•  SEARCH

  • Keyword search
  • Sequence search
• 
  

•  BROWSE

  •   Organisms
  • Taxonomy
  • Statistics
  •   SCOP
  • Hierarchy
  •   Ontologies
  • GO
  • EC
  • Phenotype
• 
  

•  TOOLS

  • Compare genomes
  • Phylogenetic trees
  • Web services
  • Downloads
• 
  

•  ABOUT

  • Description
  • Publications
  • Documentation
• 
  

•  HELP

  • User support
  • Contact us
  • Email list
  • Sitemap

Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

• Disease Ontology (DO) Ontology (DO)
  DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
  
• Human Phenotype (HP) Ontology (HP)
  HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
  
• Mouse Phenotype (MP) Ontology (MP)
  MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
  
• Worm Phenotype (WP) Ontology (WP)
  WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
  
• Yeast Phenotype (YP) Ontology (YP)
  Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
  
• Fly Phenotype (FP) Ontology (FP)
  FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
  
• Fly Anatomy (FA) Ontology (FA)
  FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
  
• Zebrafish Anatomy (ZA) Ontology (ZA)
  ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
  
• Xenopus Anatomy (XA) Ontology (XA)
  XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
  
• Arabidopsis Plant Ontology (AP) Ontology (AP)
  As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
  
• Enzyme Commission (EC) Ontology (EC)
  Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
  
• DrugBank ATC (DB) Ontology (DB)
  In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
  
• UniProtKB KeyWords (KW) Ontology (KW)
  Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
  
• UniProtKB UniPathway (UP) Ontology (UP)
  UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
  

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
  

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
  

Superfamily domains annotated to this XA term (SDXA level: Least Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
alpha-ketoacid dehydrogenase kinase, N-terminal domain	0	DIRECT
Nucleoplasmin-like core domain	0	DIRECT
SAP domain	0	DIRECT
Cap-Gly domain	0	DIRECT
Aconitase iron-sulfur domain	0	DIRECT
Sec63 N-terminal domain-like	0	DIRECT
Aminoacid dehydrogenase-like, N-terminal domain	0	DIRECT
C-terminal domain of adenylylcyclase associated protein	0	DIRECT
Translation proteins SH3-like domain	0	DIRECT
PAH2 domain	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
Sialidases	0	DIRECT
L-aspartase-like	0	DIRECT
Synuclein	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
KA1-like	0	DIRECT
GFP-like	0	DIRECT
Mitochondrial cytochrome c oxidase subunit VIIa	0	DIRECT
Acyl-CoA dehydrogenase C-terminal domain-like	0	DIRECT
E2F-DP heterodimerization region	0	DIRECT
Troponin coil-coiled subunits	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
4Fe-4S ferredoxins	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
Tim10-like	0	DIRECT
Subdomain of clathrin and coatomer appendage domain	0	DIRECT
BRK domain-like	0	DIRECT
Clathrin adaptor appendage domain	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Acyl-CoA dehydrogenase NM domain-like	0	DIRECT
Orange domain-like	0	DIRECT
Moesin tail domain	0	DIRECT
NTF2-like	0	DIRECT
Fibrinogen coiled-coil and central regions	0	DIRECT
post-AAA+ oligomerization domain-like	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
Mediator hinge subcomplex-like	0	DIRECT
Nucleoporin domain	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
NAP-like	0	DIRECT
LeuD/IlvD-like	0	DIRECT
Isocitrate/Isopropylmalate dehydrogenase-like	0	DIRECT
GINS helical bundle-like	0	DIRECT
Arginase/deacetylase	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Endosomal sorting complex assembly domain	0	DIRECT
Mib/herc2 domain-like	0	DIRECT
N-acetylmuramoyl-L-alanine amidase-like	0	DIRECT
CoA-dependent acyltransferases	0	DIRECT
PriA/YqbF domain	0	DIRECT
alpha-catenin/vinculin-like	0	DIRECT
DNA ligase/mRNA capping enzyme, catalytic domain	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
Class I glutamine amidotransferase-like	0	DIRECT
Ribulose-phoshate binding barrel	0	DIRECT
MIR domain	0	DIRECT
eIF4e-like	0	DIRECT
Zn-binding ribosomal proteins	0	DIRECT
Subunits of heterodimeric actin filament capping protein Capz	0	DIRECT
Cryptochrome/photolyase FAD-binding domain	0	DIRECT
Trefoil	0	DIRECT
BAG domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Alpha-macroglobulin receptor domain	0	DIRECT
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
FAS1 domain	0	DIRECT
Cryptochrome/photolyase, N-terminal domain	0	DIRECT
IP3 receptor type 1 binding core, domain 2	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Proteasome activator	0	DIRECT
PAP/OAS1 substrate-binding domain	0	DIRECT
PLP-binding barrel	0	DIRECT
Apolipoprotein A-I	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
FF domain	0	DIRECT
WGR domain-like	0	DIRECT
SPOC domain-like	0	DIRECT
TSP type-3 repeat	0	DIRECT
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	0	DIRECT
Connexin43	0	DIRECT
HRDC-like	0	DIRECT
SIS domain	0	DIRECT
Ferritin-like	0	DIRECT
Soluble quinoprotein glucose dehydrogenase	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
TK C-terminal domain-like	0	DIRECT
SMAD MH1 domain	0	DIRECT
Myosin phosphatase inhibitor 17kDa protein, CPI-17	0	DIRECT
BSD domain-like	0	DIRECT
G protein-binding domain	0	DIRECT
Uracil-DNA glycosylase-like	0	DIRECT
GYF domain	0	DIRECT
Hedgehog/DD-peptidase	0	DIRECT
ATP-dependent DNA ligase DNA-binding domain	0	DIRECT
TAFH domain-like	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Alanine racemase C-terminal domain-like	0	DIRECT
ADP-ribosylglycohydrolase	0	DIRECT
DLC	0	DIRECT
Nop domain	0	DIRECT
Notch domain	0	DIRECT
Ribosomal proteins L15p and L18e	0	DIRECT
LuxS/MPP-like metallohydrolase	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
Ribosomal proteins S24e, L23 and L15e	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
SRF-like	0	DIRECT
Bromodomain	0	DIRECT
Cytokine	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
FMT C-terminal domain-like	0	DIRECT
Ribosomal L27 protein-like	0	DIRECT
Delta-sleep-inducing peptide immunoreactive peptide	0	DIRECT
Di-copper centre-containing domain	0	DIRECT
14-3-3 protein	0	DIRECT
PEBP-like	0	DIRECT
RNA-binding domain, RBD	0.000004542	DIRECT
Homeodomain-like	0.00001111	DIRECT
"Winged helix" DNA-binding domain	0.00004771	DIRECT
Nucleic acid-binding proteins	0.0002581	DIRECT
HLH, helix-loop-helix DNA-binding domain	0.0003919	DIRECT
UBC-like	0.01607	INHERITED FROM: bone tissue
Thioredoxin-like	0.02091	INHERITED FROM: early proximal tubule || connective tissue || bone tissue || skeletal tissue
Cyclin-like	0.02537	INHERITED FROM: postmigratory neural crest cell
SET domain	0.03878	INHERITED FROM: primary germ layer
Actin depolymerizing proteins	0.05426	INHERITED FROM: connective tissue || bone tissue || skeletal tissue
HSP20-like chaperones	0.0589	INHERITED FROM: skeletal muscle
HMG-box	0.06139	INHERITED FROM: optic field || retinal layer || otic vesicle || endocardium || neural plate || neural plate border || pre-chordal neural plate || neural fold || neuroectoderm outer layer || chordal neural plate || midbrain-hindbrain boundary || anterior branchial crest || anterior neural fold || endoderm || blastocoel floor || cranial neural crest || posterior branchial crest || neuroectoderm || mandibular crest || neurogenic placode || neural crest || hyoid crest
ARID-like	0.1027	INHERITED FROM: pronephric tubule
Heat shock protein 70kD (HSP70), peptide-binding domain	0.1027	INHERITED FROM: skeletal muscle
Glucocorticoid receptor-like (DNA-binding domain)	0.1149	INHERITED FROM: zona limitans intrathalamica || cranial placode || preplacodal ectoderm || neuroectoderm || sensorial layer of neurectoderm || proximal tubule branch || archenteron floor || anterior placodal area
GroEL equatorial domain-like	0.1235	INHERITED FROM: skeletal muscle || anterior dorsal lateral plate region || endomesoderm || muscle
Actin-like ATPase domain	0.1279	INHERITED FROM: skeletal muscle || jaw muscle || myocyte || cranial muscle || head somite
p53-like transcription factors	0.1348	INHERITED FROM: neural plate || cranial placode || regenerating tissue || blastema || notochord || primary heart field || myocardium || cartilage tissue || neuroectoderm || mesenchyme || facial nerve || neurogenic placode || mesoderm || involuted ventral mesoderm
Tubulin C-terminal domain-like	0.1385	INHERITED FROM: epidermis || epithelial cell || gastrocoel roof plate || epithelium || trigeminal nerve || facial nerve || vagus nerve || epidermal cell || glossopharyngeal nerve || non-neural ectoderm
Thiolase-like	0.1655	INHERITED FROM: skeletal muscle
GroEL-intermediate domain like	0.1655	INHERITED FROM: skeletal muscle || anterior dorsal lateral plate region || endomesoderm || muscle
Transducin (alpha subunit), insertion domain	0.2407	INHERITED FROM: olfactory epithelium || olfactory sensory neuron
Spectrin repeat	0.2409	INHERITED FROM: epithelial cell || sensory epithelial cell || auditory hair cell
Tubulin nucleotide-binding domain-like	0.2599	INHERITED FROM: epidermis || epithelial cell || gastrocoel roof plate || epithelium || trigeminal nerve || facial nerve || vagus nerve || epidermal cell || glossopharyngeal nerve || non-neural ectoderm
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.2659	INHERITED FROM: skeletal muscle
Hemopexin-like domain	0.3017	INHERITED FROM: notochord || mesodermal cell || fibroblast
GroEL apical domain-like	0.3252	INHERITED FROM: skeletal muscle || anterior dorsal lateral plate region || muscle
Myosin rod fragments	0.35	INHERITED FROM: musculature of face
SMAD/FHA domain	0.355	INHERITED FROM: endocardium
Frizzled cysteine-rich domain	0.3607	INHERITED FROM: stomodeal-hypophyseal primordium || optic field || otic vesicle || tail tip || neural plate || pre-chordal neural plate || involuted dorsal mesoderm || neural fold || somite || presomitic mesoderm || midbrain-hindbrain boundary || anterior neural fold || tail fin || endoderm || neuroectoderm || mesenchyme || mouth primordium || mesoderm || lateral plate mesoderm || presumptive paraxial mesoderm
Clavaminate synthase-like	0.3776	INHERITED FROM: late proximal tubule || late distal tubule
Phosphoglycerate mutase-like	0.3823	INHERITED FROM: head mesenchyme || notochord || mesenchyme
Annexin	0.4029	INHERITED FROM: bone tissue
LDH C-terminal domain-like	0.4084	INHERITED FROM: connective tissue || bone tissue || skeletal tissue
Intermediate filament protein, coiled coil region	0.4135	INHERITED FROM: optic nerve || spinal ganglion || epidermis || epithelium || regenerating tissue || blastema || retinal inner nuclear layer || ganglion || retinal inner plexiform layer || cephalic nerve || retinal ganglion cell || nerve || retinal ganglion cell layer
Cystine-knot cytokines	0.4371	INHERITED FROM: ventral mesoderm || secondary heart field || involuting marginal zone mesenchymal layer || head mesenchyme || involuted dorsal mesoderm || regenerating tissue || blastema || notochord || vegetal endoderm || primary heart field || endoderm || neural groove || neuroectoderm || mesenchyme || mouth primordium || neurogenic placode || mesoderm || head mesoderm
PGBD-like	0.4628	INHERITED FROM: notochord || notochordal sheath
lambda repressor-like DNA-binding domains	0.5099	INHERITED FROM: early distal tubule || neural plate || cranial placode || pronephric mesenchyme || neural fold || chordal neural plate || proximal tubule || distal tubule || pronephric tubule || neuroectoderm || neurogenic placode || late distal tubule
Kringle-like	0.5697	INHERITED FROM: epithelium || neural groove
FnI-like domain	0.5777	INHERITED FROM: epithelial cell || hypochord || somite || notochord || endoderm
Globin-like	0.6385	INHERITED FROM: anterior dorsal lateral plate region || hematopoietic stem cell || ventral blood island || anterior ventral blood island
Growth factor receptor domain	0.655	INHERITED FROM: otic vesicle || tail tip || hypochord || pre-chordal neural plate border || notochord || mesenchyme || fin || anterior neural ridge
TIMP-like	0.6949	INHERITED FROM: stomodeal-hypophyseal primordium || optic field || pre-chordal neural plate || endoderm
Snake toxin-like	0.698	INHERITED FROM: ventral mesoderm || neural plate || pre-chordal neural plate || head mesenchyme || involuted dorsal mesoderm || chordal neural plate || neuroectoderm || mesenchyme || mesoderm || head mesoderm || lateral plate mesoderm
Kazal-type serine protease inhibitors	0.7218	INHERITED FROM: neural plate || hypochord || notochord || neural groove
Sema domain	0.7637	INHERITED FROM: cranial placode || involuted dorsal mesoderm || cranial neural crest || otic placode || neuroectoderm || neural crest
Protein kinase-like (PK-like)	0.773	INHERITED FROM: regenerating hindlimb || head mesoderm
Integrin domains	0.831	INHERITED FROM: mesodermal cell || fibroblast
EGF/Laminin	0.8315	INHERITED FROM: hypochord || notochord || neural groove
Tropomyosin	0.8591	INHERITED FROM: myocardium || myocyte || dermomyotome || myotome
PYP-like sensor domain (PAS domain)	0.9786	INHERITED FROM: epaxial muscle || somite || mesoderm
Voltage-gated potassium channels	1	INHERITED FROM: optic nerve || retinal inner plexiform layer || cephalic nerve || nerve || retinal ganglion cell layer
TSP-1 type 1 repeat	1	INHERITED FROM: hypochord
Fibronectin type III	1	INHERITED FROM: retinal inner nuclear layer || retinal ganglion cell layer
EF-hand	1	INHERITED FROM: myocyte
Ras GEF	1	INHERITED FROM: retinal inner plexiform layer || retinal outer plexiform layer
Metalloproteases ("zincins"), catalytic domain	1	INHERITED FROM: mesodermal cell || notochordal sheath || fibroblast
Family A G protein-coupled receptor-like	1	INHERITED FROM: granule cell layer of the olfactory bulb
beta-beta-alpha zinc fingers	1	INHERITED FROM: pre-chordal neural plate || chordal neural plate border || splanchnic layer of lateral plate mesoderm || neural fold || chordal neural plate || pre-chordal neural plate border || anterior neural ridge
Plexin repeat	1	INHERITED FROM: cranial placode || involuted dorsal mesoderm || cranial neural crest || otic placode || neuroectoderm || neural crest
Cadherin-like	1	INHERITED FROM: neural crest

Family domains annotated to this XA term (SDXA level: Least Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Translation initiation factor eIF4e	0	DIRECT
Hedgehog (development protein), N-terminal signaling domain	0	DIRECT
Ferritin	0	DIRECT
Trunk domain of Sec23/24	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain	0	DIRECT
IP3 receptor type 1 binding core, domain 2	0	DIRECT
Aminoacid dehydrogenase-like, C-terminal domain	0	DIRECT
MIR domain	0	DIRECT
Alpha-macroglobulin receptor domain	0	DIRECT
LeuD-like	0	DIRECT
MIF4G domain-like	0	DIRECT
Pumilio repeat	0	DIRECT
RNA-polymerase beta	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
Complement components	0	DIRECT
ets domain	0	DIRECT
Mib/herc2 domain	0	DIRECT
NTF2-like	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase Pyr module	0	DIRECT
Adenain-like	0	DIRECT
SMAD MH1 domain	0	DIRECT
ADP-ribosylglycohydrolase	0	DIRECT
Phosphatidylethanolamine binding protein	0	DIRECT
FAS1 domain	0	DIRECT
E2F dimerization segment	0	DIRECT
Class I aldolase	0	DIRECT
HD domain	0	DIRECT
Arginase-like amidino hydrolases	0	DIRECT
Cytochrome b5	0	DIRECT
Thrombospondin C-terminal domain	0	DIRECT
SAP domain	0	DIRECT
TAFH domain-like	0	DIRECT
Cell cycle transcription factor e2f-dp	0	DIRECT
HCDH C-domain-like	0	DIRECT
14-3-3 protein	0	DIRECT
HAT/Suf repeat	0	DIRECT
RUNT domain	0	DIRECT
NagB-like	0	DIRECT
DNA polymerase III clamp loader subunits, C-terminal domain	0	DIRECT
Proteasome activator	0	DIRECT
Prefoldin	0	DIRECT
gamma-adaptin C-terminal appendage domain-like	0	DIRECT
Guanido kinase catalytic domain	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
Cryptochrome/photolyase FAD-binding domain	0	DIRECT
Histone deacetylase, HDAC	0	DIRECT
TRASH domain	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
NIPSNAP	0	DIRECT
DNA ligase	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Paired domain	0	DIRECT
Pointed domain	0	DIRECT
Extracellular domain of cell surface receptors	0	DIRECT
Phenylalanine metabolism regulatory domain	0	DIRECT
MPP-like	0	DIRECT
Autophagin-like	0	DIRECT
Alpha-adaptin ear subdomain-like	0	DIRECT
IF2B-like	0	DIRECT
SRF-like	0	DIRECT
Notch domain	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
Aconitase iron-sulfur domain	0	DIRECT
SIAH, seven in absentia homolog	0	DIRECT
GABARAP-like	0	DIRECT
Trefoil	0	DIRECT
Sedlin (SEDL)	0	DIRECT
RNA-polymerase beta-prime	0	DIRECT
PDI-like	0	DIRECT
DNA ligase/mRNA capping enzyme postcatalytic domain	0	DIRECT
LON domain-like	0	DIRECT
ATP-dependent DNA ligase catalytic domain	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
MSP-like	0	DIRECT
DLC	0	DIRECT
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	0	DIRECT
Delta-sleep-inducing peptide immunoreactive peptide	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
Nucleoplasmin-like core domain	0	DIRECT
Alanine racemase-like, N-terminal domain	0	DIRECT
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
alpha-ketoacid dehydrogenase kinase, N-terminal domain	0	DIRECT
Class II glutamine amidotransferases	0	DIRECT
SMAD domain	0	DIRECT
N-type ATP pyrophosphatases	0	DIRECT
Dimeric isocitrate & isopropylmalate dehydrogenases	0	DIRECT
C-terminal domain of adenylylcyclase associated protein	0	DIRECT
Arrestin/Vps26-like	0	DIRECT
Choline/Carnitine O-acyltransferase	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
ZZ domain	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase PP module	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
WGR domain	0	DIRECT
BRK domain-like	0	DIRECT
Moesin tail domain	0	DIRECT
CAT-like	0	DIRECT
Apolipoprotein A-I	0	DIRECT
Noggin	0	DIRECT
Eukaryotic ODC-like	0	DIRECT
HIT (HINT, histidine triad) family of protein kinase-interacting proteins	0	DIRECT
Hairy Orange domain	0	DIRECT
Tim10/DDP	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
NAP-like	0	DIRECT
Cap-Gly domain	0	DIRECT
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
Bromodomain	0	DIRECT
Ribosomal proteins L15p and L18e	0	DIRECT
Sm motif of small nuclear ribonucleoproteins, SNRNP	0	DIRECT
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain	0	DIRECT
PAH2 domain	0	DIRECT
alpha-catenin/vinculin	0	DIRECT
Class I glutamine amidotransferases (GAT)	0	DIRECT
Heat-shock transcription factor	0	DIRECT
A20-like zinc finger	0	DIRECT
Domain G2 of nidogen-1	0	DIRECT
Carboxylesterase	0	DIRECT
Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	0	DIRECT
ECR1 N-terminal domain-like	0	DIRECT
alpha-ketoacid dehydrogenase kinase, C-terminal domain	0	DIRECT
BAG domain	0	DIRECT
Hsp90 middle domain	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
P4 origin-binding domain-like	0	DIRECT
Troponin I	0	DIRECT
acyl-CoA oxidase C-terminal domains	0	DIRECT
Retinol binding protein-like	0	DIRECT
Ribonuclease PH domain 1-like	0	DIRECT
Connexin43	0	DIRECT
UBX domain	0	DIRECT
L domain	0	DIRECT
Fibrinogen coiled-coil and central regions	0	DIRECT
Pseudouridine synthase I TruA	0	DIRECT
Mitochondrial cytochrome c oxidase subunit VIIa	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Ribosomal protein L3	0	DIRECT
MHCK/EF2 kinase	0	DIRECT
BSD domain	0	DIRECT
Malic enzyme N-domain	0	DIRECT
TRAPP components	0	DIRECT
Phosphoribosylpyrophosphate synthetase-like	0	DIRECT
Cryptochrome/photolyase, N-terminal domain	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
N-acetylmuramoyl-L-alanine amidase-like	0	DIRECT
Ran-binding domain	0	DIRECT
S-adenosylhomocystein hydrolase	0	DIRECT
DJ-1/PfpI	0	DIRECT
Noncollagenous (NC1) domain of collagen IV	0	DIRECT
Kinase associated domain 1, KA1	0	DIRECT
Nop domain	0	DIRECT
Fibroblast growth factors (FGF)	0	DIRECT
SH3BGR (SH3-binding, glutamic acid-rich protein-like)	0	DIRECT
Synuclein	0	DIRECT
Cytidylyltransferase	0	DIRECT
TSP type-3 repeat	0	DIRECT
Prokaryotic proteases	0	DIRECT
Troponin T	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
Polo-box duplicated region	0	DIRECT
NLI interacting factor-like phosphatase	0	DIRECT
Cystathionine synthase-like	0	DIRECT
Serine carboxypeptidase-like	0	DIRECT
Myosin phosphatase inhibitor 17kDa protein, CPI-17	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain	0	DIRECT
GDI-like N domain	0	DIRECT
Clathrin adaptor appendage, alpha and beta chain-specific domain	0	DIRECT
B56-like	0	DIRECT
acyl-CoA oxidase N-terminal domains	0	DIRECT
Cofilin-like	0	DIRECT
FF domain	0	DIRECT
Canonical RBD	0.000000305	DIRECT
Homeodomain	0.0002637	DIRECT
UBC-related	0.0004594	DIRECT
HLH, helix-loop-helix DNA-binding domain	0.0006991	DIRECT
Cyclin	0.009923	INHERITED FROM: postmigratory neural crest cell || migratory neural crest cell
Actin/HSP70	0.01593	INHERITED FROM: skeletal muscle || jaw muscle || trunk somite || myocyte || muscle || cranial muscle || head somite || head mesoderm
Forkhead DNA-binding domain	0.01624	INHERITED FROM: optic field || epithelial cell || tail tip || vagal neural crest || chordoneural hinge || neural plate || pre-chordal neural plate || ciliated epidermal cell || preplacodal ectoderm || involuted dorsal mesoderm || neural fold || pre-chordal neural plate border || presomitic mesoderm || anterior neural fold || tail fin || myocardium || neuroectoderm || mesenchyme || mesoderm || sensorial layer of neurectoderm || neural crest || head mesoderm || involuted ventral mesoderm || anterior placodal area || pronephric nephrostome || anterior neural ridge
Histone lysine methyltransferases	0.02852	INHERITED FROM: primary germ layer
Proteasome subunits	0.02852	INHERITED FROM: skeletal muscle || muscle
Tandem AAA-ATPase domain	0.03862	INHERITED FROM: otic vesicle || ventral blood island
LIM domain	0.04299	INHERITED FROM: cranial placode
T-box	0.04781	INHERITED FROM: involuted dorsal mesoderm || regenerating tissue || blastema || notochord || primary heart field || myocardium || mesenchyme || neurogenic placode || mesoderm || involuted ventral mesoderm
Glutathione peroxidase-like	0.0521	INHERITED FROM: early proximal tubule || early distal tubule || pronephric mesenchyme || paraxial mesoderm || proximal tubule || presomitic mesoderm || bone tissue || distal tubule || pronephric tubule || cranial neural crest || skeletal tissue || presumptive paraxial mesoderm
PHD domain	0.06342	INHERITED FROM: primary germ layer
HMG-box	0.07126	INHERITED FROM: optic field || retinal layer || otic vesicle || endocardium || neural plate || neural plate border || pre-chordal neural plate || neural fold || neuroectoderm outer layer || midbrain-hindbrain boundary || anterior branchial crest || anterior neural fold || endoderm || blastocoel floor || cranial neural crest || posterior branchial crest || neuroectoderm || mandibular crest || neurogenic placode || hyoid crest
Transforming growth factor (TGF)-beta	0.07301	INHERITED FROM: ventral mesoderm || secondary heart field || gastrocoel roof plate || early distal tubule || involuting marginal zone mesenchymal layer || head mesenchyme || involuted dorsal mesoderm || regenerating tissue || blastema || notochord || vegetal endoderm || primary heart field || endoderm || mesenchyme || mouth primordium || neurogenic placode || mesoderm || head mesoderm
ARID domain	0.101	INHERITED FROM: pronephric tubule
Heat shock protein 70kD (HSP70), peptide-binding domain	0.101	INHERITED FROM: skeletal muscle
Growth factor receptor domain	0.1265	INHERITED FROM: hypochord || notochord || mesenchyme || fin || mesoderm
Tubulin, GTPase domain	0.1445	INHERITED FROM: epidermis || epithelial cell || gastrocoel roof plate || epithelium || trigeminal nerve || facial nerve || vagus nerve || epidermal cell || glossopharyngeal nerve || non-neural ectoderm
Tubulin, C-terminal domain	0.1445	INHERITED FROM: epidermis || epithelial cell || gastrocoel roof plate || epithelium || trigeminal nerve || facial nerve || vagus nerve || epidermal cell || glossopharyngeal nerve || non-neural ectoderm
Small Kunitz-type inhibitors & BPTI-like toxins	0.1579	INHERITED FROM: adipose tissue
Thiolase-related	0.2059	INHERITED FROM: skeletal muscle || muscle
Group II chaperonin (CCT, TRIC), apical domain	0.2059	INHERITED FROM: skeletal muscle || anterior dorsal lateral plate region || muscle
Translational machinery components	0.2059	INHERITED FROM: skeletal muscle || muscle
Group II chaperonin (CCT, TRIC), ATPase domain	0.207	INHERITED FROM: skeletal muscle || muscle
Myosin rod fragments	0.2108	INHERITED FROM: musculature of face
Transducin (alpha subunit), insertion domain	0.2435	INHERITED FROM: olfactory epithelium || olfactory sensory neuron
POU-specific domain	0.2435	INHERITED FROM: early distal tubule || neural plate || pre-chordal neural plate || pronephric mesenchyme || neural fold || chordal neural plate || proximal tubule || distal tubule || pronephric tubule || neuroectoderm || neurogenic placode || late distal tubule || retinal ganglion cell layer
Erythroid transcription factor GATA-1	0.2575	INHERITED FROM: anterior dorsal lateral plate region || hematopoietic stem cell || endoderm || myocardium || archenteron || ventral blood island || mesoderm || archenteron floor || lateral plate mesoderm
Ovomucoid domain III-like	0.2673	INHERITED FROM: neural plate || hypochord || notochord || neural groove
Second domain of FERM	0.2718	INHERITED FROM: trigeminal nerve
Hemopexin-like domain	0.3138	INHERITED FROM: notochord || mesodermal cell || fibroblast
Parvalbumin	0.3221	INHERITED FROM: somite || cranial muscle
Cell cycle control phosphatase, catalytic domain	0.3221	INHERITED FROM: neural plate || chordal neural plate || neuroectoderm
Higher-molecular-weight phosphotyrosine protein phosphatases	0.3271	INHERITED FROM: retinal inner nuclear layer || retinal ganglion cell layer
I set domains	0.3395	INHERITED FROM: retinal inner nuclear layer || regenerating hindlimb || pharyngeal mesenchyme || wound epidermis || retinal ganglion cell layer
VWC domain	0.3436	INHERITED FROM: hypochord || notochord || endoderm || mesenchyme || mesoderm
Frizzled cysteine-rich domain	0.3733	INHERITED FROM: stomodeal-hypophyseal primordium || optic field || otic vesicle || tail tip || neural plate || pre-chordal neural plate || involuted dorsal mesoderm || neural fold || somite || presomitic mesoderm || midbrain-hindbrain boundary || anterior neural fold || tail fin || endoderm || neuroectoderm || mesenchyme || mouth primordium || mesoderm || lateral plate mesoderm || presumptive paraxial mesoderm
Spectrin repeat	0.3733	INHERITED FROM: epithelial cell || sensory epithelial cell || auditory hair cell
LDH N-terminal domain-like	0.399	INHERITED FROM: connective tissue || bone tissue || skeletal tissue
Linker histone H1/H5	0.399	INHERITED FROM: connective tissue || bone tissue || skeletal tissue
Lactate & malate dehydrogenases, C-terminal domain	0.399	INHERITED FROM: connective tissue || bone tissue || skeletal tissue
Matrix metalloproteases, catalytic domain	0.4134	INHERITED FROM: notochord || mesodermal cell || notochordal sheath || fibroblast
Intermediate filament protein, coiled coil region	0.4446	INHERITED FROM: optic nerve || spinal ganglion || epidermis || epithelium || regenerating tissue || blastema || retinal inner nuclear layer || ganglion || vestibulocochlear nerve || retinal inner plexiform layer || cephalic nerve || retinal ganglion cell || nerve || retinal ganglion cell layer
MMP N-terminal domain	0.4736	INHERITED FROM: notochord || notochordal sheath
Sema domain	0.5392	INHERITED FROM: neural plate || cranial placode || involuted dorsal mesoderm || midbrain-hindbrain boundary || cranial neural crest || otic placode || neuroectoderm || neural crest
G proteins	0.5643	INHERITED FROM: olfactory epithelium || olfactory sensory neuron
Fibronectin type II module	0.6306	INHERITED FROM: epithelium || mesenchyme
Globins	0.6382	INHERITED FROM: anterior dorsal lateral plate region || hematopoietic stem cell || ventral blood island || anterior ventral blood island
Kringle modules	0.6664	INHERITED FROM: neural groove
Tropomyosin	0.7011	INHERITED FROM: myocardium || myocyte || dermomyotome || myotome || multilaminar epithelium
Multidrug efflux transporter AcrB transmembrane domain	0.7201	INHERITED FROM: epidermis
Ephrin ectodomain	0.7201	INHERITED FROM: sensorial layer of neurectoderm
Arginine methyltransferase	0.7201	INHERITED FROM: cranial neural crest
Hypoxia-inducible factor Hif2a, C-terminal domain	0.8233	INHERITED FROM: epaxial muscle || otic vesicle || somite || pronephric tubule || mesoderm
Integrin domains	0.8385	INHERITED FROM: mesodermal cell || fibroblast
Ephrin receptor ligand binding domain	0.8521	INHERITED FROM: branchial crest
28-residue LRR	0.8798	INHERITED FROM: epaxial muscle
Proprotein convertase P-domain	0.9202	INHERITED FROM: notochord
Motor proteins	0.9556	INHERITED FROM: musculature of face
Protein kinases, catalytic subunit	0.9897	INHERITED FROM: regenerating hindlimb || head mesoderm
TSP-1 type 1 repeat	1	INHERITED FROM: hypochord
Calmodulin-like	1	INHERITED FROM: epithelial cell || ciliated epidermal cell
Fibronectin type III	1	INHERITED FROM: retinal ganglion cell layer
Rhodopsin-like	1	INHERITED FROM: granule cell layer of the olfactory bulb || eye photoreceptor cell
Voltage-gated potassium channels	1	INHERITED FROM: optic nerve || retinal inner plexiform layer
Classic zinc finger, C2H2	1	INHERITED FROM: neural plate border || pre-chordal neural plate || chordal neural plate border || splanchnic layer of lateral plate mesoderm || neural fold || chordal neural plate || pre-chordal neural plate border || anterior neural fold || anterior neural ridge
Plexin repeat	1	INHERITED FROM: cranial placode || cranial neural crest || otic placode || neuroectoderm || neural crest
Tetramerization domain of potassium channels	1	INHERITED FROM: optic nerve || retinal inner plexiform layer || retinal ganglion cell layer || retinal outer plexiform layer