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Worm Phenotype (WP): protein aggregation variant

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + + 7:   Variant [WBPhenotype:0000886] <2>
+ + + + + + 6:   physiology variant [WBPhenotype:0000519] <14>(510|587) (510|248|69)
+ + + + + 5:   organism physiology variant [WBPhenotype:0000576] <9>(369|431) (372|193|57)
+ + + + 4:   organism homeostasis metabolism variant [WBPhenotype:0000577] <16>(361|421) (363|190|56)
+ + + 3:   organism metabolism processing variant [WBPhenotype:0000027] <25>(178|190) (182|87|26)
+ + 2:   protein interaction variant [WBPhenotype:0001369] <4>(47|49) (48|21|9)
+ 1:   protein protein interaction variant [WBPhenotype:0001370] <2>(44|49) (45|19|8)
0:   protein aggregation variant [WBPhenotype:0001405] <1>(43|48) (44|19|8)
- 1:   protein aggregation induced behavior variant [WBPhenotype:0002425] <3>(9|10) (9|3|1)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
JAB1/MPN domain0Direct
Cu,Zn superoxide dismutase-like0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
RING/U-box0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Chaperone J-domain0Direct
UBC-like0Direct
Cysteine proteinases0Direct
Acid proteases0.0000000000004016Direct
HSP20-like chaperones0.00000000001526Direct
Tubulin nucleotide-binding domain-like0.00000000006282Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000001831Direct
Tubulin C-terminal domain-like0.000000000242Direct
B-box zinc-binding domain0.000000000792Direct
Hect, E3 ligase catalytic domain0.000000001948Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.000000001948Direct
Cyclophilin-like0.000000006096Direct
Actin-like ATPase domain0.00000002668Direct
Ubiquitin-like0.0000001226Direct
FKBP-like0.0000007432Direct
Galactose-binding domain-like0.000001458Direct
Activating enzymes of the ubiquitin-like proteins0.000001534Direct
WD40 repeat-like0.00001911Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.00006709Direct
"Winged helix" DNA-binding domain0.00008138Direct
EF-hand0.0001133Direct
Sec1/munc18-like (SM) proteins0.0001196Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0001308Direct
MIT domain0.0002272Direct
WWE domain0.0002272Direct
ADC-like0.0002272Direct
Cdc48 domain 2-like0.0002272Direct
Seven-hairpin glycosidases0.0003691Direct
Cullin homology domain0.0003691Direct
UBA-like0.0005335Direct
Translation proteins0.000753Direct
PYP-like sensor domain (PAS domain)0.00087Direct
HSP40/DnaJ peptide-binding domain0.0009806Direct
Cullin repeat-like0.001736Inherited
Skp1 dimerisation domain-like0.02282Inherited
RNI-like0.6506Inherited
F-box domain0.9848Inherited
POZ domain1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
Cu,Zn superoxide dismutase-like0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
UBC-related0Direct
RING finger domain, C3HC40Direct
PDI-like0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Chaperone J-domain0.000000000000007816Direct
Pepsin-like0.00000000000001998Direct
Papain-like0.0000000000007105Direct
Ubiquitin carboxyl-terminal hydrolase, UCH0.00000000002292Direct
Tubulin, GTPase domain0.0000000003897Direct
Actin/HSP700.000000000394Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000007182Direct
Tubulin, C-terminal domain0.000000001477Direct
Ubiquitin-related0.000000004026Direct
B-box zinc-binding domain0.000000004746Direct
Hect, E3 ligase catalytic domain0.000000006444Direct
Cyclophilin (peptidylprolyl isomerase)0.00000003083Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.00000005756Direct
HSP200.00000005756Direct
Group II chaperonin (CCT, TRIC), ATPase domain0.00000005756Direct
Extended PAW domain0.0000000685Direct
Group II chaperonin (CCT, TRIC), apical domain0.0000004576Direct
FKBP immunophilin/proline isomerase0.000002018Direct
Proteasome subunits0.000007055Direct
Calmodulin-like0.0000131Direct
Ubiquitin activating enzymes (UBA)0.00003889Direct
Cullin repeat0.0002021Direct
Sec1/munc18-like (SM) proteins0.0002021Direct
SCF ubiquitin ligase complex WHB domain0.0002021Direct
RecA protein-like (ATPase-domain)0.0002021Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0002532Direct
Cdc48 N-terminal domain-like0.0003308Direct
WWE domain0.0003308Direct
MIT domain0.0003308Direct
Cdc48 domain 2-like0.0003308Direct
Sm motif of small nuclear ribonucleoproteins, SNRNP0.0004106Direct
Clathrin adaptor core protein0.000617Direct
Cullin homology domain0.000617Direct
Class I alpha-1;2-mannosidase, catalytic domain0.000617Direct
Elongation factors0.0007424Direct
WD40-repeat0.02516Inherited
Skp1 dimerisation domain-like0.03156Inherited
Thioltransferase0.09667Inherited
BTB/POZ domain0.3903Inherited
F-box domain0.5992Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Cu,Zn superoxide dismutase-like0Direct
Chaperone J-domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
UBC-like0Direct
Cysteine proteinases0Direct
RING/U-box0Direct
JAB1/MPN domain0Direct
Acid proteases0.0000000000003157Direct
HSP20-like chaperones0.00000000001204Direct
Tubulin nucleotide-binding domain-like0.00000000004965Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000001449Direct
Tubulin C-terminal domain-like0.0000000001917Direct
B-box zinc-binding domain0.0000000006283Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.000000001547Direct
Hect, E3 ligase catalytic domain0.000000001547Direct
Cyclophilin-like0.000000004854Direct
Actin-like ATPase domain0.0000000213Direct
Ubiquitin-like0.00000009822Direct
FKBP-like0.0000005995Direct
Galactose-binding domain-like0.000001179Direct
Activating enzymes of the ubiquitin-like proteins0.000001241Direct
WD40 repeat-like0.00001558Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.00005486Direct
"Winged helix" DNA-binding domain0.0000666Direct
EF-hand0.00009287Direct
Sec1/munc18-like (SM) proteins0.00009804Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0001073Direct
Cdc48 domain 2-like0.0001867Direct
MIT domain0.0001867Direct
WWE domain0.0001867Direct
ADC-like0.0001867Direct
Cullin homology domain0.0003042Direct
Seven-hairpin glycosidases0.0003042Direct
UBA-like0.0004415Direct
Translation proteins0.0006255Direct
PYP-like sensor domain (PAS domain)0.0007236Direct
HSP40/DnaJ peptide-binding domain0.0008157Direct
Translation proteins SH3-like domain0.0008523Direct
Cullin repeat-like0.001452Inherited
Skp1 dimerisation domain-like0.0199Inherited
RNI-like0.6291Inherited
F-box domain0.9739Inherited
POZ domain1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.00000000004965Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.000000001216Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.000000001547Direct
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.00000003093Direct
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0.000001868Direct
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.00001251Direct
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0.00007971Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.00009804Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0.00009804Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0001073Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.0001564Direct
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.0008157Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.01213Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.000000001547Direct
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.0000000697Direct
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.000004995Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.00009804Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0001073Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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