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Worm Phenotype (WP): drug response variant

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Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   Variant [WBPhenotype:0000886] <2>
+ + + + + 5:   physiology variant [WBPhenotype:0000519] <14>(510|587) (510|248|69)
+ + + + 4:   organism physiology variant [WBPhenotype:0000576] <9>(369|431) (372|193|57)
+ + + 3:   organism homeostasis metabolism variant [WBPhenotype:0000577] <16>(361|421) (363|190|56)
+ + 2:   organism environmental stimulus response variant [WBPhenotype:0000738] <15>(137|128) (138|57|18)
+ 1:   chemical response variant [WBPhenotype:0000523] <17>(79|73) (80|30|9)
0:   drug response variant [WBPhenotype:0000631] <27>(48|43) (49|15|2)
- 1:   drug resistant [WBPhenotype:0000011] <22>(15|12) (15|5|1)
- 1:   drug hypersensitive [WBPhenotype:0000010] <18>(10|12) (10|4|1)
- 1:   egg laying response to drug variant [WBPhenotype:0001101] <6>(2|4) (3|0|0)
- 1:   serotonin response variant [WBPhenotype:0001232] <5>(2|4) (4|0|0)
- 1:   muscimol response variant [WBPhenotype:0002047] <4>(0|0) (0|0|0)
- 1:   acetylcholinesterase inhibitor response variant [WBPhenotype:0001290] <3>(15|14) (16|5|0)
- 1:   anesthetic response variant [WBPhenotype:0000627] <3>(12|10) (12|1|0)
- 1:   abamectin repsonse variant [WBPhenotype:0002049] <2>(0|0) (0|0|0)
- 1:   calcium channel modulator response variant [WBPhenotype:0000558] <2>(0|0) (0|0|0)
- 1:   drug adaptation variant [WBPhenotype:0000555] <2>(1|1) (1|0|0)
- 1:   levamisole response variant [WBPhenotype:0000845] <2>(1|1) (1|0|0)
- 1:   nicotine response variant [WBPhenotype:0001573] <2>(10|9) (10|4|1)
- 1:   pore forming toxin response variant [WBPhenotype:0002058] <2>(1|1) (1|0|0)
- 1:   tunicamycin response variant [WBPhenotype:0000359] <2>(0|0) (0|0|0)
- 1:   DMPP response variant [WBPhenotype:0000681] <1>(2|2) (2|1|0)
- 1:   adrenergic receptor antagonist response variant [WBPhenotype:0001337] <1>(2|1) (2|0|0)
- 1:   anticonvulsant response variant [WBPhenotype:0001614] <1>(0|0) (0|0|0)
- 1:   hydroxyurea response variant [WBPhenotype:0001878] <1>(1|1) (2|0|0)
- 1:   inhibitor of serotonin uptake variant [WBPhenotype:0001598] <1>(3|1) (3|0|0)
- 1:   ivermectin response variant [WBPhenotype:0001856] <1>(1|1) (1|2|0)
- 1:   benomyl response variant [WBPhenotype:0001854](0|0) (0|0|0)
- 1:   drug induced life span variant [WBPhenotype:0001871](0|0) (0|0|0)
- 1:   drug induced locomotion variant [WBPhenotype:0001872](0|0) (0|0|0)
- 1:   drug susceptible [WBPhenotype:0002109](0|0) (0|0|0)
- 1:   drug withdrawal response variant [WBPhenotype:0001842](0|1) (0|0|0)
- 1:   ligand gated channel activity variant [WBPhenotype:0001783](0|0) (0|0|0)
- 1:   xenotoxicity suppressor [WBPhenotype:0002384](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Transducin (alpha subunit), insertion domain0Direct
Nicotinic receptor ligand binding domain-like0.00000002133Direct
Neurotransmitter-gated ion-channel transmembrane pore0.00000003455Direct
Ligand-binding domain in the NO signalling and Golgi transport0.000006588Direct
Spectrin repeat0.0002492Direct
Troponin coil-coiled subunits0.0004297Direct
Immunoglobulin0.001305Inherited
PDZ domain-like0.003166Inherited
PYP-like sensor domain (PAS domain)0.005468Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.005974Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.006923Inherited
WD40 repeat-like0.007135Inherited
SAM/Pointed domain0.008365Inherited
ENTH/VHS domain0.008463Inherited
PRTase-like0.008883Inherited
TPR-like0.009521Inherited
SNF-like0.01528Inherited
P-loop containing nucleoside triphosphate hydrolases0.03381Inherited
SNARE-like0.04389Inherited
Protein kinase-like (PK-like)0.0814Inherited
Tubulin C-terminal domain-like0.08205Inherited
Tubulin nucleotide-binding domain-like0.08205Inherited
Cystine-knot cytokines0.09459Inherited
SH3-domain0.1044Inherited
Voltage-gated potassium channels0.1095Inherited
EF-hand0.1118Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.1163Inherited
Calcium ATPase, transmembrane domain M0.1163Inherited
Calcium ATPase, transduction domain A0.1163Inherited
cAMP-binding domain-like0.1687Inherited
Cysteine-rich domain0.1835Inherited
t-snare proteins0.2057Inherited
Myosin rod fragments0.2057Inherited
HMG-box0.2057Inherited
Transducin (heterotrimeric G protein), gamma chain0.2057Inherited
Bromodomain0.2057Inherited
PH domain-like0.2107Inherited
Homeodomain-like0.2274Inherited
DBL homology domain (DH-domain)0.2407Inherited
HAD-like0.3193Inherited
Leucine zipper domain0.3364Inherited
Nucleic acid-binding proteins0.8713Inherited
"Winged helix" DNA-binding domain0.8803Inherited
beta-beta-alpha zinc fingers0.9368Inherited
Nucleotide cyclase0.9795Inherited
ABC transporter transmembrane region0.9994Inherited
Periplasmic binding protein-like I1Inherited
Family A G protein-coupled receptor-like1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Quinoprotein alcohol dehydrogenase-like0Direct
Transducin (alpha subunit), insertion domain0Direct
Neurotransmitter-gated ion-channel transmembrane pore0.00000004812Direct
Nicotinic receptor ligand binding domain-like0.00000004812Direct
H-NOX domain0.0002066Direct
Eps15 homology domain (EH domain)0.0002066Direct
G proteins0.0002069Direct
Calcium ATPase, transmembrane domain M0.0002878Direct
Spectrin repeat0.0002878Direct
Transforming growth factor (TGF)-beta0.0009016Direct
Synaptotagmin-like (S variant)0.0009321Direct
PDZ domain0.001406Inherited
Phosphoribosyltransferases (PRTases)0.004964Inherited
Clathrin coat assembly domain0.004964Inherited
WD40-repeat0.009701Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.01106Inherited
I set domains0.0184Inherited
SNF-like0.02101Inherited
Protein kinases, catalytic subunit0.04626Inherited
Meta-cation ATPase, catalytic domain P0.048Inherited
Tubulin, C-terminal domain0.07683Inherited
Tubulin, GTPase domain0.07683Inherited
Pleckstrin-homology domain (PH domain)0.1037Inherited
SH3-domain0.1037Inherited
Calcium ATPase, transduction domain A0.1119Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.1119Inherited
Pyridoxal-dependent decarboxylase0.1223Inherited
cAMP-binding domain0.1624Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.1624Inherited
Homeodomain0.1752Inherited
HMG-box0.1946Inherited
t-snare proteins0.1946Inherited
Transducin (heterotrimeric G protein), gamma chain0.1946Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.1946Inherited
Bromodomain0.1946Inherited
Rhodopsin-like0.2261Inherited
DBL homology domain (DH-domain)0.2327Inherited
Voltage-gated potassium channels0.24Inherited
Leucine zipper domain0.3268Inherited
PLC-like (P variant)0.4236Inherited
ABC transporter transmembrane region0.9592Inherited
Adenylyl and guanylyl cyclase catalytic domain0.9816Inherited
ABC transporter ATPase domain-like1Inherited


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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Transducin (alpha subunit), insertion domain0Direct
Nicotinic receptor ligand binding domain-like0.00000001702Direct
Neurotransmitter-gated ion-channel transmembrane pore0.00000002761Direct
Ligand-binding domain in the NO signalling and Golgi transport0.000005355Direct
Spectrin repeat0.0002049Direct
Troponin coil-coiled subunits0.0003546Direct
Immunoglobulin0.001089Inherited
PDZ domain-like0.002672Inherited
PYP-like sensor domain (PAS domain)0.004649Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.005085Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.005906Inherited
WD40 repeat-like0.00609Inherited
SAM/Pointed domain0.007163Inherited
ENTH/VHS domain0.007251Inherited
PRTase-like0.007618Inherited
TPR-like0.008177Inherited
SNF-like0.01323Inherited
SMAD/FHA domain0.02794Inherited
P-loop containing nucleoside triphosphate hydrolases0.02973Inherited
SNARE-like0.03876Inherited
Protein kinase-like (PK-like)0.07306Inherited
Tubulin nucleotide-binding domain-like0.07366Inherited
Tubulin C-terminal domain-like0.07366Inherited
Cystine-knot cytokines0.08527Inherited
SH3-domain0.09433Inherited
Voltage-gated potassium channels0.09903Inherited
EF-hand0.1012Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.1054Inherited
Calcium ATPase, transduction domain A0.1054Inherited
Calcium ATPase, transmembrane domain M0.1054Inherited
cAMP-binding domain-like0.1546Inherited
Cysteine-rich domain0.1685Inherited
t-snare proteins0.1897Inherited
Myosin rod fragments0.1897Inherited
Transducin (heterotrimeric G protein), gamma chain0.1897Inherited
HMG-box0.1897Inherited
Bromodomain0.1897Inherited
PH domain-like0.1945Inherited
Homeodomain-like0.2104Inherited
DBL homology domain (DH-domain)0.2231Inherited
HAD-like0.2998Inherited
Leucine zipper domain0.3167Inherited
Nucleic acid-binding proteins0.855Inherited
"Winged helix" DNA-binding domain0.8645Inherited
beta-beta-alpha zinc fingers0.9231Inherited
Nucleotide cyclase0.9681Inherited
ABC transporter transmembrane region0.9895Inherited
Family A G protein-coupled receptor-like1Inherited
Periplasmic binding protein-like I1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.00000002761Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.0001025Direct
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.0001473Direct
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.0001473Direct
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.0003735Direct
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.0007253Direct
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.005085Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.02794Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.03129Inherited
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.07366Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.1054Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.1187Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.3167Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.9895Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.001222Inherited
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.02794Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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