•  SEARCH

  • Keyword search
  • Sequence search
• 
  

•  BROWSE

  •   Organisms
  • Taxonomy
  • Statistics
  •   SCOP
  • Hierarchy
  •   Ontologies
  • GO
  • EC
  • Phenotype
• 
  

•  TOOLS

  • Compare genomes
  • Phylogenetic trees
  • Web services
  • Downloads
• 
  

•  ABOUT

  • Description
  • Publications
  • Documentation
• 
  

•  HELP

  • User support
  • Contact us
  • Email list
  • Sitemap

Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

• Disease Ontology (DO) Ontology (DO)
  DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
  
• Human Phenotype (HP) Ontology (HP)
  HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
  
• Mouse Phenotype (MP) Ontology (MP)
  MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
  
• Worm Phenotype (WP) Ontology (WP)
  WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
  
• Yeast Phenotype (YP) Ontology (YP)
  Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
  
• Fly Phenotype (FP) Ontology (FP)
  FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
  
• Fly Anatomy (FA) Ontology (FA)
  FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
  
• Zebrafish Anatomy (ZA) Ontology (ZA)
  ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
  
• Xenopus Anatomy (XA) Ontology (XA)
  XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
  
• Arabidopsis Plant Ontology (AP) Ontology (AP)
  As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
  
• Enzyme Commission (EC) Ontology (EC)
  Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
  
• DrugBank ATC (DB) Ontology (DB)
  In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
  
• UniProtKB KeyWords (KW) Ontology (KW)
  Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
  
• UniProtKB UniPathway (UP) Ontology (UP)
  UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
  

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
  

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
  

Superfamily domains annotated to this XA term (SDXA level: Least Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Nucleoplasmin-like core domain	0	DIRECT
FAS1 domain	0	DIRECT
Mitochondrial cytochrome c oxidase subunit VIIa	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
BSD domain-like	0	DIRECT
SPOC domain-like	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
Class I glutamine amidotransferase-like	0	DIRECT
NAP-like	0	DIRECT
Alanine racemase C-terminal domain-like	0	DIRECT
Sialidases	0	DIRECT
Troponin coil-coiled subunits	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
Subdomain of clathrin and coatomer appendage domain	0	DIRECT
GINS helical bundle-like	0	DIRECT
Soluble quinoprotein glucose dehydrogenase	0	DIRECT
Cytokine	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
KA1-like	0	DIRECT
Alpha-macroglobulin receptor domain	0	DIRECT
BRK domain-like	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Acyl-CoA dehydrogenase NM domain-like	0	DIRECT
Bromodomain	0	DIRECT
Orange domain-like	0	DIRECT
PLP-binding barrel	0	DIRECT
ADP-ribosylglycohydrolase	0	DIRECT
GFP-like	0	DIRECT
Cryptochrome/photolyase FAD-binding domain	0	DIRECT
Ribosomal proteins L15p and L18e	0	DIRECT
FMT C-terminal domain-like	0	DIRECT
WGR domain-like	0	DIRECT
Aconitase iron-sulfur domain	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
SMAD MH1 domain	0	DIRECT
PAH2 domain	0	DIRECT
LuxS/MPP-like metallohydrolase	0	DIRECT
Cap-Gly domain	0	DIRECT
PriA/YqbF domain	0	DIRECT
IP3 receptor type 1 binding core, domain 2	0	DIRECT
Apolipoprotein A-I	0	DIRECT
G protein-binding domain	0	DIRECT
Ferritin-like	0	DIRECT
Trefoil	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
Tim10-like	0	DIRECT
Mediator hinge subcomplex-like	0	DIRECT
L-aspartase-like	0	DIRECT
Acyl-CoA dehydrogenase C-terminal domain-like	0	DIRECT
Clathrin adaptor appendage domain	0	DIRECT
SRF-like	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
SIS domain	0	DIRECT
Fibrinogen coiled-coil and central regions	0	DIRECT
Endosomal sorting complex assembly domain	0	DIRECT
Sec63 N-terminal domain-like	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
SAP domain	0	DIRECT
E2F-DP heterodimerization region	0	DIRECT
Subunits of heterodimeric actin filament capping protein Capz	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
alpha-catenin/vinculin-like	0	DIRECT
TSP type-3 repeat	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
GYF domain	0	DIRECT
DLC	0	DIRECT
FF domain	0	DIRECT
Connexin43	0	DIRECT
Nop domain	0	DIRECT
TAFH domain-like	0	DIRECT
Isocitrate/Isopropylmalate dehydrogenase-like	0	DIRECT
LeuD/IlvD-like	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
Aminoacid dehydrogenase-like, N-terminal domain	0	DIRECT
C-terminal domain of adenylylcyclase associated protein	0	DIRECT
CoA-dependent acyltransferases	0	DIRECT
Notch domain	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
Delta-sleep-inducing peptide immunoreactive peptide	0	DIRECT
HRDC-like	0	DIRECT
Cryptochrome/photolyase, N-terminal domain	0	DIRECT
TK C-terminal domain-like	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
Zn-binding ribosomal proteins	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Translation proteins SH3-like domain	0	DIRECT
Myosin phosphatase inhibitor 17kDa protein, CPI-17	0	DIRECT
14-3-3 protein	0	DIRECT
Mib/herc2 domain-like	0	DIRECT
Ribosomal L27 protein-like	0	DIRECT
N-acetylmuramoyl-L-alanine amidase-like	0	DIRECT
4Fe-4S ferredoxins	0	DIRECT
DNA ligase/mRNA capping enzyme, catalytic domain	0	DIRECT
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	0	DIRECT
Moesin tail domain	0	DIRECT
BAG domain	0	DIRECT
Arginase/deacetylase	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
NTF2-like	0	DIRECT
Proteasome activator	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
PEBP-like	0	DIRECT
eIF4e-like	0	DIRECT
Ribosomal proteins S24e, L23 and L15e	0	DIRECT
Synuclein	0	DIRECT
PAP/OAS1 substrate-binding domain	0	DIRECT
Uracil-DNA glycosylase-like	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Hedgehog/DD-peptidase	0	DIRECT
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
ATP-dependent DNA ligase DNA-binding domain	0	DIRECT
Nucleoporin domain	0	DIRECT
alpha-ketoacid dehydrogenase kinase, N-terminal domain	0	DIRECT
Di-copper centre-containing domain	0	DIRECT
post-AAA+ oligomerization domain-like	0	DIRECT
Ribulose-phoshate binding barrel	0	DIRECT
MIR domain	0	DIRECT
RNA-binding domain, RBD	0.000004542	DIRECT
Homeodomain-like	0.00001111	DIRECT
"Winged helix" DNA-binding domain	0.00004771	DIRECT
Nucleic acid-binding proteins	0.0002581	DIRECT
HLH, helix-loop-helix DNA-binding domain	0.0003919	DIRECT
UBC-like	0.01607	INHERITED FROM: bone tissue
Thioredoxin-like	0.02091	INHERITED FROM: early proximal tubule || connective tissue || bone tissue || skeletal tissue
Cyclin-like	0.02537	INHERITED FROM: postmigratory neural crest cell
SET domain	0.03878	INHERITED FROM: primary germ layer
Actin depolymerizing proteins	0.05426	INHERITED FROM: connective tissue || bone tissue || skeletal tissue
HSP20-like chaperones	0.0589	INHERITED FROM: skeletal muscle
HMG-box	0.06139	INHERITED FROM: mandibular crest || neural plate || neuroectoderm outer layer || endocardium || posterior branchial crest || midbrain-hindbrain boundary || neural fold || hyoid crest || retinal layer || blastocoel floor || endoderm || optic field || anterior neural fold || pre-chordal neural plate || anterior branchial crest || neurogenic placode || neural crest || neuroectoderm || neural plate border || cranial neural crest || otic vesicle || chordal neural plate
ARID-like	0.1027	INHERITED FROM: pronephric tubule
Heat shock protein 70kD (HSP70), peptide-binding domain	0.1027	INHERITED FROM: skeletal muscle
Glucocorticoid receptor-like (DNA-binding domain)	0.1149	INHERITED FROM: zona limitans intrathalamica || proximal tubule branch || preplacodal ectoderm || anterior placodal area || cranial placode || sensorial layer of neurectoderm || archenteron floor || neuroectoderm
GroEL equatorial domain-like	0.1235	INHERITED FROM: endomesoderm || anterior dorsal lateral plate region || skeletal muscle || muscle
Actin-like ATPase domain	0.1279	INHERITED FROM: skeletal muscle || myocyte || head somite || jaw muscle || cranial muscle
p53-like transcription factors	0.1348	INHERITED FROM: neural plate || mesoderm || mesenchyme || cranial placode || facial nerve || cartilage tissue || neurogenic placode || involuted ventral mesoderm || neuroectoderm || myocardium || regenerating tissue || blastema || notochord || primary heart field
Tubulin C-terminal domain-like	0.1385	INHERITED FROM: trigeminal nerve || vagus nerve || epidermis || gastrocoel roof plate || glossopharyngeal nerve || facial nerve || epithelium || epithelial cell || epidermal cell || non-neural ectoderm
GroEL-intermediate domain like	0.1655	INHERITED FROM: endomesoderm || anterior dorsal lateral plate region || skeletal muscle || muscle
Thiolase-like	0.1655	INHERITED FROM: skeletal muscle
Transducin (alpha subunit), insertion domain	0.2407	INHERITED FROM: olfactory epithelium || olfactory sensory neuron
Spectrin repeat	0.2409	INHERITED FROM: auditory hair cell || sensory epithelial cell || epithelial cell
Tubulin nucleotide-binding domain-like	0.2599	INHERITED FROM: trigeminal nerve || vagus nerve || epidermis || gastrocoel roof plate || glossopharyngeal nerve || facial nerve || epithelium || epithelial cell || epidermal cell || non-neural ectoderm
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.2659	INHERITED FROM: skeletal muscle
Hemopexin-like domain	0.3017	INHERITED FROM: mesodermal cell || fibroblast || notochord
GroEL apical domain-like	0.3252	INHERITED FROM: anterior dorsal lateral plate region || skeletal muscle || muscle
Myosin rod fragments	0.35	INHERITED FROM: musculature of face
SMAD/FHA domain	0.355	INHERITED FROM: endocardium
Frizzled cysteine-rich domain	0.3607	INHERITED FROM: somite || lateral plate mesoderm || neural plate || mesoderm || tail tip || midbrain-hindbrain boundary || neural fold || mesenchyme || mouth primordium || endoderm || optic field || presomitic mesoderm || anterior neural fold || pre-chordal neural plate || presumptive paraxial mesoderm || stomodeal-hypophyseal primordium || neuroectoderm || involuted dorsal mesoderm || otic vesicle || tail fin
Clavaminate synthase-like	0.3776	INHERITED FROM: late proximal tubule || late distal tubule
Phosphoglycerate mutase-like	0.3823	INHERITED FROM: mesenchyme || head mesenchyme || notochord
Annexin	0.4029	INHERITED FROM: bone tissue
LDH C-terminal domain-like	0.4084	INHERITED FROM: connective tissue || bone tissue || skeletal tissue
Intermediate filament protein, coiled coil region	0.4135	INHERITED FROM: retinal ganglion cell layer || retinal inner plexiform layer || retinal inner nuclear layer || retinal ganglion cell || cephalic nerve || ganglion || epidermis || spinal ganglion || optic nerve || epithelium || regenerating tissue || blastema || nerve
Cystine-knot cytokines	0.4371	INHERITED FROM: secondary heart field || head mesoderm || vegetal endoderm || mesoderm || neural groove || mesenchyme || mouth primordium || endoderm || ventral mesoderm || head mesenchyme || neurogenic placode || neuroectoderm || involuted dorsal mesoderm || regenerating tissue || blastema || notochord || primary heart field || involuting marginal zone mesenchymal layer
PGBD-like	0.4628	INHERITED FROM: notochordal sheath || notochord
lambda repressor-like DNA-binding domains	0.5099	INHERITED FROM: neural plate || proximal tubule || early distal tubule || neural fold || pronephric tubule || cranial placode || pronephric mesenchyme || neurogenic placode || neuroectoderm || distal tubule || late distal tubule || chordal neural plate
Kringle-like	0.5697	INHERITED FROM: neural groove || epithelium
FnI-like domain	0.5777	INHERITED FROM: somite || hypochord || endoderm || epithelial cell || notochord
Globin-like	0.6385	INHERITED FROM: anterior dorsal lateral plate region || ventral blood island || hematopoietic stem cell || anterior ventral blood island
Growth factor receptor domain	0.655	INHERITED FROM: fin || pre-chordal neural plate border || anterior neural ridge || hypochord || tail tip || mesenchyme || notochord || otic vesicle
TIMP-like	0.6949	INHERITED FROM: endoderm || optic field || pre-chordal neural plate || stomodeal-hypophyseal primordium
Snake toxin-like	0.698	INHERITED FROM: lateral plate mesoderm || neural plate || head mesoderm || mesoderm || mesenchyme || ventral mesoderm || pre-chordal neural plate || head mesenchyme || neuroectoderm || involuted dorsal mesoderm || chordal neural plate
Kazal-type serine protease inhibitors	0.7218	INHERITED FROM: neural plate || hypochord || neural groove || notochord
Sema domain	0.7637	INHERITED FROM: cranial placode || neural crest || neuroectoderm || involuted dorsal mesoderm || cranial neural crest || otic placode
Protein kinase-like (PK-like)	0.773	INHERITED FROM: head mesoderm || regenerating hindlimb
Integrin domains	0.831	INHERITED FROM: mesodermal cell || fibroblast
EGF/Laminin	0.8315	INHERITED FROM: hypochord || neural groove || notochord
Tropomyosin	0.8591	INHERITED FROM: myotome || dermomyotome || myocyte || myocardium
PYP-like sensor domain (PAS domain)	0.9786	INHERITED FROM: somite || mesoderm || epaxial muscle
Plexin repeat	1	INHERITED FROM: cranial placode || neural crest || neuroectoderm || involuted dorsal mesoderm || cranial neural crest || otic placode
beta-beta-alpha zinc fingers	1	INHERITED FROM: pre-chordal neural plate border || anterior neural ridge || chordal neural plate border || neural fold || splanchnic layer of lateral plate mesoderm || pre-chordal neural plate || chordal neural plate
Family A G protein-coupled receptor-like	1	INHERITED FROM: granule cell layer of the olfactory bulb
Metalloproteases ("zincins"), catalytic domain	1	INHERITED FROM: notochordal sheath || mesodermal cell || fibroblast
Fibronectin type III	1	INHERITED FROM: retinal ganglion cell layer || retinal inner nuclear layer
EF-hand	1	INHERITED FROM: myocyte
TSP-1 type 1 repeat	1	INHERITED FROM: hypochord
Cadherin-like	1	INHERITED FROM: neural crest
Ras GEF	1	INHERITED FROM: retinal inner plexiform layer || retinal outer plexiform layer
Voltage-gated potassium channels	1	INHERITED FROM: retinal ganglion cell layer || retinal inner plexiform layer || cephalic nerve || optic nerve || nerve

Family domains annotated to this XA term (SDXA level: Least Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Choline/Carnitine O-acyltransferase	0	DIRECT
Troponin I	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
NTF2-like	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
Cryptochrome/photolyase, N-terminal domain	0	DIRECT
C-terminal domain of adenylylcyclase associated protein	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Class I aldolase	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
DNA polymerase III clamp loader subunits, C-terminal domain	0	DIRECT
SIAH, seven in absentia homolog	0	DIRECT
PAH2 domain	0	DIRECT
Phosphatidylethanolamine binding protein	0	DIRECT
SAP domain	0	DIRECT
TAFH domain-like	0	DIRECT
Cell cycle transcription factor e2f-dp	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Guanido kinase catalytic domain	0	DIRECT
TSP type-3 repeat	0	DIRECT
PDI-like	0	DIRECT
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain	0	DIRECT
Fibrinogen coiled-coil and central regions	0	DIRECT
Hedgehog (development protein), N-terminal signaling domain	0	DIRECT
Ran-binding domain	0	DIRECT
TRAPP components	0	DIRECT
MIR domain	0	DIRECT
Cofilin-like	0	DIRECT
CAT-like	0	DIRECT
Delta-sleep-inducing peptide immunoreactive peptide	0	DIRECT
Connexin43	0	DIRECT
MSP-like	0	DIRECT
Troponin T	0	DIRECT
Carboxylesterase	0	DIRECT
Malic enzyme N-domain	0	DIRECT
FF domain	0	DIRECT
HAT/Suf repeat	0	DIRECT
acyl-CoA oxidase C-terminal domains	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
alpha-catenin/vinculin	0	DIRECT
Kinase associated domain 1, KA1	0	DIRECT
DNA ligase/mRNA capping enzyme postcatalytic domain	0	DIRECT
ADP-ribosylglycohydrolase	0	DIRECT
Prefoldin	0	DIRECT
14-3-3 protein	0	DIRECT
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
Eukaryotic ODC-like	0	DIRECT
Cytochrome b5	0	DIRECT
Hairy Orange domain	0	DIRECT
Cryptochrome/photolyase FAD-binding domain	0	DIRECT
P4 origin-binding domain-like	0	DIRECT
BAG domain	0	DIRECT
Trefoil	0	DIRECT
Nop domain	0	DIRECT
DLC	0	DIRECT
Bromodomain	0	DIRECT
Extracellular domain of cell surface receptors	0	DIRECT
Pumilio repeat	0	DIRECT
Aminoacid dehydrogenase-like, C-terminal domain	0	DIRECT
Mib/herc2 domain	0	DIRECT
Histone deacetylase, HDAC	0	DIRECT
Phosphoribosylpyrophosphate synthetase-like	0	DIRECT
Heat-shock transcription factor	0	DIRECT
SMAD domain	0	DIRECT
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	0	DIRECT
Thrombospondin C-terminal domain	0	DIRECT
Ribonuclease PH domain 1-like	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase PP module	0	DIRECT
DNA ligase	0	DIRECT
Adenain-like	0	DIRECT
N-type ATP pyrophosphatases	0	DIRECT
HCDH C-domain-like	0	DIRECT
Aconitase iron-sulfur domain	0	DIRECT
Pointed domain	0	DIRECT
S-adenosylhomocystein hydrolase	0	DIRECT
IF2B-like	0	DIRECT
Proteasome activator	0	DIRECT
E2F dimerization segment	0	DIRECT
Alanine racemase-like, N-terminal domain	0	DIRECT
TRASH domain	0	DIRECT
Phenylalanine metabolism regulatory domain	0	DIRECT
Class I glutamine amidotransferases (GAT)	0	DIRECT
ECR1 N-terminal domain-like	0	DIRECT
Autophagin-like	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase Pyr module	0	DIRECT
Nucleoplasmin-like core domain	0	DIRECT
Alpha-adaptin ear subdomain-like	0	DIRECT
GABARAP-like	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
L domain	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Hsp90 middle domain	0	DIRECT
Domain G2 of nidogen-1	0	DIRECT
Ribosomal protein L3	0	DIRECT
Arrestin/Vps26-like	0	DIRECT
Pseudouridine synthase I TruA	0	DIRECT
N-acetylmuramoyl-L-alanine amidase-like	0	DIRECT
Notch domain	0	DIRECT
MIF4G domain-like	0	DIRECT
RUNT domain	0	DIRECT
Ribosomal proteins L15p and L18e	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
Fibroblast growth factors (FGF)	0	DIRECT
Arginase-like amidino hydrolases	0	DIRECT
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
Serine carboxypeptidase-like	0	DIRECT
Mitochondrial cytochrome c oxidase subunit VIIa	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Sedlin (SEDL)	0	DIRECT
Apolipoprotein A-I	0	DIRECT
Cytidylyltransferase	0	DIRECT
Clathrin adaptor appendage, alpha and beta chain-specific domain	0	DIRECT
Cystathionine synthase-like	0	DIRECT
ATP-dependent DNA ligase catalytic domain	0	DIRECT
gamma-adaptin C-terminal appendage domain-like	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
Paired domain	0	DIRECT
Synuclein	0	DIRECT
BRK domain-like	0	DIRECT
Ferritin	0	DIRECT
SRF-like	0	DIRECT
Complement components	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Tim10/DDP	0	DIRECT
ets domain	0	DIRECT
RNA-polymerase beta-prime	0	DIRECT
Prokaryotic proteases	0	DIRECT
NIPSNAP	0	DIRECT
Moesin tail domain	0	DIRECT
NAP-like	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
Noggin	0	DIRECT
alpha-ketoacid dehydrogenase kinase, C-terminal domain	0	DIRECT
B56-like	0	DIRECT
RNA-polymerase beta	0	DIRECT
Polo-box duplicated region	0	DIRECT
ZZ domain	0	DIRECT
FAS1 domain	0	DIRECT
BSD domain	0	DIRECT
Class II glutamine amidotransferases	0	DIRECT
A20-like zinc finger	0	DIRECT
acyl-CoA oxidase N-terminal domains	0	DIRECT
NagB-like	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
MHCK/EF2 kinase	0	DIRECT
Sm motif of small nuclear ribonucleoproteins, SNRNP	0	DIRECT
Trunk domain of Sec23/24	0	DIRECT
Cap-Gly domain	0	DIRECT
Myosin phosphatase inhibitor 17kDa protein, CPI-17	0	DIRECT
Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	0	DIRECT
MPP-like	0	DIRECT
Retinol binding protein-like	0	DIRECT
LON domain-like	0	DIRECT
HIT (HINT, histidine triad) family of protein kinase-interacting proteins	0	DIRECT
alpha-ketoacid dehydrogenase kinase, N-terminal domain	0	DIRECT
SMAD MH1 domain	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
UBX domain	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
LeuD-like	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Dimeric isocitrate & isopropylmalate dehydrogenases	0	DIRECT
NLI interacting factor-like phosphatase	0	DIRECT
Translation initiation factor eIF4e	0	DIRECT
IP3 receptor type 1 binding core, domain 2	0	DIRECT
GDI-like N domain	0	DIRECT
HD domain	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
Noncollagenous (NC1) domain of collagen IV	0	DIRECT
SH3BGR (SH3-binding, glutamic acid-rich protein-like)	0	DIRECT
Alpha-macroglobulin receptor domain	0	DIRECT
WGR domain	0	DIRECT
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains	0	DIRECT
DJ-1/PfpI	0	DIRECT
Canonical RBD	0.000000305	DIRECT
Homeodomain	0.0002637	DIRECT
UBC-related	0.0004594	DIRECT
HLH, helix-loop-helix DNA-binding domain	0.0006991	DIRECT
Cyclin	0.009923	INHERITED FROM: migratory neural crest cell || postmigratory neural crest cell
Actin/HSP70	0.01593	INHERITED FROM: head mesoderm || skeletal muscle || myocyte || head somite || jaw muscle || muscle || trunk somite || cranial muscle
Forkhead DNA-binding domain	0.01624	INHERITED FROM: neural plate || pre-chordal neural plate border || ciliated epidermal cell || anterior neural ridge || head mesoderm || mesoderm || tail tip || chordoneural hinge || preplacodal ectoderm || neural fold || vagal neural crest || anterior placodal area || mesenchyme || optic field || presomitic mesoderm || anterior neural fold || pronephric nephrostome || sensorial layer of neurectoderm || pre-chordal neural plate || epithelial cell || neural crest || involuted ventral mesoderm || neuroectoderm || involuted dorsal mesoderm || myocardium || tail fin
Histone lysine methyltransferases	0.02852	INHERITED FROM: primary germ layer
Proteasome subunits	0.02852	INHERITED FROM: skeletal muscle || muscle
Tandem AAA-ATPase domain	0.03862	INHERITED FROM: ventral blood island || otic vesicle
LIM domain	0.04299	INHERITED FROM: cranial placode
T-box	0.04781	INHERITED FROM: mesoderm || mesenchyme || neurogenic placode || involuted ventral mesoderm || involuted dorsal mesoderm || myocardium || regenerating tissue || blastema || notochord || primary heart field
Glutathione peroxidase-like	0.0521	INHERITED FROM: proximal tubule || early distal tubule || pronephric tubule || pronephric mesenchyme || presomitic mesoderm || early proximal tubule || presumptive paraxial mesoderm || bone tissue || distal tubule || cranial neural crest || skeletal tissue || paraxial mesoderm
PHD domain	0.06342	INHERITED FROM: primary germ layer
HMG-box	0.07126	INHERITED FROM: mandibular crest || neural plate || neuroectoderm outer layer || endocardium || posterior branchial crest || midbrain-hindbrain boundary || neural fold || hyoid crest || retinal layer || blastocoel floor || endoderm || optic field || anterior neural fold || pre-chordal neural plate || anterior branchial crest || neurogenic placode || neuroectoderm || neural plate border || cranial neural crest || otic vesicle
Transforming growth factor (TGF)-beta	0.07301	INHERITED FROM: secondary heart field || head mesoderm || vegetal endoderm || mesoderm || early distal tubule || gastrocoel roof plate || mesenchyme || mouth primordium || endoderm || ventral mesoderm || head mesenchyme || neurogenic placode || involuted dorsal mesoderm || regenerating tissue || blastema || notochord || primary heart field || involuting marginal zone mesenchymal layer
Heat shock protein 70kD (HSP70), peptide-binding domain	0.101	INHERITED FROM: skeletal muscle
ARID domain	0.101	INHERITED FROM: pronephric tubule
Growth factor receptor domain	0.1265	INHERITED FROM: fin || hypochord || mesoderm || mesenchyme || notochord
Tubulin, GTPase domain	0.1445	INHERITED FROM: trigeminal nerve || vagus nerve || epidermis || gastrocoel roof plate || glossopharyngeal nerve || facial nerve || epithelium || epithelial cell || epidermal cell || non-neural ectoderm
Tubulin, C-terminal domain	0.1445	INHERITED FROM: trigeminal nerve || vagus nerve || epidermis || gastrocoel roof plate || glossopharyngeal nerve || facial nerve || epithelium || epithelial cell || epidermal cell || non-neural ectoderm
Small Kunitz-type inhibitors & BPTI-like toxins	0.1579	INHERITED FROM: adipose tissue
Thiolase-related	0.2059	INHERITED FROM: skeletal muscle || muscle
Group II chaperonin (CCT, TRIC), apical domain	0.2059	INHERITED FROM: anterior dorsal lateral plate region || skeletal muscle || muscle
Translational machinery components	0.2059	INHERITED FROM: skeletal muscle || muscle
Group II chaperonin (CCT, TRIC), ATPase domain	0.207	INHERITED FROM: skeletal muscle || muscle
Myosin rod fragments	0.2108	INHERITED FROM: musculature of face
Transducin (alpha subunit), insertion domain	0.2435	INHERITED FROM: olfactory epithelium || olfactory sensory neuron
POU-specific domain	0.2435	INHERITED FROM: retinal ganglion cell layer || neural plate || proximal tubule || early distal tubule || neural fold || pronephric tubule || pronephric mesenchyme || pre-chordal neural plate || neurogenic placode || neuroectoderm || distal tubule || late distal tubule || chordal neural plate
Erythroid transcription factor GATA-1	0.2575	INHERITED FROM: lateral plate mesoderm || mesoderm || anterior dorsal lateral plate region || endoderm || ventral blood island || hematopoietic stem cell || archenteron floor || myocardium || archenteron
Ovomucoid domain III-like	0.2673	INHERITED FROM: neural plate || hypochord || neural groove || notochord
Second domain of FERM	0.2718	INHERITED FROM: trigeminal nerve
Hemopexin-like domain	0.3138	INHERITED FROM: mesodermal cell || fibroblast || notochord
Parvalbumin	0.3221	INHERITED FROM: somite || cranial muscle
Cell cycle control phosphatase, catalytic domain	0.3221	INHERITED FROM: neural plate || neuroectoderm || chordal neural plate
Higher-molecular-weight phosphotyrosine protein phosphatases	0.3271	INHERITED FROM: retinal ganglion cell layer || retinal inner nuclear layer
I set domains	0.3395	INHERITED FROM: retinal ganglion cell layer || retinal inner nuclear layer || pharyngeal mesenchyme || wound epidermis || regenerating hindlimb
VWC domain	0.3436	INHERITED FROM: hypochord || mesoderm || mesenchyme || endoderm || notochord
Spectrin repeat	0.3733	INHERITED FROM: auditory hair cell || sensory epithelial cell || epithelial cell
Frizzled cysteine-rich domain	0.3733	INHERITED FROM: somite || lateral plate mesoderm || neural plate || mesoderm || tail tip || midbrain-hindbrain boundary || neural fold || mesenchyme || mouth primordium || endoderm || optic field || presomitic mesoderm || anterior neural fold || pre-chordal neural plate || presumptive paraxial mesoderm || stomodeal-hypophyseal primordium || neuroectoderm || involuted dorsal mesoderm || otic vesicle || tail fin
Linker histone H1/H5	0.399	INHERITED FROM: connective tissue || bone tissue || skeletal tissue
Lactate & malate dehydrogenases, C-terminal domain	0.399	INHERITED FROM: connective tissue || bone tissue || skeletal tissue
LDH N-terminal domain-like	0.399	INHERITED FROM: connective tissue || bone tissue || skeletal tissue
Matrix metalloproteases, catalytic domain	0.4134	INHERITED FROM: notochordal sheath || mesodermal cell || fibroblast || notochord
Intermediate filament protein, coiled coil region	0.4446	INHERITED FROM: retinal ganglion cell layer || retinal inner plexiform layer || retinal inner nuclear layer || retinal ganglion cell || cephalic nerve || ganglion || epidermis || vestibulocochlear nerve || spinal ganglion || optic nerve || epithelium || regenerating tissue || blastema || nerve
MMP N-terminal domain	0.4736	INHERITED FROM: notochordal sheath || notochord
Sema domain	0.5392	INHERITED FROM: neural plate || midbrain-hindbrain boundary || cranial placode || neural crest || neuroectoderm || involuted dorsal mesoderm || cranial neural crest || otic placode
G proteins	0.5643	INHERITED FROM: olfactory epithelium || olfactory sensory neuron
Fibronectin type II module	0.6306	INHERITED FROM: mesenchyme || epithelium
Globins	0.6382	INHERITED FROM: anterior dorsal lateral plate region || ventral blood island || hematopoietic stem cell || anterior ventral blood island
Kringle modules	0.6664	INHERITED FROM: neural groove
Tropomyosin	0.7011	INHERITED FROM: myotome || dermomyotome || myocyte || myocardium || multilaminar epithelium
Ephrin ectodomain	0.7201	INHERITED FROM: sensorial layer of neurectoderm
Multidrug efflux transporter AcrB transmembrane domain	0.7201	INHERITED FROM: epidermis
Arginine methyltransferase	0.7201	INHERITED FROM: cranial neural crest
Hypoxia-inducible factor Hif2a, C-terminal domain	0.8233	INHERITED FROM: somite || mesoderm || epaxial muscle || pronephric tubule || otic vesicle
Integrin domains	0.8385	INHERITED FROM: mesodermal cell || fibroblast
Ephrin receptor ligand binding domain	0.8521	INHERITED FROM: branchial crest
28-residue LRR	0.8798	INHERITED FROM: epaxial muscle
Proprotein convertase P-domain	0.9202	INHERITED FROM: notochord
Motor proteins	0.9556	INHERITED FROM: musculature of face
Protein kinases, catalytic subunit	0.9897	INHERITED FROM: head mesoderm || regenerating hindlimb
Fibronectin type III	1	INHERITED FROM: retinal ganglion cell layer
Calmodulin-like	1	INHERITED FROM: ciliated epidermal cell || epithelial cell
TSP-1 type 1 repeat	1	INHERITED FROM: hypochord
Classic zinc finger, C2H2	1	INHERITED FROM: pre-chordal neural plate border || anterior neural ridge || chordal neural plate border || neural fold || splanchnic layer of lateral plate mesoderm || anterior neural fold || pre-chordal neural plate || neural plate border || chordal neural plate
Voltage-gated potassium channels	1	INHERITED FROM: retinal inner plexiform layer || optic nerve
Plexin repeat	1	INHERITED FROM: cranial placode || neural crest || neuroectoderm || cranial neural crest || otic placode
Rhodopsin-like	1	INHERITED FROM: eye photoreceptor cell || granule cell layer of the olfactory bulb
Tetramerization domain of potassium channels	1	INHERITED FROM: retinal ganglion cell layer || retinal inner plexiform layer || optic nerve || retinal outer plexiform layer