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Worm Phenotype (WP): organism homeostasis metabolism variant

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Variant [WBPhenotype:0000886] <5>
+ + 2:   physiology variant [WBPhenotype:0000519] <6>(495|573) (496|248|69)
+ 1:   organism physiology variant [WBPhenotype:0000576] <10>(360|427) (361|200|61)
0:   organism homeostasis metabolism variant [WBPhenotype:0000577] <17>(349|415) (351|198|60)
- 1:   organism metabolism processing variant [WBPhenotype:0000027] <25>(171|180) (178|83|25)
- 1:   organism environmental stimulus response variant [WBPhenotype:0000738] <17>(115|108) (118|52|15)
- 1:   RNAi response variant [WBPhenotype:0000743] <11>(8|10) (8|4|0)
- 1:   metal homeostasis variant [WBPhenotype:0002029] <6>(0|0) (0|0|0)
- 1:   growth variant [WBPhenotype:0000030] <4>(203|268) (204|127|42)
- 1:   maintenance of gene silencing variant [WBPhenotype:0002063] <4>(11|8) (11|2|0)
- 1:   hydrogen peroxide homeostasis variant [WBPhenotype:0002003] <2>(1|1) (1|0|0)
- 1:   osmotic integrity variant [WBPhenotype:0000041] <2>(6|8) (7|2|0)
- 1:   reactive oxygen species homeostasis variant [WBPhenotype:0002182] <2>(1|1) (1|0|0)
- 1:   ascaroside biosynthesis variant [WBPhenotype:0002051] <1>(2|2) (2|2|1)
- 1:   spontaneous mutation rate increased [WBPhenotype:0000228] <1>(6|5) (6|3|1)
- 1:   cation homeostasis variant [WBPhenotype:0002073](0|0) (0|0|0)
- 1:   hypersensitive to laser ablation [WBPhenotype:0001998](0|0) (0|0|0)
- 1:   hypersensitivity to mutagen [WBPhenotype:0001781](0|0) (0|0|0)
- 1:   protein signaling variant [WBPhenotype:0001207](0|0) (0|0|0)
- 1:   resistant to mutagens [WBPhenotype:0001788](0|0) (0|0|0)
- 1:   starved [WBPhenotype:0000547](0|0) (0|0|0)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)0Direct
PAP/OAS1 substrate-binding domain0Direct
alpha/beta knot0Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0Direct
Integrin domains0Direct
Cation efflux protein cytoplasmic domain-like0Direct
PYP-like sensor domain (PAS domain)0Direct
LysM domain0Direct
PABC (PABP) domain0Direct
Skp1 dimerisation domain-like0Direct
Troponin coil-coiled subunits0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
Profilin (actin-binding protein)0Direct
SWIB/MDM2 domain0Direct
Cullin repeat-like0Direct
PurM N-terminal domain-like0Direct
TK C-terminal domain-like0Direct
SPOC domain-like0Direct
Tricorn protease domain 20Direct
Phoshotransferase/anion transport protein0Direct
Intermediate filament protein, coiled coil region0Direct
Integrin alpha N-terminal domain0Direct
TGS-like0Direct
VPS9 domain0Direct
ENTH/VHS domain0Direct
S-adenosylmethionine synthetase0Direct
Bacterial exopeptidase dimerisation domain0Direct
Thiolase-like0Direct
FF domain0Direct
Chromo domain-like0Direct
Restriction endonuclease-like0Direct
CAD & PB1 domains0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
Pentein0Direct
WGR domain-like0Direct
DEATH domain0Direct
CO dehydrogenase ISP C-domain like0Direct
SAICAR synthase-like0Direct
BEACH domain0Direct
CBD9-like0Direct
CRAL/TRIO N-terminal domain0Direct
Composite domain of metallo-dependent hydrolases0Direct
ArfGap/RecO-like zinc finger0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
F1F0 ATP synthase subunit C0Direct
HSP90 C-terminal domain0Direct
Cystatin/monellin0Direct
PEBP-like0Direct
ADP-ribosylation0Direct
Clathrin adaptor appendage domain0Direct
WWE domain0Direct
FtsH protease domain-like0Direct
Heme-dependent catalase-like0Direct
Terpenoid synthases0Direct
Nop domain0Direct
Rap/Ran-GAP0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
Tubulin nucleotide-binding domain-like0Direct
Hect, E3 ligase catalytic domain0Direct
SMAD MH1 domain0Direct
Domain of poly(ADP-ribose) polymerase0Direct
Ribulose-phoshate binding barrel0Direct
Phosphoglucomutase, C-terminal domain0Direct
PreATP-grasp domain0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
Cullin homology domain0Direct
Transducin (alpha subunit), insertion domain0Direct
PGBD-like0Direct
L-aspartase-like0Direct
Spectrin repeat0Direct
Rudiment single hybrid motif0Direct
ALDH-like0Direct
GroEL-intermediate domain like0Direct
GINS helical bundle-like0Direct
Ribosomal protein S100Direct
Tubulin C-terminal domain-like0Direct
Creatinase/prolidase N-terminal domain0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Periplasmic binding protein-like II0Direct
PK beta-barrel domain-like0Direct
Phosphoglucomutase, first 3 domains0Direct
GAS2 domain-like0Direct
Zn-finger domain of Sec23/240Direct
Hedgehog/intein (Hint) domain0Direct
cAMP-binding domain-like0Direct
PurM C-terminal domain-like0Direct
ClpP/crotonase0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
MgtE membrane domain-like0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
Ran binding protein zinc finger-like0Direct
MFPT repeat-like0Direct
Acid phosphatase/Vanadium-dependent haloperoxidase0Direct
Tubby C-terminal domain-like0Direct
PLC-like phosphodiesterases0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
FAD-dependent thiol oxidase0Direct
Glycolipid transfer protein, GLTP0Direct
Single hybrid motif0Direct
Citrate synthase0Direct
GHMP Kinase, C-terminal domain0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
Carbon-nitrogen hydrolase0Direct
Carbohydrate phosphatase0Direct
Nucleoporin domain0Direct
Formate/glycerate dehydrogenase catalytic domain-like0Direct
L30e-like0Direct
Putative DNA-binding domain0Direct
PEP carboxykinase-like0Direct
Carboxypeptidase regulatory domain-like0Direct
Annexin0Direct
Hormone receptor domain0Direct
Terpenoid cyclases/Protein prenyltransferases0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Cdc48 domain 2-like0Direct
3-carboxy-cis,cis-mucoante lactonizing enzyme0Direct
Radical SAM enzymes0Direct
Subtilisin-like0Direct
ISP domain0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
HSP40/DnaJ peptide-binding domain0Direct
Cadherin-like0Direct
Oxysterol-binding protein-like0Direct
MIR domain0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
Glutathione synthetase ATP-binding domain-like0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
t-snare proteins0Direct
AN1-like Zinc finger0Direct
Fibrinogen C-terminal domain-like0Direct
Ribosomal proteins S24e, L23 and L15e0Direct
lambda repressor-like DNA-binding domains0Direct
Translational machinery components0Direct
Chitinase insertion domain0Direct
Transducin (heterotrimeric G protein), gamma chain0Direct
Calcium-dependent phosphotriesterase0Direct
Protease propeptides/inhibitors0Direct
LDH C-terminal domain-like0Direct
Actin-like ATPase domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Aldolase0Direct
Small-conductance potassium channel0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
Blood coagulation inhibitor (disintegrin)0Direct
YWTD domain0Direct
Surp module (SWAP domain)0Direct
PAP/Archaeal CCA-adding enzyme, C-terminal domain0Direct
DNA repair protein MutS, domain III0Direct
Nucleotidyltransferase0Direct
RBP11-like subunits of RNA polymerase0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
GroEL equatorial domain-like0Direct
eIF4e-like0Direct
GroES-like0Direct
ValRS/IleRS/LeuRS editing domain0Direct
SIS domain0Direct
HMG-box0Direct
Zn-binding ribosomal proteins0Direct
Galactose mutarotase-like0Direct
Phosphoenolpyruvate/pyruvate domain0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Diaminopimelate epimerase-like0Direct
Smc hinge domain0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
dsRNA-binding domain-like0Direct
Cu,Zn superoxide dismutase-like0Direct
R3H domain0Direct
Sec1/munc18-like (SM) proteins0Direct
GYF domain0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Ribokinase-like0Direct
Ferritin-like0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Hypothetical protein c14orf129, hspc2100Direct
GAT-like domain0Direct
Clc chloride channel0Direct
Mitochondrial carrier0Direct
PHM/PNGase F0Direct
Molybdenum cofactor-binding domain0Direct
MOSC N-terminal domain-like0Direct
HCP-like0Direct
Band 7/SPFH domain0Direct
Chaperone J-domain0Direct
14-3-3 protein0Direct
Heme-dependent peroxidases0Direct
PLP-binding barrel0Direct
2Fe-2S ferredoxin-like0Direct
Tim10-like0Direct
ARID-like0Direct
Families 57/38 glycoside transferase middle domain0Direct
Class I glutamine amidotransferase-like0Direct
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase0Direct
HSP20-like chaperones0Direct
Helical domain of Sec23/240Direct
Invertebrate chitin-binding proteins0Direct
Ribosomal L27 protein-like0Direct
JAB1/MPN domain0Direct
PEP carboxykinase N-terminal domain0Direct
beta-lactamase/transpeptidase-like0Direct
ThrRS/AlaRS common domain0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Elafin-like0Direct
Sec63 N-terminal domain-like0Direct
Ribosomal protein L10-like0Direct
LEM domain0Direct
alpha-catenin/vinculin-like0Direct
Activating enzymes of the ubiquitin-like proteins0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Proton glutamate symport protein0Direct
Alpha-L RNA-binding motif0Direct
Ribosomal protein L10Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0Direct
SMAD/FHA domain0Direct
Nucleoside diphosphate kinase, NDK0Direct
Sec7 domain0Direct
Polo-box domain0Direct
YbiA-like0Direct
Pepsin inhibitor-30Direct
PIN domain-like0Direct
Doublecortin (DC)0Direct
Class II aaRS ABD-related0Direct
Galactose oxidase, central domain0Direct
Complement control module/SCR domain0Direct
GroEL apical domain-like0Direct
SAND domain-like0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Cytochrome c0Direct
Succinyl-CoA synthetase domains0Direct
Thyroglobulin type-1 domain0Direct
Lamin A/C globular tail domain0Direct
Outer arm dynein light chain 10Direct
Second domain of FERM0Direct
Arginase/deacetylase0Direct
PH domain-like0.000001534Direct
Histone-fold0.0000718Direct
PDZ domain-like0.008807Inherited
TPR-like0.01176Inherited
ARM repeat0.01927Inherited
"Winged helix" DNA-binding domain0.01995Inherited
SH2 domain0.03324Inherited
WD40 repeat-like0.03764Inherited
Acetyl-CoA synthetase-like0.05829Inherited
Homeodomain-like0.05944Inherited
EGF/Laminin0.05996Inherited
Cyclin-like0.06511Inherited
CCCH zinc finger0.07271Inherited
Ankyrin repeat0.07499Inherited
Galactose-binding domain-like0.08928Inherited
Translation proteins0.09049Inherited
RNI-like0.1067Inherited
ABC transporter transmembrane region0.1069Inherited
HLH, helix-loop-helix DNA-binding domain0.1069Inherited
Calcium ATPase, transmembrane domain M0.1254Inherited
SH3-domain0.1343Inherited
Regulator of G-protein signaling, RGS0.1395Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.1395Inherited
Calcium ATPase, transduction domain A0.1554Inherited
Class II aaRS and biotin synthetases0.1554Inherited
Quinoprotein alcohol dehydrogenase-like0.1729Inherited
Multidrug efflux transporter AcrB transmembrane domain0.1801Inherited
(Trans)glycosidases0.1879Inherited
Cytochrome P4500.1879Inherited
P-loop containing nucleoside triphosphate hydrolases0.1892Inherited
WW domain0.1922Inherited
DBL homology domain (DH-domain)0.1922Inherited
Cysteine proteinases0.2305Inherited
BRCT domain0.2308Inherited
Multidrug resistance efflux transporter EmrE0.2371Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.2581Inherited
POZ domain0.2627Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.2632Inherited
Bromodomain0.2632Inherited
SNARE-like0.2911Inherited
SAM/Pointed domain0.2927Inherited
Lipocalins0.2927Inherited
RNA-binding domain, RBD0.2971Inherited
Cation efflux protein transmembrane domain-like0.357Inherited
FYVE/PHD zinc finger0.3663Inherited
Acid proteases0.3675Inherited
Cysteine-rich domain0.3819Inherited
Nicotinic receptor ligand binding domain-like0.4047Inherited
FKBP-like0.437Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.4421Inherited
HAD-like0.4437Inherited
PRTase-like0.4814Inherited
DHS-like NAD/FAD-binding domain0.4814Inherited
Myosin rod fragments0.4814Inherited
Cystine-knot cytokines0.5226Inherited
Sm-like ribonucleoproteins0.5226Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.5297Inherited
Riboflavin synthase domain-like0.5297Inherited
Calpain large subunit, middle domain (domain III)0.5297Inherited
Growth factor receptor domain0.5677Inherited
Voltage-gated potassium channels0.5718Inherited
UBC-like0.572Inherited
Seven-hairpin glycosidases0.5849Inherited
alpha/beta-Hydrolases0.6284Inherited
Osmotin, thaumatin-like protein0.6405Inherited
KA1-like0.6405Inherited
Lipovitellin-phosvitin complex, superhelical domain0.6405Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.6405Inherited
GTPase activation domain, GAP0.701Inherited
Frizzled cysteine-rich domain0.7054Inherited
S15/NS1 RNA-binding domain0.7054Inherited
GST C-terminal domain-like0.7253Inherited
PAZ domain0.7277Inherited
MIT domain0.7756Inherited
ADC-like0.7756Inherited
Fibronectin type III0.7832Inherited
PapD-like0.7844Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.7863Inherited
Protein kinase-like (PK-like)0.8365Inherited
Ribonuclease H-like0.8775Inherited
Ubiquitin-like0.8775Inherited
Leucine zipper domain0.8805Inherited
Nucleic acid-binding proteins0.92Inherited
p53-like transcription factors0.9289Inherited
MFS general substrate transporter0.9361Inherited
Immunoglobulin0.9377Inherited
Ribonuclease PH domain 2-like0.9524Inherited
EF-hand0.9535Inherited
FAD/NAD(P)-binding domain0.9712Inherited
beta-beta-alpha zinc fingers0.9728Inherited
Periplasmic binding protein-like I0.9739Inherited
Thioredoxin-like0.9825Inherited
Nucleotide cyclase0.9857Inherited
Ribosomal protein S5 domain 2-like0.9889Inherited
Eukaryotic type KH-domain (KH-domain type I)0.9913Inherited
SET domain0.9981Inherited
Acyl-CoA dehydrogenase C-terminal domain-like1Inherited
Saposin1Inherited
CoA-dependent acyltransferases1Inherited
Acyl-CoA dehydrogenase NM domain-like1Inherited
F-box domain1Inherited
Nuclear receptor ligand-binding domain1Inherited
Translation proteins SH3-like domain1Inherited
RING/U-box1Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase1Inherited
DNA/RNA polymerases1Inherited
Clavaminate synthase-like1Inherited
B-box zinc-binding domain1Inherited
Family A G protein-coupled receptor-like1Inherited
E set domains1Inherited
Calponin-homology domain, CH-domain1Inherited
Cyclophilin-like1Inherited
Ligand-binding domain in the NO signalling and Golgi transport1Inherited
UBA-like1Inherited
Nucleotidylyl transferase1Inherited
Bet v1-like1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
UBA domain0Direct
CO dehydrogenase flavoprotein N-terminal domain-like0Direct
alpha-mannosidase, C-terminal domain0Direct
FHA domain0Direct
Carboxypeptidase regulatory domain0Direct
Ribosomal protein S100Direct
Formate/glycerate dehydrogenases, NAD-domain0Direct
Hydantoinase (dihydropyrimidinase), catalytic domain0Direct
FF domain0Direct
AN1-like Zinc finger0Direct
Quinoprotein alcohol dehydrogenase-like0Direct
MOSC N-terminal domain-like0Direct
Internalin LRR domain0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
Thiolase-related0Direct
Proteasome subunits0Direct
Band 7/SPFH domain0Direct
Tubulin, GTPase domain0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Zn-finger domain of Sec23/240Direct
Actin/HSP700Direct
Ngr ectodomain-like0Direct
Poly(A) polymerase, PAP, middle domain0Direct
Anticodon-binding domain0Direct
Intermediate filament protein, coiled coil region0Direct
Class I glutamine amidotransferases (GAT)0Direct
DEP domain0Direct
Heme-dependent catalases0Direct
L-aminoacid/polyamine oxidase0Direct
RNA editing terminal uridyl transferase 2, RET2, domain 20Direct
Phosphoribosyltransferases (PRTases)0Direct
D-aminoacid oxidase-like0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
HSP40/DnaJ peptide-binding domain0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
Cytoplasmic domain of inward rectifier potassium channel0Direct
Rap/Ran-GAP0Direct
EGF-type module0Direct
Transducin (heterotrimeric G protein), gamma chain0Direct
Choline kinase0Direct
HD domain0Direct
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)0Direct
28-residue LRR0Direct
Sec7 domain0Direct
Cullin repeat0Direct
Fibrinogen C-terminal domain-like0Direct
Regulator of chromosome condensation RCC10Direct
SAND domain0Direct
Sec63 C-terminal domain-like0Direct
LysM domain0Direct
Profilin (actin-binding protein)0Direct
alpha-mannosidase0Direct
Class I aldolase0Direct
RNA-polymerase beta-prime0Direct
PLC-like (P variant)0Direct
U-box0Direct
Crotonase-like0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
Poly(ADP-ribose) polymerase, C-terminal domain0Direct
Tubulin, C-terminal domain0Direct
Sec1/munc18-like (SM) proteins0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Smc hinge domain0Direct
Group II chaperonin (CCT, TRIC), ATPase domain0Direct
Cu,Zn superoxide dismutase-like0Direct
Branched-chain alpha-keto acid dehydrogenase PP module0Direct
Citrate synthase0Direct
Lactate & malate dehydrogenases, C-terminal domain0Direct
PurM N-terminal domain-like0Direct
AlkB-like0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
VHS domain0Direct
Sec63 N-terminal domain0Direct
Epoxide hydrolase0Direct
Chitinase insertion domain0Direct
Second domain of FERM0Direct
Fatty acid binding protein-like0Direct
DEATH domain, DD0Direct
Lesion bypass DNA polymerase (Y-family), catalytic domain0Direct
DPP6 N-terminal domain-like0Direct
Reprolysin-like0Direct
Inositol polyphosphate kinase (IPK)0Direct
FtsH protease domain-like0Direct
1,3-glucuronyltransferase0Direct
First domain of FERM0Direct
Hydantoinase (dihydropyrimidinase)0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0Direct
PaaI/YdiI-like0Direct
Erythroid transcription factor GATA-10Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0Direct
Cell cycle control phosphatase, catalytic domain0Direct
Amylase, catalytic domain0Direct
Pyk2-associated protein beta ARF-GAP domain0Direct
t-snare proteins0Direct
Glycogenin0Direct
Molybdenum cofactor-binding domain0Direct
Phosphotyrosine-binding domain (PTB)0Direct
Alcohol dehydrogenase-like, C-terminal domain0Direct
SMAD domain0Direct
Branched-chain alpha-keto acid dehydrogenase Pyr module0Direct
ATP-dependent protease Lon (La), catalytic domain0Direct
Myotubularin-like phosphatases0Direct
HEAT repeat0Direct
Polo-box duplicated region0Direct
Clathrin adaptor core protein0Direct
La domain0Direct
CoA-binding domain0Direct
Cullin homology domain0Direct
BAR domain0Direct
Calpain large subunit, catalytic domain (domain II)0Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
Hormone receptor domain0Direct
Transducin (alpha subunit), insertion domain0Direct
Cadherin0Direct
MIR domain0Direct
LEM domain0Direct
HAT/Suf repeat0Direct
S-adenosylmethionine synthetase0Direct
YihX-like0Direct
Hect, E3 ligase catalytic domain0Direct
PDZ domain0Direct
Arfaptin, Rac-binding fragment0Direct
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta0Direct
Ubiquitin activating enzymes (UBA)0Direct
Biotin dependent carboxylase carboxyltransferase domain0Direct
Glycolipid transfer protein, GLTP0Direct
Third domain of FERM0Direct
Type II chitinase0Direct
Hsp90 middle domain0Direct
SWIB/MDM2 domain0Direct
L30e/L7ae ribosomal proteins0Direct
Cyclin0Direct
RecA protein-like (ATPase-domain)0Direct
SCF ubiquitin ligase complex WHB domain0Direct
Nop domain0Direct
MutT-like0Direct
PEP carboxykinase C-terminal domain0Direct
Adenosine/AMP deaminase0Direct
Biotinyl/lipoyl-carrier proteins and domains0Direct
Aminoacid dehydrogenase-like, C-terminal domain0Direct
PABC (PABP) domain0Direct
CO dehydrogenase ISP C-domain like0Direct
Single strand DNA-binding domain, SSB0Direct
RNA-polymerase beta0Direct
Proton glutamate symport protein0Direct
a tRNA synthase domain0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
p120GAP domain-like0Direct
Ribokinase-like0Direct
HSP90 C-terminal domain0Direct
Surp module (SWAP domain)0Direct
Pancreatic carboxypeptidases0Direct
Spectrin repeat0Direct
AMPK-beta glycogen binding domain-like0Direct
Protein prenyltransferases0Direct
Ribosomal protein L18 and S110Direct
Mitochondrial carrier0Direct
DPP6 catalytic domain-like0Direct
GYF domain0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
Group II chaperonin (CCT, TRIC), apical domain0Direct
Lamin A/C globular tail domain0Direct
acyl-CoA oxidase C-terminal domains0Direct
Acyl-CoA thioesterase0Direct
PhzC/PhzF-like0Direct
YicI catalytic domain-like0Direct
WGR domain0Direct
Ribosomal protein L10Direct
Calcium ATPase, transmembrane domain M0Direct
SMAD MH1 domain0Direct
Armadillo repeat0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
Class II glutamine amidotransferases0Direct
beta 1,4 galactosyltransferase (b4GalT1)0Direct
Doublecortin (DC)0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Ran binding protein zinc finger-like0Direct
Pleckstrin-homology domain (PH domain)0Direct
FAD-dependent thiol oxidase0Direct
PurM C-terminal domain-like0Direct
Peptidylglycine alpha-hydroxylating monooxygenase, PHM0Direct
LDH N-terminal domain-like0Direct
Helical domain of Sec23/240Direct
Elafin-like0Direct
Blood coagulation inhibitor (disintegrin)0Direct
COMT-like0Direct
BC ATP-binding domain-like0Direct
Phosphatidylethanolamine binding protein0Direct
Hedgehog C-terminal (Hog) autoprocessing domain0Direct
acyl-CoA oxidase N-terminal domains0Direct
Chaperone J-domain0Direct
Hypothetical protein c14orf129, hspc2100Direct
Acylamino-acid-releasing enzyme, C-terminal donain0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
D-aminoacid oxidase, N-terminal domain0Direct
2Fe-2S ferredoxin domains from multidomain proteins0Direct
HSP200Direct
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain0Direct
Bacterial exopeptidase dimerisation domain0Direct
Subtilases0Direct
Translational machinery components0Direct
Methionine aminopeptidase, insert domain0Direct
Skp1 dimerisation domain-like0Direct
POU-specific domain0Direct
CRAL/TRIO N-terminal domain0Direct
LacY-like proton/sugar symporter0Direct
Anticodon-binding domain of Class II aaRS0Direct
PDI-like0Direct
Laminin G-like module0Direct
IF2B-like0Direct
Chromo domain0Direct
Nucleoside diphosphate kinase, NDK0Direct
Cdc48 domain 2-like0Direct
Bactericidal permeability-increasing protein, BPI0Direct
Pepsin inhibitor-30Direct
Glycerol kinase0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
Reductases0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
Glutaminase0Direct
XPF/Rad1/Mus81 nuclease0Direct
Glycosyl transferases group 10Direct
beta-Lactamase/D-ala carboxypeptidase0Direct
Succinyl-CoA synthetase domains0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Tim10/DDP0Direct
CUT domain0Direct
BEACH domain0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Phosphate binding protein-like0Direct
Inositol monophosphatase/fructose-1,6-bisphosphatase-like0Direct
HMG-box0Direct
Adenain-like0Direct
Cation efflux protein cytoplasmic domain-like0Direct
Acyl-carrier protein (ACP)0Direct
F1F0 ATP synthase subunit C0Direct
Trunk domain of Sec23/240Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
MFPT repeat0Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0Direct
YbiA-like0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Clathrin coat assembly domain0Direct
WWE domain0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
ets domain0Direct
UDP-glucose pyrophosphorylase0Direct
Phosphoglucomutase, first 3 domains0Direct
Gamma-glutamyltranspeptidase-like0Direct
Proprotein convertase P-domain0Direct
Double-stranded RNA-binding domain (dsRBD)0Direct
Cofilin-like0Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
cAMP-binding domain0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
Matrix metalloproteases, catalytic domain0Direct
Mammalian PLC0Direct
BC C-terminal domain-like0Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0Direct
Glycerophosphoryl diester phosphodiesterase0Direct
Small-conductance potassium channel0Direct
GHMP Kinase, N-terminal domain0Direct
Acireductone dioxygenase0Direct
SWIRM domain0Direct
YWTD domain0Direct
Poly(A) polymerase, PAP, C-terminal domain0Direct
HCDH C-domain-like0Direct
Paired domain0Direct
alpha-catenin/vinculin0Direct
Ribonucleotide reductase-like0Direct
Thyroglobulin type-1 domain0Direct
Translation initiation factor eIF4e0Direct
GAS2 domain0Direct
SAM (sterile alpha motif) domain0Direct
PEP carboxykinase N-terminal domain0Direct
Integrin domains0Direct
Pancreatic carboxypeptidase, activation domain0Direct
Regulator of G-protein signaling, RGS0Direct
GAPDH-like0Direct
Histone deacetylase, HDAC0Direct
NTF2-like0Direct
MIF4G domain-like0Direct
5' to 3' exonuclease catalytic domain0Direct
Troponin I0Direct
Oxysterol-binding protein0Direct
Tetraspanin0Direct
14-3-3 protein0Direct
Domain of poly(ADP-ribose) polymerase0Direct
Arylsulfatase0Direct
Sir2 family of transcriptional regulators0Direct
NOL1/NOP2/sun0Direct
Clc chloride channel0Direct
Brix domain0Direct
Annexin0Direct
Ras-binding domain, RBD0Direct
Nucleosome core histones0Direct
ALDH-like0Direct
Arginine methyltransferase0Direct
Hexokinase0Direct
DNA repair protein MutS, domain III0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
RhoGDI-like0Direct
NHL repeat0Direct
Complement control module/SCR domain0Direct
Linker histone H1/H50Direct
alpha-mannosidase, domain 20Direct
PUA domain0Direct
CAT-like0Direct
beta-sandwich domain of Sec23/240Direct
Myeloperoxidase-like0Direct
Poly(A) polymerase, PAP, N-terminal domain0Direct
BC N-terminal domain-like0Direct
ARID domain0Direct
Alcohol dehydrogenase-like, N-terminal domain0Direct
Tandem AAA-ATPase domain0.0003035Direct
G proteins0.02045Inherited
Homeodomain0.03602Inherited
ABC transporter ATPase domain-like0.03679Inherited
WD40-repeat0.04564Inherited
SH2 domain0.05011Inherited
Acetyl-CoA synthetase-like0.07007Inherited
CCCH zinc finger0.08574Inherited
Canonical RBD0.08899Inherited
Tetratricopeptide repeat (TPR)0.113Inherited
Ankyrin repeat0.1253Inherited
HLH, helix-loop-helix DNA-binding domain0.1329Inherited
Calcium ATPase, transduction domain A0.1736Inherited
SH3-domain0.1814Inherited
ABC transporter transmembrane region0.1833Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.2112Inherited
Elongation factors0.2112Inherited
Extended PAW domain0.2112Inherited
DBL homology domain (DH-domain)0.2112Inherited
Pepsin-like0.2112Inherited
WW domain0.2112Inherited
Acetylcholinesterase-like0.212Inherited
Dual specificity phosphatase-like0.2332Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.2569Inherited
Extended AAA-ATPase domain0.2573Inherited
Cytochrome P4500.259Inherited
Multidrug efflux transporter AcrB transmembrane domain0.267Inherited
FYVE, a phosphatidylinositol-3-phosphate binding domain0.2827Inherited
Bromodomain0.2827Inherited
6-phosphogluconate dehydrogenase-like, N-terminal domain0.2827Inherited
FAD/NAD-linked reductases, N-terminal and central domains0.3114Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3256Inherited
Meta-cation ATPase, catalytic domain P0.3431Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP0.3431Inherited
Pumilio repeat0.4143Inherited
GABA-aminotransferase-like0.4143Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.4359Inherited
FKBP immunophilin/proline isomerase0.4554Inherited
Cation efflux protein transmembrane domain-like0.4554Inherited
PHD domain0.4654Inherited
Pyridoxal-dependent decarboxylase0.4985Inherited
Myosin rod fragments0.4985Inherited
Glutathione S-transferase (GST), N-terminal domain0.5021Inherited
Nicotinic receptor ligand binding domain-like0.5272Inherited
I set domains0.5274Inherited
Papain-like0.5374Inherited
Gastric lipase0.5481Inherited
Calpain large subunit, middle domain (domain III)0.5481Inherited
Myb/SANT domain0.5481Inherited
UBC-related0.59Inherited
Class I alpha-1;2-mannosidase, catalytic domain0.598Inherited
Synaptotagmin-like (S variant)0.6299Inherited
BTB/POZ domain0.6318Inherited
Ubiquitin carboxyl-terminal hydrolase, UCH0.6471Inherited
Osmotin, thaumatin-like protein0.656Inherited
Lipovitellin-phosvitin complex, superhelical domain0.656Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.656Inherited
Frizzled cysteine-rich domain0.7168Inherited
EF-hand modules in multidomain proteins0.7168Inherited
Transforming growth factor (TGF)-beta0.7168Inherited
Ubiquitin-related0.7566Inherited
MSP-like0.7808Inherited
Bacterial lipase0.7837Inherited
Cdc48 N-terminal domain-like0.7837Inherited
MIT domain0.7837Inherited
H-NOX domain0.7837Inherited
Voltage-gated potassium channels0.8035Inherited
PAZ domain0.828Inherited
Protein kinases, catalytic subunit0.8416Inherited
Fibronectin type III0.8468Inherited
LIM domain0.8545Inherited
Calmodulin-like0.9019Inherited
Glutathione S-transferase (GST), C-terminal domain0.9062Inherited
Leucine zipper domain0.9172Inherited
Adenylyl and guanylyl cyclase catalytic domain0.9618Inherited
Ribonuclease PH domain 2-like0.9638Inherited
Ribonuclease PH domain 1-like0.9638Inherited
Nuclear receptor ligand-binding domain0.9799Inherited
L-arabinose binding protein-like0.9828Inherited
Calponin-homology domain, CH-domain0.9903Inherited
N-acetyl transferase, NAT1Inherited
B-box zinc-binding domain1Inherited
Glutathione peroxidase-like1Inherited
F-box domain1Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains1Inherited
Cyclophilin (peptidylprolyl isomerase)1Inherited
Histone lysine methyltransferases1Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain1Inherited
DnaQ-like 3'-5' exonuclease1Inherited
Cold shock DNA-binding domain-like1Inherited
C-type lectin domain1Inherited
RING finger domain, C3HC41Inherited
Rhodopsin-like1Inherited
Choline/Carnitine O-acyltransferase1Inherited
Nuclear receptor1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
LEM domain0Direct
Arginase/deacetylase0Direct
Complement control module/SCR domain0Direct
dsRNA-binding domain-like0Direct
Integrin domains0Direct
Terpenoid synthases0Direct
PurM N-terminal domain-like0Direct
ARID-like0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
Aldolase0Direct
Heme-dependent peroxidases0Direct
HCP-like0Direct
S-adenosylmethionine synthetase0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
Oxysterol-binding protein-like0Direct
AN1-like Zinc finger0Direct
Cdc48 domain 2-like0Direct
Activating enzymes of the ubiquitin-like proteins0Direct
PurM C-terminal domain-like0Direct
ThrRS/AlaRS common domain0Direct
beta-lactamase/transpeptidase-like0Direct
GYF domain0Direct
Phoshotransferase/anion transport protein0Direct
lambda repressor-like DNA-binding domains0Direct
Ribosomal protein L10Direct
WGR domain-like0Direct
Ribulose-phoshate binding barrel0Direct
Class II aaRS ABD-related0Direct
PLP-binding barrel0Direct
Sec63 N-terminal domain-like0Direct
Restriction endonuclease-like0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Succinyl-CoA synthetase domains0Direct
Elafin-like0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Hect, E3 ligase catalytic domain0Direct
Proton glutamate symport protein0Direct
FtsH protease domain-like0Direct
TK C-terminal domain-like0Direct
Glutathione synthetase ATP-binding domain-like0Direct
F1F0 ATP synthase subunit C0Direct
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)0Direct
PreATP-grasp domain0Direct
MgtE membrane domain-like0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Ribokinase-like0Direct
CRAL/TRIO N-terminal domain0Direct
CAD & PB1 domains0Direct
Cullin repeat-like0Direct
Band 7/SPFH domain0Direct
Fibrinogen C-terminal domain-like0Direct
Cadherin-like0Direct
alpha-catenin/vinculin-like0Direct
Molybdenum cofactor-binding domain0Direct
GHMP Kinase, C-terminal domain0Direct
Clathrin adaptor appendage domain0Direct
LDH C-terminal domain-like0Direct
ADP-ribosylation0Direct
Transducin (heterotrimeric G protein), gamma chain0Direct
HMG-box0Direct
YWTD domain0Direct
SPOC domain-like0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Putative DNA-binding domain0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
Tricorn protease domain 20Direct
Ribosomal protein L10-like0Direct
CBD9-like0Direct
Nucleoporin domain0Direct
GAS2 domain-like0Direct
Zn-finger domain of Sec23/240Direct
GINS helical bundle-like0Direct
R3H domain0Direct
Troponin coil-coiled subunits0Direct
Galactose mutarotase-like0Direct
Clc chloride channel0Direct
Radical SAM enzymes0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
Nucleotidyltransferase0Direct
Cation efflux protein cytoplasmic domain-like0Direct
TGS-like0Direct
Thiolase-like0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
PEBP-like0Direct
Hedgehog/intein (Hint) domain0Direct
alpha/beta knot0Direct
SWIB/MDM2 domain0Direct
Spectrin repeat0Direct
Sec1/munc18-like (SM) proteins0Direct
Phosphoglucomutase, first 3 domains0Direct
Carbon-nitrogen hydrolase0Direct
Sec7 domain0Direct
t-snare proteins0Direct
HSP90 C-terminal domain0Direct
SMAD/FHA domain0Direct
Phosphoglucomutase, C-terminal domain0Direct
PEP carboxykinase-like0Direct
Rudiment single hybrid motif0Direct
Actin-like ATPase domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Periplasmic binding protein-like II0Direct
Ribosomal proteins S24e, L23 and L15e0Direct
Diaminopimelate epimerase-like0Direct
Domain of poly(ADP-ribose) polymerase0Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase0Direct
Families 57/38 glycoside transferase middle domain0Direct
Alpha-L RNA-binding motif0Direct
Chromo domain-like0Direct
PABC (PABP) domain0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Mitochondrial carrier0Direct
Lamin A/C globular tail domain0Direct
PEP carboxykinase N-terminal domain0Direct
Tim10-like0Direct
Hormone receptor domain0Direct
DNA repair protein MutS, domain III0Direct
Helical domain of Sec23/240Direct
Translational machinery components0Direct
Invertebrate chitin-binding proteins0Direct
PLC-like phosphodiesterases0Direct
14-3-3 protein0Direct
3-carboxy-cis,cis-mucoante lactonizing enzyme0Direct
MOSC N-terminal domain-like0Direct
Terpenoid cyclases/Protein prenyltransferases0Direct
PAP/OAS1 substrate-binding domain0Direct
Subdomain of clathrin and coatomer appendage domain0Direct
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase0Direct
VPS9 domain0Direct
Formate/glycerate dehydrogenase catalytic domain-like0Direct
PGBD-like0Direct
Heme-dependent catalase-like0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Nop domain0Direct
Polo-box domain0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Carboxypeptidase regulatory domain-like0Direct
Ribosomal L27 protein-like0Direct
CO dehydrogenase ISP C-domain like0Direct
Profilin (actin-binding protein)0Direct
LysM domain0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Ribosomal protein S100Direct
Cu,Zn superoxide dismutase-like0Direct
Tubulin C-terminal domain-like0Direct
ISP domain0Direct
Pepsin inhibitor-30Direct
eIF4e-like0Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0Direct
Protease propeptides/inhibitors0Direct
Phosphoenolpyruvate/pyruvate domain0Direct
Bacterial exopeptidase dimerisation domain0Direct
FAD-dependent thiol oxidase0Direct
FF domain0Direct
Calcium-dependent phosphotriesterase0Direct
Thyroglobulin type-1 domain0Direct
Composite domain of metallo-dependent hydrolases0Direct
Citrate synthase0Direct
Cytochrome c0Direct
PK beta-barrel domain-like0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Chaperone J-domain0Direct
Single hybrid motif0Direct
L-aspartase-like0Direct
Transducin (alpha subunit), insertion domain0Direct
ClpP/crotonase0Direct
MFPT repeat-like0Direct
2Fe-2S ferredoxin-like0Direct
Glycolipid transfer protein, GLTP0Direct
SAND domain-like0Direct
Cystatin/monellin0Direct
Subtilisin-like0Direct
Second domain of FERM0Direct
SIS domain0Direct
Hypothetical protein c14orf129, hspc2100Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
MIR domain0Direct
Blood coagulation inhibitor (disintegrin)0Direct
SAICAR synthase-like0Direct
Surp module (SWAP domain)0Direct
ALDH-like0Direct
Integrin alpha N-terminal domain0Direct
Skp1 dimerisation domain-like0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
Intermediate filament protein, coiled coil region0Direct
DEATH domain0Direct
GroEL apical domain-like0Direct
GAT-like domain0Direct
Zn-binding ribosomal proteins0Direct
L30e-like0Direct
Nucleoside diphosphate kinase, NDK0Direct
Doublecortin (DC)0Direct
PHM/PNGase F0Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0Direct
RBP11-like subunits of RNA polymerase0Direct
Acid phosphatase/Vanadium-dependent haloperoxidase0Direct
HSP40/DnaJ peptide-binding domain0Direct
WWE domain0Direct
Small-conductance potassium channel0Direct
ValRS/IleRS/LeuRS editing domain0Direct
PYP-like sensor domain (PAS domain)0Direct
ArfGap/RecO-like zinc finger0Direct
Rap/Ran-GAP0Direct
PAP/Archaeal CCA-adding enzyme, C-terminal domain0Direct
Creatinase/prolidase N-terminal domain0Direct
Tubulin nucleotide-binding domain-like0Direct
Chitinase insertion domain0Direct
Annexin0Direct
SMAD MH1 domain0Direct
Pentein0Direct
Cullin homology domain0Direct
HSP20-like chaperones0Direct
PIN domain-like0Direct
ENTH/VHS domain0Direct
Tubby C-terminal domain-like0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
GroEL equatorial domain-like0Direct
BEACH domain0Direct
Galactose oxidase, central domain0Direct
cAMP-binding domain-like0Direct
Ferritin-like0Direct
Carbohydrate phosphatase0Direct
Class I glutamine amidotransferase-like0Direct
Ran binding protein zinc finger-like0Direct
Smc hinge domain0Direct
Outer arm dynein light chain 10Direct
YbiA-like0Direct
GroES-like0Direct
GroEL-intermediate domain like0Direct
JAB1/MPN domain0Direct
PH domain-like0.000001237Direct
Histone-fold0.00005847Direct
PDZ domain-like0.00751Inherited
TPR-like0.01008Inherited
ARM repeat0.01669Inherited
"Winged helix" DNA-binding domain0.01729Inherited
SH2 domain0.02908Inherited
WD40 repeat-like0.03301Inherited
Acetyl-CoA synthetase-like0.05166Inherited
Homeodomain-like0.0527Inherited
EGF/Laminin0.05316Inherited
Cyclin-like0.05787Inherited
CCCH zinc finger0.06479Inherited
Ankyrin repeat0.06687Inherited
Galactose-binding domain-like0.08001Inherited
Translation proteins0.08112Inherited
RNI-like0.09616Inherited
ABC transporter transmembrane region0.0963Inherited
HLH, helix-loop-helix DNA-binding domain0.0963Inherited
Calcium ATPase, transmembrane domain M0.1135Inherited
SH3-domain0.1218Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.1268Inherited
Regulator of G-protein signaling, RGS0.1268Inherited
Class II aaRS and biotin synthetases0.1417Inherited
Calcium ATPase, transduction domain A0.1417Inherited
Quinoprotein alcohol dehydrogenase-like0.1582Inherited
Multidrug efflux transporter AcrB transmembrane domain0.165Inherited
(Trans)glycosidases0.1722Inherited
Cytochrome P4500.1722Inherited
P-loop containing nucleoside triphosphate hydrolases0.1735Inherited
WW domain0.1764Inherited
DBL homology domain (DH-domain)0.1764Inherited
Cysteine proteinases0.2131Inherited
BRCT domain0.2133Inherited
Multidrug resistance efflux transporter EmrE0.2195Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.2396Inherited
POZ domain0.2441Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.2445Inherited
Bromodomain0.2445Inherited
SNARE-like0.2717Inherited
SAM/Pointed domain0.2732Inherited
Lipocalins0.2732Inherited
RNA-binding domain, RBD0.2774Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.2832Inherited
Cation efflux protein transmembrane domain-like0.3362Inherited
FYVE/PHD zinc finger0.3454Inherited
Acid proteases0.3466Inherited
Cysteine-rich domain0.3604Inherited
Nicotinic receptor ligand binding domain-like0.3827Inherited
FKBP-like0.4146Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.4196Inherited
HAD-like0.4212Inherited
Myosin rod fragments0.459Inherited
DHS-like NAD/FAD-binding domain0.459Inherited
PRTase-like0.459Inherited
Cystine-knot cytokines0.5001Inherited
Sm-like ribonucleoproteins0.5001Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.5074Inherited
Riboflavin synthase domain-like0.5074Inherited
Calpain large subunit, middle domain (domain III)0.5074Inherited
Growth factor receptor domain0.5453Inherited
Voltage-gated potassium channels0.5495Inherited
UBC-like0.5497Inherited
Seven-hairpin glycosidases0.5626Inherited
alpha/beta-Hydrolases0.6065Inherited
Lipovitellin-phosvitin complex, superhelical domain0.6189Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.6189Inherited
Osmotin, thaumatin-like protein0.6189Inherited
KA1-like0.6189Inherited
GTPase activation domain, GAP0.6805Inherited
S15/NS1 RNA-binding domain0.6849Inherited
Frizzled cysteine-rich domain0.6849Inherited
GST C-terminal domain-like0.7052Inherited
PAZ domain0.7079Inherited
MIT domain0.757Inherited
ADC-like0.757Inherited
Fibronectin type III0.7649Inherited
PapD-like0.7663Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.7683Inherited
Protein kinase-like (PK-like)0.8203Inherited
Ribonuclease H-like0.8634Inherited
Ubiquitin-like0.8634Inherited
Leucine zipper domain0.8665Inherited
Nucleic acid-binding proteins0.9072Inherited
p53-like transcription factors0.9166Inherited
MFS general substrate transporter0.9241Inherited
Immunoglobulin0.9257Inherited
Ribonuclease PH domain 2-like0.9411Inherited
EF-hand0.9424Inherited
FAD/NAD(P)-binding domain0.9609Inherited
beta-beta-alpha zinc fingers0.9625Inherited
Periplasmic binding protein-like I0.9638Inherited
Thioredoxin-like0.9726Inherited
Nucleotide cyclase0.9757Inherited
Ribosomal protein S5 domain 2-like0.9791Inherited
Eukaryotic type KH-domain (KH-domain type I)0.9812Inherited
SET domain0.9885Inherited
CoA-dependent acyltransferases0.9949Inherited
Cyclophilin-like0.9949Inherited
Saposin1Inherited
Bet v1-like1Inherited
Acyl-CoA dehydrogenase NM domain-like1Inherited
B-box zinc-binding domain1Inherited
UBA-like1Inherited
DNA/RNA polymerases1Inherited
Acyl-CoA dehydrogenase C-terminal domain-like1Inherited
Clavaminate synthase-like1Inherited
Calponin-homology domain, CH-domain1Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase1Inherited
E set domains1Inherited
Nucleotidylyl transferase1Inherited
Nuclear receptor ligand-binding domain1Inherited
Family A G protein-coupled receptor-like1Inherited
F-box domain1Inherited
Ligand-binding domain in the NO signalling and Golgi transport1Inherited
RING/U-box1Inherited
Insulin-like1Inherited
Translation proteins SH3-like domain1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0Direct
    52540,46785
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0Direct
    48403,52151
  • 48403 - Ankyrin repeat
  • 52151 - FabD/lysophospholipase-like
  • 0Direct
    51735,50129
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 0Direct
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0Direct
    54897,53187
  • 54897 - Protease propeptides/inhibitors
  • 53187 - Zn-dependent exopeptidases
  • 0Direct
    52540,81271
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 81271 - TGS-like
  • 0Direct
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0Direct
    52518,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    144232,82199
  • 144232 - HIT/MYND zinc finger-like
  • 82199 - SET domain
  • 0Direct
    57938,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    54211,55060
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55060 - GHMP Kinase, C-terminal domain
  • 0Direct
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0Direct
    82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    57903,82199
  • 57903 - FYVE/PHD zinc finger
  • 82199 - SET domain
  • 0Direct
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    51905,56425
  • 51905 - FAD/NAD(P)-binding domain
  • 56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
  • 0Direct
    53187,49464
  • 53187 - Zn-dependent exopeptidases
  • 49464 - Carboxypeptidase regulatory domain-like
  • 0Direct
    52743,49785
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    141673,50800
  • 141673 - MOSC N-terminal domain-like
  • 50800 - PK beta-barrel domain-like
  • 0Direct
    57414,57414
  • 57414 - Hairpin loop containing domain-like
  • 57414 - Hairpin loop containing domain-like
  • 0Direct
    52283,51735
  • 52283 - Formate/glycerate dehydrogenase catalytic domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0Direct
    51556,51338
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0Direct
    54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    81383,50978
  • 81383 - F-box domain
  • 50978 - WD40 repeat-like
  • 0Direct
    48425,50729
  • 48425 - Sec7 domain
  • 50729 - PH domain-like
  • 0Direct
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    57362,57362
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 0Direct
    47741,56176
  • 47741 - CO dehydrogenase ISP C-domain like
  • 56176 - FAD-binding/transporter-associated domain-like
  • 0Direct
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0Direct
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0Direct
    52047,52047
  • 52047 - RNI-like
  • 52047 - RNI-like
  • 0Direct
    48179,48179
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0Direct
    57756,50630
  • 57756 - Retrovirus zinc finger-like domains
  • 50630 - Acid proteases
  • 0Direct
    47769,47769
  • 47769 - SAM/Pointed domain
  • 47769 - SAM/Pointed domain
  • 0Direct
    47587,56399
  • 47587 - Domain of poly(ADP-ribose) polymerase
  • 56399 - ADP-ribosylation
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    51445,51445
  • 51445 - (Trans)glycosidases
  • 51445 - (Trans)glycosidases
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    55729,55729
  • 55729 - Acyl-CoA N-acyltransferases (Nat)
  • 55729 - Acyl-CoA N-acyltransferases (Nat)
  • 0Direct
    53738,53738
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 0Direct
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0Direct
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0Direct
    55920,46785
  • 55920 - Creatinase/aminopeptidase
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    53901,53901
  • 53901 - Thiolase-like
  • 53901 - Thiolase-like
  • 0Direct
    46938,52087
  • 46938 - CRAL/TRIO N-terminal domain
  • 52087 - CRAL/TRIO domain
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0Direct
    57196,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53187,55031
  • 53187 - Zn-dependent exopeptidases
  • 55031 - Bacterial exopeptidase dimerisation domain
  • 0Direct
    50978,50998
  • 50978 - WD40 repeat-like
  • 50998 - Quinoprotein alcohol dehydrogenase-like
  • 0Direct
    74650,51445
  • 74650 - Galactose mutarotase-like
  • 51445 - (Trans)glycosidases
  • 0Direct
    55394,55394
  • 55394 - Bactericidal permeability-increasing protein, BPI
  • 55394 - Bactericidal permeability-increasing protein, BPI
  • 0Direct
    56112,48371
  • 56112 - Protein kinase-like (PK-like)
  • 48371 - ARM repeat
  • 0Direct
    81383,52047
  • 81383 - F-box domain
  • 52047 - RNI-like
  • 0Direct
    57625,57625
  • 57625 - Invertebrate chitin-binding proteins
  • 57625 - Invertebrate chitin-binding proteins
  • 0Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    64356,49447
  • 64356 - SNARE-like
  • 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor
  • 0Direct
    54236,54236
  • 54236 - Ubiquitin-like
  • 54236 - Ubiquitin-like
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    57756,57756
  • 57756 - Retrovirus zinc finger-like domains
  • 57756 - Retrovirus zinc finger-like domains
  • 0Direct
    49742,49742
  • 49742 - PHM/PNGase F
  • 49742 - PHM/PNGase F
  • 0Direct
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0Direct
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    54897,52743
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    56672,100879
  • 56672 - DNA/RNA polymerases
  • 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain
  • 0Direct
    57889,50729
  • 57889 - Cysteine-rich domain
  • 50729 - PH domain-like
  • 0Direct
    48464,89009
  • 48464 - ENTH/VHS domain
  • 89009 - GAT-like domain
  • 0Direct
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0Direct
    51735,56327
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 56327 - LDH C-terminal domain-like
  • 0Direct
    88713,88688
  • 88713 - Glycoside hydrolase/deacetylase
  • 88688 - Families 57/38 glycoside transferase middle domain
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    101690,53098
  • 101690 - PAZ domain
  • 53098 - Ribonuclease H-like
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0Direct
    103473,103473
  • 103473 - MFS general substrate transporter
  • 103473 - MFS general substrate transporter
  • 0Direct
    53474,53474
  • 53474 - alpha/beta-Hydrolases
  • 53474 - alpha/beta-Hydrolases
  • 0Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0Direct
    50129,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    161093,161093
  • 161093 - MgtE membrane domain-like
  • 161093 - MgtE membrane domain-like
  • 0Direct
    56059,52210
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52210 - Succinyl-CoA synthetase domains
  • 0Direct
    81698,81698
  • 81698 - FF domain
  • 81698 - FF domain
  • 0Direct
    46785,46785
  • 46785 - "Winged helix" DNA-binding domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    50044,52540
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    51735,55347
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 0Direct
    51338,51556
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 0Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0Direct
    51445,54556
  • 51445 - (Trans)glycosidases
  • 54556 - Chitinase insertion domain
  • 0Direct
    68923,53795
  • 68923 - PEP carboxykinase N-terminal domain
  • 53795 - PEP carboxykinase-like
  • 0Direct
    57889,48350
  • 57889 - Cysteine-rich domain
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    52540,140990
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 140990 - FtsH protease domain-like
  • 0Direct
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    141739,141739
  • 141739 - MFPT repeat-like
  • 141739 - MFPT repeat-like
  • 0Direct
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0Direct
    81301,81631
  • 81301 - Nucleotidyltransferase
  • 81631 - PAP/OAS1 substrate-binding domain
  • 0Direct
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0Direct
    47203,47203
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    47473,103506
  • 47473 - EF-hand
  • 103506 - Mitochondrial carrier
  • 0Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0Direct
    53738,55957
  • 53738 - Phosphoglucomutase, first 3 domains
  • 55957 - Phosphoglucomutase, C-terminal domain
  • 0Direct
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0Direct
    81631,55003
  • 81631 - PAP/OAS1 substrate-binding domain
  • 55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain
  • 0Direct
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0Direct
    57850,117839
  • 57850 - RING/U-box
  • 117839 - WWE domain
  • 0Direct
    49348,55711
  • 49348 - Clathrin adaptor appendage domain
  • 55711 - Subdomain of clathrin and coatomer appendage domain
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    56601,48403
  • 56601 - beta-lactamase/transpeptidase-like
  • 48403 - Ankyrin repeat
  • 0Direct
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0Direct
    52518,52922
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 0Direct
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0Direct
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0Direct
    55326,56042
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 0Direct
    55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0Direct
    81324,81327
  • 81324 - Voltage-gated potassium channels
  • 81327 - Small-conductance potassium channel
  • 0Direct
    50156,50044
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 0Direct
    54665,56003
  • 54665 - CO dehydrogenase molybdoprotein N-domain-like
  • 56003 - Molybdenum cofactor-binding domain
  • 0Direct
    54292,47741
  • 54292 - 2Fe-2S ferredoxin-like
  • 47741 - CO dehydrogenase ISP C-domain like
  • 0Direct
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    51971,54373
  • 51971 - Nucleotide-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 0Direct
    56112,82615
  • 56112 - Protein kinase-like (PK-like)
  • 82615 - Polo-box domain
  • 0Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    161111,160240
  • 161111 - Cation efflux protein transmembrane domain-like
  • 160240 - Cation efflux protein cytoplasmic domain-like
  • 0Direct
    47576,47576
  • 47576 - Calponin-homology domain, CH-domain
  • 47576 - Calponin-homology domain, CH-domain
  • 0Direct
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0Direct
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0Direct
    57863,48403
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0Direct
    52047,48371
  • 52047 - RNI-like
  • 48371 - ARM repeat
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    82615,82615
  • 82615 - Polo-box domain
  • 82615 - Polo-box domain
  • 0Direct
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0Direct
    52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00258Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.01167Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0963Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.1015Inherited
    56112,55073
  • 56112 - Protein kinase-like (PK-like)
  • 55073 - Nucleotide cyclase
  • 0.1268Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.1268Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.1404Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.1968Inherited
    56436,49854
  • 56436 - C-type lectin-like
  • 49854 - Spermadhesin, CUB domain
  • 0.232Inherited
    51735,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0.2445Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.2445Inherited
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0.2717Inherited
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.3021Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.3021Inherited
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.3362Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.3466Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.4196Inherited
    48403,48403
  • 48403 - Ankyrin repeat
  • 48403 - Ankyrin repeat
  • 0.459Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.4605Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.4667Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 0.5318Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.5626Inherited
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0.6189Inherited
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0.6189Inherited
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.6189Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.6494Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.6849Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.757Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.7776Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.8294Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.8657Inherited
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0.9411Inherited
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.9466Inherited
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 1Inherited
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 1Inherited
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 1Inherited
    53300,56436
  • 53300 - vWA-like
  • 56436 - C-type lectin-like
  • 1Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48452,48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0Direct
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    56436,49854,49854
  • 56436 - C-type lectin-like
  • 49854 - Spermadhesin, CUB domain
  • 49854 - Spermadhesin, CUB domain
  • 0Direct
    50044,50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0Direct
    57414,57414,57414
  • 57414 - Hairpin loop containing domain-like
  • 57414 - Hairpin loop containing domain-like
  • 57414 - Hairpin loop containing domain-like
  • 0Direct
    63411,63411,63411
  • 63411 - LuxS/MPP-like metallohydrolase
  • 63411 - LuxS/MPP-like metallohydrolase
  • 63411 - LuxS/MPP-like metallohydrolase
  • 0Direct
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    46938,52087,101576
  • 46938 - CRAL/TRIO N-terminal domain
  • 52087 - CRAL/TRIO domain
  • 101576 - Supernatant protein factor (SPF), C-terminal domain
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    55973,55973,55973
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 55973 - S-adenosylmethionine synthetase
  • 0Direct
    50156,50044,52540
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    56112,82615,82615
  • 56112 - Protein kinase-like (PK-like)
  • 82615 - Polo-box domain
  • 82615 - Polo-box domain
  • 0Direct
    54292,47741,56176
  • 54292 - 2Fe-2S ferredoxin-like
  • 47741 - CO dehydrogenase ISP C-domain like
  • 56176 - FAD-binding/transporter-associated domain-like
  • 0Direct
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    48371,48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    53738,53738,55957
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 55957 - Phosphoglucomutase, C-terminal domain
  • 0Direct
    82895,82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0Direct
    49785,49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    57362,57362,57362
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 0Direct
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0Direct
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0Direct
    57625,57625,57625
  • 57625 - Invertebrate chitin-binding proteins
  • 57625 - Invertebrate chitin-binding proteins
  • 57625 - Invertebrate chitin-binding proteins
  • 0Direct
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0Direct
    50249,50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0Direct
    74650,51445,51011
  • 74650 - Galactose mutarotase-like
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0Direct
    56645,47203,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    51735,48179,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    57938,49493,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    57567,57567,57567
  • 57567 - Serine protease inhibitors
  • 57567 - Serine protease inhibitors
  • 57567 - Serine protease inhibitors
  • 0Direct
    53738,53738,53738
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 0Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0Direct
    54897,52743,49785
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0Direct
    81301,81631,55003
  • 81301 - Nucleotidyltransferase
  • 81631 - PAP/OAS1 substrate-binding domain
  • 55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain
  • 0Direct
    48726,49265,48726
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    54928,54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    50129,51735,50129
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.1417Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.374Inherited
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.374Inherited
    56436,56436,49854
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 49854 - Spermadhesin, CUB domain
  • 0.3745Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.459Inherited
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.6189Inherited
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.8595Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9704Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 1Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 1Inherited


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