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Worm Phenotype (WP): organism homeostasis metabolism variant

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Variant [WBPhenotype:0000886] <4>
+ + 2:   physiology variant [WBPhenotype:0000519] <7>(489|563) (489|241|65)
+ 1:   organism physiology variant [WBPhenotype:0000576] <10>(357|420) (358|193|57)
0:   organism homeostasis metabolism variant [WBPhenotype:0000577] <17>(347|410) (350|191|56)
- 1:   organism metabolism processing variant [WBPhenotype:0000027] <25>(171|182) (176|81|24)
- 1:   organism environmental stimulus response variant [WBPhenotype:0000738] <16>(115|103) (118|52|16)
- 1:   RNAi response variant [WBPhenotype:0000743] <11>(8|10) (8|4|0)
- 1:   metal homeostasis variant [WBPhenotype:0002029] <6>(0|0) (0|0|0)
- 1:   growth variant [WBPhenotype:0000030] <5>(200|264) (203|114|39)
- 1:   maintenance of gene silencing variant [WBPhenotype:0002063] <4>(11|9) (11|2|0)
- 1:   hydrogen peroxide homeostasis variant [WBPhenotype:0002003] <2>(1|1) (1|0|0)
- 1:   osmotic integrity variant [WBPhenotype:0000041] <2>(6|7) (6|1|0)
- 1:   reactive oxygen species homeostasis variant [WBPhenotype:0002182] <2>(1|1) (1|0|0)
- 1:   ascaroside biosynthesis variant [WBPhenotype:0002051] <1>(2|2) (2|2|1)
- 1:   spontaneous mutation rate increased [WBPhenotype:0000228] <1>(6|5) (6|3|1)
- 1:   cation homeostasis variant [WBPhenotype:0002073](0|0) (0|0|0)
- 1:   hypersensitive to laser ablation [WBPhenotype:0001998](0|0) (0|0|0)
- 1:   hypersensitivity to mutagen [WBPhenotype:0001781](0|0) (0|0|0)
- 1:   protein signaling variant [WBPhenotype:0001207](0|0) (0|0|0)
- 1:   resistant to mutagens [WBPhenotype:0001788](0|0) (0|0|0)
- 1:   starved [WBPhenotype:0000547](0|0) (0|0|0)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
PAP/Archaeal CCA-adding enzyme, C-terminal domain0Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
ThrRS/AlaRS common domain0Direct
Nucleotidyltransferase0Direct
Ribosomal protein S100Direct
Retrovirus zinc finger-like domains0Direct
Nucleoporin domain0Direct
CAD & PB1 domains0Direct
Surp module (SWAP domain)0Direct
Actin-like ATPase domain0Direct
Lamin A/C globular tail domain0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
DNA repair protein MutS, domain III0Direct
Fibrinogen C-terminal domain-like0Direct
Succinyl-CoA synthetase domains0Direct
PIN domain-like0Direct
MOSC N-terminal domain-like0Direct
Restriction endonuclease-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
LysM domain0Direct
Thyroglobulin type-1 domain0Direct
SIS domain0Direct
GroEL-intermediate domain like0Direct
SPOC domain-like0Direct
Ran binding protein zinc finger-like0Direct
HSP40/DnaJ peptide-binding domain0Direct
Translational machinery components0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
DEATH domain0Direct
Integrin alpha N-terminal domain0Direct
Carbon-nitrogen hydrolase0Direct
Ribosomal proteins S24e, L23 and L15e0Direct
Formate/glycerate dehydrogenase catalytic domain-like0Direct
Intermediate filament protein, coiled coil region0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
Ribulose-phoshate binding barrel0Direct
SMAD MH1 domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Cu,Zn superoxide dismutase-like0Direct
PurM N-terminal domain-like0Direct
Small-conductance potassium channel0Direct
Smc hinge domain0Direct
Tubulin nucleotide-binding domain-like0Direct
Lipovitellin-phosvitin complex, superhelical domain0Direct
Sec1/munc18-like (SM) proteins0Direct
Integrin domains0Direct
eIF4e-like0Direct
Clc chloride channel0Direct
Protease propeptides/inhibitors0Direct
Activating enzymes of the ubiquitin-like proteins0Direct
Cytochrome c0Direct
Nucleoside diphosphate kinase, NDK0Direct
PEBP-like0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
Glutathione synthetase ATP-binding domain-like0Direct
FAD-dependent thiol oxidase0Direct
Phosphoenolpyruvate/pyruvate domain0Direct
lambda repressor-like DNA-binding domains0Direct
Terpenoid cyclases/Protein prenyltransferases0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Ferritin-like0Direct
PLC-like phosphodiesterases0Direct
SAND domain-like0Direct
Domain of poly(ADP-ribose) polymerase0Direct
PEP carboxykinase N-terminal domain0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
GroES-like0Direct
Pentein0Direct
FF domain0Direct
Tubby C-terminal domain-like0Direct
NagB/RpiA/CoA transferase-like0Direct
L30e-like0Direct
PEP carboxykinase-like0Direct
Tubulin C-terminal domain-like0Direct
Doublecortin (DC)0Direct
Ribosomal L27 protein-like0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
Subtilisin-like0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
YbiA-like0Direct
Hypothetical protein c14orf129, hspc2100Direct
Cullin homology domain0Direct
Cdc48 domain 2-like0Direct
Bacterial exopeptidase dimerisation domain0Direct
MgtE membrane domain-like0Direct
JAB1/MPN domain0Direct
F1F0 ATP synthase subunit C0Direct
alpha/beta knot0Direct
Skp1 dimerisation domain-like0Direct
Rap/Ran-GAP0Direct
Transducin (heterotrimeric G protein), gamma chain0Direct
Complement control module/SCR domain0Direct
CRAL/TRIO N-terminal domain0Direct
Profilin (actin-binding protein)0Direct
YWTD domain0Direct
Blood coagulation inhibitor (disintegrin)0Direct
Troponin coil-coiled subunits0Direct
Cullin repeat-like0Direct
TK C-terminal domain-like0Direct
Ribosomal protein L10Direct
RBP11-like subunits of RNA polymerase0Direct
Tricorn protease domain 20Direct
t-snare proteins0Direct
Citrate synthase0Direct
FtsH protease domain-like0Direct
beta-lactamase/transpeptidase-like0Direct
PurM C-terminal domain-like0Direct
LEM domain0Direct
L-aspartase-like0Direct
Carbohydrate phosphatase0Direct
Molybdenum cofactor-binding domain0Direct
HSP20-like chaperones0Direct
ADP-ribosylation0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
GYF domain0Direct
Periplasmic binding protein-like II0Direct
Glycolipid transfer protein, GLTP0Direct
3-carboxy-cis,cis-mucoante lactonizing enzyme0Direct
CO dehydrogenase ISP C-domain like0Direct
cAMP-binding domain-like0Direct
ISP domain0Direct
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)0Direct
Putative DNA-binding domain0Direct
WWE domain0Direct
Zn-binding ribosomal proteins0Direct
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase0Direct
Mitochondrial carrier0Direct
GroEL apical domain-like0Direct
Families 57/38 glycoside transferase middle domain0Direct
Clathrin adaptor appendage domain0Direct
Phosphoglucomutase, first 3 domains0Direct
PK beta-barrel domain-like0Direct
Transducin (alpha subunit), insertion domain0Direct
BEACH domain0Direct
Single hybrid motif0Direct
Second domain of FERM0Direct
HCP-like0Direct
PABC (PABP) domain0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
ArfGap/RecO-like zinc finger0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
ALDH-like0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Heme-dependent peroxidases0Direct
Annexin0Direct
Radical SAM enzymes0Direct
Cystatin/monellin0Direct
HSP90 C-terminal domain0Direct
alpha-catenin/vinculin-like0Direct
Acid phosphatase/Vanadium-dependent haloperoxidase0Direct
Ribosomal protein L10-like0Direct
Arginase/deacetylase0Direct
PGBD-like0Direct
Ribokinase-like0Direct
GAS2 domain-like0Direct
Carboxypeptidase regulatory domain-like0Direct
Band 7/SPFH domain0Direct
Zn-finger domain of Sec23/240Direct
PHM/PNGase F0Direct
S-adenosylmethionine synthetase0Direct
Thiolase-like0Direct
Chromo domain-like0Direct
WGR domain-like0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
PLP-binding barrel0Direct
VPS9 domain0Direct
Elafin-like0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Spectrin repeat0Direct
Cadherin-like0Direct
Chaperone J-domain0Direct
Nop domain0Direct
Phosphoglucomutase, C-terminal domain0Direct
Creatinase/prolidase N-terminal domain0Direct
Cation efflux protein cytoplasmic domain-like0Direct
Phoshotransferase/anion transport protein0Direct
R3H domain0Direct
Helical domain of Sec23/240Direct
Galactose mutarotase-like0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Outer arm dynein light chain 10Direct
PreATP-grasp domain0Direct
Rudiment single hybrid motif0Direct
Composite domain of metallo-dependent hydrolases0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
14-3-3 protein0Direct
TGS-like0Direct
Diaminopimelate epimerase-like0Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Cation efflux protein transmembrane domain-like0Direct
2Fe-2S ferredoxin-like0Direct
Invertebrate chitin-binding proteins0Direct
AN1-like Zinc finger0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Polo-box domain0Direct
SWIB/MDM2 domain0Direct
Aldolase0Direct
Terpenoid synthases0Direct
Class I glutamine amidotransferase-like0Direct
Hedgehog/intein (Hint) domain0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
SAICAR synthase-like0Direct
MFPT repeat-like0Direct
PAP/OAS1 substrate-binding domain0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
LDH C-terminal domain-like0Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Proton glutamate symport protein0Direct
GroEL equatorial domain-like0Direct
GAT-like domain0Direct
Chitinase insertion domain0Direct
Sec7 domain0Direct
CBD9-like0Direct
Hormone receptor domain0Direct
ARID-like0Direct
Sec63 N-terminal domain-like0Direct
ENTH/VHS domain0Direct
PYP-like sensor domain (PAS domain)0Direct
Class II aaRS ABD-related0Direct
Heme-dependent catalase-like0Direct
Pepsin inhibitor-30Direct
Oxysterol-binding protein-like0Direct
Tim10-like0Direct
Galactose oxidase, central domain0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
MIR domain0Direct
PH domain-like0.000007844Direct
Histone-fold0.00003003Direct
TPR-like0.007354Inherited
ARM repeat0.00935Inherited
PDZ domain-like0.02477Inherited
Homeodomain-like0.03077Inherited
WD40 repeat-like0.03548Inherited
Acetyl-CoA synthetase-like0.04926Inherited
Cyclin-like0.04926Inherited
CCCH zinc finger0.05555Inherited
"Winged helix" DNA-binding domain0.06308Inherited
Ankyrin repeat0.0688Inherited
Translation proteins0.07046Inherited
HLH, helix-loop-helix DNA-binding domain0.07873Inherited
SMAD/FHA domain0.08916Inherited
SH3-domain0.09263Inherited
EGF/Laminin0.0999Inherited
Calcium ATPase, transmembrane domain M0.1004Inherited
Regulator of G-protein signaling, RGS0.1127Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.1127Inherited
Calcium ATPase, transduction domain A0.1268Inherited
Acid proteases0.1268Inherited
Cysteine-rich domain0.1277Inherited
Cytochrome P4500.1359Inherited
Multidrug efflux transporter AcrB transmembrane domain0.1401Inherited
Quinoprotein alcohol dehydrogenase-like0.1422Inherited
(Trans)glycosidases0.1449Inherited
HMG-box0.1599Inherited
DBL homology domain (DH-domain)0.1599Inherited
ClpP/crotonase0.1599Inherited
Cysteine proteinases0.1824Inherited
RNA-binding domain, RBD0.1975Inherited
P-loop containing nucleoside triphosphate hydrolases0.2045Inherited
ABC transporter transmembrane region0.2186Inherited
Bromodomain0.2255Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.2255Inherited
Lipocalins0.2418Inherited
Protein kinase-like (PK-like)0.2441Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.2492Inherited
SNARE-like0.252Inherited
POZ domain0.2603Inherited
Nicotinic receptor ligand binding domain-like0.2929Inherited
BRCT domain0.3122Inherited
PX domain0.3155Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3324Inherited
RNI-like0.3578Inherited
FKBP-like0.3923Inherited
Class II aaRS and biotin synthetases0.3964Inherited
SH2 domain0.4323Inherited
Myosin rod fragments0.4357Inherited
DHS-like NAD/FAD-binding domain0.4357Inherited
PRTase-like0.4357Inherited
Hect, E3 ligase catalytic domain0.4357Inherited
Galactose-binding domain-like0.4403Inherited
Voltage-gated potassium channels0.4507Inherited
FYVE/PHD zinc finger0.4568Inherited
Cystine-knot cytokines0.4618Inherited
Sm-like ribonucleoproteins0.4618Inherited
WW domain0.4618Inherited
HAD-like0.4769Inherited
Riboflavin synthase domain-like0.4844Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.4844Inherited
Calpain large subunit, middle domain (domain III)0.4844Inherited
UBC-like0.4894Inherited
SAM/Pointed domain0.494Inherited
Multidrug resistance efflux transporter EmrE0.5342Inherited
Seven-hairpin glycosidases0.5391Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.5409Inherited
KA1-like0.5959Inherited
GST C-terminal domain-like0.6129Inherited
S15/NS1 RNA-binding domain0.6607Inherited
4Fe-4S ferredoxins0.6607Inherited
Frizzled cysteine-rich domain0.6607Inherited
Fibronectin type III0.6962Inherited
MIT domain0.7343Inherited
ADC-like0.7343Inherited
PapD-like0.7883Inherited
alpha/beta-Hydrolases0.799Inherited
Leucine zipper domain0.8213Inherited
GTPase activation domain, GAP0.8244Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.8373Inherited
Immunoglobulin0.8552Inherited
Ubiquitin-like0.8679Inherited
p53-like transcription factors0.8709Inherited
Thioredoxin-like0.8832Inherited
EF-hand0.884Inherited
Nucleic acid-binding proteins0.9089Inherited
Ribonuclease PH domain 2-like0.9147Inherited
MFS general substrate transporter0.9308Inherited
Eukaryotic type KH-domain (KH-domain type I)0.9403Inherited
Periplasmic binding protein-like I0.9577Inherited
FAD/NAD(P)-binding domain0.9603Inherited
Cyclophilin-like0.9634Inherited
CoA-dependent acyltransferases0.9634Inherited
Nucleotide cyclase0.9699Inherited
PAZ domain0.9702Inherited
Ribosomal protein S5 domain 2-like0.9779Inherited
SET domain0.9806Inherited
Ligand-binding domain in the NO signalling and Golgi transport0.9891Inherited
Ribonuclease H-like0.9952Inherited
Snake toxin-like1Inherited
E set domains1Inherited
UBA-like1Inherited
Translation proteins SH3-like domain1Inherited
F-box domain1Inherited
Saposin1Inherited
Acyl-CoA dehydrogenase C-terminal domain-like1Inherited
Acyl-CoA dehydrogenase NM domain-like1Inherited
dsRNA-binding domain-like1Inherited
beta-beta-alpha zinc fingers1Inherited
Family A G protein-coupled receptor-like1Inherited
Nuclear receptor ligand-binding domain1Inherited
Bet v1-like1Inherited
B-box zinc-binding domain1Inherited
Nucleotidylyl transferase1Inherited
Clavaminate synthase-like1Inherited
RING/U-box1Inherited
DNA/RNA polymerases1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain0Direct
Inositol monophosphatase/fructose-1,6-bisphosphatase-like0Direct
Aminoacid dehydrogenase-like, C-terminal domain0Direct
HSP40/DnaJ peptide-binding domain0Direct
Thyroglobulin type-1 domain0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain0Direct
Third domain of FERM0Direct
YbiA-like0Direct
YWTD domain0Direct
PDI-like0Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Glycerophosphoryl diester phosphodiesterase0Direct
ALDH-like0Direct
Fatty acid binding protein-like0Direct
Anticodon-binding domain0Direct
Paired domain0Direct
Branched-chain alpha-keto acid dehydrogenase PP module0Direct
Cation efflux protein cytoplasmic domain-like0Direct
LysM domain0Direct
AMPK-beta glycogen binding domain-like0Direct
Methionine aminopeptidase, insert domain0Direct
Myotubularin-like phosphatases0Direct
DPP6 N-terminal domain-like0Direct
Blood coagulation inhibitor (disintegrin)0Direct
Poly(A) polymerase, PAP, N-terminal domain0Direct
Laminin G-like module0Direct
UBA domain0Direct
Armadillo repeat0Direct
Single strand DNA-binding domain, SSB0Direct
Glycogenin0Direct
Phosphoglucomutase, first 3 domains0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Sec1/munc18-like (SM) proteins0Direct
Troponin I0Direct
Integrin domains0Direct
RNA-polymerase beta0Direct
L30e/L7ae ribosomal proteins0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
PEP carboxykinase N-terminal domain0Direct
HD domain0Direct
CUT domain0Direct
AN1-like Zinc finger0Direct
Band 7/SPFH domain0Direct
alpha-mannosidase0Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
Arylsulfatase0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Cu,Zn superoxide dismutase-like0Direct
Matrix metalloproteases, catalytic domain0Direct
RNA editing terminal uridyl transferase 2, RET2, domain 20Direct
Calpain large subunit, catalytic domain (domain II)0Direct
beta 1,4 galactosyltransferase (b4GalT1)0Direct
Actin/HSP700Direct
Transducin (alpha subunit), insertion domain0Direct
Cadherin0Direct
RecA protein-like (ATPase-domain)0Direct
Quinoprotein alcohol dehydrogenase-like0Direct
VHS domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Ribosomal protein L18 and S110Direct
SMAD domain0Direct
Chitinase insertion domain0Direct
Regulator of chromosome condensation RCC10Direct
Proton glutamate symport protein0Direct
Clathrin coat assembly domain0Direct
Ribosomal protein L10Direct
Second domain of FERM0Direct
Reprolysin-like0Direct
Poly(A) polymerase, PAP, C-terminal domain0Direct
Lactate & malate dehydrogenases, C-terminal domain0Direct
Molybdenum cofactor-binding domain0Direct
Ran binding protein zinc finger-like0Direct
Myeloperoxidase-like0Direct
MIF4G domain-like0Direct
Annexin0Direct
BEACH domain0Direct
Cullin repeat0Direct
Sec63 C-terminal domain-like0Direct
FtsH protease domain-like0Direct
5' to 3' exonuclease catalytic domain0Direct
Ubiquitin activating enzymes (UBA)0Direct
alpha-mannosidase, C-terminal domain0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
Acireductone dioxygenase0Direct
Epoxide hydrolase0Direct
BC C-terminal domain-like0Direct
PABC (PABP) domain0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain0Direct
U-box0Direct
MOSC N-terminal domain-like0Direct
Ribokinase-like0Direct
PEP carboxykinase C-terminal domain0Direct
Proprotein convertase P-domain0Direct
ets domain0Direct
Lesion bypass DNA polymerase (Y-family), catalytic domain0Direct
Surp module (SWAP domain)0Direct
Bactericidal permeability-increasing protein, BPI0Direct
Poly(A) polymerase, PAP, middle domain0Direct
Inositol polyphosphate kinase (IPK)0Direct
Tetraspanin0Direct
Type II chitinase0Direct
Dual specificity phosphatase-like0Direct
Alcohol dehydrogenase-like, C-terminal domain0Direct
Spectrin repeat0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
Histone deacetylase, HDAC0Direct
Cation efflux protein transmembrane domain-like0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
beta-Lactamase/D-ala carboxypeptidase0Direct
Adenain-like0Direct
Clathrin adaptor core protein0Direct
CO dehydrogenase flavoprotein N-terminal domain-like0Direct
Acyl-carrier protein (ACP)0Direct
BAR domain0Direct
Arginine methyltransferase0Direct
LDH N-terminal domain-like0Direct
Calcium ATPase, transmembrane domain M0Direct
GYF domain0Direct
CAT-like0Direct
SWIRM domain0Direct
YihX-like0Direct
MIR domain0Direct
Translation initiation factor eIF4e0Direct
Nop domain0Direct
Intermediate filament protein, coiled coil region0Direct
Fibrinogen C-terminal domain-like0Direct
HCDH C-domain-like0Direct
Glycosyl transferases group 10Direct
ATP-dependent protease Lon (La), catalytic domain0Direct
1,3-glucuronyltransferase0Direct
Ngr ectodomain-like0Direct
BC N-terminal domain-like0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Phosphatidylethanolamine binding protein0Direct
Biotin dependent carboxylase carboxyltransferase domain0Direct
Translational machinery components0Direct
Phosphotyrosine-binding domain (PTB)0Direct
DPP6 catalytic domain-like0Direct
28-residue LRR0Direct
S-adenosylmethionine synthetase0Direct
Linker histone H1/H50Direct
Ribosomal protein S100Direct
Nucleosome core histones0Direct
NHL repeat0Direct
Alcohol dehydrogenase-like, N-terminal domain0Direct
Phosphate binding protein-like0Direct
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Regulator of G-protein signaling, RGS0Direct
Anticodon-binding domain of Class II aaRS0Direct
MFPT repeat0Direct
Subtilases0Direct
Class I aldolase0Direct
Hydantoinase (dihydropyrimidinase)0Direct
D-aminoacid oxidase, N-terminal domain0Direct
Hedgehog C-terminal (Hog) autoprocessing domain0Direct
14-3-3 protein0Direct
p120GAP domain-like0Direct
Skp1 dimerisation domain-like0Direct
CoA transferase alpha subunit-like0Direct
CO dehydrogenase ISP C-domain like0Direct
Protein prenyltransferases0Direct
Cullin homology domain0Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
Polo-box duplicated region0Direct
LEM domain0Direct
Acyl-CoA thioesterase0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
Bacterial exopeptidase dimerisation domain0Direct
Amylase, catalytic domain0Direct
Group II chaperonin (CCT, TRIC), apical domain0Direct
L-aminoacid/polyamine oxidase0Direct
Pancreatic carboxypeptidases0Direct
First domain of FERM0Direct
Hormone receptor domain0Direct
DEP domain0Direct
Hydantoinase (dihydropyrimidinase), catalytic domain0Direct
Complement control module/SCR domain0Direct
La domain0Direct
Class I glutamine amidotransferases (GAT)0Direct
Elafin-like0Direct
Domain of poly(ADP-ribose) polymerase0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
NTF2-like0Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0Direct
Tubulin, GTPase domain0Direct
Oxysterol-binding protein0Direct
Pancreatic carboxypeptidase, activation domain0Direct
Erythroid transcription factor GATA-10Direct
Heme-dependent catalases0Direct
CoA-binding domain0Direct
Clc chloride channel0Direct
Hypothetical protein c14orf129, hspc2100Direct
Class II glutamine amidotransferases0Direct
COMT-like0Direct
Retrovirus zinc finger-like domains0Direct
Pepsin inhibitor-30Direct
SCF ubiquitin ligase complex WHB domain0Direct
acyl-CoA oxidase C-terminal domains0Direct
Succinyl-CoA synthetase domains0Direct
DEATH domain, DD0Direct
Lamin A/C globular tail domain0Direct
SWIB/MDM2 domain0Direct
cAMP-binding domain0Direct
SAND domain0Direct
RhoGDI-like0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
D-aminoacid oxidase-like0Direct
Nucleoside diphosphate kinase, NDK0Direct
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)0Direct
GAS2 domain0Direct
UDP-glucose pyrophosphorylase0Direct
2Fe-2S ferredoxin domains from multidomain proteins0Direct
PhzC/PhzF-like0Direct
Glycerol kinase0Direct
POU-specific domain0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
Reductases0Direct
Glutaminase0Direct
FHA domain0Direct
CRAL/TRIO N-terminal domain0Direct
Thiolase-related0Direct
Pleckstrin-homology domain (PH domain)0Direct
Cyclin0Direct
Pumilio repeat0Direct
Cofilin-like0Direct
PurM N-terminal domain-like0Direct
Tim10/DDP0Direct
alpha-mannosidase, domain 20Direct
XPF/Rad1/Mus81 nuclease0Direct
WGR domain0Direct
acyl-CoA oxidase N-terminal domains0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
F1F0 ATP synthase subunit C0Direct
Trunk domain of Sec23/240Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
PaaI/YdiI-like0Direct
Choline kinase0Direct
Mitochondrial carrier0Direct
NOL1/NOP2/sun0Direct
Formate/glycerate dehydrogenases, NAD-domain0Direct
Hexokinase0Direct
Transducin (heterotrimeric G protein), gamma chain0Direct
Sir2 family of transcriptional regulators0Direct
t-snare proteins0Direct
PUA domain0Direct
Sec7 domain0Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
alpha-catenin/vinculin0Direct
Zn-finger domain of Sec23/240Direct
Helical domain of Sec23/240Direct
Chaperone J-domain0Direct
HEAT repeat0Direct
FAD-dependent thiol oxidase0Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
Internalin LRR domain0Direct
SAM (sterile alpha motif) domain0Direct
GAPDH-like0Direct
YicI catalytic domain-like0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Ferredoxin reductase FAD-binding domain-like0Direct
HSP90 C-terminal domain0Direct
Adenosine/AMP deaminase0Direct
Biotinyl/lipoyl-carrier proteins and domains0Direct
BC ATP-binding domain-like0Direct
Sec63 N-terminal domain0Direct
Acylamino-acid-releasing enzyme, C-terminal donain0Direct
Phosphoribosyltransferases (PRTases)0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
Arfaptin, Rac-binding fragment0Direct
Peptidylglycine alpha-hydroxylating monooxygenase, PHM0Direct
Cell cycle control phosphatase, catalytic domain0Direct
PurM C-terminal domain-like0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
Citrate synthase0Direct
ARID domain0Direct
Hsp90 middle domain0Direct
RNA-polymerase beta-prime0Direct
Brix domain0Direct
Poly(ADP-ribose) polymerase, C-terminal domain0Direct
Doublecortin (DC)0Direct
Pyk2-associated protein beta ARF-GAP domain0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
Cytoplasmic domain of inward rectifier potassium channel0Direct
Profilin (actin-binding protein)0Direct
Branched-chain alpha-keto acid dehydrogenase Pyr module0Direct
HSP200Direct
WWE domain0Direct
HAT/Suf repeat0Direct
a tRNA synthase domain0Direct
Glycolipid transfer protein, GLTP0Direct
Tubulin, C-terminal domain0Direct
Group II chaperonin (CCT, TRIC), ATPase domain0Direct
beta-sandwich domain of Sec23/240Direct
Rap/Ran-GAP0Direct
Carboxypeptidase regulatory domain0Direct
Gamma-glutamyltranspeptidase-like0Direct
IF2B-like0Direct
Proteasome subunits0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
SMAD MH1 domain0Direct
Cdc48 domain 2-like0Direct
Small-conductance potassium channel0Direct
LacY-like proton/sugar symporter0Direct
MutT-like0Direct
DNA repair protein MutS, domain III0Direct
Lipovitellin-phosvitin complex, superhelical domain0Direct
Mammalian PLC0Direct
Chromo domain0Direct
FF domain0Direct
Smc hinge domain0Direct
PLC-like (P variant)0Direct
Ras-binding domain, RBD0Direct
Tandem AAA-ATPase domain0.002382Inherited
Homeodomain0.02201Inherited
G proteins0.02461Inherited
WD40-repeat0.02644Inherited
PDZ domain0.0393Inherited
Canonical RBD0.05623Inherited
Acetyl-CoA synthetase-like0.06094Inherited
CCCH zinc finger0.068Inherited
ABC transporter ATPase domain-like0.07564Inherited
Tetratricopeptide repeat (TPR)0.0857Inherited
HLH, helix-loop-helix DNA-binding domain0.1024Inherited
Ankyrin repeat0.1197Inherited
SH3-domain0.1332Inherited
Calcium ATPase, transduction domain A0.145Inherited
Elongation factors0.1797Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.1797Inherited
HMG-box0.1797Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.1797Inherited
DBL homology domain (DH-domain)0.1797Inherited
Pepsin-like0.2003Inherited
Cytochrome P4500.2014Inherited
Extended AAA-ATPase domain0.2051Inherited
Multidrug efflux transporter AcrB transmembrane domain0.2212Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.2221Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.2433Inherited
Bromodomain0.2469Inherited
6-phosphogluconate dehydrogenase-like, N-terminal domain0.2469Inherited
FYVE, a phosphatidylinositol-3-phosphate binding domain0.2469Inherited
Protein kinases, catalytic subunit0.2477Inherited
FAD/NAD-linked reductases, N-terminal and central domains0.2739Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP0.3042Inherited
Crotonase-like0.3042Inherited
Meta-cation ATPase, catalytic domain P0.3042Inherited
TBP-associated factors, TAFs0.3376Inherited
PX domain0.3376Inherited
ABC transporter transmembrane region0.3503Inherited
GABA-aminotransferase-like0.3737Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.3803Inherited
FKBP immunophilin/proline isomerase0.4127Inherited
Nicotinic receptor ligand binding domain-like0.4195Inherited
Glutathione S-transferase (GST), N-terminal domain0.4198Inherited
Acetylcholinesterase-like0.4421Inherited
Hect, E3 ligase catalytic domain0.456Inherited
Pyridoxal-dependent decarboxylase0.456Inherited
Papain-like0.4684Inherited
I set domains0.4692Inherited
WW domain0.5025Inherited
Myb/SANT domain0.5036Inherited
Gastric lipase0.5036Inherited
Calpain large subunit, middle domain (domain III)0.5036Inherited
UBC-related0.5234Inherited
BTB/POZ domain0.5331Inherited
SH2 domain0.5331Inherited
Class I alpha-1;2-mannosidase, catalytic domain0.5541Inherited
Synaptotagmin-like (S variant)0.5707Inherited
Ubiquitin carboxyl-terminal hydrolase, UCH0.6081Inherited
Frizzled cysteine-rich domain0.6752Inherited
EF-hand modules in multidomain proteins0.6752Inherited
Transforming growth factor (TGF)-beta0.6752Inherited
Ubiquitin-related0.6858Inherited
PHD domain0.7002Inherited
Voltage-gated potassium channels0.701Inherited
Bacterial lipase0.7436Inherited
Cdc48 N-terminal domain-like0.7436Inherited
MIT domain0.7436Inherited
H-NOX domain0.7436Inherited
MSP-like0.7881Inherited
LIM domain0.8074Inherited
Glutathione S-transferase (GST), C-terminal domain0.8297Inherited
Leucine zipper domain0.8606Inherited
Calmodulin-like0.861Inherited
Extended PAW domain0.8793Inherited
Ribonuclease PH domain 1-like0.9257Inherited
Ribonuclease PH domain 2-like0.9257Inherited
Adenylyl and guanylyl cyclase catalytic domain0.9467Inherited
L-arabinose binding protein-like0.9667Inherited
Choline/Carnitine O-acyltransferase0.98Inherited
Cyclophilin (peptidylprolyl isomerase)0.982Inherited
Cold shock DNA-binding domain-like0.9945Inherited
Nuclear receptor ligand-binding domain0.998Inherited
Nuclear receptor1Inherited
Glutathione peroxidase-like1Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain1Inherited
PAZ domain1Inherited
N-acetyl transferase, NAT1Inherited
F-box domain1Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains1Inherited
Rhodopsin-like1Inherited
DnaQ-like 3'-5' exonuclease1Inherited
Histone lysine methyltransferases1Inherited
B-box zinc-binding domain1Inherited
Double-stranded RNA-binding domain (dsRBD)1Inherited
RING finger domain, C3HC41Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
DEATH domain0Direct
GroEL equatorial domain-like0Direct
Oxysterol-binding protein-like0Direct
Formate/glycerate dehydrogenase catalytic domain-like0Direct
ADP-ribosylation0Direct
PEP carboxykinase N-terminal domain0Direct
MOSC N-terminal domain-like0Direct
Clathrin adaptor appendage domain0Direct
Heme-dependent peroxidases0Direct
ThrRS/AlaRS common domain0Direct
Clc chloride channel0Direct
Translational machinery components0Direct
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)0Direct
Complement control module/SCR domain0Direct
HCP-like0Direct
Nop domain0Direct
Bacterial exopeptidase dimerisation domain0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
Succinyl-CoA synthetase domains0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
NagB/RpiA/CoA transferase-like0Direct
Diaminopimelate epimerase-like0Direct
PEP carboxykinase-like0Direct
alpha/beta knot0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
Heme-dependent catalase-like0Direct
GroES-like0Direct
GAT-like domain0Direct
Phosphoglucomutase, first 3 domains0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
Galactose mutarotase-like0Direct
Families 57/38 glycoside transferase middle domain0Direct
Ferritin-like0Direct
Skp1 dimerisation domain-like0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
PABC (PABP) domain0Direct
Integrin alpha N-terminal domain0Direct
t-snare proteins0Direct
Cdc48 domain 2-like0Direct
Pentein0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
SAICAR synthase-like0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
MgtE membrane domain-like0Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0Direct
Ribosomal proteins S24e, L23 and L15e0Direct
Fibrinogen C-terminal domain-like0Direct
Creatinase/prolidase N-terminal domain0Direct
Elafin-like0Direct
Small-conductance potassium channel0Direct
Chaperone J-domain0Direct
Terpenoid synthases0Direct
LysM domain0Direct
Galactose oxidase, central domain0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Class II aaRS ABD-related0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Tim10-like0Direct
Ran binding protein zinc finger-like0Direct
YWTD domain0Direct
Annexin0Direct
Cadherin-like0Direct
PYP-like sensor domain (PAS domain)0Direct
Hypothetical protein c14orf129, hspc2100Direct
PHM/PNGase F0Direct
Terpenoid cyclases/Protein prenyltransferases0Direct
PEBP-like0Direct
Blood coagulation inhibitor (disintegrin)0Direct
Class I glutamine amidotransferase-like0Direct
Invertebrate chitin-binding proteins0Direct
Polo-box domain0Direct
ValRS/IleRS/LeuRS editing domain0Direct
lambda repressor-like DNA-binding domains0Direct
FAD-dependent thiol oxidase0Direct
Aldolase0Direct
Tricorn protease domain 20Direct
Mitochondrial carrier0Direct
HSP20-like chaperones0Direct
BEACH domain0Direct
R3H domain0Direct
HSP40/DnaJ peptide-binding domain0Direct
Carbohydrate phosphatase0Direct
Carbon-nitrogen hydrolase0Direct
TK C-terminal domain-like0Direct
PGBD-like0Direct
DNA repair protein MutS, domain III0Direct
Carboxypeptidase regulatory domain-like0Direct
CRAL/TRIO N-terminal domain0Direct
2Fe-2S ferredoxin-like0Direct
Activating enzymes of the ubiquitin-like proteins0Direct
Helical domain of Sec23/240Direct
Cystatin/monellin0Direct
PAP/Archaeal CCA-adding enzyme, C-terminal domain0Direct
GYF domain0Direct
Domain of poly(ADP-ribose) polymerase0Direct
Spectrin repeat0Direct
L-aspartase-like0Direct
Cullin homology domain0Direct
Thyroglobulin type-1 domain0Direct
Hedgehog/intein (Hint) domain0Direct
AN1-like Zinc finger0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Ribokinase-like0Direct
ALDH-like0Direct
Cation efflux protein cytoplasmic domain-like0Direct
Chitinase insertion domain0Direct
beta-lactamase/transpeptidase-like0Direct
Outer arm dynein light chain 10Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Molybdenum cofactor-binding domain0Direct
Cation efflux protein transmembrane domain-like0Direct
Protease propeptides/inhibitors0Direct
Thiolase-like0Direct
Putative DNA-binding domain0Direct
Ribosomal protein L10Direct
WWE domain0Direct
CBD9-like0Direct
Citrate synthase0Direct
cAMP-binding domain-like0Direct
Single hybrid motif0Direct
Nucleoporin domain0Direct
Ribosomal protein S100Direct
14-3-3 protein0Direct
FtsH protease domain-like0Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Ribosomal protein L10-like0Direct
Periplasmic binding protein-like II0Direct
Ribosomal L27 protein-like0Direct
Zn-binding ribosomal proteins0Direct
JAB1/MPN domain0Direct
Sec63 N-terminal domain-like0Direct
Intermediate filament protein, coiled coil region0Direct
Phosphoglucomutase, C-terminal domain0Direct
Surp module (SWAP domain)0Direct
Band 7/SPFH domain0Direct
GAS2 domain-like0Direct
Profilin (actin-binding protein)0Direct
ArfGap/RecO-like zinc finger0Direct
MIR domain0Direct
CO dehydrogenase ISP C-domain like0Direct
eIF4e-like0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
PreATP-grasp domain0Direct
SMAD MH1 domain0Direct
Sec7 domain0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
Lipovitellin-phosvitin complex, superhelical domain0Direct
Subtilisin-like0Direct
Pepsin inhibitor-30Direct
TGS-like0Direct
LEM domain0Direct
Tubby C-terminal domain-like0Direct
ISP domain0Direct
Cu,Zn superoxide dismutase-like0Direct
Zn-finger domain of Sec23/240Direct
Troponin coil-coiled subunits0Direct
Composite domain of metallo-dependent hydrolases0Direct
Second domain of FERM0Direct
PLC-like phosphodiesterases0Direct
Phosphoenolpyruvate/pyruvate domain0Direct
alpha-catenin/vinculin-like0Direct
CAD & PB1 domains0Direct
VPS9 domain0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
Restriction endonuclease-like0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Nucleoside diphosphate kinase, NDK0Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0Direct
Rudiment single hybrid motif0Direct
Ribulose-phoshate binding barrel0Direct
Sec1/munc18-like (SM) proteins0Direct
Chromo domain-like0Direct
HSP90 C-terminal domain0Direct
PurM C-terminal domain-like0Direct
Lamin A/C globular tail domain0Direct
Doublecortin (DC)0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
PLP-binding barrel0Direct
Phoshotransferase/anion transport protein0Direct
Nucleotidyltransferase0Direct
Integrin domains0Direct
WGR domain-like0Direct
Transducin (heterotrimeric G protein), gamma chain0Direct
F1F0 ATP synthase subunit C0Direct
3-carboxy-cis,cis-mucoante lactonizing enzyme0Direct
GroEL apical domain-like0Direct
Smc hinge domain0Direct
YbiA-like0Direct
SIS domain0Direct
Arginase/deacetylase0Direct
Radical SAM enzymes0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
Glycolipid transfer protein, GLTP0Direct
Cytochrome c0Direct
Cullin repeat-like0Direct
Rap/Ran-GAP0Direct
Tubulin nucleotide-binding domain-like0Direct
PAP/OAS1 substrate-binding domain0Direct
Proton glutamate symport protein0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
LDH C-terminal domain-like0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Transducin (alpha subunit), insertion domain0Direct
ARID-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
SAND domain-like0Direct
SWIB/MDM2 domain0Direct
Acid phosphatase/Vanadium-dependent haloperoxidase0Direct
Tubulin C-terminal domain-like0Direct
Hormone receptor domain0Direct
Glutathione synthetase ATP-binding domain-like0Direct
PurM N-terminal domain-like0Direct
ENTH/VHS domain0Direct
S-adenosylmethionine synthetase0Direct
GroEL-intermediate domain like0Direct
RBP11-like subunits of RNA polymerase0Direct
FF domain0Direct
SPOC domain-like0Direct
Retrovirus zinc finger-like domains0Direct
PK beta-barrel domain-like0Direct
PIN domain-like0Direct
MFPT repeat-like0Direct
L30e-like0Direct
Actin-like ATPase domain0Direct
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase0Direct
PH domain-like0.000006413Direct
Histone-fold0.00002467Direct
TPR-like0.006301Inherited
ARM repeat0.008039Inherited
PDZ domain-like0.02165Inherited
Homeodomain-like0.02701Inherited
WD40 repeat-like0.03127Inherited
Acetyl-CoA synthetase-like0.04369Inherited
Cyclin-like0.04369Inherited
CCCH zinc finger0.04936Inherited
"Winged helix" DNA-binding domain0.05625Inherited
Ankyrin repeat0.06148Inherited
Translation proteins0.063Inherited
HLH, helix-loop-helix DNA-binding domain0.07066Inherited
SMAD/FHA domain0.08024Inherited
SH3-domain0.08344Inherited
EGF/Laminin0.09017Inherited
Calcium ATPase, transmembrane domain M0.09061Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.1021Inherited
Regulator of G-protein signaling, RGS0.1021Inherited
Acid proteases0.1153Inherited
Calcium ATPase, transduction domain A0.1153Inherited
Cysteine-rich domain0.1162Inherited
Cytochrome P4500.1239Inherited
Multidrug efflux transporter AcrB transmembrane domain0.1279Inherited
Quinoprotein alcohol dehydrogenase-like0.1298Inherited
(Trans)glycosidases0.1323Inherited
HMG-box0.1464Inherited
DBL homology domain (DH-domain)0.1464Inherited
ClpP/crotonase0.1464Inherited
Cysteine proteinases0.1675Inherited
RNA-binding domain, RBD0.1819Inherited
P-loop containing nucleoside triphosphate hydrolases0.1885Inherited
ABC transporter transmembrane region0.2021Inherited
Bromodomain0.2086Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.2086Inherited
Lipocalins0.2242Inherited
Protein kinase-like (PK-like)0.2265Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.2315Inherited
SNARE-like0.2342Inherited
POZ domain0.2423Inherited
Nicotinic receptor ligand binding domain-like0.2738Inherited
BRCT domain0.2926Inherited
PX domain0.2959Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3125Inherited
RNI-like0.3375Inherited
FKBP-like0.3716Inherited
Class II aaRS and biotin synthetases0.3755Inherited
SH2 domain0.4109Inherited
Myosin rod fragments0.4143Inherited
PRTase-like0.4143Inherited
Hect, E3 ligase catalytic domain0.4143Inherited
DHS-like NAD/FAD-binding domain0.4143Inherited
Galactose-binding domain-like0.419Inherited
Voltage-gated potassium channels0.4292Inherited
FYVE/PHD zinc finger0.4354Inherited
Sm-like ribonucleoproteins0.4402Inherited
Cystine-knot cytokines0.4402Inherited
WW domain0.4402Inherited
HAD-like0.4551Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.4628Inherited
Riboflavin synthase domain-like0.4628Inherited
Calpain large subunit, middle domain (domain III)0.4628Inherited
UBC-like0.4674Inherited
SAM/Pointed domain0.4718Inherited
Multidrug resistance efflux transporter EmrE0.512Inherited
Seven-hairpin glycosidases0.517Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.5188Inherited
KA1-like0.5736Inherited
GST C-terminal domain-like0.5908Inherited
4Fe-4S ferredoxins0.6394Inherited
S15/NS1 RNA-binding domain0.6394Inherited
Frizzled cysteine-rich domain0.6394Inherited
Fibronectin type III0.6754Inherited
ADC-like0.714Inherited
MIT domain0.714Inherited
PapD-like0.769Inherited
alpha/beta-Hydrolases0.78Inherited
Leucine zipper domain0.8029Inherited
GTPase activation domain, GAP0.8059Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.8194Inherited
Immunoglobulin0.8382Inherited
Ubiquitin-like0.8515Inherited
p53-like transcription factors0.8545Inherited
Thioredoxin-like0.8673Inherited
EF-hand0.8682Inherited
Nucleic acid-binding proteins0.894Inherited
Ribonuclease PH domain 2-like0.9Inherited
MFS general substrate transporter0.9169Inherited
Eukaryotic type KH-domain (KH-domain type I)0.9266Inherited
Periplasmic binding protein-like I0.9447Inherited
FAD/NAD(P)-binding domain0.9475Inherited
Cyclophilin-like0.9507Inherited
CoA-dependent acyltransferases0.9507Inherited
Nucleotide cyclase0.9576Inherited
PAZ domain0.9579Inherited
Ribosomal protein S5 domain 2-like0.9664Inherited
SET domain0.9692Inherited
Ligand-binding domain in the NO signalling and Golgi transport0.9781Inherited
Calponin-homology domain, CH-domain0.9813Inherited
Ribonuclease H-like0.9847Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.9957Inherited
Acyl-CoA dehydrogenase NM domain-like0.9957Inherited
Nucleotidylyl transferase0.9957Inherited
Snake toxin-like1Inherited
F-box domain1Inherited
DNA/RNA polymerases1Inherited
B-box zinc-binding domain1Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase1Inherited
Family A G protein-coupled receptor-like1Inherited
Insulin-like1Inherited
Bet v1-like1Inherited
dsRNA-binding domain-like1Inherited
Nuclear receptor ligand-binding domain1Inherited
RING/U-box1Inherited
Clavaminate synthase-like1Inherited
E set domains1Inherited
UBA-like1Inherited
beta-beta-alpha zinc fingers1Inherited
Translation proteins SH3-like domain1Inherited
Saposin1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0Direct
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0Direct
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    81383,50978
  • 81383 - F-box domain
  • 50978 - WD40 repeat-like
  • 0Direct
    51735,55347
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    81383,52047
  • 81383 - F-box domain
  • 52047 - RNI-like
  • 0Direct
    47203,47203
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    53738,55957
  • 53738 - Phosphoglucomutase, first 3 domains
  • 55957 - Phosphoglucomutase, C-terminal domain
  • 0Direct
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0Direct
    52283,51735
  • 52283 - Formate/glycerate dehydrogenase catalytic domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    141673,50800
  • 141673 - MOSC N-terminal domain-like
  • 50800 - PK beta-barrel domain-like
  • 0Direct
    48179,48179
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    88713,88688
  • 88713 - Glycoside hydrolase/deacetylase
  • 88688 - Families 57/38 glycoside transferase middle domain
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    50044,52540
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    46938,52087
  • 46938 - CRAL/TRIO N-terminal domain
  • 52087 - CRAL/TRIO domain
  • 0Direct
    55920,46785
  • 55920 - Creatinase/aminopeptidase
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    57850,117839
  • 57850 - RING/U-box
  • 117839 - WWE domain
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    57756,57756
  • 57756 - Retrovirus zinc finger-like domains
  • 57756 - Retrovirus zinc finger-like domains
  • 0Direct
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0Direct
    64356,49447
  • 64356 - SNARE-like
  • 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor
  • 0Direct
    82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    57625,57625
  • 57625 - Invertebrate chitin-binding proteins
  • 57625 - Invertebrate chitin-binding proteins
  • 0Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0Direct
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    48425,50729
  • 48425 - Sec7 domain
  • 50729 - PH domain-like
  • 0Direct
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    57362,57362
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 0Direct
    54897,52743
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 0Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0Direct
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0Direct
    51905,56425
  • 51905 - FAD/NAD(P)-binding domain
  • 56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
  • 0Direct
    57414,57414
  • 57414 - Hairpin loop containing domain-like
  • 57414 - Hairpin loop containing domain-like
  • 0Direct
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    51445,54556
  • 51445 - (Trans)glycosidases
  • 54556 - Chitinase insertion domain
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    54665,56003
  • 54665 - CO dehydrogenase molybdoprotein N-domain-like
  • 56003 - Molybdenum cofactor-binding domain
  • 0Direct
    57863,48403
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0Direct
    68923,53795
  • 68923 - PEP carboxykinase N-terminal domain
  • 53795 - PEP carboxykinase-like
  • 0Direct
    47576,47576
  • 47576 - Calponin-homology domain, CH-domain
  • 47576 - Calponin-homology domain, CH-domain
  • 0Direct
    52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0Direct
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0Direct
    52047,52047
  • 52047 - RNI-like
  • 52047 - RNI-like
  • 0Direct
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0Direct
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    47473,103506
  • 47473 - EF-hand
  • 103506 - Mitochondrial carrier
  • 0Direct
    161111,160240
  • 161111 - Cation efflux protein transmembrane domain-like
  • 160240 - Cation efflux protein cytoplasmic domain-like
  • 0Direct
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    48464,89009
  • 48464 - ENTH/VHS domain
  • 89009 - GAT-like domain
  • 0Direct
    50129,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0Direct
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    54236,54236
  • 54236 - Ubiquitin-like
  • 54236 - Ubiquitin-like
  • 0Direct
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    56672,100879
  • 56672 - DNA/RNA polymerases
  • 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain
  • 0Direct
    81324,81327
  • 81324 - Voltage-gated potassium channels
  • 81327 - Small-conductance potassium channel
  • 0Direct
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    51556,51338
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    47741,56176
  • 47741 - CO dehydrogenase ISP C-domain like
  • 56176 - FAD-binding/transporter-associated domain-like
  • 0Direct
    51971,54373
  • 51971 - Nucleotide-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 0Direct
    55394,55394
  • 55394 - Bactericidal permeability-increasing protein, BPI
  • 55394 - Bactericidal permeability-increasing protein, BPI
  • 0Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0Direct
    53901,53901
  • 53901 - Thiolase-like
  • 53901 - Thiolase-like
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0Direct
    100950,100950
  • 100950 - NagB/RpiA/CoA transferase-like
  • 100950 - NagB/RpiA/CoA transferase-like
  • 0Direct
    57889,48350
  • 57889 - Cysteine-rich domain
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    47769,47769
  • 47769 - SAM/Pointed domain
  • 47769 - SAM/Pointed domain
  • 0Direct
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    52540,81271
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 81271 - TGS-like
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0Direct
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0Direct
    57196,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0Direct
    49348,55711
  • 49348 - Clathrin adaptor appendage domain
  • 55711 - Subdomain of clathrin and coatomer appendage domain
  • 0Direct
    52540,46785
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    53187,49464
  • 53187 - Zn-dependent exopeptidases
  • 49464 - Carboxypeptidase regulatory domain-like
  • 0Direct
    50156,50044
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 0Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    54292,47741
  • 54292 - 2Fe-2S ferredoxin-like
  • 47741 - CO dehydrogenase ISP C-domain like
  • 0Direct
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    50978,50998
  • 50978 - WD40 repeat-like
  • 50998 - Quinoprotein alcohol dehydrogenase-like
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0Direct
    46785,46785
  • 46785 - "Winged helix" DNA-binding domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    53738,53738
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 0Direct
    52743,49785
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0Direct
    55729,55729
  • 55729 - Acyl-CoA N-acyltransferases (Nat)
  • 55729 - Acyl-CoA N-acyltransferases (Nat)
  • 0Direct
    52540,140990
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 140990 - FtsH protease domain-like
  • 0Direct
    54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    54897,53187
  • 54897 - Protease propeptides/inhibitors
  • 53187 - Zn-dependent exopeptidases
  • 0Direct
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0Direct
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0Direct
    47587,56399
  • 47587 - Domain of poly(ADP-ribose) polymerase
  • 56399 - ADP-ribosylation
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    56112,82615
  • 56112 - Protein kinase-like (PK-like)
  • 82615 - Polo-box domain
  • 0Direct
    51338,51556
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 0Direct
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0Direct
    82615,82615
  • 82615 - Polo-box domain
  • 82615 - Polo-box domain
  • 0Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0Direct
    161093,161093
  • 161093 - MgtE membrane domain-like
  • 161093 - MgtE membrane domain-like
  • 0Direct
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0Direct
    52518,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0Direct
    55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    56601,48403
  • 56601 - beta-lactamase/transpeptidase-like
  • 48403 - Ankyrin repeat
  • 0Direct
    141739,141739
  • 141739 - MFPT repeat-like
  • 141739 - MFPT repeat-like
  • 0Direct
    48403,52151
  • 48403 - Ankyrin repeat
  • 52151 - FabD/lysophospholipase-like
  • 0Direct
    56059,52210
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52210 - Succinyl-CoA synthetase domains
  • 0Direct
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    57889,50729
  • 57889 - Cysteine-rich domain
  • 50729 - PH domain-like
  • 0Direct
    57938,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0Direct
    52518,52922
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 0Direct
    54211,55060
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55060 - GHMP Kinase, C-terminal domain
  • 0Direct
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0Direct
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0Direct
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0Direct
    49742,49742
  • 49742 - PHM/PNGase F
  • 49742 - PHM/PNGase F
  • 0Direct
    53187,55031
  • 53187 - Zn-dependent exopeptidases
  • 55031 - Bacterial exopeptidase dimerisation domain
  • 0Direct
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0Direct
    55326,56042
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 0Direct
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0Direct
    144232,82199
  • 144232 - HIT/MYND zinc finger-like
  • 82199 - SET domain
  • 0Direct
    81301,81631
  • 81301 - Nucleotidyltransferase
  • 81631 - PAP/OAS1 substrate-binding domain
  • 0Direct
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    51735,56327
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 56327 - LDH C-terminal domain-like
  • 0Direct
    74650,51445
  • 74650 - Galactose mutarotase-like
  • 51445 - (Trans)glycosidases
  • 0Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    81631,55003
  • 81631 - PAP/OAS1 substrate-binding domain
  • 55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain
  • 0Direct
    81698,81698
  • 81698 - FF domain
  • 81698 - FF domain
  • 0Direct
    57903,82199
  • 57903 - FYVE/PHD zinc finger
  • 82199 - SET domain
  • 0Direct
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.06691Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.08024Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.1021Inherited
    56112,55073
  • 56112 - Protein kinase-like (PK-like)
  • 55073 - Nucleotide cyclase
  • 0.1021Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.1649Inherited
    56436,49854
  • 56436 - C-type lectin-like
  • 49854 - Spermadhesin, CUB domain
  • 0.1868Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2021Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.2081Inherited
    51735,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0.2086Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.2086Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.2632Inherited
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.2632Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.2926Inherited
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.2959Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.3125Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.4064Inherited
    48403,48403
  • 48403 - Ankyrin repeat
  • 48403 - Ankyrin repeat
  • 0.4143Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 0.4303Inherited
    101690,53098
  • 101690 - PAZ domain
  • 53098 - Ribonuclease H-like
  • 0.517Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.517Inherited
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0.5736Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.5736Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.5881Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.6286Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.6394Inherited
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0.6394Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.714Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.7682Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.7785Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.7894Inherited
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.8991Inherited
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0.9Inherited
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0.9277Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.9957Inherited
    53300,56436
  • 53300 - vWA-like
  • 56436 - C-type lectin-like
  • 1Inherited
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 1Inherited
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 1Inherited
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    54928,54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0Direct
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    56112,82615,82615
  • 56112 - Protein kinase-like (PK-like)
  • 82615 - Polo-box domain
  • 82615 - Polo-box domain
  • 0Direct
    48452,48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0Direct
    82895,82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    53738,53738,53738
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 0Direct
    50249,50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    74650,51445,51011
  • 74650 - Galactose mutarotase-like
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0Direct
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0Direct
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    81301,81631,55003
  • 81301 - Nucleotidyltransferase
  • 81631 - PAP/OAS1 substrate-binding domain
  • 55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain
  • 0Direct
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0Direct
    55973,55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0Direct
    48726,49265,48726
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    57414,57414,57414
  • 57414 - Hairpin loop containing domain-like
  • 57414 - Hairpin loop containing domain-like
  • 57414 - Hairpin loop containing domain-like
  • 0Direct
    56436,49854,49854
  • 56436 - C-type lectin-like
  • 49854 - Spermadhesin, CUB domain
  • 49854 - Spermadhesin, CUB domain
  • 0Direct
    50156,50044,52540
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0Direct
    50044,50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0Direct
    57567,57567,57567
  • 57567 - Serine protease inhibitors
  • 57567 - Serine protease inhibitors
  • 57567 - Serine protease inhibitors
  • 0Direct
    51735,48179,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    57625,57625,57625
  • 57625 - Invertebrate chitin-binding proteins
  • 57625 - Invertebrate chitin-binding proteins
  • 57625 - Invertebrate chitin-binding proteins
  • 0Direct
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0Direct
    57938,49493,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    56645,47203,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    48371,48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    53738,53738,55957
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 55957 - Phosphoglucomutase, C-terminal domain
  • 0Direct
    54897,52743,49785
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0Direct
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    57362,57362,57362
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    46938,52087,101576
  • 46938 - CRAL/TRIO N-terminal domain
  • 52087 - CRAL/TRIO domain
  • 101576 - Supernatant protein factor (SPF), C-terminal domain
  • 0Direct
    54292,47741,56176
  • 54292 - 2Fe-2S ferredoxin-like
  • 47741 - CO dehydrogenase ISP C-domain like
  • 56176 - FAD-binding/transporter-associated domain-like
  • 0Direct
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.1153Inherited
    56436,56436,49854
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 49854 - Spermadhesin, CUB domain
  • 0.3182Inherited
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.3312Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.3312Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.4143Inherited
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.8109Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9165Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.9781Inherited


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