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Worm Phenotype (WP): protein aggregation variant

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + + 7:   Variant [WBPhenotype:0000886] <5>
+ + + + + + 6:   physiology variant [WBPhenotype:0000519] <6>(495|573) (496|248|69)
+ + + + + 5:   organism physiology variant [WBPhenotype:0000576] <10>(360|428) (362|200|61)
+ + + + 4:   organism homeostasis metabolism variant [WBPhenotype:0000577] <17>(348|415) (351|198|60)
+ + + 3:   organism metabolism processing variant [WBPhenotype:0000027] <24>(169|180) (176|83|25)
+ + 2:   protein interaction variant [WBPhenotype:0001369] <3>(47|48) (48|21|9)
+ 1:   protein protein interaction variant [WBPhenotype:0001370] <2>(47|48) (48|21|9)
0:   protein aggregation variant [WBPhenotype:0001405] <1>(42|47) (43|19|8)
- 1:   protein aggregation induced behavior variant [WBPhenotype:0002425] <3>(9|9) (9|3|1)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
RING/U-box0Direct
Cu,Zn superoxide dismutase-like0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Chaperone J-domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
UBC-like0Direct
JAB1/MPN domain0Direct
Acid proteases0.0000000000006337Direct
HSP20-like chaperones0.00000000001501Direct
Tubulin nucleotide-binding domain-like0.00000000006189Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000001806Direct
Tubulin C-terminal domain-like0.0000000002387Direct
B-box zinc-binding domain0.0000000007808Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.000000001921Direct
Hect, E3 ligase catalytic domain0.000000001921Direct
Cyclophilin-like0.000000006011Direct
Ubiquitin-like0.00000002615Direct
Actin-like ATPase domain0.00000002629Direct
FKBP-like0.0000007347Direct
Galactose-binding domain-like0.0000007495Direct
Activating enzymes of the ubiquitin-like proteins0.000001518Direct
WD40 repeat-like0.000006885Direct
"Winged helix" DNA-binding domain0.00002604Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.0000667Direct
Sec1/munc18-like (SM) proteins0.0001191Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0001303Direct
EF-hand0.0001322Direct
Cdc48 domain 2-like0.0002263Direct
WWE domain0.0002263Direct
ADC-like0.0002263Direct
MIT domain0.0002263Direct
Cullin homology domain0.0003674Direct
Seven-hairpin glycosidases0.0003674Direct
UBA-like0.0005325Direct
Translation proteins0.0007503Direct
PYP-like sensor domain (PAS domain)0.0008674Direct
HSP40/DnaJ peptide-binding domain0.0009783Direct
Cullin repeat-like0.001735Inherited
Skp1 dimerisation domain-like0.02298Inherited
RNI-like0.6813Inherited
POZ domain1Inherited
F-box domain1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Cu,Zn superoxide dismutase-like0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
RING finger domain, C3HC40Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
PDI-like0Direct
UBC-related0Direct
Pepsin-like0.000000000000002197Direct
Chaperone J-domain0.00000000000000752Direct
Ubiquitin carboxyl-terminal hydrolase, UCH0.0000000000001542Direct
Papain-like0.0000000000006846Direct
Ubiquitin-related0.000000000348Direct
Tubulin, GTPase domain0.0000000003798Direct
Actin/HSP700.000000000382Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000007039Direct
Tubulin, C-terminal domain0.00000000144Direct
B-box zinc-binding domain0.00000000463Direct
Hect, E3 ligase catalytic domain0.000000006329Direct
Cyclophilin (peptidylprolyl isomerase)0.00000003017Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.00000005674Direct
Group II chaperonin (CCT, TRIC), ATPase domain0.00000005674Direct
HSP200.00000005674Direct
Extended PAW domain0.00000008064Direct
Group II chaperonin (CCT, TRIC), apical domain0.0000004517Direct
FKBP immunophilin/proline isomerase0.000001993Direct
Calmodulin-like0.0000038Direct
Proteasome subunits0.000006969Direct
Ubiquitin activating enzymes (UBA)0.00003865Direct
Sec1/munc18-like (SM) proteins0.0002015Direct
Cullin repeat0.0002015Direct
RecA protein-like (ATPase-domain)0.0002015Direct
SCF ubiquitin ligase complex WHB domain0.0002015Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0002519Direct
Cdc48 N-terminal domain-like0.0003309Direct
Cdc48 domain 2-like0.0003309Direct
WWE domain0.0003309Direct
MIT domain0.0003309Direct
Sm motif of small nuclear ribonucleoproteins, SNRNP0.0004086Direct
Clathrin adaptor core protein0.000616Direct
Cullin homology domain0.000616Direct
Class I alpha-1;2-mannosidase, catalytic domain0.000616Direct
Elongation factors0.0007378Direct
WD40-repeat0.02507Inherited
Skp1 dimerisation domain-like0.03179Inherited
BTB/POZ domain0.3789Inherited
F-box domain0.6335Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
UBC-like0Direct
RING/U-box0Direct
JAB1/MPN domain0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Cu,Zn superoxide dismutase-like0Direct
Chaperone J-domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Acid proteases0.0000000000004969Direct
HSP20-like chaperones0.00000000001182Direct
Tubulin nucleotide-binding domain-like0.0000000000488Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000001426Direct
Tubulin C-terminal domain-like0.0000000001885Direct
B-box zinc-binding domain0.0000000006179Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.000000001523Direct
Hect, E3 ligase catalytic domain0.000000001523Direct
Cyclophilin-like0.000000004775Direct
Ubiquitin-like0.00000002082Direct
Actin-like ATPase domain0.00000002094Direct
FKBP-like0.0000005911Direct
Galactose-binding domain-like0.0000006031Direct
Activating enzymes of the ubiquitin-like proteins0.000001225Direct
WD40 repeat-like0.000005574Direct
"Winged helix" DNA-binding domain0.00002115Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.00005433Direct
Sec1/munc18-like (SM) proteins0.00009726Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0001064Direct
EF-hand0.0001079Direct
MIT domain0.0001851Direct
Cdc48 domain 2-like0.0001851Direct
WWE domain0.0001851Direct
ADC-like0.0001851Direct
Cullin homology domain0.0003018Direct
Seven-hairpin glycosidases0.0003018Direct
UBA-like0.0004388Direct
Translation proteins0.0006204Direct
PYP-like sensor domain (PAS domain)0.0007175Direct
HSP40/DnaJ peptide-binding domain0.0008106Direct
Translation proteins SH3-like domain0.0008461Direct
Cullin repeat-like0.001447Inherited
Skp1 dimerisation domain-like0.01999Inherited
RNI-like0.6602Inherited
POZ domain1Inherited
F-box domain1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.0000000000488Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.000000001194Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.000000001523Direct
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.00000003043Direct
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.000000728Direct
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0.000001842Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0.00009726Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.00009726Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0001064Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.0001548Direct
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0.0002767Direct
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.0008106Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.01215Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.000000001523Direct
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.00000006858Direct
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.0000001313Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.00009726Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0001064Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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