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Worm Phenotype (WP): protein protein interaction variant

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Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   Variant [WBPhenotype:0000886] <5>
+ + + + + 5:   physiology variant [WBPhenotype:0000519] <6>(490|567) (491|248|69)
+ + + + 4:   organism physiology variant [WBPhenotype:0000576] <10>(359|429) (362|200|61)
+ + + 3:   organism homeostasis metabolism variant [WBPhenotype:0000577] <17>(347|416) (351|198|60)
+ + 2:   organism metabolism processing variant [WBPhenotype:0000027] <24>(170|181) (176|83|25)
+ 1:   protein interaction variant [WBPhenotype:0001369] <3>(47|48) (48|21|9)
0:   protein protein interaction variant [WBPhenotype:0001370] <2>(47|48) (48|21|9)
- 1:   protein aggregation variant [WBPhenotype:0001405] <1>(42|47) (43|19|8)
- 1:   protein complex organization variant [WBPhenotype:0002132] <1>(0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Cysteine proteinases0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
JAB1/MPN domain0Direct
RING/U-box0Direct
Cu,Zn superoxide dismutase-like0Direct
UBC-like0Direct
14-3-3 protein0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Chaperone J-domain4.457e-16Direct
Acid proteases0.0000000000008925Direct
HSP20-like chaperones0.00000000002066Direct
Tubulin nucleotide-binding domain-like0.00000000008067Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000002226Direct
Tubulin C-terminal domain-like0.0000000003104Direct
B-box zinc-binding domain0.000000001013Direct
GroEL-intermediate domain like0.000000002316Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.000000002316Direct
Hect, E3 ligase catalytic domain0.000000002316Direct
GroEL equatorial domain-like0.000000002316Direct
Cyclophilin-like0.000000007634Direct
GroEL apical domain-like0.00000002086Direct
Actin-like ATPase domain0.00000003591Direct
Ubiquitin-like0.00000004008Direct
FKBP-like0.000000864Direct
Galactose-binding domain-like0.0000009938Direct
Activating enzymes of the ubiquitin-like proteins0.000001752Direct
WD40 repeat-like0.00001068Direct
"Winged helix" DNA-binding domain0.00002099Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.00008077Direct
Sec1/munc18-like (SM) proteins0.0001315Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0001463Direct
Cdc48 domain 2-like0.0002453Direct
WWE domain0.0002453Direct
MIT domain0.0002453Direct
ADC-like0.0002453Direct
Cullin homology domain0.0004047Direct
Seven-hairpin glycosidases0.0004047Direct
UBA-like0.0006192Direct
Translation proteins0.0008722Direct
PYP-like sensor domain (PAS domain)0.0009535Direct
HSP40/DnaJ peptide-binding domain0.001058Inherited
Cullin repeat-like0.0019Inherited
Skp1 dimerisation domain-like0.02514Inherited
RNI-like0.7019Inherited
EF-hand0.9318Inherited
POZ domain1Inherited
F-box domain1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
14-3-3 protein0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
UBC-related0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
RING finger domain, C3HC40Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
Cu,Zn superoxide dismutase-like0Direct
PDI-like0Direct
Pepsin-like0.000000000000003141Direct
Chaperone J-domain0.00000000000001255Direct
Ubiquitin carboxyl-terminal hydrolase, UCH0.0000000000002337Direct
Papain-like0.000000000001054Direct
Tubulin, GTPase domain0.0000000005065Direct
Ubiquitin-related0.0000000005073Direct
Actin/HSP700.000000000538Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000008837Direct
Tubulin, C-terminal domain0.000000001914Direct
B-box zinc-binding domain0.000000006134Direct
HSP200.000000007763Direct
Hect, E3 ligase catalytic domain0.000000007763Direct
Cyclophilin (peptidylprolyl isomerase)0.00000003908Direct
Group II chaperonin (CCT, TRIC), ATPase domain0.00000006805Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.00000006805Direct
Extended PAW domain0.0000001043Direct
Group II chaperonin (CCT, TRIC), apical domain0.0000005403Direct
FKBP immunophilin/proline isomerase0.000002374Direct
Calmodulin-like0.000005263Direct
Proteasome subunits0.000008419Direct
Ubiquitin activating enzymes (UBA)0.0000432Direct
Cullin repeat0.0002246Direct
Sec1/munc18-like (SM) proteins0.0002246Direct
RecA protein-like (ATPase-domain)0.0002246Direct
SCF ubiquitin ligase complex WHB domain0.0002246Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0002858Direct
MIT domain0.0003614Direct
Cdc48 domain 2-like0.0003614Direct
WWE domain0.0003614Direct
Cdc48 N-terminal domain-like0.0003614Direct
Sm motif of small nuclear ribonucleoproteins, SNRNP0.0004697Direct
Clathrin adaptor core protein0.0006841Direct
Cullin homology domain0.0006841Direct
Class I alpha-1;2-mannosidase, catalytic domain0.0006841Direct
Elongation factors0.0008588Direct
WD40-repeat0.0311Inherited
Skp1 dimerisation domain-like0.03503Inherited
F-box domain0.658Inherited
BTB/POZ domain1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
UBC-like0Direct
RING/U-box0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Cysteine proteinases0Direct
JAB1/MPN domain0Direct
Cu,Zn superoxide dismutase-like0Direct
14-3-3 protein0Direct
Chaperone J-domain3.468e-16Direct
Acid proteases0.0000000000006984Direct
HSP20-like chaperones0.00000000001624Direct
Tubulin nucleotide-binding domain-like0.00000000006349Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000001754Direct
Tubulin C-terminal domain-like0.0000000002447Direct
B-box zinc-binding domain0.0000000008Direct
Hect, E3 ligase catalytic domain0.000000001833Direct
GroEL equatorial domain-like0.000000001833Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.000000001833Direct
GroEL-intermediate domain like0.000000001833Direct
Cyclophilin-like0.000000006053Direct
GroEL apical domain-like0.00000001657Direct
Actin-like ATPase domain0.00000002857Direct
Ubiquitin-like0.00000003189Direct
FKBP-like0.0000006941Direct
Galactose-binding domain-like0.0000007988Direct
Activating enzymes of the ubiquitin-like proteins0.000001412Direct
WD40 repeat-like0.000008639Direct
"Winged helix" DNA-binding domain0.00001702Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.00006577Direct
Sec1/munc18-like (SM) proteins0.0001073Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0001195Direct
MIT domain0.0002007Direct
Cdc48 domain 2-like0.0002007Direct
WWE domain0.0002007Direct
ADC-like0.0002007Direct
Seven-hairpin glycosidases0.0003325Direct
Cullin homology domain0.0003325Direct
UBA-like0.0005105Direct
Translation proteins0.000721Direct
PYP-like sensor domain (PAS domain)0.0007891Direct
HSP40/DnaJ peptide-binding domain0.0008759Direct
Translation proteins SH3-like domain0.0009441Direct
Cullin repeat-like0.001586Inherited
Skp1 dimerisation domain-like0.02189Inherited
RNI-like0.6813Inherited
EF-hand0.9198Inherited
POZ domain1Inherited
F-box domain1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.00000000006349Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.000000001646Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.000000001833Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.000000001833Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.000000001833Direct
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.00000003719Direct
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0.000002195Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0.0001073Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.0001073Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0001195Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.0001789Direct
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0.0003147Direct
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.0007891Direct
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.0008759Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.01337Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.000000001833Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.000000001833Direct
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.0000000822Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.0001073Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0001195Direct
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.0002007Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)