SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Worm Phenotype (WP): drug response variant

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   Variant [WBPhenotype:0000886] <2>
+ + + + + 5:   physiology variant [WBPhenotype:0000519] <14>(510|587) (510|248|68)
+ + + + 4:   organism physiology variant [WBPhenotype:0000576] <9>(369|431) (372|193|56)
+ + + 3:   organism homeostasis metabolism variant [WBPhenotype:0000577] <16>(361|421) (363|190|55)
+ + 2:   organism environmental stimulus response variant [WBPhenotype:0000738] <15>(138|128) (139|57|18)
+ 1:   chemical response variant [WBPhenotype:0000523] <17>(80|73) (81|30|9)
0:   drug response variant [WBPhenotype:0000631] <27>(49|43) (50|15|2)
- 1:   drug resistant [WBPhenotype:0000011] <22>(16|12) (16|5|1)
- 1:   drug hypersensitive [WBPhenotype:0000010] <18>(10|12) (10|4|1)
- 1:   egg laying response to drug variant [WBPhenotype:0001101] <6>(2|4) (3|0|0)
- 1:   serotonin response variant [WBPhenotype:0001232] <5>(2|4) (4|0|0)
- 1:   muscimol response variant [WBPhenotype:0002047] <4>(0|0) (0|0|0)
- 1:   acetylcholinesterase inhibitor response variant [WBPhenotype:0001290] <3>(16|14) (17|5|0)
- 1:   anesthetic response variant [WBPhenotype:0000627] <3>(12|10) (12|1|0)
- 1:   abamectin repsonse variant [WBPhenotype:0002049] <2>(0|0) (0|0|0)
- 1:   calcium channel modulator response variant [WBPhenotype:0000558] <2>(0|0) (0|0|0)
- 1:   drug adaptation variant [WBPhenotype:0000555] <2>(1|1) (1|0|0)
- 1:   levamisole response variant [WBPhenotype:0000845] <2>(1|1) (1|0|0)
- 1:   nicotine response variant [WBPhenotype:0001573] <2>(10|9) (10|4|1)
- 1:   pore forming toxin response variant [WBPhenotype:0002058] <2>(1|1) (1|0|0)
- 1:   tunicamycin response variant [WBPhenotype:0000359] <2>(0|0) (0|0|0)
- 1:   DMPP response variant [WBPhenotype:0000681] <1>(2|2) (2|1|0)
- 1:   adrenergic receptor antagonist response variant [WBPhenotype:0001337] <1>(2|1) (2|0|0)
- 1:   anticonvulsant response variant [WBPhenotype:0001614] <1>(0|0) (0|0|0)
- 1:   hydroxyurea response variant [WBPhenotype:0001878] <1>(1|1) (2|0|0)
- 1:   inhibitor of serotonin uptake variant [WBPhenotype:0001598] <1>(3|1) (3|0|0)
- 1:   ivermectin response variant [WBPhenotype:0001856] <1>(1|1) (1|2|0)
- 1:   benomyl response variant [WBPhenotype:0001854](0|0) (0|0|0)
- 1:   drug induced life span variant [WBPhenotype:0001871](0|0) (0|0|0)
- 1:   drug induced locomotion variant [WBPhenotype:0001872](0|0) (0|0|0)
- 1:   drug susceptible [WBPhenotype:0002109](0|0) (0|0|0)
- 1:   drug withdrawal response variant [WBPhenotype:0001842](0|1) (0|0|0)
- 1:   ligand gated channel activity variant [WBPhenotype:0001783](0|0) (0|0|0)
- 1:   xenotoxicity suppressor [WBPhenotype:0002384](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Transducin (alpha subunit), insertion domain0Direct
Nicotinic receptor ligand binding domain-like0.00000002132Direct
Neurotransmitter-gated ion-channel transmembrane pore0.00000003454Direct
Ligand-binding domain in the NO signalling and Golgi transport0.000006659Direct
Spectrin repeat0.0002514Direct
Troponin coil-coiled subunits0.0004326Direct
Immunoglobulin0.001326Inherited
PDZ domain-like0.003208Inherited
PYP-like sensor domain (PAS domain)0.005498Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.006013Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.006921Inherited
WD40 repeat-like0.007136Inherited
SAM/Pointed domain0.008434Inherited
ENTH/VHS domain0.008513Inherited
PRTase-like0.008926Inherited
TPR-like0.00952Inherited
SNF-like0.01537Inherited
P-loop containing nucleoside triphosphate hydrolases0.0338Inherited
SNARE-like0.04408Inherited
Protein kinase-like (PK-like)0.08139Inherited
Tubulin C-terminal domain-like0.08201Inherited
Tubulin nucleotide-binding domain-like0.08201Inherited
Cystine-knot cytokines0.09493Inherited
SH3-domain0.1043Inherited
Voltage-gated potassium channels0.1094Inherited
EF-hand0.1117Inherited
Calcium ATPase, transmembrane domain M0.1163Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.1163Inherited
Calcium ATPase, transduction domain A0.1163Inherited
WW domain0.1306Inherited
cAMP-binding domain-like0.1687Inherited
Cysteine-rich domain0.1834Inherited
Transducin (heterotrimeric G protein), gamma chain0.2057Inherited
t-snare proteins0.2057Inherited
Bromodomain0.2057Inherited
HMG-box0.2057Inherited
Myosin rod fragments0.2057Inherited
PH domain-like0.2108Inherited
Homeodomain-like0.2273Inherited
DBL homology domain (DH-domain)0.2408Inherited
HAD-like0.3193Inherited
Leucine zipper domain0.3365Inherited
Nucleic acid-binding proteins0.8711Inherited
"Winged helix" DNA-binding domain0.8803Inherited
beta-beta-alpha zinc fingers0.9382Inherited
Nucleotide cyclase0.9797Inherited
ABC transporter transmembrane region0.9996Inherited
Family A G protein-coupled receptor-like1Inherited
Periplasmic binding protein-like I1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Transducin (alpha subunit), insertion domain0Direct
Quinoprotein alcohol dehydrogenase-like0Direct
Nicotinic receptor ligand binding domain-like0.0000000481Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0000000481Direct
G proteins0.0002069Direct
H-NOX domain0.0002078Direct
Eps15 homology domain (EH domain)0.0002078Direct
Calcium ATPase, transmembrane domain M0.0002899Direct
Spectrin repeat0.0002899Direct
Transforming growth factor (TGF)-beta0.0009062Direct
Synaptotagmin-like (S variant)0.00094Direct
PDZ domain0.001421Inherited
Phosphoribosyltransferases (PRTases)0.004988Inherited
Clathrin coat assembly domain0.004988Inherited
WD40-repeat0.009702Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.01112Inherited
I set domains0.0184Inherited
SNF-like0.02112Inherited
Protein kinases, catalytic subunit0.04624Inherited
Meta-cation ATPase, catalytic domain P0.04799Inherited
Tubulin, GTPase domain0.07678Inherited
Tubulin, C-terminal domain0.07678Inherited
SH3-domain0.1036Inherited
Pleckstrin-homology domain (PH domain)0.1036Inherited
Calcium ATPase, transduction domain A0.1118Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.1118Inherited
Pyridoxal-dependent decarboxylase0.1223Inherited
cAMP-binding domain0.1624Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.1624Inherited
Homeodomain0.1765Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.1946Inherited
t-snare proteins0.1946Inherited
Bromodomain0.1946Inherited
Transducin (heterotrimeric G protein), gamma chain0.1946Inherited
HMG-box0.1946Inherited
Rhodopsin-like0.2281Inherited
DBL homology domain (DH-domain)0.2326Inherited
Voltage-gated potassium channels0.2415Inherited
Leucine zipper domain0.3268Inherited
PLC-like (P variant)0.4238Inherited
ABC transporter transmembrane region0.9591Inherited
Adenylyl and guanylyl cyclase catalytic domain0.9814Inherited
ABC transporter ATPase domain-like1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Transducin (alpha subunit), insertion domain0Direct
Nicotinic receptor ligand binding domain-like0.00000001703Direct
Neurotransmitter-gated ion-channel transmembrane pore0.00000002762Direct
Ligand-binding domain in the NO signalling and Golgi transport0.000005415Direct
Spectrin repeat0.0002068Direct
Troponin coil-coiled subunits0.0003573Direct
Immunoglobulin0.001106Inherited
PDZ domain-like0.002711Inherited
PYP-like sensor domain (PAS domain)0.004676Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.00512Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.005905Inherited
WD40 repeat-like0.006091Inherited
SAM/Pointed domain0.007227Inherited
ENTH/VHS domain0.007297Inherited
PRTase-like0.00766Inherited
TPR-like0.008179Inherited
SNF-like0.01332Inherited
SMAD/FHA domain0.02794Inherited
P-loop containing nucleoside triphosphate hydrolases0.02973Inherited
SNARE-like0.03894Inherited
Protein kinase-like (PK-like)0.07305Inherited
Tubulin C-terminal domain-like0.07363Inherited
Tubulin nucleotide-binding domain-like0.07363Inherited
Cystine-knot cytokines0.0856Inherited
SH3-domain0.09431Inherited
Voltage-gated potassium channels0.09897Inherited
EF-hand0.1012Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.1054Inherited
Calcium ATPase, transmembrane domain M0.1054Inherited
Calcium ATPase, transduction domain A0.1054Inherited
WW domain0.1187Inherited
cAMP-binding domain-like0.1546Inherited
Cysteine-rich domain0.1685Inherited
HMG-box0.1897Inherited
Bromodomain0.1897Inherited
t-snare proteins0.1897Inherited
Myosin rod fragments0.1897Inherited
Transducin (heterotrimeric G protein), gamma chain0.1897Inherited
PH domain-like0.1945Inherited
Homeodomain-like0.2103Inherited
DBL homology domain (DH-domain)0.2232Inherited
HAD-like0.2999Inherited
Leucine zipper domain0.3167Inherited
Nucleic acid-binding proteins0.8549Inherited
"Winged helix" DNA-binding domain0.8645Inherited
beta-beta-alpha zinc fingers0.9244Inherited
Nucleotide cyclase0.968Inherited
ABC transporter transmembrane region0.9894Inherited
Periplasmic binding protein-like I1Inherited
Family A G protein-coupled receptor-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.00000002762Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.0001031Direct
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.0001485Direct
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.0001485Direct
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.0003768Direct
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.0007304Direct
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.00512Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.02794Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.03129Inherited
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.07363Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.1054Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.1187Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.3167Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.9894Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.001229Inherited
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.02794Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)