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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

• Disease Ontology (DO) Ontology (DO)
  DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
  
• Human Phenotype (HP) Ontology (HP)
  HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
  
• Mouse Phenotype (MP) Ontology (MP)
  MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
  
• Worm Phenotype (WP) Ontology (WP)
  WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
  
• Yeast Phenotype (YP) Ontology (YP)
  Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
  
• Fly Phenotype (FP) Ontology (FP)
  FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
  
• Fly Anatomy (FA) Ontology (FA)
  FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
  
• Zebrafish Anatomy (ZA) Ontology (ZA)
  ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
  
• Xenopus Anatomy (XA) Ontology (XA)
  XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
  
• Arabidopsis Plant Ontology (AP) Ontology (AP)
  As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
  
• Enzyme Commission (EC) Ontology (EC)
  Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
  
• DrugBank ATC (DB) Ontology (DB)
  In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
  
• UniProtKB KeyWords (KW) Ontology (KW)
  Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
  
• UniProtKB UniPathway (UP) Ontology (UP)
  UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
  

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
  

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
  

Superfamily domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
EB1 dimerisation domain-like	0	DIRECT
CalX-like	0	DIRECT
LDH C-terminal domain-like	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
Clathrin adaptor appendage domain	0	DIRECT
Lipovitellin-phosvitin complex, superhelical domain	0	DIRECT
Aminoacid dehydrogenase-like, N-terminal domain	0	DIRECT
Calpain large subunit, middle domain (domain III)	0	DIRECT
Mss4-like	0	DIRECT
CoA-dependent acyltransferases	0	DIRECT
Restriction endonuclease-like	0	DIRECT
Sema domain	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
Phosphoglycerate mutase-like	0	DIRECT
PEP carboxykinase-like	0	DIRECT
alpha-helical ferredoxin	0	DIRECT
p53-like transcription factors	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Hedgehog/intein (Hint) domain	0	DIRECT
Ribokinase-like	0	DIRECT
Carbon-nitrogen hydrolase	0	DIRECT
Intermediate filament protein, coiled coil region	0	DIRECT
Cyclophilin-like	0	DIRECT
Carbonic anhydrase	0	DIRECT
Ferritin-like	0	DIRECT
TK C-terminal domain-like	0	DIRECT
Periplasmic binding protein-like II	0	DIRECT
eIF4e-like	0	DIRECT
B-box zinc-binding domain	0	DIRECT
PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	DIRECT
SMAD/FHA domain	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
RUN domain-like	0	DIRECT
Aquaporin-like	0	DIRECT
Chromo domain-like	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
PIN domain-like	0	DIRECT
ADP-ribosylation	0	DIRECT
NTF2-like	0	DIRECT
Glycosyl hydrolase domain	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
Ypt/Rab-GAP domain of gyp1p	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
Hemopexin-like domain	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
Ras GEF	0	DIRECT
Doublecortin (DC)	0	DIRECT
Ribosomal protein L1	0	DIRECT
PYP-like sensor domain (PAS domain)	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0	DIRECT
PK beta-barrel domain-like	0	DIRECT
ISP domain	0	DIRECT
BPTI-like	0	DIRECT
Nucleotide-binding domain	0	DIRECT
alpha/beta knot	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
LysM domain	0	DIRECT
BolA-like	0	DIRECT
NHL repeat	0	DIRECT
CBS-domain pair	0	DIRECT
PAP/OAS1 substrate-binding domain	0	DIRECT
Serine protease inhibitors	0	DIRECT
Rudiment single hybrid motif	0	DIRECT
Thioesterase/thiol ester dehydrase-isomerase	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
2Fe-2S ferredoxin-like	0	DIRECT
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0	DIRECT
Multidrug resistance efflux transporter EmrE	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
BEACH domain	0	DIRECT
Phospholipase A2, PLA2	0	DIRECT
Tautomerase/MIF	0	DIRECT
PHM/PNGase F	0	DIRECT
Subtilisin-like	0	DIRECT
HD-domain/PDEase-like	0	DIRECT
PR-1-like	0	DIRECT
Calcium-dependent phosphotriesterase	0	DIRECT
NagB/RpiA/CoA transferase-like	0	DIRECT
GYF domain	0	DIRECT
MFPT repeat-like	0	DIRECT
Nudix	0	DIRECT
Molybdenum cofactor biosynthesis proteins	0	DIRECT
MIR domain	0	DIRECT
Subdomain of clathrin and coatomer appendage domain	0	DIRECT
TGS-like	0	DIRECT
Alkaline phosphatase-like	0	DIRECT
Ricin B-like lectins	0	DIRECT
beta-lactamase/transpeptidase-like	0	DIRECT
Ferredoxin reductase-like, C-terminal NADP-linked domain	0	DIRECT
Formate/glycerate dehydrogenase catalytic domain-like	0	DIRECT
EF-G C-terminal domain-like	0	DIRECT
Acid proteases	0	DIRECT
Integrin alpha N-terminal domain	0	DIRECT
Myosin rod fragments	0	DIRECT
Outer arm dynein light chain 1	0	DIRECT
Integrin domains	0	DIRECT
FF domain	0	DIRECT
AraD/HMP-PK domain-like	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
SMAD MH1 domain	0	DIRECT
SAND domain-like	0	DIRECT
Activating enzymes of the ubiquitin-like proteins	0	DIRECT
L-aspartase-like	0	DIRECT
SET domain	0	DIRECT
LEM domain	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
Pectin lyase-like	0	DIRECT
DNase I-like	0	DIRECT
Folate-binding domain	0	DIRECT
Adenine nucleotide alpha hydrolases-like	0	DIRECT
Spermadhesin, CUB domain	0	DIRECT
Mob1/phocein	0	DIRECT
DHS-like NAD/FAD-binding domain	0	DIRECT
Immunoglobulin	0	DIRECT
Cystatin/monellin	0	DIRECT
Nucleotidyltransferase	0	DIRECT
eIF1-like	0	DIRECT
Acyl-CoA N-acyltransferases (Nat)	0	DIRECT
Kelch motif	0	DIRECT
Cysteine-rich domain	0	DIRECT
Hormone receptor domain	0	DIRECT
Annexin	0	DIRECT
SAICAR synthase-like	0	DIRECT
Cupredoxins	0	DIRECT
t-snare proteins	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
GHMP Kinase, C-terminal domain	0	DIRECT
Bromodomain	0	DIRECT
Phosphoenolpyruvate/pyruvate domain	0	DIRECT
PreATP-grasp domain	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
Tudor/PWWP/MBT	0	DIRECT
Riboflavin synthase domain-like	0	DIRECT
Terpenoid cyclases/Protein prenyltransferases	0	DIRECT
Metallo-dependent hydrolases	0	DIRECT
Zinc beta-ribbon	0	DIRECT
Aminomethyltransferase beta-barrel domain	0	DIRECT
Calcium ATPase, transmembrane domain M	0	DIRECT
Isocitrate/Isopropylmalate dehydrogenase-like	0	DIRECT
Rhomboid-like	0	DIRECT
Nucleotide cyclase	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
Di-copper centre-containing domain	0	DIRECT
Pseudouridine synthase	0	DIRECT
PP2C-like	0	DIRECT
Glutamine synthetase/guanido kinase	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
WWE domain	0	DIRECT
Carbohydrate phosphatase	0	DIRECT
Lipovitellin-phosvitin complex; beta-sheet shell regions	0	DIRECT
Tricorn protease domain 2	0	DIRECT
L30e-like	0	DIRECT
Polo-box domain	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
Creatinase/prolidase N-terminal domain	0	DIRECT
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
WW domain	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
Tubby C-terminal domain-like	0	DIRECT
Cytochrome b5-like heme/steroid binding domain	0	DIRECT
Oxysterol-binding protein-like	0	DIRECT
cAMP-binding domain-like	0	DIRECT
Cadherin-like	0	DIRECT
Invertebrate chitin-binding proteins	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
The spindle assembly checkpoint protein mad2	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
RmlC-like cupins	0	DIRECT
BRCT domain	0	DIRECT
GAS2 domain-like	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
MIT domain	0	DIRECT
Hairpin loop containing domain-like	0	DIRECT
Troponin coil-coiled subunits	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
Cystine-knot cytokines	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
Elafin-like	0	DIRECT
SCP-like	0	DIRECT
Galactose mutarotase-like	0	DIRECT
Actin depolymerizing proteins	0	DIRECT
alpha-catenin/vinculin-like	0	DIRECT
Sec7 domain	0	DIRECT
Ganglioside M2 (gm2) activator	0	DIRECT
Actin-crosslinking proteins	0	DIRECT
Single hybrid motif	0	DIRECT
SAP domain	0	DIRECT
Rhodanese/Cell cycle control phosphatase	0	DIRECT
MgtE membrane domain-like	0	DIRECT
Heme-dependent catalase-like	0	DIRECT
YbiA-like	0	DIRECT
Phoshotransferase/anion transport protein	0	DIRECT
Translation proteins SH3-like domain	0	DIRECT
Calcium ATPase, transduction domain A	0	DIRECT
NAD(P)-linked oxidoreductase	0	DIRECT
dsRNA-binding domain-like	0	DIRECT
PX domain	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
Purine and uridine phosphorylases	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
HMG-box	0	DIRECT
Alpha-L RNA-binding motif	0	DIRECT
CBD9-like	0	DIRECT
ADC-like	0	DIRECT
HIT-like	0	DIRECT
Apyrase	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
BAR/IMD domain-like	0	DIRECT
Spectrin repeat	0	DIRECT
HCP-like	0	DIRECT
Metal cation-transporting ATPase, ATP-binding domain N	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
CRAL/TRIO domain	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
E2F-DP heterodimerization region	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
FAD-linked oxidases, C-terminal domain	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
Radical SAM enzymes	0	DIRECT
Families 57/38 glycoside transferase middle domain	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
FtsH protease domain-like	0	DIRECT
KA1-like	0	DIRECT
Second domain of FERM	0	DIRECT
HIT/MYND zinc finger-like	0	DIRECT
Acid phosphatase/Vanadium-dependent haloperoxidase	0	DIRECT
Caspase-like	0	DIRECT
Metalloproteases ("zincins"), catalytic domain	0	DIRECT
Cytochrome c	0	DIRECT
RuvA domain 2-like	0	DIRECT
Rap/Ran-GAP	0	DIRECT
VPS9 domain	0	DIRECT
Fibronectin type III	0	DIRECT
HRDC-like	0	DIRECT
Cation efflux protein transmembrane domain-like	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Periplasmic binding protein-like I	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
NAD kinase/diacylglycerol kinase-like	0	DIRECT
ThrRS/AlaRS common domain	0	DIRECT
Arginase/deacetylase	0	DIRECT
SPOC domain-like	0	DIRECT
SIS domain	0	DIRECT
PRTase-like	0	DIRECT
RCC1/BLIP-II	0	DIRECT
lambda repressor-like DNA-binding domains	0	DIRECT
Ammonium transporter	0	DIRECT
Sec63 N-terminal domain-like	0	DIRECT
Lipocalins	0	DIRECT
Nop domain	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
PUA domain-like	0	DIRECT
SGNH hydrolase	0	DIRECT
DEATH domain	0	DIRECT
Putative DNA-binding domain	0	DIRECT
Plexin repeat	0	DIRECT
Acyl-CoA dehydrogenase C-terminal domain-like	0	DIRECT
Purple acid phosphatase, N-terminal domain	0	DIRECT
PLP-dependent transferases	0	DIRECT
Heme-dependent peroxidases	0	DIRECT
Kix domain of CBP (creb binding protein)	0	DIRECT
DNA clamp	0	DIRECT
PLC-like phosphodiesterases	0	DIRECT
Flavoproteins	0	DIRECT
Acyl-CoA dehydrogenase NM domain-like	0	DIRECT
Bet v1-like	0	DIRECT
Osmotin, thaumatin-like protein	0	DIRECT
Galactose-binding domain-like	0	DIRECT
Clc chloride channel	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Mitochondrial cytochrome c oxidase subunit VIc	0	DIRECT
Six-hairpin glycosidases	0	DIRECT
Ribulose-phoshate binding barrel	0	DIRECT
Composite domain of metallo-dependent hydrolases	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
FAD-binding/transporter-associated domain-like	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
Nucleoporin domain	0	DIRECT
WGR domain-like	0	DIRECT
Kringle-like	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
Lysozyme-like	0	DIRECT
LexA/Signal peptidase	0	DIRECT
ARID-like	0	DIRECT
Glycerol-3-phosphate (1)-acyltransferase	0	DIRECT
SMR domain-like	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
Cytidine deaminase-like	0	DIRECT
ClpP/crotonase	0	DIRECT
AN1-like Zinc finger	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
Complement control module/SCR domain	0	DIRECT
RNI-like	0	DIRECT
Protease propeptides/inhibitors	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
GAT-like domain	0	DIRECT
ArfGap/RecO-like zinc finger	0	DIRECT
Diaminopimelate epimerase-like	0	DIRECT
SpoIIaa-like	0	DIRECT
Translational machinery components	0	DIRECT
ALDH-like	0	DIRECT
FAD-linked reductases, C-terminal domain	0	DIRECT
Metallo-dependent phosphatases	0	DIRECT
Ankyrin repeat	0	DIRECT
Aldolase	0	DIRECT
Hect, E3 ligase catalytic domain	0	DIRECT
Carboxypeptidase regulatory domain-like	0	DIRECT
Glycoside hydrolase/deacetylase	0	DIRECT
Mitochondrial carrier	0	DIRECT
TIMP-like	0	DIRECT
R3H domain	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
Metallo-hydrolase/oxidoreductase	0	DIRECT
Translation proteins	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
Serpins	0	DIRECT
PEBP-like	0	DIRECT
Galactose oxidase, central domain	0	DIRECT
ABC transporter transmembrane region	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Pentein	0	DIRECT
SNF-like	0	DIRECT
SH2 domain	0	DIRECT
LuxS/MPP-like metallohydrolase	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Chitinase insertion domain	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
Small-conductance potassium channel	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
PABC (PABP) domain	0	DIRECT
PGBD-like	0	DIRECT
Tim10-like	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
TAZ domain	0	DIRECT
Phospholipase D/nuclease	0	DIRECT
PLP-binding barrel	0	DIRECT
PAZ domain	0	DIRECT

Family domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Mammalian PLC	0	DIRECT
F-box domain	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
Integrin A (or I) domain	0	DIRECT
Ephrin ectodomain	0	DIRECT
CO dehydrogenase flavoprotein N-terminal domain-like	0	DIRECT
Filamin repeat (rod domain)	0	DIRECT
Poly(A) polymerase, PAP, C-terminal domain	0	DIRECT
Pancreatic carboxypeptidases	0	DIRECT
Pancreatic carboxypeptidase, activation domain	0	DIRECT
UBA domain	0	DIRECT
PhzC/PhzF-like	0	DIRECT
MIT domain	0	DIRECT
FHA domain	0	DIRECT
Reprolysin-like	0	DIRECT
Chitinase insertion domain	0	DIRECT
Neutral endopeptidase (neprilysin)	0	DIRECT
NTF2-like	0	DIRECT
Hydantoinase (dihydropyrimidinase)	0	DIRECT
La domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain	0	DIRECT
Family 19 glycosidase	0	DIRECT
Purple acid phosphatase-like	0	DIRECT
EF-hand modules in multidomain proteins	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
SWIRM domain	0	DIRECT
Polo-box duplicated region	0	DIRECT
Ngr ectodomain-like	0	DIRECT
MFPT repeat	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
Rhomboid-like	0	DIRECT
Cadherin	0	DIRECT
Ammonium transporter	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
Serpins	0	DIRECT
Acylamino-acid-releasing enzyme, C-terminal donain	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Pleckstrin-homology domain (PH domain)	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Proprotein convertase P-domain	0	DIRECT
PABC (PABP) domain	0	DIRECT
STAR domain	0	DIRECT
Arylamine N-methyltransferase	0	DIRECT
Sema domain	0	DIRECT
Translational machinery components	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
Subtilases	0	DIRECT
BAR domain	0	DIRECT
UDPGT-like	0	DIRECT
Phoshoinositide 3-kinase (PI3K), catalytic domain	0	DIRECT
Eps15 homology domain (EH domain)	0	DIRECT
beta-Lactamase/D-ala carboxypeptidase	0	DIRECT
B-box zinc-binding domain	0	DIRECT
GAS2 domain	0	DIRECT
Hermes transposase-like	0	DIRECT
PR-1-like	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
First domain of FERM	0	DIRECT
Aminoacid dehydrogenase-like, C-terminal domain	0	DIRECT
PP2C-like	0	DIRECT
Osmotin, thaumatin-like protein	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
Internalin LRR domain	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
TAZ domain	0	DIRECT
Elafin-like	0	DIRECT
I set domains	0	DIRECT
CoA transferase alpha subunit-like	0	DIRECT
Hedgehog C-terminal (Hog) autoprocessing domain	0	DIRECT
Ribosomal protein L18 and S11	0	DIRECT
SNF-like	0	DIRECT
Leukotriene A4 hydrolase catalytic domain	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
Biotinyl/lipoyl-carrier proteins and domains	0	DIRECT
Ribonuclease H	0	DIRECT
PhyH-like	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Matrix metalloproteases, catalytic domain	0	DIRECT
Galectin (animal S-lectin)	0	DIRECT
Nop domain	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
Cytochrome b5	0	DIRECT
Phoshatidylinositol transfer protein, PITP	0	DIRECT
MIR domain	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
Third domain of FERM	0	DIRECT
RIO1-like kinases	0	DIRECT
SMAD domain	0	DIRECT
Troponin I	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Bromodomain	0	DIRECT
Bacterial lipase	0	DIRECT
Peptidylglycine alpha-hydroxylating monooxygenase, PHM	0	DIRECT
Apyrase	0	DIRECT
RecA protein-like (ATPase-domain)	0	DIRECT
L-arabinose binding protein-like	0	DIRECT
WWE domain	0	DIRECT
XPF/Rad1/Mus81 nuclease	0	DIRECT
SH2 domain	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Purine and uridine phosphorylases	0	DIRECT
NADPH-cytochrome p450 reductase-like	0	DIRECT
Bactericidal permeability-increasing protein, BPI	0	DIRECT
alpha-catenin/vinculin	0	DIRECT
Oxysterol-binding protein	0	DIRECT
Histone lysine methyltransferases	0	DIRECT
CBS-domain pair	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
ARID domain	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
Protein prenyltransferases	0	DIRECT
Aminomethyltransferase folate-binding domain	0	DIRECT
D-aminoacid oxidase-like	0	DIRECT
UDP-glucose pyrophosphorylase	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
Hsp90 middle domain	0	DIRECT
Phosphatidylethanolamine binding protein	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
Hormone receptor domain	0	DIRECT
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta	0	DIRECT
Sterol carrier protein, SCP	0	DIRECT
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
Phoshoinositide 3-kinase (PI3K) helical domain	0	DIRECT
Reductases	0	DIRECT
Acyl-CoA thioesterase	0	DIRECT
LEM domain	0	DIRECT
POU-specific domain	0	DIRECT
Glycerophosphoryl diester phosphodiesterase	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
Glutamine synthetase catalytic domain	0	DIRECT
Arginine methyltransferase	0	DIRECT
Mob1/phocein	0	DIRECT
PEP carboxykinase C-terminal domain	0	DIRECT
CRAL/TRIO domain	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
Smr domain	0	DIRECT
RNA-polymerase beta	0	DIRECT
Autophagin-like	0	DIRECT
Integrin domains	0	DIRECT
Sec63 C-terminal domain-like	0	DIRECT
BC ATP-binding domain-like	0	DIRECT
NagD-like	0	DIRECT
Carbonic anhydrase	0	DIRECT
Sir2 family of transcriptional regulators	0	DIRECT
alpha-mannosidase	0	DIRECT
SAM (sterile alpha motif) domain	0	DIRECT
Inositol monophosphatase/fructose-1,6-bisphosphatase-like	0	DIRECT
Cation efflux protein transmembrane domain-like	0	DIRECT
Histidine acid phosphatase	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
FF domain	0	DIRECT
Ribonucleotide reductase-like	0	DIRECT
DEATH domain, DD	0	DIRECT
Doublecortin (DC)	0	DIRECT
beta 1,4 galactosyltransferase (b4GalT1)	0	DIRECT
HEAT repeat	0	DIRECT
Phosphoribosyltransferases (PRTases)	0	DIRECT
Linker histone H1/H5	0	DIRECT
Neurotransmitter-gated ion-channel transmembrane pore	0	DIRECT
Phosphotyrosine-binding domain (PTB)	0	DIRECT
GHMP Kinase, N-terminal domain	0	DIRECT
PHD domain	0	DIRECT
Fibronectin type III	0	DIRECT
CoA-binding domain	0	DIRECT
Elongation factors	0	DIRECT
Clathrin adaptor core protein	0	DIRECT
Trehalase-like	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Neurolysin-like	0	DIRECT
PLC-like (P variant)	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
Proteasome subunits	0	DIRECT
AAT-like	0	DIRECT
acyl-CoA oxidase C-terminal domains	0	DIRECT
Acetylcholinesterase-like	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
Spectrin repeat	0	DIRECT
Aminomethyltransferase beta-barrel domain	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
Patatin	0	DIRECT
Acireductone dioxygenase	0	DIRECT
PUA domain	0	DIRECT
Arfaptin, Rac-binding fragment	0	DIRECT
Glycerol kinase	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
Cell cycle control phosphatase, catalytic domain	0	DIRECT
Glycogenin	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
L domain	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
FAD/NAD-linked reductases, N-terminal and central domains	0	DIRECT
Carboxylesterase	0	DIRECT
Ras-binding domain, RBD	0	DIRECT
cAMP-binding domain	0	DIRECT
GYF domain	0	DIRECT
NLI interacting factor-like phosphatase	0	DIRECT
Lipovitellin-phosvitin complex; beta-sheet shell regions	0	DIRECT
Adenain-like	0	DIRECT
BC C-terminal domain-like	0	DIRECT
FtsH protease domain-like	0	DIRECT
RhoGDI-like	0	DIRECT
eIF1-like	0	DIRECT
Myotubularin-like phosphatases	0	DIRECT
Inositol polyphosphate kinase (IPK)	0	DIRECT
ALDH-like	0	DIRECT
AraD-like aldolase/epimerase	0	DIRECT
Intermediate filament protein, coiled coil region	0	DIRECT
Purple acid phosphatase, N-terminal domain	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	0	DIRECT
alpha-Amylases, C-terminal beta-sheet domain	0	DIRECT
Cytoplasmic domain of inward rectifier potassium channel	0	DIRECT
5' to 3' exonuclease catalytic domain	0	DIRECT
N-acetyl transferase, NAT	0	DIRECT
Polypeptide N-acetylgalactosaminyltransferase 1, N-terminal domain	0	DIRECT
Laminin-type module	0	DIRECT
Gelsolin-like	0	DIRECT
p120GAP domain-like	0	DIRECT
Chromo domain	0	DIRECT
Type II chitinase	0	DIRECT
Anticodon-binding domain	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
LDH N-terminal domain-like	0	DIRECT
LysM domain	0	DIRECT
Calpain large subunit, catalytic domain (domain II)	0	DIRECT
Gastric lipase	0	DIRECT
Multidomain sulfurtransferase (rhodanese)	0	DIRECT
BC N-terminal domain-like	0	DIRECT
Deoxycytidylate deaminase-like	0	DIRECT
HSP20	0	DIRECT
Cyclophilin (peptidylprolyl isomerase)	0	DIRECT
AN1-like Zinc finger	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
Fatty acid binding protein-like	0	DIRECT
Tudor domain	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
Second domain of FERM	0	DIRECT
Myosin rod fragments	0	DIRECT
SAND domain	0	DIRECT
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains	0	DIRECT
PDEase	0	DIRECT
NOL1/NOP2/sun	0	DIRECT
Histone deacetylase, HDAC	0	DIRECT
Biotin dependent carboxylase carboxyltransferase domain	0	DIRECT
PX domain	0	DIRECT
RNA-polymerase beta-prime	0	DIRECT
Astacin	0	DIRECT
EF-G/eEF-2 domains III and V	0	DIRECT
Regulator of chromosome condensation RCC1	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
RNA methyltransferase FtsJ	0	DIRECT
Pyridoxal-dependent decarboxylase	0	DIRECT
Annexin	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
Gamma-glutamyltranspeptidase-like	0	DIRECT
Guanido kinase catalytic domain	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
Carboxypeptidase regulatory domain	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
Class I aldolase	0	DIRECT
Kelch motif	0	DIRECT
Tetramerization domain of potassium channels	0	DIRECT
Phosphate binding protein-like	0	DIRECT
GAPDH-like	0	DIRECT
Ubiquitin activating enzymes (UBA)	0	DIRECT
Poly(ADP-ribose) polymerase, C-terminal domain	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
Pyk2-associated protein beta ARF-GAP domain	0	DIRECT
Serine carboxypeptidase-like	0	DIRECT
Band 7/SPFH domain	0	DIRECT
CUT domain	0	DIRECT
Cytidylyltransferase	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
4HBT-like	0	DIRECT
Cdc48 N-terminal domain-like	0	DIRECT
Aldo-keto reductases (NADP)	0	DIRECT
Mitochondrial carrier	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
Papain-like	0	DIRECT
Catalytic, N-terminal domain of histone methyltransferase Dot1l	0	DIRECT
Ricin B-like	0	DIRECT
U-box	0	DIRECT
Lactate & malate dehydrogenases, C-terminal domain	0	DIRECT
BolA-like	0	DIRECT
H-NOX domain	0	DIRECT
ets domain	0	DIRECT
Complement control module/SCR domain	0	DIRECT
Class I alpha-1;2-mannosidase, catalytic domain	0	DIRECT
ATP-dependent protease Lon (La), catalytic domain	0	DIRECT
ZZ domain	0	DIRECT
Lesion bypass DNA polymerase (Y-family), catalytic domain	0	DIRECT
beta-glycanases	0	DIRECT
YihX-like	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
Hect, E3 ligase catalytic domain	0	DIRECT
acyl-CoA oxidase N-terminal domains	0	DIRECT
Crotonase-like	0	DIRECT
YbiA-like	0	DIRECT
FAD-linked reductases, N-terminal domain	0	DIRECT
Ribonuclease PH domain 1-like	0	DIRECT
DPP6 catalytic domain-like	0	DIRECT
PaaI/YdiI-like	0	DIRECT
LIM domain	0	DIRECT
YicI catalytic domain-like	0	DIRECT
Meta-cation ATPase, catalytic domain P	0	DIRECT
Translation initiation factor eIF4e	0	DIRECT
Dual specificity phosphatase-like	0	DIRECT
Ypt/Rab-GAP domain of gyp1p	0	DIRECT
Small Kunitz-type inhibitors & BPTI-like toxins	0	DIRECT
Tetraspanin	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain	0	DIRECT
Transforming growth factor (TGF)-beta	0	DIRECT
Cofilin-like	0	DIRECT
Ferredoxin reductase FAD-binding domain-like	0	DIRECT
Zf-UBP	0	DIRECT
N-type ATP pyrophosphatases	0	DIRECT
Higher-molecular-weight phosphotyrosine protein phosphatases	0	DIRECT
Pseudouridine synthase I TruA	0	DIRECT
Mo25 protein	0	DIRECT
Cystathionine synthase-like	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
Ribosomal protein L1	0	DIRECT
MIF-related	0	DIRECT
T-box	0	DIRECT
RUN domain	0	DIRECT
Ribokinase-like	0	DIRECT
GABA-aminotransferase-like	0	DIRECT
HAT/Suf repeat	0	DIRECT
L30e/L7ae ribosomal proteins	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
Calpain large subunit, middle domain (domain III)	0	DIRECT
Calcium ATPase, transduction domain A	0	DIRECT
Clc chloride channel	0	DIRECT
MPP-like	0	DIRECT
Double-stranded RNA-binding domain (dsRBD)	0	DIRECT
Class II glutamine amidotransferases	0	DIRECT
COMT-like	0	DIRECT
Myeloperoxidase-like	0	DIRECT
UBX domain	0	DIRECT
Glutaminase	0	DIRECT
Hydantoinase (dihydropyrimidinase), catalytic domain	0	DIRECT
MutT-like	0	DIRECT
HCDH C-domain-like	0	DIRECT
Spermadhesin, CUB domain	0	DIRECT
MIF4G domain-like	0	DIRECT
Metal cation-transporting ATPase, ATP-binding domain N	0	DIRECT
CalX-beta domain	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
28-residue LRR	0	DIRECT
HMG-box	0	DIRECT
PAZ domain	0	DIRECT
Tim10/DDP	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
Rap/Ran-GAP	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Arylsulfatase	0	DIRECT
CAT-like	0	DIRECT
HD domain	0	DIRECT
Fungal lipases	0	DIRECT
Choline/Carnitine O-acyltransferase	0	DIRECT
LacY-like proton/sugar symporter	0	DIRECT
Heme-dependent catalases	0	DIRECT
N-acetylglucosaminyltransferase I	0	DIRECT
Erythroid transcription factor GATA-1	0	DIRECT
Sm motif of small nuclear ribonucleoproteins, SNRNP	0	DIRECT
Rv2717c-like	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
Amylase, catalytic domain	0	DIRECT
RNA editing terminal uridyl transferase 2, RET2, domain 2	0	DIRECT
ATI-like	0	DIRECT
Inositol polyphosphate 5-phosphatase (IPP5)	0	DIRECT
Aquaporin-like	0	DIRECT
Caspase catalytic domain	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
Kix domain of CBP (creb binding protein)	0	DIRECT
Sec63 N-terminal domain	0	DIRECT
Epoxide hydrolase	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
Ankyrin repeat	0	DIRECT
alpha-mannosidase, domain 2	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Cell cycle transcription factor e2f-dp	0	DIRECT
Lipovitellin-phosvitin complex, superhelical domain	0	DIRECT
Synaptotagmin-like (S variant)	0	DIRECT
BEACH domain	0	DIRECT
TBP-associated factors, TAFs	0	DIRECT
Calcium ATPase, transmembrane domain M	0	DIRECT
Ganglioside M2 (gm2) activator	0	DIRECT
Ras GEF	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
ABC transporter transmembrane region	0	DIRECT
Dimeric isocitrate & isopropylmalate dehydrogenases	0	DIRECT
Formate/glycerate dehydrogenases, NAD-domain	0	DIRECT
Choline kinase	0	DIRECT
Methionine aminopeptidase, insert domain	0	DIRECT
Poly(A) polymerase, PAP, middle domain	0	DIRECT
Extended PAW domain	0	DIRECT
L-aminoacid/polyamine oxidase	0	DIRECT
E2F dimerization segment	0	DIRECT
SAP domain	0	DIRECT
Bacterial dinuclear zinc exopeptidases	0	DIRECT
Serum paraoxonase/arylesterase 1, PON1	0	DIRECT
FCH domain	0	DIRECT
Classic zinc finger, C2H2	0	DIRECT
NADPH-cytochrome p450 reductase FAD-binding domain-like	0	DIRECT
Plexin repeat	0	DIRECT
SMAD MH1 domain	0	DIRECT
1,3-glucuronyltransferase	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
Sec7 domain	0	DIRECT
IF2B-like	0	DIRECT
beta-CASP RNA-metabolising hydrolases	0	DIRECT
Glycerol-3-phosphate transporter	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
D-aminoacid oxidase, N-terminal domain	0	DIRECT
Kinase associated domain 1, KA1	0	DIRECT
WGR domain	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
Transcriptional factor domain	0	DIRECT
Hemopexin-like domain	0	DIRECT
AMPK-beta glycogen binding domain-like	0	DIRECT
Adenylyl and guanylyl cyclase catalytic domain	0	DIRECT
Protein serine/threonine phosphatase	0	DIRECT
Laminin G-like module	0	DIRECT
WW domain	0	DIRECT
PDI-like	0	DIRECT
2Fe-2S ferredoxin domains from multidomain proteins	0	DIRECT
NHL repeat	0	DIRECT
Pepsin-like	0	DIRECT
Small-conductance potassium channel	0	DIRECT
t-snare proteins	0	DIRECT
alpha-mannosidase, C-terminal domain	0	DIRECT
Hemocyanin middle domain	0	DIRECT
TatD Mg-dependent DNase-like	0	DIRECT
Adenosine/AMP deaminase	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
Poly(A) polymerase, PAP, N-terminal domain	0	DIRECT
Hexokinase	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
Clathrin coat assembly domain	0	DIRECT