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Worm Phenotype (WP): protein aggregation variant

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + + 7:   Variant [WBPhenotype:0000886] <5>
+ + + + + + 6:   physiology variant [WBPhenotype:0000519] <7>(494|573) (495|248|68)
+ + + + + 5:   organism physiology variant [WBPhenotype:0000576] <10>(354|423) (357|200|60)
+ + + + 4:   organism homeostasis metabolism variant [WBPhenotype:0000577] <17>(343|412) (348|198|59)
+ + + 3:   organism metabolism processing variant [WBPhenotype:0000027] <25>(167|178) (172|81|24)
+ + 2:   protein interaction variant [WBPhenotype:0001369] <3>(48|48) (48|21|9)
+ 1:   protein protein interaction variant [WBPhenotype:0001370] <2>(48|48) (48|21|9)
0:   protein aggregation variant [WBPhenotype:0001405] <1>(43|47) (43|19|8)
- 1:   protein aggregation induced behavior variant [WBPhenotype:0002425] <3>(9|9) (9|3|1)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
RING/U-box0Direct
Chaperone J-domain0Direct
JAB1/MPN domain0Direct
Cu,Zn superoxide dismutase-like0Direct
UBC-like0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Acid proteases0.000000000000557Direct
HSP20-like chaperones0.00000000001333Direct
Tubulin nucleotide-binding domain-like0.00000000005644Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000001693Direct
Tubulin C-terminal domain-like0.0000000002177Direct
B-box zinc-binding domain0.0000000002177Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.000000001819Direct
Hect, E3 ligase catalytic domain0.000000001819Direct
Cyclophilin-like0.000000005545Direct
Actin-like ATPase domain0.00000002332Direct
Ubiquitin-like0.0000001024Direct
Galactose-binding domain-like0.0000006762Direct
FKBP-like0.0000007034Direct
Activating enzymes of the ubiquitin-like proteins0.000001465Direct
WD40 repeat-like0.00001582Direct
"Winged helix" DNA-binding domain0.00002264Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.00006243Direct
EF-hand0.0001164Direct
Sec1/munc18-like (SM) proteins0.0001167Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0001266Direct
WWE domain0.0002234Direct
MIT domain0.0002234Direct
ADC-like0.0002234Direct
Cdc48 domain 2-like0.0002234Direct
Cullin homology domain0.000359Direct
Seven-hairpin glycosidases0.000359Direct
UBA-like0.0005056Direct
Translation proteins0.0007128Direct
PYP-like sensor domain (PAS domain)0.0008458Direct
HSP40/DnaJ peptide-binding domain0.0009612Direct
Translation proteins SH3-like domain0.0009885Direct
Cullin repeat-like0.00169Inherited
Skp1 dimerisation domain-like0.02211Inherited
RNI-like0.6486Inherited
POZ domain1Inherited
F-box domain1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
UBC-related0Direct
RING finger domain, C3HC40Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
PDI-like0Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
Cu,Zn superoxide dismutase-like0Direct
Pepsin-like0.000000000000001938Direct
Chaperone J-domain0.000000000000006447Direct
Ubiquitin carboxyl-terminal hydrolase, UCH0.0000000000001356Direct
Papain-like0.0000000000005978Direct
Actin/HSP700.0000000003451Direct
Tubulin, GTPase domain0.0000000003502Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.000000000664Direct
Tubulin, C-terminal domain0.000000001329Direct
B-box zinc-binding domain0.000000001329Direct
Ubiquitin-related0.000000003511Direct
Hect, E3 ligase catalytic domain0.000000006024Direct
Cyclophilin (peptidylprolyl isomerase)0.00000002811Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.00000005447Direct
Group II chaperonin (CCT, TRIC), ATPase domain0.00000005447Direct
HSP200.00000005447Direct
Extended PAW domain0.00000007525Direct
Group II chaperonin (CCT, TRIC), apical domain0.0000004339Direct
FKBP immunophilin/proline isomerase0.000001914Direct
Calmodulin-like0.000003438Direct
Proteasome subunits0.000006645Direct
Ubiquitin activating enzymes (UBA)0.00003797Direct
Cullin repeat0.0001979Direct
RecA protein-like (ATPase-domain)0.0001979Direct
Sec1/munc18-like (SM) proteins0.0001979Direct
SCF ubiquitin ligase complex WHB domain0.0001979Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0002455Direct
WWE domain0.000327Direct
Cdc48 N-terminal domain-like0.000327Direct
Cdc48 domain 2-like0.000327Direct
MIT domain0.000327Direct
Sm motif of small nuclear ribonucleoproteins, SNRNP0.0003959Direct
Cullin homology domain0.0006046Direct
Clathrin adaptor core protein0.0006046Direct
Class I alpha-1;2-mannosidase, catalytic domain0.0006046Direct
Elongation factors0.0007112Direct
WD40-repeat0.02318Inherited
Skp1 dimerisation domain-like0.03071Inherited
BTB/POZ domain0.3667Inherited
F-box domain0.6181Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Cu,Zn superoxide dismutase-like0Direct
Chaperone J-domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
JAB1/MPN domain0Direct
RING/U-box0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
UBC-like0Direct
Acid proteases0.0000000000004344Direct
HSP20-like chaperones0.00000000001044Direct
Tubulin nucleotide-binding domain-like0.00000000004426Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000001331Direct
B-box zinc-binding domain0.0000000001712Direct
Tubulin C-terminal domain-like0.0000000001712Direct
Hect, E3 ligase catalytic domain0.000000001435Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.000000001435Direct
Cyclophilin-like0.000000004385Direct
Actin-like ATPase domain0.00000001851Direct
Ubiquitin-like0.00000008143Direct
Galactose-binding domain-like0.0000005418Direct
FKBP-like0.0000005637Direct
Activating enzymes of the ubiquitin-like proteins0.000001177Direct
WD40 repeat-like0.00001281Direct
"Winged helix" DNA-binding domain0.00001835Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.00005075Direct
EF-hand0.00009501Direct
Sec1/munc18-like (SM) proteins0.00009517Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0001033Direct
Cdc48 domain 2-like0.0001826Direct
ADC-like0.0001826Direct
WWE domain0.0001826Direct
MIT domain0.0001826Direct
Seven-hairpin glycosidases0.0002943Direct
Cullin homology domain0.0002943Direct
UBA-like0.0004159Direct
Translation proteins0.0005878Direct
PYP-like sensor domain (PAS domain)0.0006989Direct
HSP40/DnaJ peptide-binding domain0.0007951Direct
Translation proteins SH3-like domain0.0008175Direct
Cullin repeat-like0.001406Inherited
Skp1 dimerisation domain-like0.01917Inherited
RNI-like0.6264Inherited
F-box domain0.9928Inherited
POZ domain1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.00000000004426Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.000000001052Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.000000001435Direct
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.00000002845Direct
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0.0000006883Direct
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.00001178Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0.00009517Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.00009517Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0001033Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.0001481Direct
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0.0002662Direct
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.0007951Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.01167Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.000000001435Direct
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.00000006475Direct
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.000004754Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.00009517Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0001033Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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