SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Worm Phenotype (WP): protein protein interaction variant

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   Variant [WBPhenotype:0000886] <2>
+ + + + + 5:   physiology variant [WBPhenotype:0000519] <14>(510|587) (510|248|69)
+ + + + 4:   organism physiology variant [WBPhenotype:0000576] <9>(369|431) (372|193|57)
+ + + 3:   organism homeostasis metabolism variant [WBPhenotype:0000577] <16>(361|421) (363|190|56)
+ + 2:   organism metabolism processing variant [WBPhenotype:0000027] <25>(178|190) (182|87|26)
+ 1:   protein interaction variant [WBPhenotype:0001369] <4>(47|49) (48|21|9)
0:   protein protein interaction variant [WBPhenotype:0001370] <2>(44|49) (45|19|8)
- 1:   protein aggregation variant [WBPhenotype:0001405] <1>(43|48) (44|19|8)
- 1:   protein complex organization variant [WBPhenotype:0002132] <1>(0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
JAB1/MPN domain0Direct
Cu,Zn superoxide dismutase-like0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
RING/U-box0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
UBC-like0Direct
Cysteine proteinases0Direct
14-3-3 protein0Direct
Chaperone J-domain4.491e-16Direct
Acid proteases0.0000000000005707Direct
HSP20-like chaperones0.00000000002154Direct
Tubulin nucleotide-binding domain-like0.00000000008365Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000002292Direct
Tubulin C-terminal domain-like0.0000000003215Direct
B-box zinc-binding domain0.000000001049Direct
Hect, E3 ligase catalytic domain0.000000002384Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.000000002384Direct
Cyclophilin-like0.000000007896Direct
Actin-like ATPase domain0.00000003736Direct
Ubiquitin-like0.0000001896Direct
FKBP-like0.0000008839Direct
Activating enzymes of the ubiquitin-like proteins0.000001787Direct
Galactose-binding domain-like0.000001942Direct
WD40 repeat-like0.00003001Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.00008244Direct
"Winged helix" DNA-binding domain0.0001147Direct
Sec1/munc18-like (SM) proteins0.0001332Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0001484Direct
MIT domain0.0002478Direct
WWE domain0.0002478Direct
ADC-like0.0002478Direct
Cdc48 domain 2-like0.0002478Direct
Seven-hairpin glycosidases0.0004093Direct
Cullin homology domain0.0004093Direct
UBA-like0.00063Direct
Translation proteins0.0008868Direct
PYP-like sensor domain (PAS domain)0.0009634Direct
HSP40/DnaJ peptide-binding domain0.001068Inherited
Cullin repeat-like0.001914Inherited
Skp1 dimerisation domain-like0.02514Inherited
RNI-like0.6722Inherited
EF-hand0.8232Inherited
F-box domain0.9944Inherited
POZ domain1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
Cu,Zn superoxide dismutase-like0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
UBC-related0Direct
RING finger domain, C3HC40Direct
PDI-like0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
14-3-3 protein0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Chaperone J-domain0.00000000000001343Direct
Pepsin-like0.00000000000002964Direct
Papain-like0.000000000001135Direct
Ubiquitin carboxyl-terminal hydrolase, UCH0.00000000003419Direct
Tubulin, GTPase domain0.0000000005321Direct
Actin/HSP700.0000000005708Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000009188Direct
Tubulin, C-terminal domain0.000000002011Direct
Ubiquitin-related0.000000005893Direct
B-box zinc-binding domain0.000000006443Direct
Hect, E3 ligase catalytic domain0.000000008037Direct
Cyclophilin (peptidylprolyl isomerase)0.00000004085Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.00000007007Direct
HSP200.00000007007Direct
Extended PAW domain0.00000008872Direct
FKBP immunophilin/proline isomerase0.000002439Direct
Proteasome subunits0.000008651Direct
Calmodulin-like0.0000182Direct
Ubiquitin activating enzymes (UBA)0.00004386Direct
Cullin repeat0.0002271Direct
Sec1/munc18-like (SM) proteins0.0002271Direct
SCF ubiquitin ligase complex WHB domain0.0002271Direct
RecA protein-like (ATPase-domain)0.0002271Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0002898Direct
Cdc48 N-terminal domain-like0.0003641Direct
WWE domain0.0003641Direct
MIT domain0.0003641Direct
Cdc48 domain 2-like0.0003641Direct
Sm motif of small nuclear ribonucleoproteins, SNRNP0.0004785Direct
Clathrin adaptor core protein0.0006915Direct
Cullin homology domain0.0006915Direct
Class I alpha-1;2-mannosidase, catalytic domain0.0006915Direct
Elongation factors0.000875Direct
WD40-repeat0.03174Inherited
Skp1 dimerisation domain-like0.03503Inherited
Thioltransferase0.1037Inherited
F-box domain0.6261Inherited
BTB/POZ domain0.9793Inherited
Group II chaperonin (CCT, TRIC), ATPase domain0.9894Inherited
Group II chaperonin (CCT, TRIC), apical domain0.9894Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
14-3-3 protein0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Cu,Zn superoxide dismutase-like0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
UBC-like0Direct
Cysteine proteinases0Direct
RING/U-box0Direct
JAB1/MPN domain0Direct
Chaperone J-domain3.516e-16Direct
Acid proteases0.0000000000004489Direct
HSP20-like chaperones0.00000000001701Direct
Tubulin nucleotide-binding domain-like0.00000000006613Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000001815Direct
Tubulin C-terminal domain-like0.0000000002547Direct
B-box zinc-binding domain0.0000000008327Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.000000001894Direct
Hect, E3 ligase catalytic domain0.000000001894Direct
Cyclophilin-like0.000000006291Direct
Actin-like ATPase domain0.00000002987Direct
Ubiquitin-like0.0000001521Direct
FKBP-like0.0000007133Direct
Activating enzymes of the ubiquitin-like proteins0.000001447Direct
Galactose-binding domain-like0.000001572Direct
WD40 repeat-like0.00002449Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.00006747Direct
"Winged helix" DNA-binding domain0.00009401Direct
Sec1/munc18-like (SM) proteins0.0001091Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0001217Direct
Cdc48 domain 2-like0.0002037Direct
MIT domain0.0002037Direct
WWE domain0.0002037Direct
ADC-like0.0002037Direct
Cullin homology domain0.0003377Direct
Seven-hairpin glycosidases0.0003377Direct
UBA-like0.0005218Direct
Translation proteins0.0007373Direct
PYP-like sensor domain (PAS domain)0.0008013Direct
HSP40/DnaJ peptide-binding domain0.0008883Direct
Translation proteins SH3-like domain0.0009598Direct
Cullin repeat-like0.001604Inherited
Skp1 dimerisation domain-like0.02198Inherited
RNI-like0.6508Inherited
EF-hand0.8053Inherited
F-box domain0.9841Inherited
POZ domain1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.00000000006613Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.000000001725Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.000000001894Direct
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.00000003847Direct
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0.00000226Direct
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.00001479Direct
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0.00009193Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.0001091Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0.0001091Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0001217Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.0001829Direct
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.0008883Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.01343Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.000000001894Direct
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.00000008491Direct
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.000005815Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.0001091Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0001217Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)