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Xenopus ANatomical entity (XAN): tissue
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: XA Hierarchy (Xenopus anatomy and development from Xenbase frog anatomy ontology)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this XA term (SDXA level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
RBP11-like subunits of RNA polymerase | 0 | DIRECT |
Mitochondrial cytochrome c oxidase subunit VIIa | 0 | DIRECT |
Ferritin-like | 0 | DIRECT |
Nop domain | 0 | DIRECT |
Proteasome activator | 0 | DIRECT |
L-aspartase-like | 0 | DIRECT |
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
F1F0 ATP synthase subunit C | 0 | DIRECT |
4Fe-4S ferredoxins | 0 | DIRECT |
Fibrinogen coiled-coil and central regions | 0 | DIRECT |
Clathrin adaptor appendage domain | 0 | DIRECT |
DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
Helical domain of Sec23/24 | 0 | DIRECT |
Soluble quinoprotein glucose dehydrogenase | 0 | DIRECT |
HRDC-like | 0 | DIRECT |
beta-sandwich domain of Sec23/24 | 0 | DIRECT |
PAP/OAS1 substrate-binding domain | 0 | DIRECT |
WGR domain-like | 0 | DIRECT |
TAFH domain-like | 0 | DIRECT |
FF domain | 0 | DIRECT |
Mib/herc2 domain-like | 0 | DIRECT |
Guanido kinase N-terminal domain | 0 | DIRECT |
Sec63 N-terminal domain-like | 0 | DIRECT |
IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
Sialidases | 0 | DIRECT |
Acyl-CoA binding protein | 0 | DIRECT |
Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
Arginase/deacetylase | 0 | DIRECT |
BSD domain-like | 0 | DIRECT |
G protein-binding domain | 0 | DIRECT |
SMAD MH1 domain | 0 | DIRECT |
Surp module (SWAP domain) | 0 | DIRECT |
GINS helical bundle-like | 0 | DIRECT |
Orange domain-like | 0 | DIRECT |
HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
Acyl-CoA dehydrogenase NM domain-like | 0 | DIRECT |
alpha-catenin/vinculin-like | 0 | DIRECT |
Cryptochrome/photolyase, N-terminal domain | 0 | DIRECT |
TK C-terminal domain-like | 0 | DIRECT |
Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
post-AAA+ oligomerization domain-like | 0 | DIRECT |
PLP-binding barrel | 0 | DIRECT |
CoA-dependent acyltransferases | 0 | DIRECT |
Trefoil | 0 | DIRECT |
SAP domain | 0 | DIRECT |
beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | DIRECT |
GFP-like | 0 | DIRECT |
Zn-finger domain of Sec23/24 | 0 | DIRECT |
PEBP-like | 0 | DIRECT |
NTF2-like | 0 | DIRECT |
Troponin coil-coiled subunits | 0 | DIRECT |
DLC | 0 | DIRECT |
PAH2 domain | 0 | DIRECT |
FMT C-terminal domain-like | 0 | DIRECT |
Apolipoprotein A-I | 0 | DIRECT |
Zn-binding ribosomal proteins | 0 | DIRECT |
Ribosomal proteins L15p and L18e | 0 | DIRECT |
HSP90 C-terminal domain | 0 | DIRECT |
Synuclein | 0 | DIRECT |
Translation proteins SH3-like domain | 0 | DIRECT |
N-acetylmuramoyl-L-alanine amidase-like | 0 | DIRECT |
KA1-like | 0 | DIRECT |
Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
Di-copper centre-containing domain | 0 | DIRECT |
MIR domain | 0 | DIRECT |
Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
SRF-like | 0 | DIRECT |
LuxS/MPP-like metallohydrolase | 0 | DIRECT |
Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
Ribulose-phoshate binding barrel | 0 | DIRECT |
Uracil-DNA glycosylase-like | 0 | DIRECT |
PriA/YqbF domain | 0 | DIRECT |
BAG domain | 0 | DIRECT |
ADP-ribosylglycohydrolase | 0 | DIRECT |
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
Phosphoglucomutase, first 3 domains | 0 | DIRECT |
Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
Succinyl-CoA synthetase domains | 0 | DIRECT |
C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
Nucleoporin domain | 0 | DIRECT |
ATP-dependent DNA ligase DNA-binding domain | 0 | DIRECT |
Alpha-macroglobulin receptor domain | 0 | DIRECT |
Cap-Gly domain | 0 | DIRECT |
alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
Nucleoplasmin-like core domain | 0 | DIRECT |
Class I glutamine amidotransferase-like | 0 | DIRECT |
Ribonuclease PH domain 2-like | 0 | DIRECT |
Ribosomal protein L10-like | 0 | DIRECT |
LeuD/IlvD-like | 0 | DIRECT |
Tim10-like | 0 | DIRECT |
BRK domain-like | 0 | DIRECT |
NAP-like | 0 | DIRECT |
Bromodomain | 0 | DIRECT |
Aconitase iron-sulfur domain | 0 | DIRECT |
Cytokine | 0 | DIRECT |
SPOC domain-like | 0 | DIRECT |
Mediator hinge subcomplex-like | 0 | DIRECT |
DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
FAS1 domain | 0 | DIRECT |
Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
Connexin43 | 0 | DIRECT |
Delta-sleep-inducing peptide immunoreactive peptide | 0 | DIRECT |
Alanine racemase C-terminal domain-like | 0 | DIRECT |
14-3-3 protein | 0 | DIRECT |
Moesin tail domain | 0 | DIRECT |
Ribosomal proteins S24e, L23 and L15e | 0 | DIRECT |
Cysteine-rich DNA binding domain, (DM domain) | 0 | DIRECT |
E2F-DP heterodimerization region | 0 | DIRECT |
TSP type-3 repeat | 0 | DIRECT |
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
Subunits of heterodimeric actin filament capping protein Capz | 0 | DIRECT |
eIF4e-like | 0 | DIRECT |
Hedgehog/DD-peptidase | 0 | DIRECT |
Endosomal sorting complex assembly domain | 0 | DIRECT |
Ribosomal L27 protein-like | 0 | DIRECT |
C-terminal domain of adenylylcyclase associated protein | 0 | DIRECT |
SIS domain | 0 | DIRECT |
Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | DIRECT |
Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
Notch domain | 0 | DIRECT |
GYF domain | 0 | DIRECT |
RNA-binding domain, RBD | 0.000005086 | DIRECT |
Homeodomain-like | 0.00001255 | DIRECT |
"Winged helix" DNA-binding domain | 0.00005244 | DIRECT |
Nucleic acid-binding proteins | 0.0003523 | DIRECT |
HLH, helix-loop-helix DNA-binding domain | 0.0004154 | DIRECT |
Thioredoxin-like | 0.01188 | INHERITED FROM: bone tissue || skeletal tissue || connective tissue || early proximal tubule |
UBC-like | 0.01651 | INHERITED FROM: bone tissue |
Cyclin-like | 0.02601 | INHERITED FROM: postmigratory neural crest cell |
SET domain | 0.03947 | INHERITED FROM: primary germ layer |
Actin depolymerizing proteins | 0.055 | INHERITED FROM: bone tissue || skeletal tissue || connective tissue |
HSP20-like chaperones | 0.05981 | INHERITED FROM: skeletal muscle |
HMG-box | 0.06277 | INHERITED FROM: pre-chordal neural plate || optic field || retinal layer || blastocoel floor || neuroectoderm outer layer || neural crest || neural plate border || neural plate || otic vesicle || neural fold || hyoid crest || anterior neural fold || chordal neural plate || neurogenic placode || midbrain-hindbrain boundary || endoderm || endocardium || neuroectoderm || anterior branchial crest || mandibular crest || cranial neural crest || posterior branchial crest |
ARID-like | 0.1035 | INHERITED FROM: pronephric tubule |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0.1035 | INHERITED FROM: skeletal muscle |
Glucocorticoid receptor-like (DNA-binding domain) | 0.1183 | INHERITED FROM: proximal tubule branch || sensorial layer of neurectoderm || preplacodal ectoderm || cranial placode || anterior placodal area || neuroectoderm || zona limitans intrathalamica || archenteron floor || post-anal gut |
GroEL equatorial domain-like | 0.1242 | INHERITED FROM: muscle || endomesoderm || skeletal muscle || anterior dorsal lateral plate region |
Actin-like ATPase domain | 0.1298 | INHERITED FROM: head somite || skeletal muscle || cranial muscle || jaw muscle || myocyte |
p53-like transcription factors | 0.1369 | INHERITED FROM: involuted ventral mesoderm || mesenchyme || notochord || facial nerve || cranial placode || neural plate || primary heart field || myocardium || regenerating tissue || cartilage tissue || mesoderm || neurogenic placode || neuroectoderm || blastema |
Tubulin C-terminal domain-like | 0.1396 | INHERITED FROM: non-neural ectoderm || epidermis || vagus nerve || trigeminal nerve || epithelium || facial nerve || glossopharyngeal nerve || epithelial cell || gastrocoel roof plate || epidermal cell |
Thiolase-like | 0.1662 | INHERITED FROM: skeletal muscle |
GroEL-intermediate domain like | 0.1662 | INHERITED FROM: muscle || endomesoderm || skeletal muscle || anterior dorsal lateral plate region |
Second domain of FERM | 0.1987 | INHERITED FROM: nerve |
Transducin (alpha subunit), insertion domain | 0.2426 | INHERITED FROM: olfactory epithelium || olfactory sensory neuron |
Spectrin repeat | 0.2436 | INHERITED FROM: sensory epithelial cell || auditory hair cell || epithelial cell |
Tubulin nucleotide-binding domain-like | 0.2621 | INHERITED FROM: non-neural ectoderm || epidermis || vagus nerve || trigeminal nerve || epithelium || facial nerve || glossopharyngeal nerve || epithelial cell || gastrocoel roof plate || epidermal cell |
N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.2685 | INHERITED FROM: skeletal muscle |
GroEL apical domain-like | 0.3264 | INHERITED FROM: muscle || skeletal muscle || anterior dorsal lateral plate region |
Myosin rod fragments | 0.3527 | INHERITED FROM: musculature of face |
Hemopexin-like domain | 0.3527 | INHERITED FROM: notochord |
SMAD/FHA domain | 0.3594 | INHERITED FROM: endocardium |
Frizzled cysteine-rich domain | 0.363 | INHERITED FROM: pre-chordal neural plate || optic field || tail fin || mouth primordium || presumptive paraxial mesoderm || mesenchyme || lateral plate mesoderm || somite || neural plate || involuted dorsal mesoderm || otic vesicle || neural fold || mesoderm || anterior neural fold || tail tip || midbrain-hindbrain boundary || endoderm || presomitic mesoderm || stomodeal-hypophyseal primordium || neuroectoderm |
Clavaminate synthase-like | 0.3811 | INHERITED FROM: late proximal tubule || late distal tubule |
Phosphoglycerate mutase-like | 0.3845 | INHERITED FROM: head mesenchyme || mesenchyme || notochord |
Annexin | 0.4047 | INHERITED FROM: bone tissue |
LDH C-terminal domain-like | 0.4091 | INHERITED FROM: bone tissue || skeletal tissue || connective tissue |
Intermediate filament protein, coiled coil region | 0.4168 | INHERITED FROM: epidermis || epithelium || regenerating tissue || retinal ganglion cell || ganglion || spinal ganglion || cephalic nerve || retinal ganglion cell layer || retinal inner nuclear layer || blastema || optic nerve || nerve || retinal inner plexiform layer |
Cystine-knot cytokines | 0.442 | INHERITED FROM: neural groove || head mesenchyme || mouth primordium || mesenchyme || ventral mesoderm || notochord || involuting marginal zone mesenchymal layer || primary heart field || involuted dorsal mesoderm || regenerating tissue || mesoderm || head mesoderm || neurogenic placode || endoderm || secondary heart field || vegetal endoderm || blastema |
lambda repressor-like DNA-binding domains | 0.5128 | INHERITED FROM: pronephric tubule || cranial placode || neural plate || early distal tubule || neural fold || chordal neural plate || neurogenic placode || late distal tubule || distal tubule || neuroectoderm || pronephric mesenchyme || proximal tubule |
Kringle-like | 0.573 | INHERITED FROM: neural groove || epithelium |
FnI-like domain | 0.5813 | INHERITED FROM: notochord || somite || epithelial cell || endoderm || hypochord |
Globin-like | 0.6409 | INHERITED FROM: hematopoietic stem cell || anterior dorsal lateral plate region || ventral blood island || anterior ventral blood island |
Growth factor receptor domain | 0.6618 | INHERITED FROM: mesenchyme || notochord || otic vesicle || fin || tail tip || anterior neural ridge || hypochord || pre-chordal neural plate border |
TIMP-like | 0.6977 | INHERITED FROM: pre-chordal neural plate || optic field || endoderm || stomodeal-hypophyseal primordium |
Snake toxin-like | 0.7008 | INHERITED FROM: pre-chordal neural plate || head mesenchyme || mesenchyme || ventral mesoderm || lateral plate mesoderm || neural plate || involuted dorsal mesoderm || mesoderm || head mesoderm || chordal neural plate || neuroectoderm |
Kazal-type serine protease inhibitors | 0.7243 | INHERITED FROM: neural groove || notochord || neural plate || hypochord |
Tropomyosin | 0.7595 | INHERITED FROM: myotome || myocardium || dermomyotome || myocyte |
Sema domain | 0.767 | INHERITED FROM: otic placode || neural crest || cranial placode || involuted dorsal mesoderm || neuroectoderm || cranial neural crest |
Protein kinase-like (PK-like) | 0.7874 | INHERITED FROM: regenerating hindlimb || head mesoderm |
Integrin domains | 0.8331 | INHERITED FROM: fibroblast || mesodermal cell |
EGF/Laminin | 0.8377 | INHERITED FROM: neural groove || notochord || hypochord |
PYP-like sensor domain (PAS domain) | 0.9793 | INHERITED FROM: epaxial muscle || somite |
Family A G protein-coupled receptor-like | 1 | INHERITED FROM: granule cell layer of the olfactory bulb |
Galactose-binding domain-like | 1 | INHERITED FROM: optic nerve |
TSP-1 type 1 repeat | 1 | INHERITED FROM: hypochord |
Cadherin-like | 1 | INHERITED FROM: neural crest |
Plexin repeat | 1 | INHERITED FROM: otic placode || neural crest || cranial placode || involuted dorsal mesoderm || neuroectoderm || cranial neural crest |
Ras GEF | 1 | INHERITED FROM: retinal outer plexiform layer || retinal inner plexiform layer |
Voltage-gated potassium channels | 1 | INHERITED FROM: cephalic nerve || retinal ganglion cell layer || optic nerve || nerve || retinal inner plexiform layer |
beta-beta-alpha zinc fingers | 1 | INHERITED FROM: pre-chordal neural plate || splanchnic layer of lateral plate mesoderm || neural fold || chordal neural plate border || chordal neural plate || anterior neural ridge || pre-chordal neural plate border |
EF-hand | 1 | INHERITED FROM: myocyte |
Fibronectin type III | 1 | INHERITED FROM: retinal ganglion cell layer || retinal inner nuclear layer |
SCOP term | FDR (all) | Annotation (direct or inherited) |
RBP11-like subunits of RNA polymerase | 0 | Direct |
Mitochondrial cytochrome c oxidase subunit VIIa | 0 | Direct |
Ferritin-like | 0 | Direct |
Nop domain | 0 | Direct |
Proteasome activator | 0 | Direct |
L-aspartase-like | 0 | Direct |
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
F1F0 ATP synthase subunit C | 0 | Direct |
4Fe-4S ferredoxins | 0 | Direct |
Fibrinogen coiled-coil and central regions | 0 | Direct |
Clathrin adaptor appendage domain | 0 | Direct |
DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
Helical domain of Sec23/24 | 0 | Direct |
Soluble quinoprotein glucose dehydrogenase | 0 | Direct |
HRDC-like | 0 | Direct |
beta-sandwich domain of Sec23/24 | 0 | Direct |
PAP/OAS1 substrate-binding domain | 0 | Direct |
WGR domain-like | 0 | Direct |
TAFH domain-like | 0 | Direct |
FF domain | 0 | Direct |
Mib/herc2 domain-like | 0 | Direct |
Guanido kinase N-terminal domain | 0 | Direct |
Sec63 N-terminal domain-like | 0 | Direct |
IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
Sialidases | 0 | Direct |
Acyl-CoA binding protein | 0 | Direct |
Domain of poly(ADP-ribose) polymerase | 0 | Direct |
Arginase/deacetylase | 0 | Direct |
BSD domain-like | 0 | Direct |
G protein-binding domain | 0 | Direct |
SMAD MH1 domain | 0 | Direct |
Surp module (SWAP domain) | 0 | Direct |
GINS helical bundle-like | 0 | Direct |
Orange domain-like | 0 | Direct |
HSP40/DnaJ peptide-binding domain | 0 | Direct |
Acyl-CoA dehydrogenase NM domain-like | 0 | Direct |
alpha-catenin/vinculin-like | 0 | Direct |
Cryptochrome/photolyase, N-terminal domain | 0 | Direct |
TK C-terminal domain-like | 0 | Direct |
Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
post-AAA+ oligomerization domain-like | 0 | Direct |
PLP-binding barrel | 0 | Direct |
CoA-dependent acyltransferases | 0 | Direct |
Trefoil | 0 | Direct |
SAP domain | 0 | Direct |
beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | Direct |
GFP-like | 0 | Direct |
Zn-finger domain of Sec23/24 | 0 | Direct |
PEBP-like | 0 | Direct |
NTF2-like | 0 | Direct |
Troponin coil-coiled subunits | 0 | Direct |
DLC | 0 | Direct |
PAH2 domain | 0 | Direct |
FMT C-terminal domain-like | 0 | Direct |
Apolipoprotein A-I | 0 | Direct |
Zn-binding ribosomal proteins | 0 | Direct |
Ribosomal proteins L15p and L18e | 0 | Direct |
HSP90 C-terminal domain | 0 | Direct |
Synuclein | 0 | Direct |
Translation proteins SH3-like domain | 0 | Direct |
N-acetylmuramoyl-L-alanine amidase-like | 0 | Direct |
KA1-like | 0 | Direct |
Cation efflux protein cytoplasmic domain-like | 0 | Direct |
Di-copper centre-containing domain | 0 | Direct |
MIR domain | 0 | Direct |
Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
SRF-like | 0 | Direct |
LuxS/MPP-like metallohydrolase | 0 | Direct |
Phosphoglucomutase, C-terminal domain | 0 | Direct |
Ribulose-phoshate binding barrel | 0 | Direct |
Uracil-DNA glycosylase-like | 0 | Direct |
PriA/YqbF domain | 0 | Direct |
BAG domain | 0 | Direct |
ADP-ribosylglycohydrolase | 0 | Direct |
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
Phosphoglucomutase, first 3 domains | 0 | Direct |
Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
Succinyl-CoA synthetase domains | 0 | Direct |
C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
Nucleoporin domain | 0 | Direct |
ATP-dependent DNA ligase DNA-binding domain | 0 | Direct |
Alpha-macroglobulin receptor domain | 0 | Direct |
Cap-Gly domain | 0 | Direct |
alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
Nucleoplasmin-like core domain | 0 | Direct |
Class I glutamine amidotransferase-like | 0 | Direct |
Ribonuclease PH domain 2-like | 0 | Direct |
Ribosomal protein L10-like | 0 | Direct |
LeuD/IlvD-like | 0 | Direct |
Tim10-like | 0 | Direct |
BRK domain-like | 0 | Direct |
NAP-like | 0 | Direct |
Bromodomain | 0 | Direct |
Aconitase iron-sulfur domain | 0 | Direct |
Cytokine | 0 | Direct |
SPOC domain-like | 0 | Direct |
Mediator hinge subcomplex-like | 0 | Direct |
DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
FAS1 domain | 0 | Direct |
Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
Connexin43 | 0 | Direct |
Delta-sleep-inducing peptide immunoreactive peptide | 0 | Direct |
Alanine racemase C-terminal domain-like | 0 | Direct |
14-3-3 protein | 0 | Direct |
Moesin tail domain | 0 | Direct |
Ribosomal proteins S24e, L23 and L15e | 0 | Direct |
Cysteine-rich DNA binding domain, (DM domain) | 0 | Direct |
E2F-DP heterodimerization region | 0 | Direct |
TSP type-3 repeat | 0 | Direct |
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
Subunits of heterodimeric actin filament capping protein Capz | 0 | Direct |
eIF4e-like | 0 | Direct |
Hedgehog/DD-peptidase | 0 | Direct |
Endosomal sorting complex assembly domain | 0 | Direct |
Ribosomal L27 protein-like | 0 | Direct |
C-terminal domain of adenylylcyclase associated protein | 0 | Direct |
SIS domain | 0 | Direct |
Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | Direct |
Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
Notch domain | 0 | Direct |
GYF domain | 0 | Direct |
RNA-binding domain, RBD | 0.000005086 | Direct |
Homeodomain-like | 0.00001255 | Direct |
"Winged helix" DNA-binding domain | 0.00005244 | Direct |
Nucleic acid-binding proteins | 0.0003523 | Direct |
HLH, helix-loop-helix DNA-binding domain | 0.0004154 | Direct |
Thioredoxin-like | 0.01188 | Inherited |
UBC-like | 0.01651 | Inherited |
Cyclin-like | 0.02601 | Inherited |
SET domain | 0.03947 | Inherited |
Actin depolymerizing proteins | 0.055 | Inherited |
HSP20-like chaperones | 0.05981 | Inherited |
HMG-box | 0.06277 | Inherited |
ARID-like | 0.1035 | Inherited |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0.1035 | Inherited |
Glucocorticoid receptor-like (DNA-binding domain) | 0.1183 | Inherited |
GroEL equatorial domain-like | 0.1242 | Inherited |
Actin-like ATPase domain | 0.1298 | Inherited |
p53-like transcription factors | 0.1369 | Inherited |
Tubulin C-terminal domain-like | 0.1396 | Inherited |
Thiolase-like | 0.1662 | Inherited |
GroEL-intermediate domain like | 0.1662 | Inherited |
Second domain of FERM | 0.1987 | Inherited |
Transducin (alpha subunit), insertion domain | 0.2426 | Inherited |
Spectrin repeat | 0.2436 | Inherited |
Tubulin nucleotide-binding domain-like | 0.2621 | Inherited |
N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.2685 | Inherited |
GroEL apical domain-like | 0.3264 | Inherited |
Myosin rod fragments | 0.3527 | Inherited |
Hemopexin-like domain | 0.3527 | Inherited |
SMAD/FHA domain | 0.3594 | Inherited |
Frizzled cysteine-rich domain | 0.363 | Inherited |
Clavaminate synthase-like | 0.3811 | Inherited |
Phosphoglycerate mutase-like | 0.3845 | Inherited |
Annexin | 0.4047 | Inherited |
LDH C-terminal domain-like | 0.4091 | Inherited |
Intermediate filament protein, coiled coil region | 0.4168 | Inherited |
Cystine-knot cytokines | 0.442 | Inherited |
lambda repressor-like DNA-binding domains | 0.5128 | Inherited |
Kringle-like | 0.573 | Inherited |
FnI-like domain | 0.5813 | Inherited |
Globin-like | 0.6409 | Inherited |
Growth factor receptor domain | 0.6618 | Inherited |
TIMP-like | 0.6977 | Inherited |
Snake toxin-like | 0.7008 | Inherited |
Kazal-type serine protease inhibitors | 0.7243 | Inherited |
Tropomyosin | 0.7595 | Inherited |
Sema domain | 0.767 | Inherited |
Protein kinase-like (PK-like) | 0.7874 | Inherited |
Integrin domains | 0.8331 | Inherited |
EGF/Laminin | 0.8377 | Inherited |
PYP-like sensor domain (PAS domain) | 0.9793 | Inherited |
Family A G protein-coupled receptor-like | 1 | Inherited |
Galactose-binding domain-like | 1 | Inherited |
TSP-1 type 1 repeat | 1 | Inherited |
Cadherin-like | 1 | Inherited |
Plexin repeat | 1 | Inherited |
Ras GEF | 1 | Inherited |
Voltage-gated potassium channels | 1 | Inherited |
beta-beta-alpha zinc fingers | 1 | Inherited |
EF-hand | 1 | Inherited |
Fibronectin type III | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this XA term (SDXA level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
Aconitase iron-sulfur domain | 0 | DIRECT |
MIF4G domain-like | 0 | DIRECT |
C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
BSD domain | 0 | DIRECT |
SIAH, seven in absentia homolog | 0 | DIRECT |
FAS1 domain | 0 | DIRECT |
Arginase-like amidino hydrolases | 0 | DIRECT |
IF2B-like | 0 | DIRECT |
Alanine racemase-like, N-terminal domain | 0 | DIRECT |
S-adenosylhomocystein hydrolase | 0 | DIRECT |
E2F dimerization segment | 0 | DIRECT |
Troponin T | 0 | DIRECT |
Complement components | 0 | DIRECT |
SMAD domain | 0 | DIRECT |
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | DIRECT |
RNA-polymerase beta | 0 | DIRECT |
Adenain-like | 0 | DIRECT |
NTF2-like | 0 | DIRECT |
DNA ligase/mRNA capping enzyme postcatalytic domain | 0 | DIRECT |
Ribosomal proteins L15p and L18e | 0 | DIRECT |
GABARAP-like | 0 | DIRECT |
Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | DIRECT |
SH3BGR (SH3-binding, glutamic acid-rich protein-like) | 0 | DIRECT |
GDI-like N domain | 0 | DIRECT |
Phenylalanine metabolism regulatory domain | 0 | DIRECT |
LeuD-like | 0 | DIRECT |
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | DIRECT |
Ribosomal protein L3 | 0 | DIRECT |
Nop domain | 0 | DIRECT |
Hsp90 middle domain | 0 | DIRECT |
Translation initiation factor eIF4e | 0 | DIRECT |
Clathrin adaptor appendage, alpha and beta chain-specific domain | 0 | DIRECT |
Hedgehog (development protein), N-terminal signaling domain | 0 | DIRECT |
Pseudouridine synthase I TruA | 0 | DIRECT |
Moesin tail domain | 0 | DIRECT |
Guanido kinase N-terminal domain | 0 | DIRECT |
Ran-binding domain | 0 | DIRECT |
DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
Alpha-adaptin ear subdomain-like | 0 | DIRECT |
HAT/Suf repeat | 0 | DIRECT |
Noncollagenous (NC1) domain of collagen IV | 0 | DIRECT |
TAFH domain-like | 0 | DIRECT |
ets domain | 0 | DIRECT |
alpha-ketoacid dehydrogenase kinase, C-terminal domain | 0 | DIRECT |
CAT-like | 0 | DIRECT |
SRF-like | 0 | DIRECT |
PDI-like | 0 | DIRECT |
Connexin43 | 0 | DIRECT |
N-acetylmuramoyl-L-alanine amidase-like | 0 | DIRECT |
Cytochrome b5 | 0 | DIRECT |
Mitochondrial cytochrome c oxidase subunit VIIa | 0 | DIRECT |
Histone deacetylase, HDAC | 0 | DIRECT |
Cell cycle transcription factor e2f-dp | 0 | DIRECT |
Class II glutamine amidotransferases | 0 | DIRECT |
Class I glutamine amidotransferases (GAT) | 0 | DIRECT |
Phosphoglucomutase, first 3 domains | 0 | DIRECT |
Carboxylesterase | 0 | DIRECT |
Hairy Orange domain | 0 | DIRECT |
HIT (HINT, histidine triad) family of protein kinase-interacting proteins | 0 | DIRECT |
ZZ domain | 0 | DIRECT |
beta-sandwich domain of Sec23/24 | 0 | DIRECT |
acyl-CoA oxidase C-terminal domains | 0 | DIRECT |
SMAD MH1 domain | 0 | DIRECT |
alpha-catenin/vinculin | 0 | DIRECT |
Nucleoplasmin-like core domain | 0 | DIRECT |
Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
Mib/herc2 domain | 0 | DIRECT |
WGR domain | 0 | DIRECT |
Cysteine-rich DNA binding domain, (DM domain) | 0 | DIRECT |
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
Troponin I | 0 | DIRECT |
Proteasome activator | 0 | DIRECT |
NLI interacting factor-like phosphatase | 0 | DIRECT |
A20-like zinc finger | 0 | DIRECT |
Thrombospondin C-terminal domain | 0 | DIRECT |
Sm motif of small nuclear ribonucleoproteins, SNRNP | 0 | DIRECT |
Branched-chain alpha-keto acid dehydrogenase PP module | 0 | DIRECT |
Choline/Carnitine O-acyltransferase | 0 | DIRECT |
Succinyl-CoA synthetase domains | 0 | DIRECT |
Paired domain | 0 | DIRECT |
Malic enzyme N-domain | 0 | DIRECT |
DNA polymerase III clamp loader subunits, C-terminal domain | 0 | DIRECT |
L domain | 0 | DIRECT |
ADP-ribosylglycohydrolase | 0 | DIRECT |
RUNT domain | 0 | DIRECT |
C-terminal domain of adenylylcyclase associated protein | 0 | DIRECT |
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | DIRECT |
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | DIRECT |
Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | DIRECT |
HSP90 C-terminal domain | 0 | DIRECT |
Autophagin-like | 0 | DIRECT |
B56-like | 0 | DIRECT |
RNA-polymerase beta-prime | 0 | DIRECT |
Cystathionine synthase-like | 0 | DIRECT |
Fibroblast growth factors (FGF) | 0 | DIRECT |
MPP-like | 0 | DIRECT |
Bromodomain | 0 | DIRECT |
MSP-like | 0 | DIRECT |
P4 origin-binding domain-like | 0 | DIRECT |
NagB-like | 0 | DIRECT |
Kinase associated domain 1, KA1 | 0 | DIRECT |
NAP-like | 0 | DIRECT |
Cryptochrome/photolyase, N-terminal domain | 0 | DIRECT |
MIR domain | 0 | DIRECT |
BRK domain-like | 0 | DIRECT |
Phosphoribosylpyrophosphate synthetase-like | 0 | DIRECT |
SAP domain | 0 | DIRECT |
N-type ATP pyrophosphatases | 0 | DIRECT |
Zn-finger domain of Sec23/24 | 0 | DIRECT |
Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | DIRECT |
Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
Fibrinogen coiled-coil and central regions | 0 | DIRECT |
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
Retinol binding protein-like | 0 | DIRECT |
Serine carboxypeptidase-like | 0 | DIRECT |
DJ-1/PfpI | 0 | DIRECT |
ECR1 N-terminal domain-like | 0 | DIRECT |
Noggin | 0 | DIRECT |
Surp module (SWAP domain) | 0 | DIRECT |
LON domain-like | 0 | DIRECT |
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 0 | DIRECT |
Eukaryotic ODC-like | 0 | DIRECT |
HCDH C-domain-like | 0 | DIRECT |
acyl-CoA oxidase N-terminal domains | 0 | DIRECT |
Phosphatidylethanolamine binding protein | 0 | DIRECT |
Heat shock protein 90, HSP90, N-terminal domain | 0 | DIRECT |
Delta-sleep-inducing peptide immunoreactive peptide | 0 | DIRECT |
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | DIRECT |
F1F0 ATP synthase subunit C | 0 | DIRECT |
IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
Guanido kinase catalytic domain | 0 | DIRECT |
TSP type-3 repeat | 0 | DIRECT |
Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
Ribonuclease PH domain 2-like | 0 | DIRECT |
MHCK/EF2 kinase | 0 | DIRECT |
Cytidylyltransferase | 0 | DIRECT |
Pointed domain | 0 | DIRECT |
Arrestin/Vps26-like | 0 | DIRECT |
HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
Ferritin | 0 | DIRECT |
TRASH domain | 0 | DIRECT |
Ribonuclease PH domain 1-like | 0 | DIRECT |
Trunk domain of Sec23/24 | 0 | DIRECT |
BAG domain | 0 | DIRECT |
Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | DIRECT |
HD domain | 0 | DIRECT |
Prefoldin | 0 | DIRECT |
alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
Aminoacid dehydrogenase-like, C-terminal domain | 0 | DIRECT |
UBX domain | 0 | DIRECT |
gamma-adaptin C-terminal appendage domain-like | 0 | DIRECT |
Cap-Gly domain | 0 | DIRECT |
DLC | 0 | DIRECT |
Apolipoprotein A-I | 0 | DIRECT |
Trefoil | 0 | DIRECT |
Polo-box duplicated region | 0 | DIRECT |
DNA ligase | 0 | DIRECT |
Cofilin-like | 0 | DIRECT |
TRAPP components | 0 | DIRECT |
Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A | 0 | DIRECT |
Class I aldolase | 0 | DIRECT |
Sedlin (SEDL) | 0 | DIRECT |
NIPSNAP | 0 | DIRECT |
Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
Prokaryotic proteases | 0 | DIRECT |
Domain G2 of nidogen-1 | 0 | DIRECT |
Extracellular domain of cell surface receptors | 0 | DIRECT |
Heat-shock transcription factor | 0 | DIRECT |
Pumilio repeat | 0 | DIRECT |
Notch domain | 0 | DIRECT |
Synuclein | 0 | DIRECT |
Alpha-macroglobulin receptor domain | 0 | DIRECT |
Tim10/DDP | 0 | DIRECT |
Helical domain of Sec23/24 | 0 | DIRECT |
Acyl-CoA binding protein | 0 | DIRECT |
FF domain | 0 | DIRECT |
14-3-3 protein | 0 | DIRECT |
PAH2 domain | 0 | DIRECT |
C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
ATP-dependent DNA ligase catalytic domain | 0 | DIRECT |
Canonical RBD | 0.0000003397 | DIRECT |
Homeodomain | 0.0002904 | DIRECT |
UBC-related | 0.0004738 | DIRECT |
HLH, helix-loop-helix DNA-binding domain | 0.0007409 | DIRECT |
Cyclin | 0.01013 | INHERITED FROM: postmigratory neural crest cell || migratory neural crest cell |
Actin/HSP70 | 0.01622 | INHERITED FROM: muscle || head somite || skeletal muscle || trunk somite || head mesoderm || cranial muscle || jaw muscle || myocyte |
Forkhead DNA-binding domain | 0.01666 | INHERITED FROM: pre-chordal neural plate || optic field || involuted ventral mesoderm || tail fin || chordoneural hinge || vagal neural crest || mesenchyme || neural crest || sensorial layer of neurectoderm || preplacodal ectoderm || neural plate || myocardium || involuted dorsal mesoderm || neural fold || mesoderm || head mesoderm || epithelial cell || anterior neural fold || tail tip || anterior placodal area || presomitic mesoderm || ciliated epidermal cell || neuroectoderm || pronephric nephrostome || anterior neural ridge || pre-chordal neural plate border |
Histone lysine methyltransferases | 0.02889 | INHERITED FROM: primary germ layer |
Proteasome subunits | 0.02889 | INHERITED FROM: muscle || skeletal muscle |
Tandem AAA-ATPase domain | 0.03995 | INHERITED FROM: otic vesicle || ventral blood island |
LIM domain | 0.04388 | INHERITED FROM: cranial placode |
T-box | 0.04835 | INHERITED FROM: involuted ventral mesoderm || mesenchyme || notochord || primary heart field || myocardium || involuted dorsal mesoderm || regenerating tissue || mesoderm || neurogenic placode || blastema |
Glutathione peroxidase-like | 0.05267 | INHERITED FROM: pronephric tubule || presumptive paraxial mesoderm || bone tissue || early distal tubule || skeletal tissue || presomitic mesoderm || distal tubule || pronephric mesenchyme || proximal tubule || paraxial mesoderm || cranial neural crest || early proximal tubule |
PHD domain | 0.06489 | INHERITED FROM: primary germ layer |
HMG-box | 0.07266 | INHERITED FROM: pre-chordal neural plate || optic field || retinal layer || blastocoel floor || neuroectoderm outer layer || neural plate border || neural plate || otic vesicle || neural fold || hyoid crest || anterior neural fold || neurogenic placode || midbrain-hindbrain boundary || endoderm || endocardium || neuroectoderm || anterior branchial crest || mandibular crest || cranial neural crest || posterior branchial crest |
Transforming growth factor (TGF)-beta | 0.07427 | INHERITED FROM: head mesenchyme || foregut endoderm || mouth primordium || mesenchyme || ventral mesoderm || notochord || involuting marginal zone mesenchymal layer || primary heart field || early distal tubule || involuted dorsal mesoderm || regenerating tissue || mesoderm || head mesoderm || gastrocoel roof plate || neurogenic placode || endoderm || secondary heart field || vegetal endoderm || blastema |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0.1018 | INHERITED FROM: skeletal muscle |
ARID domain | 0.1018 | INHERITED FROM: pronephric tubule |
Growth factor receptor domain | 0.1287 | INHERITED FROM: mesenchyme || notochord || fin || mesoderm || hypochord |
Tubulin, GTPase domain | 0.1462 | INHERITED FROM: non-neural ectoderm || epidermis || vagus nerve || trigeminal nerve || epithelium || facial nerve || glossopharyngeal nerve || epithelial cell || gastrocoel roof plate || epidermal cell |
Tubulin, C-terminal domain | 0.1462 | INHERITED FROM: non-neural ectoderm || epidermis || vagus nerve || trigeminal nerve || epithelium || facial nerve || glossopharyngeal nerve || epithelial cell || gastrocoel roof plate || epidermal cell |
Small Kunitz-type inhibitors & BPTI-like toxins | 0.1588 | INHERITED FROM: adipose tissue |
Translational machinery components | 0.2066 | INHERITED FROM: muscle || skeletal muscle |
Thiolase-related | 0.2066 | INHERITED FROM: muscle || skeletal muscle |
Group II chaperonin (CCT, TRIC), apical domain | 0.2066 | INHERITED FROM: muscle || skeletal muscle || anterior dorsal lateral plate region |
Group II chaperonin (CCT, TRIC), ATPase domain | 0.2079 | INHERITED FROM: muscle || skeletal muscle |
Myosin rod fragments | 0.2125 | INHERITED FROM: musculature of face |
POU-specific domain | 0.2449 | INHERITED FROM: pre-chordal neural plate || pronephric tubule || neural plate || early distal tubule || neural fold || chordal neural plate || neurogenic placode || retinal ganglion cell layer || late distal tubule || distal tubule || neuroectoderm || pronephric mesenchyme || proximal tubule |
Transducin (alpha subunit), insertion domain | 0.2449 | INHERITED FROM: olfactory epithelium || olfactory sensory neuron |
Erythroid transcription factor GATA-1 | 0.2584 | INHERITED FROM: lateral plate mesoderm || hematopoietic stem cell || myocardium || archenteron || mesoderm || endoderm || anterior dorsal lateral plate region || archenteron floor || ventral blood island |
Ovomucoid domain III-like | 0.2687 | INHERITED FROM: neural groove || notochord || neural plate || hypochord |
Second domain of FERM | 0.2745 | INHERITED FROM: trigeminal nerve |
Parvalbumin | 0.3231 | INHERITED FROM: somite || cranial muscle |
Cell cycle control phosphatase, catalytic domain | 0.3231 | INHERITED FROM: neural plate || chordal neural plate || neuroectoderm |
Higher-molecular-weight phosphotyrosine protein phosphatases | 0.3295 | INHERITED FROM: retinal ganglion cell layer || retinal inner nuclear layer |
I set domains | 0.3445 | INHERITED FROM: regenerating hindlimb || pharyngeal mesenchyme || retinal ganglion cell layer || retinal inner nuclear layer || wound epidermis |
VWC domain | 0.345 | INHERITED FROM: mesenchyme || notochord || mesoderm || endoderm || hypochord |
Hemopexin-like domain | 0.3625 | INHERITED FROM: notochord |
Frizzled cysteine-rich domain | 0.376 | INHERITED FROM: pre-chordal neural plate || optic field || tail fin || mouth primordium || presumptive paraxial mesoderm || mesenchyme || lateral plate mesoderm || somite || neural plate || involuted dorsal mesoderm || otic vesicle || neural fold || mesoderm || anterior neural fold || tail tip || midbrain-hindbrain boundary || endoderm || presomitic mesoderm || stomodeal-hypophyseal primordium || neuroectoderm |
Spectrin repeat | 0.376 | INHERITED FROM: sensory epithelial cell || auditory hair cell || epithelial cell |
Lactate & malate dehydrogenases, C-terminal domain | 0.4003 | INHERITED FROM: bone tissue || skeletal tissue || connective tissue |
LDH N-terminal domain-like | 0.4003 | INHERITED FROM: bone tissue || skeletal tissue || connective tissue |
Linker histone H1/H5 | 0.4003 | INHERITED FROM: bone tissue || skeletal tissue || connective tissue |
Intermediate filament protein, coiled coil region | 0.449 | INHERITED FROM: epidermis || vestibulocochlear nerve || epithelium || regenerating tissue || retinal ganglion cell || ganglion || spinal ganglion || cephalic nerve || retinal ganglion cell layer || retinal inner nuclear layer || blastema || optic nerve || nerve || retinal inner plexiform layer |
Matrix metalloproteases, catalytic domain | 0.476 | INHERITED FROM: notochord |
Sema domain | 0.5427 | INHERITED FROM: otic placode || neural crest || cranial placode || neural plate || involuted dorsal mesoderm || midbrain-hindbrain boundary || neuroectoderm || cranial neural crest |
Tropomyosin | 0.5659 | INHERITED FROM: myotome || myocardium || multilaminar epithelium || dermomyotome || myocyte |
G proteins | 0.5935 | INHERITED FROM: olfactory epithelium || olfactory sensory neuron |
Fibronectin type II module | 0.6324 | INHERITED FROM: mesenchyme || epithelium |
Globins | 0.6405 | INHERITED FROM: hematopoietic stem cell || anterior dorsal lateral plate region || ventral blood island || anterior ventral blood island |
Kringle modules | 0.6699 | INHERITED FROM: neural groove |
Multidrug efflux transporter AcrB transmembrane domain | 0.7219 | INHERITED FROM: epidermis |
Arginine methyltransferase | 0.7219 | INHERITED FROM: cranial neural crest |
Hypoxia-inducible factor Hif2a, C-terminal domain | 0.8251 | INHERITED FROM: pronephric tubule || epaxial muscle || otic vesicle |
Integrin domains | 0.8405 | INHERITED FROM: fibroblast || mesodermal cell |
Ephrin receptor ligand binding domain | 0.8527 | INHERITED FROM: branchial crest |
28-residue LRR | 0.8816 | INHERITED FROM: epaxial muscle |
Proprotein convertase P-domain | 0.9209 | INHERITED FROM: notochord |
Motor proteins | 0.9587 | INHERITED FROM: musculature of face |
Protein kinases, catalytic subunit | 0.9969 | INHERITED FROM: regenerating hindlimb || head mesoderm |
TSP-1 type 1 repeat | 1 | INHERITED FROM: hypochord |
Calmodulin-like | 1 | INHERITED FROM: epithelial cell || ciliated epidermal cell |
Tetramerization domain of potassium channels | 1 | INHERITED FROM: retinal ganglion cell layer || retinal outer plexiform layer || optic nerve || retinal inner plexiform layer |
Plexin repeat | 1 | INHERITED FROM: otic placode || neural crest || cranial placode || neuroectoderm || cranial neural crest |
Rhodopsin-like | 1 | INHERITED FROM: granule cell layer of the olfactory bulb || eye photoreceptor cell |
Classic zinc finger, C2H2 | 1 | INHERITED FROM: pre-chordal neural plate || splanchnic layer of lateral plate mesoderm || neural plate border || neural fold || chordal neural plate border || anterior neural fold || chordal neural plate || anterior neural ridge || pre-chordal neural plate border |
Fibronectin type III | 1 | INHERITED FROM: retinal ganglion cell layer |
Voltage-gated potassium channels | 1 | INHERITED FROM: optic nerve || retinal inner plexiform layer |
SCOP term | FDR (all) | Annotation (direct or inherited) |
Aconitase iron-sulfur domain | 0 | Direct |
MIF4G domain-like | 0 | Direct |
C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
BSD domain | 0 | Direct |
SIAH, seven in absentia homolog | 0 | Direct |
FAS1 domain | 0 | Direct |
Arginase-like amidino hydrolases | 0 | Direct |
IF2B-like | 0 | Direct |
Alanine racemase-like, N-terminal domain | 0 | Direct |
S-adenosylhomocystein hydrolase | 0 | Direct |
E2F dimerization segment | 0 | Direct |
Troponin T | 0 | Direct |
Complement components | 0 | Direct |
SMAD domain | 0 | Direct |
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | Direct |
RNA-polymerase beta | 0 | Direct |
Adenain-like | 0 | Direct |
NTF2-like | 0 | Direct |
DNA ligase/mRNA capping enzyme postcatalytic domain | 0 | Direct |
Ribosomal proteins L15p and L18e | 0 | Direct |
GABARAP-like | 0 | Direct |
Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | Direct |
SH3BGR (SH3-binding, glutamic acid-rich protein-like) | 0 | Direct |
GDI-like N domain | 0 | Direct |
Phenylalanine metabolism regulatory domain | 0 | Direct |
LeuD-like | 0 | Direct |
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | Direct |
Ribosomal protein L3 | 0 | Direct |
Nop domain | 0 | Direct |
Hsp90 middle domain | 0 | Direct |
Translation initiation factor eIF4e | 0 | Direct |
Clathrin adaptor appendage, alpha and beta chain-specific domain | 0 | Direct |
Hedgehog (development protein), N-terminal signaling domain | 0 | Direct |
Pseudouridine synthase I TruA | 0 | Direct |
Moesin tail domain | 0 | Direct |
Guanido kinase N-terminal domain | 0 | Direct |
Ran-binding domain | 0 | Direct |
DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
Alpha-adaptin ear subdomain-like | 0 | Direct |
HAT/Suf repeat | 0 | Direct |
Noncollagenous (NC1) domain of collagen IV | 0 | Direct |
TAFH domain-like | 0 | Direct |
ets domain | 0 | Direct |
alpha-ketoacid dehydrogenase kinase, C-terminal domain | 0 | Direct |
CAT-like | 0 | Direct |
SRF-like | 0 | Direct |
PDI-like | 0 | Direct |
Connexin43 | 0 | Direct |
N-acetylmuramoyl-L-alanine amidase-like | 0 | Direct |
Cytochrome b5 | 0 | Direct |
Mitochondrial cytochrome c oxidase subunit VIIa | 0 | Direct |
Histone deacetylase, HDAC | 0 | Direct |
Cell cycle transcription factor e2f-dp | 0 | Direct |
Class II glutamine amidotransferases | 0 | Direct |
Class I glutamine amidotransferases (GAT) | 0 | Direct |
Phosphoglucomutase, first 3 domains | 0 | Direct |
Carboxylesterase | 0 | Direct |
Hairy Orange domain | 0 | Direct |
HIT (HINT, histidine triad) family of protein kinase-interacting proteins | 0 | Direct |
ZZ domain | 0 | Direct |
beta-sandwich domain of Sec23/24 | 0 | Direct |
acyl-CoA oxidase C-terminal domains | 0 | Direct |
SMAD MH1 domain | 0 | Direct |
alpha-catenin/vinculin | 0 | Direct |
Nucleoplasmin-like core domain | 0 | Direct |
Phosphoglucomutase, C-terminal domain | 0 | Direct |
Mib/herc2 domain | 0 | Direct |
WGR domain | 0 | Direct |
Cysteine-rich DNA binding domain, (DM domain) | 0 | Direct |
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
Troponin I | 0 | Direct |
Proteasome activator | 0 | Direct |
NLI interacting factor-like phosphatase | 0 | Direct |
A20-like zinc finger | 0 | Direct |
Thrombospondin C-terminal domain | 0 | Direct |
Sm motif of small nuclear ribonucleoproteins, SNRNP | 0 | Direct |
Branched-chain alpha-keto acid dehydrogenase PP module | 0 | Direct |
Choline/Carnitine O-acyltransferase | 0 | Direct |
Succinyl-CoA synthetase domains | 0 | Direct |
Paired domain | 0 | Direct |
Malic enzyme N-domain | 0 | Direct |
DNA polymerase III clamp loader subunits, C-terminal domain | 0 | Direct |
L domain | 0 | Direct |
ADP-ribosylglycohydrolase | 0 | Direct |
RUNT domain | 0 | Direct |
C-terminal domain of adenylylcyclase associated protein | 0 | Direct |
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | Direct |
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | Direct |
Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | Direct |
HSP90 C-terminal domain | 0 | Direct |
Autophagin-like | 0 | Direct |
B56-like | 0 | Direct |
RNA-polymerase beta-prime | 0 | Direct |
Cystathionine synthase-like | 0 | Direct |
Fibroblast growth factors (FGF) | 0 | Direct |
MPP-like | 0 | Direct |
Bromodomain | 0 | Direct |
MSP-like | 0 | Direct |
P4 origin-binding domain-like | 0 | Direct |
NagB-like | 0 | Direct |
Kinase associated domain 1, KA1 | 0 | Direct |
NAP-like | 0 | Direct |
Cryptochrome/photolyase, N-terminal domain | 0 | Direct |
MIR domain | 0 | Direct |
BRK domain-like | 0 | Direct |
Phosphoribosylpyrophosphate synthetase-like | 0 | Direct |
SAP domain | 0 | Direct |
N-type ATP pyrophosphatases | 0 | Direct |
Zn-finger domain of Sec23/24 | 0 | Direct |
Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | Direct |
Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
Fibrinogen coiled-coil and central regions | 0 | Direct |
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
Retinol binding protein-like | 0 | Direct |
Serine carboxypeptidase-like | 0 | Direct |
DJ-1/PfpI | 0 | Direct |
ECR1 N-terminal domain-like | 0 | Direct |
Noggin | 0 | Direct |
Surp module (SWAP domain) | 0 | Direct |
LON domain-like | 0 | Direct |
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 0 | Direct |
Eukaryotic ODC-like | 0 | Direct |
HCDH C-domain-like | 0 | Direct |
acyl-CoA oxidase N-terminal domains | 0 | Direct |
Phosphatidylethanolamine binding protein | 0 | Direct |
Heat shock protein 90, HSP90, N-terminal domain | 0 | Direct |
Delta-sleep-inducing peptide immunoreactive peptide | 0 | Direct |
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | Direct |
F1F0 ATP synthase subunit C | 0 | Direct |
IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
Guanido kinase catalytic domain | 0 | Direct |
TSP type-3 repeat | 0 | Direct |
Domain of poly(ADP-ribose) polymerase | 0 | Direct |
Ribonuclease PH domain 2-like | 0 | Direct |
MHCK/EF2 kinase | 0 | Direct |
Cytidylyltransferase | 0 | Direct |
Pointed domain | 0 | Direct |
Arrestin/Vps26-like | 0 | Direct |
HSP40/DnaJ peptide-binding domain | 0 | Direct |
Ferritin | 0 | Direct |
TRASH domain | 0 | Direct |
Ribonuclease PH domain 1-like | 0 | Direct |
Trunk domain of Sec23/24 | 0 | Direct |
BAG domain | 0 | Direct |
Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | Direct |
HD domain | 0 | Direct |
Prefoldin | 0 | Direct |
alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
Aminoacid dehydrogenase-like, C-terminal domain | 0 | Direct |
UBX domain | 0 | Direct |
gamma-adaptin C-terminal appendage domain-like | 0 | Direct |
Cap-Gly domain | 0 | Direct |
DLC | 0 | Direct |
Apolipoprotein A-I | 0 | Direct |
Trefoil | 0 | Direct |
Polo-box duplicated region | 0 | Direct |
DNA ligase | 0 | Direct |
Cofilin-like | 0 | Direct |
TRAPP components | 0 | Direct |
Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A | 0 | Direct |
Class I aldolase | 0 | Direct |
Sedlin (SEDL) | 0 | Direct |
NIPSNAP | 0 | Direct |
Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
Prokaryotic proteases | 0 | Direct |
Domain G2 of nidogen-1 | 0 | Direct |
Extracellular domain of cell surface receptors | 0 | Direct |
Heat-shock transcription factor | 0 | Direct |
Pumilio repeat | 0 | Direct |
Notch domain | 0 | Direct |
Synuclein | 0 | Direct |
Alpha-macroglobulin receptor domain | 0 | Direct |
Tim10/DDP | 0 | Direct |
Helical domain of Sec23/24 | 0 | Direct |
Acyl-CoA binding protein | 0 | Direct |
FF domain | 0 | Direct |
14-3-3 protein | 0 | Direct |
PAH2 domain | 0 | Direct |
C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
ATP-dependent DNA ligase catalytic domain | 0 | Direct |
Canonical RBD | 0.0000003397 | Direct |
Homeodomain | 0.0002904 | Direct |
UBC-related | 0.0004738 | Direct |
HLH, helix-loop-helix DNA-binding domain | 0.0007409 | Direct |
Cyclin | 0.01013 | Inherited |
Actin/HSP70 | 0.01622 | Inherited |
Forkhead DNA-binding domain | 0.01666 | Inherited |
Histone lysine methyltransferases | 0.02889 | Inherited |
Proteasome subunits | 0.02889 | Inherited |
Tandem AAA-ATPase domain | 0.03995 | Inherited |
LIM domain | 0.04388 | Inherited |
T-box | 0.04835 | Inherited |
Glutathione peroxidase-like | 0.05267 | Inherited |
PHD domain | 0.06489 | Inherited |
HMG-box | 0.07266 | Inherited |
Transforming growth factor (TGF)-beta | 0.07427 | Inherited |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0.1018 | Inherited |
ARID domain | 0.1018 | Inherited |
Growth factor receptor domain | 0.1287 | Inherited |
Tubulin, GTPase domain | 0.1462 | Inherited |
Tubulin, C-terminal domain | 0.1462 | Inherited |
Small Kunitz-type inhibitors & BPTI-like toxins | 0.1588 | Inherited |
Translational machinery components | 0.2066 | Inherited |
Thiolase-related | 0.2066 | Inherited |
Group II chaperonin (CCT, TRIC), apical domain | 0.2066 | Inherited |
Group II chaperonin (CCT, TRIC), ATPase domain | 0.2079 | Inherited |
Myosin rod fragments | 0.2125 | Inherited |
POU-specific domain | 0.2449 | Inherited |
Transducin (alpha subunit), insertion domain | 0.2449 | Inherited |
Erythroid transcription factor GATA-1 | 0.2584 | Inherited |
Ovomucoid domain III-like | 0.2687 | Inherited |
Second domain of FERM | 0.2745 | Inherited |
Parvalbumin | 0.3231 | Inherited |
Cell cycle control phosphatase, catalytic domain | 0.3231 | Inherited |
Higher-molecular-weight phosphotyrosine protein phosphatases | 0.3295 | Inherited |
I set domains | 0.3445 | Inherited |
VWC domain | 0.345 | Inherited |
Hemopexin-like domain | 0.3625 | Inherited |
Frizzled cysteine-rich domain | 0.376 | Inherited |
Spectrin repeat | 0.376 | Inherited |
Lactate & malate dehydrogenases, C-terminal domain | 0.4003 | Inherited |
LDH N-terminal domain-like | 0.4003 | Inherited |
Linker histone H1/H5 | 0.4003 | Inherited |
Intermediate filament protein, coiled coil region | 0.449 | Inherited |
Matrix metalloproteases, catalytic domain | 0.476 | Inherited |
Sema domain | 0.5427 | Inherited |
Tropomyosin | 0.5659 | Inherited |
G proteins | 0.5935 | Inherited |
Fibronectin type II module | 0.6324 | Inherited |
Globins | 0.6405 | Inherited |
Kringle modules | 0.6699 | Inherited |
Multidrug efflux transporter AcrB transmembrane domain | 0.7219 | Inherited |
Arginine methyltransferase | 0.7219 | Inherited |
Hypoxia-inducible factor Hif2a, C-terminal domain | 0.8251 | Inherited |
Integrin domains | 0.8405 | Inherited |
Ephrin receptor ligand binding domain | 0.8527 | Inherited |
28-residue LRR | 0.8816 | Inherited |
Proprotein convertase P-domain | 0.9209 | Inherited |
Motor proteins | 0.9587 | Inherited |
Protein kinases, catalytic subunit | 0.9969 | Inherited |
TSP-1 type 1 repeat | 1 | Inherited |
Calmodulin-like | 1 | Inherited |
Tetramerization domain of potassium channels | 1 | Inherited |
Plexin repeat | 1 | Inherited |
Rhodopsin-like | 1 | Inherited |
Classic zinc finger, C2H2 | 1 | Inherited |
Fibronectin type III | 1 | Inherited |
Voltage-gated potassium channels | 1 | Inherited |
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A presence/absence matrix is generated using protein domain
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this XA term (SPXA level: Least Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
Class I glutamine amidotransferase-like | 0 | DIRECT |
HRDC-like | 0 | DIRECT |
Nucleoporin domain | 0 | DIRECT |
Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | DIRECT |
14-3-3 protein | 0 | DIRECT |
BRK domain-like | 0 | DIRECT |
N-acetylmuramoyl-L-alanine amidase-like | 0 | DIRECT |
Aconitase iron-sulfur domain | 0 | DIRECT |
Nop domain | 0 | DIRECT |
Cryptochrome/photolyase, N-terminal domain | 0 | DIRECT |
SMAD MH1 domain | 0 | DIRECT |
Nucleoplasmin-like core domain | 0 | DIRECT |
PriA/YqbF domain | 0 | DIRECT |
Cytokine | 0 | DIRECT |
BAG domain | 0 | DIRECT |
Phosphoglucomutase, first 3 domains | 0 | DIRECT |
Acyl-CoA binding protein | 0 | DIRECT |
Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
Connexin43 | 0 | DIRECT |
Zn-finger domain of Sec23/24 | 0 | DIRECT |
Ribosomal L27 protein-like | 0 | DIRECT |
Ribosomal protein L10-like | 0 | DIRECT |
Moesin tail domain | 0 | DIRECT |
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
ADP-ribosylglycohydrolase | 0 | DIRECT |
SAP domain | 0 | DIRECT |
HSP90 C-terminal domain | 0 | DIRECT |
Uracil-DNA glycosylase-like | 0 | DIRECT |
Di-copper centre-containing domain | 0 | DIRECT |
Endosomal sorting complex assembly domain | 0 | DIRECT |
alpha-catenin/vinculin-like | 0 | DIRECT |
RBP11-like subunits of RNA polymerase | 0 | DIRECT |
Delta-sleep-inducing peptide immunoreactive peptide | 0 | DIRECT |
DLC | 0 | DIRECT |
Orange domain-like | 0 | DIRECT |
Acyl-CoA dehydrogenase NM domain-like | 0 | DIRECT |
DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
CoA-dependent acyltransferases | 0 | DIRECT |
Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
4Fe-4S ferredoxins | 0 | DIRECT |
ATP-dependent DNA ligase DNA-binding domain | 0 | DIRECT |
GYF domain | 0 | DIRECT |
Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
GFP-like | 0 | DIRECT |
Clathrin adaptor appendage domain | 0 | DIRECT |
eIF4e-like | 0 | DIRECT |
Helical domain of Sec23/24 | 0 | DIRECT |
Proteasome activator | 0 | DIRECT |
C-terminal domain of adenylylcyclase associated protein | 0 | DIRECT |
Mitochondrial cytochrome c oxidase subunit VIIa | 0 | DIRECT |
NAP-like | 0 | DIRECT |
SPOC domain-like | 0 | DIRECT |
Hedgehog/DD-peptidase | 0 | DIRECT |
PAH2 domain | 0 | DIRECT |
F1F0 ATP synthase subunit C | 0 | DIRECT |
E2F-DP heterodimerization region | 0 | DIRECT |
post-AAA+ oligomerization domain-like | 0 | DIRECT |
Arginase/deacetylase | 0 | DIRECT |
beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | DIRECT |
alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
BSD domain-like | 0 | DIRECT |
LeuD/IlvD-like | 0 | DIRECT |
Ribosomal proteins S24e, L23 and L15e | 0 | DIRECT |
Mediator hinge subcomplex-like | 0 | DIRECT |
Ferritin-like | 0 | DIRECT |
Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
Alanine racemase C-terminal domain-like | 0 | DIRECT |
TAFH domain-like | 0 | DIRECT |
Cysteine-rich DNA binding domain, (DM domain) | 0 | DIRECT |
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
FAS1 domain | 0 | DIRECT |
Notch domain | 0 | DIRECT |
GINS helical bundle-like | 0 | DIRECT |
SIS domain | 0 | DIRECT |
PAP/OAS1 substrate-binding domain | 0 | DIRECT |
Ribosomal proteins L15p and L18e | 0 | DIRECT |
IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
Tim10-like | 0 | DIRECT |
Soluble quinoprotein glucose dehydrogenase | 0 | DIRECT |
Subunits of heterodimeric actin filament capping protein Capz | 0 | DIRECT |
Trefoil | 0 | DIRECT |
Synuclein | 0 | DIRECT |
Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
Cap-Gly domain | 0 | DIRECT |
Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
PEBP-like | 0 | DIRECT |
Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
KA1-like | 0 | DIRECT |
L-aspartase-like | 0 | DIRECT |
beta-sandwich domain of Sec23/24 | 0 | DIRECT |
Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
G protein-binding domain | 0 | DIRECT |
TSP type-3 repeat | 0 | DIRECT |
TK C-terminal domain-like | 0 | DIRECT |
Translation proteins SH3-like domain | 0 | DIRECT |
MIR domain | 0 | DIRECT |
FF domain | 0 | DIRECT |
Sialidases | 0 | DIRECT |
Zn-binding ribosomal proteins | 0 | DIRECT |
Bromodomain | 0 | DIRECT |
Troponin coil-coiled subunits | 0 | DIRECT |
FMT C-terminal domain-like | 0 | DIRECT |
DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
Apolipoprotein A-I | 0 | DIRECT |
Mib/herc2 domain-like | 0 | DIRECT |
Ribulose-phoshate binding barrel | 0 | DIRECT |
WGR domain-like | 0 | DIRECT |
Surp module (SWAP domain) | 0 | DIRECT |
Ribonuclease PH domain 2-like | 0 | DIRECT |
LuxS/MPP-like metallohydrolase | 0 | DIRECT |
PLP-binding barrel | 0 | DIRECT |
Succinyl-CoA synthetase domains | 0 | DIRECT |
Alpha-macroglobulin receptor domain | 0 | DIRECT |
Guanido kinase N-terminal domain | 0 | DIRECT |
NTF2-like | 0 | DIRECT |
Sec63 N-terminal domain-like | 0 | DIRECT |
Fibrinogen coiled-coil and central regions | 0 | DIRECT |
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
SRF-like | 0 | DIRECT |
RNA-binding domain, RBD | 0.00000366 | DIRECT |
Homeodomain-like | 0.000009089 | DIRECT |
"Winged helix" DNA-binding domain | 0.00003854 | DIRECT |
Nucleic acid-binding proteins | 0.0002644 | DIRECT |
HLH, helix-loop-helix DNA-binding domain | 0.0003124 | DIRECT |
Thioredoxin-like | 0.009345 | INHERITED FROM: connective tissue || skeletal tissue || bone tissue || early proximal tubule |
UBC-like | 0.01306 | INHERITED FROM: skeletal tissue || bone tissue |
Cyclin-like | 0.02081 | INHERITED FROM: postmigratory neural crest cell |
SET domain | 0.03215 | INHERITED FROM: primary germ layer |
Actin depolymerizing proteins | 0.04526 | INHERITED FROM: connective tissue || skeletal tissue || bone tissue |
HSP20-like chaperones | 0.04935 | INHERITED FROM: skeletal muscle |
HMG-box | 0.05182 | INHERITED FROM: optic field || pre-chordal neural plate || branchial crest || anterior neural fold || neural fold || mandibular crest || cranial neural crest || neuroectoderm || posterior placodal area || neural plate || blastocoel floor || midbrain-hindbrain boundary || neural crest || otic vesicle || hyoid crest || neuroectoderm outer layer || chordal neural plate || endocardium || endoderm || neural plate border || anterior branchial crest || retinal layer || posterior branchial crest || neurogenic placode |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0.08778 | INHERITED FROM: skeletal muscle |
ARID-like | 0.08778 | INHERITED FROM: pronephric tubule |
Glucocorticoid receptor-like (DNA-binding domain) | 0.1014 | INHERITED FROM: sensorial layer of neurectoderm || post-anal gut || neuroectoderm || preplacodal ectoderm || proximal tubule branch || anterior placodal area || zona limitans intrathalamica || cranial placode || archenteron floor |
GroEL equatorial domain-like | 0.1069 | INHERITED FROM: skeletal muscle || endomesoderm || anterior dorsal lateral plate region || muscle |
Actin-like ATPase domain | 0.1121 | INHERITED FROM: jaw muscle || skeletal muscle || head somite || myocyte || cranial muscle |
Eukaryotic type KH-domain (KH-domain type I) | 0.1157 | INHERITED FROM: primary germ layer |
p53-like transcription factors | 0.1186 | INHERITED FROM: blastema || primary heart field || cartilage tissue || myocardium || neuroectoderm || mesenchyme || notochord || neural plate || facial nerve || mesoderm || cranial placode || involuted ventral mesoderm || regenerating tissue || neurogenic placode |
Tubulin C-terminal domain-like | 0.1211 | INHERITED FROM: non-neural ectoderm || glossopharyngeal nerve || epithelial cell || facial nerve || vagus nerve || trigeminal nerve || epidermis || epithelium || epidermal cell || gastrocoel roof plate |
BPTI-like | 0.1423 | INHERITED FROM: adipose tissue |
Thiolase-like | 0.1452 | INHERITED FROM: skeletal muscle |
GroEL-intermediate domain like | 0.1452 | INHERITED FROM: skeletal muscle || endomesoderm || anterior dorsal lateral plate region || muscle |
Second domain of FERM | 0.1754 | INHERITED FROM: nerve || cephalic nerve |
Transducin (alpha subunit), insertion domain | 0.2169 | INHERITED FROM: olfactory epithelium || olfactory sensory neuron |
Spectrin repeat | 0.2179 | INHERITED FROM: auditory hair cell || epithelial cell || sensory epithelial cell |
Translation proteins | 0.2179 | INHERITED FROM: skeletal muscle || ventral blood island |
Tubulin nucleotide-binding domain-like | 0.2349 | INHERITED FROM: non-neural ectoderm || glossopharyngeal nerve || epithelial cell || facial nerve || vagus nerve || trigeminal nerve || epidermis || epithelium || epidermal cell || gastrocoel roof plate |
N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.2413 | INHERITED FROM: skeletal muscle |
GroEL apical domain-like | 0.2969 | INHERITED FROM: skeletal muscle || anterior dorsal lateral plate region || muscle |
Myosin rod fragments | 0.3224 | INHERITED FROM: musculature of face |
Hemopexin-like domain | 0.3224 | INHERITED FROM: notochord |
SMAD/FHA domain | 0.3288 | INHERITED FROM: endocardium |
Frizzled cysteine-rich domain | 0.3326 | INHERITED FROM: optic field || pre-chordal neural plate || mouth primordium || anterior neural fold || neural fold || presomitic mesoderm || neuroectoderm || mesenchyme || neural plate || tail tip || midbrain-hindbrain boundary || mesoderm || otic vesicle || lateral plate mesoderm || ganglion || cranial ganglion || involuted dorsal mesoderm || endoderm || somite || presumptive paraxial mesoderm || stomodeal-hypophyseal primordium || tail fin |
Clavaminate synthase-like | 0.3502 | INHERITED FROM: late distal tubule || late proximal tubule || early proximal tubule |
Phosphoglycerate mutase-like | 0.3537 | INHERITED FROM: mesenchyme || notochord || head mesenchyme |
Annexin | 0.3739 | INHERITED FROM: connective tissue || skeletal tissue || bone tissue |
LDH C-terminal domain-like | 0.3778 | INHERITED FROM: connective tissue || skeletal tissue || bone tissue || skeletal muscle |
Pentein | 0.3778 | INHERITED FROM: skeletal muscle |
Intermediate filament protein, coiled coil region | 0.3849 | INHERITED FROM: retinal inner nuclear layer || blastema || retinal inner plexiform layer || retinal ganglion cell || vestibulocochlear nerve || nerve || cephalic nerve || epidermis || ganglion || retinal ganglion cell layer || epithelium || regenerating tissue || optic nerve || spinal ganglion |
Cystine-knot cytokines | 0.4087 | INHERITED FROM: blastema || mouth primordium || primary heart field || neuroectoderm || mesenchyme || notochord || mesoderm || neural groove || involuting marginal zone mesenchymal layer || involuted dorsal mesoderm || endoderm || vegetal endoderm || head mesoderm || secondary heart field || ventral mesoderm || regenerating tissue || head mesenchyme || neurogenic placode |
lambda repressor-like DNA-binding domains | 0.4786 | INHERITED FROM: neural fold || neuroectoderm || late distal tubule || early distal tubule || neural plate || proximal tubule || chordal neural plate || cranial placode || pronephric mesenchyme || distal tubule || pronephric tubule || neurogenic placode |
Kringle-like | 0.5371 | INHERITED FROM: neural groove || epithelium |
FnI-like domain | 0.5456 | INHERITED FROM: hypochord || epithelial cell || notochord || endoderm || somite |
P-loop containing nucleoside triphosphate hydrolases | 0.5959 | INHERITED FROM: olfactory sensory neuron |
Globin-like | 0.6057 | INHERITED FROM: anterior ventral blood island || lateral plate mesoderm || hematopoietic stem cell || ventral blood island || anterior dorsal lateral plate region |
Growth factor receptor domain | 0.6268 | INHERITED FROM: hypochord || pre-chordal neural plate border || mesenchyme || fin || notochord || tail tip || otic vesicle || anterior neural ridge |
TIMP-like | 0.6631 | INHERITED FROM: optic field || pre-chordal neural plate || endoderm || stomodeal-hypophyseal primordium |
Snake toxin-like | 0.6663 | INHERITED FROM: pre-chordal neural plate || neuroectoderm || mesenchyme || neural plate || mesoderm || lateral plate mesoderm || chordal neural plate || dorsal lateral plate mesoderm || involuted dorsal mesoderm || head mesoderm || ventral mesoderm || head mesenchyme |
Kazal-type serine protease inhibitors | 0.6899 | INHERITED FROM: hypochord || notochord || neural plate || neural groove |
Tropomyosin | 0.7254 | INHERITED FROM: multilaminar epithelium || dermomyotome || myocardium || myocyte || myotome |
Sema domain | 0.7334 | INHERITED FROM: otic placode || cranial neural crest || neuroectoderm || neural crest || cranial placode || involuted dorsal mesoderm |
Protein kinase-like (PK-like) | 0.7546 | INHERITED FROM: head mesoderm || regenerating hindlimb |
Integrin domains | 0.8026 | INHERITED FROM: mesodermal cell || fibroblast |
EGF/Laminin | 0.8077 | INHERITED FROM: hypochord || notochord || neural groove || dorsal fin |
PYP-like sensor domain (PAS domain) | 0.9537 | INHERITED FROM: epaxial muscle || somite |
Plexin repeat | 0.9984 | INHERITED FROM: otic placode || cranial neural crest || neuroectoderm || neural crest || cranial placode || involuted dorsal mesoderm |
Family A G protein-coupled receptor-like | 1 | INHERITED FROM: granule cell layer of the olfactory bulb |
Ras GEF | 1 | INHERITED FROM: retinal inner plexiform layer || retinal outer plexiform layer |
Fibronectin type III | 1 | INHERITED FROM: retinal inner nuclear layer || retinal ganglion cell layer |
TSP-1 type 1 repeat | 1 | INHERITED FROM: hypochord |
beta-beta-alpha zinc fingers | 1 | INHERITED FROM: pre-chordal neural plate || neural fold || pre-chordal neural plate border || chordal neural plate border || chordal neural plate || splanchnic layer of lateral plate mesoderm || anterior neural ridge |
Voltage-gated potassium channels | 1 | INHERITED FROM: retinal inner plexiform layer || nerve || cephalic nerve || retinal ganglion cell layer || optic nerve |
EF-hand | 1 | INHERITED FROM: myocyte |
Cadherin-like | 1 | INHERITED FROM: neural crest |
Immunoglobulin | 1 | INHERITED FROM: retinal inner nuclear layer |
Galactose-binding domain-like | 1 | INHERITED FROM: optic nerve |
Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
Class I glutamine amidotransferase-like | 0 | Direct |
HRDC-like | 0 | Direct |
Nucleoporin domain | 0 | Direct |
Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | Direct |
14-3-3 protein | 0 | Direct |
BRK domain-like | 0 | Direct |
N-acetylmuramoyl-L-alanine amidase-like | 0 | Direct |
Aconitase iron-sulfur domain | 0 | Direct |
Nop domain | 0 | Direct |
Cryptochrome/photolyase, N-terminal domain | 0 | Direct |
SMAD MH1 domain | 0 | Direct |
Nucleoplasmin-like core domain | 0 | Direct |
PriA/YqbF domain | 0 | Direct |
Cytokine | 0 | Direct |
BAG domain | 0 | Direct |
Phosphoglucomutase, first 3 domains | 0 | Direct |
Acyl-CoA binding protein | 0 | Direct |
Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
Connexin43 | 0 | Direct |
Zn-finger domain of Sec23/24 | 0 | Direct |
Ribosomal L27 protein-like | 0 | Direct |
Ribosomal protein L10-like | 0 | Direct |
Moesin tail domain | 0 | Direct |
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
ADP-ribosylglycohydrolase | 0 | Direct |
SAP domain | 0 | Direct |
HSP90 C-terminal domain | 0 | Direct |
Uracil-DNA glycosylase-like | 0 | Direct |
Di-copper centre-containing domain | 0 | Direct |
Endosomal sorting complex assembly domain | 0 | Direct |
alpha-catenin/vinculin-like | 0 | Direct |
RBP11-like subunits of RNA polymerase | 0 | Direct |
Delta-sleep-inducing peptide immunoreactive peptide | 0 | Direct |
DLC | 0 | Direct |
Orange domain-like | 0 | Direct |
Acyl-CoA dehydrogenase NM domain-like | 0 | Direct |
DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
CoA-dependent acyltransferases | 0 | Direct |
Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
4Fe-4S ferredoxins | 0 | Direct |
ATP-dependent DNA ligase DNA-binding domain | 0 | Direct |
GYF domain | 0 | Direct |
Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
GFP-like | 0 | Direct |
Clathrin adaptor appendage domain | 0 | Direct |
eIF4e-like | 0 | Direct |
Helical domain of Sec23/24 | 0 | Direct |
Proteasome activator | 0 | Direct |
C-terminal domain of adenylylcyclase associated protein | 0 | Direct |
Mitochondrial cytochrome c oxidase subunit VIIa | 0 | Direct |
NAP-like | 0 | Direct |
SPOC domain-like | 0 | Direct |
Hedgehog/DD-peptidase | 0 | Direct |
PAH2 domain | 0 | Direct |
F1F0 ATP synthase subunit C | 0 | Direct |
E2F-DP heterodimerization region | 0 | Direct |
post-AAA+ oligomerization domain-like | 0 | Direct |
Arginase/deacetylase | 0 | Direct |
beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | Direct |
alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
BSD domain-like | 0 | Direct |
LeuD/IlvD-like | 0 | Direct |
Ribosomal proteins S24e, L23 and L15e | 0 | Direct |
Mediator hinge subcomplex-like | 0 | Direct |
Ferritin-like | 0 | Direct |
Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
Alanine racemase C-terminal domain-like | 0 | Direct |
TAFH domain-like | 0 | Direct |
Cysteine-rich DNA binding domain, (DM domain) | 0 | Direct |
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
FAS1 domain | 0 | Direct |
Notch domain | 0 | Direct |
GINS helical bundle-like | 0 | Direct |
SIS domain | 0 | Direct |
PAP/OAS1 substrate-binding domain | 0 | Direct |
Ribosomal proteins L15p and L18e | 0 | Direct |
IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
Tim10-like | 0 | Direct |
Soluble quinoprotein glucose dehydrogenase | 0 | Direct |
Subunits of heterodimeric actin filament capping protein Capz | 0 | Direct |
Trefoil | 0 | Direct |
Synuclein | 0 | Direct |
Phosphoglucomutase, C-terminal domain | 0 | Direct |
Cap-Gly domain | 0 | Direct |
Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
PEBP-like | 0 | Direct |
Domain of poly(ADP-ribose) polymerase | 0 | Direct |
KA1-like | 0 | Direct |
L-aspartase-like | 0 | Direct |
beta-sandwich domain of Sec23/24 | 0 | Direct |
Cation efflux protein cytoplasmic domain-like | 0 | Direct |
HSP40/DnaJ peptide-binding domain | 0 | Direct |
G protein-binding domain | 0 | Direct |
TSP type-3 repeat | 0 | Direct |
TK C-terminal domain-like | 0 | Direct |
Translation proteins SH3-like domain | 0 | Direct |
MIR domain | 0 | Direct |
FF domain | 0 | Direct |
Sialidases | 0 | Direct |
Zn-binding ribosomal proteins | 0 | Direct |
Bromodomain | 0 | Direct |
Troponin coil-coiled subunits | 0 | Direct |
FMT C-terminal domain-like | 0 | Direct |
DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
Apolipoprotein A-I | 0 | Direct |
Mib/herc2 domain-like | 0 | Direct |
Ribulose-phoshate binding barrel | 0 | Direct |
WGR domain-like | 0 | Direct |
Surp module (SWAP domain) | 0 | Direct |
Ribonuclease PH domain 2-like | 0 | Direct |
LuxS/MPP-like metallohydrolase | 0 | Direct |
PLP-binding barrel | 0 | Direct |
Succinyl-CoA synthetase domains | 0 | Direct |
Alpha-macroglobulin receptor domain | 0 | Direct |
Guanido kinase N-terminal domain | 0 | Direct |
NTF2-like | 0 | Direct |
Sec63 N-terminal domain-like | 0 | Direct |
Fibrinogen coiled-coil and central regions | 0 | Direct |
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
SRF-like | 0 | Direct |
RNA-binding domain, RBD | 0.00000366 | Direct |
Homeodomain-like | 0.000009089 | Direct |
"Winged helix" DNA-binding domain | 0.00003854 | Direct |
Nucleic acid-binding proteins | 0.0002644 | Direct |
HLH, helix-loop-helix DNA-binding domain | 0.0003124 | Direct |
Thioredoxin-like | 0.009345 | Inherited |
UBC-like | 0.01306 | Inherited |
Cyclin-like | 0.02081 | Inherited |
SET domain | 0.03215 | Inherited |
Actin depolymerizing proteins | 0.04526 | Inherited |
HSP20-like chaperones | 0.04935 | Inherited |
HMG-box | 0.05182 | Inherited |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0.08778 | Inherited |
ARID-like | 0.08778 | Inherited |
Glucocorticoid receptor-like (DNA-binding domain) | 0.1014 | Inherited |
GroEL equatorial domain-like | 0.1069 | Inherited |
Actin-like ATPase domain | 0.1121 | Inherited |
Eukaryotic type KH-domain (KH-domain type I) | 0.1157 | Inherited |
p53-like transcription factors | 0.1186 | Inherited |
Tubulin C-terminal domain-like | 0.1211 | Inherited |
BPTI-like | 0.1423 | Inherited |
Thiolase-like | 0.1452 | Inherited |
GroEL-intermediate domain like | 0.1452 | Inherited |
Second domain of FERM | 0.1754 | Inherited |
Transducin (alpha subunit), insertion domain | 0.2169 | Inherited |
Spectrin repeat | 0.2179 | Inherited |
Translation proteins | 0.2179 | Inherited |
Tubulin nucleotide-binding domain-like | 0.2349 | Inherited |
N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.2413 | Inherited |
GroEL apical domain-like | 0.2969 | Inherited |
Myosin rod fragments | 0.3224 | Inherited |
Hemopexin-like domain | 0.3224 | Inherited |
SMAD/FHA domain | 0.3288 | Inherited |
Frizzled cysteine-rich domain | 0.3326 | Inherited |
Clavaminate synthase-like | 0.3502 | Inherited |
Phosphoglycerate mutase-like | 0.3537 | Inherited |
Annexin | 0.3739 | Inherited |
LDH C-terminal domain-like | 0.3778 | Inherited |
Pentein | 0.3778 | Inherited |
Intermediate filament protein, coiled coil region | 0.3849 | Inherited |
Cystine-knot cytokines | 0.4087 | Inherited |
lambda repressor-like DNA-binding domains | 0.4786 | Inherited |
Kringle-like | 0.5371 | Inherited |
FnI-like domain | 0.5456 | Inherited |
P-loop containing nucleoside triphosphate hydrolases | 0.5959 | Inherited |
Globin-like | 0.6057 | Inherited |
Growth factor receptor domain | 0.6268 | Inherited |
TIMP-like | 0.6631 | Inherited |
Snake toxin-like | 0.6663 | Inherited |
Kazal-type serine protease inhibitors | 0.6899 | Inherited |
Tropomyosin | 0.7254 | Inherited |
Sema domain | 0.7334 | Inherited |
Protein kinase-like (PK-like) | 0.7546 | Inherited |
Integrin domains | 0.8026 | Inherited |
EGF/Laminin | 0.8077 | Inherited |
PYP-like sensor domain (PAS domain) | 0.9537 | Inherited |
Plexin repeat | 0.9984 | Inherited |
Family A G protein-coupled receptor-like | 1 | Inherited |
Ras GEF | 1 | Inherited |
Fibronectin type III | 1 | Inherited |
TSP-1 type 1 repeat | 1 | Inherited |
beta-beta-alpha zinc fingers | 1 | Inherited |
Voltage-gated potassium channels | 1 | Inherited |
EF-hand | 1 | Inherited |
Cadherin-like | 1 | Inherited |
Immunoglobulin | 1 | Inherited |
Galactose-binding domain-like | 1 | Inherited |
(show details)
Supra-domains annotated to this XA term (SPXA level: Least Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57938,49493 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
81995,81811 81995 - beta-sandwich domain of Sec23/24 81811 - Helical domain of Sec23/24 | 0 | DIRECT |
57630,57196 57630 - GLA-domain 57196 - EGF/Laminin | 0 | DIRECT |
57196,50494 57196 - EGF/Laminin 50494 - Trypsin-like serine proteases | 0 | DIRECT |
52058,57184 52058 - L domain-like 57184 - Growth factor receptor domain | 0 | DIRECT |
103647,103647 103647 - TSP type-3 repeat 103647 - TSP type-3 repeat | 0 | DIRECT |
57184,49265 57184 - Growth factor receptor domain 49265 - Fibronectin type III | 0 | DIRECT |
54452,48726 54452 - MHC antigen-recognition domain 48726 - Immunoglobulin | 0 | DIRECT |
47661,58038 47661 - t-snare proteins 58038 - SNARE fusion complex | 0 | DIRECT |
47587,56399 47587 - Domain of poly(ADP-ribose) polymerase 56399 - ADP-ribosylation | 0 | DIRECT |
69012,55874 69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
46966,47473 46966 - Spectrin repeat 47473 - EF-hand | 0 | DIRECT |
82895,57424 82895 - TSP-1 type 1 repeat 57424 - LDL receptor-like module | 0 | DIRECT |
56059,52210 56059 - Glutathione synthetase ATP-binding domain-like 52210 - Succinyl-CoA synthetase domains | 0 | DIRECT |
53738,55957 53738 - Phosphoglucomutase, first 3 domains 55957 - Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
100895,47473 100895 - Kazal-type serine protease inhibitors 47473 - EF-hand | 0 | DIRECT |
53223,51735 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
54534,54534 54534 - FKBP-like 54534 - FKBP-like | 0 | DIRECT |
56645,47203 56645 - Acyl-CoA dehydrogenase NM domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
110324,50249 110324 - Ribosomal L27 protein-like 50249 - Nucleic acid-binding proteins | 0 | DIRECT |
81296,48239 81296 - E set domains 48239 - Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
49854,57196 49854 - Spermadhesin, CUB domain 57196 - EGF/Laminin | 0 | DIRECT |
48726,56436 48726 - Immunoglobulin 56436 - C-type lectin-like | 0 | DIRECT |
47459,158457 47459 - HLH, helix-loop-helix DNA-binding domain 158457 - Orange domain-like | 0 | DIRECT |
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like | 0 | DIRECT |
55486,48371 55486 - Metalloproteases ("zincins"), catalytic domain 48371 - ARM repeat | 0 | DIRECT |
55550,55550 55550 - SH2 domain 55550 - SH2 domain | 0 | DIRECT |
54511,57184 54511 - GFP-like 57184 - Growth factor receptor domain | 0 | DIRECT |
47095,47095 47095 - HMG-box 47095 - HMG-box | 0 | DIRECT |
142921,47587 142921 - WGR domain-like 47587 - Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
81811,82754 81811 - Helical domain of Sec23/24 82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
53732,52016 53732 - Aconitase iron-sulfur domain 52016 - LeuD/IlvD-like | 0 | DIRECT |
52518,52922 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52922 - TK C-terminal domain-like | 0 | DIRECT |
52425,48173 52425 - Cryptochrome/photolyase, N-terminal domain 48173 - Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
46565,57938 46565 - Chaperone J-domain 57938 - DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
117018,56091 117018 - ATP-dependent DNA ligase DNA-binding domain 56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
57196,56436 57196 - EGF/Laminin 56436 - C-type lectin-like | 0 | DIRECT |
52777,52777 52777 - CoA-dependent acyltransferases 52777 - CoA-dependent acyltransferases | 0 | DIRECT |
52518,52518 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
82109,82109 82109 - MIR domain 82109 - MIR domain | 0 | DIRECT |
49899,52540 49899 - Concanavalin A-like lectins/glucanases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
90209,90209 90209 - Ran binding protein zinc finger-like 90209 - Ran binding protein zinc finger-like | 0 | DIRECT |
52540,53254 52540 - P-loop containing nucleoside triphosphate hydrolases 53254 - Phosphoglycerate mutase-like | 0 | DIRECT |
52540,48019 52540 - P-loop containing nucleoside triphosphate hydrolases 48019 - post-AAA+ oligomerization domain-like | 0 | DIRECT |
81301,81631 81301 - Nucleotidyltransferase 81631 - PAP/OAS1 substrate-binding domain | 0 | DIRECT |
57196,90193 57196 - EGF/Laminin 90193 - Notch domain | 0 | DIRECT |
54211,55060 54211 - Ribosomal protein S5 domain 2-like 55060 - GHMP Kinase, C-terminal domain | 0 | DIRECT |
49348,55711 49348 - Clathrin adaptor appendage domain 55711 - Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
90257,90257 90257 - Myosin rod fragments 90257 - Myosin rod fragments | 0 | DIRECT |
56436,57535 56436 - C-type lectin-like 57535 - Complement control module/SCR domain | 0 | DIRECT |
103647,49899 103647 - TSP type-3 repeat 49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
53738,53738 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains | 0 | DIRECT |
46785,144074 46785 - "Winged helix" DNA-binding domain 144074 - E2F-DP heterodimerization region | 0 | DIRECT |
47473,103506 47473 - EF-hand 103506 - Mitochondrial carrier | 0 | DIRECT |
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
51230,47005 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
51419,50621 51419 - PLP-binding barrel 50621 - Alanine racemase C-terminal domain-like | 0 | DIRECT |
51045,56204 51045 - WW domain 56204 - Hect, E3 ligase catalytic domain | 0 | DIRECT |
54236,57889 54236 - Ubiquitin-like 57889 - Cysteine-rich domain | 0 | DIRECT |
47005,52777 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 52777 - CoA-dependent acyltransferases | 0 | DIRECT |
47203,47203 47203 - Acyl-CoA dehydrogenase C-terminal domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
57196,100895 57196 - EGF/Laminin 100895 - Kazal-type serine protease inhibitors | 0 | DIRECT |
55021,56534 55021 - ACT-like 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
57756,57756 57756 - Retrovirus zinc finger-like domains 57756 - Retrovirus zinc finger-like domains | 0 | DIRECT |
54160,57850 54160 - Chromo domain-like 57850 - RING/U-box | 0 | DIRECT |
47370,47370 47370 - Bromodomain 47370 - Bromodomain | 0 | DIRECT |
57903,47370 57903 - FYVE/PHD zinc finger 47370 - Bromodomain | 0 | DIRECT |
49493,49493 49493 - HSP40/DnaJ peptide-binding domain 49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
54403,54403 54403 - Cystatin/monellin 54403 - Cystatin/monellin | 0 | DIRECT |
82153,82153 82153 - FAS1 domain 82153 - FAS1 domain | 0 | DIRECT |
52540,46785 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
82615,82615 82615 - Polo-box domain 82615 - Polo-box domain | 0 | DIRECT |
47220,47220 47220 - alpha-catenin/vinculin-like 47220 - alpha-catenin/vinculin-like | 0 | DIRECT |
50044,50156 50044 - SH3-domain 50156 - PDZ domain-like | 0 | DIRECT |
88723,47807 88723 - PIN domain-like 47807 - 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
53300,81995 53300 - vWA-like 81995 - beta-sandwich domain of Sec23/24 | 0 | DIRECT |
48034,55931 48034 - Guanido kinase N-terminal domain 55931 - Glutamine synthetase/guanido kinase | 0 | DIRECT |
82919,53300 82919 - Zn-finger domain of Sec23/24 53300 - vWA-like | 0 | DIRECT |
161111,160240 161111 - Cation efflux protein transmembrane domain-like 160240 - Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
82109,100909 82109 - MIR domain 100909 - IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
57184,57610 57184 - Growth factor receptor domain 57610 - Thyroglobulin type-1 domain | 0 | DIRECT |
54211,55666 54211 - Ribosomal protein S5 domain 2-like 55666 - Ribonuclease PH domain 2-like | 0 | DIRECT |
81698,81698 81698 - FF domain 81698 - FF domain | 0 | DIRECT |
63411,63411 63411 - LuxS/MPP-like metallohydrolase 63411 - LuxS/MPP-like metallohydrolase | 0 | DIRECT |
57184,100895 57184 - Growth factor receptor domain 100895 - Kazal-type serine protease inhibitors | 0 | DIRECT |
52058,49265 52058 - L domain-like 49265 - Fibronectin type III | 0 | DIRECT |
56091,50249 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins | 0 | DIRECT |
57184,52058 57184 - Growth factor receptor domain 52058 - L domain-like | 0 | DIRECT |
48371,46785 48371 - ARM repeat 46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
54631,54631 54631 - CBS-domain pair 54631 - CBS-domain pair | 0 | DIRECT |
54928,54928 54928 - RNA-binding domain, RBD 54928 - RNA-binding domain, RBD | 0.00001658 | DIRECT |
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.003939 | INHERITED FROM: sensorial layer of neurectoderm || post-anal gut || neuroectoderm || preplacodal ectoderm || nerve || cephalic nerve || anterior placodal area || zona limitans intrathalamica || otic vesicle || cranial placode || ventral blood island || endoderm || trigeminal ganglion || archenteron floor || archenteron || anterior dorsal lateral plate region |
54791,54791 54791 - Eukaryotic type KH-domain (KH-domain type I) 54791 - Eukaryotic type KH-domain (KH-domain type I) | 0.02296 | INHERITED FROM: primary germ layer |
47954,47954 47954 - Cyclin-like 47954 - Cyclin-like | 0.0744 | INHERITED FROM: migratory neural crest cell || postmigratory neural crest cell |
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.08778 | INHERITED FROM: skeletal muscle |
52490,55307 52490 - Tubulin nucleotide-binding domain-like 55307 - Tubulin C-terminal domain-like | 0.1211 | INHERITED FROM: non-neural ectoderm || glossopharyngeal nerve || epithelial cell || facial nerve || vagus nerve || trigeminal nerve || epidermis || epithelium || epidermal cell || gastrocoel roof plate |
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0.1331 | INHERITED FROM: jaw muscle || skeletal muscle || head somite || myocyte || cranial muscle || muscle |
53901,53901 53901 - Thiolase-like 53901 - Thiolase-like | 0.1452 | INHERITED FROM: skeletal muscle |
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0.1855 | INHERITED FROM: skeletal muscle || muscle |
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.2169 | INHERITED FROM: olfactory epithelium || olfactory sensory neuron |
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat | 0.2214 | INHERITED FROM: auditory hair cell || epithelial cell || sensory epithelial cell |
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.2371 | INHERITED FROM: skeletal muscle |
103575,48726 103575 - Plexin repeat 48726 - Immunoglobulin | 0.2371 | INHERITED FROM: branchial crest || cranial neural crest || neuroectoderm || notochord || midbrain-hindbrain boundary || neural crest || cranial placode |
57440,57440 57440 - Kringle-like 57440 - Kringle-like | 0.2371 | INHERITED FROM: mesenchyme || neurogenic placode |
47031,50729 47031 - Second domain of FERM 50729 - PH domain-like | 0.2917 | INHERITED FROM: ganglion |
90229,90229 90229 - CCCH zinc finger 90229 - CCCH zinc finger | 0.3638 | INHERITED FROM: pronephric mesenchyme |
51735,56327 51735 - NAD(P)-binding Rossmann-fold domains 56327 - LDH C-terminal domain-like | 0.3778 | INHERITED FROM: connective tissue || skeletal tissue || bone tissue || skeletal muscle |
50729,56112 50729 - PH domain-like 56112 - Protein kinase-like (PK-like) | 0.3778 | INHERITED FROM: neuroectoderm || mesoderm || endoderm |
63501,50242 63501 - Frizzled cysteine-rich domain 50242 - TIMP-like | 0.3778 | INHERITED FROM: optic field || pre-chordal neural plate || neuroectoderm || neural plate || mesoderm || endoderm || stomodeal-hypophyseal primordium |
57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain | 0.4067 | INHERITED FROM: presomitic mesoderm || notochord |
81383,52047 81383 - F-box domain 52047 - RNI-like | 0.4067 | INHERITED FROM: cranial neural crest || neuroectoderm |
64593,64593 64593 - Intermediate filament protein, coiled coil region 64593 - Intermediate filament protein, coiled coil region | 0.4749 | INHERITED FROM: epidermis |
47413,46689 47413 - lambda repressor-like DNA-binding domains 46689 - Homeodomain-like | 0.4937 | INHERITED FROM: neural fold || neuroectoderm || neural plate || chordal neural plate || retinal ganglion cell layer || pronephric tubule || neurogenic placode |
57603,57603 57603 - FnI-like domain 57603 - FnI-like domain | 0.5182 | INHERITED FROM: notochord || chordal neural plate |
55486,50923 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain | 0.6322 | INHERITED FROM: notochord |
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.6973 | INHERITED FROM: sensorial layer of neurectoderm || notochord || neural groove |
49785,57184 49785 - Galactose-binding domain-like 57184 - Growth factor receptor domain | 0.6986 | INHERITED FROM: mesenchyme |
52799,52799 52799 - (Phosphotyrosine protein) phosphatases II 52799 - (Phosphotyrosine protein) phosphatases II | 0.705 | INHERITED FROM: retinal inner nuclear layer || retinal ganglion cell layer |
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) | 0.7137 | INHERITED FROM: non-involuting marginal zone |
101912,103575 101912 - Sema domain 103575 - Plexin repeat | 0.7334 | INHERITED FROM: otic placode || cranial neural crest || neuroectoderm || neural crest || cranial placode || involuted dorsal mesoderm |
47459,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) | 0.8759 | INHERITED FROM: ventral blood island |
52743,49785 52743 - Subtilisin-like 49785 - Galactose-binding domain-like | 0.8997 | INHERITED FROM: notochord |
56112,47769 56112 - Protein kinase-like (PK-like) 47769 - SAM/Pointed domain | 0.8997 | INHERITED FROM: branchial crest || cranial neural crest || mesenchyme |
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III | 0.9101 | INHERITED FROM: retinal inner nuclear layer |
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.9559 | INHERITED FROM: pre-chordal neural plate || anterior neural fold || neural fold || pre-chordal neural plate border || neuroectoderm || chordal neural plate border || neural plate || lateral plate mesoderm || chordal neural plate || splanchnic layer of lateral plate mesoderm || neural plate border || anterior neural ridge |
49313,49313 49313 - Cadherin-like 49313 - Cadherin-like | 1 | INHERITED FROM: neural crest |
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III | 1 | INHERITED FROM: retinal inner nuclear layer || retinal ganglion cell layer |
50044,55550 50044 - SH3-domain 55550 - SH2 domain | 1 | INHERITED FROM: non-involuting marginal zone |
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin | 1 | INHERITED FROM: wound epidermis |
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57938,49493 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
81995,81811 81995 - beta-sandwich domain of Sec23/24 81811 - Helical domain of Sec23/24 | 0 | Direct |
57630,57196 57630 - GLA-domain 57196 - EGF/Laminin | 0 | Direct |
57196,50494 57196 - EGF/Laminin 50494 - Trypsin-like serine proteases | 0 | Direct |
52058,57184 52058 - L domain-like 57184 - Growth factor receptor domain | 0 | Direct |
103647,103647 103647 - TSP type-3 repeat 103647 - TSP type-3 repeat | 0 | Direct |
57184,49265 57184 - Growth factor receptor domain 49265 - Fibronectin type III | 0 | Direct |
54452,48726 54452 - MHC antigen-recognition domain 48726 - Immunoglobulin | 0 | Direct |
47661,58038 47661 - t-snare proteins 58038 - SNARE fusion complex | 0 | Direct |
47587,56399 47587 - Domain of poly(ADP-ribose) polymerase 56399 - ADP-ribosylation | 0 | Direct |
69012,55874 69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
46966,47473 46966 - Spectrin repeat 47473 - EF-hand | 0 | Direct |
82895,57424 82895 - TSP-1 type 1 repeat 57424 - LDL receptor-like module | 0 | Direct |
56059,52210 56059 - Glutathione synthetase ATP-binding domain-like 52210 - Succinyl-CoA synthetase domains | 0 | Direct |
53738,55957 53738 - Phosphoglucomutase, first 3 domains 55957 - Phosphoglucomutase, C-terminal domain | 0 | Direct |
100895,47473 100895 - Kazal-type serine protease inhibitors 47473 - EF-hand | 0 | Direct |
53223,51735 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
54534,54534 54534 - FKBP-like 54534 - FKBP-like | 0 | Direct |
56645,47203 56645 - Acyl-CoA dehydrogenase NM domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
110324,50249 110324 - Ribosomal L27 protein-like 50249 - Nucleic acid-binding proteins | 0 | Direct |
81296,48239 81296 - E set domains 48239 - Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
49854,57196 49854 - Spermadhesin, CUB domain 57196 - EGF/Laminin | 0 | Direct |
48726,56436 48726 - Immunoglobulin 56436 - C-type lectin-like | 0 | Direct |
47459,158457 47459 - HLH, helix-loop-helix DNA-binding domain 158457 - Orange domain-like | 0 | Direct |
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like | 0 | Direct |
55486,48371 55486 - Metalloproteases ("zincins"), catalytic domain 48371 - ARM repeat | 0 | Direct |
55550,55550 55550 - SH2 domain 55550 - SH2 domain | 0 | Direct |
54511,57184 54511 - GFP-like 57184 - Growth factor receptor domain | 0 | Direct |
47095,47095 47095 - HMG-box 47095 - HMG-box | 0 | Direct |
142921,47587 142921 - WGR domain-like 47587 - Domain of poly(ADP-ribose) polymerase | 0 | Direct |
81811,82754 81811 - Helical domain of Sec23/24 82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
53732,52016 53732 - Aconitase iron-sulfur domain 52016 - LeuD/IlvD-like | 0 | Direct |
52518,52922 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52922 - TK C-terminal domain-like | 0 | Direct |
52425,48173 52425 - Cryptochrome/photolyase, N-terminal domain 48173 - Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
46565,57938 46565 - Chaperone J-domain 57938 - DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
117018,56091 117018 - ATP-dependent DNA ligase DNA-binding domain 56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
57196,56436 57196 - EGF/Laminin 56436 - C-type lectin-like | 0 | Direct |
52777,52777 52777 - CoA-dependent acyltransferases 52777 - CoA-dependent acyltransferases | 0 | Direct |
52518,52518 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
82109,82109 82109 - MIR domain 82109 - MIR domain | 0 | Direct |
49899,52540 49899 - Concanavalin A-like lectins/glucanases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
90209,90209 90209 - Ran binding protein zinc finger-like 90209 - Ran binding protein zinc finger-like | 0 | Direct |
52540,53254 52540 - P-loop containing nucleoside triphosphate hydrolases 53254 - Phosphoglycerate mutase-like | 0 | Direct |
52540,48019 52540 - P-loop containing nucleoside triphosphate hydrolases 48019 - post-AAA+ oligomerization domain-like | 0 | Direct |
81301,81631 81301 - Nucleotidyltransferase 81631 - PAP/OAS1 substrate-binding domain | 0 | Direct |
57196,90193 57196 - EGF/Laminin 90193 - Notch domain | 0 | Direct |
54211,55060 54211 - Ribosomal protein S5 domain 2-like 55060 - GHMP Kinase, C-terminal domain | 0 | Direct |
49348,55711 49348 - Clathrin adaptor appendage domain 55711 - Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
90257,90257 90257 - Myosin rod fragments 90257 - Myosin rod fragments | 0 | Direct |
56436,57535 56436 - C-type lectin-like 57535 - Complement control module/SCR domain | 0 | Direct |
103647,49899 103647 - TSP type-3 repeat 49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
53738,53738 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains | 0 | Direct |
46785,144074 46785 - "Winged helix" DNA-binding domain 144074 - E2F-DP heterodimerization region | 0 | Direct |
47473,103506 47473 - EF-hand 103506 - Mitochondrial carrier | 0 | Direct |
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
51230,47005 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
51419,50621 51419 - PLP-binding barrel 50621 - Alanine racemase C-terminal domain-like | 0 | Direct |
51045,56204 51045 - WW domain 56204 - Hect, E3 ligase catalytic domain | 0 | Direct |
54236,57889 54236 - Ubiquitin-like 57889 - Cysteine-rich domain | 0 | Direct |
47005,52777 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 52777 - CoA-dependent acyltransferases | 0 | Direct |
47203,47203 47203 - Acyl-CoA dehydrogenase C-terminal domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
57196,100895 57196 - EGF/Laminin 100895 - Kazal-type serine protease inhibitors | 0 | Direct |
55021,56534 55021 - ACT-like 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
57756,57756 57756 - Retrovirus zinc finger-like domains 57756 - Retrovirus zinc finger-like domains | 0 | Direct |
54160,57850 54160 - Chromo domain-like 57850 - RING/U-box | 0 | Direct |
47370,47370 47370 - Bromodomain 47370 - Bromodomain | 0 | Direct |
57903,47370 57903 - FYVE/PHD zinc finger 47370 - Bromodomain | 0 | Direct |
49493,49493 49493 - HSP40/DnaJ peptide-binding domain 49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
54403,54403 54403 - Cystatin/monellin 54403 - Cystatin/monellin | 0 | Direct |
82153,82153 82153 - FAS1 domain 82153 - FAS1 domain | 0 | Direct |
52540,46785 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain | 0 | Direct |
82615,82615 82615 - Polo-box domain 82615 - Polo-box domain | 0 | Direct |
47220,47220 47220 - alpha-catenin/vinculin-like 47220 - alpha-catenin/vinculin-like | 0 | Direct |
50044,50156 50044 - SH3-domain 50156 - PDZ domain-like | 0 | Direct |
88723,47807 88723 - PIN domain-like 47807 - 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
53300,81995 53300 - vWA-like 81995 - beta-sandwich domain of Sec23/24 | 0 | Direct |
48034,55931 48034 - Guanido kinase N-terminal domain 55931 - Glutamine synthetase/guanido kinase | 0 | Direct |
82919,53300 82919 - Zn-finger domain of Sec23/24 53300 - vWA-like | 0 | Direct |
161111,160240 161111 - Cation efflux protein transmembrane domain-like 160240 - Cation efflux protein cytoplasmic domain-like | 0 | Direct |
82109,100909 82109 - MIR domain 100909 - IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
57184,57610 57184 - Growth factor receptor domain 57610 - Thyroglobulin type-1 domain | 0 | Direct |
54211,55666 54211 - Ribosomal protein S5 domain 2-like 55666 - Ribonuclease PH domain 2-like | 0 | Direct |
81698,81698 81698 - FF domain 81698 - FF domain | 0 | Direct |
63411,63411 63411 - LuxS/MPP-like metallohydrolase 63411 - LuxS/MPP-like metallohydrolase | 0 | Direct |
57184,100895 57184 - Growth factor receptor domain 100895 - Kazal-type serine protease inhibitors | 0 | Direct |
52058,49265 52058 - L domain-like 49265 - Fibronectin type III | 0 | Direct |
56091,50249 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins | 0 | Direct |
57184,52058 57184 - Growth factor receptor domain 52058 - L domain-like | 0 | Direct |
48371,46785 48371 - ARM repeat 46785 - "Winged helix" DNA-binding domain | 0 | Direct |
54631,54631 54631 - CBS-domain pair 54631 - CBS-domain pair | 0 | Direct |
54928,54928 54928 - RNA-binding domain, RBD 54928 - RNA-binding domain, RBD | 0.00001658 | Direct |
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.003939 | Inherited |
54791,54791 54791 - Eukaryotic type KH-domain (KH-domain type I) 54791 - Eukaryotic type KH-domain (KH-domain type I) | 0.02296 | Inherited |
47954,47954 47954 - Cyclin-like 47954 - Cyclin-like | 0.0744 | Inherited |
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.08778 | Inherited |
52490,55307 52490 - Tubulin nucleotide-binding domain-like 55307 - Tubulin C-terminal domain-like | 0.1211 | Inherited |
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0.1331 | Inherited |
53901,53901 53901 - Thiolase-like 53901 - Thiolase-like | 0.1452 | Inherited |
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0.1855 | Inherited |
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.2169 | Inherited |
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat | 0.2214 | Inherited |
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.2371 | Inherited |
103575,48726 103575 - Plexin repeat 48726 - Immunoglobulin | 0.2371 | Inherited |
57440,57440 57440 - Kringle-like 57440 - Kringle-like | 0.2371 | Inherited |
47031,50729 47031 - Second domain of FERM 50729 - PH domain-like | 0.2917 | Inherited |
90229,90229 90229 - CCCH zinc finger 90229 - CCCH zinc finger | 0.3638 | Inherited |
51735,56327 51735 - NAD(P)-binding Rossmann-fold domains 56327 - LDH C-terminal domain-like | 0.3778 | Inherited |
50729,56112 50729 - PH domain-like 56112 - Protein kinase-like (PK-like) | 0.3778 | Inherited |
63501,50242 63501 - Frizzled cysteine-rich domain 50242 - TIMP-like | 0.3778 | Inherited |
57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain | 0.4067 | Inherited |
81383,52047 81383 - F-box domain 52047 - RNI-like | 0.4067 | Inherited |
64593,64593 64593 - Intermediate filament protein, coiled coil region 64593 - Intermediate filament protein, coiled coil region | 0.4749 | Inherited |
47413,46689 47413 - lambda repressor-like DNA-binding domains 46689 - Homeodomain-like | 0.4937 | Inherited |
57603,57603 57603 - FnI-like domain 57603 - FnI-like domain | 0.5182 | Inherited |
55486,50923 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain | 0.6322 | Inherited |
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.6973 | Inherited |
49785,57184 49785 - Galactose-binding domain-like 57184 - Growth factor receptor domain | 0.6986 | Inherited |
52799,52799 52799 - (Phosphotyrosine protein) phosphatases II 52799 - (Phosphotyrosine protein) phosphatases II | 0.705 | Inherited |
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) | 0.7137 | Inherited |
101912,103575 101912 - Sema domain 103575 - Plexin repeat | 0.7334 | Inherited |
47459,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) | 0.8759 | Inherited |
52743,49785 52743 - Subtilisin-like 49785 - Galactose-binding domain-like | 0.8997 | Inherited |
56112,47769 56112 - Protein kinase-like (PK-like) 47769 - SAM/Pointed domain | 0.8997 | Inherited |
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III | 0.9101 | Inherited |
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.9559 | Inherited |
49313,49313 49313 - Cadherin-like 49313 - Cadherin-like | 1 | Inherited |
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III | 1 | Inherited |
50044,55550 50044 - SH3-domain 55550 - SH2 domain | 1 | Inherited |
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin | 1 | Inherited |
(show details)
Supra-domains annotated to this XA term (SPXA level: Least Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47769,47769,47769 47769 - SAM/Pointed domain 47769 - SAM/Pointed domain 47769 - SAM/Pointed domain | 0 | DIRECT |
48726,56436,56436 48726 - Immunoglobulin 56436 - C-type lectin-like 56436 - C-type lectin-like | 0 | DIRECT |
57196,57184,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain | 0 | DIRECT |
103647,103647,49899 103647 - TSP type-3 repeat 103647 - TSP type-3 repeat 49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57630,57196,57196 57630 - GLA-domain 57196 - EGF/Laminin 57196 - EGF/Laminin | 0 | DIRECT |
63737,55486,48371 63737 - Leukotriene A4 hydrolase N-terminal domain 55486 - Metalloproteases ("zincins"), catalytic domain 48371 - ARM repeat | 0 | DIRECT |
46966,46966,47473 46966 - Spectrin repeat 46966 - Spectrin repeat 47473 - EF-hand | 0 | DIRECT |
90257,90257,90257 90257 - Myosin rod fragments 90257 - Myosin rod fragments 90257 - Myosin rod fragments | 0 | DIRECT |
81995,81811,82754 81995 - beta-sandwich domain of Sec23/24 81811 - Helical domain of Sec23/24 82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
103647,103647,103647 103647 - TSP type-3 repeat 103647 - TSP type-3 repeat 103647 - TSP type-3 repeat | 0 | DIRECT |
57184,52058,49265 57184 - Growth factor receptor domain 52058 - L domain-like 49265 - Fibronectin type III | 0 | DIRECT |
52058,57184,52058 52058 - L domain-like 57184 - Growth factor receptor domain 52058 - L domain-like | 0 | DIRECT |
57184,52058,57184 57184 - Growth factor receptor domain 52058 - L domain-like 57184 - Growth factor receptor domain | 0 | DIRECT |
82109,82109,100909 82109 - MIR domain 82109 - MIR domain 100909 - IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
57184,57196,57196 57184 - Growth factor receptor domain 57196 - EGF/Laminin 57196 - EGF/Laminin | 0 | DIRECT |
57938,49493,49493 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain 49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
54791,54791,54791 54791 - Eukaryotic type KH-domain (KH-domain type I) 54791 - Eukaryotic type KH-domain (KH-domain type I) 54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
53738,53738,55957 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains 55957 - Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
47220,47220,47220 47220 - alpha-catenin/vinculin-like 47220 - alpha-catenin/vinculin-like 47220 - alpha-catenin/vinculin-like | 0 | DIRECT |
53300,81995,81811 53300 - vWA-like 81995 - beta-sandwich domain of Sec23/24 81811 - Helical domain of Sec23/24 | 0 | DIRECT |
57196,49854,57535 57196 - EGF/Laminin 49854 - Spermadhesin, CUB domain 57535 - Complement control module/SCR domain | 0 | DIRECT |
52058,49265,49265 52058 - L domain-like 49265 - Fibronectin type III 49265 - Fibronectin type III | 0 | DIRECT |
51230,47005,52777 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 52777 - CoA-dependent acyltransferases | 0 | DIRECT |
51338,51556,51338 51338 - Composite domain of metallo-dependent hydrolases 51556 - Metallo-dependent hydrolases 51338 - Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
57184,57184,57196 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain 57196 - EGF/Laminin | 0 | DIRECT |
117018,56091,50249 117018 - ATP-dependent DNA ligase DNA-binding domain 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins | 0 | DIRECT |
54511,57184,57184 54511 - GFP-like 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain | 0 | DIRECT |
142921,47587,56399 142921 - WGR domain-like 47587 - Domain of poly(ADP-ribose) polymerase 56399 - ADP-ribosylation | 0 | DIRECT |
50249,50249,50249 50249 - Nucleic acid-binding proteins 50249 - Nucleic acid-binding proteins 50249 - Nucleic acid-binding proteins | 0 | DIRECT |
51045,51045,56204 51045 - WW domain 51045 - WW domain 56204 - Hect, E3 ligase catalytic domain | 0 | DIRECT |
46565,57938,49493 46565 - Chaperone J-domain 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
57196,57196,49899 57196 - EGF/Laminin 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57196,49899,57196 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases 57196 - EGF/Laminin | 0 | DIRECT |
49785,49785,49899 49785 - Galactose-binding domain-like 49785 - Galactose-binding domain-like 49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
48592,54849,52029 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0 | DIRECT |
56645,47203,47203 56645 - Acyl-CoA dehydrogenase NM domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
54160,57850,57845 54160 - Chromo domain-like 57850 - RING/U-box 57845 - B-box zinc-binding domain | 0 | DIRECT |
54768,54768,54768 54768 - dsRNA-binding domain-like 54768 - dsRNA-binding domain-like 54768 - dsRNA-binding domain-like | 0 | DIRECT |
57440,57440,57440 57440 - Kringle-like 57440 - Kringle-like 57440 - Kringle-like | 0 | DIRECT |
49854,57196,49854 49854 - Spermadhesin, CUB domain 57196 - EGF/Laminin 49854 - Spermadhesin, CUB domain | 0 | DIRECT |
53738,53738,53738 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains | 0 | DIRECT |
52833,52833,52833 52833 - Thioredoxin-like 52833 - Thioredoxin-like 52833 - Thioredoxin-like | 0 | DIRECT |
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.08778 | INHERITED FROM: skeletal muscle |
48371,48371,48371 48371 - ARM repeat 48371 - ARM repeat 48371 - ARM repeat | 0.1423 | INHERITED FROM: chordoneural hinge || trunk somite || tail somite || tail tip |
46966,46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat 46966 - Spectrin repeat | 0.2169 | INHERITED FROM: auditory hair cell || epithelial cell || sensory epithelial cell |
101912,103575,48726 101912 - Sema domain 103575 - Plexin repeat 48726 - Immunoglobulin | 0.2371 | INHERITED FROM: branchial crest || cranial neural crest || neuroectoderm || notochord || midbrain-hindbrain boundary || neural crest || cranial placode |
53067,100920,100934 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.2371 | INHERITED FROM: skeletal muscle |
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.2816 | INHERITED FROM: notochord || non-neurogenic ectodermal placode |
57603,57603,57603 57603 - FnI-like domain 57603 - FnI-like domain 57603 - FnI-like domain | 0.2988 | INHERITED FROM: notochord |
50044,55550,56112 50044 - SH3-domain 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) | 0.3739 | INHERITED FROM: pre-chordal neural plate || anterior neural fold || neural fold || non-involuting marginal zone || neuroectoderm || neural plate || mesoderm || otic vesicle |
57196,57196,57184 57196 - EGF/Laminin 57196 - EGF/Laminin 57184 - Growth factor receptor domain | 0.3739 | INHERITED FROM: sensorial layer of neurectoderm || anterior neural fold || presomitic mesoderm || anterior placodal area || tail tip |
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.5416 | INHERITED FROM: retinal inner nuclear layer || retinal ganglion cell layer |
49899,49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0.7284 | INHERITED FROM: notochord |
49313,49313,49313 49313 - Cadherin-like 49313 - Cadherin-like 49313 - Cadherin-like | 1 | INHERITED FROM: neuroectoderm || neural crest |
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin | 1 | INHERITED FROM: pharyngeal mesenchyme || wound epidermis |
57667,57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 1 | INHERITED FROM: splanchnic layer of lateral plate mesoderm |
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47769,47769,47769 47769 - SAM/Pointed domain 47769 - SAM/Pointed domain 47769 - SAM/Pointed domain | 0 | Direct |
48726,56436,56436 48726 - Immunoglobulin 56436 - C-type lectin-like 56436 - C-type lectin-like | 0 | Direct |
57196,57184,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain | 0 | Direct |
103647,103647,49899 103647 - TSP type-3 repeat 103647 - TSP type-3 repeat 49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57630,57196,57196 57630 - GLA-domain 57196 - EGF/Laminin 57196 - EGF/Laminin | 0 | Direct |
63737,55486,48371 63737 - Leukotriene A4 hydrolase N-terminal domain 55486 - Metalloproteases ("zincins"), catalytic domain 48371 - ARM repeat | 0 | Direct |
46966,46966,47473 46966 - Spectrin repeat 46966 - Spectrin repeat 47473 - EF-hand | 0 | Direct |
90257,90257,90257 90257 - Myosin rod fragments 90257 - Myosin rod fragments 90257 - Myosin rod fragments | 0 | Direct |
81995,81811,82754 81995 - beta-sandwich domain of Sec23/24 81811 - Helical domain of Sec23/24 82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
103647,103647,103647 103647 - TSP type-3 repeat 103647 - TSP type-3 repeat 103647 - TSP type-3 repeat | 0 | Direct |
57184,52058,49265 57184 - Growth factor receptor domain 52058 - L domain-like 49265 - Fibronectin type III | 0 | Direct |
52058,57184,52058 52058 - L domain-like 57184 - Growth factor receptor domain 52058 - L domain-like | 0 | Direct |
57184,52058,57184 57184 - Growth factor receptor domain 52058 - L domain-like 57184 - Growth factor receptor domain | 0 | Direct |
82109,82109,100909 82109 - MIR domain 82109 - MIR domain 100909 - IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
57184,57196,57196 57184 - Growth factor receptor domain 57196 - EGF/Laminin 57196 - EGF/Laminin | 0 | Direct |
57938,49493,49493 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain 49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
54791,54791,54791 54791 - Eukaryotic type KH-domain (KH-domain type I) 54791 - Eukaryotic type KH-domain (KH-domain type I) 54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
53738,53738,55957 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains 55957 - Phosphoglucomutase, C-terminal domain | 0 | Direct |
47220,47220,47220 47220 - alpha-catenin/vinculin-like 47220 - alpha-catenin/vinculin-like 47220 - alpha-catenin/vinculin-like | 0 | Direct |
53300,81995,81811 53300 - vWA-like 81995 - beta-sandwich domain of Sec23/24 81811 - Helical domain of Sec23/24 | 0 | Direct |
57196,49854,57535 57196 - EGF/Laminin 49854 - Spermadhesin, CUB domain 57535 - Complement control module/SCR domain | 0 | Direct |
52058,49265,49265 52058 - L domain-like 49265 - Fibronectin type III 49265 - Fibronectin type III | 0 | Direct |
51230,47005,52777 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 52777 - CoA-dependent acyltransferases | 0 | Direct |
51338,51556,51338 51338 - Composite domain of metallo-dependent hydrolases 51556 - Metallo-dependent hydrolases 51338 - Composite domain of metallo-dependent hydrolases | 0 | Direct |
57184,57184,57196 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain 57196 - EGF/Laminin | 0 | Direct |
117018,56091,50249 117018 - ATP-dependent DNA ligase DNA-binding domain 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins | 0 | Direct |
54511,57184,57184 54511 - GFP-like 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain | 0 | Direct |
142921,47587,56399 142921 - WGR domain-like 47587 - Domain of poly(ADP-ribose) polymerase 56399 - ADP-ribosylation | 0 | Direct |
50249,50249,50249 50249 - Nucleic acid-binding proteins 50249 - Nucleic acid-binding proteins 50249 - Nucleic acid-binding proteins | 0 | Direct |
51045,51045,56204 51045 - WW domain 51045 - WW domain 56204 - Hect, E3 ligase catalytic domain | 0 | Direct |
46565,57938,49493 46565 - Chaperone J-domain 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
57196,57196,49899 57196 - EGF/Laminin 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57196,49899,57196 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases 57196 - EGF/Laminin | 0 | Direct |
49785,49785,49899 49785 - Galactose-binding domain-like 49785 - Galactose-binding domain-like 49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
48592,54849,52029 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0 | Direct |
56645,47203,47203 56645 - Acyl-CoA dehydrogenase NM domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
54160,57850,57845 54160 - Chromo domain-like 57850 - RING/U-box 57845 - B-box zinc-binding domain | 0 | Direct |
54768,54768,54768 54768 - dsRNA-binding domain-like 54768 - dsRNA-binding domain-like 54768 - dsRNA-binding domain-like | 0 | Direct |
57440,57440,57440 57440 - Kringle-like 57440 - Kringle-like 57440 - Kringle-like | 0 | Direct |
49854,57196,49854 49854 - Spermadhesin, CUB domain 57196 - EGF/Laminin 49854 - Spermadhesin, CUB domain | 0 | Direct |
53738,53738,53738 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains | 0 | Direct |
52833,52833,52833 52833 - Thioredoxin-like 52833 - Thioredoxin-like 52833 - Thioredoxin-like | 0 | Direct |
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.08778 | Inherited |
48371,48371,48371 48371 - ARM repeat 48371 - ARM repeat 48371 - ARM repeat | 0.1423 | Inherited |
46966,46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat 46966 - Spectrin repeat | 0.2169 | Inherited |
101912,103575,48726 101912 - Sema domain 103575 - Plexin repeat 48726 - Immunoglobulin | 0.2371 | Inherited |
53067,100920,100934 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.2371 | Inherited |
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.2816 | Inherited |
57603,57603,57603 57603 - FnI-like domain 57603 - FnI-like domain 57603 - FnI-like domain | 0.2988 | Inherited |
50044,55550,56112 50044 - SH3-domain 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) | 0.3739 | Inherited |
57196,57196,57184 57196 - EGF/Laminin 57196 - EGF/Laminin 57184 - Growth factor receptor domain | 0.3739 | Inherited |
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.5416 | Inherited |
49899,49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0.7284 | Inherited |
49313,49313,49313 49313 - Cadherin-like 49313 - Cadherin-like 49313 - Cadherin-like | 1 | Inherited |
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin | 1 | Inherited |
57667,57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 1 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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