat assembly domain | 0 | DIRECT |
| Ubiquitin activating enzymes (UBA) | 0 | DIRECT |
| MOSC N-terminal domain-like | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| Tubulin, C-terminal domain | 0 | DIRECT |
| FtsH protease domain-like | 0 | DIRECT |
| SAM (sterile alpha motif) domain | 0 | DIRECT |
| Arginine methyltransferase | 0 | DIRECT |
| RNA editing terminal uridyl transferase 2, RET2, domain 2 | 0 | DIRECT |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| beta-Lactamase/D-ala carboxypeptidase | 0 | DIRECT |
| Profilin (actin-binding protein) | 0 | DIRECT |
| Fibrinogen C-terminal domain-like | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| Glycerol kinase | 0 | DIRECT |
| YicI catalytic domain-like | 0 | DIRECT |
| Carboxypeptidase regulatory domain | 0 | DIRECT |
| Surp module (SWAP domain) | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | DIRECT |
| LysM domain | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain | 0 | DIRECT |
| FHA domain | 0 | DIRECT |
| Armadillo repeat | 0 | DIRECT |
| acyl-CoA oxidase C-terminal domains | 0 | DIRECT |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | DIRECT |
| Molybdenum cofactor-binding domain | 0 | DIRECT |
| Insulin-like | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | DIRECT |
| Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
| Amylase, catalytic domain | 0 | DIRECT |
| Mammalian PLC | 0 | DIRECT |
| TBP-associated factors, TAFs | 0 | DIRECT |
| Phosphatidylethanolamine binding protein | 0 | DIRECT |
| alpha-mannosidase | 0 | DIRECT |
| Internalin LRR domain | 0 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | DIRECT |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | DIRECT |
| BC C-terminal domain-like | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
| Ribosomal protein L1 | 0 | DIRECT |
| Nucleosome core histones | 0 | DIRECT |
| Poly(A) polymerase, PAP, N-terminal domain | 0 | DIRECT |
| Class I glutamine amidotransferases (GAT) | 0 | DIRECT |
| Chitinase insertion domain | 0 | DIRECT |
| Class I aldolase | 0 | DIRECT |
| YihX-like | 0 | DIRECT |
| Poly(A) polymerase, PAP, middle domain | 0 | DIRECT |
| Ngr ectodomain-like | 0 | DIRECT |
| HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
| Complement control module/SCR domain | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| Phosphate binding protein-like | 0 | DIRECT |
| Chromo domain | 0 | DIRECT |
| Clc chloride channel | 0 | DIRECT |
| Reductases | 0 | DIRECT |
| Acetyl-CoA synthetase-like | 0 | DIRECT |
| Methionine aminopeptidase, insert domain | 0 | DIRECT |
| Pancreatic carboxypeptidase, activation domain | 0 | DIRECT |
| Pumilio repeat | 0 | DIRECT |
| Glycolipid transfer protein, GLTP | 0 | DIRECT |
| POU-specific domain | 0 | DIRECT |
| Thyroglobulin type-1 domain | 0 | DIRECT |
| alpha-Amylases, C-terminal beta-sheet domain | 0 | DIRECT |
| Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| BAR domain | 0 | DIRECT |
| Trunk domain of Sec23/24 | 0 | DIRECT |
| DNA gyrase/MutL, second domain | 0 | DIRECT |
| CAT-like | 0 | DIRECT |
| Ras-binding domain, RBD | 0 | DIRECT |
| Dual specificity phosphatase-like | 0 | DIRECT |
| PLC-like (P variant) | 0 | DIRECT |
| t-snare proteins | 0 | DIRECT |
| NLI interacting factor-like phosphatase | 0 | DIRECT |
| L30e/L7ae ribosomal proteins | 0 | DIRECT |
| Cell cycle control phosphatase, catalytic domain | 0 | DIRECT |
| Inositol polyphosphate kinase (IPK) | 0 | DIRECT |
| ARID domain | 0 | DIRECT |
| D-aminoacid oxidase-like | 0 | DIRECT |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0 | DIRECT |
| SAND domain | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| Nucleoside diphosphate kinase, NDK | 0 | DIRECT |
| Filamin repeat (rod domain) | 0 | DIRECT |
| Peptidylglycine alpha-hydroxylating monooxygenase, PHM | 0 | DIRECT |
| NTF2-like | 0 | DIRECT |
| Cofilin-like | 0 | DIRECT |
| Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
| Purine and uridine phosphorylases | 0 | DIRECT |
| Hormone receptor domain | 0 | DIRECT |
| Matrix metalloproteases, catalytic domain | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| PUA domain | 0 | DIRECT |
| Double-stranded RNA-binding domain (dsRBD) | 0 | DIRECT |
| Translation initiation factor eIF4e | 0 | DIRECT |
| Alcohol dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
| MFPT repeat | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
| PDZ domain | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| MIF4G domain-like | 0 | DIRECT |
| Pleckstrin-homology domain (PH domain) | 0 | DIRECT |
| p120GAP domain-like | 0 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | DIRECT |
| LacY-like proton/sugar symporter | 0 | DIRECT |
| Sec63 N-terminal domain | 0 | DIRECT |
| Cytoplasmic domain of inward rectifier potassium channel | 0 | DIRECT |
| Doublecortin (DC) | 0 | DIRECT |
| BC ATP-binding domain-like | 0 | DIRECT |
| Biotinyl/lipoyl-carrier proteins and domains | 0 | DIRECT |
| Ribosomal protein S18 | 0 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| DNA repair protein MutS, domain III | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
| Carbonic anhydrase | 0 | DIRECT |
| PDEase | 0 | DIRECT |
| Paired domain | 0 | DIRECT |
| Third domain of FERM | 0 | DIRECT |
| UDP-glucose pyrophosphorylase | 0 | DIRECT |
| Chaperone J-domain | 0 | DIRECT |
| RNA-polymerase beta | 0 | DIRECT |
| Proprotein convertase P-domain | 0 | DIRECT |
| Spectrin repeat | 0 | DIRECT |
| PABC (PABP) domain | 0 | DIRECT |
| Epoxide hydrolase | 0 | DIRECT |
| Quinoprotein alcohol dehydrogenase-like | 0 | DIRECT |
| Poly(ADP-ribose) polymerase, C-terminal domain | 0 | DIRECT |
| GAS2 domain | 0 | DIRECT |
| Histone deacetylase, HDAC | 0 | DIRECT |
| LDH N-terminal domain-like | 0 | DIRECT |
| Eps15 homology domain (EH domain) | 0 | DIRECT |
| Tubulin, GTPase domain | 0 | DIRECT |
| HAT/Suf repeat | 0 | DIRECT |
| BC N-terminal domain-like | 0 | DIRECT |
| YWTD domain | 0 | DIRECT |
| Aquaporin-like | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| SWIRM domain | 0 | DIRECT |
| Anticodon-binding domain | 0 | DIRECT |
| First domain of FERM | 0 | DIRECT |
| Troponin I | 0 | DIRECT |
| WGR domain | 0 | DIRECT |
| Laminin G-like module | 0 | DIRECT |
| Acyl-carrier protein (ACP) | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), catalytic domain | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
| alpha-mannosidase, domain 2 | 0 | DIRECT |
| PurM C-terminal domain-like | 0 | DIRECT |
| Heme-dependent catalases | 0 | DIRECT |
| Retrovirus zinc finger-like domains | 0 | DIRECT |
| Arfaptin, Rac-binding fragment | 0 | DIRECT |
| Acyl-CoA thioesterase | 0 | DIRECT |
| RhoGDI-like | 0 | DIRECT |
| CUT domain | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| Phosphotyrosine-binding domain (PTB) | 0 | DIRECT |
| SCF ubiquitin ligase complex WHB domain | 0 | DIRECT |
| MutT-like | 0 | DIRECT |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | DIRECT |
| Sterol carrier protein, SCP | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Annexin | 0 | DIRECT |
| Rap/Ran-GAP | 0 | DIRECT |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | DIRECT |
| Polo-box duplicated region | 0 | DIRECT |
| Choline kinase | 0 | DIRECT |
| U-box | 0 | DIRECT |
| ets domain | 0 | DIRECT |
| Lactate & malate dehydrogenases, C-terminal domain | 0 | DIRECT |
| Myeloperoxidase-like | 0 | DIRECT |
| YbiA-like | 0 | DIRECT |
| Calpain large subunit, catalytic domain (domain II) | 0 | DIRECT |
| Hsp90 middle domain | 0 | DIRECT |
| DEATH domain, DD | 0 | DIRECT |
| alpha-mannosidase, C-terminal domain | 0 | DIRECT |
| SMAD domain | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| Hydantoinase (dihydropyrimidinase), catalytic domain | 0 | DIRECT |
| NHL repeat | 0 | DIRECT |
| Glycosyl transferases group 1 | 0 | DIRECT |
| Poly(A) polymerase, PAP, C-terminal domain | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| Phosphoribosyltransferases (PRTases) | 0 | DIRECT |
| UBA domain | 0 | DIRECT |
| DEP domain | 0 | DIRECT |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | DIRECT |
| CO dehydrogenase flavoprotein N-terminal domain-like | 0 | DIRECT |
| Brix domain | 0 | DIRECT |
| Glutaminase | 0 | DIRECT |
| HSP20 | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| S-adenosylmethionine synthetase | 0 | DIRECT |
| ATP-dependent protease Lon (La), catalytic domain | 0 | DIRECT |
| cAMP-binding domain | 0 | DIRECT |
| Pyk2-associated protein beta ARF-GAP domain | 0 | DIRECT |
| Subtilases | 0 | DIRECT |
| Inositol monophosphatase/fructose-1,6-bisphosphatase-like | 0 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0 | DIRECT |
| Biotin dependent carboxylase carboxyltransferase domain | 0 | DIRECT |
| AN1-like Zinc finger | 0 | DIRECT |
| Adenain-like | 0 | DIRECT |
| alpha-catenin/vinculin | 0 | DIRECT |
| Hexokinase | 0 | DIRECT |
| Hydantoinase (dihydropyrimidinase) | 0 | DIRECT |
| Hypothetical protein c14orf129, hspc210 | 0 | DIRECT |
| Reprolysin-like | 0 | DIRECT |
| Myotubularin-like phosphatases | 0 | DIRECT |
| Regulator of chromosome condensation RCC1 | 0 | DIRECT |
| Ferredoxin reductase FAD-binding domain-like | 0 | DIRECT |
| Linker histone H1/H5 | 0 | DIRECT |
| CRAL/TRIO N-terminal domain | 0 | DIRECT |
| IF2B-like | 0 | DIRECT |
| Citrate synthase | 0 | DIRECT |
| Cdc48 domain 2-like | 0 | DIRECT |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
| Tetraspanin | 0 | DIRECT |
| GAPDH-like | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| PEP carboxykinase C-terminal domain | 0 | DIRECT |
| Type II chitinase | 0 | DIRECT |
| Bactericidal permeability-increasing protein, BPI | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| Erythroid transcription factor GATA-1 | 0 | DIRECT |
| Proteasome subunits | 0 | DIRECT |
| Glycerophosphoryl diester phosphodiesterase | 0 | DIRECT |
| acyl-CoA oxidase N-terminal domains | 0 | DIRECT |
| Single strand DNA-binding domain, SSB | 0 | DIRECT |
| Thiolase-related | 0 | DIRECT |
| HD domain | 0 | DIRECT |
| Oxysterol-binding protein | 0 | DIRECT |
| Tandem AAA-ATPase domain | 0.003654 | INHERITED FROM: germline RNAi resistant || organism UV response variant || RNAi response variant || cell stress response variant || sick || organism stress response variant |
| ABC transporter ATPase domain-like | 0.01003 | INHERITED FROM: cadmium response variant || RNAi resistant || RNAi response variant || cadmium hypersensitive || chemical hypersensitive || metal response variant || colchicine hypersensitive |
| MSP-like | 0.02384 | INHERITED FROM: dauer metabolism variant || dauer lifespan extended || dauer lifespan variant || fat content variant || lipid metabolism variant |
| Homeodomain | 0.03701 | INHERITED FROM: ectopic expression transgene || anesthetic response variant || level of transgene expression variant || carbon dioxide response variant || carbon dioxide avoidance variant || organism metabolism processing variant |
| ABC transporter transmembrane region | 0.04247 | INHERITED FROM: cadmium response variant || RNAi resistant || RNAi response variant || cadmium hypersensitive || chemical hypersensitive || metal response variant || colchicine hypersensitive |
| WD40-repeat | 0.04718 | INHERITED FROM: ivermectin resistant || protein aggregation induced behavior variant || dauer defective || osmotic avoidance variant || pathogen induced antimicrobial gene expression variant || ivermectin response variant |
| G proteins | 0.04739 | INHERITED FROM: sexually dimorphic physiology variant || aldicarb response variant || protein subcellular localization variant || anesthetic response variant || osmotic integrity variant || chemosensory response variant || pathogen release variant || drug induced gene expression variant || chemotaxis variant || cellular osmotic stress response variant || protein phosphorylation variant || carbon dioxide avoidance variant || drug response variant || fat content variant || organism metabolism processing variant || organism environmental stimulus response variant || hermaphrodite physiology variant || protein metabolism variant |
| L-arabinose binding protein-like | 0.05747 | INHERITED FROM: alkaline pH chemotaxis variant || iodide chemotaxis defective || iodide chemotaxis variant || anion positive chemotaxis defective || cation positive chemotaxis variant || cation positive chemotaxis defective || chemosensory response variant || magnesium chemotaxis defective || anion positive chemotaxis variant || aqueous positive chemotaxis variant || chemotaxis variant || lithium chemotaxis defective || thermosensory behavior variant || bromide chemotaxis defective || thermotaxis variant || organism environmental stimulus response variant || organism temperature response variant || bromide chemotaxis variant |
| Protein kinases, catalytic subunit | 0.06104 | INHERITED FROM: second messenger mediated signaling variant || alkaline pH chemotaxis variant || aldicarb response variant || protein subcellular localization variant || copper hypersensitive || kinase activity reduced || drug induced gene expression variant || mechanosensation variant || conflicting sensory integration variant || protein phosphorylation reduced || anoxia response variant || dauer development variant || protein modification variant || lipid synthesis increased || protein phosphorylation variant || protein expression variant || anoxia resistant || metal response variant || egg laying response to food variant || oxygen response variant || chemical response variant || hypoxia response variant || octanol chemotaxis defective || positive chemotaxis variant || colchicine resistant || transgene expression reduced |
| SH3-domain | 0.07439 | INHERITED FROM: protein expression reduced || aldicarb response variant || protein expression variant |
| CCCH zinc finger | 0.08576 | INHERITED FROM: ectopic expression transgene || transgene expression variant || gene expression variant || mRNA expression ectopic |
| Canonical RBD | 0.1018 | INHERITED FROM: starvation induced apoptosis variant || late larval arrest || RNA processing variant || no induction of antimicrobial peptide expression after infection || mRNA export variant || pathogen induced antimicrobial gene expression variant || organism metabolism processing variant || innate immune response variant || sick || RNA metabolism variant || RNA expression variant |
| Extended AAA-ATPase domain | 0.1044 | INHERITED FROM: protein expression increased || spontaneous mutation rate increased || response to bacteria variant || sick |
| Tetratricopeptide repeat (TPR) | 0.1133 | INHERITED FROM: organism metabolism processing variant |
| Cold shock DNA-binding domain-like | 0.1277 | INHERITED FROM: mRNA surveillance defective || nonsense mRNA accumulation || sick || hermaphrodite physiology variant || RNA metabolism variant |
| Motor proteins | 0.1328 | INHERITED FROM: sexually dimorphic mechanosensation variant || male response to hermaphrodite variant |
| Adenylyl and guanylyl cyclase catalytic domain | 0.1328 | INHERITED FROM: second messenger mediated signaling variant || alkaline pH chemotaxis variant || iodide chemotaxis defective || iodide chemotaxis variant || AWC odorant chemotaxis variant || anion positive chemotaxis defective || anesthetic response variant || cation positive chemotaxis variant || cation positive chemotaxis defective || chemosensory response variant || magnesium chemotaxis defective || diacetyl chemotaxis variant || aqueous chemosensory response variant || chemotaxis variant || carbon dioxide response variant || lithium chemotaxis defective || AWC odorant chemotaxis defective || bromide chemotaxis defective || osmotic avoidance variant || organism environmental stimulus response variant || chemical response variant || positive chemotaxis variant || bromide chemotaxis variant |
| HLH, helix-loop-helix DNA-binding domain | 0.1328 | INHERITED FROM: ectopic expression transgene || gene expression level reduced || lysine chemotaxis defective || pathogen resistance increased || aqueous positive chemotaxis defective || fungal resistance increased || RNA expression variant |
| Calcium ATPase, transduction domain A | 0.1719 | INHERITED FROM: nicotine hypersensitive || drug hypersensitive |
| Cyclin | 0.2094 | INHERITED FROM: level of transgene expression variant |
| DBL homology domain (DH-domain) | 0.2094 | INHERITED FROM: aldicarb response variant || pathogen resistance increased || bacterially unswollen || organism environmental stimulus response variant || response to bacteria variant || organism pathogen response variant |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.2094 | INHERITED FROM: receptor mediated endocytosis defective || paraquat resistant || paraquat response variant || transgene expression increased || hypoxia resistant || organism toxic chemical response variant || avoids bacterial lawn || gene expression variant || organism environmental stimulus response variant || oxygen response variant || response to bacteria variant || hypoxia response variant |
| Elongation factors | 0.2094 | INHERITED FROM: protein protein interaction variant || proteasome core activity variant || mRNA levels increased || protein phosphorylation increased || protein aggregation variant || mRNA levels reduced || protein phosphorylation variant |
| HMG-box | 0.2094 | INHERITED FROM: anesthetic response variant || maintenance of gene silencing variant |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.2094 | INHERITED FROM: sexually dimorphic physiology variant || receptor mediated endocytosis defective || transgene expression variant || oocyte physiology variant || hypoxia resistant || avoids bacterial lawn || organism metabolism processing variant || gene expression variant || organism environmental stimulus response variant || oxygen response variant || response to bacteria variant || hypoxia response variant || hermaphrodite physiology variant |
| Histone lysine methyltransferases | 0.2306 | INHERITED FROM: life span variant || ectopic expression antibody || shortened life span || mRNA expression variant || histone methylation variant || RNAi response variant || protein modification variant || metabolic pathway variant || organism metabolism processing variant || gene expression variant || pattern of transgene expression variant || maintenance of gene silencing variant || protein metabolism variant || protein methylation variant |
| Pepsin-like | 0.2306 | INHERITED FROM: protein protein interaction variant || transgene subcellular localization variant || hypoosmotic shock hypersensitive || osmotic integrity variant || protein aggregation variant || protein interaction variant || transgene expression variant || organism metabolism processing variant || gene expression variant || pattern of transgene expression variant |
| Forkhead DNA-binding domain | 0.2539 | INHERITED FROM: transgene subcellular localization variant || transgene expression variant || organism metabolism processing variant || gene expression variant || pattern of transgene expression variant |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.2539 | INHERITED FROM: nicotine hypersensitive || drug hypersensitive || organism environmental stimulus response variant |
| DnaQ-like 3'-5' exonuclease | 0.2539 | INHERITED FROM: RNAi response variant |
| Multidrug efflux transporter AcrB transmembrane domain | 0.2651 | INHERITED FROM: embryo osmotic integrity defective early emb || chemotaxis variant || odorant chemosensory response variant || odorant positive chemotaxis defective || egg integrity defective early emb || positive chemotaxis defective |
| Cytochrome P450 | 0.2724 | INHERITED FROM: cadmium response variant || cadmium hypersensitive || metal response variant || metabolite content decreased |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 0.2793 | INHERITED FROM: fat content variant || lipid metabolism variant |
| Bromodomain | 0.2793 | INHERITED FROM: organism UV hypersensitive || anesthetic response variant || ethanol resistant || drug adaptation variant || acute functional tolerance to alcohol defective || organism UV response variant || gene expression variant || sick || anesthetic resistant |
| Acetylcholinesterase-like | 0.2898 | INHERITED FROM: acetylcholinesterase reduced || enzyme activity reduced || acetylcholinesterase activity variant || enzyme activity variant |
| FAD/NAD-linked reductases, N-terminal and central domains | 0.3079 | INHERITED FROM: organism oxidative stress response variant || pesticide response variant || paraquat response variant || organism toxic chemical response variant |
| Ankyrin repeat | 0.3262 | INHERITED FROM: organism heat response variant || odorant negative chemotaxis defective || octanol chemotaxis variant || octanol chemotaxis defective |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.3262 | INHERITED FROM: AWC odorant chemotaxis variant || hypoosmotic shock hypersensitive || benzaldehyde chemotaxis variant || chemical resistant || chemosensory response variant || antihelmintic response variant || mechanosensation variant || nicotine resistant || sodium chloride chemotaxis variant || thermosensory behavior variant || DMPP resistant || DMPP response variant || drug response variant || thermotaxis variant || selenium response variant || slowing response on food variant || cholinergic agonist resistant || organism environmental stimulus response variant || chemical response variant || positive chemotaxis variant |
| Crotonase-like | 0.3387 | INHERITED FROM: fat content variant || lipid metabolism variant |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.3387 | INHERITED FROM: life span variant || protein protein interaction variant || sexually dimorphic physiology variant || receptor mediated endocytosis defective || protein subcellular localization variant || protein aggregation variant || pattern protein expression variant || oocyte physiology variant || avoids bacterial lawn || pattern of transgene expression variant || response to bacteria variant || sick || hermaphrodite physiology variant |
| Meta-cation ATPase, catalytic domain P | 0.3387 | INHERITED FROM: nicotine hypersensitive || nicotine response variant || organism environmental stimulus response variant |
| PX domain | 0.3729 | INHERITED FROM: protein subcellular localization variant || protein expression variant |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.4308 | INHERITED FROM: response to injury variant || drug resistant || aldicarb response variant || protein subcellular localization variant || pathogen induced gene expression variant || chemical resistant || nose touch variant || drug induced gene expression variant || antimicrobial gene expression variant || thermosensory behavior variant || pathogen induced antimicrobial gene expression variant || odorant positive chemotaxis variant || thermotaxis variant || gene expression variant || organism temperature response variant || organism stress response variant |
| BTB/POZ domain | 0.4349 | INHERITED FROM: protein aggregation induced behavior variant || L1 arrest || resistant to protein aggregation induced paralysis || early larval arrest || chemical hypersensitive |
| Cation efflux protein transmembrane domain-like | 0.4485 | INHERITED FROM: cadmium response variant || manganese response variant || cadmium hypersensitive || chemical hypersensitive || manganese toxicity resistant || metal response variant |
| FKBP immunophilin/proline isomerase | 0.4485 | INHERITED FROM: protein protein interaction variant || transgene subcellular localization variant || protein aggregation variant || protein interaction variant || pattern of transgene expression variant |
| PHD domain | 0.4587 | INHERITED FROM: transgene subcellular localization variant || organism UV hypersensitive || transgene expression variant || RNAi resistant || organism UV response variant || protein modification variant || organism metabolism processing variant || gene expression variant || organism environmental stimulus response variant || protein methylation variant |
| Myosin rod fragments | 0.4902 | INHERITED FROM: sexually dimorphic physiology variant || hermaphrodite physiology variant |
| Pyridoxal-dependent decarboxylase | 0.4902 | INHERITED FROM: carbon dioxide response variant || carbon dioxide avoidance variant || egg laying response to drug variant |
| Hect, E3 ligase catalytic domain | 0.4902 | INHERITED FROM: protein protein interaction variant || germ cell ionizing radiation response variant || transgene subcellular localization variant || protein aggregation induced behavior variant || protein aggregation variant || protein interaction variant || transgene expression variant || cell ionizing radiation response variant || organism metabolism processing variant || gene expression variant || pattern of transgene expression variant |
| Glutathione S-transferase (GST), N-terminal domain | 0.4982 | INHERITED FROM: organism heat hypersensitive || enzyme activity reduced || paraquat response variant || chemical hypersensitive || organism toxic chemical response variant || metal response variant || organism electrophilic stress hypersensitive || enzyme activity variant || organism stress response variant |
| I set domains | 0.5198 | INHERITED FROM: aldicarb response variant || growth rate variant || protein degradation variant |
| Nicotinic receptor ligand binding domain-like | 0.5254 | INHERITED FROM: AWC odorant chemotaxis variant || hypoosmotic shock hypersensitive || benzaldehyde chemotaxis variant || chemical resistant || chemosensory response variant || antihelmintic response variant || mechanosensation variant || nicotine resistant || sodium chloride chemotaxis variant || thermosensory behavior variant || DMPP resistant || DMPP response variant || drug response variant || thermotaxis variant || selenium response variant || slowing response on food variant || cholinergic agonist resistant || organism environmental stimulus response variant || chemical response variant || positive chemotaxis variant |
| Papain-like | 0.5313 | INHERITED FROM: protein protein interaction variant || hypoosmotic shock hypersensitive || osmotic integrity variant || protein aggregation variant || protein interaction variant || transgene expression variant || organism metabolism processing variant || gene expression variant || pattern of transgene expression variant |
| Calpain large subunit, middle domain (domain III) | 0.538 | INHERITED FROM: metabolic pathway variant || protein degradation variant || protein metabolism variant |
| Gastric lipase | 0.538 | INHERITED FROM: fat content variant || lipid metabolism variant |
| Myb/SANT domain | 0.538 | INHERITED FROM: growth rate variant |
| UBC-related | 0.581 | INHERITED FROM: protein protein interaction variant || transgene subcellular localization variant || late larval arrest || protein aggregation variant || protein interaction variant || transgene expression variant || organism metabolism processing variant || gene expression variant || pattern of transgene expression variant |
| WW domain | 0.5834 | INHERITED FROM: maintenance of gene silencing variant |
| Class I alpha-1;2-mannosidase, catalytic domain | 0.5868 | INHERITED FROM: protein protein interaction variant || protein aggregation variant |
| Synaptotagmin-like (S variant) | 0.619 | INHERITED FROM: drug resistant || protein subcellular localization variant || chemical resistant || pattern protein expression variant || drug response variant || acetylcholinesterase inhibitor resistant || acetylcholinesterase inhibitor response variant |
| SH2 domain | 0.625 | INHERITED FROM: protein expression reduced || level of protein expression variant || protein expression variant |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0.6657 | INHERITED FROM: protein protein interaction variant || protein aggregation variant || protein interaction variant || transgene expression variant || organism metabolism processing variant || gene expression variant || pattern of transgene expression variant |
| Frizzled cysteine-rich domain | 0.7034 | INHERITED FROM: antibody staining variant || transgene expression reduced |
| Transforming growth factor (TGF)-beta | 0.7034 | INHERITED FROM: levamisole response variant || level of transgene expression variant || drug response variant || nicotine response variant || transgene expression reduced |
| EF-hand modules in multidomain proteins | 0.7034 | INHERITED FROM: protein expression variant || cell stress response variant |
| Ubiquitin-related | 0.7466 | INHERITED FROM: protein protein interaction variant || protein aggregation variant || protein interaction variant || transgene expression variant || hypersensitive to protein aggregation induced paralysis |
| H-NOX domain | 0.7688 | INHERITED FROM: anesthetic response variant || carbon dioxide response variant || carbon dioxide avoidance variant || drug response variant |
| Cdc48 N-terminal domain-like | 0.7688 | INHERITED FROM: protein protein interaction variant || protein aggregation variant || protein interaction variant || metabolic pathway variant || transgene expression reduced || protein metabolism variant |
| Hemocyanin middle domain | 0.7688 | INHERITED FROM: germ cell ionizing radiation response variant || organism ionizing radiation response variant || cell ionizing radiation response variant || cell stress response variant |
| MIT domain | 0.7688 | INHERITED FROM: protein protein interaction variant || protein aggregation variant || protein interaction variant |
| Bacterial lipase | 0.7688 | INHERITED FROM: fat content variant || lipid metabolism variant |
| Voltage-gated potassium channels | 0.7929 | INHERITED FROM: serotonin response variant || growth rate variant || serotonin resistant || phentolamine resistant || adrenergic receptor antagonist response variant || protein degradation variant |
| LIM domain | 0.8402 | INHERITED FROM: protein expression reduced || level of protein expression variant || protein degradation variant |
| AAT-like | 0.8402 | INHERITED FROM: growth rate variant |
| Cyclophilin (peptidylprolyl isomerase) | 0.8619 | INHERITED FROM: protein protein interaction variant || transgene subcellular localization variant || protein aggregation variant || protein interaction variant || transgene expression variant || pattern of transgene expression variant |
| Glutathione S-transferase (GST), C-terminal domain | 0.8921 | INHERITED FROM: organism heat hypersensitive || enzyme activity reduced || cadmium hypersensitive || metal response variant || organism electrophilic stress hypersensitive || enzyme activity variant || organism stress response variant |
| Leucine zipper domain | 0.9005 | INHERITED FROM: pore forming toxin response variant || pathogen susceptibility increased || level of transgene expression variant || mRNA levels reduced || transgene expression reduced |
| Calmodulin-like | 0.9009 | INHERITED FROM: protein protein interaction variant || protein aggregation variant || protein interaction variant |
| Extended PAW domain | 0.911 | INHERITED FROM: protein protein interaction variant || transgene subcellular localization variant || protein aggregation variant || protein interaction variant || pattern of transgene expression variant |
| SNF-like | 0.911 | INHERITED FROM: drug hypersensitive |
| Thioltransferase | 0.9357 | INHERITED FROM: protein aggregation induced behavior variant |
| NagD-like | 0.9464 | INHERITED FROM: dauer formation variant || dauer development variant || dauer constitutive |
| Ribonuclease PH domain 1-like | 0.9464 | INHERITED FROM: early larval arrest |
| Ribonuclease PH domain 2-like | 0.9464 | INHERITED FROM: early larval arrest |
| Choline/Carnitine O-acyltransferase | 0.9967 | INHERITED FROM: dauer development variant || fat content variant || lipid metabolism variant |
| N-acetyl transferase, NAT | 1 | INHERITED FROM: ectopic expression transgene |
| B-box zinc-binding domain | 1 | INHERITED FROM: protein protein interaction variant || transgene subcellular localization variant || protein aggregation variant || protein interaction variant || transgene expression variant |
| Nuclear receptor | 1 | INHERITED FROM: gene expression level reduced || dauer resistance to harsh conditions variant || gene expression level high || fat content increased || SDS sensitive dauer || transgene expression reduced |
| Nuclear receptor ligand-binding domain | 1 | INHERITED FROM: gene expression level reduced || dauer resistance to harsh conditions variant || gene expression level high || fat content increased || SDS sensitive dauer || transgene expression reduced |
| PAZ domain | 1 | INHERITED FROM: mRNA levels increased || RNAi enhanced || 21U RNA expression variant || somatic transgene silencing variant || siRNA expression variant || RNAi response variant || maintenance of gene silencing variant || RNA expression variant |
| RING finger domain, C3HC4 | 1 | INHERITED FROM: protein protein interaction variant || germ cell ionizing radiation response variant || transgene subcellular localization variant || germ cell hypersensitive ionizing radiation || protein aggregation variant || protein interaction variant || organism metabolism processing variant || pattern of transgene expression variant |
| Rhodopsin-like | 1 | INHERITED FROM: serotonin response variant || aqueous adaptation defective || serotonin induced fat reduction variant || male tail curling serotonin variant || serotonin induced pumping variant || biogenic amine receptor antagonist resistant || locomotion rate serotonin variant || serotonin resistant || egg laying response to drug variant || mianserin resistant || serotonin hypersensitive || drug withdrawal response variant || organism pathogen response variant || methiothepin resistant || cyproheptadine resistant |
| F-box domain | 1 | INHERITED FROM: protein aggregation induced behavior variant || resistant to protein aggregation induced paralysis |
| Glutathione peroxidase-like | 1 | INHERITED FROM: pesticide response variant || paraquat response variant || paraquat hypersensitive || organism toxic chemical response variant |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| HSP90 C-terminal domain | 0 | Direct |
| NOL1/NOP2/sun | 0 | Direct |
| WWE domain | 0 | Direct |
| LEM domain | 0 | Direct |
| Sir2 family of transcriptional regulators | 0 | Direct |
| GABA-aminotransferase-like | 0 | Direct |
| 5' to 3' exonuclease catalytic domain | 0 | Direct |
| PurM N-terminal domain-like | 0 | Direct |
| Cullin repeat | 0 | Direct |
| RecA protein-like (ATPase-domain) | 0 | Direct |
| Glycogenin | 0 | Direct |
| DNA gyrase/MutL, N-terminal domain | 0 | Direct |
| Sec63 C-terminal domain-like | 0 | Direct |
| Adenosine/AMP deaminase | 0 | Direct |
| CoA-binding domain | 0 | Direct |
| Class II glutamine amidotransferases | 0 | Direct |
| Ribosomal protein S10 | 0 | Direct |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0 | Direct |
| Skp1 dimerisation domain-like | 0 | Direct |
| Second domain of FERM | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| Translational machinery components | 0 | Direct |
| Clathrin adaptor core protein | 0 | Direct |
| Acylamino-acid-releasing enzyme, C-terminal donain | 0 | Direct |
| ALDH-like | 0 | Direct |
| Sec7 domain | 0 | Direct |
| DPP6 catalytic domain-like | 0 | Direct |
| Aminoacid dehydrogenase-like, C-terminal domain | 0 | Direct |
| Pancreatic carboxypeptidases | 0 | Direct |
| PDI-like | 0 | Direct |
| Tim10/DDP | 0 | Direct |
| Fatty acid binding protein-like | 0 | Direct |
| Pepsin inhibitor-3 | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| Actin/HSP70 | 0 | Direct |
| Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
| BEACH domain | 0 | Direct |
| L-aminoacid/polyamine oxidase | 0 | Direct |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | Direct |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
| a tRNA synthase domain | 0 | Direct |
| RNA-polymerase beta-prime | 0 | Direct |
| Mitochondrial carrier | 0 | Direct |
| AMPK-beta glycogen binding domain-like | 0 | Direct |
| Intermediate filament protein, coiled coil region | 0 | Direct |
| Arylsulfatase | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| D-aminoacid oxidase, N-terminal domain | 0 | Direct |
| Formate/glycerate dehydrogenases, NAD-domain | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| DPP6 N-terminal domain-like | 0 | Direct |
| Regulator of G-protein signaling, RGS | 0 | Direct |
| Band 7/SPFH domain | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | Direct |
| Acireductone dioxygenase | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | Direct |
| HCDH C-domain-like | 0 | Direct |
| XPF/Rad1/Mus81 nuclease | 0 | Direct |
| CO dehydrogenase ISP C-domain like | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| COMT-like | 0 | Direct |
| Ribokinase-like | 0 | Direct |
| Gamma-glutamyltranspeptidase-like | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| Ribosomal protein L18 and S11 | 0 | Direct |
| HEAT repeat | 0 | Direct |
| La domain | 0 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | Direct |
| 1,3-glucuronyltransferase | 0 | Direct |
| GYF domain | 0 | Direct |
| beta 1,4 galactosyltransferase (b4GalT1) | 0 | Direct |
| VHS domain | 0 | Direct |
| Small-conductance potassium channel | 0 | Direct |
| PhzC/PhzF-like | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| Cadherin | 0 | Direct |
| Elafin-like | 0 | Direct |
| Vertebrate phospholipase A2 | 0 | Direct |
| Ran binding protein zinc finger-like | 0 | Direct |
| Calcium ATPase, transmembrane domain M | 0 | Direct |
| Anticodon-binding domain of Class II aaRS | 0 | Direct |
| Protein prenyltransferases | 0 | Direct |
| PaaI/YdiI-like | 0 | Direct |
| Alcohol dehydrogenase-like, C-terminal domain | 0 | Direct |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | Direct |
| Hedgehog C-terminal (Hog) autoprocessing domain | 0 | Direct |
| CoA transferase alpha subunit-like | 0 | Direct |
| 28-residue LRR | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Clathrin coat assembly domain | 0 | Direct |
| Ubiquitin activating enzymes (UBA) | 0 | Direct |
| MOSC N-terminal domain-like | 0 | Direct |
| Proton glutamate symport protein | 0 | Direct |
| Tubulin, C-terminal domain | 0 | Direct |
| FtsH protease domain-like | 0 | Direct |
| SAM (sterile alpha motif) domain | 0 | Direct |
| Arginine methyltransferase | 0 | Direct |
| RNA editing terminal uridyl transferase 2, RET2, domain 2 | 0 | Direct |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | Direct |
| beta-Lactamase/D-ala carboxypeptidase | 0 | Direct |
| Profilin (actin-binding protein) | 0 | Direct |
| Fibrinogen C-terminal domain-like | 0 | Direct |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | Direct |
| MIR domain | 0 | Direct |
| Glycerol kinase | 0 | Direct |
| YicI catalytic domain-like | 0 | Direct |
| Carboxypeptidase regulatory domain | 0 | Direct |
| Surp module (SWAP domain) | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | Direct |
| LysM domain | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain | 0 | Direct |
| FHA domain | 0 | Direct |
| Armadillo repeat | 0 | Direct |
| acyl-CoA oxidase C-terminal domains | 0 | Direct |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | Direct |
| Molybdenum cofactor-binding domain | 0 | Direct |
| Insulin-like | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | Direct |
| Blood coagulation inhibitor (disintegrin) | 0 | Direct |
| Amylase, catalytic domain | 0 | Direct |
| Mammalian PLC | 0 | Direct |
| TBP-associated factors, TAFs | 0 | Direct |
| Phosphatidylethanolamine binding protein | 0 | Direct |
| alpha-mannosidase | 0 | Direct |
| Internalin LRR domain | 0 | Direct |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | Direct |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | Direct |
| BC C-terminal domain-like | 0 | Direct |
| FF domain | 0 | Direct |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
| Ribosomal protein L1 | 0 | Direct |
| Nucleosome core histones | 0 | Direct |
| Poly(A) polymerase, PAP, N-terminal domain | 0 | Direct |
| Class I glutamine amidotransferases (GAT) | 0 | Direct |
| Chitinase insertion domain | 0 | Direct |
| Class I aldolase | 0 | Direct |
| YihX-like | 0 | Direct |
| Poly(A) polymerase, PAP, middle domain | 0 | Direct |
| Ngr ectodomain-like | 0 | Direct |
| HSP40/DnaJ peptide-binding domain | 0 | Direct |
| Complement control module/SCR domain | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| Phosphate binding protein-like | 0 | Direct |
| Chromo domain | 0 | Direct |
| Clc chloride channel | 0 | Direct |
| Reductases | 0 | Direct |
| Acetyl-CoA synthetase-like | 0 | Direct |
| Methionine aminopeptidase, insert domain | 0 | Direct |
| Pancreatic carboxypeptidase, activation domain | 0 | Direct |
| Pumilio repeat | 0 | Direct |
| Glycolipid transfer protein, GLTP | 0 | Direct |
| POU-specific domain | 0 | Direct |
| Thyroglobulin type-1 domain | 0 | Direct |
| alpha-Amylases, C-terminal beta-sheet domain | 0 | Direct |
| Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 0 | Direct |
| BAR domain | 0 | Direct |
| Trunk domain of Sec23/24 | 0 | Direct |
| DNA gyrase/MutL, second domain | 0 | Direct |
| CAT-like | 0 | Direct |
| Ras-binding domain, RBD | 0 | Direct |
| Dual specificity phosphatase-like | 0 | Direct |
| PLC-like (P variant) | 0 | Direct |
| t-snare proteins | 0 | Direct |
| NLI interacting factor-like phosphatase | 0 | Direct |
| L30e/L7ae ribosomal proteins | 0 | Direct |
| Cell cycle control phosphatase, catalytic domain | 0 | Direct |
| Inositol polyphosphate kinase (IPK) | 0 | Direct |
| ARID domain | 0 | Direct |
| D-aminoacid oxidase-like | 0 | Direct |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0 | Direct |
| SAND domain | 0 | Direct |
| Nop domain | 0 | Direct |
| Nucleoside diphosphate kinase, NDK | 0 | Direct |
| Filamin repeat (rod domain) | 0 | Direct |
| Peptidylglycine alpha-hydroxylating monooxygenase, PHM | 0 | Direct |
| NTF2-like | 0 | Direct |
| Cofilin-like | 0 | Direct |
| Cation efflux protein cytoplasmic domain-like | 0 | Direct |
| Purine and uridine phosphorylases | 0 | Direct |
| Hormone receptor domain | 0 | Direct |
| Matrix metalloproteases, catalytic domain | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| PUA domain | 0 | Direct |
| Double-stranded RNA-binding domain (dsRBD) | 0 | Direct |
| Translation initiation factor eIF4e | 0 | Direct |
| Alcohol dehydrogenase-like, N-terminal domain | 0 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
| MFPT repeat | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
| PDZ domain | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
| MIF4G domain-like | 0 | Direct |
| Pleckstrin-homology domain (PH domain) | 0 | Direct |
| p120GAP domain-like | 0 | Direct |
| Bacterial exopeptidase dimerisation domain | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | Direct |
| LacY-like proton/sugar symporter | 0 | Direct |
| Sec63 N-terminal domain | 0 | Direct |
| Cytoplasmic domain of inward rectifier potassium channel | 0 | Direct |
| Doublecortin (DC) | 0 | Direct |
| BC ATP-binding domain-like | 0 | Direct |
| Biotinyl/lipoyl-carrier proteins and domains | 0 | Direct |
| Ribosomal protein S18 | 0 | Direct |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| DNA repair protein MutS, domain III | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
| Carbonic anhydrase | 0 | Direct |
| PDEase | 0 | Direct |
| Paired domain | 0 | Direct |
| Third domain of FERM | 0 | Direct |
| UDP-glucose pyrophosphorylase | 0 | Direct |
| Chaperone J-domain | 0 | Direct |
| RNA-polymerase beta | 0 | Direct |
| Proprotein convertase P-domain | 0 | Direct |
| Spectrin repeat | 0 | Direct |
| PABC (PABP) domain | 0 | Direct |
| Epoxide hydrolase | 0 | Direct |
| Quinoprotein alcohol dehydrogenase-like | 0 | Direct |
| Poly(ADP-ribose) polymerase, C-terminal domain | 0 | Direct |
| GAS2 domain | 0 | Direct |
| Histone deacetylase, HDAC | 0 | Direct |
| LDH N-terminal domain-like | 0 | Direct |
| Eps15 homology domain (EH domain) | 0 | Direct |
| Tubulin, GTPase domain | 0 | Direct |
| HAT/Suf repeat | 0 | Direct |
| BC N-terminal domain-like | 0 | Direct |
| YWTD domain | 0 | Direct |
| Aquaporin-like | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| SWIRM domain | 0 | Direct |
| Anticodon-binding domain | 0 | Direct |
| First domain of FERM | 0 | Direct |
| Troponin I | 0 | Direct |
| WGR domain | 0 | Direct |
| Laminin G-like module | 0 | Direct |
| Acyl-carrier protein (ACP) | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), catalytic domain | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
| alpha-mannosidase, domain 2 | 0 | Direct |
| PurM C-terminal domain-like | 0 | Direct |
| Heme-dependent catalases | 0 | Direct |
| Retrovirus zinc finger-like domains | 0 | Direct |
| Arfaptin, Rac-binding fragment | 0 | Direct |
| Acyl-CoA thioesterase | 0 | Direct |
| RhoGDI-like | 0 | Direct |
| CUT domain | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| Phosphotyrosine-binding domain (PTB) | 0 | Direct |
| SCF ubiquitin ligase complex WHB domain | 0 | Direct |
| MutT-like | 0 | Direct |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | Direct |
| Sterol carrier protein, SCP | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Annexin | 0 | Direct |
| Rap/Ran-GAP | 0 | Direct |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | Direct |
| Polo-box duplicated region | 0 | Direct |
| Choline kinase | 0 | Direct |
| U-box | 0 | Direct |
| ets domain | 0 | Direct |
| Lactate & malate dehydrogenases, C-terminal domain | 0 | Direct |
| Myeloperoxidase-like | 0 | Direct |
| YbiA-like | 0 | Direct |
| Calpain large subunit, catalytic domain (domain II) | 0 | Direct |
| Hsp90 middle domain | 0 | Direct |
| DEATH domain, DD | 0 | Direct |
| alpha-mannosidase, C-terminal domain | 0 | Direct |
| SMAD domain | 0 | Direct |
| Integrin domains | 0 | Direct |
| Hydantoinase (dihydropyrimidinase), catalytic domain | 0 | Direct |
| NHL repeat | 0 | Direct |
| Glycosyl transferases group 1 | 0 | Direct |
| Poly(A) polymerase, PAP, C-terminal domain | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| Phosphoribosyltransferases (PRTases) | 0 | Direct |
| UBA domain | 0 | Direct |
| DEP domain | 0 | Direct |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | Direct |
| CO dehydrogenase flavoprotein N-terminal domain-like | 0 | Direct |
| Brix domain | 0 | Direct |
| Glutaminase | 0 | Direct |
| HSP20 | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| S-adenosylmethionine synthetase | 0 | Direct |
| ATP-dependent protease Lon (La), catalytic domain | 0 | Direct |
| cAMP-binding domain | 0 | Direct |
| Pyk2-associated protein beta ARF-GAP domain | 0 | Direct |
| Subtilases | 0 | Direct |
| Inositol monophosphatase/fructose-1,6-bisphosphatase-like | 0 | Direct |
| Transducin (alpha subunit), insertion domain | 0 | Direct |
| Biotin dependent carboxylase carboxyltransferase domain | 0 | Direct |
| AN1-like Zinc finger | 0 | Direct |
| Adenain-like | 0 | Direct |
| alpha-catenin/vinculin | 0 | Direct |
| Hexokinase | 0 | Direct |
| Hydantoinase (dihydropyrimidinase) | 0 | Direct |
| Hypothetical protein c14orf129, hspc210 | 0 | Direct |
| Reprolysin-like | 0 | Direct |
| Myotubularin-like phosphatases | 0 | Direct |
| Regulator of chromosome condensation RCC1 | 0 | Direct |
| Ferredoxin reductase FAD-binding domain-like | 0 | Direct |
| Linker histone H1/H5 | 0 | Direct |
| CRAL/TRIO N-terminal domain | 0 | Direct |
| IF2B-like | 0 | Direct |
| Citrate synthase | 0 | Direct |
| Cdc48 domain 2-like | 0 | Direct |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
| Tetraspanin | 0 | Direct |
| GAPDH-like | 0 | Direct |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| PEP carboxykinase C-terminal domain | 0 | Direct |
| Type II chitinase | 0 | Direct |
| Bactericidal permeability-increasing protein, BPI | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| Erythroid transcription factor GATA-1 | 0 | Direct |
| Proteasome subunits | 0 | Direct |
| Glycerophosphoryl diester phosphodiesterase | 0 | Direct |
| acyl-CoA oxidase N-terminal domains | 0 | Direct |
| Single strand DNA-binding domain, SSB | 0 | Direct |
| Thiolase-related | 0 | Direct |
| HD domain | 0 | Direct |
| Oxysterol-binding protein | 0 | Direct |
| Tandem AAA-ATPase domain | 0.003654 | Inherited |
| ABC transporter ATPase domain-like | 0.01003 | Inherited |
| MSP-like | 0.02384 | Inherited |
| Homeodomain | 0.03701 | Inherited |
| ABC transporter transmembrane region | 0.04247 | Inherited |
| WD40-repeat | 0.04718 | Inherited |
| G proteins | 0.04739 | Inherited |
| L-arabinose binding protein-like | 0.05747 | Inherited |
| Protein kinases, catalytic subunit | 0.06104 | Inherited |
| SH3-domain | 0.07439 | Inherited |
| CCCH zinc finger | 0.08576 | Inherited |
| Canonical RBD | 0.1018 | Inherited |
| Extended AAA-ATPase domain | 0.1044 | Inherited |
| Tetratricopeptide repeat (TPR) | 0.1133 | Inherited |
| Cold shock DNA-binding domain-like | 0.1277 | Inherited |
| Motor proteins | 0.1328 | Inherited |
| Adenylyl and guanylyl cyclase catalytic domain | 0.1328 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.1328 | Inherited |
| Calcium ATPase, transduction domain A | 0.1719 | Inherited |
| Cyclin | 0.2094 | Inherited |
| DBL homology domain (DH-domain) | 0.2094 | Inherited |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.2094 | Inherited |
| Elongation factors | 0.2094 | Inherited |
| HMG-box | 0.2094 | Inherited |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.2094 | Inherited |
| Histone lysine methyltransferases | 0.2306 | Inherited |
| Pepsin-like | 0.2306 | Inherited |
| Forkhead DNA-binding domain | 0.2539 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.2539 | Inherited |
| DnaQ-like 3'-5' exonuclease | 0.2539 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.2651 | Inherited |
| Cytochrome P450 | 0.2724 | Inherited |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 0.2793 | Inherited |
| Bromodomain | 0.2793 | Inherited |
| Acetylcholinesterase-like | 0.2898 | Inherited |
| FAD/NAD-linked reductases, N-terminal and central domains | 0.3079 | Inherited |
| Ankyrin repeat | 0.3262 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.3262 | Inherited |
| Crotonase-like | 0.3387 | Inherited |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.3387 | Inherited |
| Meta-cation ATPase, catalytic domain P | 0.3387 | Inherited |
| PX domain | 0.3729 | Inherited |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.4308 | Inherited |
| BTB/POZ domain | 0.4349 | Inherited |
| Cation efflux protein transmembrane domain-like | 0.4485 | Inherited |
| FKBP immunophilin/proline isomerase | 0.4485 | Inherited |
| PHD domain | 0.4587 | Inherited |
| Myosin rod fragments | 0.4902 | Inherited |
| Pyridoxal-dependent decarboxylase | 0.4902 | Inherited |
| Hect, E3 ligase catalytic domain | 0.4902 | Inherited |
| Glutathione S-transferase (GST), N-terminal domain | 0.4982 | Inherited |
| I set domains | 0.5198 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.5254 | Inherited |
| Papain-like | 0.5313 | Inherited |
| Calpain large subunit, middle domain (domain III) | 0.538 | Inherited |
| Gastric lipase | 0.538 | Inherited |
| Myb/SANT domain | 0.538 | Inherited |
| UBC-related | 0.581 | Inherited |
| WW domain | 0.5834 | Inherited |
| Class I alpha-1;2-mannosidase, catalytic domain | 0.5868 | Inherited |
| Synaptotagmin-like (S variant) | 0.619 | Inherited |
| SH2 domain | 0.625 | Inherited |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0.6657 | Inherited |
| Frizzled cysteine-rich domain | 0.7034 | Inherited |
| Transforming growth factor (TGF)-beta | 0.7034 | Inherited |
| EF-hand modules in multidomain proteins | 0.7034 | Inherited |
| Ubiquitin-related | 0.7466 | Inherited |
| H-NOX domain | 0.7688 | Inherited |
| Cdc48 N-terminal domain-like | 0.7688 | Inherited |
| Hemocyanin middle domain | 0.7688 | Inherited |
| MIT domain | 0.7688 | Inherited |
| Bacterial lipase | 0.7688 | Inherited |
| Voltage-gated potassium channels | 0.7929 | Inherited |
| LIM domain | 0.8402 | Inherited |
| AAT-like | 0.8402 | Inherited |
| Cyclophilin (peptidylprolyl isomerase) | 0.8619 | Inherited |
| Glutathione S-transferase (GST), C-terminal domain | 0.8921 | Inherited |
| Leucine zipper domain | 0.9005 | Inherited |
| Calmodulin-like | 0.9009 | Inherited |
| Extended PAW domain | 0.911 | Inherited |
| SNF-like | 0.911 | Inherited |
| Thioltransferase | 0.9357 | Inherited |
| NagD-like | 0.9464 | Inherited |
| Ribonuclease PH domain 1-like | 0.9464 | Inherited |
| Ribonuclease PH domain 2-like | 0.9464 | Inherited |
| Choline/Carnitine O-acyltransferase | 0.9967 | Inherited |
| N-acetyl transferase, NAT | 1 | Inherited |
| B-box zinc-binding domain | 1 | Inherited |
| Nuclear receptor | 1 | Inherited |
| Nuclear receptor ligand-binding domain | 1 | Inherited |
| PAZ domain | 1 | Inherited |
| RING finger domain, C3HC4 | 1 | Inherited |
| Rhodopsin-like | 1 | Inherited |
| F-box domain | 1 | Inherited |
| Glutathione peroxidase-like | 1 | Inherited |
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A presence/absence matrix is generated using protein domain
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this WP term (Not in SPWP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Kringle-like | 0 | DIRECT |
| Nucleotidyltransferase | 0 | DIRECT |
| PurM N-terminal domain-like | 0 | DIRECT |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| Ribosomal protein L10-like | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| Annexin | 0 | DIRECT |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
| Troponin coil-coiled subunits | 0 | DIRECT |
| Intermediate filament protein, coiled coil region | 0 | DIRECT |
| Families 57/38 glycoside transferase middle domain | 0 | DIRECT |
| Insulin-like | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| Cytochrome c | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| PEBP-like | 0 | DIRECT |
| Pentein | 0 | DIRECT |
| WWE domain | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| Tubby C-terminal domain-like | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
| Phoshotransferase/anion transport protein | 0 | DIRECT |
| Rudiment single hybrid motif | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| FtsH protease domain-like | 0 | DIRECT |
| LEM domain | 0 | DIRECT |
| TK C-terminal domain-like | 0 | DIRECT |
| Ferritin-like | 0 | DIRECT |
| Putative DNA-binding domain | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| SAICAR synthase-like | 0 | DIRECT |
| Thyroglobulin type-1 domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Glycolipid transfer protein, GLTP | 0 | DIRECT |
| GroES-like | 0 | DIRECT |
| Citrate synthase | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
| DEATH domain | 0 | DIRECT |
| dsRNA-binding domain-like | 0 | DIRECT |
| PYP-like sensor domain (PAS domain) | 0 | DIRECT |
| Translational machinery components | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| GroEL-intermediate domain like | 0 | DIRECT |
| Carbonic anhydrase | 0 | DIRECT |
| CO dehydrogenase ISP C-domain like | 0 | DIRECT |
| Class I glutamine amidotransferase-like | 0 | DIRECT |
| Tubulin nucleotide-binding domain-like | 0 | DIRECT |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
| Actin-like ATPase domain | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| Aldolase | 0 | DIRECT |
| Cystatin/monellin | 0 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
| GAS2 domain-like | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
| JAB1/MPN domain | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| Chaperone J-domain | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| ADP-ribosylation | 0 | DIRECT |
| Complement control module/SCR domain | 0 | DIRECT |
| MgtE membrane domain-like | 0 | DIRECT |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Thiolase-like | 0 | DIRECT |
| Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
| Ribosomal protein S18 | 0 | DIRECT |
| eIF4e-like | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| Retrovirus zinc finger-like domains | 0 | DIRECT |
| PK beta-barrel domain-like | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | DIRECT |
| Second domain of FERM | 0 | DIRECT |
| GAT-like domain | 0 | DIRECT |
| PIN domain-like | 0 | DIRECT |
| Diaminopimelate epimerase-like | 0 | DIRECT |
| Pepsin inhibitor-3 | 0 | DIRECT |
| Chitinase insertion domain | 0 | DIRECT |
| Aquaporin-like | 0 | DIRECT |
| ArfGap/RecO-like zinc finger | 0 | DIRECT |
| Doublecortin (DC) | 0 | DIRECT |
| Purine and uridine phosphorylases | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| Surp module (SWAP domain) | 0 | DIRECT |
| PurM C-terminal domain-like | 0 | DIRECT |
| Tubulin C-terminal domain-like | 0 | DIRECT |
| HSP20-like chaperones | 0 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
| Molybdenum cofactor biosynthesis proteins | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| CAD & PB1 domains | 0 | DIRECT |
| Cullin repeat-like | 0 | DIRECT |
| alpha-catenin/vinculin-like | 0 | DIRECT |
| Tricorn protease domain 2 | 0 | DIRECT |
| MFPT repeat-like | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Mitochondrial carrier | 0 | DIRECT |
| HCP-like | 0 | DIRECT |
| t-snare proteins | 0 | DIRECT |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| GroEL equatorial domain-like | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| ACP-like | 0 | DIRECT |
| GYF domain | 0 | DIRECT |
| Nucleoside diphosphate kinase, NDK | 0 | DIRECT |
| HRDC-like | 0 | DIRECT |
| ENTH/VHS domain | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| Carboxypeptidase regulatory domain-like | 0 | DIRECT |
| cAMP-binding domain-like | 0 | DIRECT |
| Single hybrid motif | 0 | DIRECT |
| Carbon-nitrogen hydrolase | 0 | DIRECT |
| PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | DIRECT |
| Galactose oxidase, central domain | 0 | DIRECT |
| beta-lactamase/transpeptidase-like | 0 | DIRECT |
| ThrRS/AlaRS common domain | 0 | DIRECT |
| Invertebrate chitin-binding proteins | 0 | DIRECT |
| Ribosomal L27 protein-like | 0 | DIRECT |
| CBD9-like | 0 | DIRECT |
| Galactose mutarotase-like | 0 | DIRECT |
| Tim10-like | 0 | DIRECT |
| SCP-like | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0 | DIRECT |
| Ribosomal protein S10 | 0 | DIRECT |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | DIRECT |
| Elafin-like | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| Zn-binding ribosomal proteins | 0 | DIRECT |
| Skp1 dimerisation domain-like | 0 | DIRECT |
| Cadherin-like | 0 | DIRECT |
| Terpenoid synthases | 0 | DIRECT |
| Radical SAM enzymes | 0 | DIRECT |
| Cdc48 domain 2-like | 0 | DIRECT |
| Protease propeptides/inhibitors | 0 | DIRECT |
| Band 7/SPFH domain | 0 | DIRECT |
| GroEL apical domain-like | 0 | DIRECT |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
| Spectrin repeat | 0 | DIRECT |
| Creatinase/prolidase N-terminal domain | 0 | DIRECT |
| S-adenosylmethionine synthetase | 0 | DIRECT |
| SAND domain-like | 0 | DIRECT |
| Sec7 domain | 0 | DIRECT |
| NagB/RpiA/CoA transferase-like | 0 | DIRECT |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| Subtilisin-like | 0 | DIRECT |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | DIRECT |
| Hormone receptor domain | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| Heme-dependent peroxidases | 0 | DIRECT |
| PLC-like phosphodiesterases | 0 | DIRECT |
| TGS-like | 0 | DIRECT |
| PAP/OAS1 substrate-binding domain | 0 | DIRECT |
| PUA domain-like | 0 | DIRECT |
| L30e-like | 0 | DIRECT |
| Hedgehog/intein (Hint) domain | 0 | DIRECT |
| PHM/PNGase F | 0 | DIRECT |
| PABC (PABP) domain | 0 | DIRECT |
| MOSC N-terminal domain-like | 0 | DIRECT |
| ISP domain | 0 | DIRECT |
| Rap/Ran-GAP | 0 | DIRECT |
| RBP11-like subunits of RNA polymerase | 0 | DIRECT |
| Clc chloride channel | 0 | DIRECT |
| alpha/beta knot | 0 | DIRECT |
| PreATP-grasp domain | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| Sec63 N-terminal domain-like | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Molybdenum cofactor-binding domain | 0 | DIRECT |
| Carbohydrate phosphatase | 0 | DIRECT |
| CRAL/TRIO N-terminal domain | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| Hypothetical protein c14orf129, hspc210 | 0 | DIRECT |
| AN1-like Zinc finger | 0 | DIRECT |
| Activating enzymes of the ubiquitin-like proteins | 0 | DIRECT |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | DIRECT |
| Profilin (actin-binding protein) | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Histone-fold | 0 | DIRECT |
| Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
| FAD-linked oxidases, C-terminal domain | 0 | DIRECT |
| ARID-like | 0 | DIRECT |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| Ribosomal proteins S24e, L23 and L15e | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
| Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
| Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
| Class II aaRS ABD-related | 0 | DIRECT |
| Acyl-CoA dehydrogenase NM domain-like | 0 | DIRECT |
| R3H domain | 0 | DIRECT |
| Small-conductance potassium channel | 0 | DIRECT |
| Restriction endonuclease-like | 0 | DIRECT |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Nucleoporin domain | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| 2Fe-2S ferredoxin-like | 0 | DIRECT |
| WGR domain-like | 0 | DIRECT |
| Fibrinogen C-terminal domain-like | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| L-aspartase-like | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Oxysterol-binding protein-like | 0 | DIRECT |
| Polo-box domain | 0 | DIRECT |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | DIRECT |
| YbiA-like | 0 | DIRECT |
| FAD-binding/transporter-associated domain-like | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| Chromo domain-like | 0 | DIRECT |
| Ribokinase-like | 0 | DIRECT |
| Heme-dependent catalase-like | 0 | DIRECT |
| Ribosomal protein L1 | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| Periplasmic binding protein-like II | 0 | DIRECT |
| SIS domain | 0 | DIRECT |
| Ran binding protein zinc finger-like | 0 | DIRECT |
| Integrin alpha N-terminal domain | 0 | DIRECT |
| PEP carboxykinase-like | 0 | DIRECT |
| DNA repair protein MutS, domain III | 0 | DIRECT |
| Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
| Acetyl-CoA synthetase-like | 0 | DIRECT |
| VPS9 domain | 0 | DIRECT |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0 | DIRECT |
| Outer arm dynein light chain 1 | 0 | DIRECT |
| BEACH domain | 0 | DIRECT |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | DIRECT |
| PGBD-like | 0 | DIRECT |
| LDH C-terminal domain-like | 0 | DIRECT |
| lambda repressor-like DNA-binding domains | 0 | DIRECT |
| LysM domain | 0 | DIRECT |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| Arginase/deacetylase | 0 | DIRECT |
| YWTD domain | 0 | DIRECT |
| P-loop containing nucleoside triphosphate hydrolases | 0.0000003335 | DIRECT |
| PH domain-like | 0.0000176 | DIRECT |
| PapD-like | 0.007762 | INHERITED FROM: larval growth variant || larval arrest || dauer lifespan variant || lipid metabolism variant || slow growth || dauer metabolism variant || fat content variant || developmental growth variant || dauer lifespan extended |
| PDZ domain-like | 0.007917 | INHERITED FROM: acetylcholinesterase inhibitor response variant || chemical resistant || drug resistant || aldicarb response variant || protein expression variant |
| TPR-like | 0.01127 | INHERITED FROM: ivermectin response variant || light body touch resistant || antihelmintic response variant || positive chemotaxis defective || ivermectin resistant || chemotaxis variant || dauer development variant |
| Periplasmic binding protein-like I | 0.01257 | INHERITED FROM: magnesium chemotaxis defective || organism temperature response variant || chemosensory response variant || carbon dioxide avoidance variant || diacetyl chemotaxis variant || AWC odorant chemotaxis defective || AWC odorant chemotaxis variant || memory retention defective || aqueous positive chemotaxis variant || organism environmental stimulus response variant || thermotaxis variant || alkaline pH chemotaxis variant || thermosensory behavior variant || aqueous chemosensory response variant || bromide chemotaxis variant || iodide chemotaxis defective || carbon dioxide response variant || bromide chemotaxis defective || second messenger mediated signaling variant || chemotaxis variant || mechanosensation variant || lithium chemotaxis defective || iodide chemotaxis variant || benzaldehyde chemotaxis variant |
| ABC transporter transmembrane region | 0.01777 | INHERITED FROM: chemical hypersensitive || cadmium hypersensitive || metal response variant || cadmium response variant || RNAi resistant || RNAi response variant || chemical response variant || colchicine hypersensitive |
| ARM repeat | 0.01833 | INHERITED FROM: sexually dimorphic physiology variant || organism metabolism processing variant || RNAi response variant || protein expression variant || sick || gene expression variant |
| Protein kinase-like (PK-like) | 0.03384 | INHERITED FROM: conflicting sensory integration variant || octanol chemotaxis defective || organism oxidative stress response variant || hypoxia response variant || mid larval arrest || transgene expression reduced || protein phosphorylation reduced || metal response variant || life span variant || copper hypersensitive || metabolic pathway variant || aldicarb response variant || drug induced gene expression variant || organism environmental stimulus response variant || positive chemotaxis variant || kinase activity reduced || protein expression variant || alkaline pH chemotaxis variant || aqueous chemosensory response variant || lipid synthesis increased || protein subcellular localization variant || larval physiology variant || protein phosphorylation variant || egg laying response to food variant || chemical response variant || protein modification variant || organism osmotic stress hypersensitive || second messenger mediated signaling variant || dauer development variant || mechanosensation variant || colchicine resistant || anoxia resistant |
| SH3-domain | 0.04295 | INHERITED FROM: aldicarb response variant || protein expression variant || protein phosphorylation variant || protein expression reduced || protein metabolism variant |
| Nucleic acid-binding proteins | 0.04295 | INHERITED FROM: hermaphrodite physiology variant || sexually dimorphic physiology variant || avoids bacterial lawn || mRNA surveillance defective || hydroxyurea hypersensitive || organism environmental stimulus response variant || hypoxia resistant || sick || nonsense mRNA accumulation || hydroxyurea response variant |
| Homeodomain-like | 0.04914 | INHERITED FROM: adrenergic receptor antagonist response variant || egg laying imipramine resistant || protein degradation variant || carbon dioxide avoidance variant || phentolamine resistant || ectopic expression transgene || organism metabolism processing variant || growth rate variant || level of transgene expression variant || imipramine resistant || carbon dioxide response variant |
| WD40 repeat-like | 0.05855 | INHERITED FROM: protein protein interaction variant || hermaphrodite physiology variant || sexually dimorphic physiology variant || organism metabolism processing variant || pathogen induced antimicrobial gene expression variant || aldicarb response variant || protein aggregation induced behavior variant || osmotic avoidance variant || late larval arrest || early larval arrest || protein aggregation variant |
| CCCH zinc finger | 0.06257 | INHERITED FROM: transgene expression variant || mRNA expression ectopic || ectopic expression transgene || gene expression variant |
| FYVE/PHD zinc finger | 0.0717 | INHERITED FROM: organism UV response variant || organism metabolism processing variant || organism UV hypersensitive || protein methylation variant || protein modification variant || gene expression variant |
| Translation proteins | 0.07824 | INHERITED FROM: protein protein interaction variant || transgene expression variant || proteasome core activity variant || hermaphrodite physiology variant || sexually dimorphic physiology variant || organism metabolism processing variant || mRNA levels increased || receptor mediated endocytosis defective || sick || oocyte physiology variant || protein phosphorylation variant || protein aggregation variant || gene expression variant || protein phosphorylation increased |
| "Winged helix" DNA-binding domain | 0.0889 | INHERITED FROM: protein protein interaction variant || anesthetic response variant || organism metabolism processing variant || life span variant || protein aggregation induced behavior variant || germline transgene silencing variant || protein expression increased || spontaneous mutation rate increased || protein aggregation variant |
| Nucleotide cyclase | 0.09226 | INHERITED FROM: magnesium chemotaxis defective || chemosensory response variant || diacetyl chemotaxis variant || AWC odorant chemotaxis defective || cation positive chemotaxis variant || anesthetic response variant || AWC odorant chemotaxis variant || osmotic avoidance variant || organism environmental stimulus response variant || positive chemotaxis variant || thermotaxis variant || alkaline pH chemotaxis variant || aqueous chemosensory response variant || bromide chemotaxis variant || iodide chemotaxis defective || chemical response variant || carbon dioxide response variant || bromide chemotaxis defective || second messenger mediated signaling variant || chemotaxis variant || anion positive chemotaxis defective || anion positive chemotaxis variant || cation positive chemotaxis defective || lithium chemotaxis defective || iodide chemotaxis variant |
| HLH, helix-loop-helix DNA-binding domain | 0.09226 | INHERITED FROM: hypoxia response variant || ectopic expression transgene || organism metabolism processing variant || aqueous positive chemotaxis defective || RNA expression variant || fungal resistance increased || pathogen resistance increased || gene expression level reduced || lysine chemotaxis defective |
| SMAD/FHA domain | 0.09799 | INHERITED FROM: aldicarb response variant || dauer development variant || fat content reduced |
| Calcium ATPase, transmembrane domain M | 0.1096 | INHERITED FROM: lipid composition variant || drug hypersensitive || nicotine hypersensitive |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1226 | INHERITED FROM: lipid composition variant || drug hypersensitive || nicotine hypersensitive |
| Regulator of G-protein signaling, RGS | 0.1226 | INHERITED FROM: negative chemotaxis variant || chemotaxis variant || mechanosensation variant |
| EGF/Laminin | 0.1279 | INHERITED FROM: octanol chemotaxis defective || octanol chemotaxis variant || odorant negative chemotaxis defective |
| Acid proteases | 0.1367 | INHERITED FROM: protein protein interaction variant || transgene expression variant || osmotic integrity variant || protein interaction variant || transgene subcellular localization variant || organism metabolism processing variant || hypoosmotic shock hypersensitive || protein aggregation variant || gene expression variant |
| Calcium ATPase, transduction domain A | 0.1367 | INHERITED FROM: drug hypersensitive || organism environmental stimulus response variant || nicotine hypersensitive |
| Cysteine-rich domain | 0.1451 | INHERITED FROM: acetylcholinesterase inhibitor response variant || odorant chemosensory response variant || bacterially unswollen || odorant positive chemotaxis variant || organism metabolism processing variant || pathogen induced antimicrobial gene expression variant || antimicrobial gene expression variant || aldicarb response variant || drug induced gene expression variant || positive chemotaxis variant || thermotaxis variant || thermosensory behavior variant || protein subcellular localization variant || organism stress response variant || pathogen induced gene expression variant || response to injury variant || gene expression variant |
| Quinoprotein alcohol dehydrogenase-like | 0.1529 | INHERITED FROM: hypoxia response variant || mid larval arrest || protein degradation variant || oxygen response variant || mRNA levels increased || L2 arrest |
| Multidrug efflux transporter AcrB transmembrane domain | 0.1585 | INHERITED FROM: odorant chemosensory response variant || odorant positive chemotaxis defective || egg integrity defective early emb || positive chemotaxis defective || embryo osmotic integrity defective early emb || chemotaxis variant |
| HMG-box | 0.1707 | INHERITED FROM: transgene expression variant || anesthetic response variant || maintenance of gene silencing variant |
| DBL homology domain (DH-domain) | 0.1707 | INHERITED FROM: bacterially unswollen || aldicarb response variant || organism environmental stimulus response variant || response to bacteria variant || pathogen resistance increased || organism pathogen response variant |
| ClpP/crotonase | 0.1707 | INHERITED FROM: lipid metabolism variant || fat content variant || level of transgene expression variant |
| Cytochrome P450 | 0.1734 | INHERITED FROM: cadmium hypersensitive || metal response variant || cadmium response variant || metabolite content decreased |
| (Trans)glycosidases | 0.1836 | INHERITED FROM: pathogen susceptibility increased |
| Ankyrin repeat | 0.199 | INHERITED FROM: octanol chemotaxis defective || chemosensory response variant || octanol chemotaxis variant || organism heat response variant || odorant negative chemotaxis defective || chemotaxis variant |
| Cyclin-like | 0.2234 | INHERITED FROM: protein phosphorylation reduced || level of transgene expression variant || protein phosphorylation variant |
| Cysteine proteinases | 0.2338 | INHERITED FROM: protein protein interaction variant || osmotic integrity variant || protein interaction variant || organism metabolism processing variant || hypoosmotic shock hypersensitive || paraquat hypersensitive || pattern of transgene expression variant || protein aggregation variant |
| Bromodomain | 0.2365 | INHERITED FROM: organism UV response variant || anesthetic response variant || organism metabolism processing variant || anesthetic resistant || organism UV hypersensitive || sick || ethanol resistant || gene expression variant || drug adaptation variant || acute functional tolerance to alcohol defective |
| Tudor/PWWP/MBT | 0.2365 | INHERITED FROM: pattern of transgene expression variant |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.2365 | INHERITED FROM: lipid metabolism variant || fat content variant |
| POZ domain | 0.2544 | INHERITED FROM: L1 arrest || protein aggregation induced behavior variant || early larval arrest || resistant to protein aggregation induced paralysis |
| SNARE-like | 0.2638 | INHERITED FROM: acetylcholinesterase inhibitor resistant || transgene expression variant || transgene subcellular localization variant || organism metabolism processing variant || aldicarb resistant || sick || pattern of transgene expression variant || gene expression variant |
| Lipocalins | 0.264 | INHERITED FROM: fat content increased || paraquat hypersensitive || lipid metabolism variant || fat content variant |
| Metallo-dependent phosphatases | 0.2696 | INHERITED FROM: germ cell resistant ionizing radiation || radiation induced germ cell apoptosis variant |
| RNA-binding domain, RBD | 0.2851 | INHERITED FROM: starvation induced apoptosis variant || RNA metabolism variant || organism metabolism processing variant || pathogen induced antimicrobial gene expression variant || RNA processing variant || RNA expression variant || maintenance of gene silencing variant || mRNA export variant || sick || no induction of antimicrobial peptide expression after infection || alternative splicing variant || innate immune response variant |
| DNA/RNA polymerases | 0.294 | INHERITED FROM: organism UV response variant || DNA metabolism variant || organism UV hypersensitive |
| PX domain | 0.3269 | INHERITED FROM: protein expression variant || protein subcellular localization variant || protein expression reduced |
| Translation proteins SH3-like domain | 0.3269 | INHERITED FROM: protein protein interaction variant || transgene expression variant || organism metabolism processing variant || avoids bacterial lawn || organism environmental stimulus response variant || response to bacteria variant || early larval arrest || protein aggregation variant || gene expression variant |
| Cation efflux protein transmembrane domain-like | 0.3269 | INHERITED FROM: manganese response variant || cadmium hypersensitive || metal response variant || manganese toxicity resistant |
| HAD-like | 0.3502 | INHERITED FROM: nicotine hypersensitive |
| Nicotinic receptor ligand binding domain-like | 0.3658 | INHERITED FROM: cholinergic agonist resistant || chemosensory response variant || chemical resistant || AWC odorant chemotaxis variant || hypoosmotic shock hypersensitive || nicotine resistant || DMPP resistant || organism environmental stimulus response variant || antihelmintic response variant || positive chemotaxis variant || DMPP response variant || thermotaxis variant || thermosensory behavior variant || selenium response variant || chemical response variant || slowing response on food variant || mechanosensation variant || drug response variant || sodium chloride chemotaxis variant || benzaldehyde chemotaxis variant |
| PLP-dependent transferases | 0.3721 | INHERITED FROM: germ cell resistant ionizing radiation || radiation induced germ cell apoptosis variant |
| Ubiquitin-like | 0.3821 | INHERITED FROM: protein protein interaction variant || heteroplasmy || protein interaction variant || protein aggregation variant |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.402 | INHERITED FROM: cholinergic agonist resistant || chemosensory response variant || chemical resistant || AWC odorant chemotaxis variant || hypoosmotic shock hypersensitive || nicotine resistant || DMPP resistant || organism environmental stimulus response variant || antihelmintic response variant || positive chemotaxis variant || DMPP response variant || thermotaxis variant || thermosensory behavior variant || selenium response variant || chemical response variant || slowing response on food variant || mechanosensation variant || drug response variant || sodium chloride chemotaxis variant || benzaldehyde chemotaxis variant |
| HD-domain/PDEase-like | 0.4026 | INHERITED FROM: organism temperature response variant || thermotaxis variant || thermosensory behavior variant |
| FKBP-like | 0.4026 | INHERITED FROM: protein protein interaction variant || protein interaction variant || transgene subcellular localization variant || pattern of transgene expression variant || protein aggregation variant |
| RNI-like | 0.405 | INHERITED FROM: resistant to protein aggregation induced paralysis |
| Class II aaRS and biotin synthetases | 0.4203 | INHERITED FROM: hypoxia response variant || transgene expression variant || hermaphrodite physiology variant || oxygen response variant || sexually dimorphic physiology variant || organism metabolism processing variant || avoids bacterial lawn || organism environmental stimulus response variant || response to bacteria variant || hypoxia resistant || receptor mediated endocytosis defective || oocyte physiology variant || gene expression variant |
| DHS-like NAD/FAD-binding domain | 0.4474 | INHERITED FROM: metabolic pathway variant || protein expression variant || protein acetylation variant |
| Myosin rod fragments | 0.4474 | INHERITED FROM: hermaphrodite physiology variant || drug resistant || sexually dimorphic physiology variant |
| PRTase-like | 0.4474 | INHERITED FROM: drug resistant || Fluorouracil resistant |
| Hect, E3 ligase catalytic domain | 0.4474 | INHERITED FROM: protein protein interaction variant || transgene expression variant || protein interaction variant || transgene subcellular localization variant || organism metabolism processing variant || protein aggregation induced behavior variant || pattern of transgene expression variant || germ cell ionizing radiation response variant || cell ionizing radiation response variant || protein aggregation variant || gene expression variant |
| Galactose-binding domain-like | 0.4806 | INHERITED FROM: protein protein interaction variant || protein interaction variant || protein aggregation variant |
| Ribosomal protein S5 domain 2-like | 0.4806 | INHERITED FROM: early larval arrest |
| Sm-like ribonucleoproteins | 0.4836 | INHERITED FROM: transgene expression variant || unfolded protein response variant || hermaphrodite physiology variant || sexually dimorphic physiology variant || life span variant || avoids bacterial lawn || response to bacteria variant || receptor mediated endocytosis defective || organism heat response variant || sick || protein subcellular localization variant || pattern of transgene expression variant |
| Cystine-knot cytokines | 0.4836 | INHERITED FROM: levamisole response variant || nicotine response variant |
| SH2 domain | 0.4928 | INHERITED FROM: protein expression variant || level of protein expression variant || protein expression reduced |
| Calpain large subunit, middle domain (domain III) | 0.4934 | INHERITED FROM: protein degradation variant || metabolic pathway variant || protein metabolism variant |
| Riboflavin synthase domain-like | 0.4934 | INHERITED FROM: pattern protein expression variant |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.4934 | INHERITED FROM: pattern protein expression variant |
| Zinc beta-ribbon | 0.4934 | INHERITED FROM: receptor mediated endocytosis defective |
| FAD/NAD(P)-binding domain | 0.5099 | INHERITED FROM: organism oxidative stress response variant || ATP levels reduced || life span variant || ATP levels variant || pesticide response variant || organism toxic chemical response variant |
| WW domain | 0.52 | INHERITED FROM: acetylcholinesterase inhibitor resistant || aldicarb resistant || maintenance of gene silencing variant |
| FAD-linked reductases, C-terminal domain | 0.52 | INHERITED FROM: life span variant |
| Voltage-gated potassium channels | 0.5279 | INHERITED FROM: adrenergic receptor antagonist response variant || protein degradation variant || serotonin resistant || phentolamine resistant || growth rate variant || serotonin response variant || positive chemotaxis defective || imipramine resistant || mechanosensation variant |
| SAM/Pointed domain | 0.5289 | INHERITED FROM: aldicarb response variant || gene expression level reduced |
| Nucleotidylyl transferase | 0.5289 | INHERITED FROM: hypoxia response variant || oxygen response variant || organism metabolism processing variant || avoids bacterial lawn || transgene expression increased || paraquat resistant || organism environmental stimulus response variant || response to bacteria variant || hypoxia resistant |
| SET domain | 0.5324 | INHERITED FROM: histone methylation variant || shortened life span || dosage compensation variant || organism metabolism processing variant || life span variant || ectopic expression antibody || protein methylation variant || maintenance of gene silencing variant || spontaneous mutation rate increased || RNAi response variant || pattern of transgene expression variant || protein modification variant || protein metabolism variant || gene expression variant |
| UBC-like | 0.5324 | INHERITED FROM: protein protein interaction variant || protein interaction variant || transgene subcellular localization variant || organism metabolism processing variant || late larval arrest || sick || pattern of transgene expression variant || protein aggregation variant |
| Seven-hairpin glycosidases | 0.5481 | INHERITED FROM: protein protein interaction variant || extended life span || protein aggregation variant |
| Multidrug resistance efflux transporter EmrE | 0.5551 | INHERITED FROM: bacterially unswollen || response to bacteria variant || pathogen resistance increased |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.5927 | INHERITED FROM: cellular osmotic stress response variant || chemical resistant || drug resistant || cell stress response variant || gonad sheath contractions variant || pathogen induced antimicrobial gene expression variant || growth rate variant || drug induced gene expression variant || somatic sheath physiology variant || organism environmental stimulus response variant || egg laying serotonin variant || organism osmotic stress response variant || RNAi response variant || protein expression variant || protein subcellular localization variant || chemical response variant || response to injury variant || aging variant || gonad sheath contraction rate reduced |
| Di-copper centre-containing domain | 0.6034 | INHERITED FROM: cell stress response variant || organism ionizing radiation response variant || germ cell ionizing radiation response variant || organism stress response variant || cell ionizing radiation response variant |
| Nucleotide-binding domain | 0.6034 | INHERITED FROM: extended life span |
| KA1-like | 0.6034 | INHERITED FROM: RNA expression variant |
| HIT/MYND zinc finger-like | 0.6318 | INHERITED FROM: pattern of transgene expression variant |
| S-adenosyl-L-methionine-dependent methyltransferases | 0.641 | INHERITED FROM: gamma ray induced apoptosis increased || cell gamma ray response variant || organism gamma ray response variant |
| MFS general substrate transporter | 0.6418 | INHERITED FROM: organism high sodium chloride hypersensitive |
| S15/NS1 RNA-binding domain | 0.6688 | INHERITED FROM: avoids bacterial lawn || transgene expression increased || response to bacteria variant |
| 4Fe-4S ferredoxins | 0.6688 | INHERITED FROM: life span variant || transgene expression increased |
| Frizzled cysteine-rich domain | 0.6688 | INHERITED FROM: transgene expression reduced || antibody staining variant |
| DNase I-like | 0.6727 | INHERITED FROM: protein expression variant |
| GST C-terminal domain-like | 0.6824 | INHERITED FROM: organism electrophilic stress hypersensitive || cadmium hypersensitive || metal response variant || organism environmental stimulus response variant || organism heat hypersensitive || organism stress response variant || enzyme activity reduced || enzyme activity variant |
| MIT domain | 0.7394 | INHERITED FROM: protein protein interaction variant || protein interaction variant || protein aggregation variant |
| ADC-like | 0.7394 | INHERITED FROM: protein protein interaction variant || transgene expression reduced || protein interaction variant || metabolic pathway variant || protein metabolism variant || protein aggregation variant |
| Fibronectin type III | 0.7435 | INHERITED FROM: growth rate variant |
| alpha/beta-Hydrolases | 0.7453 | INHERITED FROM: acetylcholinesterase reduced || acetylcholinesterase activity variant |
| EF-hand | 0.7469 | INHERITED FROM: cellular osmotic stress response variant || protein interaction variant || gonad sheath contractions variant || aldicarb response variant || somatic sheath physiology variant || protein aggregation variant |
| Clavaminate synthase-like | 0.7957 | INHERITED FROM: histone methylation variant || life span variant || protein methylation variant |
| NAD kinase/diacylglycerol kinase-like | 0.7985 | INHERITED FROM: thermotaxis variant || thermosensory behavior variant |
| Ribonuclease H-like | 0.7985 | INHERITED FROM: somatic transgene silencing variant || siRNA expression variant || RNA expression variant || 21U RNA expression variant || maintenance of gene silencing variant || RNAi response variant || RNAi enhanced |
| Cyclophilin-like | 0.8089 | INHERITED FROM: protein protein interaction variant || transgene expression variant || protein interaction variant || transgene subcellular localization variant || pattern of transgene expression variant || protein aggregation variant || gene expression variant |
| CoA-dependent acyltransferases | 0.8089 | INHERITED FROM: organism metabolism processing variant || lipid metabolism variant || dauer development variant |
| UBA-like | 0.8205 | INHERITED FROM: protein protein interaction variant || protein aggregation variant |
| SNF-like | 0.8404 | INHERITED FROM: drug hypersensitive |
| Leucine zipper domain | 0.8473 | INHERITED FROM: transgene expression reduced || pore forming toxin response variant || level of transgene expression variant || mRNA levels reduced || mRNA expression variant || pathogen susceptibility increased |
| Eukaryotic type KH-domain (KH-domain type I) | 0.8567 | INHERITED FROM: RNA expression variant |
| GTPase activation domain, GAP | 0.8567 | INHERITED FROM: protein expression variant |
| Thioredoxin-like | 0.8913 | INHERITED FROM: organism electrophilic stress hypersensitive || paraquat response variant || metal response variant || organism heat hypersensitive || organism stress response variant || organism toxic chemical response variant || enzyme activity reduced || enzyme activity variant |
| p53-like transcription factors | 0.8962 | INHERITED FROM: ectopic expression transgene || level of transgene expression variant || gene expression level reduced |
| Immunoglobulin | 0.9033 | INHERITED FROM: protein degradation variant || growth rate variant || aldicarb response variant |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.9054 | INHERITED FROM: transgene expression reduced || SDS sensitive dauer || fat content increased || dauer resistance to harsh conditions variant || level of transgene expression variant || gene expression level high || gene expression level reduced |
| Ribonuclease PH domain 2-like | 0.9222 | INHERITED FROM: early larval arrest |
| Nucleotide-diphospho-sugar transferases | 0.9267 | INHERITED FROM: resistant to lectin || lectin response variant |
| Saposin | 0.9491 | INHERITED FROM: increased pathogen survival || transgene expression reduced || germ cell resistant ionizing radiation || radiation induced germ cell apoptosis variant || level of transgene expression variant || germ cell ionizing radiation response variant || pathogen load variant |
| PAZ domain | 0.9843 | INHERITED FROM: somatic transgene silencing variant || siRNA expression variant || RNA expression variant || mRNA levels increased || 21U RNA expression variant || maintenance of gene silencing variant || RNAi response variant || RNAi enhanced |
| Ligand-binding domain in the NO signalling and Golgi transport | 0.9938 | INHERITED FROM: carbon dioxide avoidance variant || anesthetic response variant || chemical response variant || carbon dioxide response variant || drug response variant |
| beta-beta-alpha zinc fingers | 1 | INHERITED FROM: egg laying imipramine resistant || egg laying serotonin resistant || organism metabolism processing variant || imipramine resistant || inhibitor of serotonin uptake variant |
| B-box zinc-binding domain | 1 | INHERITED FROM: protein protein interaction variant || transgene expression variant || protein interaction variant || transgene subcellular localization variant || organism metabolism processing variant || protein aggregation variant || gene expression variant |
| Nuclear receptor ligand-binding domain | 1 | INHERITED FROM: transgene expression reduced || SDS sensitive dauer || fat content increased || lipid metabolism variant || dauer resistance to harsh conditions variant || level of transgene expression variant || gene expression level high || gene expression level reduced |
| Bet v1-like | 1 | INHERITED FROM: growth rate variant |
| RING/U-box | 1 | INHERITED FROM: protein protein interaction variant || protein interaction variant || cell stress response variant || transgene subcellular localization variant || organism ionizing radiation response variant || organism metabolism processing variant || germ cell hypersensitive ionizing radiation || pattern of transgene expression variant || germ cell ionizing radiation response variant || cell ionizing radiation response variant || protein aggregation variant || gene expression variant |
| Family A G protein-coupled receptor-like | 1 | INHERITED FROM: locomotion rate serotonin variant || male tail curling serotonin variant || serotonin induced pumping variant || serotonin induced fat reduction variant |
| Snake toxin-like | 1 | INHERITED FROM: fat content reduced |
| F-box domain | 1 | INHERITED FROM: resistant to protein aggregation induced paralysis |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Kringle-like | 0 | Direct |
| Nucleotidyltransferase | 0 | Direct |
| PurM N-terminal domain-like | 0 | Direct |
| Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
| Ribosomal protein L10-like | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| Annexin | 0 | Direct |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
| Troponin coil-coiled subunits | 0 | Direct |
| Intermediate filament protein, coiled coil region | 0 | Direct |
| Families 57/38 glycoside transferase middle domain | 0 | Direct |
| Insulin-like | 0 | Direct |
| ALDH-like | 0 | Direct |
| Cytochrome c | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| PEBP-like | 0 | Direct |
| Pentein | 0 | Direct |
| WWE domain | 0 | Direct |
| Integrin domains | 0 | Direct |
| Tubby C-terminal domain-like | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Bacterial exopeptidase dimerisation domain | 0 | Direct |
| Phoshotransferase/anion transport protein | 0 | Direct |
| Rudiment single hybrid motif | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| Proton glutamate symport protein | 0 | Direct |
| FtsH protease domain-like | 0 | Direct |
| LEM domain | 0 | Direct |
| TK C-terminal domain-like | 0 | Direct |
| Ferritin-like | 0 | Direct |
| Putative DNA-binding domain | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| SAICAR synthase-like | 0 | Direct |
| Thyroglobulin type-1 domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Glycolipid transfer protein, GLTP | 0 | Direct |
| GroES-like | 0 | Direct |
| Citrate synthase | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
| DEATH domain | 0 | Direct |
| dsRNA-binding domain-like | 0 | Direct |
| PYP-like sensor domain (PAS domain) | 0 | Direct |
| Translational machinery components | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| GroEL-intermediate domain like | 0 | Direct |
| Carbonic anhydrase | 0 | Direct |
| CO dehydrogenase ISP C-domain like | 0 | Direct |
| Class I glutamine amidotransferase-like | 0 | Direct |
| Tubulin nucleotide-binding domain-like | 0 | Direct |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
| Actin-like ATPase domain | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| Aldolase | 0 | Direct |
| Cystatin/monellin | 0 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
| GAS2 domain-like | 0 | Direct |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
| JAB1/MPN domain | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| Chaperone J-domain | 0 | Direct |
| SPOC domain-like | 0 | Direct |
| ADP-ribosylation | 0 | Direct |
| Complement control module/SCR domain | 0 | Direct |
| MgtE membrane domain-like | 0 | Direct |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Thiolase-like | 0 | Direct |
| Glutathione synthetase ATP-binding domain-like | 0 | Direct |
| Ribosomal protein S18 | 0 | Direct |
| eIF4e-like | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| Retrovirus zinc finger-like domains | 0 | Direct |
| PK beta-barrel domain-like | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | Direct |
| Second domain of FERM | 0 | Direct |
| GAT-like domain | 0 | Direct |
| PIN domain-like | 0 | Direct |
| Diaminopimelate epimerase-like | 0 | Direct |
| Pepsin inhibitor-3 | 0 | Direct |
| Chitinase insertion domain | 0 | Direct |
| Aquaporin-like | 0 | Direct |
| ArfGap/RecO-like zinc finger | 0 | Direct |
| Doublecortin (DC) | 0 | Direct |
| Purine and uridine phosphorylases | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| Surp module (SWAP domain) | 0 | Direct |
| PurM C-terminal domain-like | 0 | Direct |
| Tubulin C-terminal domain-like | 0 | Direct |
| HSP20-like chaperones | 0 | Direct |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
| Molybdenum cofactor biosynthesis proteins | 0 | Direct |
| Nop domain | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| CAD & PB1 domains | 0 | Direct |
| Cullin repeat-like | 0 | Direct |
| alpha-catenin/vinculin-like | 0 | Direct |
| Tricorn protease domain 2 | 0 | Direct |
| MFPT repeat-like | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Mitochondrial carrier | 0 | Direct |
| HCP-like | 0 | Direct |
| t-snare proteins | 0 | Direct |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| GroEL equatorial domain-like | 0 | Direct |
| FF domain | 0 | Direct |
| ACP-like | 0 | Direct |
| GYF domain | 0 | Direct |
| Nucleoside diphosphate kinase, NDK | 0 | Direct |
| HRDC-like | 0 | Direct |
| ENTH/VHS domain | 0 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| Carboxypeptidase regulatory domain-like | 0 | Direct |
| cAMP-binding domain-like | 0 | Direct |
| Single hybrid motif | 0 | Direct |
| Carbon-nitrogen hydrolase | 0 | Direct |
| PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | Direct |
| Galactose oxidase, central domain | 0 | Direct |
| beta-lactamase/transpeptidase-like | 0 | Direct |
| ThrRS/AlaRS common domain | 0 | Direct |
| Invertebrate chitin-binding proteins | 0 | Direct |
| Ribosomal L27 protein-like | 0 | Direct |
| CBD9-like | 0 | Direct |
| Galactose mutarotase-like | 0 | Direct |
| Tim10-like | 0 | Direct |
| SCP-like | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| Transducin (alpha subunit), insertion domain | 0 | Direct |
| Ribosomal protein S10 | 0 | Direct |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | Direct |
| Elafin-like | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
| Zn-binding ribosomal proteins | 0 | Direct |
| Skp1 dimerisation domain-like | 0 | Direct |
| Cadherin-like | 0 | Direct |
| Terpenoid synthases | 0 | Direct |
| Radical SAM enzymes | 0 | Direct |
| Cdc48 domain 2-like | 0 | Direct |
| Protease propeptides/inhibitors | 0 | Direct |
| Band 7/SPFH domain | 0 | Direct |
| GroEL apical domain-like | 0 | Direct |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
| Spectrin repeat | 0 | Direct |
| Creatinase/prolidase N-terminal domain | 0 | Direct |
| S-adenosylmethionine synthetase | 0 | Direct |
| SAND domain-like | 0 | Direct |
| Sec7 domain | 0 | Direct |
| NagB/RpiA/CoA transferase-like | 0 | Direct |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
| Subtilisin-like | 0 | Direct |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | Direct |
| Hormone receptor domain | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| Heme-dependent peroxidases | 0 | Direct |
| PLC-like phosphodiesterases | 0 | Direct |
| TGS-like | 0 | Direct |
| PAP/OAS1 substrate-binding domain | 0 | Direct |
| PUA domain-like | 0 | Direct |
| L30e-like | 0 | Direct |
| Hedgehog/intein (Hint) domain | 0 | Direct |
| PHM/PNGase F | 0 | Direct |
| PABC (PABP) domain | 0 | Direct |
| MOSC N-terminal domain-like | 0 | Direct |
| ISP domain | 0 | Direct |
| Rap/Ran-GAP | 0 | Direct |
| RBP11-like subunits of RNA polymerase | 0 | Direct |
| Clc chloride channel | 0 | Direct |
| alpha/beta knot | 0 | Direct |
| PreATP-grasp domain | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| Sec63 N-terminal domain-like | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Molybdenum cofactor-binding domain | 0 | Direct |
| Carbohydrate phosphatase | 0 | Direct |
| CRAL/TRIO N-terminal domain | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| Hypothetical protein c14orf129, hspc210 | 0 | Direct |
| AN1-like Zinc finger | 0 | Direct |
| Activating enzymes of the ubiquitin-like proteins | 0 | Direct |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | Direct |
| Profilin (actin-binding protein) | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Histone-fold | 0 | Direct |
| Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
| FAD-linked oxidases, C-terminal domain | 0 | Direct |
| ARID-like | 0 | Direct |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| Ribosomal proteins S24e, L23 and L15e | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Cation efflux protein cytoplasmic domain-like | 0 | Direct |
| Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
| Composite domain of metallo-dependent hydrolases | 0 | Direct |
| Class II aaRS ABD-related | 0 | Direct |
| Acyl-CoA dehydrogenase NM domain-like | 0 | Direct |
| R3H domain | 0 | Direct |
| Small-conductance potassium channel | 0 | Direct |
| Restriction endonuclease-like | 0 | Direct |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Nucleoporin domain | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| 2Fe-2S ferredoxin-like | 0 | Direct |
| WGR domain-like | 0 | Direct |
| Fibrinogen C-terminal domain-like | 0 | Direct |
| MIR domain | 0 | Direct |
| L-aspartase-like | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Oxysterol-binding protein-like | 0 | Direct |
| Polo-box domain | 0 | Direct |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | Direct |
| YbiA-like | 0 | Direct |
| FAD-binding/transporter-associated domain-like | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| Chromo domain-like | 0 | Direct |
| Ribokinase-like | 0 | Direct |
| Heme-dependent catalase-like | 0 | Direct |
| Ribosomal protein L1 | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| Periplasmic binding protein-like II | 0 | Direct |
| SIS domain | 0 | Direct |
| Ran binding protein zinc finger-like | 0 | Direct |
| Integrin alpha N-terminal domain | 0 | Direct |
| PEP carboxykinase-like | 0 | Direct |
| DNA repair protein MutS, domain III | 0 | Direct |
| Blood coagulation inhibitor (disintegrin) | 0 | Direct |
| Acetyl-CoA synthetase-like | 0 | Direct |
| VPS9 domain | 0 | Direct |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0 | Direct |
| Outer arm dynein light chain 1 | 0 | Direct |
| BEACH domain | 0 | Direct |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | Direct |
| PGBD-like | 0 | Direct |
| LDH C-terminal domain-like | 0 | Direct |
| lambda repressor-like DNA-binding domains | 0 | Direct |
| LysM domain | 0 | Direct |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | Direct |
| HSP40/DnaJ peptide-binding domain | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| Arginase/deacetylase | 0 | Direct |
| YWTD domain | 0 | Direct |
| P-loop containing nucleoside triphosphate hydrolases | 0.0000003335 | Direct |
| PH domain-like | 0.0000176 | Direct |
| PapD-like | 0.007762 | Inherited |
| PDZ domain-like | 0.007917 | Inherited |
| TPR-like | 0.01127 | Inherited |
| Periplasmic binding protein-like I | 0.01257 | Inherited |
| ABC transporter transmembrane region | 0.01777 | Inherited |
| ARM repeat | 0.01833 | Inherited |
| Protein kinase-like (PK-like) | 0.03384 | Inherited |
| SH3-domain | 0.04295 | Inherited |
| Nucleic acid-binding proteins | 0.04295 | Inherited |
| Homeodomain-like | 0.04914 | Inherited |
| WD40 repeat-like | 0.05855 | Inherited |
| CCCH zinc finger | 0.06257 | Inherited |
| FYVE/PHD zinc finger | 0.0717 | Inherited |
| Translation proteins | 0.07824 | Inherited |
| "Winged helix" DNA-binding domain | 0.0889 | Inherited |
| Nucleotide cyclase | 0.09226 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.09226 | Inherited |
| SMAD/FHA domain | 0.09799 | Inherited |
| Calcium ATPase, transmembrane domain M | 0.1096 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1226 | Inherited |
| Regulator of G-protein signaling, RGS | 0.1226 | Inherited |
| EGF/Laminin | 0.1279 | Inherited |
| Acid proteases | 0.1367 | Inherited |
| Calcium ATPase, transduction domain A | 0.1367 | Inherited |
| Cysteine-rich domain | 0.1451 | Inherited |
| Quinoprotein alcohol dehydrogenase-like | 0.1529 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.1585 | Inherited |
| HMG-box | 0.1707 | Inherited |
| DBL homology domain (DH-domain) | 0.1707 | Inherited |
| ClpP/crotonase | 0.1707 | Inherited |
| Cytochrome P450 | 0.1734 | Inherited |
| (Trans)glycosidases | 0.1836 | Inherited |
| Ankyrin repeat | 0.199 | Inherited |
| Cyclin-like | 0.2234 | Inherited |
| Cysteine proteinases | 0.2338 | Inherited |
| Bromodomain | 0.2365 | Inherited |
| Tudor/PWWP/MBT | 0.2365 | Inherited |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.2365 | Inherited |
| POZ domain | 0.2544 | Inherited |
| SNARE-like | 0.2638 | Inherited |
| Lipocalins | 0.264 | Inherited |
| Metallo-dependent phosphatases | 0.2696 | Inherited |
| RNA-binding domain, RBD | 0.2851 | Inherited |
| DNA/RNA polymerases | 0.294 | Inherited |
| PX domain | 0.3269 | Inherited |
| Translation proteins SH3-like domain | 0.3269 | Inherited |
| Cation efflux protein transmembrane domain-like | 0.3269 | Inherited |
| HAD-like | 0.3502 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.3658 | Inherited |
| PLP-dependent transferases | 0.3721 | Inherited |
| Ubiquitin-like | 0.3821 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.402 | Inherited |
| HD-domain/PDEase-like | 0.4026 | Inherited |
| FKBP-like | 0.4026 | Inherited |
| RNI-like | 0.405 | Inherited |
| Class II aaRS and biotin synthetases | 0.4203 | Inherited |
| DHS-like NAD/FAD-binding domain | 0.4474 | Inherited |
| Myosin rod fragments | 0.4474 | Inherited |
| PRTase-like | 0.4474 | Inherited |
| Hect, E3 ligase catalytic domain | 0.4474 | Inherited |
| Galactose-binding domain-like | 0.4806 | Inherited |
| Ribosomal protein S5 domain 2-like | 0.4806 | Inherited |
| Sm-like ribonucleoproteins | 0.4836 | Inherited |
| Cystine-knot cytokines | 0.4836 | Inherited |
| SH2 domain | 0.4928 | Inherited |
| Calpain large subunit, middle domain (domain III) | 0.4934 | Inherited |
| Riboflavin synthase domain-like | 0.4934 | Inherited |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.4934 | Inherited |
| Zinc beta-ribbon | 0.4934 | Inherited |
| FAD/NAD(P)-binding domain | 0.5099 | Inherited |
| WW domain | 0.52 | Inherited |
| FAD-linked reductases, C-terminal domain | 0.52 | Inherited |
| Voltage-gated potassium channels | 0.5279 | Inherited |
| SAM/Pointed domain | 0.5289 | Inherited |
| Nucleotidylyl transferase | 0.5289 | Inherited |
| SET domain | 0.5324 | Inherited |
| UBC-like | 0.5324 | Inherited |
| Seven-hairpin glycosidases | 0.5481 | Inherited |
| Multidrug resistance efflux transporter EmrE | 0.5551 | Inherited |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.5927 | Inherited |
| Di-copper centre-containing domain | 0.6034 | Inherited |
| Nucleotide-binding domain | 0.6034 | Inherited |
| KA1-like | 0.6034 | Inherited |
| HIT/MYND zinc finger-like | 0.6318 | Inherited |
| S-adenosyl-L-methionine-dependent methyltransferases | 0.641 | Inherited |
| MFS general substrate transporter | 0.6418 | Inherited |
| S15/NS1 RNA-binding domain | 0.6688 | Inherited |
| 4Fe-4S ferredoxins | 0.6688 | Inherited |
| Frizzled cysteine-rich domain | 0.6688 | Inherited |
| DNase I-like | 0.6727 | Inherited |
| GST C-terminal domain-like | 0.6824 | Inherited |
| MIT domain | 0.7394 | Inherited |
| ADC-like | 0.7394 | Inherited |
| Fibronectin type III | 0.7435 | Inherited |
| alpha/beta-Hydrolases | 0.7453 | Inherited |
| EF-hand | 0.7469 | Inherited |
| Clavaminate synthase-like | 0.7957 | Inherited |
| NAD kinase/diacylglycerol kinase-like | 0.7985 | Inherited |
| Ribonuclease H-like | 0.7985 | Inherited |
| Cyclophilin-like | 0.8089 | Inherited |
| CoA-dependent acyltransferases | 0.8089 | Inherited |
| UBA-like | 0.8205 | Inherited |
| SNF-like | 0.8404 | Inherited |
| Leucine zipper domain | 0.8473 | Inherited |
| Eukaryotic type KH-domain (KH-domain type I) | 0.8567 | Inherited |
| GTPase activation domain, GAP | 0.8567 | Inherited |
| Thioredoxin-like | 0.8913 | Inherited |
| p53-like transcription factors | 0.8962 | Inherited |
| Immunoglobulin | 0.9033 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.9054 | Inherited |
| Ribonuclease PH domain 2-like | 0.9222 | Inherited |
| Nucleotide-diphospho-sugar transferases | 0.9267 | Inherited |
| Saposin | 0.9491 | Inherited |
| PAZ domain | 0.9843 | Inherited |
| Ligand-binding domain in the NO signalling and Golgi transport | 0.9938 | Inherited |
| beta-beta-alpha zinc fingers | 1 | Inherited |
| B-box zinc-binding domain | 1 | Inherited |
| Nuclear receptor ligand-binding domain | 1 | Inherited |
| Bet v1-like | 1 | Inherited |
| RING/U-box | 1 | Inherited |
| Family A G protein-coupled receptor-like | 1 | Inherited |
| Snake toxin-like | 1 | Inherited |
| F-box domain | 1 | Inherited |
(show details)
Supra-domains annotated to this WP term (Not in SPWP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57903,82199
57903 - FYVE/PHD zinc finger
82199 - SET domain | 0 | DIRECT |
51905,56425
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
56672,100879
56672 - DNA/RNA polymerases
100879 - Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
51735,56327
51735 - NAD(P)-binding Rossmann-fold domains
56327 - LDH C-terminal domain-like | 0 | DIRECT |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | DIRECT |
57414,57414
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like | 0 | DIRECT |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
56601,48403
56601 - beta-lactamase/transpeptidase-like
48403 - Ankyrin repeat | 0 | DIRECT |
56112,82615
56112 - Protein kinase-like (PK-like)
82615 - Polo-box domain | 0 | DIRECT |
161093,161093
161093 - MgtE membrane domain-like
161093 - MgtE membrane domain-like | 0 | DIRECT |
49493,49493
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
48464,89009
48464 - ENTH/VHS domain
89009 - GAT-like domain | 0 | DIRECT |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
81333,81333
81333 - F1F0 ATP synthase subunit C
81333 - F1F0 ATP synthase subunit C | 0 | DIRECT |
56968,48431
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
52540,81271
52540 - P-loop containing nucleoside triphosphate hydrolases
81271 - TGS-like | 0 | DIRECT |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | DIRECT |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | DIRECT |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | DIRECT |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
81324,81296
81324 - Voltage-gated potassium channels
81296 - E set domains | 0 | DIRECT |
52540,140990
52540 - P-loop containing nucleoside triphosphate hydrolases
140990 - FtsH protease domain-like | 0 | DIRECT |
47203,47203
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
52113,52113
52113 - BRCT domain
52113 - BRCT domain | 0 | DIRECT |
81698,81698
81698 - FF domain
81698 - FF domain | 0 | DIRECT |
56112,48371
56112 - Protein kinase-like (PK-like)
48371 - ARM repeat | 0 | DIRECT |
51556,51338
51556 - Metallo-dependent hydrolases
51338 - Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | DIRECT |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
81383,52047
81383 - F-box domain
52047 - RNI-like | 0 | DIRECT |
55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | DIRECT |
54695,81382
54695 - POZ domain
81382 - Skp1 dimerisation domain-like | 0 | DIRECT |
52283,51735
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
53187,49464
53187 - Zn-dependent exopeptidases
49464 - Carboxypeptidase regulatory domain-like | 0 | DIRECT |
81383,50978
81383 - F-box domain
50978 - WD40 repeat-like | 0 | DIRECT |
52440,56059
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
55729,55729
55729 - Acyl-CoA N-acyltransferases (Nat)
55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | DIRECT |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | DIRECT |
50044,52540
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
144232,82199
144232 - HIT/MYND zinc finger-like
82199 - SET domain | 0 | DIRECT |
54236,54236
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0 | DIRECT |
54292,47741
54292 - 2Fe-2S ferredoxin-like
47741 - CO dehydrogenase ISP C-domain like | 0 | DIRECT |
81324,53850
81324 - Voltage-gated potassium channels
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0 | DIRECT |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
54897,53187
54897 - Protease propeptides/inhibitors
53187 - Zn-dependent exopeptidases | 0 | DIRECT |
57938,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0 | DIRECT |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0 | DIRECT |
51971,54373
51971 - Nucleotide-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0 | DIRECT |
47576,47576
47576 - Calponin-homology domain, CH-domain
47576 - Calponin-homology domain, CH-domain | 0 | DIRECT |
51338,51556
51338 - Composite domain of metallo-dependent hydrolases
51556 - Metallo-dependent hydrolases | 0 | DIRECT |
52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
52047,52047
52047 - RNI-like
52047 - RNI-like | 0 | DIRECT |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0 | DIRECT |
47741,56176
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like | 0 | DIRECT |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
81301,81631
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain | 0 | DIRECT |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0 | DIRECT |
46785,46785
46785 - "Winged helix" DNA-binding domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0 | DIRECT |
56176,55103
56176 - FAD-binding/transporter-associated domain-like
55103 - FAD-linked oxidases, C-terminal domain | 0 | DIRECT |
48403,52151
48403 - Ankyrin repeat
52151 - FabD/lysophospholipase-like | 0 | DIRECT |
56059,52210
56059 - Glutathione synthetase ATP-binding domain-like
52210 - Succinyl-CoA synthetase domains | 0 | DIRECT |
50044,50044
50044 - SH3-domain
50044 - SH3-domain | 0 | DIRECT |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0 | DIRECT |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | DIRECT |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | DIRECT |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
57889,48350
57889 - Cysteine-rich domain
48350 - GTPase activation domain, GAP | 0 | DIRECT |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
100950,100950
100950 - NagB/RpiA/CoA transferase-like
100950 - NagB/RpiA/CoA transferase-like | 0 | DIRECT |
51445,54556
51445 - (Trans)glycosidases
54556 - Chitinase insertion domain | 0 | DIRECT |
49742,49742
49742 - PHM/PNGase F
49742 - PHM/PNGase F | 0 | DIRECT |
46938,52087
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain | 0 | DIRECT |
57756,57756
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains | 0 | DIRECT |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0 | DIRECT |
53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | DIRECT |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0 | DIRECT |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
48179,48179
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
82615,82615
82615 - Polo-box domain
82615 - Polo-box domain | 0 | DIRECT |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | DIRECT |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | DIRECT |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | DIRECT |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
161111,160240
161111 - Cation efflux protein transmembrane domain-like
160240 - Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
53738,55957
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0 | DIRECT |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
53901,53901
53901 - Thiolase-like
53901 - Thiolase-like | 0 | DIRECT |
50156,50044
50156 - PDZ domain-like
50044 - SH3-domain | 0 | DIRECT |
88713,88688
88713 - Glycoside hydrolase/deacetylase
88688 - Families 57/38 glycoside transferase middle domain | 0 | DIRECT |
55326,56042
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like | 0 | DIRECT |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | DIRECT |
141739,141739
141739 - MFPT repeat-like
141739 - MFPT repeat-like | 0 | DIRECT |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | DIRECT |
57625,57625
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins | 0 | DIRECT |
55394,55394
55394 - Bactericidal permeability-increasing protein, BPI
55394 - Bactericidal permeability-increasing protein, BPI | 0 | DIRECT |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0 | DIRECT |
57850,117839
57850 - RING/U-box
117839 - WWE domain | 0 | DIRECT |
81324,81327
81324 - Voltage-gated potassium channels
81327 - Small-conductance potassium channel | 0 | DIRECT |
50978,50998
50978 - WD40 repeat-like
50998 - Quinoprotein alcohol dehydrogenase-like | 0 | DIRECT |
57196,63825
57196 - EGF/Laminin
63825 - YWTD domain | 0 | DIRECT |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | DIRECT |
54211,55060
54211 - Ribosomal protein S5 domain 2-like
55060 - GHMP Kinase, C-terminal domain | 0 | DIRECT |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | DIRECT |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | DIRECT |
68923,53795
68923 - PEP carboxykinase N-terminal domain
53795 - PEP carboxykinase-like | 0 | DIRECT |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
54665,56003
54665 - CO dehydrogenase molybdoprotein N-domain-like
56003 - Molybdenum cofactor-binding domain | 0 | DIRECT |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
81631,55003
81631 - PAP/OAS1 substrate-binding domain
55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | DIRECT |
54495,46934
54495 - UBC-like
46934 - UBA-like | 0 | DIRECT |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0 | DIRECT |
74650,51445
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases | 0 | DIRECT |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | DIRECT |
48425,50729
48425 - Sec7 domain
50729 - PH domain-like | 0 | DIRECT |
51735,55347
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | DIRECT |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0 | DIRECT |
57863,48403
57863 - ArfGap/RecO-like zinc finger
48403 - Ankyrin repeat | 0 | DIRECT |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | DIRECT |
57362,57362
57362 - BPTI-like
57362 - BPTI-like | 0 | DIRECT |
141673,50800
141673 - MOSC N-terminal domain-like
50800 - PK beta-barrel domain-like | 0 | DIRECT |
47587,56399
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | DIRECT |
47473,103506
47473 - EF-hand
103506 - Mitochondrial carrier | 0 | DIRECT |
64356,49447
64356 - SNARE-like
49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
51445,51011
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0 | DIRECT |
57889,50729
57889 - Cysteine-rich domain
50729 - PH domain-like | 0 | DIRECT |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | DIRECT |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0 | DIRECT |
48431,56968
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | DIRECT |
55920,46785
55920 - Creatinase/aminopeptidase
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
52540,90123
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0 | DIRECT |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0 | DIRECT |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | DIRECT |
53187,55031
53187 - Zn-dependent exopeptidases
55031 - Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0 | DIRECT |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | DIRECT |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | DIRECT |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.01777 | INHERITED FROM: chemical hypersensitive || cadmium hypersensitive || metal response variant || cadmium response variant || RNAi resistant || RNAi response variant || chemical response variant || colchicine hypersensitive |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.09799 | INHERITED FROM: organism temperature response variant || ivermectin response variant || dauer defective || aldicarb response variant || antihelmintic response variant || positive chemotaxis defective || aqueous chemosensory response variant || pattern of transgene expression variant || ivermectin resistant || chemotaxis variant || gene expression variant |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1169 | INHERITED FROM: organism UV response variant || organism environmental stimulus response variant || sick || organism stress response variant |
56112,55073
56112 - Protein kinase-like (PK-like)
55073 - Nucleotide cyclase | 0.1226 | INHERITED FROM: magnesium chemotaxis defective || chemosensory response variant || AWC odorant chemotaxis defective || cation positive chemotaxis variant || AWC odorant chemotaxis variant || positive chemotaxis variant || alkaline pH chemotaxis variant || aqueous chemosensory response variant || bromide chemotaxis variant || iodide chemotaxis defective || chemical response variant || bromide chemotaxis defective || chemotaxis variant || anion positive chemotaxis defective || anion positive chemotaxis variant || cation positive chemotaxis defective || lithium chemotaxis defective || iodide chemotaxis variant || benzaldehyde chemotaxis variant |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0.1226 | INHERITED FROM: lipid composition variant || drug hypersensitive || nicotine hypersensitive |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0.1336 | INHERITED FROM: cadmium hypersensitive || cadmium response variant |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0.1904 | INHERITED FROM: protein protein interaction variant || transgene expression variant || proteasome core activity variant || mRNA levels increased || mRNA levels reduced || protein phosphorylation variant || protein aggregation variant || protein phosphorylation increased |
56436,49854
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain | 0.2234 | INHERITED FROM: cadmium hypersensitive || cadmium response variant |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.2365 | INHERITED FROM: lipid metabolism variant || fat content variant |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.2365 | INHERITED FROM: drug hypersensitive || organism environmental stimulus response variant || nicotine hypersensitive |
50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0.294 | INHERITED FROM: odorant chemosensory response variant || ivermectin response variant || chemical resistant || drug resistant || dauer formation variant || dauer defective || aqueous positive chemotaxis variant || aqueous positive chemotaxis defective || osmotic avoidance variant || pesticide response variant || positive chemotaxis defective || positive chemotaxis variant || aqueous chemosensory response variant || negative chemotaxis variant || ivermectin resistant || chemotaxis variant || dauer development variant || mechanosensation variant |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.294 | INHERITED FROM: protein protein interaction variant || protein interaction variant || pattern of transgene expression variant || protein aggregation variant |
47473,47473
47473 - EF-hand
47473 - EF-hand | 0.3269 | INHERITED FROM: acetylcholinesterase inhibitor response variant || aldicarb response variant || drug response variant |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.3903 | INHERITED FROM: starvation induced apoptosis variant || organism starvation response variant || organism metabolism processing variant || late larval arrest || gene expression variant |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.402 | INHERITED FROM: cholinergic agonist resistant || chemosensory response variant || chemical resistant || AWC odorant chemotaxis variant || hypoosmotic shock hypersensitive || nicotine resistant || DMPP resistant || organism environmental stimulus response variant || antihelmintic response variant || positive chemotaxis variant || DMPP response variant || thermotaxis variant || thermosensory behavior variant || selenium response variant || chemical response variant || slowing response on food variant || mechanosensation variant || drug response variant || sodium chloride chemotaxis variant || benzaldehyde chemotaxis variant |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.4527 | INHERITED FROM: organism metabolism processing variant || protein expression variant || protein expression reduced |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.5125 | INHERITED FROM: organism electrophilic stress hypersensitive || paraquat response variant || cadmium hypersensitive || metal response variant || organism environmental stimulus response variant || organism heat hypersensitive || organism stress response variant || enzyme activity reduced || enzyme activity variant |
101690,53098
101690 - PAZ domain
53098 - Ribonuclease H-like | 0.5481 | INHERITED FROM: RNA expression variant || 21U RNA expression variant || maintenance of gene silencing variant || RNAi response variant || gene expression variant |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.5481 | INHERITED FROM: protein expression reduced |
90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0.5481 | INHERITED FROM: hermaphrodite physiology variant || sexually dimorphic physiology variant |
51045,51045
51045 - WW domain
51045 - WW domain | 0.6034 | INHERITED FROM: transgene expression variant |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0.6688 | INHERITED FROM: organism UV response variant || organism UV hypersensitive || organism stress response variant |
50249,55681
50249 - Nucleic acid-binding proteins
55681 - Class II aaRS and biotin synthetases | 0.6688 | INHERITED FROM: avoids bacterial lawn || transgene expression increased || response to bacteria variant |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0.6727 | INHERITED FROM: shortened life span || life span variant |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.6884 | INHERITED FROM: protein expression reduced |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0.7394 | INHERITED FROM: protein expression variant || level of protein expression variant || protein expression reduced |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.7786 | INHERITED FROM: SDS sensitive dauer || dauer resistance to harsh conditions variant |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.8089 | INHERITED FROM: protein degradation variant || growth rate variant |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.8454 | INHERITED FROM: protein degradation variant || growth rate variant |
54211,55666
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like | 0.9222 | INHERITED FROM: early larval arrest |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.9265 | INHERITED FROM: chemical resistant || drug resistant |
49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0.9511 | INHERITED FROM: protein protein interaction variant || protein interaction variant || protein aggregation variant |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0.9511 | INHERITED FROM: lipid metabolism variant || fat content variant || dauer development variant |
53300,56436
53300 - vWA-like
56436 - C-type lectin-like | 1 | INHERITED FROM: pathogen susceptibility increased || pathogen induced death increased |
57850,57850
57850 - RING/U-box
57850 - RING/U-box | 1 | INHERITED FROM: protein protein interaction variant || protein interaction variant || transgene subcellular localization variant || protein aggregation variant |
57850,57845
57850 - RING/U-box
57845 - B-box zinc-binding domain | 1 | INHERITED FROM: protein protein interaction variant || protein interaction variant || transgene subcellular localization variant || protein aggregation variant |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57903,82199
57903 - FYVE/PHD zinc finger
82199 - SET domain | 0 | Direct |
51905,56425
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
56672,100879
56672 - DNA/RNA polymerases
100879 - Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | Direct |
51735,56327
51735 - NAD(P)-binding Rossmann-fold domains
56327 - LDH C-terminal domain-like | 0 | Direct |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | Direct |
57414,57414
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like | 0 | Direct |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
56601,48403
56601 - beta-lactamase/transpeptidase-like
48403 - Ankyrin repeat | 0 | Direct |
56112,82615
56112 - Protein kinase-like (PK-like)
82615 - Polo-box domain | 0 | Direct |
161093,161093
161093 - MgtE membrane domain-like
161093 - MgtE membrane domain-like | 0 | Direct |
49493,49493
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
48464,89009
48464 - ENTH/VHS domain
89009 - GAT-like domain | 0 | Direct |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
81333,81333
81333 - F1F0 ATP synthase subunit C
81333 - F1F0 ATP synthase subunit C | 0 | Direct |
56968,48431
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
52540,81271
52540 - P-loop containing nucleoside triphosphate hydrolases
81271 - TGS-like | 0 | Direct |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | Direct |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | Direct |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | Direct |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0 | Direct |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0 | Direct |
81324,81296
81324 - Voltage-gated potassium channels
81296 - E set domains | 0 | Direct |
52540,140990
52540 - P-loop containing nucleoside triphosphate hydrolases
140990 - FtsH protease domain-like | 0 | Direct |
47203,47203
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
52113,52113
52113 - BRCT domain
52113 - BRCT domain | 0 | Direct |
81698,81698
81698 - FF domain
81698 - FF domain | 0 | Direct |
56112,48371
56112 - Protein kinase-like (PK-like)
48371 - ARM repeat | 0 | Direct |
51556,51338
51556 - Metallo-dependent hydrolases
51338 - Composite domain of metallo-dependent hydrolases | 0 | Direct |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | Direct |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
81383,52047
81383 - F-box domain
52047 - RNI-like | 0 | Direct |
55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | Direct |
54695,81382
54695 - POZ domain
81382 - Skp1 dimerisation domain-like | 0 | Direct |
52283,51735
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
53187,49464
53187 - Zn-dependent exopeptidases
49464 - Carboxypeptidase regulatory domain-like | 0 | Direct |
81383,50978
81383 - F-box domain
50978 - WD40 repeat-like | 0 | Direct |
52440,56059
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 0 | Direct |
55729,55729
55729 - Acyl-CoA N-acyltransferases (Nat)
55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | Direct |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | Direct |
50044,52540
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
144232,82199
144232 - HIT/MYND zinc finger-like
82199 - SET domain | 0 | Direct |
54236,54236
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0 | Direct |
54292,47741
54292 - 2Fe-2S ferredoxin-like
47741 - CO dehydrogenase ISP C-domain like | 0 | Direct |
81324,53850
81324 - Voltage-gated potassium channels
53850 - Periplasmic binding protein-like II | 0 | Direct |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0 | Direct |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
54897,53187
54897 - Protease propeptides/inhibitors
53187 - Zn-dependent exopeptidases | 0 | Direct |
57938,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0 | Direct |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0 | Direct |
51971,54373
51971 - Nucleotide-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0 | Direct |
47576,47576
47576 - Calponin-homology domain, CH-domain
47576 - Calponin-homology domain, CH-domain | 0 | Direct |
51338,51556
51338 - Composite domain of metallo-dependent hydrolases
51556 - Metallo-dependent hydrolases | 0 | Direct |
52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
52047,52047
52047 - RNI-like
52047 - RNI-like | 0 | Direct |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0 | Direct |
47741,56176
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like | 0 | Direct |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | Direct |
81301,81631
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain | 0 | Direct |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0 | Direct |
46785,46785
46785 - "Winged helix" DNA-binding domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0 | Direct |
56176,55103
56176 - FAD-binding/transporter-associated domain-like
55103 - FAD-linked oxidases, C-terminal domain | 0 | Direct |
48403,52151
48403 - Ankyrin repeat
52151 - FabD/lysophospholipase-like | 0 | Direct |
56059,52210
56059 - Glutathione synthetase ATP-binding domain-like
52210 - Succinyl-CoA synthetase domains | 0 | Direct |
50044,50044
50044 - SH3-domain
50044 - SH3-domain | 0 | Direct |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0 | Direct |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | Direct |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | Direct |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
57889,48350
57889 - Cysteine-rich domain
48350 - GTPase activation domain, GAP | 0 | Direct |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
100950,100950
100950 - NagB/RpiA/CoA transferase-like
100950 - NagB/RpiA/CoA transferase-like | 0 | Direct |
51445,54556
51445 - (Trans)glycosidases
54556 - Chitinase insertion domain | 0 | Direct |
49742,49742
49742 - PHM/PNGase F
49742 - PHM/PNGase F | 0 | Direct |
46938,52087
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain | 0 | Direct |
57756,57756
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains | 0 | Direct |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0 | Direct |
53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | Direct |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0 | Direct |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0 | Direct |
48179,48179
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
82615,82615
82615 - Polo-box domain
82615 - Polo-box domain | 0 | Direct |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | Direct |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | Direct |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | Direct |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | Direct |
161111,160240
161111 - Cation efflux protein transmembrane domain-like
160240 - Cation efflux protein cytoplasmic domain-like | 0 | Direct |
53738,55957
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | Direct |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0 | Direct |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
53901,53901
53901 - Thiolase-like
53901 - Thiolase-like | 0 | Direct |
50156,50044
50156 - PDZ domain-like
50044 - SH3-domain | 0 | Direct |
88713,88688
88713 - Glycoside hydrolase/deacetylase
88688 - Families 57/38 glycoside transferase middle domain | 0 | Direct |
55326,56042
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like | 0 | Direct |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | Direct |
141739,141739
141739 - MFPT repeat-like
141739 - MFPT repeat-like | 0 | Direct |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | Direct |
57625,57625
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins | 0 | Direct |
55394,55394
55394 - Bactericidal permeability-increasing protein, BPI
55394 - Bactericidal permeability-increasing protein, BPI | 0 | Direct |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0 | Direct |
57850,117839
57850 - RING/U-box
117839 - WWE domain | 0 | Direct |
81324,81327
81324 - Voltage-gated potassium channels
81327 - Small-conductance potassium channel | 0 | Direct |
50978,50998
50978 - WD40 repeat-like
50998 - Quinoprotein alcohol dehydrogenase-like | 0 | Direct |
57196,63825
57196 - EGF/Laminin
63825 - YWTD domain | 0 | Direct |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | Direct |
54211,55060
54211 - Ribosomal protein S5 domain 2-like
55060 - GHMP Kinase, C-terminal domain | 0 | Direct |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | Direct |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | Direct |
68923,53795
68923 - PEP carboxykinase N-terminal domain
53795 - PEP carboxykinase-like | 0 | Direct |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
54665,56003
54665 - CO dehydrogenase molybdoprotein N-domain-like
56003 - Molybdenum cofactor-binding domain | 0 | Direct |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | Direct |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | Direct |
81631,55003
81631 - PAP/OAS1 substrate-binding domain
55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | Direct |
54495,46934
54495 - UBC-like
46934 - UBA-like | 0 | Direct |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0 | Direct |
74650,51445
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases | 0 | Direct |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | Direct |
48425,50729
48425 - Sec7 domain
50729 - PH domain-like | 0 | Direct |
51735,55347
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | Direct |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0 | Direct |
57863,48403
57863 - ArfGap/RecO-like zinc finger
48403 - Ankyrin repeat | 0 | Direct |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | Direct |
57362,57362
57362 - BPTI-like
57362 - BPTI-like | 0 | Direct |
141673,50800
141673 - MOSC N-terminal domain-like
50800 - PK beta-barrel domain-like | 0 | Direct |
47587,56399
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | Direct |
47473,103506
47473 - EF-hand
103506 - Mitochondrial carrier | 0 | Direct |
64356,49447
64356 - SNARE-like
49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
51445,51011
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0 | Direct |
57889,50729
57889 - Cysteine-rich domain
50729 - PH domain-like | 0 | Direct |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | Direct |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0 | Direct |
48431,56968
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | Direct |
55920,46785
55920 - Creatinase/aminopeptidase
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
52540,90123
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0 | Direct |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0 | Direct |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | Direct |
53187,55031
53187 - Zn-dependent exopeptidases
55031 - Bacterial exopeptidase dimerisation domain | 0 | Direct |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0 | Direct |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | Direct |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | Direct |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.01777 | Inherited |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.09799 | Inherited |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1169 | Inherited |
56112,55073
56112 - Protein kinase-like (PK-like)
55073 - Nucleotide cyclase | 0.1226 | Inherited |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0.1226 | Inherited |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0.1336 | Inherited |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0.1904 | Inherited |
56436,49854
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain | 0.2234 | Inherited |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.2365 | Inherited |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.2365 | Inherited |
50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0.294 | Inherited |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.294 | Inherited |
47473,47473
47473 - EF-hand
47473 - EF-hand | 0.3269 | Inherited |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.3903 | Inherited |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.402 | Inherited |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.4527 | Inherited |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.5125 | Inherited |
101690,53098
101690 - PAZ domain
53098 - Ribonuclease H-like | 0.5481 | Inherited |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.5481 | Inherited |
90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0.5481 | Inherited |
51045,51045
51045 - WW domain
51045 - WW domain | 0.6034 | Inherited |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0.6688 | Inherited |
50249,55681
50249 - Nucleic acid-binding proteins
55681 - Class II aaRS and biotin synthetases | 0.6688 | Inherited |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0.6727 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.6884 | Inherited |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0.7394 | Inherited |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.7786 | Inherited |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.8089 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.8454 | Inherited |
54211,55666
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like | 0.9222 | Inherited |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.9265 | Inherited |
49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0.9511 | Inherited |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0.9511 | Inherited |
53300,56436
53300 - vWA-like
56436 - C-type lectin-like | 1 | Inherited |
57850,57850
57850 - RING/U-box
57850 - RING/U-box | 1 | Inherited |
57850,57845
57850 - RING/U-box
57845 - B-box zinc-binding domain | 1 | Inherited |
(show details)
Supra-domains annotated to this WP term (Not in SPWP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
81301,81631,55003
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain
55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | DIRECT |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | DIRECT |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
53738,53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | DIRECT |
52540,90123,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
50044,50044,50044
50044 - SH3-domain
50044 - SH3-domain
50044 - SH3-domain | 0 | DIRECT |
57362,57362,57362
57362 - BPTI-like
57362 - BPTI-like
57362 - BPTI-like | 0 | DIRECT |
74650,51445,51011
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0 | DIRECT |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0 | DIRECT |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0 | DIRECT |
56112,82615,82615
56112 - Protein kinase-like (PK-like)
82615 - Polo-box domain
82615 - Polo-box domain | 0 | DIRECT |
51735,48179,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
46938,52087,101576
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain
101576 - Supernatant protein factor (SPF), C-terminal domain | 0 | DIRECT |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
55973,55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | DIRECT |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | DIRECT |
54292,47741,56176
54292 - 2Fe-2S ferredoxin-like
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like | 0 | DIRECT |
57414,57414,57414
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like | 0 | DIRECT |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57567,57567,57567
57567 - Serine protease inhibitors
57567 - Serine protease inhibitors
57567 - Serine protease inhibitors | 0 | DIRECT |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | DIRECT |
50156,50044,52540
50156 - PDZ domain-like
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0 | DIRECT |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | DIRECT |
50249,50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
57938,49493,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
82895,82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
56968,48431,56968
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
56645,47203,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
57625,57625,57625
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins | 0 | DIRECT |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
48452,48452,48452
48452 - TPR-like
48452 - TPR-like
48452 - TPR-like | 0 | DIRECT |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
48371,48371,48371
48371 - ARM repeat
48371 - ARM repeat
48371 - ARM repeat | 0 | DIRECT |
56436,49854,49854
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
90123,52540,90123
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0 | DIRECT |
48726,49265,48726
48726 - Immunoglobulin
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | DIRECT |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
53738,53738,55957
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.1367 | INHERITED FROM: lipid composition variant || drug hypersensitive || nicotine hypersensitive |
56436,56436,49854
56436 - C-type lectin-like
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain | 0.3631 | INHERITED FROM: cadmium hypersensitive || cadmium response variant |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.3638 | INHERITED FROM: protein expression reduced |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.3638 | INHERITED FROM: protein protein interaction variant || protein interaction variant || pattern of transgene expression variant || protein aggregation variant |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.4474 | INHERITED FROM: protein degradation variant || organism metabolism processing variant || protein expression variant || level of protein expression variant || protein expression reduced |
57850,57850,57850
57850 - RING/U-box
57850 - RING/U-box
57850 - RING/U-box | 0.8416 | INHERITED FROM: protein protein interaction variant || protein interaction variant || transgene subcellular localization variant || pattern of transgene expression variant || protein aggregation variant |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.9491 | INHERITED FROM: protein degradation variant || growth rate variant |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.9938 | INHERITED FROM: protein degradation variant || growth rate variant |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
81301,81631,55003
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain
55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | Direct |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | Direct |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | Direct |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
53738,53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | Direct |
52540,90123,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
50044,50044,50044
50044 - SH3-domain
50044 - SH3-domain
50044 - SH3-domain | 0 | Direct |
57362,57362,57362
57362 - BPTI-like
57362 - BPTI-like
57362 - BPTI-like | 0 | Direct |
74650,51445,51011
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0 | Direct |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0 | Direct |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0 | Direct |
56112,82615,82615
56112 - Protein kinase-like (PK-like)
82615 - Polo-box domain
82615 - Polo-box domain | 0 | Direct |
51735,48179,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
46938,52087,101576
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain
101576 - Supernatant protein factor (SPF), C-terminal domain | 0 | Direct |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
55973,55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | Direct |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | Direct |
54292,47741,56176
54292 - 2Fe-2S ferredoxin-like
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like | 0 | Direct |
57414,57414,57414
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like | 0 | Direct |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57567,57567,57567
57567 - Serine protease inhibitors
57567 - Serine protease inhibitors
57567 - Serine protease inhibitors | 0 | Direct |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | Direct |
50156,50044,52540
50156 - PDZ domain-like
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0 | Direct |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | Direct |
50249,50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | Direct |
57938,49493,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
82895,82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | Direct |
56968,48431,56968
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
56645,47203,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
57625,57625,57625
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins | 0 | Direct |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
48452,48452,48452
48452 - TPR-like
48452 - TPR-like
48452 - TPR-like | 0 | Direct |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | Direct |
48371,48371,48371
48371 - ARM repeat
48371 - ARM repeat
48371 - ARM repeat | 0 | Direct |
56436,49854,49854
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | Direct |
90123,52540,90123
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0 | Direct |
48726,49265,48726
48726 - Immunoglobulin
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | Direct |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
53738,53738,55957
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | Direct |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.1367 | Inherited |
56436,56436,49854
56436 - C-type lectin-like
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain | 0.3631 | Inherited |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.3638 | Inherited |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.3638 | Inherited |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.4474 | Inherited |
57850,57850,57850
57850 - RING/U-box
57850 - RING/U-box
57850 - RING/U-box | 0.8416 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.9491 | Inherited |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.9938 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
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