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Worm Phenotype (WP): protein interaction variant

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Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   Variant [WBPhenotype:0000886] <5>
+ + + + 4:   physiology variant [WBPhenotype:0000519] <6>(490|567) (491|248|69)
+ + + 3:   organism physiology variant [WBPhenotype:0000576] <10>(359|429) (362|200|61)
+ + 2:   organism homeostasis metabolism variant [WBPhenotype:0000577] <17>(347|416) (351|198|60)
+ 1:   organism metabolism processing variant [WBPhenotype:0000027] <24>(170|181) (176|83|25)
0:   protein interaction variant [WBPhenotype:0001369] <3>(47|48) (48|21|9)
- 1:   protein RNA interaction variant [WBPhenotype:0001371] <2>(0|0) (0|0|0)
- 1:   protein protein interaction variant [WBPhenotype:0001370] <2>(47|48) (48|21|9)
- 1:   protein DNA interaction variant [WBPhenotype:0001372](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
JAB1/MPN domain0Direct
RING/U-box0Direct
Cu,Zn superoxide dismutase-like0Direct
14-3-3 protein0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Cysteine proteinases0.000000000000004447Direct
Acid proteases0.000000000001059Direct
UBC-like0.00000000001164Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000002471Direct
Chaperone J-domain0.0000000007873Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.000000002544Direct
Hect, E3 ligase catalytic domain0.000000002544Direct
B-box zinc-binding domain0.0000002424Direct
Cyclophilin-like0.0000008464Direct
FKBP-like0.0000009362Direct
Activating enzymes of the ubiquitin-like proteins0.00000188Direct
HSP20-like chaperones0.000007161Direct
Ubiquitin-like0.00003005Direct
GroEL-intermediate domain like0.00003525Direct
GroEL equatorial domain-like0.00003525Direct
Tubulin nucleotide-binding domain-like0.00004913Direct
Galactose-binding domain-like0.0000568Direct
EF-hand0.0000618Direct
Actin-like ATPase domain0.0001213Direct
Tubulin C-terminal domain-like0.0001489Direct
GroEL apical domain-like0.0002462Direct
Cdc48 domain 2-like0.0002552Direct
WWE domain0.0002552Direct
MIT domain0.0002552Direct
ADC-like0.0002552Direct
HSP40/DnaJ peptide-binding domain0.001101Inherited
UBA-like0.002678Inherited
Seven-hairpin glycosidases0.00452Inherited
Sec1/munc18-like (SM) proteins0.00452Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.006576Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.008508Inherited
Skp1 dimerisation domain-like0.0263Inherited
PYP-like sensor domain (PAS domain)0.04568Inherited
Cullin homology domain0.04568Inherited
"Winged helix" DNA-binding domain0.05207Inherited
Translation proteins0.0798Inherited
WD40 repeat-like0.08066Inherited
Cullin repeat-like0.08716Inherited
RNI-like0.7112Inherited
POZ domain1Inherited
F-box domain1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
14-3-3 protein0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
RING finger domain, C3HC40Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
Cu,Zn superoxide dismutase-like0Direct
PDI-like0Direct
Pepsin-like0.000000000000003768Direct
UBC-related0.0000000000005983Direct
Papain-like0.0000000004054Direct
Chaperone J-domain0.0000000005938Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000009775Direct
Ubiquitin carboxyl-terminal hydrolase, UCH0.000000001365Direct
HSP200.000000008504Direct
Hect, E3 ligase catalytic domain0.000000008504Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.00000007381Direct
Extended PAW domain0.0000001169Direct
Ubiquitin-related0.0000001686Direct
B-box zinc-binding domain0.0000001822Direct
Cyclophilin (peptidylprolyl isomerase)0.0000006387Direct
FKBP immunophilin/proline isomerase0.000002568Direct
Calmodulin-like0.00000608Direct
Actin/HSP700.00001657Direct
Tubulin, GTPase domain0.00003764Direct
Ubiquitin activating enzymes (UBA)0.0000454Direct
Group II chaperonin (CCT, TRIC), ATPase domain0.00009251Direct
Tubulin, C-terminal domain0.0001152Direct
MIT domain0.0003759Direct
Cdc48 domain 2-like0.0003759Direct
WWE domain0.0003759Direct
Cdc48 N-terminal domain-like0.0003759Direct
Group II chaperonin (CCT, TRIC), apical domain0.0005874Direct
Sec1/munc18-like (SM) proteins0.003634Inherited
Class I alpha-1;2-mannosidase, catalytic domain0.003634Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.005322Inherited
Elongation factors0.005529Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP0.005749Inherited
Proteasome subunits0.01012Inherited
Cullin repeat0.01542Inherited
RecA protein-like (ATPase-domain)0.01542Inherited
SCF ubiquitin ligase complex WHB domain0.01542Inherited
Skp1 dimerisation domain-like0.03659Inherited
Clathrin adaptor core protein0.03896Inherited
Cullin homology domain0.03896Inherited
BTB/POZ domain0.2759Inherited
WD40-repeat0.4554Inherited
F-box domain0.6687Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
RING/U-box0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
JAB1/MPN domain0Direct
Cu,Zn superoxide dismutase-like0Direct
14-3-3 protein0Direct
Cysteine proteinases0.000000000000003462Direct
Acid proteases0.0000000000008292Direct
UBC-like0.000000000009142Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000001948Direct
Chaperone J-domain0.0000000006217Direct
Hect, E3 ligase catalytic domain0.000000002013Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.000000002013Direct
B-box zinc-binding domain0.0000001938Direct
Cyclophilin-like0.0000006799Direct
FKBP-like0.0000007523Direct
Activating enzymes of the ubiquitin-like proteins0.000001516Direct
HSP20-like chaperones0.000005791Direct
Ubiquitin-like0.00002438Direct
GroEL equatorial domain-like0.00002862Direct
GroEL-intermediate domain like0.00002862Direct
Tubulin nucleotide-binding domain-like0.00003994Direct
Galactose-binding domain-like0.0000462Direct
EF-hand0.00005026Direct
Actin-like ATPase domain0.000099Direct
Tubulin C-terminal domain-like0.0001216Direct
GroEL apical domain-like0.0002014Direct
MIT domain0.0002089Direct
Cdc48 domain 2-like0.0002089Direct
WWE domain0.0002089Direct
ADC-like0.0002089Direct
HSP40/DnaJ peptide-binding domain0.0009116Direct
UBA-like0.002247Inherited
Sec1/munc18-like (SM) proteins0.00382Inherited
Seven-hairpin glycosidases0.00382Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.005582Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.007254Inherited
Skp1 dimerisation domain-like0.02292Inherited
PYP-like sensor domain (PAS domain)0.0402Inherited
Cullin homology domain0.0402Inherited
"Winged helix" DNA-binding domain0.04599Inherited
Translation proteins SH3-like domain0.06229Inherited
Translation proteins0.07124Inherited
WD40 repeat-like0.07203Inherited
Cullin repeat-like0.078Inherited
RNI-like0.6907Inherited
POZ domain1Inherited
F-box domain1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.000000002013Direct
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.00000004116Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.00002862Direct
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0.00002862Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.00002862Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.00003994Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.000099Direct
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0.0003355Direct
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.0008279Direct
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.0009116Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.005582Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.005782Inherited
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.01404Inherited
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0.01604Inherited
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.01604Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.000000002013Direct
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.00000009008Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.00002862Direct
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.0002089Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.005582Inherited
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.01604Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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    (show help)