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Worm Phenotype (WP): protein aggregation variant

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + + 7:   Variant [WBPhenotype:0000886] <2>
+ + + + + + 6:   physiology variant [WBPhenotype:0000519] <14>(510|587) (510|248|68)
+ + + + + 5:   organism physiology variant [WBPhenotype:0000576] <9>(369|431) (372|193|56)
+ + + + 4:   organism homeostasis metabolism variant [WBPhenotype:0000577] <16>(361|421) (363|190|55)
+ + + 3:   organism metabolism processing variant [WBPhenotype:0000027] <25>(178|190) (182|87|26)
+ + 2:   protein interaction variant [WBPhenotype:0001369] <4>(47|49) (48|21|9)
+ 1:   protein protein interaction variant [WBPhenotype:0001370] <2>(44|49) (45|19|8)
0:   protein aggregation variant [WBPhenotype:0001405] <1>(43|48) (44|19|8)
- 1:   protein aggregation induced behavior variant [WBPhenotype:0002425] <3>(9|10) (9|3|1)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
JAB1/MPN domain0Direct
UBC-like0Direct
RING/U-box0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Chaperone J-domain0Direct
Cysteine proteinases0Direct
Cu,Zn superoxide dismutase-like0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Acid proteases0.0000000000004116Direct
HSP20-like chaperones0.00000000001564Direct
Tubulin nucleotide-binding domain-like0.00000000006412Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000001861Direct
Tubulin C-terminal domain-like0.000000000247Direct
B-box zinc-binding domain0.000000000808Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.000000001976Direct
Hect, E3 ligase catalytic domain0.000000001976Direct
Cyclophilin-like0.000000006209Direct
Actin-like ATPase domain0.00000002733Direct
Ubiquitin-like0.0000001265Direct
FKBP-like0.0000007525Direct
Galactose-binding domain-like0.000001488Direct
Activating enzymes of the ubiquitin-like proteins0.00000155Direct
WD40 repeat-like0.00001974Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.00006807Direct
"Winged helix" DNA-binding domain0.00008342Direct
EF-hand0.0001161Direct
Sec1/munc18-like (SM) proteins0.0001205Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.000132Direct
ADC-like0.0002287Direct
WWE domain0.0002287Direct
Cdc48 domain 2-like0.0002287Direct
MIT domain0.0002287Direct
Cullin homology domain0.0003718Direct
Seven-hairpin glycosidases0.0003718Direct
UBA-like0.0005398Direct
Translation proteins0.000762Direct
PYP-like sensor domain (PAS domain)0.0008764Direct
HSP40/DnaJ peptide-binding domain0.0009864Direct
Cullin repeat-like0.001748Inherited
Skp1 dimerisation domain-like0.02297Inherited
RNI-like0.6523Inherited
F-box domain0.9854Inherited
POZ domain1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
PDI-like0Direct
UBC-related0Direct
Cu,Zn superoxide dismutase-like0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
RING finger domain, C3HC40Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Chaperone J-domain0.000000000000008126Direct
Pepsin-like0.0000000000000206Direct
Papain-like0.0000000000007302Direct
Ubiquitin carboxyl-terminal hydrolase, UCH0.00000000002346Direct
Tubulin, GTPase domain0.0000000003968Direct
Actin/HSP700.0000000004025Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000007286Direct
Tubulin, C-terminal domain0.000000001504Direct
Ubiquitin-related0.000000004117Direct
B-box zinc-binding domain0.000000004831Direct
Hect, E3 ligase catalytic domain0.000000006528Direct
Cyclophilin (peptidylprolyl isomerase)0.00000003134Direct
HSP200.00000005822Direct
Group II chaperonin (CCT, TRIC), ATPase domain0.00000005822Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.00000005822Direct
Extended PAW domain0.00000006954Direct
Group II chaperonin (CCT, TRIC), apical domain0.0000004627Direct
FKBP immunophilin/proline isomerase0.000002041Direct
Proteasome subunits0.000007141Direct
Calmodulin-like0.00001336Direct
Ubiquitin activating enzymes (UBA)0.00003916Direct
Cullin repeat0.0002035Direct
Sec1/munc18-like (SM) proteins0.0002035Direct
SCF ubiquitin ligase complex WHB domain0.0002035Direct
RecA protein-like (ATPase-domain)0.0002035Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0002551Direct
Cdc48 domain 2-like0.0003326Direct
WWE domain0.0003326Direct
MIT domain0.0003326Direct
Cdc48 N-terminal domain-like0.0003326Direct
Sm motif of small nuclear ribonucleoproteins, SNRNP0.0004142Direct
Clathrin adaptor core protein0.0006209Direct
Class I alpha-1;2-mannosidase, catalytic domain0.0006209Direct
Cullin homology domain0.0006209Direct
Elongation factors0.0007495Direct
WD40-repeat0.02552Inherited
Skp1 dimerisation domain-like0.03175Inherited
Thioltransferase0.09703Inherited
BTB/POZ domain0.3919Inherited
F-box domain0.6006Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
RING/U-box0Direct
Cysteine proteinases0Direct
Chaperone J-domain0Direct
JAB1/MPN domain0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
UBC-like0Direct
Cu,Zn superoxide dismutase-like0Direct
Acid proteases0.0000000000003238Direct
HSP20-like chaperones0.00000000001235Direct
Tubulin nucleotide-binding domain-like0.0000000000507Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000001474Direct
Tubulin C-terminal domain-like0.0000000001957Direct
B-box zinc-binding domain0.0000000006414Direct
Hect, E3 ligase catalytic domain0.000000001571Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.000000001571Direct
Cyclophilin-like0.000000004947Direct
Actin-like ATPase domain0.00000002183Direct
Ubiquitin-like0.0000001014Direct
FKBP-like0.0000006073Direct
Galactose-binding domain-like0.000001205Direct
Activating enzymes of the ubiquitin-like proteins0.000001255Direct
WD40 repeat-like0.0000161Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.00005568Direct
"Winged helix" DNA-binding domain0.0000683Direct
EF-hand0.00009519Direct
Sec1/munc18-like (SM) proteins0.00009882Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0001082Direct
Cdc48 domain 2-like0.000188Direct
MIT domain0.000188Direct
WWE domain0.000188Direct
ADC-like0.000188Direct
Cullin homology domain0.0003066Direct
Seven-hairpin glycosidases0.0003066Direct
UBA-like0.000447Direct
Translation proteins0.0006331Direct
PYP-like sensor domain (PAS domain)0.0007292Direct
HSP40/DnaJ peptide-binding domain0.0008209Direct
Translation proteins SH3-like domain0.0008598Direct
Cullin repeat-like0.001463Inherited
Skp1 dimerisation domain-like0.02005Inherited
RNI-like0.6308Inherited
F-box domain0.9744Inherited
POZ domain1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.0000000000507Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.000000001247Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.000000001571Direct
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.00000003143Direct
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0.000001895Direct
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.00001266Direct
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0.00008054Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0.00009882Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.00009882Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0001082Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.0001583Direct
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.0008209Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.01222Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.000000001571Direct
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.00000007071Direct
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.000005051Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.00009882Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0001082Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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