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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

• Disease Ontology (DO) Ontology (DO)
  DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
  
• Human Phenotype (HP) Ontology (HP)
  HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
  
• Mouse Phenotype (MP) Ontology (MP)
  MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
  
• Worm Phenotype (WP) Ontology (WP)
  WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
  
• Yeast Phenotype (YP) Ontology (YP)
  Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
  
• Fly Phenotype (FP) Ontology (FP)
  FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
  
• Fly Anatomy (FA) Ontology (FA)
  FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
  
• Zebrafish Anatomy (ZA) Ontology (ZA)
  ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
  
• Xenopus Anatomy (XA) Ontology (XA)
  XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
  
• Arabidopsis Plant Ontology (AP) Ontology (AP)
  As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
  
• Enzyme Commission (EC) Ontology (EC)
  Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
  
• DrugBank ATC (DB) Ontology (DB)
  In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
  
• UniProtKB KeyWords (KW) Ontology (KW)
  Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
  
• UniProtKB UniPathway (UP) Ontology (UP)
  UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
  

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
  

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
  

Superfamily domains annotated to this WP term (SDWP level: Least Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
FtsH protease domain-like	0	DIRECT
Tubby C-terminal domain-like	0	DIRECT
Ribosomal protein L1	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
Heme-dependent catalase-like	0	DIRECT
LysM domain	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Cystatin/monellin	0	DIRECT
Tryptophan synthase beta subunit-like PLP-dependent enzymes	0	DIRECT
CBD9-like	0	DIRECT
AN1-like Zinc finger	0	DIRECT
MIR domain	0	DIRECT
Formate/glycerate dehydrogenase catalytic domain-like	0	DIRECT
HRDC-like	0	DIRECT
Carbohydrate phosphatase	0	DIRECT
ADP-ribosylation	0	DIRECT
GroEL equatorial domain-like	0	DIRECT
SAND domain-like	0	DIRECT
ArfGap/RecO-like zinc finger	0	DIRECT
R3H domain	0	DIRECT
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
beta-lactamase/transpeptidase-like	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
Galactose oxidase, central domain	0	DIRECT
MgtE membrane domain-like	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
WGR domain-like	0	DIRECT
Doublecortin (DC)	0	DIRECT
eIF4e-like	0	DIRECT
Citrate synthase	0	DIRECT
Terpenoid synthases	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
Oxysterol-binding protein-like	0	DIRECT
LEM domain	0	DIRECT
PHM/PNGase F	0	DIRECT
PK beta-barrel domain-like	0	DIRECT
Phoshotransferase/anion transport protein	0	DIRECT
VPS9 domain	0	DIRECT
Creatinase/prolidase N-terminal domain	0	DIRECT
Arginase/deacetylase	0	DIRECT
Complement control module/SCR domain	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
SPOC domain-like	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
FAD-linked oxidases, C-terminal domain	0	DIRECT
Rap/Ran-GAP	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Nucleoporin domain	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
MFPT repeat-like	0	DIRECT
GAS2 domain-like	0	DIRECT
Terpenoid cyclases/Protein prenyltransferases	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
Tricorn protease domain 2	0	DIRECT
Hormone receptor domain	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
ARID-like	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
alpha/beta knot	0	DIRECT
Sec7 domain	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
Phosphoenolpyruvate/pyruvate domain	0	DIRECT
14-3-3 protein	0	DIRECT
LDH C-terminal domain-like	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Cytochrome c	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
Subtilisin-like	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
Small-conductance potassium channel	0	DIRECT
HSP20-like chaperones	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
Integrin alpha N-terminal domain	0	DIRECT
2Fe-2S ferredoxin-like	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
PABC (PABP) domain	0	DIRECT
Heme-dependent peroxidases	0	DIRECT
Restriction endonuclease-like	0	DIRECT
Chitinase insertion domain	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Radical SAM enzymes	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
Chaperone J-domain	0	DIRECT
Annexin	0	DIRECT
PEBP-like	0	DIRECT
JAB1/MPN domain	0	DIRECT
Pentein	0	DIRECT
FAD-binding/transporter-associated domain-like	0	DIRECT
Hedgehog/intein (Hint) domain	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
Ribosomal protein S10	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
GroEL apical domain-like	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
GYF domain	0	DIRECT
Zn-binding ribosomal proteins	0	DIRECT
Acid phosphatase/Vanadium-dependent haloperoxidase	0	DIRECT
PEP carboxykinase-like	0	DIRECT
TGS-like	0	DIRECT
Diaminopimelate epimerase-like	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
FF domain	0	DIRECT
Ribokinase-like	0	DIRECT
ThrRS/AlaRS common domain	0	DIRECT
Protease propeptides/inhibitors	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
L-aspartase-like	0	DIRECT
Outer arm dynein light chain 1	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Elafin-like	0	DIRECT
Cadherin-like	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
PapD-like	0.0004448	DIRECT
Mitochondrial carrier	0.0007718	DIRECT
POZ domain	0.004746	INHERITED FROM: early larval arrest || L1 arrest
Ribosomal protein S5 domain 2-like	0.2154	INHERITED FROM: early larval arrest
Protein kinase-like (PK-like)	0.2963	INHERITED FROM: mid larval arrest
Quinoprotein alcohol dehydrogenase-like	0.383	INHERITED FROM: L2 arrest || mid larval arrest
Translation proteins SH3-like domain	0.4236	INHERITED FROM: early larval arrest
WD40 repeat-like	0.5312	INHERITED FROM: early larval arrest || late larval arrest
UBC-like	0.6138	INHERITED FROM: late larval arrest
Ribonuclease PH domain 2-like	0.7417	INHERITED FROM: early larval arrest

Family domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Ribosomal protein S10	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
RNA-polymerase beta-prime	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
Sec7 domain	0	DIRECT
XPF/Rad1/Mus81 nuclease	0	DIRECT
Serum paraoxonase/arylesterase 1, PON1	0	DIRECT
COMT-like	0	DIRECT
Type II chitinase	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
YihX-like	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
NTF2-like	0	DIRECT
Protein prenyltransferases	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Paired domain	0	DIRECT
VHS domain	0	DIRECT
GYF domain	0	DIRECT
AMPK-beta glycogen binding domain-like	0	DIRECT
U-box	0	DIRECT
D-aminoacid oxidase-like	0	DIRECT
Proprotein convertase P-domain	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
beta-Lactamase/D-ala carboxypeptidase	0	DIRECT
Hexokinase	0	DIRECT
Oxysterol-binding protein	0	DIRECT
DPP6 catalytic domain-like	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
CO dehydrogenase flavoprotein N-terminal domain-like	0	DIRECT
Gamma-glutamyltranspeptidase-like	0	DIRECT
LysM domain	0	DIRECT
Tryptophan synthase beta subunit-like PLP-dependent enzymes	0	DIRECT
Chitinase insertion domain	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
Brix domain	0	DIRECT
NHL repeat	0	DIRECT
Group II chaperonin (CCT, TRIC), ATPase domain	0	DIRECT
Group II chaperonin (CCT, TRIC), apical domain	0	DIRECT
Inositol monophosphatase/fructose-1,6-bisphosphatase-like	0	DIRECT
SAM (sterile alpha motif) domain	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Ribokinase-like	0	DIRECT
Poly(ADP-ribose) polymerase, C-terminal domain	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Clathrin coat assembly domain	0	DIRECT
Hsp90 middle domain	0	DIRECT
GAS2 domain	0	DIRECT
Lactate & malate dehydrogenases, C-terminal domain	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
CoA-binding domain	0	DIRECT
NOL1/NOP2/sun	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
IF2B-like	0	DIRECT
Cytoplasmic domain of inward rectifier potassium channel	0	DIRECT
LEM domain	0	DIRECT
Choline kinase	0	DIRECT
DEP domain	0	DIRECT
Citrate synthase	0	DIRECT
Phosphatidylethanolamine binding protein	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
Histone deacetylase, HDAC	0	DIRECT
RhoGDI-like	0	DIRECT
Hedgehog C-terminal (Hog) autoprocessing domain	0	DIRECT
Vertebrate phospholipase A2	0	DIRECT
Sec63 N-terminal domain	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
SWIRM domain	0	DIRECT
Translation initiation factor eIF4e	0	DIRECT
Tetraspanin	0	DIRECT
Calpain large subunit, catalytic domain (domain II)	0	DIRECT
PUA domain	0	DIRECT
YicI catalytic domain-like	0	DIRECT
Doublecortin (DC)	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
Myotubularin-like phosphatases	0	DIRECT
acyl-CoA oxidase C-terminal domains	0	DIRECT
Rap/Ran-GAP	0	DIRECT
PDI-like	0	DIRECT
PhzC/PhzF-like	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
Arylsulfatase	0	DIRECT
SAND domain	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
HD domain	0	DIRECT
WGR domain	0	DIRECT
Pyk2-associated protein beta ARF-GAP domain	0	DIRECT
Glycogenin	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
CAT-like	0	DIRECT
Hydantoinase (dihydropyrimidinase)	0	DIRECT
DEATH domain, DD	0	DIRECT
Annexin	0	DIRECT
Cadherin	0	DIRECT
Sec63 C-terminal domain-like	0	DIRECT
Ribosomal protein L1	0	DIRECT
D-aminoacid oxidase, N-terminal domain	0	DIRECT
Peptidylglycine alpha-hydroxylating monooxygenase, PHM	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
PABC (PABP) domain	0	DIRECT
Inositol polyphosphate 5-phosphatase (IPP5)	0	DIRECT
Bactericidal permeability-increasing protein, BPI	0	DIRECT
Elafin-like	0	DIRECT
14-3-3 protein	0	DIRECT
AN1-like Zinc finger	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
Formate/glycerate dehydrogenases, NAD-domain	0	DIRECT
GAPDH-like	0	DIRECT
1,3-glucuronyltransferase	0	DIRECT
Chaperone J-domain	0	DIRECT
Phoshoinositide 3-kinase (PI3K) helical domain	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
ATP-dependent protease Lon (La), catalytic domain	0	DIRECT
UDP-glucose pyrophosphorylase	0	DIRECT
Biotin dependent carboxylase carboxyltransferase domain	0	DIRECT
Ras-binding domain, RBD	0	DIRECT
Acyl-CoA thioesterase	0	DIRECT
Myeloperoxidase-like	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
Acireductone dioxygenase	0	DIRECT
LacY-like proton/sugar symporter	0	DIRECT
Pancreatic carboxypeptidase, activation domain	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
HSP20	0	DIRECT
RNA-polymerase beta	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
HCDH C-domain-like	0	DIRECT
28-residue LRR	0	DIRECT
FtsH protease domain-like	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
MFPT repeat	0	DIRECT
Subtilases	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
MIR domain	0	DIRECT
Small-conductance potassium channel	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
Arfaptin, Rac-binding fragment	0	DIRECT
Glycerol kinase	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
L-aminoacid/polyamine oxidase	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
Acylamino-acid-releasing enzyme, C-terminal donain	0	DIRECT
Glycerophosphoryl diester phosphodiesterase	0	DIRECT
Methionine aminopeptidase, insert domain	0	DIRECT
Anticodon-binding domain	0	DIRECT
FF domain	0	DIRECT
Anticodon-binding domain of Class II aaRS	0	DIRECT
Arginine methyltransferase	0	DIRECT
PEP carboxykinase C-terminal domain	0	DIRECT
First domain of FERM	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Hormone receptor domain	0	DIRECT
ARID domain	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
La domain	0	DIRECT
Heme-dependent catalases	0	DIRECT
Epoxide hydrolase	0	DIRECT
Laminin G-like module	0	DIRECT
2Fe-2S ferredoxin domains from multidomain proteins	0	DIRECT
LDH N-terminal domain-like	0	DIRECT
Inositol polyphosphate kinase (IPK)	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Complement control module/SCR domain	0	DIRECT
Cell cycle control phosphatase, catalytic domain	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
Glutaminase	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Translational machinery components	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
acyl-CoA oxidase N-terminal domains	0	DIRECT
Mitochondrial carrier	0.0006952	DIRECT
BTB/POZ domain	0.03466	INHERITED FROM: early larval arrest || L1 arrest
UBC-related	0.4851	INHERITED FROM: late larval arrest
Ribonuclease PH domain 1-like	0.7123	INHERITED FROM: early larval arrest
Ribonuclease PH domain 2-like	0.7123	INHERITED FROM: early larval arrest
Canonical RBD	1	INHERITED FROM: late larval arrest

Trees by TreeVector

A presence/absence matrix is generated using protein domain architecture data for all genomes in SUPERFAMILY. The PAUP software is used to produce a single, large tree topology using heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as if individual trees had been produced. However, this data is extracted from the single large tree. This produces a higher quality topology than if the trees had been produced on their own, and allows the trees to be displayed instantly.

Supra-domains annotated to this WP term (SPWP level: Least Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Radical SAM enzymes	0	DIRECT
Cadherin-like	0	DIRECT
AN1-like Zinc finger	0	DIRECT
Hormone receptor domain	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
FF domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
Zn-binding ribosomal proteins	0	DIRECT
Tricorn protease domain 2	0	DIRECT
Phosphoenolpyruvate/pyruvate domain	0	DIRECT
Ribokinase-like	0	DIRECT
GroEL apical domain-like	0	DIRECT
ArfGap/RecO-like zinc finger	0	DIRECT
MIR domain	0	DIRECT
Hedgehog/intein (Hint) domain	0	DIRECT
ADP-ribosylation	0	DIRECT
LDH C-terminal domain-like	0	DIRECT
Galactose oxidase, central domain	0	DIRECT
Ribosomal protein L1	0	DIRECT
MgtE membrane domain-like	0	DIRECT
Ribosomal protein S10	0	DIRECT
Tubby C-terminal domain-like	0	DIRECT
Restriction endonuclease-like	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Chitinase insertion domain	0	DIRECT
Oxysterol-binding protein-like	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
PHM/PNGase F	0	DIRECT
PABC (PABP) domain	0	DIRECT
Phoshotransferase/anion transport protein	0	DIRECT
SAND domain-like	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
JAB1/MPN domain	0	DIRECT
FtsH protease domain-like	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
LysM domain	0	DIRECT
HSP20-like chaperones	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
Integrin alpha N-terminal domain	0	DIRECT
ThrRS/AlaRS common domain	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
MFPT repeat-like	0	DIRECT
Sec7 domain	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
PK beta-barrel domain-like	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Cystatin/monellin	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
R3H domain	0	DIRECT
eIF4e-like	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Tryptophan synthase beta subunit-like PLP-dependent enzymes	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
Doublecortin (DC)	0	DIRECT
Rap/Ran-GAP	0	DIRECT
Heme-dependent peroxidases	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
CBD9-like	0	DIRECT
GYF domain	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
Diaminopimelate epimerase-like	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Nucleoporin domain	0	DIRECT
Terpenoid cyclases/Protein prenyltransferases	0	DIRECT
PEP carboxykinase-like	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
Protease propeptides/inhibitors	0	DIRECT
Citrate synthase	0	DIRECT
GroEL equatorial domain-like	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
SPOC domain-like	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
L-aspartase-like	0	DIRECT
ARID-like	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
VPS9 domain	0	DIRECT
LEM domain	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Complement control module/SCR domain	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
FAD-binding/transporter-associated domain-like	0	DIRECT
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
Small-conductance potassium channel	0	DIRECT
Creatinase/prolidase N-terminal domain	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
HRDC-like	0	DIRECT
GAS2 domain-like	0	DIRECT
Acid phosphatase/Vanadium-dependent haloperoxidase	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
PEBP-like	0	DIRECT
Outer arm dynein light chain 1	0	DIRECT
2Fe-2S ferredoxin-like	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
beta-lactamase/transpeptidase-like	0	DIRECT
Elafin-like	0	DIRECT
Chaperone J-domain	0	DIRECT
Formate/glycerate dehydrogenase catalytic domain-like	0	DIRECT
WGR domain-like	0	DIRECT
alpha/beta knot	0	DIRECT
Arginase/deacetylase	0	DIRECT
Pentein	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
TGS-like	0	DIRECT
Annexin	0	DIRECT
Terpenoid synthases	0	DIRECT
14-3-3 protein	0	DIRECT
Carbohydrate phosphatase	0	DIRECT
Subtilisin-like	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Cytochrome c	0	DIRECT
Heme-dependent catalase-like	0	DIRECT
FAD-linked oxidases, C-terminal domain	0	DIRECT
PapD-like	0.0003687	DIRECT
Mitochondrial carrier	0.000643	DIRECT
POZ domain	0.004033	INHERITED FROM: L1 arrest || early larval arrest
Ribosomal protein S5 domain 2-like	0.199	INHERITED FROM: early larval arrest
Protein kinase-like (PK-like)	0.2773	INHERITED FROM: mid larval arrest
Quinoprotein alcohol dehydrogenase-like	0.3624	INHERITED FROM: mid larval arrest || L2 arrest
Translation proteins SH3-like domain	0.4029	INHERITED FROM: early larval arrest
WD40 repeat-like	0.5096	INHERITED FROM: late larval arrest || early larval arrest
UBC-like	0.5919	INHERITED FROM: late larval arrest
Ribonuclease PH domain 2-like	0.7219	INHERITED FROM: early larval arrest

Supra-domains annotated to this WP term (SPWP level: Least Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
50156,50044 50156 - PDZ domain-like 50044 - SH3-domain	0	DIRECT
81324,81296 81324 - Voltage-gated potassium channels 81296 - E set domains	0	DIRECT
48179,48179 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like	0	DIRECT
56176,55103 56176 - FAD-binding/transporter-associated domain-like 55103 - FAD-linked oxidases, C-terminal domain	0	DIRECT
161093,161093 161093 - MgtE membrane domain-like 161093 - MgtE membrane domain-like	0	DIRECT
48334,52540 48334 - DNA repair protein MutS, domain III 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
141739,141739 141739 - MFPT repeat-like 141739 - MFPT repeat-like	0	DIRECT
54495,46934 54495 - UBC-like 46934 - UBA-like	0	DIRECT
54695,81382 54695 - POZ domain 81382 - Skp1 dimerisation domain-like	0	DIRECT
51735,56327 51735 - NAD(P)-binding Rossmann-fold domains 56327 - LDH C-terminal domain-like	0	DIRECT
64356,49447 64356 - SNARE-like 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
56112,48371 56112 - Protein kinase-like (PK-like) 48371 - ARM repeat	0	DIRECT
52540,81271 52540 - P-loop containing nucleoside triphosphate hydrolases 81271 - TGS-like	0	DIRECT
57903,82199 57903 - FYVE/PHD zinc finger 82199 - SET domain	0	DIRECT
47473,51695 47473 - EF-hand 51695 - PLC-like phosphodiesterases	0	DIRECT
47741,56176 47741 - CO dehydrogenase ISP C-domain like 56176 - FAD-binding/transporter-associated domain-like	0	DIRECT
55486,57552 55486 - Metalloproteases ("zincins"), catalytic domain 57552 - Blood coagulation inhibitor (disintegrin)	0	DIRECT
52743,49785 52743 - Subtilisin-like 49785 - Galactose-binding domain-like	0	DIRECT
54211,55060 54211 - Ribosomal protein S5 domain 2-like 55060 - GHMP Kinase, C-terminal domain	0	DIRECT
49742,49742 49742 - PHM/PNGase F 49742 - PHM/PNGase F	0	DIRECT
55973,55973 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase	0	DIRECT
57362,57362 57362 - BPTI-like 57362 - BPTI-like	0	DIRECT
68923,53795 68923 - PEP carboxykinase N-terminal domain 53795 - PEP carboxykinase-like	0	DIRECT
50677,52374 50677 - ValRS/IleRS/LeuRS editing domain 52374 - Nucleotidylyl transferase	0	DIRECT
57196,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
52540,46785 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain	0	DIRECT
54001,49758 54001 - Cysteine proteinases 49758 - Calpain large subunit, middle domain (domain III)	0	DIRECT
57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain	0	DIRECT
57863,48403 57863 - ArfGap/RecO-like zinc finger 48403 - Ankyrin repeat	0	DIRECT
51971,54373 51971 - Nucleotide-binding domain 54373 - FAD-linked reductases, C-terminal domain	0	DIRECT
47769,47769 47769 - SAM/Pointed domain 47769 - SAM/Pointed domain	0	DIRECT
81383,52047 81383 - F-box domain 52047 - RNI-like	0	DIRECT
81698,81698 81698 - FF domain 81698 - FF domain	0	DIRECT
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like	0	DIRECT
51338,51556 51338 - Composite domain of metallo-dependent hydrolases 51556 - Metallo-dependent hydrolases	0	DIRECT
57414,57414 57414 - Hairpin loop containing domain-like 57414 - Hairpin loop containing domain-like	0	DIRECT
55486,50923 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain	0	DIRECT
51445,54556 51445 - (Trans)glycosidases 54556 - Chitinase insertion domain	0	DIRECT
49493,49493 49493 - HSP40/DnaJ peptide-binding domain 49493 - HSP40/DnaJ peptide-binding domain	0	DIRECT
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
48425,50729 48425 - Sec7 domain 50729 - PH domain-like	0	DIRECT
49313,49313 49313 - Cadherin-like 49313 - Cadherin-like	0	DIRECT
46785,46785 46785 - "Winged helix" DNA-binding domain 46785 - "Winged helix" DNA-binding domain	0	DIRECT
55326,56042 55326 - PurM N-terminal domain-like 56042 - PurM C-terminal domain-like	0	DIRECT
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat	0	DIRECT
47203,47203 47203 - Acyl-CoA dehydrogenase C-terminal domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like	0	DIRECT
81383,50978 81383 - F-box domain 50978 - WD40 repeat-like	0	DIRECT
52518,52518 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52518 - Thiamin diphosphate-binding fold (THDP-binding)	0	DIRECT
54897,53187 54897 - Protease propeptides/inhibitors 53187 - Zn-dependent exopeptidases	0	DIRECT
47587,56399 47587 - Domain of poly(ADP-ribose) polymerase 56399 - ADP-ribosylation	0	DIRECT
54534,54534 54534 - FKBP-like 54534 - FKBP-like	0	DIRECT
144232,82199 144232 - HIT/MYND zinc finger-like 82199 - SET domain	0	DIRECT
48403,52151 48403 - Ankyrin repeat 52151 - FabD/lysophospholipase-like	0	DIRECT
81324,53850 81324 - Voltage-gated potassium channels 53850 - Periplasmic binding protein-like II	0	DIRECT
74650,51445 74650 - Galactose mutarotase-like 51445 - (Trans)glycosidases	0	DIRECT
53187,55031 53187 - Zn-dependent exopeptidases 55031 - Bacterial exopeptidase dimerisation domain	0	DIRECT
47473,103506 47473 - EF-hand 103506 - Mitochondrial carrier	0	DIRECT
56601,48403 56601 - beta-lactamase/transpeptidase-like 48403 - Ankyrin repeat	0	DIRECT
54665,56003 54665 - CO dehydrogenase molybdoprotein N-domain-like 56003 - Molybdenum cofactor-binding domain	0	DIRECT
54897,52743 54897 - Protease propeptides/inhibitors 52743 - Subtilisin-like	0	DIRECT
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0	DIRECT
52283,51735 52283 - Formate/glycerate dehydrogenase catalytic domain-like 51735 - NAD(P)-binding Rossmann-fold domains	0	DIRECT
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
161111,160240 161111 - Cation efflux protein transmembrane domain-like 160240 - Cation efflux protein cytoplasmic domain-like	0	DIRECT
141673,50800 141673 - MOSC N-terminal domain-like 50800 - PK beta-barrel domain-like	0	DIRECT
57938,49493 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain	0	DIRECT
52540,140990 52540 - P-loop containing nucleoside triphosphate hydrolases 140990 - FtsH protease domain-like	0	DIRECT
54292,47741 54292 - 2Fe-2S ferredoxin-like 47741 - CO dehydrogenase ISP C-domain like	0	DIRECT
57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0	DIRECT
50044,52540 50044 - SH3-domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
57903,51197 57903 - FYVE/PHD zinc finger 51197 - Clavaminate synthase-like	0	DIRECT
55920,46785 55920 - Creatinase/aminopeptidase 46785 - "Winged helix" DNA-binding domain	0	DIRECT
81324,81327 81324 - Voltage-gated potassium channels 81327 - Small-conductance potassium channel	0	DIRECT
50978,50998 50978 - WD40 repeat-like 50998 - Quinoprotein alcohol dehydrogenase-like	0	DIRECT
57850,117839 57850 - RING/U-box 117839 - WWE domain	0	DIRECT
55394,55394 55394 - Bactericidal permeability-increasing protein, BPI 55394 - Bactericidal permeability-increasing protein, BPI	0	DIRECT
54211,55666 54211 - Ribosomal protein S5 domain 2-like 55666 - Ribonuclease PH domain 2-like	0.7219	INHERITED FROM: early larval arrest
54928,54928 54928 - RNA-binding domain, RBD 54928 - RNA-binding domain, RBD	1	INHERITED FROM: late larval arrest