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Worm Phenotype (WP): protein protein interaction variant

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Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   Variant [WBPhenotype:0000886] <5>
+ + + + + 5:   physiology variant [WBPhenotype:0000519] <6>(495|573) (496|248|69)
+ + + + 4:   organism physiology variant [WBPhenotype:0000576] <10>(360|428) (362|200|61)
+ + + 3:   organism homeostasis metabolism variant [WBPhenotype:0000577] <17>(348|415) (351|198|60)
+ + 2:   organism metabolism processing variant [WBPhenotype:0000027] <24>(169|180) (176|83|25)
+ 1:   protein interaction variant [WBPhenotype:0001369] <3>(47|48) (48|21|9)
0:   protein protein interaction variant [WBPhenotype:0001370] <2>(47|48) (48|21|9)
- 1:   protein aggregation variant [WBPhenotype:0001405] <1>(42|47) (43|19|8)
- 1:   protein complex organization variant [WBPhenotype:0002132] <1>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Cysteine proteinases0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
UBC-like0Direct
JAB1/MPN domain0Direct
Cu,Zn superoxide dismutase-like0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
RING/U-box0Direct
14-3-3 protein0Direct
Chaperone J-domain4.447e-16Direct
Acid proteases0.000000000000912Direct
HSP20-like chaperones0.00000000002108Direct
Tubulin nucleotide-binding domain-like0.00000000008201Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000002255Direct
Tubulin C-terminal domain-like0.0000000003157Direct
B-box zinc-binding domain0.00000000103Direct
GroEL equatorial domain-like0.000000002343Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.000000002343Direct
GroEL-intermediate domain like0.000000002343Direct
Hect, E3 ligase catalytic domain0.000000002343Direct
Cyclophilin-like0.000000007746Direct
GroEL apical domain-like0.0000000211Direct
Actin-like ATPase domain0.00000003662Direct
Ubiquitin-like0.00000004122Direct
FKBP-like0.0000008718Direct
Galactose-binding domain-like0.000001012Direct
Activating enzymes of the ubiquitin-like proteins0.000001765Direct
WD40 repeat-like0.000011Direct
"Winged helix" DNA-binding domain0.00003747Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.00008168Direct
Sec1/munc18-like (SM) proteins0.0001324Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0001473Direct
MIT domain0.0002464Direct
ADC-like0.0002464Direct
WWE domain0.0002464Direct
Cdc48 domain 2-like0.0002464Direct
Cullin homology domain0.0004071Direct
Seven-hairpin glycosidases0.0004071Direct
UBA-like0.0006254Direct
Translation proteins0.0008811Direct
PYP-like sensor domain (PAS domain)0.0009595Direct
HSP40/DnaJ peptide-binding domain0.001062Inherited
Cullin repeat-like0.001912Inherited
Skp1 dimerisation domain-like0.02529Inherited
RNI-like0.7023Inherited
EF-hand0.9325Inherited
POZ domain1Inherited
F-box domain1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
RING finger domain, C3HC40Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Cu,Zn superoxide dismutase-like0Direct
14-3-3 protein0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
UBC-related0Direct
PDI-like0Direct
Pepsin-like0.00000000000000345Direct
Chaperone J-domain0.00000000000001284Direct
Ubiquitin carboxyl-terminal hydrolase, UCH0.000000000000241Direct
Papain-like0.000000000001088Direct
Tubulin, GTPase domain0.0000000005174Direct
Ubiquitin-related0.0000000005218Direct
Actin/HSP700.000000000552Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000008985Direct
Tubulin, C-terminal domain0.000000001955Direct
B-box zinc-binding domain0.000000006266Direct
Hect, E3 ligase catalytic domain0.000000007881Direct
Cyclophilin (peptidylprolyl isomerase)0.00000003984Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.00000006894Direct
Group II chaperonin (CCT, TRIC), ATPase domain0.00000006894Direct
HSP200.00000006894Direct
Extended PAW domain0.0000001062Direct
Group II chaperonin (CCT, TRIC), apical domain0.0000005467Direct
FKBP immunophilin/proline isomerase0.000002405Direct
Calmodulin-like0.000005393Direct
Proteasome subunits0.00000853Direct
Ubiquitin activating enzymes (UBA)0.00004357Direct
RecA protein-like (ATPase-domain)0.0002264Direct
Sec1/munc18-like (SM) proteins0.0002264Direct
SCF ubiquitin ligase complex WHB domain0.0002264Direct
Cullin repeat0.0002264Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0002885Direct
WWE domain0.0003636Direct
Cdc48 N-terminal domain-like0.0003636Direct
Cdc48 domain 2-like0.0003636Direct
MIT domain0.0003636Direct
Sm motif of small nuclear ribonucleoproteins, SNRNP0.0004749Direct
Clathrin adaptor core protein0.0006896Direct
Class I alpha-1;2-mannosidase, catalytic domain0.0006896Direct
Cullin homology domain0.0006896Direct
Elongation factors0.0008688Direct
WD40-repeat0.03158Inherited
Skp1 dimerisation domain-like0.03528Inherited
F-box domain0.6595Inherited
BTB/POZ domain1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
14-3-3 protein0Direct
Cu,Zn superoxide dismutase-like0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
JAB1/MPN domain0Direct
RING/U-box0Direct
UBC-like0Direct
Cysteine proteinases0Direct
Chaperone J-domain3.468e-16Direct
Acid proteases0.0000000000007155Direct
HSP20-like chaperones0.00000000001661Direct
Tubulin nucleotide-binding domain-like0.0000000000647Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000001781Direct
Tubulin C-terminal domain-like0.0000000002494Direct
B-box zinc-binding domain0.0000000008152Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.000000001858Direct
Hect, E3 ligase catalytic domain0.000000001858Direct
GroEL equatorial domain-like0.000000001858Direct
GroEL-intermediate domain like0.000000001858Direct
Cyclophilin-like0.000000006156Direct
GroEL apical domain-like0.00000001679Direct
Actin-like ATPase domain0.00000002918Direct
Ubiquitin-like0.00000003286Direct
FKBP-like0.0000007018Direct
Galactose-binding domain-like0.0000008146Direct
Activating enzymes of the ubiquitin-like proteins0.000001425Direct
WD40 repeat-like0.000008907Direct
"Winged helix" DNA-binding domain0.00003047Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.00006662Direct
Sec1/munc18-like (SM) proteins0.0001081Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0001204Direct
Cdc48 domain 2-like0.0002018Direct
ADC-like0.0002018Direct
MIT domain0.0002018Direct
WWE domain0.0002018Direct
Seven-hairpin glycosidases0.0003348Direct
Cullin homology domain0.0003348Direct
UBA-like0.0005162Direct
Translation proteins0.0007291Direct
PYP-like sensor domain (PAS domain)0.0007949Direct
HSP40/DnaJ peptide-binding domain0.0008805Direct
Translation proteins SH3-like domain0.0009511Direct
Cullin repeat-like0.001597Inherited
Skp1 dimerisation domain-like0.02203Inherited
RNI-like0.6819Inherited
EF-hand0.9203Inherited
POZ domain1Inherited
F-box domain1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.0000000000647Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.000000001685Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.000000001858Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.000000001858Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.000000001858Direct
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.00000003771Direct
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.0000008798Direct
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0.000002221Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.0001081Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0.0001081Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0001204Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.0001807Direct
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0.0003177Direct
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.0008805Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.01345Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.000000001858Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.000000001858Direct
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.00000008325Direct
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.0000001562Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.0001081Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0001204Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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