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Worm Phenotype (WP): drug response variant

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   Variant [WBPhenotype:0000886] <5>
+ + + + + 5:   physiology variant [WBPhenotype:0000519] <7>(494|573) (495|248|68)
+ + + + 4:   organism physiology variant [WBPhenotype:0000576] <10>(354|423) (357|200|60)
+ + + 3:   organism homeostasis metabolism variant [WBPhenotype:0000577] <17>(343|412) (348|198|59)
+ + 2:   organism environmental stimulus response variant [WBPhenotype:0000738] <16>(115|108) (120|53|16)
+ 1:   chemical response variant [WBPhenotype:0000523] <11>(66|58) (68|26|6)
0:   drug response variant [WBPhenotype:0000631] <27>(42|37) (44|17|2)
- 1:   drug resistant [WBPhenotype:0000011] <22>(17|16) (19|7|1)
- 1:   drug hypersensitive [WBPhenotype:0000010] <18>(8|10) (8|4|1)
- 1:   egg laying response to drug variant [WBPhenotype:0001101] <6>(2|4) (3|0|0)
- 1:   serotonin response variant [WBPhenotype:0001232] <5>(2|4) (4|0|0)
- 1:   muscimol response variant [WBPhenotype:0002047] <4>(0|0) (0|0|0)
- 1:   acetylcholinesterase inhibitor response variant [WBPhenotype:0001290] <3>(15|13) (17|6|0)
- 1:   abamectin repsonse variant [WBPhenotype:0002049] <2>(0|0) (0|0|0)
- 1:   anesthetic response variant [WBPhenotype:0000627] <2>(2|1) (2|0|0)
- 1:   calcium channel modulator response variant [WBPhenotype:0000558] <2>(0|0) (0|0|0)
- 1:   drug adaptation variant [WBPhenotype:0000555] <2>(1|1) (1|0|0)
- 1:   levamisole response variant [WBPhenotype:0000845] <2>(2|2) (2|1|0)
- 1:   nicotine response variant [WBPhenotype:0001573] <2>(10|9) (10|4|1)
- 1:   pore forming toxin response variant [WBPhenotype:0002058] <2>(1|1) (1|0|0)
- 1:   tunicamycin response variant [WBPhenotype:0000359] <2>(0|0) (0|0|0)
- 1:   DMPP response variant [WBPhenotype:0000681] <1>(2|2) (2|1|0)
- 1:   adrenergic receptor antagonist response variant [WBPhenotype:0001337] <1>(2|1) (2|0|0)
- 1:   anticonvulsant response variant [WBPhenotype:0001614] <1>(0|0) (0|0|0)
- 1:   hydroxyurea response variant [WBPhenotype:0001878] <1>(2|1) (2|0|0)
- 1:   inhibitor of serotonin uptake variant [WBPhenotype:0001598] <1>(2|1) (2|0|0)
- 1:   ivermectin response variant [WBPhenotype:0001856] <1>(1|1) (1|2|0)
- 1:   benomyl response variant [WBPhenotype:0001854](0|0) (0|0|0)
- 1:   drug induced life span variant [WBPhenotype:0001871](0|0) (0|0|0)
- 1:   drug induced locomotion variant [WBPhenotype:0001872](0|0) (0|0|0)
- 1:   drug susceptible [WBPhenotype:0002109](0|0) (0|0|0)
- 1:   drug withdrawal response variant [WBPhenotype:0001842](0|1) (0|0|0)
- 1:   ligand gated channel activity variant [WBPhenotype:0001783](0|0) (0|0|0)
- 1:   xenotoxicity suppressor [WBPhenotype:0002384](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nicotinic receptor ligand binding domain-like0.0000006523Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0000009448Direct
Spectrin repeat0.0001439Direct
Troponin coil-coiled subunits0.0002707Direct
Quinoprotein alcohol dehydrogenase-like0.0006605Direct
PDZ domain-like0.001276Inherited
DBL homology domain (DH-domain)0.003151Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.003919Inherited
SAM/Pointed domain0.004876Inherited
ENTH/VHS domain0.005593Inherited
t-snare proteins0.006305Inherited
PRTase-like0.006305Inherited
Immunoglobulin0.006521Inherited
SNARE-like0.03217Inherited
Bromodomain0.04042Inherited
TPR-like0.04183Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.04183Inherited
Leucine zipper domain0.04497Inherited
SH3-domain0.06098Inherited
Cystine-knot cytokines0.07156Inherited
SMAD/FHA domain0.08154Inherited
Tubulin C-terminal domain-like0.1637Inherited
Tubulin nucleotide-binding domain-like0.1637Inherited
PH domain-like0.2087Inherited
SH2 domain0.245Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.249Inherited
ABC transporter transmembrane region0.249Inherited
Calcium ATPase, transduction domain A0.249Inherited
Calcium ATPase, transmembrane domain M0.249Inherited
Myosin rod fragments0.3209Inherited
Protein kinase-like (PK-like)0.3459Inherited
Cysteine-rich domain0.3736Inherited
HAD-like0.3736Inherited
Voltage-gated potassium channels0.5189Inherited
cAMP-binding domain-like0.7407Inherited
P-loop containing nucleoside triphosphate hydrolases0.7709Inherited
beta-beta-alpha zinc fingers0.8633Inherited
Nucleic acid-binding proteins0.8991Inherited
"Winged helix" DNA-binding domain1Inherited
Family A G protein-coupled receptor-like1Inherited
Transducin (alpha subunit), insertion domain1Inherited
Homeodomain-like1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Quinoprotein alcohol dehydrogenase-like0Direct
Nicotinic receptor ligand binding domain-like0.0000005485Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0000005485Direct
Calcium ATPase, transmembrane domain M0.0001658Direct
Spectrin repeat0.0001658Direct
PDZ domain0.0004816Direct
Synaptotagmin-like (S variant)0.0005087Direct
Transforming growth factor (TGF)-beta0.0006219Direct
Pyridoxal-dependent decarboxylase0.001063Inherited
Clathrin coat assembly domain0.003481Inherited
Phosphoribosyltransferases (PRTases)0.003481Inherited
DBL homology domain (DH-domain)0.006723Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.007328Inherited
t-snare proteins0.0102Inherited
WD40-repeat0.02401Inherited
I set domains0.04666Inherited
SH3-domain0.04916Inherited
Bromodomain0.06322Inherited
FYVE, a phosphatidylinositol-3-phosphate binding domain0.06322Inherited
ABC transporter transmembrane region0.06774Inherited
Leucine zipper domain0.07738Inherited
Meta-cation ATPase, catalytic domain P0.09793Inherited
Tubulin, C-terminal domain0.1414Inherited
Tubulin, GTPase domain0.1414Inherited
Rhodopsin-like0.1843Inherited
Calcium ATPase, transduction domain A0.2196Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.2196Inherited
Pleckstrin-homology domain (PH domain)0.2505Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.2878Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.2902Inherited
Protein kinases, catalytic subunit0.3074Inherited
ABC transporter ATPase domain-like0.3375Inherited
Voltage-gated potassium channels0.3728Inherited
PLC-like (P variant)0.602Inherited
cAMP-binding domain0.7092Inherited
G proteins0.9975Inherited
Transducin (alpha subunit), insertion domain1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nicotinic receptor ligand binding domain-like0.0000005225Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0000007578Direct
Spectrin repeat0.0001174Direct
Troponin coil-coiled subunits0.0002217Direct
Quinoprotein alcohol dehydrogenase-like0.0005444Direct
PDZ domain-like0.001057Inherited
DBL homology domain (DH-domain)0.002646Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.003299Inherited
SAM/Pointed domain0.004118Inherited
ENTH/VHS domain0.004728Inherited
PRTase-like0.005337Inherited
t-snare proteins0.005337Inherited
Immunoglobulin0.005523Inherited
SNARE-like0.02814Inherited
Bromodomain0.0355Inherited
TPR-like0.03676Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.03676Inherited
Leucine zipper domain0.03958Inherited
SH3-domain0.05412Inherited
Cystine-knot cytokines0.06379Inherited
SMAD/FHA domain0.07296Inherited
Insulin-like0.1047Inherited
Tubulin nucleotide-binding domain-like0.1495Inherited
Tubulin C-terminal domain-like0.1495Inherited
PH domain-like0.1921Inherited
WW domain0.2129Inherited
SH2 domain0.227Inherited
ABC transporter transmembrane region0.2309Inherited
Calcium ATPase, transduction domain A0.2309Inherited
Calcium ATPase, transmembrane domain M0.2309Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.2309Inherited
Myosin rod fragments0.301Inherited
Protein kinase-like (PK-like)0.3256Inherited
Cysteine-rich domain0.3528Inherited
HAD-like0.3528Inherited
Voltage-gated potassium channels0.4963Inherited
cAMP-binding domain-like0.721Inherited
P-loop containing nucleoside triphosphate hydrolases0.7522Inherited
beta-beta-alpha zinc fingers0.8476Inherited
Nucleic acid-binding proteins0.8847Inherited
Homeodomain-like0.9953Inherited
Family A G protein-coupled receptor-like1Inherited
"Winged helix" DNA-binding domain1Inherited
Transducin (alpha subunit), insertion domain1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.0000007578Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.00006946Direct
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.00009134Direct
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.00009134Direct
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.0004546Direct
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.00221Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.003299Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.003299Inherited
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.003299Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.07296Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.1047Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.1273Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.1322Inherited
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.1495Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2309Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.2309Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.0008384Direct
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.07296Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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