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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

• Disease Ontology (DO) Ontology (DO)
  DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
  
• Human Phenotype (HP) Ontology (HP)
  HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
  
• Mouse Phenotype (MP) Ontology (MP)
  MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
  
• Worm Phenotype (WP) Ontology (WP)
  WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
  
• Yeast Phenotype (YP) Ontology (YP)
  Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
  
• Fly Phenotype (FP) Ontology (FP)
  FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
  
• Fly Anatomy (FA) Ontology (FA)
  FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
  
• Zebrafish Anatomy (ZA) Ontology (ZA)
  ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
  
• Xenopus Anatomy (XA) Ontology (XA)
  XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
  
• Arabidopsis Plant Ontology (AP) Ontology (AP)
  As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
  
• Enzyme Commission (EC) Ontology (EC)
  Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
  
• DrugBank ATC (DB) Ontology (DB)
  In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
  
• UniProtKB KeyWords (KW) Ontology (KW)
  Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
  
• UniProtKB UniPathway (UP) Ontology (UP)
  UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
  

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
  

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
  

Superfamily domains annotated to this XA term (SDXA level: Least Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
GFP-like	0	DIRECT
Orange domain-like	0	DIRECT
SAP domain	0	DIRECT
MIR domain	0	DIRECT
Moesin tail domain	0	DIRECT
FMT C-terminal domain-like	0	DIRECT
eIF4e-like	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
SRF-like	0	DIRECT
4Fe-4S ferredoxins	0	DIRECT
DLC	0	DIRECT
TK C-terminal domain-like	0	DIRECT
GINS helical bundle-like	0	DIRECT
Ribosomal L27 protein-like	0	DIRECT
Isocitrate/Isopropylmalate dehydrogenase-like	0	DIRECT
GYF domain	0	DIRECT
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
Nucleoplasmin-like core domain	0	DIRECT
Aconitase iron-sulfur domain	0	DIRECT
Myosin phosphatase inhibitor 17kDa protein, CPI-17	0	DIRECT
ATP-dependent DNA ligase DNA-binding domain	0	DIRECT
PriA/YqbF domain	0	DIRECT
KA1-like	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
C-terminal domain of adenylylcyclase associated protein	0	DIRECT
ADP-ribosylglycohydrolase	0	DIRECT
BAG domain	0	DIRECT
Tim10-like	0	DIRECT
Subunits of heterodimeric actin filament capping protein Capz	0	DIRECT
Ribosomal proteins L15p and L18e	0	DIRECT
L-aspartase-like	0	DIRECT
alpha-ketoacid dehydrogenase kinase, N-terminal domain	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
PAH2 domain	0	DIRECT
SMAD MH1 domain	0	DIRECT
Delta-sleep-inducing peptide immunoreactive peptide	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Acyl-CoA dehydrogenase NM domain-like	0	DIRECT
Endosomal sorting complex assembly domain	0	DIRECT
FAS1 domain	0	DIRECT
BSD domain-like	0	DIRECT
PAP/OAS1 substrate-binding domain	0	DIRECT
NTF2-like	0	DIRECT
Trefoil	0	DIRECT
Apolipoprotein A-I	0	DIRECT
post-AAA+ oligomerization domain-like	0	DIRECT
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	0	DIRECT
Nop domain	0	DIRECT
Cryptochrome/photolyase FAD-binding domain	0	DIRECT
Troponin coil-coiled subunits	0	DIRECT
G protein-binding domain	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
Hedgehog/DD-peptidase	0	DIRECT
PLP-binding barrel	0	DIRECT
TAFH domain-like	0	DIRECT
Aminoacid dehydrogenase-like, N-terminal domain	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Acyl-CoA dehydrogenase C-terminal domain-like	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Translation proteins SH3-like domain	0	DIRECT
14-3-3 protein	0	DIRECT
PEBP-like	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
Class I glutamine amidotransferase-like	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
Sec63 N-terminal domain-like	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
Alpha-macroglobulin receptor domain	0	DIRECT
Mitochondrial cytochrome c oxidase subunit VIIa	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
NAP-like	0	DIRECT
Cryptochrome/photolyase, N-terminal domain	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Synuclein	0	DIRECT
Mib/herc2 domain-like	0	DIRECT
Soluble quinoprotein glucose dehydrogenase	0	DIRECT
Cytokine	0	DIRECT
Ribulose-phoshate binding barrel	0	DIRECT
Arginase/deacetylase	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
Cap-Gly domain	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
Ferritin-like	0	DIRECT
Zn-binding ribosomal proteins	0	DIRECT
Nucleoporin domain	0	DIRECT
Bromodomain	0	DIRECT
SIS domain	0	DIRECT
IP3 receptor type 1 binding core, domain 2	0	DIRECT
Proteasome activator	0	DIRECT
CoA-dependent acyltransferases	0	DIRECT
Mediator hinge subcomplex-like	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
alpha-catenin/vinculin-like	0	DIRECT
N-acetylmuramoyl-L-alanine amidase-like	0	DIRECT
WGR domain-like	0	DIRECT
Connexin43	0	DIRECT
Fibrinogen coiled-coil and central regions	0	DIRECT
E2F-DP heterodimerization region	0	DIRECT
HRDC-like	0	DIRECT
Di-copper centre-containing domain	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
SPOC domain-like	0	DIRECT
Clathrin adaptor appendage domain	0	DIRECT
Alanine racemase C-terminal domain-like	0	DIRECT
Notch domain	0	DIRECT
Uracil-DNA glycosylase-like	0	DIRECT
Ribosomal proteins S24e, L23 and L15e	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
BRK domain-like	0	DIRECT
LeuD/IlvD-like	0	DIRECT
FF domain	0	DIRECT
Subdomain of clathrin and coatomer appendage domain	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
LuxS/MPP-like metallohydrolase	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
DNA ligase/mRNA capping enzyme, catalytic domain	0	DIRECT
Homeodomain-like	0.000004158	DIRECT
RNA-binding domain, RBD	0.00001336	DIRECT
"Winged helix" DNA-binding domain	0.0001336	DIRECT
Nucleic acid-binding proteins	0.0002906	DIRECT
HLH, helix-loop-helix DNA-binding domain	0.0004101	DIRECT
Thioredoxin-like	0.01006	INHERITED FROM: skeletal tissue || early proximal tubule || connective tissue || bone tissue
UBC-like	0.0147	INHERITED FROM: bone tissue
Cyclin-like	0.0191	INHERITED FROM: postmigratory neural crest cell
SET domain	0.03623	INHERITED FROM: primary germ layer
Actin depolymerizing proteins	0.05129	INHERITED FROM: skeletal tissue || connective tissue || bone tissue
Eukaryotic type KH-domain (KH-domain type I)	0.05137	INHERITED FROM: primary germ layer
HSP20-like chaperones	0.05588	INHERITED FROM: skeletal muscle
HMG-box	0.05696	INHERITED FROM: cranial neural crest || endocardium || neural plate || blastocoel floor || neural crest || neural fold || midbrain-hindbrain boundary || neuroectoderm outer layer || endoderm || chordal neural plate || hyoid crest || retinal layer || pre-chordal neural plate || posterior branchial crest || optic field || anterior branchial crest || anterior neural fold || neural plate border || otic vesicle || neurogenic placode || neuroectoderm
Tubulin C-terminal domain-like	0.08651	INHERITED FROM: epidermal cell || epidermis || epithelial cell || gastrocoel roof plate || non-neural ectoderm || facial nerve || vagus nerve || trigeminal nerve || glossopharyngeal nerve || epithelium
Heat shock protein 70kD (HSP70), peptide-binding domain	0.09873	INHERITED FROM: skeletal muscle
GroEL equatorial domain-like	0.1191	INHERITED FROM: muscle || anterior dorsal lateral plate region || endomesoderm || skeletal muscle
Actin-like ATPase domain	0.12	INHERITED FROM: myocyte || jaw muscle || head somite || cranial muscle || skeletal muscle
p53-like transcription factors	0.1269	INHERITED FROM: myocardium || involuted ventral mesoderm || regenerating tissue || mesenchyme || cartilage tissue || neural plate || mesoderm || primary heart field || blastema || cranial placode || neurogenic placode || neuroectoderm || notochord
GroEL-intermediate domain like	0.1602	INHERITED FROM: muscle || anterior dorsal lateral plate region || endomesoderm || skeletal muscle
Second domain of FERM	0.1861	INHERITED FROM: nerve
Tubulin nucleotide-binding domain-like	0.2003	INHERITED FROM: epidermal cell || epidermis || epithelial cell || gastrocoel roof plate || non-neural ectoderm || facial nerve || vagus nerve || trigeminal nerve || glossopharyngeal nerve || epithelium
Spectrin repeat	0.2318	INHERITED FROM: auditory hair cell || epithelial cell || sensory epithelial cell
Translation proteins	0.2318	INHERITED FROM: ventral blood island
Transducin (alpha subunit), insertion domain	0.2333	INHERITED FROM: olfactory epithelium || olfactory sensory neuron
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.2549	INHERITED FROM: skeletal muscle
Hemopexin-like domain	0.2909	INHERITED FROM: mesodermal cell || fibroblast || notochord
GroEL apical domain-like	0.3163	INHERITED FROM: muscle || anterior dorsal lateral plate region || skeletal muscle
Myosin rod fragments	0.3387	INHERITED FROM: musculature of face
Frizzled cysteine-rich domain	0.3486	INHERITED FROM: presumptive paraxial mesoderm || presomitic mesoderm || somite || mesenchyme || neural plate || mesoderm || neural fold || midbrain-hindbrain boundary || endoderm || involuted dorsal mesoderm || pre-chordal neural plate || optic field || anterior neural fold || mouth primordium || tail tip || tail fin || stomodeal-hypophyseal primordium || lateral plate mesoderm || otic vesicle || neurogenic placode || neuroectoderm
Glucocorticoid receptor-like (DNA-binding domain)	0.3504	INHERITED FROM: anterior placodal area || post-anal gut || sensorial layer of neurectoderm || proximal tubule branch || cranial placode || zona limitans intrathalamica || preplacodal ectoderm || archenteron floor || neuroectoderm
Phosphoglycerate mutase-like	0.373	INHERITED FROM: mesenchyme || head mesenchyme
SMAD/FHA domain	0.3743	INHERITED FROM: endocardium
Annexin	0.3938	INHERITED FROM: bone tissue
LDH C-terminal domain-like	0.4007	INHERITED FROM: skeletal tissue || connective tissue || bone tissue
TSP type-3 repeat	0.4007	INHERITED FROM: epithelium
Cystine-knot cytokines	0.4565	INHERITED FROM: neural groove || regenerating tissue || foregut endoderm || involuting marginal zone mesenchymal layer || mesenchyme || head mesoderm || mesoderm || ventral mesoderm || head mesenchyme || endoderm || involuted dorsal mesoderm || primary heart field || blastema || mouth primordium || vegetal endoderm || secondary heart field || neurogenic placode || neuroectoderm || notochord
Thiolase-like	0.465	INHERITED FROM: skeletal muscle
lambda repressor-like DNA-binding domains	0.4994	INHERITED FROM: pronephric mesenchyme || pronephric tubule || proximal tubule || neural plate || neural fold || distal tubule || chordal neural plate || cranial placode || early distal tubule || late distal tubule || neurogenic placode || neuroectoderm
Kringle-like	0.5582	INHERITED FROM: neural groove || epithelium
Intermediate filament protein, coiled coil region	0.6032	INHERITED FROM: retinal ganglion cell layer || cranial nerve || spinal ganglion || vestibulocochlear nerve || epidermis || retinal inner plexiform layer || retinal ganglion cell || ganglion || retinal inner nuclear layer || nerve || retinal outer plexiform layer || optic nerve || epithelium
Globin-like	0.6311	INHERITED FROM: anterior dorsal lateral plate region || anterior ventral blood island || lateral plate mesoderm || ventral blood island
Growth factor receptor domain	0.6344	INHERITED FROM: mesenchyme || fin || proximal tubule || mesoderm || endoderm || tail tip || anterior neural ridge || hypochord || tail fin || otic vesicle || pre-chordal neural plate border || notochord
TIMP-like	0.6872	INHERITED FROM: endoderm || pre-chordal neural plate || optic field || stomodeal-hypophyseal primordium
Snake toxin-like	0.6907	INHERITED FROM: dorsal lateral plate mesoderm || anterior dorsal lateral plate region || mesenchyme || head mesoderm || neural plate || mesoderm || ventral mesoderm || head mesenchyme || involuted dorsal mesoderm || chordal neural plate || pre-chordal neural plate || lateral plate mesoderm || neuroectoderm
FnI-like domain	0.709	INHERITED FROM: somite || epithelial cell || endoderm || hypochord || notochord
Tropomyosin	0.7496	INHERITED FROM: myocardium || myotome || myocyte
Sema domain	0.7556	INHERITED FROM: cranial neural crest || otic placode || neural crest || midbrain-hindbrain boundary || involuted dorsal mesoderm || cranial placode || neuroectoderm
Protein kinase-like (PK-like)	0.7618	INHERITED FROM: regenerating hindlimb || head mesoderm || head mesenchyme
Integrin domains	0.8229	INHERITED FROM: mesodermal cell || fibroblast
Kazal-type serine protease inhibitors	0.8827	INHERITED FROM: neural groove || neural plate || hypochord || notochord
EGF/Laminin	0.9214	INHERITED FROM: neural groove || hypochord || notochord
PYP-like sensor domain (PAS domain)	0.9708	INHERITED FROM: somite || tail somite || trunk somite || epaxial muscle
Immunoglobulin	1	INHERITED FROM: retinal inner nuclear layer
beta-beta-alpha zinc fingers	1	INHERITED FROM: chordal neural plate border || neural fold || splanchnic layer of lateral plate mesoderm || chordal neural plate || pre-chordal neural plate || anterior neural ridge || pre-chordal neural plate border
Fibronectin type III	1	INHERITED FROM: retinal ganglion cell layer || retinal inner nuclear layer
TSP-1 type 1 repeat	1	INHERITED FROM: hypochord
Plexin repeat	1	INHERITED FROM: cranial neural crest || otic placode || neural crest || involuted dorsal mesoderm || cranial placode || neuroectoderm
Voltage-gated potassium channels	1	INHERITED FROM: retinal ganglion cell layer || cranial nerve || retinal inner plexiform layer || nerve || retinal outer plexiform layer || optic nerve
Metalloproteases ("zincins"), catalytic domain	1	INHERITED FROM: mesodermal cell || fibroblast
EF-hand	1	INHERITED FROM: myocyte
Family A G protein-coupled receptor-like	1	INHERITED FROM: granule cell layer of the olfactory bulb

Family domains annotated to this XA term (SDXA level: Least Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Prokaryotic proteases	0	DIRECT
Delta-sleep-inducing peptide immunoreactive peptide	0	DIRECT
RNA-polymerase beta-prime	0	DIRECT
Polo-box duplicated region	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
LeuD-like	0	DIRECT
Kinase associated domain 1, KA1	0	DIRECT
CAT-like	0	DIRECT
MIF4G domain-like	0	DIRECT
Phenylalanine metabolism regulatory domain	0	DIRECT
BSD domain	0	DIRECT
Translation initiation factor eIF4e	0	DIRECT
S-adenosylhomocystein hydrolase	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
Alpha-macroglobulin receptor domain	0	DIRECT
Adenain-like	0	DIRECT
Pumilio repeat	0	DIRECT
Arrestin/Vps26-like	0	DIRECT
GABARAP-like	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
Cryptochrome/photolyase, N-terminal domain	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain	0	DIRECT
Dimeric isocitrate & isopropylmalate dehydrogenases	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
IF2B-like	0	DIRECT
DNA ligase/mRNA capping enzyme postcatalytic domain	0	DIRECT
Ribosomal proteins L15p and L18e	0	DIRECT
Pseudouridine synthase I TruA	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
Trunk domain of Sec23/24	0	DIRECT
NIPSNAP	0	DIRECT
N-type ATP pyrophosphatases	0	DIRECT
HD domain	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
Ribonuclease PH domain 1-like	0	DIRECT
alpha-ketoacid dehydrogenase kinase, C-terminal domain	0	DIRECT
BAG domain	0	DIRECT
Alpha-adaptin ear subdomain-like	0	DIRECT
MHCK/EF2 kinase	0	DIRECT
Prefoldin	0	DIRECT
Trefoil	0	DIRECT
Hairy Orange domain	0	DIRECT
acyl-CoA oxidase C-terminal domains	0	DIRECT
Paired domain	0	DIRECT
Choline/Carnitine O-acyltransferase	0	DIRECT
Alanine racemase-like, N-terminal domain	0	DIRECT
Tim10/DDP	0	DIRECT
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
Notch domain	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
Cryptochrome/photolyase FAD-binding domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
gamma-adaptin C-terminal appendage domain-like	0	DIRECT
PAH2 domain	0	DIRECT
HAT/Suf repeat	0	DIRECT
Fibroblast growth factors (FGF)	0	DIRECT
ATP-dependent DNA ligase catalytic domain	0	DIRECT
Ran-binding domain	0	DIRECT
Cytidylyltransferase	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase Pyr module	0	DIRECT
Extracellular domain of cell surface receptors	0	DIRECT
Bromodomain	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Fibrinogen coiled-coil and central regions	0	DIRECT
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase PP module	0	DIRECT
SRF-like	0	DIRECT
DNA ligase	0	DIRECT
Class I glutamine amidotransferases (GAT)	0	DIRECT
Aconitase iron-sulfur domain	0	DIRECT
TRASH domain	0	DIRECT
NagB-like	0	DIRECT
NLI interacting factor-like phosphatase	0	DIRECT
Clathrin adaptor appendage, alpha and beta chain-specific domain	0	DIRECT
Cell cycle transcription factor e2f-dp	0	DIRECT
Class I aldolase	0	DIRECT
Phosphatidylethanolamine binding protein	0	DIRECT
WGR domain	0	DIRECT
SMAD domain	0	DIRECT
Serine carboxypeptidase-like	0	DIRECT
UBX domain	0	DIRECT
BRK domain-like	0	DIRECT
Guanido kinase catalytic domain	0	DIRECT
SMAD MH1 domain	0	DIRECT
DLC	0	DIRECT
Synuclein	0	DIRECT
MPP-like	0	DIRECT
SH3BGR (SH3-binding, glutamic acid-rich protein-like)	0	DIRECT
Troponin T	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
L domain	0	DIRECT
Histone deacetylase, HDAC	0	DIRECT
N-acetylmuramoyl-L-alanine amidase-like	0	DIRECT
Noncollagenous (NC1) domain of collagen IV	0	DIRECT
Sedlin (SEDL)	0	DIRECT
Nop domain	0	DIRECT
Apolipoprotein A-I	0	DIRECT
Phosphoribosylpyrophosphate synthetase-like	0	DIRECT
Nucleoplasmin-like core domain	0	DIRECT
SIAH, seven in absentia homolog	0	DIRECT
Domain G2 of nidogen-1	0	DIRECT
Heat-shock transcription factor	0	DIRECT
FF domain	0	DIRECT
FAS1 domain	0	DIRECT
Hedgehog (development protein), N-terminal signaling domain	0	DIRECT
NTF2-like	0	DIRECT
DNA polymerase III clamp loader subunits, C-terminal domain	0	DIRECT
LON domain-like	0	DIRECT
C-terminal domain of adenylylcyclase associated protein	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
Cap-Gly domain	0	DIRECT
IP3 receptor type 1 binding core, domain 2	0	DIRECT
Noggin	0	DIRECT
ZZ domain	0	DIRECT
14-3-3 protein	0	DIRECT
Cofilin-like	0	DIRECT
Moesin tail domain	0	DIRECT
HCDH C-domain-like	0	DIRECT
acyl-CoA oxidase N-terminal domains	0	DIRECT
Aminoacid dehydrogenase-like, C-terminal domain	0	DIRECT
Class II glutamine amidotransferases	0	DIRECT
Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	0	DIRECT
Mitochondrial cytochrome c oxidase subunit VIIa	0	DIRECT
TAFH domain-like	0	DIRECT
Eukaryotic ODC-like	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	0	DIRECT
RUNT domain	0	DIRECT
Ferritin	0	DIRECT
E2F dimerization segment	0	DIRECT
RNA-polymerase beta	0	DIRECT
ADP-ribosylglycohydrolase	0	DIRECT
TRAPP components	0	DIRECT
ets domain	0	DIRECT
Cystathionine synthase-like	0	DIRECT
Sm motif of small nuclear ribonucleoproteins, SNRNP	0	DIRECT
SAP domain	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain	0	DIRECT
Pointed domain	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
Hsp90 middle domain	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
Malic enzyme N-domain	0	DIRECT
alpha-catenin/vinculin	0	DIRECT
Complement components	0	DIRECT
Troponin I	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
B56-like	0	DIRECT
GDI-like N domain	0	DIRECT
MIR domain	0	DIRECT
Proteasome activator	0	DIRECT
Autophagin-like	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
PDI-like	0	DIRECT
Arginase-like amidino hydrolases	0	DIRECT
Mib/herc2 domain	0	DIRECT
ECR1 N-terminal domain-like	0	DIRECT
HIT (HINT, histidine triad) family of protein kinase-interacting proteins	0	DIRECT
NAP-like	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain	0	DIRECT
Ribosomal protein L3	0	DIRECT
MSP-like	0	DIRECT
Retinol binding protein-like	0	DIRECT
Myosin phosphatase inhibitor 17kDa protein, CPI-17	0	DIRECT
DJ-1/PfpI	0	DIRECT
P4 origin-binding domain-like	0	DIRECT
Carboxylesterase	0	DIRECT
alpha-ketoacid dehydrogenase kinase, N-terminal domain	0	DIRECT
Connexin43	0	DIRECT
Canonical RBD	0.00000109	DIRECT
Homeodomain	0.0001126	DIRECT
UBC-related	0.0004191	DIRECT
HLH, helix-loop-helix DNA-binding domain	0.0007271	DIRECT
Cyclin	0.007217	INHERITED FROM: migratory neural crest cell || postmigratory neural crest cell
Actin/HSP70	0.01488	INHERITED FROM: muscle || myocyte || jaw muscle || head mesoderm || head somite || cranial muscle || skeletal muscle
Forkhead DNA-binding domain	0.01497	INHERITED FROM: myocardium || anterior placodal area || involuted ventral mesoderm || vagal neural crest || presomitic mesoderm || mesenchyme || ciliated epidermal cell || head mesoderm || neural plate || mesoderm || pronephric nephrostome || neural crest || neural fold || epithelial cell || involuted dorsal mesoderm || sensorial layer of neurectoderm || pre-chordal neural plate || optic field || anterior neural fold || preplacodal ectoderm || tail tip || anterior neural ridge || tail fin || pre-chordal neural plate border || neuroectoderm
Proteasome subunits	0.02715	INHERITED FROM: muscle || skeletal muscle
Histone lysine methyltransferases	0.02715	INHERITED FROM: primary germ layer
Tandem AAA-ATPase domain	0.03514	INHERITED FROM: otic vesicle || ventral blood island
LIM domain	0.04036	INHERITED FROM: cranial placode || neuroectoderm
T-box	0.04583	INHERITED FROM: myocardium || involuted ventral mesoderm || regenerating tissue || mesenchyme || mesoderm || involuted dorsal mesoderm || primary heart field || blastema || neurogenic placode || notochord
Myb/SANT domain	0.04706	INHERITED FROM: ectoderm
Glutathione peroxidase-like	0.05006	INHERITED FROM: cranial neural crest || presumptive paraxial mesoderm || presomitic mesoderm || pronephric mesenchyme || pronephric tubule || proximal tubule || skeletal tissue || early proximal tubule || distal tubule || bone tissue || early distal tubule || paraxial mesoderm
Eukaryotic type KH-domain (KH-domain type I)	0.05778	INHERITED FROM: primary germ layer
HMG-box	0.06638	INHERITED FROM: cranial neural crest || endocardium || neural plate || blastocoel floor || neural crest || neural fold || midbrain-hindbrain boundary || neuroectoderm outer layer || endoderm || epibranchial placode || hyoid crest || retinal layer || pre-chordal neural plate || posterior branchial crest || optic field || anterior branchial crest || anterior neural fold || neural plate border || otic vesicle || neurogenic placode || neuroectoderm
Transforming growth factor (TGF)-beta	0.08199	INHERITED FROM: neural groove || regenerating tissue || foregut endoderm || involuting marginal zone mesenchymal layer || mesenchyme || head mesoderm || mesoderm || ventral mesoderm || head mesenchyme || endoderm || involuted dorsal mesoderm || gastrocoel roof plate || primary heart field || blastema || mouth primordium || vegetal endoderm || early distal tubule || secondary heart field || neurogenic placode || notochord
Tubulin, C-terminal domain	0.08934	INHERITED FROM: epidermal cell || epidermis || epithelial cell || archenteron || gastrocoel roof plate || non-neural ectoderm || facial nerve || vagus nerve || trigeminal nerve || glossopharyngeal nerve || epithelium
Tubulin, GTPase domain	0.08934	INHERITED FROM: epidermal cell || epidermis || epithelial cell || archenteron || gastrocoel roof plate || non-neural ectoderm || facial nerve || vagus nerve || trigeminal nerve || glossopharyngeal nerve || epithelium
Heat shock protein 70kD (HSP70), peptide-binding domain	0.09746	INHERITED FROM: skeletal muscle
Growth factor receptor domain	0.1184	INHERITED FROM: mesenchyme || fin || proximal tubule || mesoderm || hypochord || otic vesicle || notochord
Small Kunitz-type inhibitors & BPTI-like toxins	0.153	INHERITED FROM: adipose tissue
Group II chaperonin (CCT, TRIC), apical domain	0.1996	INHERITED FROM: muscle || anterior dorsal lateral plate region || skeletal muscle || lateral plate mesoderm
Translational machinery components	0.1996	INHERITED FROM: muscle || skeletal muscle
Thiolase-related	0.1996	INHERITED FROM: muscle || skeletal muscle
Group II chaperonin (CCT, TRIC), ATPase domain	0.2011	INHERITED FROM: muscle || anterior dorsal lateral plate region || skeletal muscle
Myosin rod fragments	0.2027	INHERITED FROM: musculature of face
Transducin (alpha subunit), insertion domain	0.2356	INHERITED FROM: olfactory epithelium || olfactory sensory neuron
POU-specific domain	0.2356	INHERITED FROM: retinal ganglion cell layer || pronephric mesenchyme || pronephric tubule || proximal tubule || neural plate || neural fold || distal tubule || chordal neural plate || pre-chordal neural plate || early distal tubule || late distal tubule || neurogenic placode || neuroectoderm
Erythroid transcription factor GATA-1	0.2503	INHERITED FROM: myocardium || anterior dorsal lateral plate region || hematopoietic stem cell || mesenchyme || mesoderm || endoderm || archenteron || archenteron floor || lateral plate mesoderm || ventral blood island
Ovomucoid domain III-like	0.259	INHERITED FROM: neural groove || neural plate || hypochord || notochord
Second domain of FERM	0.2601	INHERITED FROM: trigeminal nerve
Hemopexin-like domain	0.3026	INHERITED FROM: mesodermal cell || fibroblast || notochord
Cell cycle control phosphatase, catalytic domain	0.3147	INHERITED FROM: neural plate || chordal neural plate || neuroectoderm
Higher-molecular-weight phosphotyrosine protein phosphatases	0.3151	INHERITED FROM: retinal ganglion cell layer || retinal inner nuclear layer
Elongation factors	0.3295	INHERITED FROM: ventral blood island
Frizzled cysteine-rich domain	0.3612	INHERITED FROM: presumptive paraxial mesoderm || presomitic mesoderm || somite || mesenchyme || neural plate || mesoderm || neural fold || midbrain-hindbrain boundary || endoderm || involuted dorsal mesoderm || pre-chordal neural plate || ganglion || optic field || anterior neural fold || mouth primordium || tail tip || tail fin || stomodeal-hypophyseal primordium || lateral plate mesoderm || otic vesicle || neurogenic placode || neuroectoderm
Spectrin repeat	0.3612	INHERITED FROM: auditory hair cell || epithelial cell || sensory epithelial cell
Linker histone H1/H5	0.3923	INHERITED FROM: skeletal tissue || connective tissue || bone tissue
LDH N-terminal domain-like	0.3923	INHERITED FROM: skeletal tissue || connective tissue || bone tissue || skeletal muscle
Lactate & malate dehydrogenases, C-terminal domain	0.3923	INHERITED FROM: skeletal tissue || connective tissue || bone tissue || skeletal muscle
TSP type-3 repeat	0.3923	INHERITED FROM: epithelium
Thrombospondin C-terminal domain	0.3923	INHERITED FROM: epithelium
Matrix metalloproteases, catalytic domain	0.463	INHERITED FROM: mesodermal cell || fibroblast || notochord
AAT-like	0.4649	INHERITED FROM: presomitic mesoderm
I set domains	0.4706	INHERITED FROM: retinal ganglion cell layer || regenerating hindlimb || wound epidermis || retinal inner nuclear layer || pharyngeal mesenchyme
G proteins	0.502	INHERITED FROM: olfactory epithelium || olfactory sensory neuron
Sema domain	0.5275	INHERITED FROM: cranial neural crest || otic placode || neural plate || neural crest || midbrain-hindbrain boundary || involuted dorsal mesoderm || cranial placode || neuroectoderm
Link domain	0.5399	INHERITED FROM: presomitic mesoderm
Tropomyosin	0.5527	INHERITED FROM: myocardium || myotome || myocyte || dermomyotome
VWC domain	0.5619	INHERITED FROM: mesenchyme || mesoderm || endoderm || hypochord || notochord
Fibronectin type II module	0.626	INHERITED FROM: mesenchyme || epithelium
Globins	0.6312	INHERITED FROM: anterior dorsal lateral plate region || anterior ventral blood island || lateral plate mesoderm || ventral blood island
Intermediate filament protein, coiled coil region	0.632	INHERITED FROM: retinal ganglion cell layer || cranial nerve || spinal ganglion || vestibulocochlear nerve || epidermis || retinal inner plexiform layer || retinal ganglion cell || ganglion || retinal inner nuclear layer || nerve || retinal outer plexiform layer || optic nerve || epithelium
Kringle modules	0.6595	INHERITED FROM: neural groove
Multidrug efflux transporter AcrB transmembrane domain	0.7148	INHERITED FROM: epidermis
Arginine methyltransferase	0.7148	INHERITED FROM: cranial neural crest
Hypoxia-inducible factor Hif2a, C-terminal domain	0.8163	INHERITED FROM: pronephric tubule || otic vesicle || epaxial muscle
Integrin domains	0.83	INHERITED FROM: mesodermal cell || fibroblast
Ephrin receptor ligand binding domain	0.8463	INHERITED FROM: branchial crest
28-residue LRR	0.8739	INHERITED FROM: epaxial muscle
Proprotein convertase P-domain	0.9142	INHERITED FROM: notochord
Motor proteins	0.9637	INHERITED FROM: musculature of face
Protein kinases, catalytic subunit	0.9828	INHERITED FROM: regenerating hindlimb || head mesoderm || head mesenchyme
Tetramerization domain of potassium channels	1	INHERITED FROM: retinal inner plexiform layer || retinal outer plexiform layer || optic nerve
Classic zinc finger, C2H2	1	INHERITED FROM: chordal neural plate border || neural fold || splanchnic layer of lateral plate mesoderm || chordal neural plate || pre-chordal neural plate || anterior neural fold || anterior neural ridge || neural plate border || pre-chordal neural plate border
TSP-1 type 1 repeat	1	INHERITED FROM: hypochord
Calmodulin-like	1	INHERITED FROM: ciliated epidermal cell || epithelial cell
Plexin repeat	1	INHERITED FROM: cranial neural crest || otic placode || neural crest || cranial placode || neuroectoderm
Rhodopsin-like	1	INHERITED FROM: eye photoreceptor cell || granule cell layer of the olfactory bulb
Fibronectin type III	1	INHERITED FROM: retinal ganglion cell layer || retinal inner nuclear layer
Voltage-gated potassium channels	1	INHERITED FROM: retinal inner plexiform layer || optic nerve