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Worm Phenotype (WP): early embryonic lethal

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   Variant [WBPhenotype:0000886] <2>
+ + + + + 5:   physiology variant [WBPhenotype:0000519] <15>(509|582) (509|247|68)
+ + + + 4:   development variant [WBPhenotype:0000518] <6>(507|580) (507|247|68)
+ + + 3:   organism development variant [WBPhenotype:0000531] <10>(504|578) (504|247|68)
+ + 2:   embryonic development variant [WBPhenotype:0000749] <21>(445|532) (445|232|63)
+ + 2:   lethal [WBPhenotype:0000062] <5>(497|575) (497|246|68)
+ 1:   embryonic lethal [WBPhenotype:0000050] <7>(443|532) (443|231|63)
0:   early embryonic lethal [WBPhenotype:0001100] <31>(53|58) (55|23|4)
- 1:   meiosis defective early emb [WBPhenotype:0001041] <10>(34|31) (34|14|4)
- 1:   meiosis variant [WBPhenotype:0000775] <10>(34|31) (34|14|4)
- 1:   nuclear appearance number defective early emb [WBPhenotype:0001035] <9>(5|7) (5|3|0)
- 1:   nuclear morphology variation early emb [WBPhenotype:0001026] <9>(6|8) (6|4|0)
- 1:   nucleus defective early emb [WBPhenotype:0001138] <9>(5|7) (5|3|0)
- 1:   pronuclear morphology defective early emb [WBPhenotype:0001159] <9>(5|7) (5|3|0)
- 1:   pronuclear nuclear appearance defective early emb [WBPhenotype:0001034] <9>(5|7) (5|3|0)
- 1:   pronucleus centrosomes defective early emb [WBPhenotype:0001151] <9>(5|7) (5|3|0)
- 1:   cytoplasmic appearance defective early emb [WBPhenotype:0000769] <4>(4|4) (4|2|0)
- 1:   cytoplasmic morphology defective early emb [WBPhenotype:0001081] <4>(4|4) (4|2|0)
- 1:   aster defective early emb [WBPhenotype:0001110] <3>(0|0) (0|0|0)
- 1:   cytokinesis defective early emb [WBPhenotype:0001078] <3>(5|8) (5|0|0)
- 1:   cell position defective early emb [WBPhenotype:0001118] <2>(1|0) (1|0|0)
- 1:   egg integrity defective early emb [WBPhenotype:0001178] <2>(2|1) (2|0|0)
- 1:   embryonic morphology defective early emb [WBPhenotype:0001135] <2>(0|0) (0|0|0)
- 1:   other abnormality early emb [WBPhenotype:0001007] <2>(11|6) (11|2|1)
- 1:   polar body defective early emb [WBPhenotype:0001147] <2>(2|2) (2|2|0)
- 1:   pseudocleavage defective early emb [WBPhenotype:0001167] <2>(0|0) (0|0|0)
- 1:   spindle defective early emb [WBPhenotype:0000759] <2>(7|11) (7|5|0)
- 1:   cell cell contacts abnormal early emb [WBPhenotype:0001117] <1>(2|1) (2|0|0)
- 1:   cell cycle defective early emb [WBPhenotype:0001114] <1>(2|2) (2|0|0)
- 1:   embryonic developmental delay early emb [WBPhenotype:0001185] <1>(0|0) (0|0|0)
- 1:   Aba ABp division axis defective early emb [WBPhenotype:0001134](2|1) (2|1|0)
- 1:   asymmetric cell division defective early emb [WBPhenotype:0000748](0|0) (0|0|0)
- 1:   centrosome attachment defective early emb [WBPhenotype:0000771](0|0) (0|0|0)
- 1:   chromosome segregation variant karyomeres early emb [WBPhenotype:0001077](1|1) (1|1|0)
- 1:   cortical dynamics defective early emb [WBPhenotype:0001044](0|0) (0|0|0)
- 1:   egg size defective early emb [WBPhenotype:0000044](0|0) (1|0|0)
- 1:   integrity of membranous organelles defective early emb [WBPhenotype:0000767](0|0) (0|0|0)
- 1:   interphase entry defective early emb [WBPhenotype:0001043](0|0) (0|0|0)
- 1:   one cell arrest early emb [WBPhenotype:0000040](2|3) (2|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Zn-finger domain of Sec23/240Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
LEM domain0Direct
The spindle assembly checkpoint protein mad20Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Helical domain of Sec23/240Direct
Smc hinge domain0Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Histone-fold0Direct
ARM repeat0.00000000000002259Direct
Skp1 dimerisation domain-like0.00000000000009443Direct
Nucleic acid-binding proteins0.000000000000734Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.000000000169Direct
GroEL equatorial domain-like0.000000002858Direct
GroEL-intermediate domain like0.000000002858Direct
"Winged helix" DNA-binding domain0.000000004127Direct
GroEL apical domain-like0.00000002562Direct
Class II aaRS and biotin synthetases0.0000001491Direct
Zn-binding ribosomal proteins0.0000002899Direct
WD40 repeat-like0.000001612Direct
Activating enzymes of the ubiquitin-like proteins0.000002045Direct
Translation proteins SH3-like domain0.000009054Direct
S15/NS1 RNA-binding domain0.00002795Direct
Tubulin C-terminal domain-like0.0000289Direct
Sm-like ribonucleoproteins0.00005198Direct
Prefoldin0.00006245Direct
Tubulin nucleotide-binding domain-like0.0001516Direct
TPR-like0.0002477Direct
beta-sandwich domain of Sec23/240.0002667Direct
ADC-like0.0002667Direct
Cdc48 domain 2-like0.0002667Direct
DNA ligase/mRNA capping enzyme, catalytic domain0.0002667Direct
Cyclin-like0.0004725Direct
Translation proteins0.001027Inherited
Ribosomal proteins S24e, L23 and L15e0.001149Inherited
F1F0 ATP synthase subunit C0.001149Inherited
Nucleotidylyl transferase0.001411Inherited
L30e-like0.002097Inherited
Translational machinery components0.003006Inherited
Calponin-homology domain, CH-domain0.003286Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.006031Inherited
POZ domain0.006236Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.01717Inherited
Ribosomal protein S5 domain 2-like0.01744Inherited
SNARE-like0.01853Inherited
GTPase activation domain, GAP0.0428Inherited
Invertebrate chitin-binding proteins0.04791Inherited
DNA/RNA polymerases0.06216Inherited
BAR/IMD domain-like0.08049Inherited
UBC-like0.3751Inherited
Multidrug efflux transporter AcrB transmembrane domain0.5208Inherited
Protein kinase-like (PK-like)0.7129Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Proteasome subunits0Direct
Group II chaperonin (CCT, TRIC), ATPase domain0Direct
Nucleosome core histones0Direct
LEM domain0Direct
beta-sandwich domain of Sec23/240Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0Direct
Smc hinge domain0Direct
Zn-finger domain of Sec23/240Direct
a tRNA synthase domain0Direct
Helical domain of Sec23/240Direct
Ubiquitin activating enzymes (UBA)0Direct
Trunk domain of Sec23/240Direct
Anticodon-binding domain of Class II aaRS0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
Skp1 dimerisation domain-like0.0000000000002992Direct
Extended AAA-ATPase domain0.00000000001592Direct
Group II chaperonin (CCT, TRIC), apical domain0.00000001058Direct
Armadillo repeat0.00000006421Direct
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.0000001538Direct
BTB/POZ domain0.0000003185Direct
RecA protein-like (ATPase-domain)0.00000621Direct
Cyclin0.00001734Direct
WD40-repeat0.00002118Direct
Motor proteins0.00002613Direct
Prefoldin0.00003766Direct
Pumilio repeat0.00005981Direct
Actin/HSP700.00007299Direct
Tubulin, C-terminal domain0.00009284Direct
G proteins0.00009621Direct
Tubulin, GTPase domain0.000407Direct
Cdc48 N-terminal domain-like0.0004099Direct
RNA editing terminal uridyl transferase 2, RET2, domain 20.0004099Direct
Cdc48 domain 2-like0.0004099Direct
Anticodon-binding domain0.0004099Direct
Sm motif of small nuclear ribonucleoproteins, SNRNP0.0005778Direct
Single strand DNA-binding domain, SSB0.0007508Direct
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.001074Inherited
Nitrogenase iron protein-like0.001446Inherited
DEP domain0.001753Inherited
L30e/L7ae ribosomal proteins0.001753Inherited
F1F0 ATP synthase subunit C0.001753Inherited
Translational machinery components0.001853Inherited
Cold shock DNA-binding domain-like0.006462Inherited
Calponin-homology domain, CH-domain0.008598Inherited
Clathrin adaptor core protein0.00927Inherited
DNA polymerase I0.00927Inherited
Tetratricopeptide repeat (TPR)0.02358Inherited
Elongation factors0.02431Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.02585Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.03814Inherited
BCR-homology GTPase activation domain (BH-domain)0.05705Inherited
PDZ domain0.2387Inherited
UBC-related0.5048Inherited
Multidrug efflux transporter AcrB transmembrane domain0.562Inherited
Protein kinases, catalytic subunit0.863Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Helical domain of Sec23/240Direct
Zn-finger domain of Sec23/240Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Histone-fold0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Smc hinge domain0Direct
The spindle assembly checkpoint protein mad20Direct
LEM domain0Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
ARM repeat0.00000000000001779Direct
Skp1 dimerisation domain-like0.00000000000007448Direct
Nucleic acid-binding proteins0.00000000000058Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.0000000001343Direct
GroEL equatorial domain-like0.000000002281Direct
GroEL-intermediate domain like0.000000002281Direct
"Winged helix" DNA-binding domain0.000000003297Direct
GroEL apical domain-like0.00000002054Direct
Class II aaRS and biotin synthetases0.00000012Direct
Zn-binding ribosomal proteins0.000000234Direct
WD40 repeat-like0.00000131Direct
Activating enzymes of the ubiquitin-like proteins0.000001663Direct
Translation proteins SH3-like domain0.000007383Direct
S15/NS1 RNA-binding domain0.00002288Direct
Tubulin C-terminal domain-like0.00002366Direct
Sm-like ribonucleoproteins0.00004263Direct
Prefoldin0.00005118Direct
Tubulin nucleotide-binding domain-like0.0001248Direct
TPR-like0.0002044Direct
Cdc48 domain 2-like0.0002204Direct
DNA ligase/mRNA capping enzyme, catalytic domain0.0002204Direct
beta-sandwich domain of Sec23/240.0002204Direct
ADC-like0.0002204Direct
Cyclin-like0.0003918Direct
Translation proteins0.0008571Direct
Class II aaRS ABD-related0.0008808Direct
CAD & PB1 domains0.0009598Direct
F1F0 ATP synthase subunit C0.0009598Direct
Ribosomal proteins S24e, L23 and L15e0.0009598Direct
Nucleotidylyl transferase0.001181Inherited
L30e-like0.001763Inherited
Translational machinery components0.00254Inherited
Calponin-homology domain, CH-domain0.00278Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.005143Inherited
POZ domain0.005322Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0149Inherited
Ribosomal protein S5 domain 2-like0.01513Inherited
SNARE-like0.01609Inherited
GTPase activation domain, GAP0.03785Inherited
Invertebrate chitin-binding proteins0.04249Inherited
DNA/RNA polymerases0.05544Inherited
BAR/IMD domain-like0.07231Inherited
UBC-like0.3546Inherited
Multidrug efflux transporter AcrB transmembrane domain0.4991Inherited
Protein kinase-like (PK-like)0.6921Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.0000000000001373Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.000000002281Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.000000002281Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.00001238Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.00003605Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.0001248Direct
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0.0002204Direct
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0.0002204Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.0003238Direct
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0.0009598Direct
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.002265Inherited
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0.00254Inherited
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0.005214Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.008331Inherited
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0149Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.03202Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04827Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.000000002281Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0149Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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