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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

• Disease Ontology (DO) Ontology (DO)
  DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
  
• Human Phenotype (HP) Ontology (HP)
  HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
  
• Mouse Phenotype (MP) Ontology (MP)
  MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
  
• Worm Phenotype (WP) Ontology (WP)
  WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
  
• Yeast Phenotype (YP) Ontology (YP)
  Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
  
• Fly Phenotype (FP) Ontology (FP)
  FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
  
• Fly Anatomy (FA) Ontology (FA)
  FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
  
• Zebrafish Anatomy (ZA) Ontology (ZA)
  ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
  
• Xenopus Anatomy (XA) Ontology (XA)
  XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
  
• Arabidopsis Plant Ontology (AP) Ontology (AP)
  As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
  
• Enzyme Commission (EC) Ontology (EC)
  Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
  
• DrugBank ATC (DB) Ontology (DB)
  In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
  
• UniProtKB KeyWords (KW) Ontology (KW)
  Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
  
• UniProtKB UniPathway (UP) Ontology (UP)
  UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
  

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
  

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
  

Superfamily domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Annexin	0	DIRECT
SPOC domain-like	0	DIRECT
Polo-box domain	0	DIRECT
Carbon-nitrogen hydrolase	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
Pentein	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
RCC1/BLIP-II	0	DIRECT
ABC transporter transmembrane region	0	DIRECT
MIT domain	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
SMAD MH1 domain	0	DIRECT
Hairpin loop containing domain-like	0	DIRECT
LDH C-terminal domain-like	0	DIRECT
MFPT repeat-like	0	DIRECT
Activating enzymes of the ubiquitin-like proteins	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
Phosphoglycerate mutase-like	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
WGR domain-like	0	DIRECT
Tricorn protease domain 2	0	DIRECT
Mob1/phocein	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Metal cation-transporting ATPase, ATP-binding domain N	0	DIRECT
PIN domain-like	0	DIRECT
SMR domain-like	0	DIRECT
Acid phosphatase/Vanadium-dependent haloperoxidase	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
LEM domain	0	DIRECT
Actin-crosslinking proteins	0	DIRECT
Heme-dependent peroxidases	0	DIRECT
L-aspartase-like	0	DIRECT
Acyl-CoA dehydrogenase C-terminal domain-like	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
DHS-like NAD/FAD-binding domain	0	DIRECT
Small-conductance potassium channel	0	DIRECT
Rap/Ran-GAP	0	DIRECT
ISP domain	0	DIRECT
BPTI-like	0	DIRECT
t-snare proteins	0	DIRECT
PGBD-like	0	DIRECT
FtsH protease domain-like	0	DIRECT
Sec7 domain	0	DIRECT
Periplasmic binding protein-like I	0	DIRECT
MIR domain	0	DIRECT
Periplasmic binding protein-like II	0	DIRECT
LysM domain	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
RUN domain-like	0	DIRECT
PreATP-grasp domain	0	DIRECT
Zinc beta-ribbon	0	DIRECT
Complement control module/SCR domain	0	DIRECT
Osmotin, thaumatin-like protein	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
SAICAR synthase-like	0	DIRECT
Clc chloride channel	0	DIRECT
Ricin B-like lectins	0	DIRECT
BolA-like	0	DIRECT
MgtE membrane domain-like	0	DIRECT
C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
YbiA-like	0	DIRECT
CalX-like	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
Subdomain of clathrin and coatomer appendage domain	0	DIRECT
The spindle assembly checkpoint protein mad2	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Acyl-CoA N-acyltransferases (Nat)	0	DIRECT
FAD-linked oxidases, C-terminal domain	0	DIRECT
Molybdenum cofactor biosynthesis proteins	0	DIRECT
SAND domain-like	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
CBS-domain pair	0	DIRECT
Class I glutamine amidotransferase-like	0	DIRECT
Cysteine-rich domain	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0	DIRECT
Phospholipase D/nuclease	0	DIRECT
Doublecortin (DC)	0	DIRECT
PLP-binding barrel	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
Mss4-like	0	DIRECT
R3H domain	0	DIRECT
Transcription factor IIA (TFIIA), alpha-helical domain	0	DIRECT
Chitinase insertion domain	0	DIRECT
Kringle-like	0	DIRECT
2Fe-2S ferredoxin-like	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
PABC (PABP) domain	0	DIRECT
Elafin-like	0	DIRECT
Nucleotide cyclase	0	DIRECT
NagB/RpiA/CoA transferase-like	0	DIRECT
Hedgehog/intein (Hint) domain	0	DIRECT
Ribosomal protein L1	0	DIRECT
Intermediate filament protein, coiled coil region	0	DIRECT
Galactose oxidase, central domain	0	DIRECT
Carbohydrate phosphatase	0	DIRECT
Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
Tautomerase/MIF	0	DIRECT
Nudix	0	DIRECT
CBD9-like	0	DIRECT
Cyclophilin-like	0	DIRECT
Ferritin-like	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
Lysozyme-like	0	DIRECT
Ammonium transporter	0	DIRECT
GHMP Kinase, C-terminal domain	0	DIRECT
PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	DIRECT
Myosin rod fragments	0	DIRECT
Ribulose-phoshate binding barrel	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Isocitrate/Isopropylmalate dehydrogenase-like	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
SGNH hydrolase	0	DIRECT
WWE domain	0	DIRECT
eIF4e-like	0	DIRECT
Immunoglobulin	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
Aldolase	0	DIRECT
Translation proteins SH3-like domain	0	DIRECT
alpha-catenin/vinculin-like	0	DIRECT
HD-domain/PDEase-like	0	DIRECT
RmlC-like cupins	0	DIRECT
BEACH domain	0	DIRECT
HIT/MYND zinc finger-like	0	DIRECT
ADC-like	0	DIRECT
HMG-box	0	DIRECT
Thioesterase/thiol ester dehydrase-isomerase	0	DIRECT
SpoIIaa-like	0	DIRECT
Heme-dependent catalase-like	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
Calpain large subunit, middle domain (domain III)	0	DIRECT
Galactose mutarotase-like	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
Hormone receptor domain	0	DIRECT
PYP-like sensor domain (PAS domain)	0	DIRECT
Ferredoxin reductase-like, C-terminal NADP-linked domain	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
Aquaporin-like	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
Cytidine deaminase-like	0	DIRECT
Acid proteases	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
SCP-like	0	DIRECT
Protease propeptides/inhibitors	0	DIRECT
Subtilisin-like	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
PAP/OAS1 substrate-binding domain	0	DIRECT
HIT-like	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
SAP domain	0	DIRECT
Cation efflux protein transmembrane domain-like	0	DIRECT
Metallo-dependent hydrolases	0	DIRECT
cAMP-binding domain-like	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
ClpP/crotonase	0	DIRECT
Transcription factor IIA (TFIIA), beta-barrel domain	0	DIRECT
Nucleotidyltransferase	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
Radical SAM enzymes	0	DIRECT
Cytochrome c	0	DIRECT
Restriction endonuclease-like	0	DIRECT
Alpha-L RNA-binding motif	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
Tubby C-terminal domain-like	0	DIRECT
Calcium ATPase, transmembrane domain M	0	DIRECT
Rhomboid-like	0	DIRECT
TAZ domain	0	DIRECT
Plexin repeat	0	DIRECT
Tudor/PWWP/MBT	0	DIRECT
Spermadhesin, CUB domain	0	DIRECT
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
Flavoproteins	0	DIRECT
Sema domain	0	DIRECT
Aminoacid dehydrogenase-like, N-terminal domain	0	DIRECT
Nucleoporin domain	0	DIRECT
BAR/IMD domain-like	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Integrin domains	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
Glycosyl hydrolase domain	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
TK C-terminal domain-like	0	DIRECT
Diaminopimelate epimerase-like	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
Kix domain of CBP (creb binding protein)	0	DIRECT
Metallo-hydrolase/oxidoreductase	0	DIRECT
p53-like transcription factors	0	DIRECT
Translational machinery components	0	DIRECT
Nop domain	0	DIRECT
beta-lactamase/transpeptidase-like	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
L30e-like	0	DIRECT
Ganglioside M2 (gm2) activator	0	DIRECT
Purple acid phosphatase, N-terminal domain	0	DIRECT
B-box zinc-binding domain	0	DIRECT
GAS2 domain-like	0	DIRECT
Spectrin repeat	0	DIRECT
Rudiment single hybrid motif	0	DIRECT
PEBP-like	0	DIRECT
lambda repressor-like DNA-binding domains	0	DIRECT
Aminomethyltransferase beta-barrel domain	0	DIRECT
Nucleotide-binding domain	0	DIRECT
ArfGap/RecO-like zinc finger	0	DIRECT
KA1-like	0	DIRECT
Second domain of FERM	0	DIRECT
ALDH-like	0	DIRECT
NTF2-like	0	DIRECT
Fibronectin type III	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
Six-hairpin glycosidases	0	DIRECT
GAT-like domain	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Calcium-dependent phosphotriesterase	0	DIRECT
Phoshotransferase/anion transport protein	0	DIRECT
FF domain	0	DIRECT
alpha-helical ferredoxin	0	DIRECT
Tim10-like	0	DIRECT
PR-1-like	0	DIRECT
Purine and uridine phosphorylases	0	DIRECT
Cystine-knot cytokines	0	DIRECT
Bet v1-like	0	DIRECT
Cupredoxins	0	DIRECT
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0	DIRECT
Riboflavin synthase domain-like	0	DIRECT
NAD(P)-linked oxidoreductase	0	DIRECT
Chromo domain-like	0	DIRECT
BSD domain-like	0	DIRECT
Carbonic anhydrase	0	DIRECT
Terpenoid cyclases/Protein prenyltransferases	0	DIRECT
DNase I-like	0	DIRECT
NHL repeat	0	DIRECT
SET domain	0	DIRECT
RuvA domain 2-like	0	DIRECT
Acyl-CoA dehydrogenase NM domain-like	0	DIRECT
AraD/HMP-PK domain-like	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
Ras GEF	0	DIRECT
Ribosomal protein S18	0	DIRECT
Oxysterol-binding protein-like	0	DIRECT
Glycerol-3-phosphate (1)-acyltransferase	0	DIRECT
PEP carboxykinase-like	0	DIRECT
Invertebrate chitin-binding proteins	0	DIRECT
Cystatin/monellin	0	DIRECT
Families 57/38 glycoside transferase middle domain	0	DIRECT
GYF domain	0	DIRECT
CRAL/TRIO domain	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
EF-G C-terminal domain-like	0	DIRECT
PLC-like phosphodiesterases	0	DIRECT
NAD kinase/diacylglycerol kinase-like	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
Glutamine synthetase/guanido kinase	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
HRDC-like	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Pectin lyase-like	0	DIRECT
Phospholipase A2, PLA2	0	DIRECT
Cadherin-like	0	DIRECT
alpha/beta knot	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
Lipovitellin-phosvitin complex; beta-sheet shell regions	0	DIRECT
CoA-dependent acyltransferases	0	DIRECT
Cytochrome b5-like heme/steroid binding domain	0	DIRECT
Glycoside hydrolase/deacetylase	0	DIRECT
E2F-DP heterodimerization region	0	DIRECT
Carboxypeptidase regulatory domain-like	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
Formate/glycerate dehydrogenase catalytic domain-like	0	DIRECT
AN1-like Zinc finger	0	DIRECT
Bromodomain	0	DIRECT
Alkaline phosphatase-like	0	DIRECT
Creatinase/prolidase N-terminal domain	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
Rhodanese/Cell cycle control phosphatase	0	DIRECT
PRTase-like	0	DIRECT
TIMP-like	0	DIRECT
FAD-binding/transporter-associated domain-like	0	DIRECT
Pseudouridine synthase	0	DIRECT
PUA domain-like	0	DIRECT
Hect, E3 ligase catalytic domain	0	DIRECT
Lipocalins	0	DIRECT
Serine protease inhibitors	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
Putative DNA-binding domain	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
Hemopexin-like domain	0	DIRECT
Adenine nucleotide alpha hydrolases-like	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
Ypt/Rab-GAP domain of gyp1p	0	DIRECT
Clathrin adaptor appendage domain	0	DIRECT
DEATH domain	0	DIRECT
Multidrug resistance efflux transporter EmrE	0	DIRECT
Caspase-like	0	DIRECT
Troponin coil-coiled subunits	0	DIRECT
Folate-binding domain	0	DIRECT
HCP-like	0	DIRECT
Single hybrid motif	0	DIRECT
Mitochondrial cytochrome c oxidase subunit VIc	0	DIRECT
PHM/PNGase F	0	DIRECT
VPS9 domain	0	DIRECT
eIF1-like	0	DIRECT
FAD-linked reductases, C-terminal domain	0	DIRECT
Integrin alpha N-terminal domain	0	DIRECT
WW domain	0	DIRECT
PP2C-like	0	DIRECT
SMAD/FHA domain	0	DIRECT
Arginase/deacetylase	0	DIRECT
Calcium ATPase, transduction domain A	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
Composite domain of metallo-dependent hydrolases	0	DIRECT
Ribokinase-like	0	DIRECT
Di-copper centre-containing domain	0	DIRECT
Outer arm dynein light chain 1	0	DIRECT
Actin depolymerizing proteins	0	DIRECT
PX domain	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
SIS domain	0	DIRECT
Lipovitellin-phosvitin complex, superhelical domain	0	DIRECT
Ribosomal protein S10	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
DNA clamp	0	DIRECT
Phosphoenolpyruvate/pyruvate domain	0	DIRECT
Kelch motif	0	DIRECT
Mitochondrial carrier	0	DIRECT
ADP-ribosylation	0	DIRECT
Sec63 N-terminal domain-like	0	DIRECT
PK beta-barrel domain-like	0	DIRECT
ARID-like	0	DIRECT

Family domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Aminomethyltransferase folate-binding domain	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Ngr ectodomain-like	0	DIRECT
Pepsin-like	0	DIRECT
Histidine acid phosphatase	0	DIRECT
Polo-box duplicated region	0	DIRECT
Arylamine N-methyltransferase	0	DIRECT
Rap/Ran-GAP	0	DIRECT
Pyridoxal-dependent decarboxylase	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
Ribosomal protein L1	0	DIRECT
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta	0	DIRECT
Caspase catalytic domain	0	DIRECT
Cell cycle transcription factor e2f-dp	0	DIRECT
Neurotransmitter-gated ion-channel transmembrane pore	0	DIRECT
UBA domain	0	DIRECT
Ribonuclease H	0	DIRECT
Zf-UBP	0	DIRECT
Acylamino-acid-releasing enzyme, C-terminal donain	0	DIRECT
YbiA-like	0	DIRECT
LysM domain	0	DIRECT
Integrin domains	0	DIRECT
HEAT repeat	0	DIRECT
Integrin A (or I) domain	0	DIRECT
Glycerol kinase	0	DIRECT
Fungal lipases	0	DIRECT
Bacterial dinuclear zinc exopeptidases	0	DIRECT
Serum paraoxonase/arylesterase 1, PON1	0	DIRECT
PaaI/YdiI-like	0	DIRECT
Mitochondrial carrier	0	DIRECT
CoA-binding domain	0	DIRECT
TAZ domain	0	DIRECT
Hexokinase	0	DIRECT
DEATH domain, DD	0	DIRECT
Transforming growth factor (TGF)-beta	0	DIRECT
Gelsolin-like	0	DIRECT
PR-1-like	0	DIRECT
Choline kinase	0	DIRECT
UDP-glucose pyrophosphorylase	0	DIRECT
Biotin dependent carboxylase carboxyltransferase domain	0	DIRECT
L-arabinose binding protein-like	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
Clc chloride channel	0	DIRECT
Intermediate filament protein, coiled coil region	0	DIRECT
Lipovitellin-phosvitin complex, superhelical domain	0	DIRECT
COMT-like	0	DIRECT
FCH domain	0	DIRECT
Aldo-keto reductases (NADP)	0	DIRECT
Polypeptide N-acetylgalactosaminyltransferase 1, N-terminal domain	0	DIRECT
beta-CASP RNA-metabolising hydrolases	0	DIRECT
LacY-like proton/sugar symporter	0	DIRECT
LEM domain	0	DIRECT
PP2C-like	0	DIRECT
NOL1/NOP2/sun	0	DIRECT
Ephrin ectodomain	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
Osmotin, thaumatin-like protein	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
Ypt/Rab-GAP domain of gyp1p	0	DIRECT
GHMP Kinase, N-terminal domain	0	DIRECT
Ras-binding domain, RBD	0	DIRECT
L-aminoacid/polyamine oxidase	0	DIRECT
Tetramerization domain of potassium channels	0	DIRECT
HMG-box	0	DIRECT
Phoshoinositide 3-kinase (PI3K) helical domain	0	DIRECT
BC C-terminal domain-like	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
Galectin (animal S-lectin)	0	DIRECT
Pseudouridine synthase I TruA	0	DIRECT
Hsp90 middle domain	0	DIRECT
Fibronectin type III	0	DIRECT
PDEase	0	DIRECT
ATP-dependent protease Lon (La), catalytic domain	0	DIRECT
La domain	0	DIRECT
2Fe-2S ferredoxin domains from multidomain proteins	0	DIRECT
Histone lysine methyltransferases	0	DIRECT
EF-G/eEF-2 domains III and V	0	DIRECT
YicI catalytic domain-like	0	DIRECT
CUT domain	0	DIRECT
cAMP-binding domain	0	DIRECT
RUN domain	0	DIRECT
beta-Lactamase/D-ala carboxypeptidase	0	DIRECT
CBS-domain pair	0	DIRECT
SAM (sterile alpha motif) domain	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
PhzC/PhzF-like	0	DIRECT
Sterol carrier protein, SCP	0	DIRECT
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)	0	DIRECT
Catalytic, N-terminal domain of histone methyltransferase Dot1l	0	DIRECT
t-snare proteins	0	DIRECT
CoA transferase alpha subunit-like	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Aquaporin-like	0	DIRECT
Ferredoxin reductase FAD-binding domain-like	0	DIRECT
UBX domain	0	DIRECT
RhoGDI-like	0	DIRECT
Internalin LRR domain	0	DIRECT
Phosphoribosyltransferases (PRTases)	0	DIRECT
NagD-like	0	DIRECT
Dimeric isocitrate & isopropylmalate dehydrogenases	0	DIRECT
ABC transporter transmembrane region	0	DIRECT
WGR domain	0	DIRECT
5' to 3' exonuclease catalytic domain	0	DIRECT
AraD-like aldolase/epimerase	0	DIRECT
PLC-like (P variant)	0	DIRECT
BC N-terminal domain-like	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
Choline/Carnitine O-acyltransferase	0	DIRECT
Matrix metalloproteases, catalytic domain	0	DIRECT
Papain-like	0	DIRECT
UDPGT-like	0	DIRECT
CRAL/TRIO N-terminal domain	0	DIRECT
alpha-mannosidase, domain 2	0	DIRECT
BAR domain	0	DIRECT
First domain of FERM	0	DIRECT
Subtilases	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
N-acetyl transferase, NAT	0	DIRECT
Glutamine synthetase catalytic domain	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	0	DIRECT
RNA methyltransferase FtsJ	0	DIRECT
Guanido kinase catalytic domain	0	DIRECT
Cofilin-like	0	DIRECT
ALDH-like	0	DIRECT
Crotonase-like	0	DIRECT
Calcium ATPase, transduction domain A	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
HCDH C-domain-like	0	DIRECT
Fatty acid binding protein-like	0	DIRECT
Elongation factors	0	DIRECT
Ganglioside M2 (gm2) activator	0	DIRECT
Formate/glycerate dehydrogenases, NAD-domain	0	DIRECT
p120GAP domain-like	0	DIRECT
Calcium ATPase, transmembrane domain M	0	DIRECT
AlkB-like	0	DIRECT
Gastric lipase	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
F-box domain	0	DIRECT
ARID domain	0	DIRECT
Reductases	0	DIRECT
Transcription factor IIA (TFIIA), beta-barrel domain	0	DIRECT
LIM domain	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
T-box	0	DIRECT
Phosphate binding protein-like	0	DIRECT
N-acetylglucosaminyltransferase I	0	DIRECT
Cdc48 N-terminal domain-like	0	DIRECT
Poly(A) polymerase, PAP, N-terminal domain	0	DIRECT
BC ATP-binding domain-like	0	DIRECT
Carboxypeptidase regulatory domain	0	DIRECT
Mo25 protein	0	DIRECT
Globins	0	DIRECT
N-type ATP pyrophosphatases	0	DIRECT
GAS2 domain	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
Adenosine/AMP deaminase	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
NTF2-like	0	DIRECT
Anticodon-binding domain	0	DIRECT
Lesion bypass DNA polymerase (Y-family), catalytic domain	0	DIRECT
HSP20	0	DIRECT
eIF1-like	0	DIRECT
Calpain large subunit, middle domain (domain III)	0	DIRECT
CAT-like	0	DIRECT
Phosphotyrosine-binding domain (PTB)	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
Pleckstrin-homology domain (PH domain)	0	DIRECT
Spectrin repeat	0	DIRECT
Sec63 N-terminal domain	0	DIRECT
beta 1,4 galactosyltransferase (b4GalT1)	0	DIRECT
Deoxycytidylate deaminase-like	0	DIRECT
Gamma-glutamyltranspeptidase-like	0	DIRECT
TBP-associated factors, TAFs	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain	0	DIRECT
CO dehydrogenase flavoprotein N-terminal domain-like	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
Transcription factor IIA (TFIIA), alpha-helical domain	0	DIRECT
YihX-like	0	DIRECT
Biotinyl/lipoyl-carrier proteins and domains	0	DIRECT
Transcriptional factor domain	0	DIRECT
L30e/L7ae ribosomal proteins	0	DIRECT
B-box zinc-binding domain	0	DIRECT
Peptidylglycine alpha-hydroxylating monooxygenase, PHM	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Bactericidal permeability-increasing protein, BPI	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
SWIRM domain	0	DIRECT
Phosphatidylethanolamine binding protein	0	DIRECT
MutT-like	0	DIRECT
FHA domain	0	DIRECT
Hedgehog C-terminal (Hog) autoprocessing domain	0	DIRECT
Poly(A) polymerase, PAP, middle domain	0	DIRECT
PEP carboxykinase C-terminal domain	0	DIRECT
Ras GEF	0	DIRECT
Doublecortin (DC)	0	DIRECT
Cation efflux protein transmembrane domain-like	0	DIRECT
Hermes transposase-like	0	DIRECT
WWE domain	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
CalX-beta domain	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
Serine carboxypeptidase-like	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
MIF-related	0	DIRECT
BEACH domain	0	DIRECT
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains	0	DIRECT
Aminomethyltransferase beta-barrel domain	0	DIRECT
Translational machinery components	0	DIRECT
RNA-polymerase beta-prime	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
Tudor domain	0	DIRECT
BolA-like	0	DIRECT
Dual specificity phosphatase-like	0	DIRECT
Ribosomal protein S10	0	DIRECT
SAND domain	0	DIRECT
Cyclophilin (peptidylprolyl isomerase)	0	DIRECT
Vertebrate phospholipase A2	0	DIRECT
PABC (PABP) domain	0	DIRECT
Mammalian PLC	0	DIRECT
Acireductone dioxygenase	0	DIRECT
Inositol polyphosphate kinase (IPK)	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Adenylyl and guanylyl cyclase catalytic domain	0	DIRECT
POU-specific domain	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
Ribosomal protein S18	0	DIRECT
Neurolysin-like	0	DIRECT
Ribokinase-like	0	DIRECT
acyl-CoA oxidase N-terminal domains	0	DIRECT
Astacin	0	DIRECT
Erythroid transcription factor GATA-1	0	DIRECT
Cytoplasmic domain of inward rectifier potassium channel	0	DIRECT
Poly(ADP-ribose) polymerase, C-terminal domain	0	DIRECT
Rhomboid-like	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
SAP domain	0	DIRECT
Chitinase insertion domain	0	DIRECT
Clathrin coat assembly domain	0	DIRECT
Filamin repeat (rod domain)	0	DIRECT
Ubiquitin activating enzymes (UBA)	0	DIRECT
Lactate & malate dehydrogenases, C-terminal domain	0	DIRECT
RNA-polymerase beta	0	DIRECT
Glycerol-3-phosphate transporter	0	DIRECT
Classic zinc finger, C2H2	0	DIRECT
Inositol polyphosphate 5-phosphatase (IPP5)	0	DIRECT
AN1-like Zinc finger	0	DIRECT
alpha-mannosidase	0	DIRECT
LDH N-terminal domain-like	0	DIRECT
Trehalase-like	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
DPP6 catalytic domain-like	0	DIRECT
Class II glutamine amidotransferases	0	DIRECT
Hydantoinase (dihydropyrimidinase)	0	DIRECT
4HBT-like	0	DIRECT
PX domain	0	DIRECT
Tim10/DDP	0	DIRECT
Ammonium transporter	0	DIRECT
Ribonuclease PH domain 1-like	0	DIRECT
PDI-like	0	DIRECT
U-box	0	DIRECT
Amylase, catalytic domain	0	DIRECT
H-NOX domain	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
Arfaptin, Rac-binding fragment	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
NADPH-cytochrome p450 reductase FAD-binding domain-like	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
TatD Mg-dependent DNase-like	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
ets domain	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
Mob1/phocein	0	DIRECT
Sm motif of small nuclear ribonucleoproteins, SNRNP	0	DIRECT
NADPH-cytochrome p450 reductase-like	0	DIRECT
Sec63 C-terminal domain-like	0	DIRECT
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain	0	DIRECT
E2F dimerization segment	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
FAD/NAD-linked reductases, N-terminal and central domains	0	DIRECT
Second domain of FERM	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
Patatin	0	DIRECT
RIO1-like kinases	0	DIRECT
Purple acid phosphatase, N-terminal domain	0	DIRECT
Reprolysin-like	0	DIRECT
Glycogenin	0	DIRECT
Sema domain	0	DIRECT
Methionine aminopeptidase, insert domain	0	DIRECT
Pancreatic carboxypeptidases	0	DIRECT
Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
Oxysterol-binding protein	0	DIRECT
1,3-glucuronyltransferase	0	DIRECT
Cytidylyltransferase	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
Sir2 family of transcriptional regulators	0	DIRECT
Chromo domain	0	DIRECT
Carbonic anhydrase	0	DIRECT
Arylsulfatase	0	DIRECT
Myotubularin-like phosphatases	0	DIRECT
Regulator of chromosome condensation RCC1	0	DIRECT
Third domain of FERM	0	DIRECT
Proteasome subunits	0	DIRECT
Plexin repeat	0	DIRECT
FF domain	0	DIRECT
Hemocyanin middle domain	0	DIRECT
Type II chitinase	0	DIRECT
Band 7/SPFH domain	0	DIRECT
Spermadhesin, CUB domain	0	DIRECT
Acyl-CoA thioesterase	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
STAR domain	0	DIRECT
MIT domain	0	DIRECT
SMAD MH1 domain	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
Purine and uridine phosphorylases	0	DIRECT
Glutaminase	0	DIRECT
Sec7 domain	0	DIRECT
beta-glycanases	0	DIRECT
Linker histone H1/H5	0	DIRECT
Elafin-like	0	DIRECT
Cytochrome b5	0	DIRECT
28-residue LRR	0	DIRECT
XPF/Rad1/Mus81 nuclease	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
Purple acid phosphatase-like	0	DIRECT
Pyk2-associated protein beta ARF-GAP domain	0	DIRECT
CRAL/TRIO domain	0	DIRECT
Proton glutamate symport protein	0	DIRECT
MIF4G domain-like	0	DIRECT
Proprotein convertase P-domain	0	DIRECT
Bromodomain	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
Bacterial lipase	0	DIRECT
IF2B-like	0	DIRECT
PUA domain	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
SMAD domain	0	DIRECT
BSD domain	0	DIRECT
HAT/Suf repeat	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
Smr domain	0	DIRECT
NLI interacting factor-like phosphatase	0	DIRECT
alpha-mannosidase, C-terminal domain	0	DIRECT
Hemopexin-like domain	0	DIRECT
I set domains	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
Troponin I	0	DIRECT
Translation initiation factor eIF4e	0	DIRECT
Clathrin adaptor core protein	0	DIRECT
Lipovitellin-phosvitin complex; beta-sheet shell regions	0	DIRECT
Arginine methyltransferase	0	DIRECT
Leukotriene A4 hydrolase catalytic domain	0	DIRECT
Myeloperoxidase-like	0	DIRECT
Family 19 glycosidase	0	DIRECT
Autophagin-like	0	DIRECT
Metal cation-transporting ATPase, ATP-binding domain N	0	DIRECT
PhyH-like	0	DIRECT
Heme-dependent catalases	0	DIRECT
ATI-like	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
Carboxylesterase	0	DIRECT
Rv2717c-like	0	DIRECT
Ricin B-like	0	DIRECT
D-aminoacid oxidase, N-terminal domain	0	DIRECT
Pancreatic carboxypeptidase, activation domain	0	DIRECT
Glycerophosphoryl diester phosphodiesterase	0	DIRECT
Class I glutamine amidotransferases (GAT)	0	DIRECT
Complement control module/SCR domain	0	DIRECT
Cell cycle control phosphatase, catalytic domain	0	DIRECT
Eps15 homology domain (EH domain)	0	DIRECT
Nop domain	0	DIRECT
Small Kunitz-type inhibitors & BPTI-like toxins	0	DIRECT
Histone deacetylase, HDAC	0	DIRECT
Cadherin	0	DIRECT
FAD-linked reductases, N-terminal domain	0	DIRECT
Ribosomal protein L18 and S11	0	DIRECT
Protein prenyltransferases	0	DIRECT
Multidomain sulfurtransferase (rhodanese)	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
MIR domain	0	DIRECT
Adenain-like	0	DIRECT
Class I aldolase	0	DIRECT
Laminin-type module	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
Hydantoinase (dihydropyrimidinase), catalytic domain	0	DIRECT
EF-hand modules in multidomain proteins	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
alpha-catenin/vinculin	0	DIRECT
Hormone receptor domain	0	DIRECT
Epoxide hydrolase	0	DIRECT
Aminoacid dehydrogenase-like, C-terminal domain	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
GAPDH-like	0	DIRECT
Kelch motif	0	DIRECT
Kinase associated domain 1, KA1	0	DIRECT
WW domain	0	DIRECT
NHL repeat	0	DIRECT
acyl-CoA oxidase C-terminal domains	0	DIRECT
Kix domain of CBP (creb binding protein)	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
GYF domain	0	DIRECT
Synaptotagmin-like (S variant)	0	DIRECT
L domain	0	DIRECT
Small-conductance potassium channel	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
Laminin G-like module	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
Hect, E3 ligase catalytic domain	0	DIRECT
RNA editing terminal uridyl transferase 2, RET2, domain 2	0	DIRECT
ZZ domain	0	DIRECT
Calpain large subunit, catalytic domain (domain II)	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
RecA protein-like (ATPase-domain)	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Phoshoinositide 3-kinase (PI3K), catalytic domain	0	DIRECT
GABA-aminotransferase-like	0	DIRECT
Tetraspanin	0	DIRECT
Phoshatidylinositol transfer protein, PITP	0	DIRECT
D-aminoacid oxidase-like	0	DIRECT
HD domain	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Cystathionine synthase-like	0	DIRECT
Inositol monophosphatase/fructose-1,6-bisphosphatase-like	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
Class I alpha-1;2-mannosidase, catalytic domain	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
FtsH protease domain-like	0	DIRECT
alpha-Amylases, C-terminal beta-sheet domain	0	DIRECT
Poly(A) polymerase, PAP, C-terminal domain	0	DIRECT
MFPT repeat	0	DIRECT
Annexin	0	DIRECT
Myosin rod fragments	0	DIRECT
Meta-cation ATPase, catalytic domain P	0	DIRECT
AMPK-beta glycogen binding domain-like	0	DIRECT