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Worm Phenotype (WP): protein aggregation variant

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + + 7:   Variant [WBPhenotype:0000886] <5>
+ + + + + + 6:   physiology variant [WBPhenotype:0000519] <6>(490|567) (491|248|69)
+ + + + + 5:   organism physiology variant [WBPhenotype:0000576] <10>(359|429) (362|200|61)
+ + + + 4:   organism homeostasis metabolism variant [WBPhenotype:0000577] <17>(347|416) (351|198|60)
+ + + 3:   organism metabolism processing variant [WBPhenotype:0000027] <24>(170|181) (176|83|25)
+ + 2:   protein interaction variant [WBPhenotype:0001369] <3>(47|48) (48|21|9)
+ 1:   protein protein interaction variant [WBPhenotype:0001370] <2>(47|48) (48|21|9)
0:   protein aggregation variant [WBPhenotype:0001405] <1>(42|47) (43|19|8)
- 1:   protein aggregation induced behavior variant [WBPhenotype:0002425] <3>(9|9) (9|3|1)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
JAB1/MPN domain0Direct
RING/U-box0Direct
Cu,Zn superoxide dismutase-like0Direct
UBC-like0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Chaperone J-domain0Direct
Acid proteases0.0000000000006192Direct
HSP20-like chaperones0.00000000001469Direct
Tubulin nucleotide-binding domain-like0.00000000006077Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000001781Direct
Tubulin C-terminal domain-like0.0000000002344Direct
B-box zinc-binding domain0.0000000007669Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.000000001897Direct
Hect, E3 ligase catalytic domain0.000000001897Direct
Cyclophilin-like0.000000005916Direct
Ubiquitin-like0.00000002534Direct
Actin-like ATPase domain0.00000002571Direct
FKBP-like0.0000007275Direct
Galactose-binding domain-like0.0000007352Direct
Activating enzymes of the ubiquitin-like proteins0.000001505Direct
WD40 repeat-like0.000006668Direct
"Winged helix" DNA-binding domain0.00001445Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.00006584Direct
EF-hand0.00011Direct
Sec1/munc18-like (SM) proteins0.0001183Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0001293Direct
Cdc48 domain 2-like0.0002251Direct
WWE domain0.0002251Direct
MIT domain0.0002251Direct
ADC-like0.0002251Direct
Cullin homology domain0.0003649Direct
Seven-hairpin glycosidases0.0003649Direct
UBA-like0.0005261Direct
Translation proteins0.0007431Direct
PYP-like sensor domain (PAS domain)0.0008617Direct
HSP40/DnaJ peptide-binding domain0.0009733Direct
Cullin repeat-like0.001723Inherited
Skp1 dimerisation domain-like0.02284Inherited
RNI-like0.6804Inherited
POZ domain1Inherited
F-box domain1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
UBC-related0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
RING finger domain, C3HC40Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
Cu,Zn superoxide dismutase-like0Direct
PDI-like0Direct
Pepsin-like0.0000000000000022Direct
Chaperone J-domain0.000000000000007217Direct
Ubiquitin carboxyl-terminal hydrolase, UCH0.0000000000001488Direct
Papain-like0.0000000000006612Direct
Ubiquitin-related0.0000000003376Direct
Tubulin, GTPase domain0.0000000003711Direct
Actin/HSP700.0000000003716Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000006914Direct
Tubulin, C-terminal domain0.000000001407Direct
B-box zinc-binding domain0.000000004526Direct
HSP200.000000006227Direct
Hect, E3 ligase catalytic domain0.000000006227Direct
Cyclophilin (peptidylprolyl isomerase)0.00000002954Direct
Group II chaperonin (CCT, TRIC), ATPase domain0.00000005596Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.00000005596Direct
Extended PAW domain0.00000007906Direct
Group II chaperonin (CCT, TRIC), apical domain0.0000004458Direct
FKBP immunophilin/proline isomerase0.000001966Direct
Calmodulin-like0.000003701Direct
Proteasome subunits0.000006867Direct
Ubiquitin activating enzymes (UBA)0.00003833Direct
Cullin repeat0.0001998Direct
Sec1/munc18-like (SM) proteins0.0001998Direct
RecA protein-like (ATPase-domain)0.0001998Direct
SCF ubiquitin ligase complex WHB domain0.0001998Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0002495Direct
MIT domain0.0003286Direct
Cdc48 domain 2-like0.0003286Direct
WWE domain0.0003286Direct
Cdc48 N-terminal domain-like0.0003286Direct
Sm motif of small nuclear ribonucleoproteins, SNRNP0.0004042Direct
Clathrin adaptor core protein0.000611Direct
Cullin homology domain0.000611Direct
Class I alpha-1;2-mannosidase, catalytic domain0.000611Direct
Elongation factors0.0007287Direct
WD40-repeat0.02463Inherited
Skp1 dimerisation domain-like0.03157Inherited
BTB/POZ domain0.3767Inherited
F-box domain0.6314Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
UBC-like0Direct
RING/U-box0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Chaperone J-domain0Direct
JAB1/MPN domain0Direct
Cu,Zn superoxide dismutase-like0Direct
Acid proteases0.0000000000004842Direct
HSP20-like chaperones0.00000000001153Direct
Tubulin nucleotide-binding domain-like0.0000000000478Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000001404Direct
Tubulin C-terminal domain-like0.0000000001848Direct
B-box zinc-binding domain0.0000000006056Direct
Hect, E3 ligase catalytic domain0.000000001501Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.000000001501Direct
Cyclophilin-like0.000000004688Direct
Ubiquitin-like0.00000002015Direct
Actin-like ATPase domain0.00000002044Direct
FKBP-like0.0000005842Direct
Galactose-binding domain-like0.0000005905Direct
Activating enzymes of the ubiquitin-like proteins0.000001212Direct
WD40 repeat-like0.00000539Direct
"Winged helix" DNA-binding domain0.0000117Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.00005355Direct
EF-hand0.00008969Direct
Sec1/munc18-like (SM) proteins0.00009653Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0001055Direct
MIT domain0.000184Direct
Cdc48 domain 2-like0.000184Direct
WWE domain0.000184Direct
ADC-like0.000184Direct
Seven-hairpin glycosidases0.0002995Direct
Cullin homology domain0.0002995Direct
UBA-like0.0004333Direct
Translation proteins0.0006136Direct
PYP-like sensor domain (PAS domain)0.0007123Direct
HSP40/DnaJ peptide-binding domain0.0008056Direct
Translation proteins SH3-like domain0.0008392Direct
Cullin repeat-like0.001435Inherited
Skp1 dimerisation domain-like0.01985Inherited
RNI-like0.6589Inherited
POZ domain1Inherited
F-box domain1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.0000000000478Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.000000001165Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.000000001501Direct
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.00000002998Direct
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0.000001818Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0.00009653Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.00009653Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0001055Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.0001532Direct
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0.000274Direct
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.0007123Direct
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.0008056Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.01207Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.000000001501Direct
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.00000006764Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.00009653Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0001055Direct
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.000184Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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