SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Worm Phenotype (WP): protein interaction variant

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   Variant [WBPhenotype:0000886] <5>
+ + + + 4:   physiology variant [WBPhenotype:0000519] <6>(495|573) (496|248|69)
+ + + 3:   organism physiology variant [WBPhenotype:0000576] <10>(360|428) (362|200|61)
+ + 2:   organism homeostasis metabolism variant [WBPhenotype:0000577] <17>(348|415) (351|198|60)
+ 1:   organism metabolism processing variant [WBPhenotype:0000027] <24>(169|180) (176|83|25)
0:   protein interaction variant [WBPhenotype:0001369] <3>(47|48) (48|21|9)
- 1:   protein RNA interaction variant [WBPhenotype:0001371] <2>(0|0) (0|0|0)
- 1:   protein protein interaction variant [WBPhenotype:0001370] <2>(47|48) (48|21|9)
- 1:   protein DNA interaction variant [WBPhenotype:0001372](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
RING/U-box0Direct
Cu,Zn superoxide dismutase-like0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
14-3-3 protein0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
JAB1/MPN domain0Direct
Cysteine proteinases0.000000000000004435Direct
Acid proteases0.000000000001081Direct
UBC-like0.00000000001152Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.00000000025Direct
Chaperone J-domain0.00000000078Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.000000002571Direct
Hect, E3 ligase catalytic domain0.000000002571Direct
B-box zinc-binding domain0.0000002408Direct
Cyclophilin-like0.0000008409Direct
FKBP-like0.0000009442Direct
Activating enzymes of the ubiquitin-like proteins0.000001895Direct
HSP20-like chaperones0.00000711Direct
Ubiquitin-like0.0000298Direct
GroEL equatorial domain-like0.00003508Direct
GroEL-intermediate domain like0.00003508Direct
Tubulin nucleotide-binding domain-like0.00004884Direct
Galactose-binding domain-like0.00005647Direct
EF-hand0.00007673Direct
Actin-like ATPase domain0.0001207Direct
Tubulin C-terminal domain-like0.0001481Direct
GroEL apical domain-like0.0002453Direct
Cdc48 domain 2-like0.0002563Direct
WWE domain0.0002563Direct
ADC-like0.0002563Direct
MIT domain0.0002563Direct
HSP40/DnaJ peptide-binding domain0.001105Inherited
UBA-like0.002671Inherited
Sec1/munc18-like (SM) proteins0.004516Inherited
Seven-hairpin glycosidases0.004516Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.006562Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.008492Inherited
Skp1 dimerisation domain-like0.02645Inherited
Cullin homology domain0.04559Inherited
PYP-like sensor domain (PAS domain)0.04559Inherited
Translation proteins0.07952Inherited
WD40 repeat-like0.08021Inherited
Cullin repeat-like0.08696Inherited
"Winged helix" DNA-binding domain0.08874Inherited
RNI-like0.7126Inherited
POZ domain1Inherited
F-box domain1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Cu,Zn superoxide dismutase-like0Direct
14-3-3 protein0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
RING finger domain, C3HC40Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
PDI-like0Direct
Pepsin-like0.000000000000004076Direct
UBC-related0.0000000000006034Direct
Papain-like0.0000000004083Direct
Chaperone J-domain0.0000000005986Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000009935Direct
Ubiquitin carboxyl-terminal hydrolase, UCH0.000000001375Direct
Hect, E3 ligase catalytic domain0.000000008628Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.00000007472Direct
HSP200.00000007472Direct
Extended PAW domain0.000000119Direct
Ubiquitin-related0.0000001695Direct
B-box zinc-binding domain0.0000001829Direct
Cyclophilin (peptidylprolyl isomerase)0.0000006407Direct
FKBP immunophilin/proline isomerase0.000002601Direct
Calmodulin-like0.000006228Direct
Actin/HSP700.00001665Direct
Tubulin, GTPase domain0.0000378Direct
Ubiquitin activating enzymes (UBA)0.00004575Direct
Group II chaperonin (CCT, TRIC), ATPase domain0.00009276Direct
Tubulin, C-terminal domain0.0001157Direct
Cdc48 N-terminal domain-like0.0003781Direct
Cdc48 domain 2-like0.0003781Direct
WWE domain0.0003781Direct
MIT domain0.0003781Direct
Group II chaperonin (CCT, TRIC), apical domain0.0005888Direct
Sec1/munc18-like (SM) proteins0.003638Inherited
Class I alpha-1;2-mannosidase, catalytic domain0.003638Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.00533Inherited
Elongation factors0.005539Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP0.005758Inherited
Proteasome subunits0.01015Inherited
Cullin repeat0.01543Inherited
RecA protein-like (ATPase-domain)0.01543Inherited
SCF ubiquitin ligase complex WHB domain0.01543Inherited
Skp1 dimerisation domain-like0.03685Inherited
Clathrin adaptor core protein0.03899Inherited
Cullin homology domain0.03899Inherited
BTB/POZ domain0.2773Inherited
WD40-repeat0.4562Inherited
F-box domain0.6706Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
14-3-3 protein0Direct
RING/U-box0Direct
JAB1/MPN domain0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Cu,Zn superoxide dismutase-like0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Cysteine proteinases0.000000000000003462Direct
Acid proteases0.0000000000008488Direct
UBC-like0.000000000009068Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000001975Direct
Chaperone J-domain0.0000000006173Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.00000000204Direct
Hect, E3 ligase catalytic domain0.00000000204Direct
B-box zinc-binding domain0.0000001929Direct
Cyclophilin-like0.0000006768Direct
FKBP-like0.0000007602Direct
Activating enzymes of the ubiquitin-like proteins0.00000153Direct
HSP20-like chaperones0.000005758Direct
Ubiquitin-like0.00002421Direct
GroEL-intermediate domain like0.00002852Direct
GroEL equatorial domain-like0.00002852Direct
Tubulin nucleotide-binding domain-like0.00003976Direct
Galactose-binding domain-like0.00004598Direct
EF-hand0.00006255Direct
Actin-like ATPase domain0.00009853Direct
Tubulin C-terminal domain-like0.000121Direct
GroEL apical domain-like0.0002009Direct
MIT domain0.0002101Direct
Cdc48 domain 2-like0.0002101Direct
WWE domain0.0002101Direct
ADC-like0.0002101Direct
HSP40/DnaJ peptide-binding domain0.0009163Direct
UBA-like0.002243Inherited
Sec1/munc18-like (SM) proteins0.003817Inherited
Seven-hairpin glycosidases0.003817Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.005573Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.007242Inherited
Skp1 dimerisation domain-like0.02307Inherited
PYP-like sensor domain (PAS domain)0.04014Inherited
Cullin homology domain0.04014Inherited
Translation proteins SH3-like domain0.06212Inherited
Translation proteins0.07103Inherited
WD40 repeat-like0.07167Inherited
Cullin repeat-like0.07785Inherited
"Winged helix" DNA-binding domain0.07949Inherited
RNI-like0.6922Inherited
POZ domain1Inherited
F-box domain1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.00000000204Direct
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.00000004172Direct
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.0000009617Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.00002852Direct
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0.00002852Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.00002852Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.00003976Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.00009853Direct
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0.0003385Direct
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.0009163Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.005573Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.005768Inherited
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.01412Inherited
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0.01601Inherited
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.01601Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.00000000204Direct
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.0000000912Direct
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.0000001694Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.00002852Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.005573Inherited
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.01601Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)