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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

• Disease Ontology (DO) Ontology (DO)
  DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
  
• Human Phenotype (HP) Ontology (HP)
  HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
  
• Mouse Phenotype (MP) Ontology (MP)
  MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
  
• Worm Phenotype (WP) Ontology (WP)
  WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
  
• Yeast Phenotype (YP) Ontology (YP)
  Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
  
• Fly Phenotype (FP) Ontology (FP)
  FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
  
• Fly Anatomy (FA) Ontology (FA)
  FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
  
• Zebrafish Anatomy (ZA) Ontology (ZA)
  ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
  
• Xenopus Anatomy (XA) Ontology (XA)
  XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
  
• Arabidopsis Plant Ontology (AP) Ontology (AP)
  As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
  
• Enzyme Commission (EC) Ontology (EC)
  Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
  
• DrugBank ATC (DB) Ontology (DB)
  In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
  
• UniProtKB KeyWords (KW) Ontology (KW)
  Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
  
• UniProtKB UniPathway (UP) Ontology (UP)
  UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
  

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
  

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
  

Superfamily domains annotated to this XA term (SDXA level: Least Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
KA1-like	0	DIRECT
Synuclein	0	DIRECT
DLC	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
Mitochondrial cytochrome c oxidase subunit VIIa	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
PEBP-like	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
Mediator hinge subcomplex-like	0	DIRECT
PAP/OAS1 substrate-binding domain	0	DIRECT
Acyl-CoA dehydrogenase C-terminal domain-like	0	DIRECT
MIR domain	0	DIRECT
TK C-terminal domain-like	0	DIRECT
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Notch domain	0	DIRECT
Sec63 N-terminal domain-like	0	DIRECT
Alanine racemase C-terminal domain-like	0	DIRECT
Fibrinogen coiled-coil and central regions	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
PAH2 domain	0	DIRECT
TSP type-3 repeat	0	DIRECT
BAG domain	0	DIRECT
SPOC domain-like	0	DIRECT
Zn-binding ribosomal proteins	0	DIRECT
ADP-ribosylglycohydrolase	0	DIRECT
LuxS/MPP-like metallohydrolase	0	DIRECT
Ribulose-phoshate binding barrel	0	DIRECT
Uracil-DNA glycosylase-like	0	DIRECT
Orange domain-like	0	DIRECT
Connexin43	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
G protein-binding domain	0	DIRECT
FMT C-terminal domain-like	0	DIRECT
Nop domain	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Subunits of heterodimeric actin filament capping protein Capz	0	DIRECT
Soluble quinoprotein glucose dehydrogenase	0	DIRECT
Delta-sleep-inducing peptide immunoreactive peptide	0	DIRECT
C-terminal domain of adenylylcyclase associated protein	0	DIRECT
HRDC-like	0	DIRECT
IP3 receptor type 1 binding core, domain 2	0	DIRECT
Ribosomal L27 protein-like	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
Class I glutamine amidotransferase-like	0	DIRECT
SRF-like	0	DIRECT
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	0	DIRECT
Nucleoporin domain	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
Cryptochrome/photolyase, N-terminal domain	0	DIRECT
Aconitase iron-sulfur domain	0	DIRECT
Apolipoprotein A-I	0	DIRECT
Isocitrate/Isopropylmalate dehydrogenase-like	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
Ferritin-like	0	DIRECT
Nucleoplasmin-like core domain	0	DIRECT
SMAD MH1 domain	0	DIRECT
DNA ligase/mRNA capping enzyme, catalytic domain	0	DIRECT
Cryptochrome/photolyase FAD-binding domain	0	DIRECT
GYF domain	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
Myosin phosphatase inhibitor 17kDa protein, CPI-17	0	DIRECT
SAP domain	0	DIRECT
SIS domain	0	DIRECT
Bromodomain	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Cap-Gly domain	0	DIRECT
Troponin coil-coiled subunits	0	DIRECT
Proteasome activator	0	DIRECT
FF domain	0	DIRECT
post-AAA+ oligomerization domain-like	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
ATP-dependent DNA ligase DNA-binding domain	0	DIRECT
Endosomal sorting complex assembly domain	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
Moesin tail domain	0	DIRECT
NAP-like	0	DIRECT
TAFH domain-like	0	DIRECT
WGR domain-like	0	DIRECT
Alpha-macroglobulin receptor domain	0	DIRECT
N-acetylmuramoyl-L-alanine amidase-like	0	DIRECT
4Fe-4S ferredoxins	0	DIRECT
Acyl-CoA dehydrogenase NM domain-like	0	DIRECT
Ribosomal proteins S24e, L23 and L15e	0	DIRECT
Trefoil	0	DIRECT
CoA-dependent acyltransferases	0	DIRECT
L-aspartase-like	0	DIRECT
Mib/herc2 domain-like	0	DIRECT
FAS1 domain	0	DIRECT
Tim10-like	0	DIRECT
BRK domain-like	0	DIRECT
PLP-binding barrel	0	DIRECT
alpha-ketoacid dehydrogenase kinase, N-terminal domain	0	DIRECT
Aminoacid dehydrogenase-like, N-terminal domain	0	DIRECT
Clathrin adaptor appendage domain	0	DIRECT
LeuD/IlvD-like	0	DIRECT
Hedgehog/DD-peptidase	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
NTF2-like	0	DIRECT
Subdomain of clathrin and coatomer appendage domain	0	DIRECT
14-3-3 protein	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
Translation proteins SH3-like domain	0	DIRECT
Di-copper centre-containing domain	0	DIRECT
E2F-DP heterodimerization region	0	DIRECT
PriA/YqbF domain	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
BSD domain-like	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
alpha-catenin/vinculin-like	0	DIRECT
Ribosomal proteins L15p and L18e	0	DIRECT
GINS helical bundle-like	0	DIRECT
Arginase/deacetylase	0	DIRECT
Cytokine	0	DIRECT
eIF4e-like	0	DIRECT
GFP-like	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
Homeodomain-like	0.000005752	DIRECT
RNA-binding domain, RBD	0.00001458	DIRECT
"Winged helix" DNA-binding domain	0.0000676	DIRECT
Nucleic acid-binding proteins	0.0003338	DIRECT
HLH, helix-loop-helix DNA-binding domain	0.0004806	DIRECT
Thioredoxin-like	0.01133	INHERITED FROM: bone tissue || skeletal tissue || connective tissue || early proximal tubule
Cyclin-like	0.02063	INHERITED FROM: postmigratory neural crest cell
SET domain	0.03848	INHERITED FROM: primary germ layer
Actin depolymerizing proteins	0.05371	INHERITED FROM: bone tissue || skeletal tissue || connective tissue
HSP20-like chaperones	0.05852	INHERITED FROM: skeletal muscle
HMG-box	0.06078	INHERITED FROM: retinal layer || neural plate || neurogenic placode || anterior branchial crest || neural fold || anterior neural fold || posterior branchial crest || midbrain-hindbrain boundary || pre-chordal neural plate || cranial neural crest || chordal neural plate || endoderm || neuroectoderm outer layer || blastocoel floor || hyoid crest || endocardium || otic vesicle || neuroectoderm || mandibular crest || neural plate border || optic field || neural crest
Tubulin C-terminal domain-like	0.08989	INHERITED FROM: gastrocoel roof plate || epithelium || facial nerve || non-neural ectoderm || trigeminal nerve || vagus nerve || epidermis || epidermal cell || glossopharyngeal nerve || epithelial cell
ARID-like	0.1016	INHERITED FROM: pronephric tubule
Heat shock protein 70kD (HSP70), peptide-binding domain	0.1016	INHERITED FROM: skeletal muscle
GroEL equatorial domain-like	0.122	INHERITED FROM: skeletal muscle || anterior dorsal lateral plate region || endomesoderm || muscle
Actin-like ATPase domain	0.126	INHERITED FROM: cranial muscle || skeletal muscle || myocyte || head somite || jaw muscle
p53-like transcription factors	0.1328	INHERITED FROM: primary heart field || involuted ventral mesoderm || neural plate || notochord || neurogenic placode || mesenchyme || cartilage tissue || cranial placode || regenerating tissue || blastema || myocardium || neuroectoderm || mesoderm
GroEL-intermediate domain like	0.164	INHERITED FROM: skeletal muscle || anterior dorsal lateral plate region || endomesoderm || muscle
Second domain of FERM	0.1939	INHERITED FROM: nerve
Tubulin nucleotide-binding domain-like	0.2064	INHERITED FROM: gastrocoel roof plate || epithelium || facial nerve || non-neural ectoderm || trigeminal nerve || vagus nerve || epidermis || epidermal cell || glossopharyngeal nerve || epithelial cell
Glucocorticoid receptor-like (DNA-binding domain)	0.2216	INHERITED FROM: sensorial layer of neurectoderm || post-anal gut || zona limitans intrathalamica || cranial placode || proximal tubule branch || preplacodal ectoderm || archenteron floor || neuroectoderm || anterior placodal area
Transducin (alpha subunit), insertion domain	0.2389	INHERITED FROM: olfactory epithelium || olfactory sensory neuron
Spectrin repeat	0.2389	INHERITED FROM: sensory epithelial cell || auditory hair cell || epithelial cell
Translation proteins	0.2389	INHERITED FROM: ventral blood island
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.263	INHERITED FROM: skeletal muscle
Hemopexin-like domain	0.2986	INHERITED FROM: notochord || mesodermal cell || fibroblast
GroEL apical domain-like	0.3224	INHERITED FROM: skeletal muscle || anterior dorsal lateral plate region || muscle
Myosin rod fragments	0.3462	INHERITED FROM: musculature of face
Frizzled cysteine-rich domain	0.357	INHERITED FROM: neural plate || neurogenic placode || mesenchyme || presumptive paraxial mesoderm || neural fold || anterior neural fold || lateral plate mesoderm || somite || midbrain-hindbrain boundary || mouth primordium || pre-chordal neural plate || involuted dorsal mesoderm || tail tip || presomitic mesoderm || endoderm || stomodeal-hypophyseal primordium || otic vesicle || neuroectoderm || tail fin || mesoderm || optic field
Clavaminate synthase-like	0.3741	INHERITED FROM: late distal tubule || late proximal tubule
Phosphoglycerate mutase-like	0.3794	INHERITED FROM: head mesenchyme || notochord || mesenchyme
SMAD/FHA domain	0.3855	INHERITED FROM: endocardium
Annexin	0.3993	INHERITED FROM: bone tissue
LDH C-terminal domain-like	0.4047	INHERITED FROM: bone tissue || skeletal tissue || connective tissue
Cystine-knot cytokines	0.4712	INHERITED FROM: primary heart field || head mesenchyme || neural groove || notochord || neurogenic placode || mesenchyme || mouth primordium || involuted dorsal mesoderm || regenerating tissue || blastema || endoderm || head mesoderm || involuting marginal zone mesenchymal layer || vegetal endoderm || ventral mesoderm || neuroectoderm || secondary heart field || mesoderm
Thiolase-like	0.4714	INHERITED FROM: skeletal muscle
lambda repressor-like DNA-binding domains	0.5063	INHERITED FROM: neural plate || pronephric tubule || neurogenic placode || neural fold || pronephric mesenchyme || cranial placode || early distal tubule || proximal tubule || chordal neural plate || distal tubule || late distal tubule || neuroectoderm
Kringle-like	0.5667	INHERITED FROM: epithelium || neural groove
FnI-like domain	0.5755	INHERITED FROM: notochord || hypochord || somite || endoderm || epithelial cell
Intermediate filament protein, coiled coil region	0.6137	INHERITED FROM: epithelium || nerve || ganglion || vestibulocochlear nerve || retinal ganglion cell || cranial nerve || retinal inner nuclear layer || retinal inner plexiform layer || optic nerve || epidermis || retinal ganglion cell layer || spinal ganglion
Globin-like	0.6352	INHERITED FROM: anterior ventral blood island || anterior dorsal lateral plate region || ventral blood island
Growth factor receptor domain	0.6513	INHERITED FROM: notochord || hypochord || mesenchyme || tail tip || anterior neural ridge || fin || pre-chordal neural plate border || otic vesicle
TIMP-like	0.6928	INHERITED FROM: pre-chordal neural plate || endoderm || stomodeal-hypophyseal primordium || optic field
Snake toxin-like	0.696	INHERITED FROM: neural plate || head mesenchyme || dorsal lateral plate mesoderm || mesenchyme || lateral plate mesoderm || pre-chordal neural plate || involuted dorsal mesoderm || chordal neural plate || head mesoderm || ventral mesoderm || neuroectoderm || mesoderm
Kazal-type serine protease inhibitors	0.7193	INHERITED FROM: neural plate || neural groove || notochord || hypochord
Tropomyosin	0.7544	INHERITED FROM: myotome || dermomyotome || myocyte || myocardium
Sema domain	0.7626	INHERITED FROM: cranial placode || involuted dorsal mesoderm || cranial neural crest || otic placode || neuroectoderm || neural crest
Protein kinase-like (PK-like)	0.7803	INHERITED FROM: head mesoderm || regenerating hindlimb
Integrin domains	0.8282	INHERITED FROM: mesodermal cell || fibroblast
EGF/Laminin	0.8949	INHERITED FROM: neural groove || notochord || hypochord
PYP-like sensor domain (PAS domain)	0.9747	INHERITED FROM: somite || epaxial muscle
Voltage-gated potassium channels	1	INHERITED FROM: nerve || cranial nerve || retinal inner plexiform layer || optic nerve || retinal ganglion cell layer
beta-beta-alpha zinc fingers	1	INHERITED FROM: chordal neural plate border || neural fold || pre-chordal neural plate || anterior neural ridge || chordal neural plate || pre-chordal neural plate border || splanchnic layer of lateral plate mesoderm
Family A G protein-coupled receptor-like	1	INHERITED FROM: granule cell layer of the olfactory bulb
EF-hand	1	INHERITED FROM: myocyte
TSP-1 type 1 repeat	1	INHERITED FROM: hypochord
Metalloproteases ("zincins"), catalytic domain	1	INHERITED FROM: mesodermal cell || fibroblast
Fibronectin type III	1	INHERITED FROM: retinal inner nuclear layer || retinal ganglion cell layer
Plexin repeat	1	INHERITED FROM: cranial placode || involuted dorsal mesoderm || cranial neural crest || otic placode || neuroectoderm || neural crest

Family domains annotated to this XA term (SDXA level: Least Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
acyl-CoA oxidase C-terminal domains	0	DIRECT
Moesin tail domain	0	DIRECT
Cystathionine synthase-like	0	DIRECT
Histone deacetylase, HDAC	0	DIRECT
ZZ domain	0	DIRECT
Ferritin	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Malic enzyme N-domain	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
NAP-like	0	DIRECT
Translation initiation factor eIF4e	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
Dimeric isocitrate & isopropylmalate dehydrogenases	0	DIRECT
CAT-like	0	DIRECT
Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Hairy Orange domain	0	DIRECT
HCDH C-domain-like	0	DIRECT
Extracellular domain of cell surface receptors	0	DIRECT
Notch domain	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase Pyr module	0	DIRECT
PAH2 domain	0	DIRECT
Noncollagenous (NC1) domain of collagen IV	0	DIRECT
Cryptochrome/photolyase FAD-binding domain	0	DIRECT
HIT (HINT, histidine triad) family of protein kinase-interacting proteins	0	DIRECT
Myosin phosphatase inhibitor 17kDa protein, CPI-17	0	DIRECT
Troponin I	0	DIRECT
P4 origin-binding domain-like	0	DIRECT
TAFH domain-like	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
SRF-like	0	DIRECT
Paired domain	0	DIRECT
SH3BGR (SH3-binding, glutamic acid-rich protein-like)	0	DIRECT
Bromodomain	0	DIRECT
Pseudouridine synthase I TruA	0	DIRECT
DNA ligase/mRNA capping enzyme postcatalytic domain	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
Phenylalanine metabolism regulatory domain	0	DIRECT
DLC	0	DIRECT
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain	0	DIRECT
NagB-like	0	DIRECT
NTF2-like	0	DIRECT
HAT/Suf repeat	0	DIRECT
E2F dimerization segment	0	DIRECT
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	0	DIRECT
Phosphatidylethanolamine binding protein	0	DIRECT
S-adenosylhomocystein hydrolase	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
Prefoldin	0	DIRECT
Hsp90 middle domain	0	DIRECT
FF domain	0	DIRECT
Serine carboxypeptidase-like	0	DIRECT
Aminoacid dehydrogenase-like, C-terminal domain	0	DIRECT
Arginase-like amidino hydrolases	0	DIRECT
SMAD domain	0	DIRECT
Cryptochrome/photolyase, N-terminal domain	0	DIRECT
Proteasome activator	0	DIRECT
L domain	0	DIRECT
PDI-like	0	DIRECT
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain	0	DIRECT
Troponin T	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
Class I aldolase	0	DIRECT
alpha-ketoacid dehydrogenase kinase, N-terminal domain	0	DIRECT
14-3-3 protein	0	DIRECT
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain	0	DIRECT
SMAD MH1 domain	0	DIRECT
Trefoil	0	DIRECT
Nucleoplasmin-like core domain	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
BSD domain	0	DIRECT
Heat-shock transcription factor	0	DIRECT
GDI-like N domain	0	DIRECT
Alanine racemase-like, N-terminal domain	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Eukaryotic ODC-like	0	DIRECT
B56-like	0	DIRECT
Retinol binding protein-like	0	DIRECT
Arrestin/Vps26-like	0	DIRECT
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains	0	DIRECT
HD domain	0	DIRECT
Complement components	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
MIR domain	0	DIRECT
LeuD-like	0	DIRECT
Delta-sleep-inducing peptide immunoreactive peptide	0	DIRECT
Fibroblast growth factors (FGF)	0	DIRECT
NLI interacting factor-like phosphatase	0	DIRECT
Guanido kinase catalytic domain	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase PP module	0	DIRECT
Cofilin-like	0	DIRECT
Ribonuclease PH domain 1-like	0	DIRECT
UBX domain	0	DIRECT
ATP-dependent DNA ligase catalytic domain	0	DIRECT
Tim10/DDP	0	DIRECT
ets domain	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
RNA-polymerase beta-prime	0	DIRECT
Autophagin-like	0	DIRECT
NIPSNAP	0	DIRECT
Domain G2 of nidogen-1	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
alpha-catenin/vinculin	0	DIRECT
Carboxylesterase	0	DIRECT
TRAPP components	0	DIRECT
MSP-like	0	DIRECT
Sm motif of small nuclear ribonucleoproteins, SNRNP	0	DIRECT
Hedgehog (development protein), N-terminal signaling domain	0	DIRECT
WGR domain	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	0	DIRECT
Nop domain	0	DIRECT
Class II glutamine amidotransferases	0	DIRECT
Ran-binding domain	0	DIRECT
BRK domain-like	0	DIRECT
ADP-ribosylglycohydrolase	0	DIRECT
C-terminal domain of adenylylcyclase associated protein	0	DIRECT
Clathrin adaptor appendage, alpha and beta chain-specific domain	0	DIRECT
Kinase associated domain 1, KA1	0	DIRECT
ECR1 N-terminal domain-like	0	DIRECT
Trunk domain of Sec23/24	0	DIRECT
Apolipoprotein A-I	0	DIRECT
Cytidylyltransferase	0	DIRECT
MHCK/EF2 kinase	0	DIRECT
acyl-CoA oxidase N-terminal domains	0	DIRECT
N-acetylmuramoyl-L-alanine amidase-like	0	DIRECT
LON domain-like	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
RNA-polymerase beta	0	DIRECT
gamma-adaptin C-terminal appendage domain-like	0	DIRECT
Ribosomal proteins L15p and L18e	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
Aconitase iron-sulfur domain	0	DIRECT
Noggin	0	DIRECT
Cell cycle transcription factor e2f-dp	0	DIRECT
Pointed domain	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
DJ-1/PfpI	0	DIRECT
Fibrinogen coiled-coil and central regions	0	DIRECT
Polo-box duplicated region	0	DIRECT
TSP type-3 repeat	0	DIRECT
DNA polymerase III clamp loader subunits, C-terminal domain	0	DIRECT
MPP-like	0	DIRECT
FAS1 domain	0	DIRECT
Mib/herc2 domain	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain	0	DIRECT
Choline/Carnitine O-acyltransferase	0	DIRECT
SAP domain	0	DIRECT
SIAH, seven in absentia homolog	0	DIRECT
Adenain-like	0	DIRECT
Ribosomal protein L3	0	DIRECT
TRASH domain	0	DIRECT
Sedlin (SEDL)	0	DIRECT
BAG domain	0	DIRECT
Connexin43	0	DIRECT
Alpha-macroglobulin receptor domain	0	DIRECT
Cytochrome b5	0	DIRECT
MIF4G domain-like	0	DIRECT
Prokaryotic proteases	0	DIRECT
DNA ligase	0	DIRECT
Pumilio repeat	0	DIRECT
alpha-ketoacid dehydrogenase kinase, C-terminal domain	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
IF2B-like	0	DIRECT
GABARAP-like	0	DIRECT
Phosphoribosylpyrophosphate synthetase-like	0	DIRECT
IP3 receptor type 1 binding core, domain 2	0	DIRECT
Class I glutamine amidotransferases (GAT)	0	DIRECT
Mitochondrial cytochrome c oxidase subunit VIIa	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
Thrombospondin C-terminal domain	0	DIRECT
Alpha-adaptin ear subdomain-like	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Synuclein	0	DIRECT
N-type ATP pyrophosphatases	0	DIRECT
Cap-Gly domain	0	DIRECT
RUNT domain	0	DIRECT
Canonical RBD	0.000001447	DIRECT
Homeodomain	0.0001483	DIRECT
UBC-related	0.0004616	DIRECT
HLH, helix-loop-helix DNA-binding domain	0.0008563	DIRECT
Cyclin	0.007788	INHERITED FROM: migratory neural crest cell || postmigratory neural crest cell
Actin/HSP70	0.01591	INHERITED FROM: tail somite || cranial muscle || skeletal muscle || trunk somite || muscle || myocyte || head mesoderm || head somite || jaw muscle
Forkhead DNA-binding domain	0.01624	INHERITED FROM: vagal neural crest || involuted ventral mesoderm || neural plate || sensorial layer of neurectoderm || mesenchyme || neural fold || anterior neural fold || pronephric nephrostome || chordoneural hinge || pre-chordal neural plate || involuted dorsal mesoderm || tail tip || anterior neural ridge || presomitic mesoderm || head mesoderm || pre-chordal neural plate border || preplacodal ectoderm || epithelial cell || ciliated epidermal cell || myocardium || neuroectoderm || tail fin || mesoderm || optic field || anterior placodal area || neural crest
Proteasome subunits	0.02844	INHERITED FROM: skeletal muscle || muscle
Histone lysine methyltransferases	0.02844	INHERITED FROM: primary germ layer
Tandem AAA-ATPase domain	0.03855	INHERITED FROM: ventral blood island || otic vesicle
LIM domain	0.04297	INHERITED FROM: cranial placode
T-box	0.04779	INHERITED FROM: primary heart field || involuted ventral mesoderm || notochord || neurogenic placode || mesenchyme || involuted dorsal mesoderm || regenerating tissue || blastema || myocardium || mesoderm
Glutathione peroxidase-like	0.05203	INHERITED FROM: bone tissue || pronephric tubule || skeletal tissue || presumptive paraxial mesoderm || pronephric mesenchyme || paraxial mesoderm || early distal tubule || cranial neural crest || proximal tubule || presomitic mesoderm || distal tubule || early proximal tubule
HMG-box	0.07074	INHERITED FROM: retinal layer || neural plate || anterior branchial crest || neural fold || anterior neural fold || posterior branchial crest || midbrain-hindbrain boundary || pre-chordal neural plate || cranial neural crest || epibranchial placode || endoderm || neuroectoderm outer layer || blastocoel floor || hyoid crest || endocardium || otic vesicle || neuroectoderm || mandibular crest || neural plate border || optic field || neural crest
Transforming growth factor (TGF)-beta	0.08629	INHERITED FROM: gastrocoel roof plate || primary heart field || head mesenchyme || neural groove || notochord || neurogenic placode || mesenchyme || mouth primordium || involuted dorsal mesoderm || early distal tubule || regenerating tissue || foregut endoderm || blastema || endoderm || head mesoderm || involuting marginal zone mesenchymal layer || vegetal endoderm || ventral mesoderm || secondary heart field || mesoderm
Tubulin, C-terminal domain	0.09305	INHERITED FROM: gastrocoel roof plate || epithelium || facial nerve || non-neural ectoderm || trigeminal nerve || vagus nerve || epidermis || epidermal cell || glossopharyngeal nerve || epithelial cell
Tubulin, GTPase domain	0.09305	INHERITED FROM: gastrocoel roof plate || epithelium || facial nerve || non-neural ectoderm || trigeminal nerve || vagus nerve || epidermis || epidermal cell || glossopharyngeal nerve || epithelial cell
Heat shock protein 70kD (HSP70), peptide-binding domain	0.1003	INHERITED FROM: skeletal muscle
ARID domain	0.1003	INHERITED FROM: pronephric tubule
Growth factor receptor domain	0.1254	INHERITED FROM: notochord || hypochord || mesenchyme || fin || mesoderm
Small Kunitz-type inhibitors & BPTI-like toxins	0.1566	INHERITED FROM: adipose tissue
Thiolase-related	0.2041	INHERITED FROM: skeletal muscle || muscle
Group II chaperonin (CCT, TRIC), apical domain	0.2041	INHERITED FROM: skeletal muscle || lateral plate mesoderm || anterior dorsal lateral plate region || muscle
Translational machinery components	0.2041	INHERITED FROM: skeletal muscle || muscle
Group II chaperonin (CCT, TRIC), ATPase domain	0.2048	INHERITED FROM: skeletal muscle || anterior dorsal lateral plate region || muscle
Myosin rod fragments	0.2088	INHERITED FROM: musculature of face
POU-specific domain	0.2406	INHERITED FROM: neural plate || pronephric tubule || neurogenic placode || neural fold || pronephric mesenchyme || pre-chordal neural plate || early distal tubule || proximal tubule || chordal neural plate || distal tubule || retinal ganglion cell layer || late distal tubule || neuroectoderm
Transducin (alpha subunit), insertion domain	0.2406	INHERITED FROM: olfactory epithelium || olfactory sensory neuron
Erythroid transcription factor GATA-1	0.2547	INHERITED FROM: lateral plate mesoderm || anterior dorsal lateral plate region || ventral blood island || endoderm || hematopoietic stem cell || archenteron floor || myocardium || mesoderm || archenteron
Ovomucoid domain III-like	0.2645	INHERITED FROM: neural plate || neural groove || notochord || hypochord
Second domain of FERM	0.2692	INHERITED FROM: trigeminal nerve
Hemopexin-like domain	0.3112	INHERITED FROM: notochord || mesodermal cell || fibroblast
Parvalbumin	0.3196	INHERITED FROM: cranial muscle || somite
Cell cycle control phosphatase, catalytic domain	0.3196	INHERITED FROM: neural plate || chordal neural plate || neuroectoderm
Higher-molecular-weight phosphotyrosine protein phosphatases	0.326	INHERITED FROM: retinal inner nuclear layer || retinal ganglion cell layer
I set domains	0.3369	INHERITED FROM: pharyngeal mesenchyme || wound epidermis || retinal inner nuclear layer || retinal ganglion cell layer || regenerating hindlimb
VWC domain	0.3407	INHERITED FROM: notochord || hypochord || mesenchyme || endoderm || mesoderm
Spectrin repeat	0.3704	INHERITED FROM: sensory epithelial cell || auditory hair cell || epithelial cell
Frizzled cysteine-rich domain	0.3704	INHERITED FROM: neural plate || neurogenic placode || mesenchyme || presumptive paraxial mesoderm || neural fold || anterior neural fold || lateral plate mesoderm || somite || midbrain-hindbrain boundary || mouth primordium || pre-chordal neural plate || involuted dorsal mesoderm || tail tip || presomitic mesoderm || endoderm || stomodeal-hypophyseal primordium || otic vesicle || neuroectoderm || tail fin || mesoderm || optic field
LDH N-terminal domain-like	0.3965	INHERITED FROM: bone tissue || skeletal tissue || connective tissue
Lactate & malate dehydrogenases, C-terminal domain	0.3965	INHERITED FROM: bone tissue || skeletal tissue || connective tissue
Linker histone H1/H5	0.3965	INHERITED FROM: bone tissue || skeletal tissue || connective tissue
Matrix metalloproteases, catalytic domain	0.4718	INHERITED FROM: notochord || mesodermal cell || fibroblast
G proteins	0.5311	INHERITED FROM: olfactory epithelium || olfactory sensory neuron
Sema domain	0.5376	INHERITED FROM: neural plate || midbrain-hindbrain boundary || cranial placode || involuted dorsal mesoderm || cranial neural crest || otic placode || neuroectoderm || neural crest
Link domain	0.546	INHERITED FROM: presomitic mesoderm
Tropomyosin	0.5629	INHERITED FROM: myotome || dermomyotome || myocyte || myocardium
Fibronectin type II module	0.6295	INHERITED FROM: epithelium || mesenchyme
Globins	0.6365	INHERITED FROM: anterior ventral blood island || anterior dorsal lateral plate region || ventral blood island
Intermediate filament protein, coiled coil region	0.6437	INHERITED FROM: nerve || ganglion || vestibulocochlear nerve || retinal ganglion cell || cranial nerve || retinal inner nuclear layer || retinal inner plexiform layer || optic nerve || epidermis || retinal ganglion cell layer || spinal ganglion
Kringle modules	0.6664	INHERITED FROM: neural groove
Multidrug efflux transporter AcrB transmembrane domain	0.7197	INHERITED FROM: epidermis
Arginine methyltransferase	0.7197	INHERITED FROM: cranial neural crest
Hypoxia-inducible factor Hif2a, C-terminal domain	0.8219	INHERITED FROM: pronephric tubule || epaxial muscle || otic vesicle
Integrin domains	0.8365	INHERITED FROM: mesodermal cell || fibroblast
Ephrin receptor ligand binding domain	0.8494	INHERITED FROM: branchial crest
28-residue LRR	0.8776	INHERITED FROM: epaxial muscle
Proprotein convertase P-domain	0.9177	INHERITED FROM: notochord
Motor proteins	0.9718	INHERITED FROM: musculature of face
Protein kinases, catalytic subunit	0.9952	INHERITED FROM: head mesoderm || regenerating hindlimb
TSP-1 type 1 repeat	1	INHERITED FROM: hypochord
Voltage-gated potassium channels	1	INHERITED FROM: retinal inner plexiform layer || optic nerve
Plexin repeat	1	INHERITED FROM: cranial placode || cranial neural crest || otic placode || neuroectoderm || neural crest
Calmodulin-like	1	INHERITED FROM: epithelial cell || ciliated epidermal cell
Tetramerization domain of potassium channels	1	INHERITED FROM: retinal ganglion cell || retinal inner plexiform layer || optic nerve || retinal outer plexiform layer || retinal ganglion cell layer
Fibronectin type III	1	INHERITED FROM: retinal inner nuclear layer || retinal ganglion cell layer
Rhodopsin-like	1	INHERITED FROM: granule cell layer of the olfactory bulb || eye photoreceptor cell
Classic zinc finger, C2H2	1	INHERITED FROM: chordal neural plate border || neural fold || anterior neural fold || pre-chordal neural plate || anterior neural ridge || chordal neural plate || pre-chordal neural plate border || neural plate border || splanchnic layer of lateral plate mesoderm