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Worm Phenotype (WP): organism homeostasis metabolism variant

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Variant [WBPhenotype:0000886] <2>
+ + 2:   physiology variant [WBPhenotype:0000519] <15>(509|582) (509|247|68)
+ 1:   organism physiology variant [WBPhenotype:0000576] <11>(366|425) (369|192|56)
0:   organism homeostasis metabolism variant [WBPhenotype:0000577] <16>(358|416) (360|189|55)
- 1:   organism metabolism processing variant [WBPhenotype:0000027] <25>(176|187) (179|86|26)
- 1:   organism environmental stimulus response variant [WBPhenotype:0000738] <16>(128|115) (130|52|16)
- 1:   RNAi response variant [WBPhenotype:0000743] <11>(8|10) (8|5|2)
- 1:   metal homeostasis variant [WBPhenotype:0002029] <6>(0|0) (0|0|0)
- 1:   growth variant [WBPhenotype:0000030] <5>(201|262) (203|115|38)
- 1:   maintenance of gene silencing variant [WBPhenotype:0002063] <4>(11|8) (11|2|0)
- 1:   hydrogen peroxide homeostasis variant [WBPhenotype:0002003] <2>(1|1) (1|0|0)
- 1:   osmotic integrity variant [WBPhenotype:0000041] <2>(6|7) (6|1|0)
- 1:   reactive oxygen species homeostasis variant [WBPhenotype:0002182] <2>(1|1) (1|0|0)
- 1:   ascaroside biosynthesis variant [WBPhenotype:0002051] <1>(2|2) (2|2|1)
- 1:   spontaneous mutation rate increased [WBPhenotype:0000228] <1>(6|5) (6|3|1)
- 1:   cation homeostasis variant [WBPhenotype:0002073](0|0) (0|0|0)
- 1:   hypersensitive to laser ablation [WBPhenotype:0001998](0|0) (0|0|0)
- 1:   hypersensitivity to mutagen [WBPhenotype:0001781](0|0) (0|0|0)
- 1:   protein signaling variant [WBPhenotype:0001207](0|0) (0|0|0)
- 1:   starved [WBPhenotype:0000547](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
CAD & PB1 domains0Direct
FtsH protease domain-like0Direct
Tubby C-terminal domain-like0Direct
TK C-terminal domain-like0Direct
Ribosomal protein L10Direct
RBP11-like subunits of RNA polymerase0Direct
Ribosomal proteins S24e, L23 and L15e0Direct
Heme-dependent catalase-like0Direct
Ferritin-like0Direct
Cullin repeat-like0Direct
LysM domain0Direct
Retrovirus zinc finger-like domains0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
Cystatin/monellin0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
CBD9-like0Direct
Galactose mutarotase-like0Direct
alpha-catenin/vinculin-like0Direct
AN1-like Zinc finger0Direct
MIR domain0Direct
Ribosomal protein S180Direct
Formate/glycerate dehydrogenase catalytic domain-like0Direct
Zn-finger domain of Sec23/240Direct
Thiolase-like0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
HRDC-like0Direct
Carbohydrate phosphatase0Direct
PLC-like phosphodiesterases0Direct
Integrin domains0Direct
ADP-ribosylation0Direct
GroEL equatorial domain-like0Direct
SAND domain-like0Direct
t-snare proteins0Direct
ArfGap/RecO-like zinc finger0Direct
R3H domain0Direct
Nucleotidyltransferase0Direct
ACP-like0Direct
Carbon-nitrogen hydrolase0Direct
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase0Direct
Nucleoside diphosphate kinase, NDK0Direct
Chromo domain-like0Direct
PGBD-like0Direct
Transducin (alpha subunit), insertion domain0Direct
ALDH-like0Direct
Proton glutamate symport protein0Direct
Ribosomal L27 protein-like0Direct
Cation efflux protein cytoplasmic domain-like0Direct
beta-lactamase/transpeptidase-like0Direct
Mitochondrial carrier0Direct
ISP domain0Direct
Aldolase0Direct
SIS domain0Direct
3-carboxy-cis,cis-mucoante lactonizing enzyme0Direct
PurM N-terminal domain-like0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
Galactose oxidase, central domain0Direct
Class I glutamine amidotransferase-like0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
MgtE membrane domain-like0Direct
Profilin (actin-binding protein)0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
ENTH/VHS domain0Direct
Families 57/38 glycoside transferase middle domain0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0Direct
Activating enzymes of the ubiquitin-like proteins0Direct
Succinyl-CoA synthetase domains0Direct
HSP90 C-terminal domain0Direct
WGR domain-like0Direct
cAMP-binding domain-like0Direct
CRAL/TRIO N-terminal domain0Direct
Acetyl-CoA synthetase-like0Direct
Doublecortin (DC)0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
eIF4e-like0Direct
Citrate synthase0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Terpenoid synthases0Direct
DNA repair protein MutS, domain III0Direct
Oxysterol-binding protein-like0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
F1F0 ATP synthase subunit C0Direct
LEM domain0Direct
PHM/PNGase F0Direct
Actin-like ATPase domain0Direct
PreATP-grasp domain0Direct
PLP-binding barrel0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
PK beta-barrel domain-like0Direct
Phoshotransferase/anion transport protein0Direct
VPS9 domain0Direct
Creatinase/prolidase N-terminal domain0Direct
Arginase/deacetylase0Direct
Surp module (SWAP domain)0Direct
Complement control module/SCR domain0Direct
SWIB/MDM2 domain0Direct
Spectrin repeat0Direct
L30e-like0Direct
SPOC domain-like0Direct
Phosphoglucomutase, first 3 domains0Direct
Tim10-like0Direct
Skp1 dimerisation domain-like0Direct
FAD-linked oxidases, C-terminal domain0Direct
Rap/Ran-GAP0Direct
PIN domain-like0Direct
BEACH domain0Direct
DEATH domain0Direct
YWTD domain0Direct
S-adenosylmethionine synthetase0Direct
YbiA-like0Direct
Single hybrid motif0Direct
Lipovitellin-phosvitin complex, superhelical domain0Direct
Nucleoporin domain0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
MFPT repeat-like0Direct
GAS2 domain-like0Direct
Terpenoid cyclases/Protein prenyltransferases0Direct
SMAD MH1 domain0Direct
PEP carboxykinase N-terminal domain0Direct
Tricorn protease domain 20Direct
Hormone receptor domain0Direct
GroEL-intermediate domain like0Direct
Sec1/munc18-like (SM) proteins0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Band 7/SPFH domain0Direct
ARID-like0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
GAT-like domain0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Transducin (heterotrimeric G protein), gamma chain0Direct
alpha/beta knot0Direct
Sec63 N-terminal domain-like0Direct
Sec7 domain0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Phosphoenolpyruvate/pyruvate domain0Direct
14-3-3 protein0Direct
Nop domain0Direct
Tubulin nucleotide-binding domain-like0Direct
LDH C-terminal domain-like0Direct
Carboxypeptidase regulatory domain-like0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Cytochrome c0Direct
Blood coagulation inhibitor (disintegrin)0Direct
PAP/OAS1 substrate-binding domain0Direct
Helical domain of Sec23/240Direct
Subtilisin-like0Direct
GroES-like0Direct
Pepsin inhibitor-30Direct
Small-conductance potassium channel0Direct
HSP20-like chaperones0Direct
Hypothetical protein c14orf129, hspc2100Direct
Integrin alpha N-terminal domain0Direct
lambda repressor-like DNA-binding domains0Direct
2Fe-2S ferredoxin-like0Direct
HSP40/DnaJ peptide-binding domain0Direct
Cdc48 domain 2-like0Direct
Thyroglobulin type-1 domain0Direct
Phosphoglucomutase, C-terminal domain0Direct
PABC (PABP) domain0Direct
Heme-dependent peroxidases0Direct
SAICAR synthase-like0Direct
Restriction endonuclease-like0Direct
Chitinase insertion domain0Direct
Clathrin adaptor appendage domain0Direct
Ran binding protein zinc finger-like0Direct
Cu,Zn superoxide dismutase-like0Direct
Radical SAM enzymes0Direct
Ribosomal protein L10-like0Direct
Glycolipid transfer protein, GLTP0Direct
Clc chloride channel0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
Tubulin C-terminal domain-like0Direct
Smc hinge domain0Direct
PYP-like sensor domain (PAS domain)0Direct
Bacterial exopeptidase dimerisation domain0Direct
Periplasmic binding protein-like II0Direct
Chaperone J-domain0Direct
Ribulose-phoshate binding barrel0Direct
Annexin0Direct
HCP-like0Direct
Class II aaRS ABD-related0Direct
PEBP-like0Direct
Putative DNA-binding domain0Direct
WWE domain0Direct
JAB1/MPN domain0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
Pentein0Direct
FAD-dependent thiol oxidase0Direct
FAD-binding/transporter-associated domain-like0Direct
Hedgehog/intein (Hint) domain0Direct
Lamin A/C globular tail domain0Direct
PurM C-terminal domain-like0Direct
Ribosomal protein S100Direct
Intermediate filament protein, coiled coil region0Direct
Molybdenum cofactor-binding domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
GroEL apical domain-like0Direct
Domain of poly(ADP-ribose) polymerase0Direct
Second domain of FERM0Direct
Fibrinogen C-terminal domain-like0Direct
Glutathione synthetase ATP-binding domain-like0Direct
GYF domain0Direct
Composite domain of metallo-dependent hydrolases0Direct
Zn-binding ribosomal proteins0Direct
Histone-fold0Direct
Acid phosphatase/Vanadium-dependent haloperoxidase0Direct
PEP carboxykinase-like0Direct
TGS-like0Direct
Diaminopimelate epimerase-like0Direct
Troponin coil-coiled subunits0Direct
MOSC N-terminal domain-like0Direct
FF domain0Direct
Ribokinase-like0Direct
Polo-box domain0Direct
ThrRS/AlaRS common domain0Direct
Protease propeptides/inhibitors0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
CO dehydrogenase ISP C-domain like0Direct
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)0Direct
Translational machinery components0Direct
Invertebrate chitin-binding proteins0Direct
Rudiment single hybrid motif0Direct
L-aspartase-like0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Outer arm dynein light chain 10Direct
ValRS/IleRS/LeuRS editing domain0Direct
Cullin homology domain0Direct
Elafin-like0Direct
Cadherin-like0Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
NagB/RpiA/CoA transferase-like0Direct
PH domain-like0.00001205Direct
PDZ domain-like0.00699Inherited
TPR-like0.009418Inherited
ARM repeat0.01247Inherited
ABC transporter transmembrane region0.01693Inherited
Homeodomain-like0.0398Inherited
WD40 repeat-like0.04644Inherited
CCCH zinc finger0.06143Inherited
"Winged helix" DNA-binding domain0.07677Inherited
Translation proteins0.07728Inherited
Ankyrin repeat0.08236Inherited
HLH, helix-loop-helix DNA-binding domain0.08823Inherited
SMAD/FHA domain0.0971Inherited
SH3-domain0.1066Inherited
Calcium ATPase, transmembrane domain M0.1089Inherited
EGF/Laminin0.116Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.122Inherited
Regulator of G-protein signaling, RGS0.122Inherited
Calcium ATPase, transduction domain A0.1367Inherited
Acid proteases0.1367Inherited
Cysteine-rich domain0.1406Inherited
Quinoprotein alcohol dehydrogenase-like0.1528Inherited
Multidrug efflux transporter AcrB transmembrane domain0.1539Inherited
Cytochrome P4500.1571Inherited
(Trans)glycosidases0.1671Inherited
ClpP/crotonase0.171Inherited
DBL homology domain (DH-domain)0.171Inherited
HMG-box0.171Inherited
Cysteine proteinases0.2108Inherited
P-loop containing nucleoside triphosphate hydrolases0.2128Inherited
POZ domain0.2149Inherited
Cyclin-like0.2189Inherited
RNA-binding domain, RBD0.2317Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.2381Inherited
Bromodomain0.2381Inherited
Tudor/PWWP/MBT0.2381Inherited
Metallo-dependent phosphatases0.2499Inherited
Protein kinase-like (PK-like)0.2563Inherited
Lipocalins0.2591Inherited
SNARE-like0.2654Inherited
Cation efflux protein transmembrane domain-like0.3291Inherited
PX domain0.3291Inherited
Nicotinic receptor ligand binding domain-like0.3317Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3714Inherited
RNI-like0.3878Inherited
FKBP-like0.4062Inherited
HD-domain/PDEase-like0.4062Inherited
Class II aaRS and biotin synthetases0.4157Inherited
DHS-like NAD/FAD-binding domain0.4496Inherited
Myosin rod fragments0.4496Inherited
PRTase-like0.4496Inherited
Hect, E3 ligase catalytic domain0.4496Inherited
Galactose-binding domain-like0.4682Inherited
SH2 domain0.4685Inherited
Cystine-knot cytokines0.4813Inherited
WW domain0.4813Inherited
Sm-like ribonucleoproteins0.4813Inherited
Voltage-gated potassium channels0.4921Inherited
Calpain large subunit, middle domain (domain III)0.4985Inherited
Riboflavin synthase domain-like0.4985Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.4985Inherited
UBC-like0.5157Inherited
SAM/Pointed domain0.5175Inherited
Seven-hairpin glycosidases0.5531Inherited
Multidrug resistance efflux transporter EmrE0.5539Inherited
PLP-dependent transferases0.5611Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.5725Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.6017Inherited
Di-copper centre-containing domain0.6092Inherited
KA1-like0.6092Inherited
HIT/MYND zinc finger-like0.6287Inherited
GST C-terminal domain-like0.6524Inherited
4Fe-4S ferredoxins0.6743Inherited
S15/NS1 RNA-binding domain0.6743Inherited
Frizzled cysteine-rich domain0.6743Inherited
alpha/beta-Hydrolases0.6887Inherited
ADC-like0.7455Inherited
MIT domain0.7455Inherited
Clavaminate synthase-like0.7871Inherited
PapD-like0.7978Inherited
NAD kinase/diacylglycerol kinase-like0.7997Inherited
Cyclophilin-like0.8052Inherited
CoA-dependent acyltransferases0.8052Inherited
EF-hand0.8329Inherited
SNF-like0.8352Inherited
Leucine zipper domain0.8386Inherited
GTPase activation domain, GAP0.8443Inherited
Thioredoxin-like0.8539Inherited
Ubiquitin-like0.8751Inherited
Immunoglobulin0.8843Inherited
p53-like transcription factors0.8878Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.8938Inherited
Nucleic acid-binding proteins0.9151Inherited
Ribonuclease PH domain 2-like0.923Inherited
FYVE/PHD zinc finger0.9313Inherited
HAD-like0.9397Inherited
MFS general substrate transporter0.9441Inherited
Saposin0.9442Inherited
Periplasmic binding protein-like I0.9622Inherited
FAD/NAD(P)-binding domain0.9622Inherited
Nucleotide cyclase0.9731Inherited
PAZ domain0.9805Inherited
Ribosomal protein S5 domain 2-like0.9808Inherited
SET domain0.9857Inherited
Ligand-binding domain in the NO signalling and Golgi transport0.9941Inherited
E set domains1Inherited
RING/U-box1Inherited
Nuclear receptor ligand-binding domain1Inherited
UBA-like1Inherited
DNA/RNA polymerases1Inherited
Acyl-CoA dehydrogenase C-terminal domain-like1Inherited
Bet v1-like1Inherited
Ribonuclease H-like1Inherited
dsRNA-binding domain-like1Inherited
Insulin-like1Inherited
B-box zinc-binding domain1Inherited
Nucleotidylyl transferase1Inherited
Translation proteins SH3-like domain1Inherited
F-box domain1Inherited
Snake toxin-like1Inherited
Acyl-CoA dehydrogenase NM domain-like1Inherited
Family A G protein-coupled receptor-like1Inherited
BRCT domain1Inherited
beta-beta-alpha zinc fingers1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Ribosomal protein S100Direct
Transducin (heterotrimeric G protein), gamma chain0Direct
RNA-polymerase beta-prime0Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
Sec7 domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Armadillo repeat0Direct
Clc chloride channel0Direct
Troponin I0Direct
Phosphoglucomutase, first 3 domains0Direct
MutT-like0Direct
Matrix metalloproteases, catalytic domain0Direct
COMT-like0Direct
Thiolase-related0Direct
Type II chitinase0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Sir2 family of transcriptional regulators0Direct
POU-specific domain0Direct
Glycosyl transferases group 10Direct
alpha-mannosidase0Direct
YihX-like0Direct
Domain of poly(ADP-ribose) polymerase0Direct
NTF2-like0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Protein prenyltransferases0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Paired domain0Direct
VHS domain0Direct
GYF domain0Direct
AMPK-beta glycogen binding domain-like0Direct
U-box0Direct
D-aminoacid oxidase-like0Direct
ALDH-like0Direct
Proprotein convertase P-domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
ValRS/IleRS/LeuRS editing domain0Direct
Hydantoinase (dihydropyrimidinase), catalytic domain0Direct
beta-Lactamase/D-ala carboxypeptidase0Direct
Pumilio repeat0Direct
alpha-catenin/vinculin0Direct
Band 7/SPFH domain0Direct
Hexokinase0Direct
Oxysterol-binding protein0Direct
DPP6 catalytic domain-like0Direct
5' to 3' exonuclease catalytic domain0Direct
Cofilin-like0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Acetyl-CoA synthetase-like0Direct
Hypothetical protein c14orf129, hspc2100Direct
CO dehydrogenase flavoprotein N-terminal domain-like0Direct
Gamma-glutamyltranspeptidase-like0Direct
LysM domain0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
Chitinase insertion domain0Direct
Ran binding protein zinc finger-like0Direct
Brix domain0Direct
Mitochondrial carrier0Direct
NHL repeat0Direct
Proteasome subunits0Direct
Group II chaperonin (CCT, TRIC), ATPase domain0Direct
Group II chaperonin (CCT, TRIC), apical domain0Direct
Inositol monophosphatase/fructose-1,6-bisphosphatase-like0Direct
Ribosomal protein L18 and S110Direct
Dual specificity phosphatase-like0Direct
SAM (sterile alpha motif) domain0Direct
Thyroglobulin type-1 domain0Direct
HSP40/DnaJ peptide-binding domain0Direct
Ribokinase-like0Direct
Poly(ADP-ribose) polymerase, C-terminal domain0Direct
Nucleosome core histones0Direct
Actin/HSP700Direct
HSP90 C-terminal domain0Direct
Intermediate filament protein, coiled coil region0Direct
Clathrin coat assembly domain0Direct
SMAD MH1 domain0Direct
Hsp90 middle domain0Direct
GAS2 domain0Direct
Lactate & malate dehydrogenases, C-terminal domain0Direct
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)0Direct
Spectrin repeat0Direct
PurM C-terminal domain-like0Direct
RecA protein-like (ATPase-domain)0Direct
Second domain of FERM0Direct
CoA-binding domain0Direct
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta0Direct
NOL1/NOP2/sun0Direct
PEP carboxykinase N-terminal domain0Direct
IF2B-like0Direct
Cytoplasmic domain of inward rectifier potassium channel0Direct
Profilin (actin-binding protein)0Direct
LEM domain0Direct
Choline kinase0Direct
DEP domain0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain0Direct
Citrate synthase0Direct
Pancreatic carboxypeptidases0Direct
Phosphatidylethanolamine binding protein0Direct
BAR domain0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
Histone deacetylase, HDAC0Direct
RhoGDI-like0Direct
CoA transferase alpha subunit-like0Direct
Phosphoribosyltransferases (PRTases)0Direct
Reductases0Direct
Retrovirus zinc finger-like domains0Direct
beta 1,4 galactosyltransferase (b4GalT1)0Direct
Hedgehog C-terminal (Hog) autoprocessing domain0Direct
beta-sandwich domain of Sec23/240Direct
Clathrin adaptor core protein0Direct
Vertebrate phospholipase A20Direct
TBP-associated factors, TAFs0Direct
Alcohol dehydrogenase-like, N-terminal domain0Direct
CUT domain0Direct
Sec63 N-terminal domain0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
SWIRM domain0Direct
Translation initiation factor eIF4e0Direct
Tetraspanin0Direct
Calpain large subunit, catalytic domain (domain II)0Direct
PUA domain0Direct
YicI catalytic domain-like0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0Direct
Doublecortin (DC)0Direct
DNA repair protein MutS, domain III0Direct
UBA domain0Direct
Quinoprotein alcohol dehydrogenase-like0Direct
PLC-like (P variant)0Direct
Carboxypeptidase regulatory domain0Direct
Myotubularin-like phosphatases0Direct
acyl-CoA oxidase C-terminal domains0Direct
CRAL/TRIO N-terminal domain0Direct
Rap/Ran-GAP0Direct
Polo-box duplicated region0Direct
Integrin domains0Direct
PDI-like0Direct
RNA editing terminal uridyl transferase 2, RET2, domain 20Direct
HAT/Suf repeat0Direct
Regulator of chromosome condensation RCC10Direct
Surp module (SWAP domain)0Direct
Ribosomal protein S180Direct
Phosphate binding protein-like0Direct
Linker histone H1/H50Direct
PhzC/PhzF-like0Direct
Smc hinge domain0Direct
Fibrinogen C-terminal domain-like0Direct
Arylsulfatase0Direct
SAND domain0Direct
p120GAP domain-like0Direct
Nucleoside diphosphate kinase, NDK0Direct
HD domain0Direct
Reprolysin-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Phosphotyrosine-binding domain (PTB)0Direct
WGR domain0Direct
Pyk2-associated protein beta ARF-GAP domain0Direct
Calcium ATPase, transmembrane domain M0Direct
MIF4G domain-like0Direct
Glycogenin0Direct
Glycolipid transfer protein, GLTP0Direct
Pepsin inhibitor-30Direct
L30e/L7ae ribosomal proteins0Direct
Eps15 homology domain (EH domain)0Direct
Cdc48 domain 2-like0Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
CAT-like0Direct
Tubulin, GTPase domain0Direct
Hydantoinase (dihydropyrimidinase)0Direct
Fatty acid binding protein-like0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain0Direct
FAD-dependent thiol oxidase0Direct
DEATH domain, DD0Direct
Annexin0Direct
Class I aldolase0Direct
Erythroid transcription factor GATA-10Direct
Cadherin0Direct
Lamin A/C globular tail domain0Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
Zn-finger domain of Sec23/240Direct
Sec63 C-terminal domain-like0Direct
Ribosomal protein L10Direct
D-aminoacid oxidase, N-terminal domain0Direct
Peptidylglycine alpha-hydroxylating monooxygenase, PHM0Direct
F1F0 ATP synthase subunit C0Direct
MOSC N-terminal domain-like0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
Class II glutamine amidotransferases0Direct
HEAT repeat0Direct
a tRNA synthase domain0Direct
Nop domain0Direct
Sec1/munc18-like (SM) proteins0Direct
PaaI/YdiI-like0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Tubulin, C-terminal domain0Direct
PABC (PABP) domain0Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
Bactericidal permeability-increasing protein, BPI0Direct
PDZ domain0Direct
alpha-mannosidase, domain 20Direct
Branched-chain alpha-keto acid dehydrogenase Pyr module0Direct
Elafin-like0Direct
Biotinyl/lipoyl-carrier proteins and domains0Direct
14-3-3 protein0Direct
AN1-like Zinc finger0Direct
Ngr ectodomain-like0Direct
Helical domain of Sec23/240Direct
Aminoacid dehydrogenase-like, C-terminal domain0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
Succinyl-CoA synthetase domains0Direct
Internalin LRR domain0Direct
Ubiquitin activating enzymes (UBA)0Direct
Formate/glycerate dehydrogenases, NAD-domain0Direct
GAPDH-like0Direct
1,3-glucuronyltransferase0Direct
Chaperone J-domain0Direct
Class I glutamine amidotransferases (GAT)0Direct
SCF ubiquitin ligase complex WHB domain0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Molybdenum cofactor-binding domain0Direct
PDEase0Direct
ATP-dependent protease Lon (La), catalytic domain0Direct
Trunk domain of Sec23/240Direct
UDP-glucose pyrophosphorylase0Direct
Biotin dependent carboxylase carboxyltransferase domain0Direct
Regulator of G-protein signaling, RGS0Direct
Ras-binding domain, RBD0Direct
Acyl-CoA thioesterase0Direct
Myeloperoxidase-like0Direct
CO dehydrogenase ISP C-domain like0Direct
Acireductone dioxygenase0Direct
Alcohol dehydrogenase-like, C-terminal domain0Direct
LacY-like proton/sugar symporter0Direct
Lesion bypass DNA polymerase (Y-family), catalytic domain0Direct
Pancreatic carboxypeptidase, activation domain0Direct
Blood coagulation inhibitor (disintegrin)0Direct
HSP200Direct
alpha-mannosidase, C-terminal domain0Direct
RNA-polymerase beta0Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0Direct
Skp1 dimerisation domain-like0Direct
Pleckstrin-homology domain (PH domain)0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
S-adenosylmethionine synthetase0Direct
Branched-chain alpha-keto acid dehydrogenase PP module0Direct
Transducin (alpha subunit), insertion domain0Direct
HCDH C-domain-like0Direct
28-residue LRR0Direct
FtsH protease domain-like0Direct
SWIB/MDM2 domain0Direct
MFPT repeat0Direct
Subtilases0Direct
BC N-terminal domain-like0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
MIR domain0Direct
Small-conductance potassium channel0Direct
Cation efflux protein cytoplasmic domain-like0Direct
Arfaptin, Rac-binding fragment0Direct
Lipovitellin-phosvitin complex, superhelical domain0Direct
Third domain of FERM0Direct
BC C-terminal domain-like0Direct
YbiA-like0Direct
Glycerol kinase0Direct
PurM N-terminal domain-like0Direct
L-aminoacid/polyamine oxidase0Direct
BEACH domain0Direct
BC ATP-binding domain-like0Direct
DPP6 N-terminal domain-like0Direct
SMAD domain0Direct
Acylamino-acid-releasing enzyme, C-terminal donain0Direct
Glycerophosphoryl diester phosphodiesterase0Direct
WWE domain0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
Methionine aminopeptidase, insert domain0Direct
Anticodon-binding domain0Direct
Cullin homology domain0Direct
Tim10/DDP0Direct
Chromo domain0Direct
FF domain0Direct
t-snare proteins0Direct
Anticodon-binding domain of Class II aaRS0Direct
FHA domain0Direct
Acyl-carrier protein (ACP)0Direct
Arginine methyltransferase0Direct
Amylase, catalytic domain0Direct
PEP carboxykinase C-terminal domain0Direct
First domain of FERM0Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0Direct
Hormone receptor domain0Direct
ARID domain0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
La domain0Direct
Adenain-like0Direct
Cullin repeat0Direct
Heme-dependent catalases0Direct
Epoxide hydrolase0Direct
Laminin G-like module0Direct
2Fe-2S ferredoxin domains from multidomain proteins0Direct
LDH N-terminal domain-like0Direct
Inositol polyphosphate kinase (IPK)0Direct
YWTD domain0Direct
cAMP-binding domain0Direct
Cu,Zn superoxide dismutase-like0Direct
Complement control module/SCR domain0Direct
Cell cycle control phosphatase, catalytic domain0Direct
ets domain0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Glutaminase0Direct
Proton glutamate symport protein0Direct
Mammalian PLC0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain0Direct
Translational machinery components0Direct
Bacterial exopeptidase dimerisation domain0Direct
acyl-CoA oxidase N-terminal domains0Direct
Single strand DNA-binding domain, SSB0Direct
ABC transporter ATPase domain-like0.0008708Direct
Tandem AAA-ATPase domain0.002492Inherited
Homeodomain0.02712Inherited
G proteins0.0321Inherited
WD40-repeat0.03341Inherited
ABC transporter transmembrane region0.03552Inherited
Canonical RBD0.06844Inherited
CCCH zinc finger0.07483Inherited
Extended AAA-ATPase domain0.08806Inherited
Tetratricopeptide repeat (TPR)0.09601Inherited
Motor proteins0.1139Inherited
HLH, helix-loop-helix DNA-binding domain0.1139Inherited
Ankyrin repeat0.1399Inherited
SH3-domain0.1512Inherited
Calcium ATPase, transduction domain A0.1554Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.1912Inherited
Elongation factors0.1912Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.1912Inherited
DBL homology domain (DH-domain)0.1912Inherited
Cyclin0.1912Inherited
HMG-box0.1912Inherited
Pepsin-like0.212Inherited
Cytochrome P4500.228Inherited
Forkhead DNA-binding domain0.2348Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.2348Inherited
Multidrug efflux transporter AcrB transmembrane domain0.2383Inherited
Protein kinases, catalytic subunit0.2491Inherited
Acetylcholinesterase-like0.2566Inherited
Bromodomain0.26Inherited
6-phosphogluconate dehydrogenase-like, N-terminal domain0.26Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.2748Inherited
FAD/NAD-linked reductases, N-terminal and central domains0.2872Inherited
Meta-cation ATPase, catalytic domain P0.318Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP0.318Inherited
Crotonase-like0.318Inherited
PX domain0.3514Inherited
BTB/POZ domain0.3824Inherited
GABA-aminotransferase-like0.3873Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.3999Inherited
FKBP immunophilin/proline isomerase0.4272Inherited
Cation efflux protein transmembrane domain-like0.4272Inherited
PHD domain0.429Inherited
Glutathione S-transferase (GST), N-terminal domain0.4507Inherited
Nicotinic receptor ligand binding domain-like0.4596Inherited
Pyridoxal-dependent decarboxylase0.4701Inherited
Hect, E3 ligase catalytic domain0.4701Inherited
I set domains0.4892Inherited
Papain-like0.4928Inherited
Calpain large subunit, middle domain (domain III)0.5176Inherited
Gastric lipase0.5176Inherited
Myb/SANT domain0.5176Inherited
WW domain0.5225Inherited
UBC-related0.5455Inherited
Class I alpha-1;2-mannosidase, catalytic domain0.5672Inherited
SH2 domain0.5687Inherited
Synaptotagmin-like (S variant)0.5904Inherited
Ubiquitin carboxyl-terminal hydrolase, UCH0.6323Inherited
Frizzled cysteine-rich domain0.6873Inherited
Transforming growth factor (TGF)-beta0.6873Inherited
EF-hand modules in multidomain proteins0.6873Inherited
Ubiquitin-related0.7104Inherited
Voltage-gated potassium channels0.7399Inherited
H-NOX domain0.7546Inherited
Cdc48 N-terminal domain-like0.7546Inherited
Hemocyanin middle domain0.7546Inherited
Bacterial lipase0.7546Inherited
MIT domain0.7546Inherited
MSP-like0.7902Inherited
AAT-like0.8211Inherited
LIM domain0.8211Inherited
Cyclophilin (peptidylprolyl isomerase)0.8383Inherited
Glutathione S-transferase (GST), C-terminal domain0.8571Inherited
Calmodulin-like0.8683Inherited
Leucine zipper domain0.8773Inherited
SNF-like0.8928Inherited
Extended PAW domain0.8928Inherited
Ribonuclease PH domain 1-like0.9342Inherited
Ribonuclease PH domain 2-like0.9342Inherited
Adenylyl and guanylyl cyclase catalytic domain0.9478Inherited
L-arabinose binding protein-like0.9677Inherited
Choline/Carnitine O-acyltransferase0.9868Inherited
Cold shock DNA-binding domain-like0.9947Inherited
RING finger domain, C3HC41Inherited
PAZ domain1Inherited
FYVE, a phosphatidylinositol-3-phosphate binding domain1Inherited
F-box domain1Inherited
Histone lysine methyltransferases1Inherited
Double-stranded RNA-binding domain (dsRBD)1Inherited
Insulin-like1Inherited
Nuclear receptor ligand-binding domain1Inherited
B-box zinc-binding domain1Inherited
Glutathione peroxidase-like1Inherited
Rhodopsin-like1Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains1Inherited
DnaQ-like 3'-5' exonuclease1Inherited
N-acetyl transferase, NAT1Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain1Inherited
Nuclear receptor1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Radical SAM enzymes0Direct
Nop domain0Direct
Cadherin-like0Direct
Cullin repeat-like0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
SMAD MH1 domain0Direct
Lamin A/C globular tail domain0Direct
AN1-like Zinc finger0Direct
Spectrin repeat0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
Hormone receptor domain0Direct
ACP-like0Direct
PEP carboxykinase N-terminal domain0Direct
FF domain0Direct
HCP-like0Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
WWE domain0Direct
Phosphoglucomutase, C-terminal domain0Direct
alpha-catenin/vinculin-like0Direct
Nucleoside diphosphate kinase, NDK0Direct
Helical domain of Sec23/240Direct
Zn-binding ribosomal proteins0Direct
Tricorn protease domain 20Direct
DEATH domain0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
Galactose mutarotase-like0Direct
Phosphoenolpyruvate/pyruvate domain0Direct
Ribokinase-like0Direct
Band 7/SPFH domain0Direct
GroEL apical domain-like0Direct
Surp module (SWAP domain)0Direct
Cdc48 domain 2-like0Direct
Ribulose-phoshate binding barrel0Direct
ArfGap/RecO-like zinc finger0Direct
MIR domain0Direct
CAD & PB1 domains0Direct
Hedgehog/intein (Hint) domain0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Glutathione synthetase ATP-binding domain-like0Direct
TK C-terminal domain-like0Direct
FAD-dependent thiol oxidase0Direct
ADP-ribosylation0Direct
LDH C-terminal domain-like0Direct
Single hybrid motif0Direct
Galactose oxidase, central domain0Direct
Ribosomal protein L10Direct
PGBD-like0Direct
Second domain of FERM0Direct
MgtE membrane domain-like0Direct
Ribosomal protein S100Direct
Phosphoglucomutase, first 3 domains0Direct
Ferritin-like0Direct
Tubby C-terminal domain-like0Direct
Restriction endonuclease-like0Direct
SWIB/MDM2 domain0Direct
Chromo domain-like0Direct
Cu,Zn superoxide dismutase-like0Direct
Chitinase insertion domain0Direct
Zn-finger domain of Sec23/240Direct
Oxysterol-binding protein-like0Direct
PYP-like sensor domain (PAS domain)0Direct
t-snare proteins0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
MOSC N-terminal domain-like0Direct
PHM/PNGase F0Direct
PABC (PABP) domain0Direct
Clc chloride channel0Direct
Phoshotransferase/anion transport protein0Direct
SAND domain-like0Direct
GroES-like0Direct
Families 57/38 glycoside transferase middle domain0Direct
Ran binding protein zinc finger-like0Direct
JAB1/MPN domain0Direct
Clathrin adaptor appendage domain0Direct
ENTH/VHS domain0Direct
FtsH protease domain-like0Direct
ALDH-like0Direct
Histone-fold0Direct
PurM N-terminal domain-like0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
HSP90 C-terminal domain0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
LysM domain0Direct
Acetyl-CoA synthetase-like0Direct
PreATP-grasp domain0Direct
Cullin homology domain0Direct
HSP20-like chaperones0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Thyroglobulin type-1 domain0Direct
Domain of poly(ADP-ribose) polymerase0Direct
Integrin alpha N-terminal domain0Direct
ThrRS/AlaRS common domain0Direct
DNA repair protein MutS, domain III0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Polo-box domain0Direct
Class I glutamine amidotransferase-like0Direct
MFPT repeat-like0Direct
Tubulin C-terminal domain-like0Direct
Troponin coil-coiled subunits0Direct
Sec7 domain0Direct
NagB/RpiA/CoA transferase-like0Direct
Pepsin inhibitor-30Direct
cAMP-binding domain-like0Direct
PK beta-barrel domain-like0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Cystatin/monellin0Direct
Molybdenum cofactor-binding domain0Direct
GAT-like domain0Direct
F1F0 ATP synthase subunit C0Direct
R3H domain0Direct
eIF4e-like0Direct
Thiolase-like0Direct
Ribosomal L27 protein-like0Direct
S-adenosylmethionine synthetase0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
Ribosomal protein L10-like0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Ribosomal proteins S24e, L23 and L15e0Direct
Smc hinge domain0Direct
L30e-like0Direct
Skp1 dimerisation domain-like0Direct
3-carboxy-cis,cis-mucoante lactonizing enzyme0Direct
Ribosomal protein S180Direct
Doublecortin (DC)0Direct
Profilin (actin-binding protein)0Direct
Rap/Ran-GAP0Direct
Heme-dependent peroxidases0Direct
Invertebrate chitin-binding proteins0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
CBD9-like0Direct
GYF domain0Direct
Actin-like ATPase domain0Direct
Transducin (heterotrimeric G protein), gamma chain0Direct
Diaminopimelate epimerase-like0Direct
Transducin (alpha subunit), insertion domain0Direct
SAICAR synthase-like0Direct
Nucleoporin domain0Direct
Terpenoid cyclases/Protein prenyltransferases0Direct
PEP carboxykinase-like0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
Hypothetical protein c14orf129, hspc2100Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0Direct
Aldolase0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Mitochondrial carrier0Direct
Rudiment single hybrid motif0Direct
YWTD domain0Direct
RBP11-like subunits of RNA polymerase0Direct
Protease propeptides/inhibitors0Direct
YbiA-like0Direct
Citrate synthase0Direct
GroEL equatorial domain-like0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
Intermediate filament protein, coiled coil region0Direct
PIN domain-like0Direct
PurM C-terminal domain-like0Direct
SPOC domain-like0Direct
Activating enzymes of the ubiquitin-like proteins0Direct
Blood coagulation inhibitor (disintegrin)0Direct
CRAL/TRIO N-terminal domain0Direct
L-aspartase-like0Direct
ARID-like0Direct
HSP40/DnaJ peptide-binding domain0Direct
Composite domain of metallo-dependent hydrolases0Direct
VPS9 domain0Direct
Periplasmic binding protein-like II0Direct
LEM domain0Direct
Proton glutamate symport protein0Direct
Class II aaRS ABD-related0Direct
Complement control module/SCR domain0Direct
Fibrinogen C-terminal domain-like0Direct
Cation efflux protein cytoplasmic domain-like0Direct
Carbon-nitrogen hydrolase0Direct
FAD-binding/transporter-associated domain-like0Direct
lambda repressor-like DNA-binding domains0Direct
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
Small-conductance potassium channel0Direct
Creatinase/prolidase N-terminal domain0Direct
GroEL-intermediate domain like0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
HRDC-like0Direct
GAS2 domain-like0Direct
Acid phosphatase/Vanadium-dependent haloperoxidase0Direct
BEACH domain0Direct
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)0Direct
PEBP-like0Direct
PAP/OAS1 substrate-binding domain0Direct
Outer arm dynein light chain 10Direct
2Fe-2S ferredoxin-like0Direct
ISP domain0Direct
Bacterial exopeptidase dimerisation domain0Direct
PLC-like phosphodiesterases0Direct
beta-lactamase/transpeptidase-like0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
Elafin-like0Direct
Chaperone J-domain0Direct
Putative DNA-binding domain0Direct
Formate/glycerate dehydrogenase catalytic domain-like0Direct
WGR domain-like0Direct
alpha/beta knot0Direct
Tubulin nucleotide-binding domain-like0Direct
Arginase/deacetylase0Direct
Pentein0Direct
Nucleotidyltransferase0Direct
Retrovirus zinc finger-like domains0Direct
Integrin domains0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
SIS domain0Direct
CO dehydrogenase ISP C-domain like0Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
TGS-like0Direct
Sec1/munc18-like (SM) proteins0Direct
Annexin0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Terpenoid synthases0Direct
14-3-3 protein0Direct
Carbohydrate phosphatase0Direct
Lipovitellin-phosvitin complex, superhelical domain0Direct
Tim10-like0Direct
PLP-binding barrel0Direct
Carboxypeptidase regulatory domain-like0Direct
Translational machinery components0Direct
Sec63 N-terminal domain-like0Direct
Subtilisin-like0Direct
Glycolipid transfer protein, GLTP0Direct
Succinyl-CoA synthetase domains0Direct
Cytochrome c0Direct
Heme-dependent catalase-like0Direct
FAD-linked oxidases, C-terminal domain0Direct
PH domain-like0.000009829Direct
PDZ domain-like0.00598Inherited
TPR-like0.008102Inherited
ARM repeat0.01078Inherited
ABC transporter transmembrane region0.01469Inherited
Homeodomain-like0.03516Inherited
WD40 repeat-like0.04115Inherited
CCCH zinc finger0.05477Inherited
"Winged helix" DNA-binding domain0.06887Inherited
Translation proteins0.06933Inherited
Ankyrin repeat0.07404Inherited
HLH, helix-loop-helix DNA-binding domain0.07951Inherited
SMAD/FHA domain0.08771Inherited
SH3-domain0.09649Inherited
Calcium ATPase, transmembrane domain M0.09862Inherited
EGF/Laminin0.1052Inherited
Regulator of G-protein signaling, RGS0.1107Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.1107Inherited
Calcium ATPase, transduction domain A0.1245Inherited
Acid proteases0.1245Inherited
Cysteine-rich domain0.1282Inherited
Quinoprotein alcohol dehydrogenase-like0.1396Inherited
Multidrug efflux transporter AcrB transmembrane domain0.1406Inherited
Cytochrome P4500.1437Inherited
(Trans)glycosidases0.1532Inherited
DBL homology domain (DH-domain)0.1569Inherited
HMG-box0.1569Inherited
ClpP/crotonase0.1569Inherited
Cysteine proteinases0.1945Inherited
P-loop containing nucleoside triphosphate hydrolases0.1965Inherited
POZ domain0.1985Inherited
Cyclin-like0.2024Inherited
RNA-binding domain, RBD0.2146Inherited
Bromodomain0.2208Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.2208Inherited
Tudor/PWWP/MBT0.2208Inherited
Metallo-dependent phosphatases0.2321Inherited
Protein kinase-like (PK-like)0.2384Inherited
Lipocalins0.2412Inherited
SNARE-like0.2473Inherited
Cation efflux protein transmembrane domain-like0.3095Inherited
PX domain0.3095Inherited
Nicotinic receptor ligand binding domain-like0.312Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.351Inherited
RNI-like0.3672Inherited
HD-domain/PDEase-like0.3854Inherited
FKBP-like0.3854Inherited
Class II aaRS and biotin synthetases0.3948Inherited
DHS-like NAD/FAD-binding domain0.4286Inherited
Myosin rod fragments0.4286Inherited
PRTase-like0.4286Inherited
Hect, E3 ligase catalytic domain0.4286Inherited
Galactose-binding domain-like0.4472Inherited
SH2 domain0.4474Inherited
WW domain0.46Inherited
Sm-like ribonucleoproteins0.46Inherited
Cystine-knot cytokines0.46Inherited
Voltage-gated potassium channels0.4708Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.4771Inherited
Calpain large subunit, middle domain (domain III)0.4771Inherited
Riboflavin synthase domain-like0.4771Inherited
UBC-like0.494Inherited
SAM/Pointed domain0.4959Inherited
Seven-hairpin glycosidases0.5315Inherited
Multidrug resistance efflux transporter EmrE0.5324Inherited
PLP-dependent transferases0.5395Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.5508Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.5799Inherited
KA1-like0.5872Inherited
Di-copper centre-containing domain0.5872Inherited
HIT/MYND zinc finger-like0.6069Inherited
GST C-terminal domain-like0.6312Inherited
Frizzled cysteine-rich domain0.6531Inherited
4Fe-4S ferredoxins0.6531Inherited
S15/NS1 RNA-binding domain0.6531Inherited
alpha/beta-Hydrolases0.6676Inherited
Fibronectin type III0.7057Inherited
ADC-like0.7257Inherited
MIT domain0.7257Inherited
Clavaminate synthase-like0.7683Inherited
PapD-like0.7791Inherited
NAD kinase/diacylglycerol kinase-like0.7811Inherited
CoA-dependent acyltransferases0.7867Inherited
Cyclophilin-like0.7867Inherited
EF-hand0.8151Inherited
SNF-like0.8177Inherited
Leucine zipper domain0.8211Inherited
GTPase activation domain, GAP0.8271Inherited
Eukaryotic type KH-domain (KH-domain type I)0.8271Inherited
Thioredoxin-like0.8372Inherited
Ubiquitin-like0.8592Inherited
Immunoglobulin0.8687Inherited
p53-like transcription factors0.8728Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.8786Inherited
Nucleic acid-binding proteins0.9007Inherited
Ribonuclease PH domain 2-like0.9091Inherited
FYVE/PHD zinc finger0.9179Inherited
HAD-like0.9264Inherited
MFS general substrate transporter0.931Inherited
Saposin0.9311Inherited
FAD/NAD(P)-binding domain0.9499Inherited
Periplasmic binding protein-like I0.9499Inherited
Nucleotide cyclase0.9614Inherited
PAZ domain0.9696Inherited
Ribosomal protein S5 domain 2-like0.97Inherited
SET domain0.9754Inherited
Ligand-binding domain in the NO signalling and Golgi transport0.9843Inherited
Ribonuclease H-like0.9927Inherited
Acyl-CoA dehydrogenase NM domain-like0.9988Inherited
Nucleotidylyl transferase0.9988Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.9988Inherited
Bet v1-like1Inherited
DNA/RNA polymerases1Inherited
Insulin-like1Inherited
B-box zinc-binding domain1Inherited
Snake toxin-like1Inherited
Translation proteins SH3-like domain1Inherited
RING/U-box1Inherited
Family A G protein-coupled receptor-like1Inherited
UBA-like1Inherited
Nuclear receptor ligand-binding domain1Inherited
dsRNA-binding domain-like1Inherited
F-box domain1Inherited
E set domains1Inherited
BRCT domain1Inherited
beta-beta-alpha zinc fingers1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
56112,82615
  • 56112 - Protein kinase-like (PK-like)
  • 82615 - Polo-box domain
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    50156,50044
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 0Direct
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0Direct
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0Direct
    48179,48179
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    56176,55103
  • 56176 - FAD-binding/transporter-associated domain-like
  • 55103 - FAD-linked oxidases, C-terminal domain
  • 0Direct
    51905,56425
  • 51905 - FAD/NAD(P)-binding domain
  • 56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
  • 0Direct
    161093,161093
  • 161093 - MgtE membrane domain-like
  • 161093 - MgtE membrane domain-like
  • 0Direct
    52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0Direct
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    141739,141739
  • 141739 - MFPT repeat-like
  • 141739 - MFPT repeat-like
  • 0Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0Direct
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0Direct
    51735,56327
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 56327 - LDH C-terminal domain-like
  • 0Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0Direct
    64356,49447
  • 64356 - SNARE-like
  • 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor
  • 0Direct
    46938,52087
  • 46938 - CRAL/TRIO N-terminal domain
  • 52087 - CRAL/TRIO domain
  • 0Direct
    53738,55957
  • 53738 - Phosphoglucomutase, first 3 domains
  • 55957 - Phosphoglucomutase, C-terminal domain
  • 0Direct
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    56112,48371
  • 56112 - Protein kinase-like (PK-like)
  • 48371 - ARM repeat
  • 0Direct
    52540,81271
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 81271 - TGS-like
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0Direct
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    57889,50729
  • 57889 - Cysteine-rich domain
  • 50729 - PH domain-like
  • 0Direct
    57903,82199
  • 57903 - FYVE/PHD zinc finger
  • 82199 - SET domain
  • 0Direct
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0Direct
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0Direct
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    47741,56176
  • 47741 - CO dehydrogenase ISP C-domain like
  • 56176 - FAD-binding/transporter-associated domain-like
  • 0Direct
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0Direct
    52743,49785
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0Direct
    54211,55060
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55060 - GHMP Kinase, C-terminal domain
  • 0Direct
    49742,49742
  • 49742 - PHM/PNGase F
  • 49742 - PHM/PNGase F
  • 0Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0Direct
    52518,52922
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 0Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    47576,47576
  • 47576 - Calponin-homology domain, CH-domain
  • 47576 - Calponin-homology domain, CH-domain
  • 0Direct
    82615,82615
  • 82615 - Polo-box domain
  • 82615 - Polo-box domain
  • 0Direct
    55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0Direct
    53901,53901
  • 53901 - Thiolase-like
  • 53901 - Thiolase-like
  • 0Direct
    57362,57362
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 0Direct
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0Direct
    56059,52210
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52210 - Succinyl-CoA synthetase domains
  • 0Direct
    68923,53795
  • 68923 - PEP carboxykinase N-terminal domain
  • 53795 - PEP carboxykinase-like
  • 0Direct
    52047,52047
  • 52047 - RNI-like
  • 52047 - RNI-like
  • 0Direct
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    57196,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    52540,46785
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    81301,81631
  • 81301 - Nucleotidyltransferase
  • 81631 - PAP/OAS1 substrate-binding domain
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0Direct
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0Direct
    57863,48403
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0Direct
    51971,54373
  • 51971 - Nucleotide-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 0Direct
    47769,47769
  • 47769 - SAM/Pointed domain
  • 47769 - SAM/Pointed domain
  • 0Direct
    81383,52047
  • 81383 - F-box domain
  • 52047 - RNI-like
  • 0Direct
    81698,81698
  • 81698 - FF domain
  • 81698 - FF domain
  • 0Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0Direct
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    51338,51556
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 0Direct
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0Direct
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0Direct
    57414,57414
  • 57414 - Hairpin loop containing domain-like
  • 57414 - Hairpin loop containing domain-like
  • 0Direct
    55729,55729
  • 55729 - Acyl-CoA N-acyltransferases (Nat)
  • 55729 - Acyl-CoA N-acyltransferases (Nat)
  • 0Direct
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0Direct
    51445,54556
  • 51445 - (Trans)glycosidases
  • 54556 - Chitinase insertion domain
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    88713,88688
  • 88713 - Glycoside hydrolase/deacetylase
  • 88688 - Families 57/38 glycoside transferase middle domain
  • 0Direct
    100950,100950
  • 100950 - NagB/RpiA/CoA transferase-like
  • 100950 - NagB/RpiA/CoA transferase-like
  • 0Direct
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    48425,50729
  • 48425 - Sec7 domain
  • 50729 - PH domain-like
  • 0Direct
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0Direct
    46785,46785
  • 46785 - "Winged helix" DNA-binding domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    57889,48350
  • 57889 - Cysteine-rich domain
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    55326,56042
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 0Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    47203,47203
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    53738,53738
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 0Direct
    53187,49464
  • 53187 - Zn-dependent exopeptidases
  • 49464 - Carboxypeptidase regulatory domain-like
  • 0Direct
    51735,55347
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 0Direct
    81383,50978
  • 81383 - F-box domain
  • 50978 - WD40 repeat-like
  • 0Direct
    52518,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    54897,53187
  • 54897 - Protease propeptides/inhibitors
  • 53187 - Zn-dependent exopeptidases
  • 0Direct
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    47587,56399
  • 47587 - Domain of poly(ADP-ribose) polymerase
  • 56399 - ADP-ribosylation
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    144232,82199
  • 144232 - HIT/MYND zinc finger-like
  • 82199 - SET domain
  • 0Direct
    50129,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0Direct
    48403,52151
  • 48403 - Ankyrin repeat
  • 52151 - FabD/lysophospholipase-like
  • 0Direct
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    48464,89009
  • 48464 - ENTH/VHS domain
  • 89009 - GAT-like domain
  • 0Direct
    74650,51445
  • 74650 - Galactose mutarotase-like
  • 51445 - (Trans)glycosidases
  • 0Direct
    53187,55031
  • 53187 - Zn-dependent exopeptidases
  • 55031 - Bacterial exopeptidase dimerisation domain
  • 0Direct
    47473,103506
  • 47473 - EF-hand
  • 103506 - Mitochondrial carrier
  • 0Direct
    54236,54236
  • 54236 - Ubiquitin-like
  • 54236 - Ubiquitin-like
  • 0Direct
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0Direct
    57756,57756
  • 57756 - Retrovirus zinc finger-like domains
  • 57756 - Retrovirus zinc finger-like domains
  • 0Direct
    56601,48403
  • 56601 - beta-lactamase/transpeptidase-like
  • 48403 - Ankyrin repeat
  • 0Direct
    54665,56003
  • 54665 - CO dehydrogenase molybdoprotein N-domain-like
  • 56003 - Molybdenum cofactor-binding domain
  • 0Direct
    54897,52743
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 0Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0Direct
    52283,51735
  • 52283 - Formate/glycerate dehydrogenase catalytic domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    161111,160240
  • 161111 - Cation efflux protein transmembrane domain-like
  • 160240 - Cation efflux protein cytoplasmic domain-like
  • 0Direct
    141673,50800
  • 141673 - MOSC N-terminal domain-like
  • 50800 - PK beta-barrel domain-like
  • 0Direct
    47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    57938,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0Direct
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0Direct
    52540,140990
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 140990 - FtsH protease domain-like
  • 0Direct
    49348,55711
  • 49348 - Clathrin adaptor appendage domain
  • 55711 - Subdomain of clathrin and coatomer appendage domain
  • 0Direct
    54292,47741
  • 54292 - 2Fe-2S ferredoxin-like
  • 47741 - CO dehydrogenase ISP C-domain like
  • 0Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    51556,51338
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0Direct
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    50044,52540
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    55920,46785
  • 55920 - Creatinase/aminopeptidase
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    81324,81327
  • 81324 - Voltage-gated potassium channels
  • 81327 - Small-conductance potassium channel
  • 0Direct
    50978,50998
  • 50978 - WD40 repeat-like
  • 50998 - Quinoprotein alcohol dehydrogenase-like
  • 0Direct
    57850,117839
  • 57850 - RING/U-box
  • 117839 - WWE domain
  • 0Direct
    56672,100879
  • 56672 - DNA/RNA polymerases
  • 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain
  • 0Direct
    55394,55394
  • 55394 - Bactericidal permeability-increasing protein, BPI
  • 55394 - Bactericidal permeability-increasing protein, BPI
  • 0Direct
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    57625,57625
  • 57625 - Invertebrate chitin-binding proteins
  • 57625 - Invertebrate chitin-binding proteins
  • 0Direct
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.01469Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.06453Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.08771Inherited
    56112,55073
  • 56112 - Protein kinase-like (PK-like)
  • 55073 - Nucleotide cyclase
  • 0.1107Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.1107Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.1123Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.1758Inherited
    56436,49854
  • 56436 - C-type lectin-like
  • 49854 - Spermadhesin, CUB domain
  • 0.2024Inherited
    51735,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0.2208Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.2208Inherited
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.2769Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.2769Inherited
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.3095Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.3114Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.351Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.4265Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 0.4651Inherited
    101690,53098
  • 101690 - PAZ domain
  • 53098 - Ribonuclease H-like
  • 0.5315Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.5315Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.5872Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.6531Inherited
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0.6531Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.655Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.7257Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.7867Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.8133Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.8173Inherited
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0.9091Inherited
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.9106Inherited
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0.9382Inherited
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0.9382Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.9988Inherited
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 1Inherited
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 1Inherited
    53300,56436
  • 53300 - vWA-like
  • 56436 - C-type lectin-like
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    56645,47203,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    46938,52087,101576
  • 46938 - CRAL/TRIO N-terminal domain
  • 52087 - CRAL/TRIO domain
  • 101576 - Supernatant protein factor (SPF), C-terminal domain
  • 0Direct
    54292,47741,56176
  • 54292 - 2Fe-2S ferredoxin-like
  • 47741 - CO dehydrogenase ISP C-domain like
  • 56176 - FAD-binding/transporter-associated domain-like
  • 0Direct
    57938,49493,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0Direct
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    50249,50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    54928,54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    56436,49854,49854
  • 56436 - C-type lectin-like
  • 49854 - Spermadhesin, CUB domain
  • 49854 - Spermadhesin, CUB domain
  • 0Direct
    50156,50044,52540
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    48371,48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    54897,52743,49785
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0Direct
    53738,53738,55957
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 55957 - Phosphoglucomutase, C-terminal domain
  • 0Direct
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0Direct
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0Direct
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0Direct
    55973,55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0Direct
    56112,82615,82615
  • 56112 - Protein kinase-like (PK-like)
  • 82615 - Polo-box domain
  • 82615 - Polo-box domain
  • 0Direct
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53738,53738,53738
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    57362,57362,57362
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 0Direct
    82895,82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    57414,57414,57414
  • 57414 - Hairpin loop containing domain-like
  • 57414 - Hairpin loop containing domain-like
  • 57414 - Hairpin loop containing domain-like
  • 0Direct
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    57625,57625,57625
  • 57625 - Invertebrate chitin-binding proteins
  • 57625 - Invertebrate chitin-binding proteins
  • 57625 - Invertebrate chitin-binding proteins
  • 0Direct
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0Direct
    50044,50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0Direct
    57567,57567,57567
  • 57567 - Serine protease inhibitors
  • 57567 - Serine protease inhibitors
  • 57567 - Serine protease inhibitors
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    51735,48179,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    74650,51445,51011
  • 74650 - Galactose mutarotase-like
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0Direct
    48452,48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0Direct
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    48726,49265,48726
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.1245Inherited
    56436,56436,49854
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 49854 - Spermadhesin, CUB domain
  • 0.3378Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.346Inherited
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.346Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.4286Inherited
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.8238Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9311Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.9843Inherited


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