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Worm Phenotype (WP): cell homeostasis metabolism variant

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Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Variant [WBPhenotype:0000886] <2>
+ + 2:   physiology variant [WBPhenotype:0000519] <14>(510|587) (510|248|68)
+ 1:   cell physiology variant [WBPhenotype:0000536] <36>(149|149) (150|64|19)
0:   cell homeostasis metabolism variant [WBPhenotype:0000585] <12>(60|54) (60|23|12)
- 1:   cell stress response variant [WBPhenotype:0000142] <12>(20|17) (20|7|3)
- 1:   protein metabolism variant [WBPhenotype:0001644] <9>(30|26) (30|15|8)
- 1:   DNA metabolism variant [WBPhenotype:0000732] <7>(1|0) (1|0|0)
- 1:   chromosome segregation variant [WBPhenotype:0000773] <6>(10|9) (10|2|0)
- 1:   RNA metabolism variant [WBPhenotype:0001827] <5>(4|2) (4|0|0)
- 1:   autophagy variant [WBPhenotype:0000736] <3>(0|1) (0|0|0)
- 1:   organelle metabolism variant [WBPhenotype:0001283] <3>(1|2) (1|0|0)
- 1:   cell acidification variant [WBPhenotype:0001393] <2>(0|0) (0|0|0)
- 1:   chromosome instability [WBPhenotype:0000000] <2>(1|1) (1|0|0)
- 1:   telomere homeostasis variant [WBPhenotype:0001673] <1>(0|0) (0|0|0)
- 1:   endo lysosomal degradation pathway defective [WBPhenotype:0002236](0|0) (0|0|0)
- 1:   integrity of membranous organelles defective early emb [WBPhenotype:0000767](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Lipovitellin-phosvitin complex, superhelical domain0Direct
RBP11-like subunits of RNA polymerase0Direct
LEM domain0Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
Heme-dependent catalase-like0Direct
Histone-fold0Direct
HSP90 C-terminal domain0Direct
Restriction endonuclease-like0Direct
The spindle assembly checkpoint protein mad20Direct
Arginase/deacetylase0.00000001346Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0.000007944Direct
DHS-like NAD/FAD-binding domain0.00002582Direct
Di-copper centre-containing domain0.0003316Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0004279Direct
ADC-like0.0005189Direct
Cdc48 domain 2-like0.0005189Direct
Integrin domains0.0005189Direct
PLC-like phosphodiesterases0.0007109Direct
RING/U-box0.004685Inherited
SET domain0.009862Inherited
Nucleic acid-binding proteins0.01179Inherited
Protein kinase-like (PK-like)0.01607Inherited
Cyclin-like0.01689Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.01913Inherited
Smc hinge domain0.02062Inherited
Calpain large subunit, middle domain (domain III)0.02062Inherited
Hect, E3 ligase catalytic domain0.04204Inherited
Zn-binding ribosomal proteins0.04204Inherited
P-loop containing nucleoside triphosphate hydrolases0.0574Inherited
L30e-like0.07622Inherited
F1F0 ATP synthase subunit C0.08446Inherited
RNA-binding domain, RBD0.1322Inherited
GroEL-intermediate domain like0.1671Inherited
GroEL equatorial domain-like0.1671Inherited
Transducin (alpha subunit), insertion domain0.1758Inherited
Immunoglobulin0.2053Inherited
Voltage-gated potassium channels0.2344Inherited
Clavaminate synthase-like0.2512Inherited
GroEL apical domain-like0.2827Inherited
Cysteine-rich domain0.3037Inherited
Translation proteins0.3089Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.3736Inherited
EF-hand0.3883Inherited
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0.3974Inherited
Quinoprotein alcohol dehydrogenase-like0.4052Inherited
Spectrin repeat0.4052Inherited
DNA/RNA polymerases0.4079Inherited
Saposin0.464Inherited
Metallo-dependent phosphatases0.5285Inherited
Chromo domain-like0.5423Inherited
PLP-dependent transferases0.6431Inherited
Sm-like ribonucleoproteins0.6652Inherited
BRCT domain0.6906Inherited
"Winged helix" DNA-binding domain0.6966Inherited
PH domain-like0.8573Inherited
FYVE/PHD zinc finger0.8642Inherited
SH3-domain0.9209Inherited
Homeodomain-like1Inherited
POZ domain1Inherited
Skp1 dimerisation domain-like1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Sir2 family of transcriptional regulators0Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
Nucleosome core histones0Direct
Heme-dependent catalases0Direct
Lipovitellin-phosvitin complex, superhelical domain0Direct
Hsp90 middle domain0Direct
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
XPF/Rad1/Mus81 nuclease0Direct
Smc hinge domain0Direct
RNA-polymerase beta0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Histone deacetylase, HDAC0Direct
Mammalian PLC0Direct
LEM domain0Direct
HSP90 C-terminal domain0Direct
Integrin domains0Direct
Arginine methyltransferase0Direct
PLC-like (P variant)0.00000005806Direct
Cyclin0.0004155Direct
Cdc48 domain 2-like0.0007595Direct
Hemocyanin middle domain0.0007595Direct
Cdc48 N-terminal domain-like0.0007595Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.000818Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.001863Inherited
RING finger domain, C3HC40.004086Inherited
I set domains0.01002Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.01231Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.01718Inherited
Calpain large subunit, middle domain (domain III)0.01718Inherited
Calpain large subunit, catalytic domain (domain II)0.01718Inherited
Motor proteins0.02866Inherited
Histone lysine methyltransferases0.0304Inherited
Hect, E3 ligase catalytic domain0.03573Inherited
Pleckstrin-homology domain (PH domain)0.05527Inherited
Protein kinases, catalytic subunit0.05646Inherited
Tandem AAA-ATPase domain0.05722Inherited
Group II chaperonin (CCT, TRIC), intermediate domain0.0734Inherited
F1F0 ATP synthase subunit C0.0734Inherited
EF-hand modules in multidomain proteins0.0734Inherited
Elongation factors0.09003Inherited
PHD domain0.1711Inherited
Cold shock DNA-binding domain-like0.1982Inherited
Spectrin repeat0.2406Inherited
Group II chaperonin (CCT, TRIC), ATPase domain0.2406Inherited
Transducin (alpha subunit), insertion domain0.2522Inherited
Canonical RBD0.2751Inherited
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0.3723Inherited
LIM domain0.3723Inherited
Group II chaperonin (CCT, TRIC), apical domain0.3802Inherited
Voltage-gated potassium channels0.42Inherited
ABC transporter ATPase domain-like0.4553Inherited
G proteins0.6206Inherited
BTB/POZ domain1Inherited
Skp1 dimerisation domain-like1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Lipovitellin-phosvitin complex; beta-sheet shell regions0Direct
Heme-dependent catalase-like0Direct
LEM domain0Direct
HSP90 C-terminal domain0Direct
RBP11-like subunits of RNA polymerase0Direct
Lipovitellin-phosvitin complex, superhelical domain0Direct
The spindle assembly checkpoint protein mad20Direct
Restriction endonuclease-like0Direct
Histone-fold0Direct
Arginase/deacetylase0.00000001073Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0.000006462Direct
DHS-like NAD/FAD-binding domain0.00002108Direct
Di-copper centre-containing domain0.0002733Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0003533Direct
Cdc48 domain 2-like0.0004294Direct
Integrin domains0.0004294Direct
ADC-like0.0004294Direct
PLC-like phosphodiesterases0.00059Direct
RING/U-box0.003977Inherited
SET domain0.008477Inherited
Nucleic acid-binding proteins0.01016Inherited
Protein kinase-like (PK-like)0.01394Inherited
Cyclin-like0.01467Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.01663Inherited
Calpain large subunit, middle domain (domain III)0.01795Inherited
Smc hinge domain0.01795Inherited
Zn-binding ribosomal proteins0.0371Inherited
Hect, E3 ligase catalytic domain0.0371Inherited
P-loop containing nucleoside triphosphate hydrolases0.05105Inherited
L30e-like0.06827Inherited
F1F0 ATP synthase subunit C0.07591Inherited
RNA-binding domain, RBD0.1203Inherited
GroEL equatorial domain-like0.153Inherited
GroEL-intermediate domain like0.153Inherited
Transducin (alpha subunit), insertion domain0.1613Inherited
Immunoglobulin0.1892Inherited
Voltage-gated potassium channels0.2171Inherited
Clavaminate synthase-like0.2334Inherited
GroEL apical domain-like0.2641Inherited
Cysteine-rich domain0.2845Inherited
Translation proteins0.2896Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.3532Inherited
EF-hand0.3678Inherited
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0.377Inherited
Quinoprotein alcohol dehydrogenase-like0.3845Inherited
Spectrin repeat0.3845Inherited
DNA/RNA polymerases0.3872Inherited
Saposin0.4429Inherited
Metallo-dependent phosphatases0.5066Inherited
Chromo domain-like0.5205Inherited
PLP-dependent transferases0.6214Inherited
Sm-like ribonucleoproteins0.6435Inherited
BRCT domain0.6696Inherited
"Winged helix" DNA-binding domain0.6758Inherited
PH domain-like0.8409Inherited
FYVE/PHD zinc finger0.848Inherited
SH3-domain0.9063Inherited
POZ domain1Inherited
Skp1 dimerisation domain-like1Inherited
Homeodomain-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0003533Direct
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0.0004294Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.0004294Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.0009351Direct
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0.01795Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.01843Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.09244Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.1117Inherited
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.153Inherited
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.153Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1613Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.2447Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.377Inherited
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48371,48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0003533Direct
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.0371Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.09244Inherited
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.153Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.377Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.5339Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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