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Worm Phenotype (WP): cell homeostasis metabolism variant

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Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Variant [WBPhenotype:0000886] <4>
+ + 2:   physiology variant [WBPhenotype:0000519] <7>(489|563) (489|241|65)
+ 1:   blast cell physiology variant [WBPhenotype:0000985] <26>(152|154) (153|67|17)
+ 1:   cell physiology variant [WBPhenotype:0000536] <26>(152|154) (153|67|17)
0:   cell homeostasis metabolism variant [WBPhenotype:0000585] <12>(65|61) (65|26|11)
- 1:   cell stress response variant [WBPhenotype:0000142] <12>(28|24) (28|9|3)
- 1:   protein metabolism variant [WBPhenotype:0001644] <10>(28|24) (28|15|8)
- 1:   DNA metabolism variant [WBPhenotype:0000732] <7>(1|0) (1|0|0)
- 1:   RNA metabolism variant [WBPhenotype:0001827] <6>(1|1) (1|1|0)
- 1:   chromosome segregation variant [WBPhenotype:0000773] <6>(11|9) (11|2|0)
- 1:   organelle metabolism variant [WBPhenotype:0001283] <3>(1|2) (1|0|0)
- 1:   autophagy variant [WBPhenotype:0000736] <2>(0|0) (0|0|0)
- 1:   cell acidification variant [WBPhenotype:0001393] <2>(0|0) (0|0|0)
- 1:   chromosome instability [WBPhenotype:0000000] <2>(1|1) (1|0|0)
- 1:   telomere homeostasis variant [WBPhenotype:0001673] <1>(0|0) (0|0|0)
- 1:   endo lysosomal degradation pathway defective [WBPhenotype:0002236](0|0) (0|0|0)
- 1:   integrity of membranous organelles defective early emb [WBPhenotype:0000767](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
HSP90 C-terminal domain0Direct
RBP11-like subunits of RNA polymerase0Direct
LEM domain0Direct
The spindle assembly checkpoint protein mad20Direct
Restriction endonuclease-like0Direct
Histone-fold0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0.000005778Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.00001805Direct
Integrin domains0.0004224Direct
ADC-like0.0004224Direct
Cdc48 domain 2-like0.0004224Direct
Cu,Zn superoxide dismutase-like0.0004224Direct
PLC-like phosphodiesterases0.000513Direct
SET domain0.005499Inherited
Calpain large subunit, middle domain (domain III)0.01497Inherited
Lipovitellin-phosvitin complex, superhelical domain0.01497Inherited
Smc hinge domain0.01497Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.01497Inherited
CCCH zinc finger0.01542Inherited
Protein kinase-like (PK-like)0.01765Inherited
RING/U-box0.02179Inherited
Cyclin-like0.02247Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.02578Inherited
P-loop containing nucleoside triphosphate hydrolases0.03932Inherited
5' to 3' exonuclease, C-terminal subdomain0.06851Inherited
F1F0 ATP synthase subunit C0.06851Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.06851Inherited
Lipocalins0.107Inherited
PIN domain-like0.1072Inherited
Nucleic acid-binding proteins0.1198Inherited
GroEL equatorial domain-like0.1309Inherited
GroEL-intermediate domain like0.1309Inherited
Transducin (alpha subunit), insertion domain0.1498Inherited
Immunoglobulin0.1581Inherited
Translation proteins0.1669Inherited
Voltage-gated potassium channels0.1785Inherited
cAMP-binding domain-like0.2174Inherited
Clavaminate synthase-like0.2176Inherited
GroEL apical domain-like0.2296Inherited
Cysteine-rich domain0.3368Inherited
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0.3445Inherited
Spectrin repeat0.3453Inherited
E set domains0.354Inherited
Cysteine proteinases0.3667Inherited
EF-hand0.4136Inherited
Saposin0.4206Inherited
PLP-dependent transferases0.4576Inherited
Metallo-dependent phosphatases0.461Inherited
Quinoprotein alcohol dehydrogenase-like0.4746Inherited
DNA/RNA polymerases0.4746Inherited
FYVE/PHD zinc finger0.4787Inherited
Activating enzymes of the ubiquitin-like proteins0.4929Inherited
"Winged helix" DNA-binding domain0.497Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.5423Inherited
Nucleotidylyl transferase0.5438Inherited
Sm-like ribonucleoproteins0.5937Inherited
BRCT domain0.6268Inherited
RNA-binding domain, RBD0.6344Inherited
SNARE-like0.7015Inherited
PH domain-like0.8067Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.8619Inherited
Thioredoxin-like0.9078Inherited
Homeodomain-like0.9341Inherited
POZ domain1Inherited
Skp1 dimerisation domain-like1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
XPF/Rad1/Mus81 nuclease0Direct
LEM domain0Direct
Arginine methyltransferase0Direct
Smc hinge domain0Direct
RNA-polymerase beta0Direct
Mammalian PLC0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
Integrin domains0Direct
HSP90 C-terminal domain0Direct
Nucleosome core histones0Direct
Hsp90 middle domain0Direct
PLC-like (P variant)0.00000003676Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0000434Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L0.0006363Direct
Cdc48 N-terminal domain-like0.0006363Direct
Cdc48 domain 2-like0.0006363Direct
Cu,Zn superoxide dismutase-like0.0006363Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.00118Inherited
Cyclin0.001587Inherited
Fatty acid binding protein-like0.004527Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.01276Inherited
Calpain large subunit, catalytic domain (domain II)0.01276Inherited
Lipovitellin-phosvitin complex, superhelical domain0.01276Inherited
Calpain large subunit, middle domain (domain III)0.01276Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.01276Inherited
PHD domain0.01327Inherited
RING finger domain, C3HC40.01999Inherited
Histone lysine methyltransferases0.02074Inherited
Erythroid transcription factor GATA-10.02786Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.03266Inherited
CCCH zinc finger0.03318Inherited
Elongation factors0.038Inherited
I set domains0.038Inherited
Motor proteins0.04723Inherited
Protein kinases, catalytic subunit0.05175Inherited
Group II chaperonin (CCT, TRIC), intermediate domain0.06032Inherited
EF-hand modules in multidomain proteins0.06032Inherited
5' to 3' exonuclease catalytic domain0.06032Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.06032Inherited
5' to 3' exonuclease, C-terminal subdomain0.06032Inherited
F1F0 ATP synthase subunit C0.06032Inherited
Pleckstrin-homology domain (PH domain)0.07817Inherited
FAD/NAD-linked reductases, N-terminal and central domains0.1185Inherited
Tandem AAA-ATPase domain0.1973Inherited
Spectrin repeat0.201Inherited
Group II chaperonin (CCT, TRIC), ATPase domain0.201Inherited
Transducin (alpha subunit), insertion domain0.2224Inherited
Glutathione peroxidase-like0.2813Inherited
LIM domain0.3247Inherited
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0.3247Inherited
Group II chaperonin (CCT, TRIC), apical domain0.3263Inherited
Voltage-gated potassium channels0.354Inherited
ABC transporter ATPase domain-like0.3633Inherited
Clathrin adaptor core protein0.4723Inherited
Proteasome subunits0.5259Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.5471Inherited
Glutathione S-transferase (GST), N-terminal domain0.6259Inherited
Canonical RBD0.8767Inherited
Skp1 dimerisation domain-like1Inherited
BTB/POZ domain1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Restriction endonuclease-like0Direct
HSP90 C-terminal domain0Direct
The spindle assembly checkpoint protein mad20Direct
RBP11-like subunits of RNA polymerase0Direct
LEM domain0Direct
Histone-fold0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0.000004721Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0000148Direct
Cdc48 domain 2-like0.0003507Direct
Cu,Zn superoxide dismutase-like0.0003507Direct
ADC-like0.0003507Direct
Integrin domains0.0003507Direct
PLC-like phosphodiesterases0.0004265Direct
SET domain0.004687Inherited
Smc hinge domain0.01294Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.01294Inherited
Calpain large subunit, middle domain (domain III)0.01294Inherited
Lipovitellin-phosvitin complex, superhelical domain0.01294Inherited
CCCH zinc finger0.01334Inherited
Protein kinase-like (PK-like)0.01531Inherited
RING/U-box0.019Inherited
Cyclin-like0.01961Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.02255Inherited
P-loop containing nucleoside triphosphate hydrolases0.03473Inherited
F1F0 ATP synthase subunit C0.06122Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.06122Inherited
5' to 3' exonuclease, C-terminal subdomain0.06122Inherited
Lipocalins0.09676Inherited
PIN domain-like0.09694Inherited
Nucleic acid-binding proteins0.1086Inherited
GroEL equatorial domain-like0.1192Inherited
GroEL-intermediate domain like0.1192Inherited
Transducin (alpha subunit), insertion domain0.1369Inherited
Immunoglobulin0.1447Inherited
Translation proteins0.153Inherited
Voltage-gated potassium channels0.1639Inherited
cAMP-binding domain-like0.2009Inherited
Clavaminate synthase-like0.2011Inherited
GroEL apical domain-like0.2126Inherited
Cysteine-rich domain0.3169Inherited
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0.3244Inherited
Spectrin repeat0.3252Inherited
E set domains0.3336Inherited
Cysteine proteinases0.3463Inherited
EF-hand0.3923Inherited
Saposin0.3991Inherited
PLP-dependent transferases0.4362Inherited
Metallo-dependent phosphatases0.4395Inherited
Quinoprotein alcohol dehydrogenase-like0.4528Inherited
DNA/RNA polymerases0.4528Inherited
FYVE/PHD zinc finger0.4569Inherited
Activating enzymes of the ubiquitin-like proteins0.4708Inherited
"Winged helix" DNA-binding domain0.4749Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.5202Inherited
Nucleotidylyl transferase0.5218Inherited
Sm-like ribonucleoproteins0.5714Inherited
BRCT domain0.6048Inherited
RNA-binding domain, RBD0.6125Inherited
SNARE-like0.681Inherited
PH domain-like0.7879Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.8452Inherited
Thioredoxin-like0.8928Inherited
Homeodomain-like0.9202Inherited
POZ domain1Inherited
Skp1 dimerisation domain-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0000148Direct
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0.0003507Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.0003507Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.006684Inherited
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0.01294Inherited
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0.01294Inherited
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.01294Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.01436Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.01436Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.03801Inherited
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0.06122Inherited
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.1192Inherited
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.1192Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1369Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.143Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.2009Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.3244Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 0.6671Inherited
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0000148Direct
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.01294Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.0283Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.06827Inherited
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.1192Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.3244Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.4708Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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