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Worm Phenotype (WP): cell homeostasis metabolism variant

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Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Variant [WBPhenotype:0000886] <5>
+ + 2:   physiology variant [WBPhenotype:0000519] <7>(494|573) (495|248|68)
+ 1:   cell physiology variant [WBPhenotype:0000536] <26>(152|155) (154|66|17)
+ 1:   blast cell physiology variant [WBPhenotype:0000985] <26>(152|155) (154|66|17)
0:   cell homeostasis metabolism variant [WBPhenotype:0000585] <12>(66|61) (66|26|11)
- 1:   cell stress response variant [WBPhenotype:0000142] <12>(28|24) (28|10|3)
- 1:   protein metabolism variant [WBPhenotype:0001644] <10>(28|24) (28|15|8)
- 1:   DNA metabolism variant [WBPhenotype:0000732] <7>(1|0) (1|0|0)
- 1:   RNA metabolism variant [WBPhenotype:0001827] <6>(1|1) (1|1|0)
- 1:   chromosome segregation variant [WBPhenotype:0000773] <6>(11|9) (11|2|0)
- 1:   organelle metabolism variant [WBPhenotype:0001283] <3>(1|2) (1|0|0)
- 1:   autophagy variant [WBPhenotype:0000736] <2>(1|0) (1|0|0)
- 1:   cell acidification variant [WBPhenotype:0001393] <2>(0|0) (0|0|0)
- 1:   chromosome instability [WBPhenotype:0000000] <2>(1|1) (1|0|0)
- 1:   telomere homeostasis variant [WBPhenotype:0001673] <1>(0|0) (0|0|0)
- 1:   endo lysosomal degradation pathway defective [WBPhenotype:0002236](0|0) (0|0|0)
- 1:   integrity of membranous organelles defective early emb [WBPhenotype:0000767](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Restriction endonuclease-like0Direct
HSP90 C-terminal domain0Direct
The spindle assembly checkpoint protein mad20Direct
Histone-fold0Direct
RBP11-like subunits of RNA polymerase0Direct
LEM domain0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0.000005316Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0000163Direct
ADC-like0.0004013Direct
Integrin domains0.0004013Direct
Cdc48 domain 2-like0.0004013Direct
Cu,Zn superoxide dismutase-like0.0004013Direct
PLC-like phosphodiesterases0.0008205Direct
SET domain0.005417Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.015Inherited
Lipovitellin-phosvitin complex, superhelical domain0.015Inherited
Smc hinge domain0.015Inherited
Calpain large subunit, middle domain (domain III)0.015Inherited
CCCH zinc finger0.01537Inherited
RING/U-box0.01617Inherited
Protein kinase-like (PK-like)0.01977Inherited
Cyclin-like0.02222Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.02524Inherited
P-loop containing nucleoside triphosphate hydrolases0.02981Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.06897Inherited
F1F0 ATP synthase subunit C0.06897Inherited
5' to 3' exonuclease, C-terminal subdomain0.06897Inherited
Lipocalins0.1011Inherited
PIN domain-like0.1073Inherited
Nucleic acid-binding proteins0.1172Inherited
GroEL-intermediate domain like0.1309Inherited
GroEL equatorial domain-like0.1309Inherited
Transducin (alpha subunit), insertion domain0.1434Inherited
Immunoglobulin0.1452Inherited
Voltage-gated potassium channels0.1628Inherited
Translation proteins0.1659Inherited
cAMP-binding domain-like0.2179Inherited
GroEL apical domain-like0.2299Inherited
EF-hand0.3033Inherited
Cysteine-rich domain0.337Inherited
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0.3457Inherited
Spectrin repeat0.346Inherited
Cysteine proteinases0.3647Inherited
E set domains0.3768Inherited
PLP-dependent transferases0.4077Inherited
Saposin0.4133Inherited
Clavaminate synthase-like0.4133Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.46Inherited
Metallo-dependent phosphatases0.4608Inherited
DNA/RNA polymerases0.4778Inherited
Quinoprotein alcohol dehydrogenase-like0.4778Inherited
Ubiquitin-like0.4784Inherited
Activating enzymes of the ubiquitin-like proteins0.4973Inherited
"Winged helix" DNA-binding domain0.5456Inherited
Nucleotidylyl transferase0.5474Inherited
Sm-like ribonucleoproteins0.5994Inherited
BRCT domain0.6332Inherited
RNA-binding domain, RBD0.6352Inherited
FYVE/PHD zinc finger0.6491Inherited
SNARE-like0.7077Inherited
PH domain-like0.8092Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.8682Inherited
Thioredoxin-like0.9001Inherited
Homeodomain-like0.9424Inherited
POZ domain1Inherited
Skp1 dimerisation domain-like1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Hsp90 middle domain0Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Integrin domains0Direct
HSP90 C-terminal domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
Nucleosome core histones0Direct
Smc hinge domain0Direct
RNA-polymerase beta0Direct
Arginine methyltransferase0Direct
LEM domain0Direct
Mammalian PLC0Direct
PLC-like (P variant)0.00000003438Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.00004178Direct
Cdc48 N-terminal domain-like0.0006292Direct
Cdc48 domain 2-like0.0006292Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L0.0006292Direct
Cu,Zn superoxide dismutase-like0.0006292Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.001194Inherited
Cyclin0.001603Inherited
Fatty acid binding protein-like0.0044Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.01294Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.01294Inherited
Calpain large subunit, catalytic domain (domain II)0.01294Inherited
Lipovitellin-phosvitin complex, superhelical domain0.01294Inherited
Calpain large subunit, middle domain (domain III)0.01294Inherited
RING finger domain, C3HC40.01894Inherited
Histone lysine methyltransferases0.02092Inherited
PHD domain0.02651Inherited
Erythroid transcription factor GATA-10.02824Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.03174Inherited
CCCH zinc finger0.03207Inherited
I set domains0.03843Inherited
Elongation factors0.03843Inherited
Motor proteins0.04757Inherited
Protein kinases, catalytic subunit0.06047Inherited
F1F0 ATP synthase subunit C0.06113Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.06113Inherited
5' to 3' exonuclease, C-terminal subdomain0.06113Inherited
Group II chaperonin (CCT, TRIC), intermediate domain0.06113Inherited
5' to 3' exonuclease catalytic domain0.06113Inherited
EF-hand modules in multidomain proteins0.06113Inherited
Pleckstrin-homology domain (PH domain)0.07874Inherited
FAD/NAD-linked reductases, N-terminal and central domains0.1201Inherited
Tandem AAA-ATPase domain0.1503Inherited
Group II chaperonin (CCT, TRIC), ATPase domain0.2034Inherited
Spectrin repeat0.2034Inherited
Transducin (alpha subunit), insertion domain0.2205Inherited
Glutathione peroxidase-like0.279Inherited
LIM domain0.3284Inherited
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0.3284Inherited
Group II chaperonin (CCT, TRIC), apical domain0.3299Inherited
Voltage-gated potassium channels0.3448Inherited
ABC transporter ATPase domain-like0.367Inherited
Clathrin adaptor core protein0.4792Inherited
Proteasome subunits0.533Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.5554Inherited
Glutathione S-transferase (GST), N-terminal domain0.6253Inherited
Canonical RBD0.8911Inherited
Skp1 dimerisation domain-like1Inherited
BTB/POZ domain1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Restriction endonuclease-like0Direct
RBP11-like subunits of RNA polymerase0Direct
LEM domain0Direct
Histone-fold0Direct
The spindle assembly checkpoint protein mad20Direct
HSP90 C-terminal domain0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0.000004287Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0000132Direct
Cu,Zn superoxide dismutase-like0.0003294Direct
Cdc48 domain 2-like0.0003294Direct
ADC-like0.0003294Direct
Integrin domains0.0003294Direct
PLC-like phosphodiesterases0.0006776Direct
SET domain0.004578Inherited
Lipovitellin-phosvitin complex, superhelical domain0.01289Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.01289Inherited
Calpain large subunit, middle domain (domain III)0.01289Inherited
Smc hinge domain0.01289Inherited
CCCH zinc finger0.01321Inherited
RING/U-box0.01392Inherited
Protein kinase-like (PK-like)0.01709Inherited
Cyclin-like0.01927Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.02196Inherited
P-loop containing nucleoside triphosphate hydrolases0.02604Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.06143Inherited
F1F0 ATP synthase subunit C0.06143Inherited
5' to 3' exonuclease, C-terminal subdomain0.06143Inherited
Lipocalins0.09113Inherited
PIN domain-like0.09683Inherited
Nucleic acid-binding proteins0.106Inherited
GroEL equatorial domain-like0.1188Inherited
GroEL-intermediate domain like0.1188Inherited
Transducin (alpha subunit), insertion domain0.1306Inherited
Immunoglobulin0.1323Inherited
Voltage-gated potassium channels0.1487Inherited
Translation proteins0.1516Inherited
cAMP-binding domain-like0.2009Inherited
GroEL apical domain-like0.2125Inherited
EF-hand0.2838Inherited
Cysteine-rich domain0.3168Inherited
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0.3254Inherited
Spectrin repeat0.3257Inherited
Cysteine proteinases0.344Inherited
E set domains0.3558Inherited
PLP-dependent transferases0.3863Inherited
Clavaminate synthase-like0.3918Inherited
Saposin0.3918Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.4381Inherited
Metallo-dependent phosphatases0.4389Inherited
DNA/RNA polymerases0.4561Inherited
Quinoprotein alcohol dehydrogenase-like0.4561Inherited
Ubiquitin-like0.4567Inherited
Activating enzymes of the ubiquitin-like proteins0.4753Inherited
"Winged helix" DNA-binding domain0.5232Inherited
Nucleotidylyl transferase0.5249Inherited
Sm-like ribonucleoproteins0.5771Inherited
BRCT domain0.611Inherited
RNA-binding domain, RBD0.613Inherited
FYVE/PHD zinc finger0.627Inherited
SNARE-like0.6872Inherited
PH domain-like0.7915Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.8527Inherited
Thioredoxin-like0.8858Inherited
Homeodomain-like0.9298Inherited
Skp1 dimerisation domain-like1Inherited
POZ domain1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0000132Direct
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0.0003294Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.0003294Direct
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.004599Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.006586Inherited
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.01289Inherited
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0.01289Inherited
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0.01289Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.01335Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.01335Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.0377Inherited
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0.06143Inherited
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.1188Inherited
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.1188Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1306Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.1419Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.2009Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.3254Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 0.6556Inherited
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0000132Direct
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.01289Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.02825Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.06795Inherited
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.1188Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.3254Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.4753Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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