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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

• Disease Ontology (DO) Ontology (DO)
  DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
  
• Human Phenotype (HP) Ontology (HP)
  HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
  
• Mouse Phenotype (MP) Ontology (MP)
  MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
  
• Worm Phenotype (WP) Ontology (WP)
  WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
  
• Yeast Phenotype (YP) Ontology (YP)
  Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
  
• Fly Phenotype (FP) Ontology (FP)
  FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
  
• Fly Anatomy (FA) Ontology (FA)
  FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
  
• Zebrafish Anatomy (ZA) Ontology (ZA)
  ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
  
• Xenopus Anatomy (XA) Ontology (XA)
  XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
  
• Arabidopsis Plant Ontology (AP) Ontology (AP)
  As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
  
• Enzyme Commission (EC) Ontology (EC)
  Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
  
• DrugBank ATC (DB) Ontology (DB)
  In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
  
• UniProtKB KeyWords (KW) Ontology (KW)
  Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
  
• UniProtKB UniPathway (UP) Ontology (UP)
  UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
  

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
  

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
  

Superfamily domains annotated to this WP term (SDWP level: Least Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Hormone receptor domain	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
Carbohydrate phosphatase	0	DIRECT
Oxysterol-binding protein-like	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
Acid phosphatase/Vanadium-dependent haloperoxidase	0	DIRECT
LDH C-terminal domain-like	0	DIRECT
PHM/PNGase F	0	DIRECT
SPOC domain-like	0	DIRECT
MFPT repeat-like	0	DIRECT
MgtE membrane domain-like	0	DIRECT
14-3-3 protein	0	DIRECT
Nucleoporin domain	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
Annexin	0	DIRECT
GYF domain	0	DIRECT
CBD9-like	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
TGS-like	0	DIRECT
Sec7 domain	0	DIRECT
LysM domain	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
GAS2 domain-like	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
ThrRS/AlaRS common domain	0	DIRECT
Restriction endonuclease-like	0	DIRECT
Cadherin-like	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Ribosomal protein S10	0	DIRECT
Complement control module/SCR domain	0	DIRECT
Rap/Ran-GAP	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Proton glutamate symport protein	0	DIRECT
R3H domain	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
PEBP-like	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Integrin alpha N-terminal domain	0	DIRECT
GroEL apical domain-like	0	DIRECT
eIF4e-like	0	DIRECT
Outer arm dynein light chain 1	0	DIRECT
FF domain	0	DIRECT
PEP carboxykinase-like	0	DIRECT
Cytochrome c	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
Protease propeptides/inhibitors	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
VPS9 domain	0	DIRECT
beta-lactamase/transpeptidase-like	0	DIRECT
PK beta-barrel domain-like	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
GroEL equatorial domain-like	0	DIRECT
FtsH protease domain-like	0	DIRECT
Citrate synthase	0	DIRECT
Creatinase/prolidase N-terminal domain	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
SAND domain-like	0	DIRECT
Ribosomal protein L1	0	DIRECT
ARID-like	0	DIRECT
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
Diaminopimelate epimerase-like	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
Hedgehog/intein (Hint) domain	0	DIRECT
Zn-binding ribosomal proteins	0	DIRECT
PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	DIRECT
Chaperone J-domain	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
AN1-like Zinc finger	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
Galactose oxidase, central domain	0	DIRECT
JAB1/MPN domain	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
Arginase/deacetylase	0	DIRECT
Terpenoid synthases	0	DIRECT
Ribokinase-like	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
Elafin-like	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
Chitinase insertion domain	0	DIRECT
Cystatin/monellin	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
Heme-dependent catalase-like	0	DIRECT
Tricorn protease domain 2	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
HSP20-like chaperones	0	DIRECT
Phosphoenolpyruvate/pyruvate domain	0	DIRECT
Heme-dependent peroxidases	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
ADP-ribosylation	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Small-conductance potassium channel	0	DIRECT
alpha/beta knot	0	DIRECT
Formate/glycerate dehydrogenase catalytic domain-like	0	DIRECT
LEM domain	0	DIRECT
MIR domain	0	DIRECT
ArfGap/RecO-like zinc finger	0	DIRECT
Tubby C-terminal domain-like	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
Phoshotransferase/anion transport protein	0	DIRECT
Subtilisin-like	0	DIRECT
Doublecortin (DC)	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
PABC (PABP) domain	0	DIRECT
2Fe-2S ferredoxin-like	0	DIRECT
Pentein	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
Terpenoid cyclases/Protein prenyltransferases	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
L-aspartase-like	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
Tryptophan synthase beta subunit-like PLP-dependent enzymes	0	DIRECT
WGR domain-like	0	DIRECT
PapD-like	0.00007806	DIRECT
Mitochondrial carrier	0.0008919	DIRECT
POZ domain	0.002523	INHERITED FROM: early larval arrest || L1 arrest
Protein kinase-like (PK-like)	0.09311	INHERITED FROM: mid larval arrest
Ribosomal protein S5 domain 2-like	0.2077	INHERITED FROM: early larval arrest
Quinoprotein alcohol dehydrogenase-like	0.3988	INHERITED FROM: L2 arrest || mid larval arrest
Translation proteins SH3-like domain	0.4393	INHERITED FROM: early larval arrest
UBC-like	0.6385	INHERITED FROM: late larval arrest
WD40 repeat-like	0.7414	INHERITED FROM: early larval arrest || late larval arrest
Ribonuclease PH domain 2-like	0.757	INHERITED FROM: early larval arrest

Family domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Clathrin coat assembly domain	0	DIRECT
Oxysterol-binding protein	0	DIRECT
Peptidylglycine alpha-hydroxylating monooxygenase, PHM	0	DIRECT
Translation initiation factor eIF4e	0	DIRECT
Chaperone J-domain	0	DIRECT
Hydantoinase (dihydropyrimidinase)	0	DIRECT
YihX-like	0	DIRECT
Methionine aminopeptidase, insert domain	0	DIRECT
Chitinase insertion domain	0	DIRECT
Small-conductance potassium channel	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
Acireductone dioxygenase	0	DIRECT
28-residue LRR	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
Doublecortin (DC)	0	DIRECT
Translational machinery components	0	DIRECT
GAS2 domain	0	DIRECT
COMT-like	0	DIRECT
SWIRM domain	0	DIRECT
Acyl-CoA thioesterase	0	DIRECT
MFPT repeat	0	DIRECT
Arylsulfatase	0	DIRECT
LysM domain	0	DIRECT
DPP6 catalytic domain-like	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Brix domain	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Protein prenyltransferases	0	DIRECT
acyl-CoA oxidase C-terminal domains	0	DIRECT
Ribosomal protein L1	0	DIRECT
VHS domain	0	DIRECT
Subtilases	0	DIRECT
Poly(ADP-ribose) polymerase, C-terminal domain	0	DIRECT
Poly(A) polymerase, PAP, C-terminal domain	0	DIRECT
Acylamino-acid-releasing enzyme, C-terminal donain	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
Double-stranded RNA-binding domain (dsRBD)	0	DIRECT
Cell cycle control phosphatase, catalytic domain	0	DIRECT
Inositol polyphosphate kinase (IPK)	0	DIRECT
GAPDH-like	0	DIRECT
14-3-3 protein	0	DIRECT
Hsp90 middle domain	0	DIRECT
Phosphatidylethanolamine binding protein	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
Choline kinase	0	DIRECT
Laminin G-like module	0	DIRECT
DEP domain	0	DIRECT
Ribokinase-like	0	DIRECT
Adenosine/AMP deaminase	0	DIRECT
D-aminoacid oxidase, N-terminal domain	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
Glycogenin	0	DIRECT
L-aminoacid/polyamine oxidase	0	DIRECT
Group II chaperonin (CCT, TRIC), ATPase domain	0	DIRECT
NHL repeat	0	DIRECT
Hedgehog C-terminal (Hog) autoprocessing domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Formate/glycerate dehydrogenases, NAD-domain	0	DIRECT
Phoshoinositide 3-kinase (PI3K) helical domain	0	DIRECT
Sec7 domain	0	DIRECT
IF2B-like	0	DIRECT
AN1-like Zinc finger	0	DIRECT
Calpain large subunit, catalytic domain (domain II)	0	DIRECT
Citrate synthase	0	DIRECT
RhoGDI-like	0	DIRECT
HSP20	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
Tetraspanin	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
PDI-like	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
Histone deacetylase, HDAC	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
Sec63 C-terminal domain-like	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
HD domain	0	DIRECT
RNA-polymerase beta-prime	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
Cadherin	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Epoxide hydrolase	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
PEP carboxykinase C-terminal domain	0	DIRECT
Poly(A) polymerase, PAP, N-terminal domain	0	DIRECT
2Fe-2S ferredoxin domains from multidomain proteins	0	DIRECT
Ribosomal protein S10	0	DIRECT
Myeloperoxidase-like	0	DIRECT
Heme-dependent catalases	0	DIRECT
Anticodon-binding domain	0	DIRECT
XPF/Rad1/Mus81 nuclease	0	DIRECT
Bactericidal permeability-increasing protein, BPI	0	DIRECT
LacY-like proton/sugar symporter	0	DIRECT
YicI catalytic domain-like	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Gamma-glutamyltranspeptidase-like	0	DIRECT
Hexokinase	0	DIRECT
Proprotein convertase P-domain	0	DIRECT
Group II chaperonin (CCT, TRIC), apical domain	0	DIRECT
Annexin	0	DIRECT
Pyk2-associated protein beta ARF-GAP domain	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
LDH N-terminal domain-like	0	DIRECT
First domain of FERM	0	DIRECT
NOL1/NOP2/sun	0	DIRECT
WGR domain	0	DIRECT
1,3-glucuronyltransferase	0	DIRECT
Glutaminase	0	DIRECT
Biotin dependent carboxylase carboxyltransferase domain	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Serum paraoxonase/arylesterase 1, PON1	0	DIRECT
Glycerol kinase	0	DIRECT
Pancreatic carboxypeptidase, activation domain	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
Tryptophan synthase beta subunit-like PLP-dependent enzymes	0	DIRECT
Rap/Ran-GAP	0	DIRECT
RNA-polymerase beta	0	DIRECT
Anticodon-binding domain of Class II aaRS	0	DIRECT
Lactate & malate dehydrogenases, C-terminal domain	0	DIRECT
D-aminoacid oxidase-like	0	DIRECT
Sec63 N-terminal domain	0	DIRECT
AMPK-beta glycogen binding domain-like	0	DIRECT
Arginine methyltransferase	0	DIRECT
LEM domain	0	DIRECT
Poly(A) polymerase, PAP, middle domain	0	DIRECT
SAND domain	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Hormone receptor domain	0	DIRECT
MIR domain	0	DIRECT
Complement control module/SCR domain	0	DIRECT
Inositol polyphosphate 5-phosphatase (IPP5)	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Type II chitinase	0	DIRECT
beta-Lactamase/D-ala carboxypeptidase	0	DIRECT
HCDH C-domain-like	0	DIRECT
SAM (sterile alpha motif) domain	0	DIRECT
Myotubularin-like phosphatases	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
PABC (PABP) domain	0	DIRECT
GYF domain	0	DIRECT
La domain	0	DIRECT
DEATH domain, DD	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
Glycerophosphoryl diester phosphodiesterase	0	DIRECT
FF domain	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
CoA-binding domain	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
PhzC/PhzF-like	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
UDP-glucose pyrophosphorylase	0	DIRECT
FtsH protease domain-like	0	DIRECT
U-box	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
Elafin-like	0	DIRECT
Inositol monophosphatase/fructose-1,6-bisphosphatase-like	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
ATP-dependent protease Lon (La), catalytic domain	0	DIRECT
Cytoplasmic domain of inward rectifier potassium channel	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
Paired domain	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
CO dehydrogenase flavoprotein N-terminal domain-like	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
PUA domain	0	DIRECT
acyl-CoA oxidase N-terminal domains	0	DIRECT
ARID domain	0	DIRECT
Arfaptin, Rac-binding fragment	0	DIRECT
MSP-like	0.0001977	DIRECT
Mitochondrial carrier	0.0008082	DIRECT
BTB/POZ domain	0.09277	INHERITED FROM: early larval arrest || L1 arrest
UBC-related	0.508	INHERITED FROM: late larval arrest
Ribonuclease PH domain 2-like	0.7323	INHERITED FROM: early larval arrest
Ribonuclease PH domain 1-like	0.7323	INHERITED FROM: early larval arrest
Canonical RBD	1	INHERITED FROM: late larval arrest

Trees by TreeVector

A presence/absence matrix is generated using protein domain architecture data for all genomes in SUPERFAMILY. The PAUP software is used to produce a single, large tree topology using heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as if individual trees had been produced. However, this data is extracted from the single large tree. This produces a higher quality topology than if the trees had been produced on their own, and allows the trees to be displayed instantly.

Supra-domains annotated to this WP term (SPWP level: Least Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Outer arm dynein light chain 1	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
Tryptophan synthase beta subunit-like PLP-dependent enzymes	0	DIRECT
MFPT repeat-like	0	DIRECT
ADP-ribosylation	0	DIRECT
GroEL equatorial domain-like	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
beta-lactamase/transpeptidase-like	0	DIRECT
ArfGap/RecO-like zinc finger	0	DIRECT
Restriction endonuclease-like	0	DIRECT
eIF4e-like	0	DIRECT
Chaperone J-domain	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
Pentein	0	DIRECT
Subtilisin-like	0	DIRECT
MIR domain	0	DIRECT
Ribosomal protein L1	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
PABC (PABP) domain	0	DIRECT
Cadherin-like	0	DIRECT
Chitinase insertion domain	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
Acid phosphatase/Vanadium-dependent haloperoxidase	0	DIRECT
LysM domain	0	DIRECT
CBD9-like	0	DIRECT
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
alpha/beta knot	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Terpenoid cyclases/Protein prenyltransferases	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
LEM domain	0	DIRECT
Citrate synthase	0	DIRECT
Heme-dependent peroxidases	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
Small-conductance potassium channel	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
Phosphoenolpyruvate/pyruvate domain	0	DIRECT
Rap/Ran-GAP	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
MgtE membrane domain-like	0	DIRECT
FtsH protease domain-like	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
Tubby C-terminal domain-like	0	DIRECT
Annexin	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
R3H domain	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
2Fe-2S ferredoxin-like	0	DIRECT
Creatinase/prolidase N-terminal domain	0	DIRECT
Nucleoporin domain	0	DIRECT
PK beta-barrel domain-like	0	DIRECT
SAND domain-like	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
Oxysterol-binding protein-like	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Arginase/deacetylase	0	DIRECT
14-3-3 protein	0	DIRECT
Galactose oxidase, central domain	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Ribokinase-like	0	DIRECT
Cystatin/monellin	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
Protease propeptides/inhibitors	0	DIRECT
Phoshotransferase/anion transport protein	0	DIRECT
Carbohydrate phosphatase	0	DIRECT
GYF domain	0	DIRECT
PEP carboxykinase-like	0	DIRECT
Ribosomal protein S10	0	DIRECT
Zn-binding ribosomal proteins	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
Diaminopimelate epimerase-like	0	DIRECT
FF domain	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Formate/glycerate dehydrogenase catalytic domain-like	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
Hormone receptor domain	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Elafin-like	0	DIRECT
VPS9 domain	0	DIRECT
Cytochrome c	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
GroEL apical domain-like	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
JAB1/MPN domain	0	DIRECT
ThrRS/AlaRS common domain	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
Tricorn protease domain 2	0	DIRECT
SPOC domain-like	0	DIRECT
ARID-like	0	DIRECT
Terpenoid synthases	0	DIRECT
Complement control module/SCR domain	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
TGS-like	0	DIRECT
Sec7 domain	0	DIRECT
LDH C-terminal domain-like	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	DIRECT
AN1-like Zinc finger	0	DIRECT
HSP20-like chaperones	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
Integrin alpha N-terminal domain	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
PEBP-like	0	DIRECT
Doublecortin (DC)	0	DIRECT
PHM/PNGase F	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
Hedgehog/intein (Hint) domain	0	DIRECT
Heme-dependent catalase-like	0	DIRECT
L-aspartase-like	0	DIRECT
GAS2 domain-like	0	DIRECT
WGR domain-like	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
PapD-like	0.00006353	DIRECT
Mitochondrial carrier	0.0007372	DIRECT
POZ domain	0.00211	INHERITED FROM: L1 arrest || early larval arrest
Protein kinase-like (PK-like)	0.08364	INHERITED FROM: mid larval arrest
Ribosomal protein S5 domain 2-like	0.1911	INHERITED FROM: early larval arrest
Quinoprotein alcohol dehydrogenase-like	0.3775	INHERITED FROM: mid larval arrest || L2 arrest
Translation proteins SH3-like domain	0.4172	INHERITED FROM: early larval arrest
UBC-like	0.6165	INHERITED FROM: late larval arrest
WD40 repeat-like	0.7216	INHERITED FROM: early larval arrest || late larval arrest
Ribonuclease PH domain 2-like	0.738	INHERITED FROM: early larval arrest

Supra-domains annotated to this WP term (SPWP level: Least Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
55486,57552 55486 - Metalloproteases ("zincins"), catalytic domain 57552 - Blood coagulation inhibitor (disintegrin)	0	DIRECT
141673,50800 141673 - MOSC N-terminal domain-like 50800 - PK beta-barrel domain-like	0	DIRECT
54897,53187 54897 - Protease propeptides/inhibitors 53187 - Zn-dependent exopeptidases	0	DIRECT
141739,141739 141739 - MFPT repeat-like 141739 - MFPT repeat-like	0	DIRECT
53187,55031 53187 - Zn-dependent exopeptidases 55031 - Bacterial exopeptidase dimerisation domain	0	DIRECT
57414,57414 57414 - Hairpin loop containing domain-like 57414 - Hairpin loop containing domain-like	0	DIRECT
81383,52047 81383 - F-box domain 52047 - RNI-like	0	DIRECT
55486,50923 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain	0	DIRECT
47741,56176 47741 - CO dehydrogenase ISP C-domain like 56176 - FAD-binding/transporter-associated domain-like	0	DIRECT
81631,55003 81631 - PAP/OAS1 substrate-binding domain 55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	DIRECT
57756,50630 57756 - Retrovirus zinc finger-like domains 50630 - Acid proteases	0	DIRECT
53474,53474 53474 - alpha/beta-Hydrolases 53474 - alpha/beta-Hydrolases	0	DIRECT
48403,52151 48403 - Ankyrin repeat 52151 - FabD/lysophospholipase-like	0	DIRECT
101690,53098 101690 - PAZ domain 53098 - Ribonuclease H-like	0	DIRECT
48334,52540 48334 - DNA repair protein MutS, domain III 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like	0	DIRECT
51971,54373 51971 - Nucleotide-binding domain 54373 - FAD-linked reductases, C-terminal domain	0	DIRECT
161111,160240 161111 - Cation efflux protein transmembrane domain-like 160240 - Cation efflux protein cytoplasmic domain-like	0	DIRECT
51735,56327 51735 - NAD(P)-binding Rossmann-fold domains 56327 - LDH C-terminal domain-like	0	DIRECT
56601,48403 56601 - beta-lactamase/transpeptidase-like 48403 - Ankyrin repeat	0	DIRECT
54495,46934 54495 - UBC-like 46934 - UBA-like	0	DIRECT
54001,49758 54001 - Cysteine proteinases 49758 - Calpain large subunit, middle domain (domain III)	0	DIRECT
52518,52518 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52518 - Thiamin diphosphate-binding fold (THDP-binding)	0	DIRECT
57863,48403 57863 - ArfGap/RecO-like zinc finger 48403 - Ankyrin repeat	0	DIRECT
52540,46785 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain	0	DIRECT
57903,82199 57903 - FYVE/PHD zinc finger 82199 - SET domain	0	DIRECT
55326,56042 55326 - PurM N-terminal domain-like 56042 - PurM C-terminal domain-like	0	DIRECT
51735,50129 51735 - NAD(P)-binding Rossmann-fold domains 50129 - GroES-like	0	DIRECT
54695,81382 54695 - POZ domain 81382 - Skp1 dimerisation domain-like	0	DIRECT
64356,49447 64356 - SNARE-like 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
81324,53850 81324 - Voltage-gated potassium channels 53850 - Periplasmic binding protein-like II	0	DIRECT
54665,56003 54665 - CO dehydrogenase molybdoprotein N-domain-like 56003 - Molybdenum cofactor-binding domain	0	DIRECT
56112,48371 56112 - Protein kinase-like (PK-like) 48371 - ARM repeat	0	DIRECT
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0	DIRECT
81698,81698 81698 - FF domain 81698 - FF domain	0	DIRECT
57362,57362 57362 - BPTI-like 57362 - BPTI-like	0	DIRECT
57938,49493 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain	0	DIRECT
161093,161093 161093 - MgtE membrane domain-like 161093 - MgtE membrane domain-like	0	DIRECT
47473,51695 47473 - EF-hand 51695 - PLC-like phosphodiesterases	0	DIRECT
54292,47741 54292 - 2Fe-2S ferredoxin-like 47741 - CO dehydrogenase ISP C-domain like	0	DIRECT
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat	0	DIRECT
52283,51735 52283 - Formate/glycerate dehydrogenase catalytic domain-like 51735 - NAD(P)-binding Rossmann-fold domains	0	DIRECT
55973,55973 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase	0	DIRECT
81383,50978 81383 - F-box domain 50978 - WD40 repeat-like	0	DIRECT
68923,53795 68923 - PEP carboxykinase N-terminal domain 53795 - PEP carboxykinase-like	0	DIRECT
57850,117839 57850 - RING/U-box 117839 - WWE domain	0	DIRECT
49313,49313 49313 - Cadherin-like 49313 - Cadherin-like	0	DIRECT
54534,54534 54534 - FKBP-like 54534 - FKBP-like	0	DIRECT
144232,82199 144232 - HIT/MYND zinc finger-like 82199 - SET domain	0	DIRECT
50044,52540 50044 - SH3-domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
49742,49742 49742 - PHM/PNGase F 49742 - PHM/PNGase F	0	DIRECT
52540,81271 52540 - P-loop containing nucleoside triphosphate hydrolases 81271 - TGS-like	0	DIRECT
50156,50044 50156 - PDZ domain-like 50044 - SH3-domain	0	DIRECT
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
55394,55394 55394 - Bactericidal permeability-increasing protein, BPI 55394 - Bactericidal permeability-increasing protein, BPI	0	DIRECT
54211,55060 54211 - Ribosomal protein S5 domain 2-like 55060 - GHMP Kinase, C-terminal domain	0	DIRECT
51445,51445 51445 - (Trans)glycosidases 51445 - (Trans)glycosidases	0	DIRECT
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
47769,47769 47769 - SAM/Pointed domain 47769 - SAM/Pointed domain	0	DIRECT
81324,81327 81324 - Voltage-gated potassium channels 81327 - Small-conductance potassium channel	0	DIRECT
46785,46785 46785 - "Winged helix" DNA-binding domain 46785 - "Winged helix" DNA-binding domain	0	DIRECT
54897,52743 54897 - Protease propeptides/inhibitors 52743 - Subtilisin-like	0	DIRECT
47473,103506 47473 - EF-hand 103506 - Mitochondrial carrier	0	DIRECT
52540,140990 52540 - P-loop containing nucleoside triphosphate hydrolases 140990 - FtsH protease domain-like	0	DIRECT
55920,46785 55920 - Creatinase/aminopeptidase 46785 - "Winged helix" DNA-binding domain	0	DIRECT
49493,49493 49493 - HSP40/DnaJ peptide-binding domain 49493 - HSP40/DnaJ peptide-binding domain	0	DIRECT
74650,51445 74650 - Galactose mutarotase-like 51445 - (Trans)glycosidases	0	DIRECT
47587,56399 47587 - Domain of poly(ADP-ribose) polymerase 56399 - ADP-ribosylation	0	DIRECT
50677,52374 50677 - ValRS/IleRS/LeuRS editing domain 52374 - Nucleotidylyl transferase	0	DIRECT
81324,81296 81324 - Voltage-gated potassium channels 81296 - E set domains	0	DIRECT
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
51445,54556 51445 - (Trans)glycosidases 54556 - Chitinase insertion domain	0	DIRECT
50978,50998 50978 - WD40 repeat-like 50998 - Quinoprotein alcohol dehydrogenase-like	0	DIRECT
51338,51556 51338 - Composite domain of metallo-dependent hydrolases 51556 - Metallo-dependent hydrolases	0	DIRECT
48425,50729 48425 - Sec7 domain 50729 - PH domain-like	0	DIRECT
52743,49785 52743 - Subtilisin-like 49785 - Galactose-binding domain-like	0	DIRECT
57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0	DIRECT
103473,103473 103473 - MFS general substrate transporter 103473 - MFS general substrate transporter	0	DIRECT
54768,54768 54768 - dsRNA-binding domain-like 54768 - dsRNA-binding domain-like	0	DIRECT
57196,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
47203,47203 47203 - Acyl-CoA dehydrogenase C-terminal domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like	0	DIRECT
57903,51197 57903 - FYVE/PHD zinc finger 51197 - Clavaminate synthase-like	0	DIRECT
57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain	0	DIRECT
48179,48179 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like	0	DIRECT
54211,55666 54211 - Ribosomal protein S5 domain 2-like 55666 - Ribonuclease PH domain 2-like	0.738	INHERITED FROM: early larval arrest
54928,54928 54928 - RNA-binding domain, RBD 54928 - RNA-binding domain, RBD	1	INHERITED FROM: late larval arrest