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Worm Phenotype (WP): early embryonic lethal

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   Variant [WBPhenotype:0000886] <5>
+ + + + 4:   development variant [WBPhenotype:0000518] <7>(511|586) (511|253|70)
+ + + 3:   organism development variant [WBPhenotype:0000531] <10>(505|584) (505|253|70)
+ + 2:   lethal [WBPhenotype:0000062] <5>(504|583) (504|253|70)
+ + 2:   embryonic development variant [WBPhenotype:0000749] <23>(464|553) (464|243|67)
+ 1:   embryonic lethal [WBPhenotype:0000050] <7>(463|553) (463|243|67)
0:   early embryonic lethal [WBPhenotype:0001100] <30>(61|62) (61|26|4)
- 1:   meiosis defective early emb [WBPhenotype:0001041] <11>(37|33) (37|16|4)
- 1:   meiosis variant [WBPhenotype:0000775] <11>(37|33) (37|16|4)
- 1:   nuclear appearance number defective early emb [WBPhenotype:0001035] <9>(5|7) (5|3|0)
- 1:   nuclear morphology variation early emb [WBPhenotype:0001026] <9>(6|8) (6|4|0)
- 1:   nucleus defective early emb [WBPhenotype:0001138] <9>(5|7) (5|3|0)
- 1:   pronuclear morphology defective early emb [WBPhenotype:0001159] <9>(5|7) (5|3|0)
- 1:   pronuclear nuclear appearance defective early emb [WBPhenotype:0001034] <9>(5|7) (5|3|0)
- 1:   pronucleus centrosomes defective early emb [WBPhenotype:0001151] <9>(5|7) (5|3|0)
- 1:   cytoplasmic appearance defective early emb [WBPhenotype:0000769] <4>(4|4) (4|2|0)
- 1:   cytoplasmic morphology defective early emb [WBPhenotype:0001081] <4>(4|4) (4|2|0)
- 1:   aster defective early emb [WBPhenotype:0001110] <3>(0|0) (0|0|0)
- 1:   cytokinesis defective early emb [WBPhenotype:0001078] <3>(6|8) (6|0|0)
- 1:   cell position defective early emb [WBPhenotype:0001118] <2>(1|0) (1|0|0)
- 1:   egg integrity defective early emb [WBPhenotype:0001178] <2>(2|1) (2|0|0)
- 1:   embryonic morphology defective early emb [WBPhenotype:0001135] <2>(0|0) (0|0|0)
- 1:   other abnormality early emb [WBPhenotype:0001007] <2>(11|6) (11|2|1)
- 1:   polar body defective early emb [WBPhenotype:0001147] <2>(2|2) (2|2|0)
- 1:   pseudocleavage defective early emb [WBPhenotype:0001167] <2>(0|0) (0|0|0)
- 1:   spindle defective early emb [WBPhenotype:0000759] <2>(7|11) (7|5|0)
- 1:   cell cell contacts defective early emb [WBPhenotype:0001117] <1>(2|1) (2|0|0)
- 1:   cell cycle defective early emb [WBPhenotype:0001114] <1>(2|2) (2|0|0)
- 1:   Aba ABp division axis defective early emb [WBPhenotype:0001134](2|1) (2|1|0)
- 1:   asymmetric cell division defective early emb [WBPhenotype:0000748](0|0) (0|0|0)
- 1:   centrosome attachment defective early emb [WBPhenotype:0000771](0|0) (0|0|0)
- 1:   chromosome segregation variant karyomeres early emb [WBPhenotype:0001077](1|1) (1|1|0)
- 1:   cortical dynamics defective early emb [WBPhenotype:0001044](0|0) (0|0|0)
- 1:   egg size defective early emb [WBPhenotype:0000044](0|0) (1|0|0)
- 1:   integrity of membranous organelles defective early emb [WBPhenotype:0000767](0|0) (0|0|0)
- 1:   interphase entry defective early emb [WBPhenotype:0001043](0|0) (0|0|0)
- 1:   one cell arrest early emb [WBPhenotype:0000040](2|3) (2|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Helical domain of Sec23/240Direct
Zn-finger domain of Sec23/240Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Ribosomal protein L10Direct
The spindle assembly checkpoint protein mad20Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
Histone-fold0Direct
LEM domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Skp1 dimerisation domain-like0.0000000000002551Direct
ARM repeat0.000000000000331Direct
Nucleic acid-binding proteins0.000000000002394Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.000000000435Direct
"Winged helix" DNA-binding domain0.000000001037Direct
Class II aaRS and biotin synthetases0.000000001209Direct
GroEL-intermediate domain like0.000000004955Direct
GroEL equatorial domain-like0.000000004955Direct
GroEL apical domain-like0.00000004406Direct
WD40 repeat-like0.0000002773Direct
Zn-binding ribosomal proteins0.0000004463Direct
Activating enzymes of the ubiquitin-like proteins0.00000313Direct
Smc hinge domain0.000004165Direct
Translation proteins SH3-like domain0.00001433Direct
S15/NS1 RNA-binding domain0.0000382Direct
Tubulin C-terminal domain-like0.00004734Direct
Sm-like ribonucleoproteins0.00008454Direct
Class II aaRS ABD-related0.00008905Direct
Prefoldin0.00008905Direct
Cyclin-like0.0001721Direct
Tubulin nucleotide-binding domain-like0.0002328Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.0002344Direct
L30e-like0.0002344Direct
TPR-like0.0002384Direct
beta-sandwich domain of Sec23/240.0003431Direct
ADC-like0.0003431Direct
Cdc48 domain 2-like0.0003431Direct
DNA ligase/mRNA capping enzyme, catalytic domain0.0003431Direct
DNA repair protein MutS, domain III0.0003431Direct
Cullin homology domain0.0006009Direct
Nucleotidylyl transferase0.0006277Direct
Actin-like ATPase domain0.000642Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0009983Direct
F1F0 ATP synthase subunit C0.001456Inherited
Ribosomal proteins S24e, L23 and L15e0.001456Inherited
Translation proteins0.001578Inherited
Ribosomal protein S5 domain 2-like0.00311Inherited
Translational machinery components0.003754Inherited
FKBP-like0.00462Inherited
Calponin-homology domain, CH-domain0.004895Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.02108Inherited
Quinoprotein alcohol dehydrogenase-like0.02232Inherited
SNARE-like0.02347Inherited
POZ domain0.02864Inherited
GTPase activation domain, GAP0.05743Inherited
Invertebrate chitin-binding proteins0.0577Inherited
DNA/RNA polymerases0.09306Inherited
BAR/IMD domain-like0.1005Inherited
UBC-like0.1165Inherited
Protein kinase-like (PK-like)0.2709Inherited
Multidrug efflux transporter AcrB transmembrane domain0.577Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Trunk domain of Sec23/240Direct
beta-sandwich domain of Sec23/240Direct
Ribosomal protein L10Direct
Helical domain of Sec23/240Direct
a tRNA synthase domain0Direct
Group II chaperonin (CCT, TRIC), ATPase domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
Proteasome subunits0Direct
Nucleosome core histones0Direct
DNA gyrase/MutL, second domain0Direct
Anticodon-binding domain of Class II aaRS0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
LEM domain0Direct
Ubiquitin activating enzymes (UBA)0Direct
Zn-finger domain of Sec23/240Direct
Skp1 dimerisation domain-like0.0000000000009065Direct
Extended AAA-ATPase domain0.0000000001386Direct
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.0000000011Direct
Group II chaperonin (CCT, TRIC), apical domain0.00000001954Direct
Armadillo repeat0.0000001242Direct
BTB/POZ domain0.0000007814Direct
WD40-repeat0.000003584Direct
Cyclin0.000003868Direct
RecA protein-like (ATPase-domain)0.000009393Direct
Actin/HSP700.00002145Direct
Prefoldin0.00005641Direct
Motor proteins0.00005813Direct
Smc hinge domain0.00007211Direct
L30e/L7ae ribosomal proteins0.00007211Direct
Tubulin, C-terminal domain0.0001591Direct
Pumilio repeat0.0002245Direct
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.0002775Direct
G proteins0.0003785Direct
Cdc48 N-terminal domain-like0.0005431Direct
RNA editing terminal uridyl transferase 2, RET2, domain 20.0005431Direct
Cdc48 domain 2-like0.0005431Direct
DNA repair protein MutS, domain III0.0005431Direct
Anticodon-binding domain0.0005431Direct
DNA gyrase/MutL, N-terminal domain0.0005431Direct
Tubulin, GTPase domain0.0006518Direct
Sm motif of small nuclear ribonucleoproteins, SNRNP0.0008795Direct
Nitrogenase iron protein-like0.002085Inherited
F1F0 ATP synthase subunit C0.002296Inherited
DEP domain0.002296Inherited
Translational machinery components0.002547Inherited
FKBP immunophilin/proline isomerase0.008277Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.008628Inherited
Cold shock DNA-binding domain-like0.009172Inherited
DNA polymerase I0.01191Inherited
Clathrin adaptor core protein0.01191Inherited
Calponin-homology domain, CH-domain0.01325Inherited
Tetratricopeptide repeat (TPR)0.01433Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.03258Inherited
Elongation factors0.03289Inherited
BCR-homology GTPase activation domain (BH-domain)0.07657Inherited
PDZ domain0.1314Inherited
Protein kinases, catalytic subunit0.4347Inherited
UBC-related0.5654Inherited
Multidrug efflux transporter AcrB transmembrane domain0.6265Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Ribosomal protein L10Direct
Zn-finger domain of Sec23/240Direct
LEM domain0Direct
Helical domain of Sec23/240Direct
Histone-fold0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
The spindle assembly checkpoint protein mad20Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
Skp1 dimerisation domain-like0.0000000000001987Direct
ARM repeat0.000000000000258Direct
Nucleic acid-binding proteins0.00000000000187Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.0000000003423Direct
"Winged helix" DNA-binding domain0.0000000008169Direct
Class II aaRS and biotin synthetases0.0000000009532Direct
GroEL equatorial domain-like0.000000003918Direct
GroEL-intermediate domain like0.000000003918Direct
GroEL apical domain-like0.000000035Direct
WD40 repeat-like0.0000002214Direct
Zn-binding ribosomal proteins0.0000003569Direct
Activating enzymes of the ubiquitin-like proteins0.000002523Direct
Smc hinge domain0.000003358Direct
Translation proteins SH3-like domain0.0000116Direct
S15/NS1 RNA-binding domain0.00003103Direct
Tubulin C-terminal domain-like0.00003849Direct
Sm-like ribonucleoproteins0.00006883Direct
Class II aaRS ABD-related0.00007256Direct
Prefoldin0.00007256Direct
Cyclin-like0.0001404Direct
Tubulin nucleotide-binding domain-like0.0001904Direct
L30e-like0.0001917Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.0001917Direct
TPR-like0.000195Direct
DNA repair protein MutS, domain III0.0002812Direct
DNA ligase/mRNA capping enzyme, catalytic domain0.0002812Direct
Cdc48 domain 2-like0.0002812Direct
ADC-like0.0002812Direct
beta-sandwich domain of Sec23/240.0002812Direct
Cullin homology domain0.0004943Direct
Nucleotidylyl transferase0.0005168Direct
Actin-like ATPase domain0.0005289Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0008257Direct
Ribosomal proteins S24e, L23 and L15e0.001209Inherited
F1F0 ATP synthase subunit C0.001209Inherited
Translation proteins0.001312Inherited
Ribosomal protein S5 domain 2-like0.002611Inherited
Translational machinery components0.003159Inherited
FKBP-like0.003897Inherited
Calponin-homology domain, CH-domain0.004134Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.01826Inherited
Quinoprotein alcohol dehydrogenase-like0.01936Inherited
SNARE-like0.02038Inherited
POZ domain0.025Inherited
GTPase activation domain, GAP0.05091Inherited
Invertebrate chitin-binding proteins0.05117Inherited
DNA/RNA polymerases0.08359Inherited
BAR/IMD domain-like0.09051Inherited
UBC-like0.1054Inherited
Protein kinase-like (PK-like)0.2521Inherited
Multidrug efflux transporter AcrB transmembrane domain0.5546Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.0000000000003471Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.000000003918Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.000000003918Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.00002026Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.000056Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.0001122Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.0001904Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0002812Direct
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0.0002812Direct
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0.0004943Direct
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0.001209Inherited
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0.001209Inherited
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0.003159Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.003277Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.01102Inherited
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.01826Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.03648Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.03919Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.000000003918Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.01826Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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