•  SEARCH

  • Keyword search
  • Sequence search
• 
  

•  BROWSE

  •   Organisms
  • Taxonomy
  • Statistics
  •   SCOP
  • Hierarchy
  •   Ontologies
  • GO
  • EC
  • Phenotype
• 
  

•  TOOLS

  • Compare genomes
  • Phylogenetic trees
  • Web services
  • Downloads
• 
  

•  ABOUT

  • Description
  • Publications
  • Documentation
• 
  

•  HELP

  • User support
  • Contact us
  • Email list
  • Sitemap

Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

• Disease Ontology (DO) Ontology (DO)
  DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
  
• Human Phenotype (HP) Ontology (HP)
  HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
  
• Mouse Phenotype (MP) Ontology (MP)
  MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
  
• Worm Phenotype (WP) Ontology (WP)
  WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
  
• Yeast Phenotype (YP) Ontology (YP)
  Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
  
• Fly Phenotype (FP) Ontology (FP)
  FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
  
• Fly Anatomy (FA) Ontology (FA)
  FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
  
• Zebrafish Anatomy (ZA) Ontology (ZA)
  ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
  
• Xenopus Anatomy (XA) Ontology (XA)
  XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
  
• Arabidopsis Plant Ontology (AP) Ontology (AP)
  As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
  
• Enzyme Commission (EC) Ontology (EC)
  Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
  
• DrugBank ATC (DB) Ontology (DB)
  In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
  
• UniProtKB KeyWords (KW) Ontology (KW)
  Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
  
• UniProtKB UniPathway (UP) Ontology (UP)
  UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
  

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
  

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
  

Superfamily domains annotated to this WP term (SDWP level: Least Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Doublecortin (DC)	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
FF domain	0	DIRECT
JAB1/MPN domain	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
ARID-like	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
Arginase/deacetylase	0	DIRECT
Tubby C-terminal domain-like	0	DIRECT
Annexin	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Phosphoenolpyruvate/pyruvate domain	0	DIRECT
FtsH protease domain-like	0	DIRECT
FAD-linked oxidases, C-terminal domain	0	DIRECT
alpha/beta knot	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
Formate/glycerate dehydrogenase catalytic domain-like	0	DIRECT
PK beta-barrel domain-like	0	DIRECT
eIF4e-like	0	DIRECT
Acid phosphatase/Vanadium-dependent haloperoxidase	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
Pentein	0	DIRECT
Elafin-like	0	DIRECT
ArfGap/RecO-like zinc finger	0	DIRECT
Cytochrome c	0	DIRECT
2Fe-2S ferredoxin-like	0	DIRECT
Outer arm dynein light chain 1	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
Tryptophan synthase beta subunit-like PLP-dependent enzymes	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
GroEL equatorial domain-like	0	DIRECT
Proton glutamate symport protein	0	DIRECT
MIR domain	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
WGR domain-like	0	DIRECT
Diaminopimelate epimerase-like	0	DIRECT
FAD-binding/transporter-associated domain-like	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
Rap/Ran-GAP	0	DIRECT
Carbohydrate phosphatase	0	DIRECT
LDH C-terminal domain-like	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
LEM domain	0	DIRECT
Citrate synthase	0	DIRECT
MgtE membrane domain-like	0	DIRECT
ADP-ribosylation	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
Terpenoid cyclases/Protein prenyltransferases	0	DIRECT
Hedgehog/intein (Hint) domain	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
CBD9-like	0	DIRECT
Chaperone J-domain	0	DIRECT
PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	DIRECT
Hormone receptor domain	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
Heme-dependent catalase-like	0	DIRECT
Phoshotransferase/anion transport protein	0	DIRECT
HSP20-like chaperones	0	DIRECT
14-3-3 protein	0	DIRECT
Complement control module/SCR domain	0	DIRECT
Radical SAM enzymes	0	DIRECT
VPS9 domain	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Oxysterol-binding protein-like	0	DIRECT
Cystatin/monellin	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
Small-conductance potassium channel	0	DIRECT
GYF domain	0	DIRECT
LysM domain	0	DIRECT
Integrin alpha N-terminal domain	0	DIRECT
Ribosomal protein L1	0	DIRECT
L-aspartase-like	0	DIRECT
Terpenoid synthases	0	DIRECT
Cadherin-like	0	DIRECT
PEBP-like	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
beta-lactamase/transpeptidase-like	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
MFPT repeat-like	0	DIRECT
ThrRS/AlaRS common domain	0	DIRECT
Creatinase/prolidase N-terminal domain	0	DIRECT
Ribokinase-like	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Protease propeptides/inhibitors	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
AN1-like Zinc finger	0	DIRECT
Subtilisin-like	0	DIRECT
SPOC domain-like	0	DIRECT
Chitinase insertion domain	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Galactose oxidase, central domain	0	DIRECT
Heme-dependent peroxidases	0	DIRECT
SAND domain-like	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Nucleoporin domain	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
GroEL apical domain-like	0	DIRECT
PABC (PABP) domain	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
Restriction endonuclease-like	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
TGS-like	0	DIRECT
Sec7 domain	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
GAS2 domain-like	0	DIRECT
HRDC-like	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
Zn-binding ribosomal proteins	0	DIRECT
PEP carboxykinase-like	0	DIRECT
PHM/PNGase F	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Tricorn protease domain 2	0	DIRECT
Ribosomal protein S10	0	DIRECT
R3H domain	0	DIRECT
PapD-like	0.0004433	DIRECT
Mitochondrial carrier	0.0007712	DIRECT
POZ domain	0.004711	INHERITED FROM: L1 arrest || early larval arrest
Ribosomal protein S5 domain 2-like	0.2149	INHERITED FROM: early larval arrest
Protein kinase-like (PK-like)	0.3023	INHERITED FROM: mid larval arrest
Quinoprotein alcohol dehydrogenase-like	0.383	INHERITED FROM: mid larval arrest || L2 arrest
Translation proteins SH3-like domain	0.4241	INHERITED FROM: early larval arrest
WD40 repeat-like	0.5308	INHERITED FROM: late larval arrest || early larval arrest
UBC-like	0.6141	INHERITED FROM: late larval arrest
Ribonuclease PH domain 2-like	0.7424	INHERITED FROM: early larval arrest

Family domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Chitinase insertion domain	0	DIRECT
Pyk2-associated protein beta ARF-GAP domain	0	DIRECT
GAPDH-like	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Ras-binding domain, RBD	0	DIRECT
Myeloperoxidase-like	0	DIRECT
PDI-like	0	DIRECT
D-aminoacid oxidase-like	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
CAT-like	0	DIRECT
2Fe-2S ferredoxin domains from multidomain proteins	0	DIRECT
PABC (PABP) domain	0	DIRECT
MIR domain	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Ribosomal protein L1	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
DPP6 catalytic domain-like	0	DIRECT
Cell cycle control phosphatase, catalytic domain	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
PEP carboxykinase C-terminal domain	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
La domain	0	DIRECT
Pancreatic carboxypeptidase, activation domain	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Inositol polyphosphate 5-phosphatase (IPP5)	0	DIRECT
Type II chitinase	0	DIRECT
Annexin	0	DIRECT
Brix domain	0	DIRECT
Anticodon-binding domain	0	DIRECT
Citrate synthase	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
Cytoplasmic domain of inward rectifier potassium channel	0	DIRECT
Heme-dependent catalases	0	DIRECT
Hydantoinase (dihydropyrimidinase)	0	DIRECT
RhoGDI-like	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
WGR domain	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
SWIRM domain	0	DIRECT
First domain of FERM	0	DIRECT
FF domain	0	DIRECT
Ribokinase-like	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Ribosomal protein S10	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
Tryptophan synthase beta subunit-like PLP-dependent enzymes	0	DIRECT
ATP-dependent protease Lon (La), catalytic domain	0	DIRECT
Acylamino-acid-releasing enzyme, C-terminal donain	0	DIRECT
Hsp90 middle domain	0	DIRECT
Proton glutamate symport protein	0	DIRECT
ARID domain	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Inositol monophosphatase/fructose-1,6-bisphosphatase-like	0	DIRECT
Small-conductance potassium channel	0	DIRECT
28-residue LRR	0	DIRECT
Chaperone J-domain	0	DIRECT
XPF/Rad1/Mus81 nuclease	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Sec63 N-terminal domain	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
Lactate & malate dehydrogenases, C-terminal domain	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
Translation initiation factor eIF4e	0	DIRECT
Group II chaperonin (CCT, TRIC), apical domain	0	DIRECT
Myotubularin-like phosphatases	0	DIRECT
COMT-like	0	DIRECT
Hexokinase	0	DIRECT
Poly(A) polymerase, PAP, middle domain	0	DIRECT
HSP20	0	DIRECT
Proprotein convertase P-domain	0	DIRECT
PUA domain	0	DIRECT
U-box	0	DIRECT
Tetraspanin	0	DIRECT
Subtilases	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
Doublecortin (DC)	0	DIRECT
Adenosine/AMP deaminase	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Methionine aminopeptidase, insert domain	0	DIRECT
Vertebrate phospholipase A2	0	DIRECT
acyl-CoA oxidase C-terminal domains	0	DIRECT
Rap/Ran-GAP	0	DIRECT
GAS2 domain	0	DIRECT
Glycogenin	0	DIRECT
D-aminoacid oxidase, N-terminal domain	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
NOL1/NOP2/sun	0	DIRECT
RNA-polymerase beta	0	DIRECT
Protein prenyltransferases	0	DIRECT
14-3-3 protein	0	DIRECT
beta-Lactamase/D-ala carboxypeptidase	0	DIRECT
Biotin dependent carboxylase carboxyltransferase domain	0	DIRECT
Calpain large subunit, catalytic domain (domain II)	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
GYF domain	0	DIRECT
Epoxide hydrolase	0	DIRECT
Acireductone dioxygenase	0	DIRECT
PhzC/PhzF-like	0	DIRECT
LysM domain	0	DIRECT
Cadherin	0	DIRECT
MFPT repeat	0	DIRECT
Sec7 domain	0	DIRECT
Acyl-CoA thioesterase	0	DIRECT
Phoshoinositide 3-kinase (PI3K) helical domain	0	DIRECT
Histone deacetylase, HDAC	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
Clathrin coat assembly domain	0	DIRECT
Paired domain	0	DIRECT
Poly(ADP-ribose) polymerase, C-terminal domain	0	DIRECT
Laminin G-like module	0	DIRECT
LEM domain	0	DIRECT
DEP domain	0	DIRECT
acyl-CoA oxidase N-terminal domains	0	DIRECT
L-aminoacid/polyamine oxidase	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
NTF2-like	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
1,3-glucuronyltransferase	0	DIRECT
RNA-polymerase beta-prime	0	DIRECT
LacY-like proton/sugar symporter	0	DIRECT
DEATH domain, DD	0	DIRECT
YicI catalytic domain-like	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
Inositol polyphosphate kinase (IPK)	0	DIRECT
Phosphatidylethanolamine binding protein	0	DIRECT
CO dehydrogenase flavoprotein N-terminal domain-like	0	DIRECT
IF2B-like	0	DIRECT
Sec63 C-terminal domain-like	0	DIRECT
VHS domain	0	DIRECT
Serum paraoxonase/arylesterase 1, PON1	0	DIRECT
AMPK-beta glycogen binding domain-like	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
Formate/glycerate dehydrogenases, NAD-domain	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Group II chaperonin (CCT, TRIC), ATPase domain	0	DIRECT
FtsH protease domain-like	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
Translational machinery components	0	DIRECT
LDH N-terminal domain-like	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
HCDH C-domain-like	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
Peptidylglycine alpha-hydroxylating monooxygenase, PHM	0	DIRECT
Choline kinase	0	DIRECT
Elafin-like	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
Glycerol kinase	0	DIRECT
Glutaminase	0	DIRECT
Bactericidal permeability-increasing protein, BPI	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Complement control module/SCR domain	0	DIRECT
Oxysterol-binding protein	0	DIRECT
Hedgehog C-terminal (Hog) autoprocessing domain	0	DIRECT
Arylsulfatase	0	DIRECT
YihX-like	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
Glycerophosphoryl diester phosphodiesterase	0	DIRECT
SAM (sterile alpha motif) domain	0	DIRECT
AN1-like Zinc finger	0	DIRECT
Gamma-glutamyltranspeptidase-like	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
CoA-binding domain	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
UDP-glucose pyrophosphorylase	0	DIRECT
Poly(A) polymerase, PAP, C-terminal domain	0	DIRECT
HD domain	0	DIRECT
SAND domain	0	DIRECT
Hormone receptor domain	0	DIRECT
NHL repeat	0	DIRECT
Anticodon-binding domain of Class II aaRS	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
Poly(A) polymerase, PAP, N-terminal domain	0	DIRECT
Arfaptin, Rac-binding fragment	0	DIRECT
Arginine methyltransferase	0	DIRECT
Mitochondrial carrier	0.0006895	DIRECT
BTB/POZ domain	0.03435	INHERITED FROM: L1 arrest || early larval arrest
UBC-related	0.4842	INHERITED FROM: late larval arrest
Ribonuclease PH domain 2-like	0.7124	INHERITED FROM: early larval arrest
Ribonuclease PH domain 1-like	0.7124	INHERITED FROM: early larval arrest
Canonical RBD	1	INHERITED FROM: late larval arrest

Trees by TreeVector

A presence/absence matrix is generated using protein domain architecture data for all genomes in SUPERFAMILY. The PAUP software is used to produce a single, large tree topology using heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as if individual trees had been produced. However, this data is extracted from the single large tree. This produces a higher quality topology than if the trees had been produced on their own, and allows the trees to be displayed instantly.

Supra-domains annotated to this WP term (SPWP level: Least Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Ribosomal protein L10-like	0	DIRECT
Ribosomal protein S10	0	DIRECT
ArfGap/RecO-like zinc finger	0	DIRECT
GroEL equatorial domain-like	0	DIRECT
PEP carboxykinase-like	0	DIRECT
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
Elafin-like	0	DIRECT
Zn-binding ribosomal proteins	0	DIRECT
Outer arm dynein light chain 1	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Heme-dependent catalase-like	0	DIRECT
Oxysterol-binding protein-like	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
Tubby C-terminal domain-like	0	DIRECT
Thyroglobulin type-1 domain	0	DIRECT
Cystatin/monellin	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
14-3-3 protein	0	DIRECT
ADP-ribosylation	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
beta-lactamase/transpeptidase-like	0	DIRECT
Chaperone J-domain	0	DIRECT
HSP20-like chaperones	0	DIRECT
L-aspartase-like	0	DIRECT
Hedgehog/intein (Hint) domain	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Proton glutamate symport protein	0	DIRECT
ARID-like	0	DIRECT
Tryptophan synthase beta subunit-like PLP-dependent enzymes	0	DIRECT
Hormone receptor domain	0	DIRECT
Annexin	0	DIRECT
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	DIRECT
LEM domain	0	DIRECT
Acid phosphatase/Vanadium-dependent haloperoxidase	0	DIRECT
PEP carboxykinase N-terminal domain	0	DIRECT
R3H domain	0	DIRECT
LysM domain	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
CBD9-like	0	DIRECT
Diaminopimelate epimerase-like	0	DIRECT
Nucleoporin domain	0	DIRECT
Subtilisin-like	0	DIRECT
DNA repair protein MutS, domain III	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
Heme-dependent peroxidases	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
Fibrinogen C-terminal domain-like	0	DIRECT
alpha/beta knot	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
JAB1/MPN domain	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Tricorn protease domain 2	0	DIRECT
Integrin alpha N-terminal domain	0	DIRECT
Pepsin inhibitor-3	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
Cadherin-like	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
GroEL apical domain-like	0	DIRECT
VPS9 domain	0	DIRECT
ThrRS/AlaRS common domain	0	DIRECT
Complement control module/SCR domain	0	DIRECT
2Fe-2S ferredoxin-like	0	DIRECT
MFPT repeat-like	0	DIRECT
Galactose oxidase, central domain	0	DIRECT
Ribosomal protein L1	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
Carbohydrate phosphatase	0	DIRECT
PHM/PNGase F	0	DIRECT
FF domain	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
PK beta-barrel domain-like	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
GAS2 domain-like	0	DIRECT
AN1-like Zinc finger	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
Protease propeptides/inhibitors	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
PABC (PABP) domain	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
LDH C-terminal domain-like	0	DIRECT
PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	DIRECT
Cytochrome c	0	DIRECT
Restriction endonuclease-like	0	DIRECT
eIF4e-like	0	DIRECT
Rap/Ran-GAP	0	DIRECT
FtsH protease domain-like	0	DIRECT
MIR domain	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
SAND domain-like	0	DIRECT
MgtE membrane domain-like	0	DIRECT
Pentein	0	DIRECT
Creatinase/prolidase N-terminal domain	0	DIRECT
TGS-like	0	DIRECT
Terpenoid synthases	0	DIRECT
HRDC-like	0	DIRECT
Small-conductance potassium channel	0	DIRECT
Formate/glycerate dehydrogenase catalytic domain-like	0	DIRECT
Chitinase insertion domain	0	DIRECT
Doublecortin (DC)	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
GYF domain	0	DIRECT
Phosphoenolpyruvate/pyruvate domain	0	DIRECT
SPOC domain-like	0	DIRECT
Ribokinase-like	0	DIRECT
Citrate synthase	0	DIRECT
Arginase/deacetylase	0	DIRECT
WGR domain-like	0	DIRECT
FAD-linked oxidases, C-terminal domain	0	DIRECT
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Phoshotransferase/anion transport protein	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
FAD-binding/transporter-associated domain-like	0	DIRECT
Terpenoid cyclases/Protein prenyltransferases	0	DIRECT
PEBP-like	0	DIRECT
Radical SAM enzymes	0	DIRECT
Sec7 domain	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
PapD-like	0.0003663	DIRECT
Mitochondrial carrier	0.0006411	DIRECT
POZ domain	0.003999	INHERITED FROM: L1 arrest || early larval arrest
Ribosomal protein S5 domain 2-like	0.1985	INHERITED FROM: early larval arrest
Protein kinase-like (PK-like)	0.2832	INHERITED FROM: mid larval arrest
Quinoprotein alcohol dehydrogenase-like	0.3625	INHERITED FROM: L2 arrest || mid larval arrest
Translation proteins SH3-like domain	0.4033	INHERITED FROM: early larval arrest
WD40 repeat-like	0.5089	INHERITED FROM: late larval arrest || early larval arrest
UBC-like	0.5921	INHERITED FROM: late larval arrest
Ribonuclease PH domain 2-like	0.7226	INHERITED FROM: early larval arrest

Supra-domains annotated to this WP term (SPWP level: Least Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
81631,55003 81631 - PAP/OAS1 substrate-binding domain 55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	DIRECT
56176,55103 56176 - FAD-binding/transporter-associated domain-like 55103 - FAD-linked oxidases, C-terminal domain	0	DIRECT
47473,51695 47473 - EF-hand 51695 - PLC-like phosphodiesterases	0	DIRECT
48425,50729 48425 - Sec7 domain 50729 - PH domain-like	0	DIRECT
51971,54373 51971 - Nucleotide-binding domain 54373 - FAD-linked reductases, C-terminal domain	0	DIRECT
50677,52374 50677 - ValRS/IleRS/LeuRS editing domain 52374 - Nucleotidylyl transferase	0	DIRECT
52518,52518 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52518 - Thiamin diphosphate-binding fold (THDP-binding)	0	DIRECT
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like	0	DIRECT
57938,49493 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain	0	DIRECT
81324,53850 81324 - Voltage-gated potassium channels 53850 - Periplasmic binding protein-like II	0	DIRECT
47741,56176 47741 - CO dehydrogenase ISP C-domain like 56176 - FAD-binding/transporter-associated domain-like	0	DIRECT
54897,53187 54897 - Protease propeptides/inhibitors 53187 - Zn-dependent exopeptidases	0	DIRECT
54695,81382 54695 - POZ domain 81382 - Skp1 dimerisation domain-like	0	DIRECT
81383,52047 81383 - F-box domain 52047 - RNI-like	0	DIRECT
54495,46934 54495 - UBC-like 46934 - UBA-like	0	DIRECT
54665,56003 54665 - CO dehydrogenase molybdoprotein N-domain-like 56003 - Molybdenum cofactor-binding domain	0	DIRECT
57362,57362 57362 - BPTI-like 57362 - BPTI-like	0	DIRECT
55486,50923 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain	0	DIRECT
54211,55060 54211 - Ribosomal protein S5 domain 2-like 55060 - GHMP Kinase, C-terminal domain	0	DIRECT
54897,52743 54897 - Protease propeptides/inhibitors 52743 - Subtilisin-like	0	DIRECT
49742,49742 49742 - PHM/PNGase F 49742 - PHM/PNGase F	0	DIRECT
51338,51556 51338 - Composite domain of metallo-dependent hydrolases 51556 - Metallo-dependent hydrolases	0	DIRECT
81383,50978 81383 - F-box domain 50978 - WD40 repeat-like	0	DIRECT
50978,50998 50978 - WD40 repeat-like 50998 - Quinoprotein alcohol dehydrogenase-like	0	DIRECT
56601,48403 56601 - beta-lactamase/transpeptidase-like 48403 - Ankyrin repeat	0	DIRECT
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
57414,57414 57414 - Hairpin loop containing domain-like 57414 - Hairpin loop containing domain-like	0	DIRECT
81324,81296 81324 - Voltage-gated potassium channels 81296 - E set domains	0	DIRECT
144232,82199 144232 - HIT/MYND zinc finger-like 82199 - SET domain	0	DIRECT
68923,53795 68923 - PEP carboxykinase N-terminal domain 53795 - PEP carboxykinase-like	0	DIRECT
49493,49493 49493 - HSP40/DnaJ peptide-binding domain 49493 - HSP40/DnaJ peptide-binding domain	0	DIRECT
81324,81327 81324 - Voltage-gated potassium channels 81327 - Small-conductance potassium channel	0	DIRECT
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0	DIRECT
47587,56399 47587 - Domain of poly(ADP-ribose) polymerase 56399 - ADP-ribosylation	0	DIRECT
52283,51735 52283 - Formate/glycerate dehydrogenase catalytic domain-like 51735 - NAD(P)-binding Rossmann-fold domains	0	DIRECT
74650,51445 74650 - Galactose mutarotase-like 51445 - (Trans)glycosidases	0	DIRECT
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
50156,50044 50156 - PDZ domain-like 50044 - SH3-domain	0	DIRECT
47203,47203 47203 - Acyl-CoA dehydrogenase C-terminal domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like	0	DIRECT
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat	0	DIRECT
53187,55031 53187 - Zn-dependent exopeptidases 55031 - Bacterial exopeptidase dimerisation domain	0	DIRECT
57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0	DIRECT
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
55920,46785 55920 - Creatinase/aminopeptidase 46785 - "Winged helix" DNA-binding domain	0	DIRECT
55326,56042 55326 - PurM N-terminal domain-like 56042 - PurM C-terminal domain-like	0	DIRECT
48334,52540 48334 - DNA repair protein MutS, domain III 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
54534,54534 54534 - FKBP-like 54534 - FKBP-like	0	DIRECT
141739,141739 141739 - MFPT repeat-like 141739 - MFPT repeat-like	0	DIRECT
47473,103506 47473 - EF-hand 103506 - Mitochondrial carrier	0	DIRECT
49313,49313 49313 - Cadherin-like 49313 - Cadherin-like	0	DIRECT
57196,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
81698,81698 81698 - FF domain 81698 - FF domain	0	DIRECT
51445,54556 51445 - (Trans)glycosidases 54556 - Chitinase insertion domain	0	DIRECT
54001,49758 54001 - Cysteine proteinases 49758 - Calpain large subunit, middle domain (domain III)	0	DIRECT
50044,52540 50044 - SH3-domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
161093,161093 161093 - MgtE membrane domain-like 161093 - MgtE membrane domain-like	0	DIRECT
55973,55973 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase	0	DIRECT
55394,55394 55394 - Bactericidal permeability-increasing protein, BPI 55394 - Bactericidal permeability-increasing protein, BPI	0	DIRECT
51735,56327 51735 - NAD(P)-binding Rossmann-fold domains 56327 - LDH C-terminal domain-like	0	DIRECT
57903,51197 57903 - FYVE/PHD zinc finger 51197 - Clavaminate synthase-like	0	DIRECT
56112,48371 56112 - Protein kinase-like (PK-like) 48371 - ARM repeat	0	DIRECT
52743,49785 52743 - Subtilisin-like 49785 - Galactose-binding domain-like	0	DIRECT
47769,47769 47769 - SAM/Pointed domain 47769 - SAM/Pointed domain	0	DIRECT
57903,82199 57903 - FYVE/PHD zinc finger 82199 - SET domain	0	DIRECT
46785,46785 46785 - "Winged helix" DNA-binding domain 46785 - "Winged helix" DNA-binding domain	0	DIRECT
52540,140990 52540 - P-loop containing nucleoside triphosphate hydrolases 140990 - FtsH protease domain-like	0	DIRECT
57850,117839 57850 - RING/U-box 117839 - WWE domain	0	DIRECT
48403,52151 48403 - Ankyrin repeat 52151 - FabD/lysophospholipase-like	0	DIRECT
52540,46785 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain	0	DIRECT
48179,48179 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like	0	DIRECT
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
141673,50800 141673 - MOSC N-terminal domain-like 50800 - PK beta-barrel domain-like	0	DIRECT
161111,160240 161111 - Cation efflux protein transmembrane domain-like 160240 - Cation efflux protein cytoplasmic domain-like	0	DIRECT
52540,81271 52540 - P-loop containing nucleoside triphosphate hydrolases 81271 - TGS-like	0	DIRECT
64356,49447 64356 - SNARE-like 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
57863,48403 57863 - ArfGap/RecO-like zinc finger 48403 - Ankyrin repeat	0	DIRECT
55486,57552 55486 - Metalloproteases ("zincins"), catalytic domain 57552 - Blood coagulation inhibitor (disintegrin)	0	DIRECT
57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain	0	DIRECT
54292,47741 54292 - 2Fe-2S ferredoxin-like 47741 - CO dehydrogenase ISP C-domain like	0	DIRECT
54211,55666 54211 - Ribosomal protein S5 domain 2-like 55666 - Ribonuclease PH domain 2-like	0.7226	INHERITED FROM: early larval arrest
54928,54928 54928 - RNA-binding domain, RBD 54928 - RNA-binding domain, RBD	1	INHERITED FROM: late larval arrest