•  SEARCH

  • Keyword search
  • Sequence search
• 
  

•  BROWSE

  •   Organisms
  • Taxonomy
  • Statistics
  •   SCOP
  • Hierarchy
  •   Ontologies
  • GO
  • EC
  • Phenotype
• 
  

•  TOOLS

  • Compare genomes
  • Phylogenetic trees
  • Web services
  • Downloads
• 
  

•  ABOUT

  • Description
  • Publications
  • Documentation
• 
  

•  HELP

  • User support
  • Contact us
  • Email list
  • Sitemap

Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

• Disease Ontology (DO) Ontology (DO)
  DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
  
• Human Phenotype (HP) Ontology (HP)
  HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
  
• Mouse Phenotype (MP) Ontology (MP)
  MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
  
• Worm Phenotype (WP) Ontology (WP)
  WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
  
• Yeast Phenotype (YP) Ontology (YP)
  Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
  
• Fly Phenotype (FP) Ontology (FP)
  FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
  
• Fly Anatomy (FA) Ontology (FA)
  FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
  
• Zebrafish Anatomy (ZA) Ontology (ZA)
  ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
  
• Xenopus Anatomy (XA) Ontology (XA)
  XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
  
• Arabidopsis Plant Ontology (AP) Ontology (AP)
  As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
  
• Enzyme Commission (EC) Ontology (EC)
  Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
  
• DrugBank ATC (DB) Ontology (DB)
  In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
  
• UniProtKB KeyWords (KW) Ontology (KW)
  Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
  
• UniProtKB UniPathway (UP) Ontology (UP)
  UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
  

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
  

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
  

Superfamily domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Activating enzymes of the ubiquitin-like proteins	0	DIRECT
Acid phosphatase/Vanadium-dependent haloperoxidase	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
FAD-linked reductases, C-terminal domain	0	DIRECT
DHS-like NAD/FAD-binding domain	0	DIRECT
Metal cation-transporting ATPase, ATP-binding domain N	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
Serpins	0	DIRECT
Six-hairpin glycosidases	0	DIRECT
Nop domain	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
FtsH protease domain-like	0	DIRECT
GAS2 domain-like	0	DIRECT
Polo-box domain	0	DIRECT
eIF4e-like	0	DIRECT
Heme-dependent peroxidases	0	DIRECT
Tudor/PWWP/MBT	0	DIRECT
ARID-like	0	DIRECT
Diaminopimelate epimerase-like	0	DIRECT
Acyl-CoA dehydrogenase NM domain-like	0	DIRECT
Radical SAM enzymes	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
FF domain	0	DIRECT
SNF-like	0	DIRECT
Chromo domain-like	0	DIRECT
Riboflavin synthase domain-like	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
ArfGap/RecO-like zinc finger	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
Phosphoglycerate mutase-like	0	DIRECT
Oxysterol-binding protein-like	0	DIRECT
Isocitrate/Isopropylmalate dehydrogenase-like	0	DIRECT
Tricorn protease domain 2	0	DIRECT
Small-conductance potassium channel	0	DIRECT
Metallo-dependent hydrolases	0	DIRECT
Clc chloride channel	0	DIRECT
Tim10-like	0	DIRECT
Ribosomal protein L1	0	DIRECT
Doublecortin (DC)	0	DIRECT
B-box zinc-binding domain	0	DIRECT
LysM domain	0	DIRECT
Ricin B-like lectins	0	DIRECT
eIF1-like	0	DIRECT
PLC-like phosphodiesterases	0	DIRECT
PUA domain-like	0	DIRECT
HCP-like	0	DIRECT
ClpP/crotonase	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
AN1-like Zinc finger	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Elafin-like	0	DIRECT
Lipocalins	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
Mitochondrial cytochrome c oxidase subunit VIc	0	DIRECT
Ras GEF	0	DIRECT
PGBD-like	0	DIRECT
Translation proteins SH3-like domain	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Mitochondrial carrier	0	DIRECT
PAP/OAS1 substrate-binding domain	0	DIRECT
ISP domain	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Pectin lyase-like	0	DIRECT
RCC1/BLIP-II	0	DIRECT
Invertebrate chitin-binding proteins	0	DIRECT
FAD-binding/transporter-associated domain-like	0	DIRECT
Composite domain of metallo-dependent hydrolases	0	DIRECT
Zinc beta-ribbon	0	DIRECT
VPS9 domain	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
Acyl-CoA N-acyltransferases (Nat)	0	DIRECT
Hect, E3 ligase catalytic domain	0	DIRECT
Nucleotidyltransferase	0	DIRECT
Formate/glycerate dehydrogenase catalytic domain-like	0	DIRECT
SH2 domain	0	DIRECT
BEACH domain	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
Cadherin-like	0	DIRECT
Cupredoxins	0	DIRECT
CBS-domain pair	0	DIRECT
AraD/HMP-PK domain-like	0	DIRECT
KA1-like	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
WW domain	0	DIRECT
Ferredoxin reductase-like, C-terminal NADP-linked domain	0	DIRECT
Ankyrin repeat	0	DIRECT
Alkaline phosphatase-like	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
Kix domain of CBP (creb binding protein)	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
Glycosyl hydrolase domain	0	DIRECT
SpoIIaa-like	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
PreATP-grasp domain	0	DIRECT
Pentein	0	DIRECT
CBD9-like	0	DIRECT
Nucleoporin domain	0	DIRECT
LDH C-terminal domain-like	0	DIRECT
Phospholipase D/nuclease	0	DIRECT
RmlC-like cupins	0	DIRECT
NagB/RpiA/CoA transferase-like	0	DIRECT
Terpenoid cyclases/Protein prenyltransferases	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
lambda repressor-like DNA-binding domains	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
MIR domain	0	DIRECT
WWE domain	0	DIRECT
Acyl-CoA dehydrogenase C-terminal domain-like	0	DIRECT
Bet v1-like	0	DIRECT
Heme-dependent catalase-like	0	DIRECT
Myosin rod fragments	0	DIRECT
PLP-binding barrel	0	DIRECT
Periplasmic binding protein-like II	0	DIRECT
Spermadhesin, CUB domain	0	DIRECT
ALDH-like	0	DIRECT
Putative DNA-binding domain	0	DIRECT
HIT-like	0	DIRECT
Cystatin/monellin	0	DIRECT
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
Rhomboid-like	0	DIRECT
Galactose-binding domain-like	0	DIRECT
SMR domain-like	0	DIRECT
YbiA-like	0	DIRECT
Multidrug resistance efflux transporter EmrE	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
NAD kinase/diacylglycerol kinase-like	0	DIRECT
t-snare proteins	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
The spindle assembly checkpoint protein mad2	0	DIRECT
SIS domain	0	DIRECT
Metallo-hydrolase/oxidoreductase	0	DIRECT
Carbonic anhydrase	0	DIRECT
Nucleotide cyclase	0	DIRECT
HMG-box	0	DIRECT
Ganglioside M2 (gm2) activator	0	DIRECT
Galactose mutarotase-like	0	DIRECT
Acid proteases	0	DIRECT
cAMP-binding domain-like	0	DIRECT
Sema domain	0	DIRECT
Creatinase/prolidase N-terminal domain	0	DIRECT
Fibronectin type III	0	DIRECT
ADC-like	0	DIRECT
Hemopexin-like domain	0	DIRECT
Galactose oxidase, central domain	0	DIRECT
BSD domain-like	0	DIRECT
Lipovitellin-phosvitin complex; beta-sheet shell regions	0	DIRECT
WGR domain-like	0	DIRECT
TIMP-like	0	DIRECT
Actin depolymerizing proteins	0	DIRECT
GAT-like domain	0	DIRECT
DNA clamp	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
HIT/MYND zinc finger-like	0	DIRECT
Calpain large subunit, middle domain (domain III)	0	DIRECT
Nucleotide-binding domain	0	DIRECT
Aquaporin-like	0	DIRECT
ABC transporter transmembrane region	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
PHM/PNGase F	0	DIRECT
C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
LEM domain	0	DIRECT
Bromodomain	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
Alpha-L RNA-binding motif	0	DIRECT
Periplasmic binding protein-like I	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
SMAD MH1 domain	0	DIRECT
NTF2-like	0	DIRECT
PP2C-like	0	DIRECT
Pseudouridine synthase	0	DIRECT
PABC (PABP) domain	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
DNase I-like	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
Ribosomal protein S18	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
Aminomethyltransferase beta-barrel domain	0	DIRECT
Chitinase insertion domain	0	DIRECT
Hairpin loop containing domain-like	0	DIRECT
SMAD/FHA domain	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
Transcription factor IIA (TFIIA), beta-barrel domain	0	DIRECT
Cyclophilin-like	0	DIRECT
Purple acid phosphatase, N-terminal domain	0	DIRECT
TK C-terminal domain-like	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
Rudiment single hybrid motif	0	DIRECT
Caspase-like	0	DIRECT
Subdomain of clathrin and coatomer appendage domain	0	DIRECT
CalX-like	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
SAND domain-like	0	DIRECT
GYF domain	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
RUN domain-like	0	DIRECT
PYP-like sensor domain (PAS domain)	0	DIRECT
Actin-crosslinking proteins	0	DIRECT
PRTase-like	0	DIRECT
Cystine-knot cytokines	0	DIRECT
Sec63 N-terminal domain-like	0	DIRECT
Di-copper centre-containing domain	0	DIRECT
Integrin domains	0	DIRECT
Tubby C-terminal domain-like	0	DIRECT
Glycoside hydrolase/deacetylase	0	DIRECT
Outer arm dynein light chain 1	0	DIRECT
BAR/IMD domain-like	0	DIRECT
Sec7 domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
FAD-linked oxidases, C-terminal domain	0	DIRECT
Immunoglobulin	0	DIRECT
Lysozyme-like	0	DIRECT
Cytochrome c	0	DIRECT
PEP carboxykinase-like	0	DIRECT
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0	DIRECT
Kelch motif	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
SAP domain	0	DIRECT
Ribosomal protein S10	0	DIRECT
Subtilisin-like	0	DIRECT
Clathrin adaptor appendage domain	0	DIRECT
TAZ domain	0	DIRECT
RNI-like	0	DIRECT
Hedgehog/intein (Hint) domain	0	DIRECT
CRAL/TRIO domain	0	DIRECT
Hormone receptor domain	0	DIRECT
Mss4-like	0	DIRECT
BolA-like	0	DIRECT
Calcium ATPase, transduction domain A	0	DIRECT
Adenine nucleotide alpha hydrolases-like	0	DIRECT
PIN domain-like	0	DIRECT
NAD(P)-linked oxidoreductase	0	DIRECT
Second domain of FERM	0	DIRECT
EF-G C-terminal domain-like	0	DIRECT
PEBP-like	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
SET domain	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
Ferritin-like	0	DIRECT
Protease propeptides/inhibitors	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
RuvA domain 2-like	0	DIRECT
Carboxypeptidase regulatory domain-like	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
ADP-ribosylation	0	DIRECT
Ribokinase-like	0	DIRECT
Rhodanese/Cell cycle control phosphatase	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
Nudix	0	DIRECT
Calcium-dependent phosphotriesterase	0	DIRECT
Spectrin repeat	0	DIRECT
PAZ domain	0	DIRECT
Ypt/Rab-GAP domain of gyp1p	0	DIRECT
PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	DIRECT
dsRNA-binding domain-like	0	DIRECT
Cytochrome b5-like heme/steroid binding domain	0	DIRECT
Phoshotransferase/anion transport protein	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
NHL repeat	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
Tautomerase/MIF	0	DIRECT
Troponin coil-coiled subunits	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
SCP-like	0	DIRECT
L30e-like	0	DIRECT
Plexin repeat	0	DIRECT
Arginase/deacetylase	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
SAICAR synthase-like	0	DIRECT
SPOC domain-like	0	DIRECT
Osmotin, thaumatin-like protein	0	DIRECT
Flavoproteins	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
R3H domain	0	DIRECT
SGNH hydrolase	0	DIRECT
Mob1/phocein	0	DIRECT
Metallo-dependent phosphatases	0	DIRECT
2Fe-2S ferredoxin-like	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
p53-like transcription factors	0	DIRECT
Aldolase	0	DIRECT
PR-1-like	0	DIRECT
alpha-helical ferredoxin	0	DIRECT
Lipovitellin-phosvitin complex, superhelical domain	0	DIRECT
Transcription factor IIA (TFIIA), alpha-helical domain	0	DIRECT
Aminoacid dehydrogenase-like, N-terminal domain	0	DIRECT
Cytidine deaminase-like	0	DIRECT
Cysteine-rich domain	0	DIRECT
Intermediate filament protein, coiled coil region	0	DIRECT
BPTI-like	0	DIRECT
Rap/Ran-GAP	0	DIRECT
Glutamine synthetase/guanido kinase	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
Complement control module/SCR domain	0	DIRECT
Phospholipase A2, PLA2	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
Molybdenum cofactor biosynthesis proteins	0	DIRECT
HRDC-like	0	DIRECT
HD-domain/PDEase-like	0	DIRECT
Apyrase	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
MFPT repeat-like	0	DIRECT
alpha-catenin/vinculin-like	0	DIRECT
E2F-DP heterodimerization region	0	DIRECT
Families 57/38 glycoside transferase middle domain	0	DIRECT
LuxS/MPP-like metallohydrolase	0	DIRECT
BRCT domain	0	DIRECT
Glycerol-3-phosphate (1)-acyltransferase	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
MIT domain	0	DIRECT
PK beta-barrel domain-like	0	DIRECT
Kringle-like	0	DIRECT
Annexin	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
Calcium ATPase, transmembrane domain M	0	DIRECT
PX domain	0	DIRECT
alpha/beta knot	0	DIRECT
Restriction endonuclease-like	0	DIRECT
Ammonium transporter	0	DIRECT
DEATH domain	0	DIRECT
MgtE membrane domain-like	0	DIRECT
Carbon-nitrogen hydrolase	0	DIRECT
beta-lactamase/transpeptidase-like	0	DIRECT
Carbohydrate phosphatase	0	DIRECT
PLP-dependent transferases	0	DIRECT
Folate-binding domain	0	DIRECT
Metalloproteases ("zincins"), catalytic domain	0	DIRECT
Translational machinery components	0	DIRECT
Ribulose-phoshate binding barrel	0	DIRECT
GHMP Kinase, C-terminal domain	0	DIRECT
Integrin alpha N-terminal domain	0	DIRECT
Thioesterase/thiol ester dehydrase-isomerase	0	DIRECT
Serine protease inhibitors	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
L-aspartase-like	0	DIRECT
Phosphoenolpyruvate/pyruvate domain	0	DIRECT
Cation efflux protein transmembrane domain-like	0	DIRECT
Purine and uridine phosphorylases	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT

Family domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
La domain	0	DIRECT
D-aminoacid oxidase-like	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Annexin	0	DIRECT
Cytoplasmic domain of inward rectifier potassium channel	0	DIRECT
Oxysterol-binding protein	0	DIRECT
alpha-Amylases, C-terminal beta-sheet domain	0	DIRECT
Ribosomal protein S10	0	DIRECT
PAZ domain	0	DIRECT
Poly(A) polymerase, PAP, C-terminal domain	0	DIRECT
MPP-like	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Pleckstrin-homology domain (PH domain)	0	DIRECT
NOL1/NOP2/sun	0	DIRECT
Ferredoxin reductase FAD-binding domain-like	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
DEATH domain, DD	0	DIRECT
28-residue LRR	0	DIRECT
ALDH-like	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
YihX-like	0	DIRECT
Phoshoinositide 3-kinase (PI3K) helical domain	0	DIRECT
Tudor domain	0	DIRECT
Pyk2-associated protein beta ARF-GAP domain	0	DIRECT
beta 1,4 galactosyltransferase (b4GalT1)	0	DIRECT
Ankyrin repeat	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
Cytidylyltransferase	0	DIRECT
FAD/NAD-linked reductases, N-terminal and central domains	0	DIRECT
HEAT repeat	0	DIRECT
Hermes transposase-like	0	DIRECT
Patatin	0	DIRECT
POU-specific domain	0	DIRECT
SAND domain	0	DIRECT
E2F dimerization segment	0	DIRECT
BC N-terminal domain-like	0	DIRECT
Matrix metalloproteases, catalytic domain	0	DIRECT
Rhomboid-like	0	DIRECT
Aldo-keto reductases (NADP)	0	DIRECT
Sterol carrier protein, SCP	0	DIRECT
Calpain large subunit, middle domain (domain III)	0	DIRECT
Cation efflux protein transmembrane domain-like	0	DIRECT
GAPDH-like	0	DIRECT
Class I alpha-1;2-mannosidase, catalytic domain	0	DIRECT
Hedgehog C-terminal (Hog) autoprocessing domain	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
Integrin domains	0	DIRECT
RNA methyltransferase FtsJ	0	DIRECT
Catalytic, N-terminal domain of histone methyltransferase Dot1l	0	DIRECT
Plexin repeat	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Anticodon-binding domain	0	DIRECT
GABA-aminotransferase-like	0	DIRECT
Lipovitellin-phosvitin complex, superhelical domain	0	DIRECT
Tetraspanin	0	DIRECT
Gamma-glutamyltranspeptidase-like	0	DIRECT
Ganglioside M2 (gm2) activator	0	DIRECT
Laminin G-like module	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
Cadherin	0	DIRECT
Mo25 protein	0	DIRECT
Ypt/Rab-GAP domain of gyp1p	0	DIRECT
LIM domain	0	DIRECT
Trehalase-like	0	DIRECT
Gastric lipase	0	DIRECT
Ribosomal protein L18 and S11	0	DIRECT
BAR domain	0	DIRECT
XPF/Rad1/Mus81 nuclease	0	DIRECT
alpha-catenin/vinculin	0	DIRECT
alpha-mannosidase	0	DIRECT
SH2 domain	0	DIRECT
Reductases	0	DIRECT
Laminin-type module	0	DIRECT
Mitochondrial carrier	0	DIRECT
GAS2 domain	0	DIRECT
NLI interacting factor-like phosphatase	0	DIRECT
Class I aldolase	0	DIRECT
Neurotransmitter-gated ion-channel transmembrane pore	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
PDI-like	0	DIRECT
FAD-linked reductases, N-terminal domain	0	DIRECT
Choline/Carnitine O-acyltransferase	0	DIRECT
Aquaporin-like	0	DIRECT
Kix domain of CBP (creb binding protein)	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
Clathrin coat assembly domain	0	DIRECT
RIO1-like kinases	0	DIRECT
RNA editing terminal uridyl transferase 2, RET2, domain 2	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Glycogenin	0	DIRECT
ZZ domain	0	DIRECT
beta-CASP RNA-metabolising hydrolases	0	DIRECT
Poly(A) polymerase, PAP, middle domain	0	DIRECT
MutT-like	0	DIRECT
Hemocyanin middle domain	0	DIRECT
NADPH-cytochrome p450 reductase-like	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
Proprotein convertase P-domain	0	DIRECT
4HBT-like	0	DIRECT
Calcium ATPase, transduction domain A	0	DIRECT
Ribonuclease H	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
Polypeptide N-acetylgalactosaminyltransferase 1, N-terminal domain	0	DIRECT
PR-1-like	0	DIRECT
WWE domain	0	DIRECT
CoA-binding domain	0	DIRECT
Chromo domain	0	DIRECT
acyl-CoA oxidase C-terminal domains	0	DIRECT
Poly(ADP-ribose) polymerase, C-terminal domain	0	DIRECT
Epoxide hydrolase	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
PDEase	0	DIRECT
Phosphoribosyltransferases (PRTases)	0	DIRECT
Peptidylglycine alpha-hydroxylating monooxygenase, PHM	0	DIRECT
NTF2-like	0	DIRECT
Pancreatic carboxypeptidases	0	DIRECT
MIT domain	0	DIRECT
Cofilin-like	0	DIRECT
PX domain	0	DIRECT
N-acetylglucosaminyltransferase I	0	DIRECT
Linker histone H1/H5	0	DIRECT
ATI-like	0	DIRECT
Aminoacid dehydrogenase-like, C-terminal domain	0	DIRECT
Crotonase-like	0	DIRECT
Carboxylesterase	0	DIRECT
Synaptotagmin-like (S variant)	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
HCDH C-domain-like	0	DIRECT
Spectrin repeat	0	DIRECT
Kinase associated domain 1, KA1	0	DIRECT
beta-glycanases	0	DIRECT
Rap/Ran-GAP	0	DIRECT
Metal cation-transporting ATPase, ATP-binding domain N	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Myeloperoxidase-like	0	DIRECT
Lipovitellin-phosvitin complex; beta-sheet shell regions	0	DIRECT
Hsp90 middle domain	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	0	DIRECT
LEM domain	0	DIRECT
Inositol polyphosphate kinase (IPK)	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
NHL repeat	0	DIRECT
Sir2 family of transcriptional regulators	0	DIRECT
BC ATP-binding domain-like	0	DIRECT
cAMP-binding domain	0	DIRECT
CBS-domain pair	0	DIRECT
2Fe-2S ferredoxin domains from multidomain proteins	0	DIRECT
Transcriptional factor domain	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
Guanido kinase catalytic domain	0	DIRECT
Serpins	0	DIRECT
Filamin repeat (rod domain)	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
Hydantoinase (dihydropyrimidinase)	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
MIF-related	0	DIRECT
Subtilases	0	DIRECT
YicI catalytic domain-like	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
Formate/glycerate dehydrogenases, NAD-domain	0	DIRECT
ARID domain	0	DIRECT
L30e/L7ae ribosomal proteins	0	DIRECT
CO dehydrogenase flavoprotein N-terminal domain-like	0	DIRECT
Methionine aminopeptidase, insert domain	0	DIRECT
Regulator of chromosome condensation RCC1	0	DIRECT
N-acetyl transferase, NAT	0	DIRECT
Hydantoinase (dihydropyrimidinase), catalytic domain	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
Cdc48 N-terminal domain-like	0	DIRECT
Second domain of FERM	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
UDP-glucose pyrophosphorylase	0	DIRECT
Multidomain sulfurtransferase (rhodanese)	0	DIRECT
Classic zinc finger, C2H2	0	DIRECT
TatD Mg-dependent DNase-like	0	DIRECT
Bacterial dinuclear zinc exopeptidases	0	DIRECT
IF2B-like	0	DIRECT
H-NOX domain	0	DIRECT
AraD-like aldolase/epimerase	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
Ribosomal protein S18	0	DIRECT
Small-conductance potassium channel	0	DIRECT
MIR domain	0	DIRECT
HAT/Suf repeat	0	DIRECT
YbiA-like	0	DIRECT
Ras-binding domain, RBD	0	DIRECT
Purine and uridine phosphorylases	0	DIRECT
Sema domain	0	DIRECT
Polo-box duplicated region	0	DIRECT
Acireductone dioxygenase	0	DIRECT
HD domain	0	DIRECT
Purple acid phosphatase, N-terminal domain	0	DIRECT
TAZ domain	0	DIRECT
PLC-like (P variant)	0	DIRECT
Glycerophosphoryl diester phosphodiesterase	0	DIRECT
5' to 3' exonuclease catalytic domain	0	DIRECT
Carboxypeptidase regulatory domain	0	DIRECT
Sec63 C-terminal domain-like	0	DIRECT
Gelsolin-like	0	DIRECT
AlkB-like	0	DIRECT
Lactate & malate dehydrogenases, C-terminal domain	0	DIRECT
Fungal lipases	0	DIRECT
Elafin-like	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
Phoshatidylinositol transfer protein, PITP	0	DIRECT
EF-hand modules in multidomain proteins	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Double-stranded RNA-binding domain (dsRBD)	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
Sm motif of small nuclear ribonucleoproteins, SNRNP	0	DIRECT
1,3-glucuronyltransferase	0	DIRECT
Autophagin-like	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
FtsH protease domain-like	0	DIRECT
Transcription factor IIA (TFIIA), beta-barrel domain	0	DIRECT
CRAL/TRIO domain	0	DIRECT
Sec7 domain	0	DIRECT
L-aminoacid/polyamine oxidase	0	DIRECT
Tim10/DDP	0	DIRECT
Cystathionine synthase-like	0	DIRECT
Type II chitinase	0	DIRECT
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain	0	DIRECT
Cell cycle control phosphatase, catalytic domain	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
MIF4G domain-like	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Inositol polyphosphate 5-phosphatase (IPP5)	0	DIRECT
Histone deacetylase, HDAC	0	DIRECT
Inositol monophosphatase/fructose-1,6-bisphosphatase-like	0	DIRECT
Glutaminase	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
Carbonic anhydrase	0	DIRECT
Pseudouridine synthase I TruA	0	DIRECT
Mammalian PLC	0	DIRECT
Serine carboxypeptidase-like	0	DIRECT
Choline kinase	0	DIRECT
Protein prenyltransferases	0	DIRECT
LacY-like proton/sugar symporter	0	DIRECT
EF-G/eEF-2 domains III and V	0	DIRECT
BC C-terminal domain-like	0	DIRECT
Ras GEF	0	DIRECT
Glycerol-3-phosphate transporter	0	DIRECT
SMAD domain	0	DIRECT
Serum paraoxonase/arylesterase 1, PON1	0	DIRECT
Third domain of FERM	0	DIRECT
PaaI/YdiI-like	0	DIRECT
Purple acid phosphatase-like	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
Bactericidal permeability-increasing protein, BPI	0	DIRECT
T-box	0	DIRECT
WGR domain	0	DIRECT
CoA transferase alpha subunit-like	0	DIRECT
ABC transporter transmembrane region	0	DIRECT
Phoshoinositide 3-kinase (PI3K), catalytic domain	0	DIRECT
eIF1-like	0	DIRECT
AMPK-beta glycogen binding domain-like	0	DIRECT
alpha-mannosidase, C-terminal domain	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
Cyclophilin (peptidylprolyl isomerase)	0	DIRECT
B-box zinc-binding domain	0	DIRECT
Translation initiation factor eIF4e	0	DIRECT
L-arabinose binding protein-like	0	DIRECT
Class II glutamine amidotransferases	0	DIRECT
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
Elongation factors	0	DIRECT
Adenosine/AMP deaminase	0	DIRECT
LDH N-terminal domain-like	0	DIRECT
Myosin rod fragments	0	DIRECT
Ubiquitin activating enzymes (UBA)	0	DIRECT
Histidine acid phosphatase	0	DIRECT
Dimeric isocitrate & isopropylmalate dehydrogenases	0	DIRECT
Clc chloride channel	0	DIRECT
Integrin A (or I) domain	0	DIRECT
Leukotriene A4 hydrolase catalytic domain	0	DIRECT
Calcium ATPase, transmembrane domain M	0	DIRECT
Mob1/phocein	0	DIRECT
Band 7/SPFH domain	0	DIRECT
Fibronectin type III	0	DIRECT
AN1-like Zinc finger	0	DIRECT
Sec63 N-terminal domain	0	DIRECT
Arfaptin, Rac-binding fragment	0	DIRECT
Proteasome subunits	0	DIRECT
U-box	0	DIRECT
D-aminoacid oxidase, N-terminal domain	0	DIRECT
Transforming growth factor (TGF)-beta	0	DIRECT
UDPGT-like	0	DIRECT
Ephrin ectodomain	0	DIRECT
GYF domain	0	DIRECT
Zf-UBP	0	DIRECT
Bacterial lipase	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
RhoGDI-like	0	DIRECT
t-snare proteins	0	DIRECT
Heme-dependent catalases	0	DIRECT
MFPT repeat	0	DIRECT
FF domain	0	DIRECT
Myotubularin-like phosphatases	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
BEACH domain	0	DIRECT
Internalin LRR domain	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
Poly(A) polymerase, PAP, N-terminal domain	0	DIRECT
Astacin	0	DIRECT
PABC (PABP) domain	0	DIRECT
I set domains	0	DIRECT
Phosphate binding protein-like	0	DIRECT
Biotin dependent carboxylase carboxyltransferase domain	0	DIRECT
Aminomethyltransferase beta-barrel domain	0	DIRECT
Erythroid transcription factor GATA-1	0	DIRECT
Arylsulfatase	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
STAR domain	0	DIRECT
Galectin (animal S-lectin)	0	DIRECT
GHMP Kinase, N-terminal domain	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
Reprolysin-like	0	DIRECT
NagD-like	0	DIRECT
UBX domain	0	DIRECT
SNF-like	0	DIRECT
Pepsin-like	0	DIRECT
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta	0	DIRECT
Glutamine synthetase catalytic domain	0	DIRECT
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains	0	DIRECT
Smr domain	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
Acyl-CoA thioesterase	0	DIRECT
UBA domain	0	DIRECT
Bromodomain	0	DIRECT
Translational machinery components	0	DIRECT
Phosphotyrosine-binding domain (PTB)	0	DIRECT
Cytochrome b5	0	DIRECT
Small Kunitz-type inhibitors & BPTI-like toxins	0	DIRECT
COMT-like	0	DIRECT
Phosphatidylethanolamine binding protein	0	DIRECT
PP2C-like	0	DIRECT
Adenain-like	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
Osmotin, thaumatin-like protein	0	DIRECT
Family 19 glycosidase	0	DIRECT
Doublecortin (DC)	0	DIRECT
RNA-polymerase beta-prime	0	DIRECT
Fatty acid binding protein-like	0	DIRECT
Hexokinase	0	DIRECT
acyl-CoA oxidase N-terminal domains	0	DIRECT
p120GAP domain-like	0	DIRECT
SAP domain	0	DIRECT
FHA domain	0	DIRECT
RUN domain	0	DIRECT
Ngr ectodomain-like	0	DIRECT
Ribonuclease PH domain 1-like	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
RNA-polymerase beta	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
PhyH-like	0	DIRECT
Rv2717c-like	0	DIRECT
First domain of FERM	0	DIRECT
Acetylcholinesterase-like	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain	0	DIRECT
Ribokinase-like	0	DIRECT
BSD domain	0	DIRECT
beta-Lactamase/D-ala carboxypeptidase	0	DIRECT
HMG-box	0	DIRECT
CalX-beta domain	0	DIRECT
Deoxycytidylate deaminase-like	0	DIRECT
DPP6 catalytic domain-like	0	DIRECT
AAT-like	0	DIRECT
Caspase catalytic domain	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
Intermediate filament protein, coiled coil region	0	DIRECT
Acylamino-acid-releasing enzyme, C-terminal donain	0	DIRECT
alpha-mannosidase, domain 2	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
Ricin B-like	0	DIRECT
Glycerol kinase	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
WW domain	0	DIRECT
PUA domain	0	DIRECT
SWIRM domain	0	DIRECT
Meta-cation ATPase, catalytic domain P	0	DIRECT
RecA protein-like (ATPase-domain)	0	DIRECT
Nop domain	0	DIRECT
Amylase, catalytic domain	0	DIRECT
Protein serine/threonine phosphatase	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
Hormone receptor domain	0	DIRECT
Extended PAW domain	0	DIRECT
Hemopexin-like domain	0	DIRECT
Spermadhesin, CUB domain	0	DIRECT
Calpain large subunit, catalytic domain (domain II)	0	DIRECT
N-type ATP pyrophosphatases	0	DIRECT
HSP20	0	DIRECT
Pyridoxal-dependent decarboxylase	0	DIRECT
BolA-like	0	DIRECT
Higher-molecular-weight phosphotyrosine protein phosphatases	0	DIRECT
CUT domain	0	DIRECT
PEP carboxykinase C-terminal domain	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Histone lysine methyltransferases	0	DIRECT
Transcription factor IIA (TFIIA), alpha-helical domain	0	DIRECT
Clathrin adaptor core protein	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
TBP-associated factors, TAFs	0	DIRECT
PhzC/PhzF-like	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
Neurolysin-like	0	DIRECT
Ribosomal protein L1	0	DIRECT
Complement control module/SCR domain	0	DIRECT
F-box domain	0	DIRECT
Ribonucleotide reductase-like	0	DIRECT
Kelch motif	0	DIRECT
LysM domain	0	DIRECT
Dual specificity phosphatase-like	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
Troponin I	0	DIRECT
Lesion bypass DNA polymerase (Y-family), catalytic domain	0	DIRECT
Hect, E3 ligase catalytic domain	0	DIRECT
Cell cycle transcription factor e2f-dp	0	DIRECT
Pancreatic carboxypeptidase, activation domain	0	DIRECT
ATP-dependent protease Lon (La), catalytic domain	0	DIRECT
Neutral endopeptidase (neprilysin)	0	DIRECT
Chitinase insertion domain	0	DIRECT
Tetramerization domain of potassium channels	0	DIRECT
Eps15 homology domain (EH domain)	0	DIRECT
Apyrase	0	DIRECT
L domain	0	DIRECT
ets domain	0	DIRECT
NADPH-cytochrome p450 reductase FAD-binding domain-like	0	DIRECT
Papain-like	0	DIRECT
FCH domain	0	DIRECT
Arginine methyltransferase	0	DIRECT
Aminomethyltransferase folate-binding domain	0	DIRECT
SMAD MH1 domain	0	DIRECT
SAM (sterile alpha motif) domain	0	DIRECT
Adenylyl and guanylyl cyclase catalytic domain	0	DIRECT
Arylamine N-methyltransferase	0	DIRECT
Ammonium transporter	0	DIRECT